Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. You, H., Zeng, X., Xu, Y., Lim, C. J., Efremov, A. K, Phan, A. T., & Yan, J. Nucleic acids research, July, 2014. ![Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex As critical DNA structures capping the human chromosome ends, the stability and structural polymorphism of human telomeric G-quadruplex (G4) have drawn increasing attention in recent years. This work characterizes the equilibrium transitions of single-molecule telomeric G4 at physiological K(+) concentration. We report three folded states of telomeric G4 with markedly different lifetime and mechanical stability. Our results show that the kinetically favored folding pathway is through a short-lived intermediate state to a longer-lived state. By examining the force dependence of transition rates, the force-dependent transition free energy landscape for this pathway is determined. In addition, an ultra-long-lived form of telomeric G4 structure with a much stronger mechanical stability is identified.
@article{You2014,
title = {Dynamics and stability of polymorphic human telomeric {G}-quadruplex under tension.},
issn = {1362-4962},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25013179},
doi = {10.1093/nar/gku581},
abstract = {As critical DNA structures capping the human chromosome ends, the stability and structural polymorphism of human telomeric G-quadruplex (G4) have drawn increasing attention in recent years. This work characterizes the equilibrium transitions of single-molecule telomeric G4 at physiological K(+) concentration. We report three folded states of telomeric G4 with markedly different lifetime and mechanical stability. Our results show that the kinetically favored folding pathway is through a short-lived intermediate state to a longer-lived state. By examining the force dependence of transition rates, the force-dependent transition free energy landscape for this pathway is determined. In addition, an ultra-long-lived form of telomeric G4 structure with a much stronger mechanical stability is identified.},
number = {Cd},
journal = {Nucleic acids research},
author = {You, Huijuan and Zeng, Xiangjun and Xu, Yue and Lim, Ci Ji and Efremov, Artem K and Phan, Anh Tuân and Yan, Jie},
month = jul,
year = {2014},
pmid = {25013179},
keywords = {\#nosource},
pages = {1--7},
}
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