@Article{yu2014,
   Author="Yu, X.  and Chen, M.  and Jiang, Z.  and Hu, Y.  and Xie, Z. ",
   Title="{{T}he two-component regulators {G}ac{S} and {G}ac{A} positively regulate a nonfluorescent siderophore through the {G}ac/{R}sm signaling cascade in high-siderophore-yielding {P}seudomonas sp. strain {H}{Y}{S}}",
   Journal="J Bacteriol",
   Year="2014",
   Volume="196",
   Number="18",
   Pages="3259--3270",
   Month="9",
   Abstract={Siderophores, which are produced to overcome iron deficiency, are believed to be closely related to the adaptability of bacteria. The high-siderophore-yielding Pseudomonas sp. strain HYS simultaneously secretes the fluorescent siderophore pyoverdine and another nonfluorescent siderophore that is a major contributor to the high siderophore yield. Transposon mutagenesis revealed siderophore-related genes, including the two-component regulators GacS/GacA and a special cluster containing four open reading frames (the nfs cluster). Deletion mutations of these genes abolished nonfluorescent-siderophore production, and expression of the nfs cluster depended on gacA, indicating that gacS-gacA may control the nonfluorescent siderophore through regulation of the nfs cluster. Furthermore, regulation of the nonfluorescent siderophore by GacS/GacA involved the Gac/Rsm pathway. In contrast, inactivation of GacS/GacA led to upregulation of the fluorescent pyoverdine. The two siderophores were secreted under different iron conditions, probably because of differential effects of GacS/GacA. The global GacS/GacA regulatory system may control iron uptake by modulating siderophore production and may enable bacteria to adapt to changing iron environments.},
   Note={[PubMed Central:\href{https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135692}{PMC4135692}] [DOI:\href{https://dx.doi.org/10.1128/JB.01756-14}{10.1128/JB.01756-14}] [PubMed:\href{https://www.ncbi.nlm.nih.gov/pubmed/18173371}{18173371}] }
}

{"_id":"xnsQuxtvZ724jWbo4","bibbaseid":"yu-chen-jiang-hu-xie-thetwocomponentregulatorsgacsandgacapositivelyregulateanonfluorescentsiderophorethroughthegacrsmsignalingcascadeinhighsiderophoreyieldingpseudomonasspstrainhys-2014","author_short":["Yu, X.","Chen, M.","Jiang, Z.","Hu, Y.","Xie, Z."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Yu"],"firstnames":["X."],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Jiang"],"firstnames":["Z."],"suffixes":[]},{"propositions":[],"lastnames":["Hu"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Xie"],"firstnames":["Z."],"suffixes":[]}],"title":"The two-component regulators GacS and GacA positively regulate a nonfluorescent siderophore through the Gac/Rsm signaling cascade in high-siderophore-yielding Pseudomonas sp. strain HYS","journal":"J Bacteriol","year":"2014","volume":"196","number":"18","pages":"3259–3270","month":"9","abstract":"Siderophores, which are produced to overcome iron deficiency, are believed to be closely related to the adaptability of bacteria. The high-siderophore-yielding Pseudomonas sp. strain HYS simultaneously secretes the fluorescent siderophore pyoverdine and another nonfluorescent siderophore that is a major contributor to the high siderophore yield. Transposon mutagenesis revealed siderophore-related genes, including the two-component regulators GacS/GacA and a special cluster containing four open reading frames (the nfs cluster). Deletion mutations of these genes abolished nonfluorescent-siderophore production, and expression of the nfs cluster depended on gacA, indicating that gacS-gacA may control the nonfluorescent siderophore through regulation of the nfs cluster. Furthermore, regulation of the nonfluorescent siderophore by GacS/GacA involved the Gac/Rsm pathway. In contrast, inactivation of GacS/GacA led to upregulation of the fluorescent pyoverdine. The two siderophores were secreted under different iron conditions, probably because of differential effects of GacS/GacA. The global GacS/GacA regulatory system may control iron uptake by modulating siderophore production and may enable bacteria to adapt to changing iron environments.","note":"[PubMed Central:\\hrefhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135692PMC4135692] [DOI:\\hrefhttps://dx.doi.org/10.1128/JB.01756-1410.1128/JB.01756-14] [PubMed:\\hrefhttps://www.ncbi.nlm.nih.gov/pubmed/1817337118173371] ","bibtex":"@Article{yu2014,\n Author=\"Yu, X. and Chen, M. and Jiang, Z. and Hu, Y. and Xie, Z. \",\n Title=\"{{T}he two-component regulators {G}ac{S} and {G}ac{A} positively regulate a nonfluorescent siderophore through the {G}ac/{R}sm signaling cascade in high-siderophore-yielding {P}seudomonas sp. strain {H}{Y}{S}}\",\n Journal=\"J Bacteriol\",\n Year=\"2014\",\n Volume=\"196\",\n Number=\"18\",\n Pages=\"3259--3270\",\n Month=\"9\",\n Abstract={Siderophores, which are produced to overcome iron deficiency, are believed to be closely related to the adaptability of bacteria. The high-siderophore-yielding Pseudomonas sp. strain HYS simultaneously secretes the fluorescent siderophore pyoverdine and another nonfluorescent siderophore that is a major contributor to the high siderophore yield. Transposon mutagenesis revealed siderophore-related genes, including the two-component regulators GacS/GacA and a special cluster containing four open reading frames (the nfs cluster). Deletion mutations of these genes abolished nonfluorescent-siderophore production, and expression of the nfs cluster depended on gacA, indicating that gacS-gacA may control the nonfluorescent siderophore through regulation of the nfs cluster. Furthermore, regulation of the nonfluorescent siderophore by GacS/GacA involved the Gac/Rsm pathway. In contrast, inactivation of GacS/GacA led to upregulation of the fluorescent pyoverdine. The two siderophores were secreted under different iron conditions, probably because of differential effects of GacS/GacA. The global GacS/GacA regulatory system may control iron uptake by modulating siderophore production and may enable bacteria to adapt to changing iron environments.},\n Note={[PubMed Central:\\href{https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135692}{PMC4135692}] [DOI:\\href{https://dx.doi.org/10.1128/JB.01756-14}{10.1128/JB.01756-14}] [PubMed:\\href{https://www.ncbi.nlm.nih.gov/pubmed/18173371}{18173371}] }\n}\n\n","author_short":["Yu, X.","Chen, M.","Jiang, Z.","Hu, Y.","Xie, Z."],"key":"yu2014","id":"yu2014","bibbaseid":"yu-chen-jiang-hu-xie-thetwocomponentregulatorsgacsandgacapositivelyregulateanonfluorescentsiderophorethroughthegacrsmsignalingcascadeinhighsiderophoreyieldingpseudomonasspstrainhys-2014","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/network/files/7omCQCMxvjPCQZfjb","dataSources":["4EGaEr5EKz54T8jGa"],"keywords":[],"search_terms":["two","component","regulators","gacs","gaca","positively","regulate","nonfluorescent","siderophore","through","gac","rsm","signaling","cascade","high","siderophore","yielding","pseudomonas","strain","hys","yu","chen","jiang","hu","xie"],"title":"The two-component regulators GacS and GacA positively regulate a nonfluorescent siderophore through the Gac/Rsm signaling cascade in high-siderophore-yielding Pseudomonas sp. strain HYS","year":2014}