Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA. Yu, H., Wang, X., Fu, M., Ren, J., & Qu, X. Nucleic acids research, 36(17):5695–703, October, 2008. ![Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Here, we report the first example that one enantiomer of a supramolecular cylinder can selectively stabilize human telomeric G-quadruplex DNA. The P-enantiomer of this cylinder has a strong preference for G-quadruplex over duplex DNA and, in the presence of sodium, can convert G-quadruplexes from an antiparallel to a hybrid structure. The compound's chiral selectivity and its ability to discriminate quadruplex DNA have been studied by DNA melting, circular dichroism, gel electrophoresis, fluorescence spectroscopy and S1 nuclease cleavage. The chiral supramolecular complex has both small molecular chemical features and the large size of a zinc-finger-like DNA-binding motif. The complex is also convenient to synthesize and separate enantiomers. These results provide new insights into the development of chiral anticancer agents for targeting G-quadruplex DNA.
@article{Yu2008,
title = {Chiral metallo-supramolecular complexes selectively recognize human telomeric {G}-quadruplex {DNA}.},
volume = {36},
issn = {1362-4962},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2553577&tool=pmcentrez&rendertype=abstract},
doi = {10.1093/nar/gkn569},
abstract = {Here, we report the first example that one enantiomer of a supramolecular cylinder can selectively stabilize human telomeric G-quadruplex DNA. The P-enantiomer of this cylinder has a strong preference for G-quadruplex over duplex DNA and, in the presence of sodium, can convert G-quadruplexes from an antiparallel to a hybrid structure. The compound's chiral selectivity and its ability to discriminate quadruplex DNA have been studied by DNA melting, circular dichroism, gel electrophoresis, fluorescence spectroscopy and S1 nuclease cleavage. The chiral supramolecular complex has both small molecular chemical features and the large size of a zinc-finger-like DNA-binding motif. The complex is also convenient to synthesize and separate enantiomers. These results provide new insights into the development of chiral anticancer agents for targeting G-quadruplex DNA.},
number = {17},
journal = {Nucleic acids research},
author = {Yu, Haijia and Wang, Xiaohui and Fu, Manliang and Ren, Jinsong and Qu, Xiaogang},
month = oct,
year = {2008},
pmid = {18776218},
keywords = {\#nosource, Antineoplastic Agents, Antineoplastic Agents: chemistry, DNA, DNA: chemistry, Ferrous Compounds, Ferrous Compounds: chemistry, G-Quadruplexes, Humans, Stereoisomerism, Telomere, Telomere: chemistry},
pages = {5695--703},
}
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The compound's chiral selectivity and its ability to discriminate quadruplex DNA have been studied by DNA melting, circular dichroism, gel electrophoresis, fluorescence spectroscopy and S1 nuclease cleavage. The chiral supramolecular complex has both small molecular chemical features and the large size of a zinc-finger-like DNA-binding motif. The complex is also convenient to synthesize and separate enantiomers. 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The P-enantiomer of this cylinder has a strong preference for G-quadruplex over duplex DNA and, in the presence of sodium, can convert G-quadruplexes from an antiparallel to a hybrid structure. The compound's chiral selectivity and its ability to discriminate quadruplex DNA have been studied by DNA melting, circular dichroism, gel electrophoresis, fluorescence spectroscopy and S1 nuclease cleavage. The chiral supramolecular complex has both small molecular chemical features and the large size of a zinc-finger-like DNA-binding motif. The complex is also convenient to synthesize and separate enantiomers. 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