Interactions between antinociception induced by cholecystokinin antagonists and GABA agonists in the tail-flick test. Zarrindast, M. R., Rezayat, M., Ghanipoor, N., & Parvini, S. Pharmacology & toxicology, 83(4):143–148, October, 1998. PMID 9820874
doi  abstract   bibtex   
In this work, the influences of cholecystokinin receptor antagonists L-365,260, MK-329 and proglumide on antinociception induced by baclofen and GABA uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (THPO) in the tail flick test has been studied. Baclofen and THPO induced antinociception in the tail flick test. Morphine, and the CCK receptor antagonists, MK-329, L-365,260 and proglumide also induced antinociception. The CCK receptor antagonists potentiated antinociceptive response induced by both baclofen and THPO. It may be concluded that cholecystokinin receptor mechanism(s) may interact with antinociception induced by GABA receptor mechanism(s).
@article{zarrindast_interactions_1998,
	title = {Interactions between antinociception induced by cholecystokinin antagonists and {GABA} agonists in the tail-flick test.},
	volume = {83},
	issn = {0901-9928},
	doi = {10.1111/j.1600-0773.1998.tb01460.x},
	abstract = {In this work, the influences of cholecystokinin receptor antagonists L-365,260, MK-329 and proglumide on antinociception induced by baclofen and GABA uptake  inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (THPO) in the tail flick  test has been studied. Baclofen and THPO induced antinociception in the tail flick  test. Morphine, and the CCK receptor antagonists, MK-329, L-365,260 and proglumide  also induced antinociception. The CCK receptor antagonists potentiated  antinociceptive response induced by both baclofen and THPO. It may be concluded that  cholecystokinin receptor mechanism(s) may interact with antinociception induced by  GABA receptor mechanism(s).},
	language = {eng},
	number = {4},
	journal = {Pharmacology \& toxicology},
	author = {Zarrindast, M. R. and Rezayat, M. and Ghanipoor, N. and Parvini, S.},
	month = oct,
	year = {1998},
	note = {PMID 9820874},
	keywords = {Animals, Baclofen/pharmacology, Benzodiazepinones/pharmacology, Devazepide/pharmacology, Dose-Response Relationship, Drug, Drug Interactions, GABA Agonists/*pharmacology, Isoxazoles/pharmacology, Male, Mice, Motor Activity/drug effects, Pain Measurement/*drug effects, Pain/drug therapy, Phenylurea Compounds/pharmacology, Proglumide/pharmacology, Receptors, Cholecystokinin/*antagonists \& inhibitors, Tail},
	pages = {143--148},
}

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