@article{
 title = {Cannabis-Associated Psychotic-Like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus},
 type = {article},
 year = {2019},
 identifiers = {[object Object]},
 websites = {https://www.sciencedirect.com/science/article/abs/pii/S0890856719304691},
 month = {7},
 publisher = {Elsevier},
 day = {18},
 id = {d4be9cf9-51f3-343c-a06e-33dc683c5a6a},
 created = {2019-07-27T17:03:19.942Z},
 accessed = {2019-07-24},
 file_attached = {false},
 profile_id = {078d13e5-632a-3ebf-9e0e-51a0b2c2c66e},
 group_id = {d9389c6c-8ab5-3b8b-86ed-33db09ca0198},
 last_modified = {2019-07-27T17:03:19.942Z},
 tags = {CA,Disc:Psychopharmacology},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 notes = {LB},
 private_publication = {false},
 abstract = {OBJECTIVE
Cannabis consumption during adolescence has been reported as a risk-factor for psychotic-like experiences (PLEs) and schizophrenia. However, brain developmental processes associated with cannabis-related PLEs are still ill-described. 

METHOD
706 adolescents from the general population that were recruited by the IMAGEN consortium had structural MRI scans both at 14 and 19 years-old. We used deformation-based morphometry to map voxel-wise brain changes between the two time points, using the pairwise algorithm in SPM12b. We used an a-priori region of interest (ROI) approach focusing on the hippocampus/parahippocampus to perform voxel-wise linear regressions. Life time cannabis consumption was assessed using the European School Survey Project on Alcohol and other Drugs (ESPAD) and PLEs were assessed with the Comprehensive Assessment Psychotic-like experiences (CAPE). We first tested whether hippocampus/para-hippocampus development was associated with PLEs. Then, we formulated and tested an a-priori simple mediation model where uncus development mediates the association between lifetime cannabis consumption and PLEs. 

RESULTS
We found that PLEs was associated with reduced expansion within a specific region of the right hippocampus/para-hippocampus formation, the uncus (p=0.002 at the cluster level, p=0.018 at the peak-level). The partial simple mediation model revealed a significant total effect from lifetime cannabis consumption to PLEs (b=0.069 95CI [0.04-0.1], p=2 x 10-16), as well as a small yet significant, indirect effect of right uncus development (0.004, 95IC [0.0004-0.01], p=0.026). 

CONCLUSION
We show here that the uncus development is involved in the cerebral basis of PLEs in a population-based sample of healthy adolescents.},
 bibtype = {article},
 author = {Yu, Tao and Jia, Tianye and Zhu, Liping and Desrivières, Sylvane and Macare, Christine and Bi, Yan and Bokde, Arun L.W. and Quinlan, Erin Burke and Heinz, Andreas and Ittermann, Bernd and Liu, ChuanXin and Ji, Lei and Banaschewski, Tobias and Ren, Decheng and Du, Li and Hou, Binyin and Flor, Herta and Frouin, Vincent and Garavan, Hugh and Gowland, Penny and Martinot, Jean-Luc and Paillère Martinot, Marie-Laure and Nees, Frauke and Orfanos, Dimitri Papadopoulos and Luo, Qiang and Chu, Congying and Paus, Tomas and Poustka, Luise and Hohmann, Sarah and Millenet, Sabina and Smolka, Michael N. and Vetter, Nora C. and Mennigen, Eva and Lei, Cai and Walter, Henrik and Fröhner, Juliane H. and Whelan, Robert and He, Guang and He, Lin and Schumann, Gunter and Robert, Gabriel},
 journal = {Journal of the American Academy of Child & Adolescent Psychiatry}
}

{"_id":"cM9FzZn4EbTb8TsX6","bibbaseid":"yu-jia-zhu-desrivires-macare-bi-bokde-quinlan-etal-cannabisassociatedpsychoticlikeexperiencesaremediatedbydevelopmentalchangesintheparahippocampalgyrus-2019","authorIDs":[],"author_short":["Yu, T.","Jia, T.","Zhu, L.","Desrivières, S.","Macare, C.","Bi, Y.","Bokde, A., L.","Quinlan, E., B.","Heinz, A.","Ittermann, B.","Liu, C.","Ji, L.","Banaschewski, T.","Ren, D.","Du, L.","Hou, B.","Flor, H.","Frouin, V.","Garavan, H.","Gowland, P.","Martinot, J.","Paillère Martinot, M.","Nees, F.","Orfanos, D., P.","Luo, Q.","Chu, C.","Paus, T.","Poustka, L.","Hohmann, S.","Millenet, S.","Smolka, M., N.","Vetter, N., C.","Mennigen, E.","Lei, C.","Walter, H.","Fröhner, J., H.","Whelan, R.","He, G.","He, L.","Schumann, G.","Robert, G."],"bibdata":{"title":"Cannabis-Associated Psychotic-Like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus","type":"article","year":"2019","identifiers":"[object Object]","websites":"https://www.sciencedirect.com/science/article/abs/pii/S0890856719304691","month":"7","publisher":"Elsevier","day":"18","id":"d4be9cf9-51f3-343c-a06e-33dc683c5a6a","created":"2019-07-27T17:03:19.942Z","accessed":"2019-07-24","file_attached":false,"profile_id":"078d13e5-632a-3ebf-9e0e-51a0b2c2c66e","group_id":"d9389c6c-8ab5-3b8b-86ed-33db09ca0198","last_modified":"2019-07-27T17:03:19.942Z","tags":"CA,Disc:Psychopharmacology","read":false,"starred":false,"authored":false,"confirmed":false,"hidden":false,"notes":"LB","private_publication":false,"abstract":"OBJECTIVE\r\nCannabis consumption during adolescence has been reported as a risk-factor for psychotic-like experiences (PLEs) and schizophrenia. However, brain developmental processes associated with cannabis-related PLEs are still ill-described. \r\n\r\nMETHOD\r\n706 adolescents from the general population that were recruited by the IMAGEN consortium had structural MRI scans both at 14 and 19 years-old. We used deformation-based morphometry to map voxel-wise brain changes between the two time points, using the pairwise algorithm in SPM12b. We used an a-priori region of interest (ROI) approach focusing on the hippocampus/parahippocampus to perform voxel-wise linear regressions. Life time cannabis consumption was assessed using the European School Survey Project on Alcohol and other Drugs (ESPAD) and PLEs were assessed with the Comprehensive Assessment Psychotic-like experiences (CAPE). We first tested whether hippocampus/para-hippocampus development was associated with PLEs. Then, we formulated and tested an a-priori simple mediation model where uncus development mediates the association between lifetime cannabis consumption and PLEs. \r\n\r\nRESULTS\r\nWe found that PLEs was associated with reduced expansion within a specific region of the right hippocampus/para-hippocampus formation, the uncus (p=0.002 at the cluster level, p=0.018 at the peak-level). The partial simple mediation model revealed a significant total effect from lifetime cannabis consumption to PLEs (b=0.069 95CI [0.04-0.1], p=2 x 10-16), as well as a small yet significant, indirect effect of right uncus development (0.004, 95IC [0.0004-0.01], p=0.026). \r\n\r\nCONCLUSION\r\nWe show here that the uncus development is involved in the cerebral basis of PLEs in a population-based sample of healthy adolescents.","bibtype":"article","author":"Yu, Tao and Jia, Tianye and Zhu, Liping and Desrivières, Sylvane and Macare, Christine and Bi, Yan and Bokde, Arun L.W. and Quinlan, Erin Burke and Heinz, Andreas and Ittermann, Bernd and Liu, ChuanXin and Ji, Lei and Banaschewski, Tobias and Ren, Decheng and Du, Li and Hou, Binyin and Flor, Herta and Frouin, Vincent and Garavan, Hugh and Gowland, Penny and Martinot, Jean-Luc and Paillère Martinot, Marie-Laure and Nees, Frauke and Orfanos, Dimitri Papadopoulos and Luo, Qiang and Chu, Congying and Paus, Tomas and Poustka, Luise and Hohmann, Sarah and Millenet, Sabina and Smolka, Michael N. and Vetter, Nora C. and Mennigen, Eva and Lei, Cai and Walter, Henrik and Fröhner, Juliane H. and Whelan, Robert and He, Guang and He, Lin and Schumann, Gunter and Robert, Gabriel","journal":"Journal of the American Academy of Child & Adolescent Psychiatry","bibtex":"@article{\n title = {Cannabis-Associated Psychotic-Like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus},\n type = {article},\n year = {2019},\n identifiers = {[object Object]},\n websites = {https://www.sciencedirect.com/science/article/abs/pii/S0890856719304691},\n month = {7},\n publisher = {Elsevier},\n day = {18},\n id = {d4be9cf9-51f3-343c-a06e-33dc683c5a6a},\n created = {2019-07-27T17:03:19.942Z},\n accessed = {2019-07-24},\n file_attached = {false},\n profile_id = {078d13e5-632a-3ebf-9e0e-51a0b2c2c66e},\n group_id = {d9389c6c-8ab5-3b8b-86ed-33db09ca0198},\n last_modified = {2019-07-27T17:03:19.942Z},\n tags = {CA,Disc:Psychopharmacology},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {false},\n hidden = {false},\n notes = {LB},\n private_publication = {false},\n abstract = {OBJECTIVE\r\nCannabis consumption during adolescence has been reported as a risk-factor for psychotic-like experiences (PLEs) and schizophrenia. However, brain developmental processes associated with cannabis-related PLEs are still ill-described. \r\n\r\nMETHOD\r\n706 adolescents from the general population that were recruited by the IMAGEN consortium had structural MRI scans both at 14 and 19 years-old. We used deformation-based morphometry to map voxel-wise brain changes between the two time points, using the pairwise algorithm in SPM12b. We used an a-priori region of interest (ROI) approach focusing on the hippocampus/parahippocampus to perform voxel-wise linear regressions. Life time cannabis consumption was assessed using the European School Survey Project on Alcohol and other Drugs (ESPAD) and PLEs were assessed with the Comprehensive Assessment Psychotic-like experiences (CAPE). We first tested whether hippocampus/para-hippocampus development was associated with PLEs. Then, we formulated and tested an a-priori simple mediation model where uncus development mediates the association between lifetime cannabis consumption and PLEs. \r\n\r\nRESULTS\r\nWe found that PLEs was associated with reduced expansion within a specific region of the right hippocampus/para-hippocampus formation, the uncus (p=0.002 at the cluster level, p=0.018 at the peak-level). The partial simple mediation model revealed a significant total effect from lifetime cannabis consumption to PLEs (b=0.069 95CI [0.04-0.1], p=2 x 10-16), as well as a small yet significant, indirect effect of right uncus development (0.004, 95IC [0.0004-0.01], p=0.026). \r\n\r\nCONCLUSION\r\nWe show here that the uncus development is involved in the cerebral basis of PLEs in a population-based sample of healthy adolescents.},\n bibtype = {article},\n author = {Yu, Tao and Jia, Tianye and Zhu, Liping and Desrivières, Sylvane and Macare, Christine and Bi, Yan and Bokde, Arun L.W. and Quinlan, Erin Burke and Heinz, Andreas and Ittermann, Bernd and Liu, ChuanXin and Ji, Lei and Banaschewski, Tobias and Ren, Decheng and Du, Li and Hou, Binyin and Flor, Herta and Frouin, Vincent and Garavan, Hugh and Gowland, Penny and Martinot, Jean-Luc and Paillère Martinot, Marie-Laure and Nees, Frauke and Orfanos, Dimitri Papadopoulos and Luo, Qiang and Chu, Congying and Paus, Tomas and Poustka, Luise and Hohmann, Sarah and Millenet, Sabina and Smolka, Michael N. and Vetter, Nora C. and Mennigen, Eva and Lei, Cai and Walter, Henrik and Fröhner, Juliane H. and Whelan, Robert and He, Guang and He, Lin and Schumann, Gunter and Robert, Gabriel},\n journal = {Journal of the American Academy of Child & Adolescent Psychiatry}\n}","author_short":["Yu, T.","Jia, T.","Zhu, L.","Desrivières, S.","Macare, C.","Bi, Y.","Bokde, A., L.","Quinlan, E., B.","Heinz, A.","Ittermann, B.","Liu, C.","Ji, L.","Banaschewski, T.","Ren, D.","Du, L.","Hou, B.","Flor, H.","Frouin, V.","Garavan, H.","Gowland, P.","Martinot, J.","Paillère Martinot, M.","Nees, F.","Orfanos, D., P.","Luo, Q.","Chu, C.","Paus, T.","Poustka, L.","Hohmann, S.","Millenet, S.","Smolka, M., N.","Vetter, N., C.","Mennigen, E.","Lei, C.","Walter, H.","Fröhner, J., H.","Whelan, R.","He, G.","He, L.","Schumann, G.","Robert, G."],"urls":{"Website":"https://www.sciencedirect.com/science/article/abs/pii/S0890856719304691"},"bibbaseid":"yu-jia-zhu-desrivires-macare-bi-bokde-quinlan-etal-cannabisassociatedpsychoticlikeexperiencesaremediatedbydevelopmentalchangesintheparahippocampalgyrus-2019","role":"author","downloads":0},"bibtype":"article","creationDate":"2019-07-28T12:55:41.095Z","downloads":0,"keywords":[],"search_terms":["cannabis","associated","psychotic","experiences","mediated","developmental","changes","parahippocampal","gyrus","yu","jia","zhu","desrivières","macare","bi","bokde","quinlan","heinz","ittermann","liu","ji","banaschewski","ren","du","hou","flor","frouin","garavan","gowland","martinot","paillère martinot","nees","orfanos","luo","chu","paus","poustka","hohmann","millenet","smolka","vetter","mennigen","lei","walter","fröhner","whelan","he","he","schumann","robert"],"title":"Cannabis-Associated Psychotic-Like Experiences Are Mediated by Developmental Changes in the Parahippocampal Gyrus","year":2019}