@ARTICLE{Young-Pearse2006-oj,
  title    = "Characterization of mice with targeted deletion of glycine
              receptor alpha 2",
  author   = "Young-Pearse, T L and Ivic, L and Kriegstein, A R and Cepko, C L",
  abstract = "Glycine receptors are ligand-gated chloride channels that mediate
              inhibitory neurotransmission in the adult nervous system. During
              development, glycine receptor alpha 2 (GlyRalpha2) is expressed
              in the retina, in the spinal cord, and throughout the brain.
              Within the cortex, GlyRalpha2 is expressed in immature cells and
              these receptors have been shown to be active and excitatory. In
              the developing retina, inhibition of glycine receptor activity
              prevents proper rod photoreceptor development. These data suggest
              that GlyRalpha2, the developmentally expressed glycine receptor,
              may play an important role in neuronal development. We have
              generated mice with a targeted deletion of glycine receptor alpha
              2 (Glra2). Although these mice lack expression of GlyRalpha2, no
              gross morphological or molecular alterations were observed in the
              nervous system. In addition, the cerebral cortex does not appear
              to require glycine receptor activity for proper development, as
              Glra2 knockout mice did not show any electrophysiological
              responses to glycine.",
  journal  = "Mol Cell Biol",
  volume   =  26,
  number   =  15,
  pages    = "5728--5734",
  month    =  aug,
  year     =  2006,
  language = "en"
}

{"_id":"Kje6sr8hv5Sjw8GWJ","bibbaseid":"youngpearse-ivic-kriegstein-cepko-characterizationofmicewithtargeteddeletionofglycinereceptoralpha2-2006","author_short":["Young-Pearse, T L","Ivic, L","Kriegstein, A R","Cepko, C L"],"bibdata":{"bibtype":"article","type":"article","title":"Characterization of mice with targeted deletion of glycine receptor alpha 2","author":[{"propositions":[],"lastnames":["Young-Pearse"],"firstnames":["T","L"],"suffixes":[]},{"propositions":[],"lastnames":["Ivic"],"firstnames":["L"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]},{"propositions":[],"lastnames":["Cepko"],"firstnames":["C","L"],"suffixes":[]}],"abstract":"Glycine receptors are ligand-gated chloride channels that mediate inhibitory neurotransmission in the adult nervous system. During development, glycine receptor alpha 2 (GlyRalpha2) is expressed in the retina, in the spinal cord, and throughout the brain. Within the cortex, GlyRalpha2 is expressed in immature cells and these receptors have been shown to be active and excitatory. In the developing retina, inhibition of glycine receptor activity prevents proper rod photoreceptor development. These data suggest that GlyRalpha2, the developmentally expressed glycine receptor, may play an important role in neuronal development. We have generated mice with a targeted deletion of glycine receptor alpha 2 (Glra2). Although these mice lack expression of GlyRalpha2, no gross morphological or molecular alterations were observed in the nervous system. In addition, the cerebral cortex does not appear to require glycine receptor activity for proper development, as Glra2 knockout mice did not show any electrophysiological responses to glycine.","journal":"Mol Cell Biol","volume":"26","number":"15","pages":"5728–5734","month":"August","year":"2006","language":"en","bibtex":"@ARTICLE{Young-Pearse2006-oj,\n title = \"Characterization of mice with targeted deletion of glycine\n receptor alpha 2\",\n author = \"Young-Pearse, T L and Ivic, L and Kriegstein, A R and Cepko, C L\",\n abstract = \"Glycine receptors are ligand-gated chloride channels that mediate\n inhibitory neurotransmission in the adult nervous system. During\n development, glycine receptor alpha 2 (GlyRalpha2) is expressed\n in the retina, in the spinal cord, and throughout the brain.\n Within the cortex, GlyRalpha2 is expressed in immature cells and\n these receptors have been shown to be active and excitatory. In\n the developing retina, inhibition of glycine receptor activity\n prevents proper rod photoreceptor development. These data suggest\n that GlyRalpha2, the developmentally expressed glycine receptor,\n may play an important role in neuronal development. We have\n generated mice with a targeted deletion of glycine receptor alpha\n 2 (Glra2). Although these mice lack expression of GlyRalpha2, no\n gross morphological or molecular alterations were observed in the\n nervous system. In addition, the cerebral cortex does not appear\n to require glycine receptor activity for proper development, as\n Glra2 knockout mice did not show any electrophysiological\n responses to glycine.\",\n journal = \"Mol Cell Biol\",\n volume = 26,\n number = 15,\n pages = \"5728--5734\",\n month = aug,\n year = 2006,\n language = \"en\"\n}\n\n","author_short":["Young-Pearse, T L","Ivic, L","Kriegstein, A R","Cepko, C L"],"key":"Young-Pearse2006-oj","id":"Young-Pearse2006-oj","bibbaseid":"youngpearse-ivic-kriegstein-cepko-characterizationofmicewithtargeteddeletionofglycinereceptoralpha2-2006","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["characterization","mice","targeted","deletion","glycine","receptor","alpha","young-pearse","ivic","kriegstein","cepko"],"title":"Characterization of mice with targeted deletion of glycine receptor alpha 2","year":2006}