Subretinal fluid is common in experimental non-arteritic anterior ischemic optic neuropathy. Yu, C., Ho, J. K., & Liao, Y. J. Eye (London, England), 28(12):1494--1501, December, 2014. 00003
doi  abstract   bibtex   
PURPOSE: Anterior ischemic optic neuropathy (AION) is an important cause of acute vision loss for which several animal models exist. It has been associated with subretinal fluid in a previous study on patients but not yet so in animal models. PATIENTS AND METHODS: A patient presented with acute non-arteritic AION (NAION) and underwent ophthalmic evaluation and testing including fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT). On the basis of the patient's findings, we used SD-OCT circular and volume scans to analyze retinal changes in a murine model of NAION. RESULTS: One week after left eye vision loss, the patient had clinical and imaging findings consistent with NAION. On SD-OCT, there was prominent peripapillary retinal thickening consistent with intra-retinal edema and sub-foveolar fluid. Inspired by the findings in human AION, we looked for similar changes in murine NAION using SD-OCT. The circular scan did not adequately detect the presence of subretinal fluid. Using the 25-line scan, which covered a larger part of the posterior pole, we found that 100% of murine AION resulted in subretinal fluid at day 1. The subretinal fluid resolved by week 1. CONCLUSION: This study detailed a case of clinical NAION associated with intra-retinal and subretinal fluid. We also found that subretinal fluid was common in murine photochemical thrombosis model of AION and could be found far away from the optic disc.
@article{yu_subretinal_2014,
	title = {Subretinal fluid is common in experimental non-arteritic anterior ischemic optic neuropathy},
	volume = {28},
	issn = {1476-5454},
	doi = {10.1038/eye.2014.220},
	abstract = {PURPOSE: Anterior ischemic optic neuropathy (AION) is an important cause of acute vision loss for which several animal models exist. It has been associated with subretinal fluid in a previous study on patients but not yet so in animal models.
PATIENTS AND METHODS: A patient presented with acute non-arteritic AION (NAION) and underwent ophthalmic evaluation and testing including fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT). On the basis of the patient's findings, we used SD-OCT circular and volume scans to analyze retinal changes in a murine model of NAION.
RESULTS: One week after left eye vision loss, the patient had clinical and imaging findings consistent with NAION. On SD-OCT, there was prominent peripapillary retinal thickening consistent with intra-retinal edema and sub-foveolar fluid. Inspired by the findings in human AION, we looked for similar changes in murine NAION using SD-OCT. The circular scan did not adequately detect the presence of subretinal fluid. Using the 25-line scan, which covered a larger part of the posterior pole, we found that 100\% of murine AION resulted in subretinal fluid at day 1. The subretinal fluid resolved by week 1.
CONCLUSION: This study detailed a case of clinical NAION associated with intra-retinal and subretinal fluid. We also found that subretinal fluid was common in murine photochemical thrombosis model of AION and could be found far away from the optic disc.},
	language = {eng},
	number = {12},
	journal = {Eye (London, England)},
	author = {Yu, C. and Ho, J. K. and Liao, Y. J.},
	month = dec,
	year = {2014},
	pmid = {25257770},
	pmcid = {PMC4268460},
	note = {00003 },
	keywords = {Aged, Animals, Arteritis, Disease Models, Animal, Fluorescein Angiography, Humans, Lasers, Solid-State, Male, Mice, Mice, Inbred BALB C, Optic Disk, Optic Neuropathy, Ischemic, Papilledema, Rose Bengal, Subretinal Fluid, Thrombosis, Tomography, Optical Coherence, Vision Disorders, Visual Acuity, Visual Fields},
	pages = {1494--1501}
}

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