High-contrast Noninvasive Imaging of Kidney Clearance Kinetics Enabled by Renal Clearable Nanofluorophores. Yu, M., Liu, J., Ning, X., & Zheng, J. Angewandte Chemie (International ed. in English), 54(51):15434–15438, December, 2015. ![High-contrast Noninvasive Imaging of Kidney Clearance Kinetics Enabled by Renal Clearable Nanofluorophores [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Noninvasive imaging of kidney clearance kinetics (KCK) of renal clearable probes is key to studying unilateral kidney functional diseases but is highly challenging to be achieved with in vivo fluorescence imaging. While this long-standing challenge is often attributed to the limited light penetration depth, we found that rapid and persistent accumulation of conventional dyes in the skin “shadowed” real fluorescence signals from the kidneys and prevented noninvasive imaging of KCK, which, however, can be addressed with renal clearable nanofluorophores. By integrating near infrared emission with efficient renal clearance and ultralow background interference, the nanofluorophores can increase kidney-contrast enhancement and imaging-time window by ~50 and ~1000 times over conventional dyes and significantly minimize deviation between noninvasive and invasive KCK, laying down a foundation for translating in vivo fluorescence imaging in preclinical noninvasive kidney function assessment.
@article{yu_high-contrast_2015,
title = {High-contrast {Noninvasive} {Imaging} of {Kidney} {Clearance} {Kinetics} {Enabled} by {Renal} {Clearable} {Nanofluorophores}},
volume = {54},
issn = {1433-7851},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715620/},
doi = {10.1002/anie.201507868},
abstract = {Noninvasive imaging of kidney clearance kinetics (KCK) of renal clearable probes is key to studying unilateral kidney functional diseases but is highly challenging to be achieved with in vivo fluorescence imaging. While this long-standing challenge is often attributed to the limited light penetration depth, we found that rapid and persistent accumulation of conventional dyes in the skin “shadowed” real fluorescence signals from the kidneys and prevented noninvasive imaging of KCK, which, however, can be addressed with renal clearable nanofluorophores. By integrating near infrared emission with efficient renal clearance and ultralow background interference, the nanofluorophores can increase kidney-contrast enhancement and imaging-time window by {\textasciitilde}50 and {\textasciitilde}1000 times over conventional dyes and significantly minimize deviation between noninvasive and invasive KCK, laying down a foundation for translating in vivo fluorescence imaging in preclinical noninvasive kidney function assessment.},
number = {51},
urldate = {2024-03-06},
journal = {Angewandte Chemie (International ed. in English)},
author = {Yu, Mengxiao and Liu, Jinbin and Ning, Xuhui and Zheng, Jie},
month = dec,
year = {2015},
pmid = {26510715},
pmcid = {PMC4715620},
pages = {15434--15438},
}
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