[Impact of continuous blood purification on T cell subsets in children with severe sepsis]. Yuan, Y., Yuan, Y., Xiao, Z., Zhang, H., Fan, J., Zhang, X., Lu, X., Xu, Z., & Luo, H. Chinese journal of contemporary pediatrics, 16(2):194 – 197, February, 2014. ![[Impact of continuous blood purification on T cell subsets in children with severe sepsis]. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex OBJECTIVE:To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis. METHODS:A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment. RESULTS:The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P\textless0.05). In the CBP treatment group, the percentage of CD3(+), CD4(+), CD8(+) T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P\textless0.05). At 7 days after treatment, the percentage of CD3(+), CD4(+), CD8(+) T cell populations, CD4(+)/CD8(+) ratio and PCIS scores were significantly higher in the CBP group than in the control group (P\textless0.05). CONCLUSIONS:The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.
@article{yuan_impact_2014,
title = {[{Impact} of continuous blood purification on {T} cell subsets in children with severe sepsis].},
volume = {16},
url = {https://app.readcube.com/library/d55a0da2-06b3-4d90-8ff1-3099d227a5b8/item/6401b46f-8d34-4c4f-b295-606cf723a216},
abstract = {OBJECTIVE:To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis.
METHODS:A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment.
RESULTS:The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P{\textless}0.05). In the CBP treatment group, the percentage of CD3(+), CD4(+), CD8(+) T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P{\textless}0.05). At 7 days after treatment, the percentage of CD3(+), CD4(+), CD8(+) T cell populations, CD4(+)/CD8(+) ratio and PCIS scores were significantly higher in the CBP group than in the control group (P{\textless}0.05).
CONCLUSIONS:The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.},
language = {Chinese},
number = {2},
journal = {Chinese journal of contemporary pediatrics},
author = {Yuan, Yuan-Hong and Yuan, Yuan-Hong and Xiao, Zheng-Hui and Zhang, Hui and Fan, Jiang-Hua and Zhang, Xin-Ping and Lu, Xiu-Lan and Xu, Zhi-Yue and Luo, Hai-Yan},
month = feb,
year = {2014},
pages = {194 -- 197},
}
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METHODS:A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment. RESULTS:The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P\\textless0.05). In the CBP treatment group, the percentage of CD3(+), CD4(+), CD8(+) T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P\\textless0.05). At 7 days after treatment, the percentage of CD3(+), CD4(+), CD8(+) T cell populations, CD4(+)/CD8(+) ratio and PCIS scores were significantly higher in the CBP group than in the control group (P\\textless0.05). CONCLUSIONS:The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.","language":"Chinese","number":"2","journal":"Chinese journal of contemporary pediatrics","author":[{"propositions":[],"lastnames":["Yuan"],"firstnames":["Yuan-Hong"],"suffixes":[]},{"propositions":[],"lastnames":["Yuan"],"firstnames":["Yuan-Hong"],"suffixes":[]},{"propositions":[],"lastnames":["Xiao"],"firstnames":["Zheng-Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Fan"],"firstnames":["Jiang-Hua"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Xin-Ping"],"suffixes":[]},{"propositions":[],"lastnames":["Lu"],"firstnames":["Xiu-Lan"],"suffixes":[]},{"propositions":[],"lastnames":["Xu"],"firstnames":["Zhi-Yue"],"suffixes":[]},{"propositions":[],"lastnames":["Luo"],"firstnames":["Hai-Yan"],"suffixes":[]}],"month":"February","year":"2014","pages":"194 – 197","bibtex":"@article{yuan_impact_2014,\n\ttitle = {[{Impact} of continuous blood purification on {T} cell subsets in children with severe sepsis].},\n\tvolume = {16},\n\turl = {https://app.readcube.com/library/d55a0da2-06b3-4d90-8ff1-3099d227a5b8/item/6401b46f-8d34-4c4f-b295-606cf723a216},\n\tabstract = {OBJECTIVE:To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis.\n\nMETHODS:A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment.\n\nRESULTS:The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P{\\textless}0.05). In the CBP treatment group, the percentage of CD3(+), CD4(+), CD8(+) T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P{\\textless}0.05). At 7 days after treatment, the percentage of CD3(+), CD4(+), CD8(+) T cell populations, CD4(+)/CD8(+) ratio and PCIS scores were significantly higher in the CBP group than in the control group (P{\\textless}0.05).\n\nCONCLUSIONS:The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.},\n\tlanguage = {Chinese},\n\tnumber = {2},\n\tjournal = {Chinese journal of contemporary pediatrics},\n\tauthor = {Yuan, Yuan-Hong and Yuan, Yuan-Hong and Xiao, Zheng-Hui and Zhang, Hui and Fan, Jiang-Hua and Zhang, Xin-Ping and Lu, Xiu-Lan and Xu, Zhi-Yue and Luo, Hai-Yan},\n\tmonth = feb,\n\tyear = {2014},\n\tpages = {194 -- 197},\n}\n\n\n\n","author_short":["Yuan, Y.","Yuan, Y.","Xiao, Z.","Zhang, H.","Fan, J.","Zhang, X.","Lu, X.","Xu, Z.","Luo, H."],"key":"yuan_impact_2014","id":"yuan_impact_2014","bibbaseid":"yuan-yuan-xiao-zhang-fan-zhang-lu-xu-etal-impactofcontinuousbloodpurificationontcellsubsetsinchildrenwithseveresepsis-2014","role":"author","urls":{"Paper":"https://app.readcube.com/library/d55a0da2-06b3-4d90-8ff1-3099d227a5b8/item/6401b46f-8d34-4c4f-b295-606cf723a216"},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"search_terms":["impact","continuous","blood","purification","cell","subsets","children","severe","sepsis","yuan","yuan","xiao","zhang","fan","zhang","lu","xu","luo"],"keywords":[],"authorIDs":[],"dataSources":["4P4hKw3sZj97Zz2kx"]}