@article{ zavascki_risk_2006,
  abstract = {{OBJECTIVES:} To assess risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase {(MBL-PA)} in two teaching hospitals where horizontal dissemination has been demonstrated. {METHODS:} A case-control study was performed in both hospitals (assigned as hospital 1 and 2). Cases were patients with {MBL-PA} infections and controls were those with {non-MBL-PA} infections. Multivariate analysis was performed to identify independent risk factors. {RESULTS:} A total of 86 cases and 212 controls were included in the study. A logistic regression model showed that exposure to beta-lactams [odds ratio {(OR)} 3.21; 95% confidence interval {(CI)} 1.74-5.93] or fluoroquinolones {(OR} 3.50; 95% {CI} 1.46-8.37) was associated with {MBL-PA} infections. Other independent risk factors were neurological disease {(OR} 3.00; 95% {CI} 1.61-5.58), urinary tract infection {(OR} 2.48; 95% {CI} 1.21-5.09) and renal failure {(OR} 2.29; 95% {CI} 1.13-4.65). Admission to hospital 1 {(OR} 5.97; 95% {CI} 3.45-14.09) and intensive care unit stay {(OR} 2.07; 95% {CI} 1.46-3.96) were also associated with increased risk for {MBL-PA} infections. {CONCLUSIONS:} {beta-Lactam} exposure is an important risk factor for {MBL-PA} infections even in a setting where patient-to-patient transmission plays a major role in the spread of the isolates. Other risk factors deserve further investigation, particularly exposure to fluoroquinolones.},
  added-at = {2011-03-11T10:05:34.000+0100},
  author = {Zavascki, Alexandre Prehn and Barth, Afonso Luís and Gaspareto, Patrick Barcelos and Gonçalves, Ana Lúcia Saraiva and Moro, Ana Lúcia Didonet and Fernandes, Juliana Fernandez and Goldani, Luciano Zubaran},
  biburl = {http://www.bibsonomy.org/bibtex/229811950b972d115db2472556dc63e19/jelias},
  doi = {10.1093/jac/dkl327},
  interhash = {d0c880050355b1532c460930b2f9f056},
  intrahash = {29811950b972d115db2472556dc63e19},
  issn = {0305-7453},
  journal = {The Journal of Antimicrobial Chemotherapy},
  keywords = {Adult, Aged, Agents, Cross Factors Female, Fluoroquinolones, Hospitals, Humans, Incidence, Infection, Infections, Male, Middle Pseudomonas Risk Studies, Teaching, aeruginosa, {Anti-Bacterial} {Case-Control} {beta-Lactamases,} {beta-Lactams,}},
  month = {October},
  note = {{PMID:} 16895936},
  number = {4},
  pages = {882--5},
  title = {Risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase in two tertiary-care teaching hospitals},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/16895936},
  volume = {58},
  year = {2006}
}

{"_id":"AufJsJwXuAGRcFzpJ","authorIDs":[],"author_short":["Zavascki","Prehn, A.","Barth","Luís, A.","Gaspareto","Barcelos, P.","Gonçalves","Saraiva, A.<nbsp>L.","Moro","Didonet, A.<nbsp>L.","Fernandes","Fernandez, J.","Goldani","Zubaran, L."],"bibbaseid":"zavascki-prehn-barth-lus-gaspareto-barcelos-gonalves-saraiva-moro-didonet-fernandes-fernandez-goldani-zubaran-riskfactorsfornosocomialinfectionsduetopseudomonasaeruginosaproducingmetallobetalactamaseintwotertiarycareteachinghospitals-2006","bibdata":{"abstract":"OBJECTIVES: To assess risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase (MBL-PA) in two teaching hospitals where horizontal dissemination has been demonstrated. METHODS: A case-control study was performed in both hospitals (assigned as hospital 1 and 2). Cases were patients with MBL-PA infections and controls were those with non-MBL-PA infections. Multivariate analysis was performed to identify independent risk factors. RESULTS: A total of 86 cases and 212 controls were included in the study. A logistic regression model showed that exposure to beta-lactams [odds ratio (OR) 3.21; 95% confidence interval (CI) 1.74-5.93] or fluoroquinolones (OR 3.50; 95% CI 1.46-8.37) was associated with MBL-PA infections. Other independent risk factors were neurological disease (OR 3.00; 95% CI 1.61-5.58), urinary tract infection (OR 2.48; 95% CI 1.21-5.09) and renal failure (OR 2.29; 95% CI 1.13-4.65). Admission to hospital 1 (OR 5.97; 95% CI 3.45-14.09) and intensive care unit stay (OR 2.07; 95% CI 1.46-3.96) were also associated with increased risk for MBL-PA infections. CONCLUSIONS: beta-Lactam exposure is an important risk factor for MBL-PA infections even in a setting where patient-to-patient transmission plays a major role in the spread of the isolates. Other risk factors deserve further investigation, particularly exposure to fluoroquinolones.","added-at":"2011-03-11T10:05:34.000+0100","author":["Zavascki","Prehn, Alexandre","Barth","Luís, Afonso","Gaspareto","Barcelos, Patrick","Gonçalves","Saraiva, Ana Lúcia","Moro","Didonet, Ana Lúcia","Fernandes","Fernandez, Juliana","Goldani","Zubaran, Luciano"],"author_short":["Zavascki","Prehn, A.","Barth","Luís, A.","Gaspareto","Barcelos, P.","Gonçalves","Saraiva, A.<nbsp>L.","Moro","Didonet, A.<nbsp>L.","Fernandes","Fernandez, J.","Goldani","Zubaran, L."],"bibtex":"@article{ zavascki_risk_2006,\n abstract = {{OBJECTIVES:} To assess risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase {(MBL-PA)} in two teaching hospitals where horizontal dissemination has been demonstrated. {METHODS:} A case-control study was performed in both hospitals (assigned as hospital 1 and 2). Cases were patients with {MBL-PA} infections and controls were those with {non-MBL-PA} infections. Multivariate analysis was performed to identify independent risk factors. {RESULTS:} A total of 86 cases and 212 controls were included in the study. A logistic regression model showed that exposure to beta-lactams [odds ratio {(OR)} 3.21; 95% confidence interval {(CI)} 1.74-5.93] or fluoroquinolones {(OR} 3.50; 95% {CI} 1.46-8.37) was associated with {MBL-PA} infections. Other independent risk factors were neurological disease {(OR} 3.00; 95% {CI} 1.61-5.58), urinary tract infection {(OR} 2.48; 95% {CI} 1.21-5.09) and renal failure {(OR} 2.29; 95% {CI} 1.13-4.65). Admission to hospital 1 {(OR} 5.97; 95% {CI} 3.45-14.09) and intensive care unit stay {(OR} 2.07; 95% {CI} 1.46-3.96) were also associated with increased risk for {MBL-PA} infections. {CONCLUSIONS:} {beta-Lactam} exposure is an important risk factor for {MBL-PA} infections even in a setting where patient-to-patient transmission plays a major role in the spread of the isolates. Other risk factors deserve further investigation, particularly exposure to fluoroquinolones.},\n added-at = {2011-03-11T10:05:34.000+0100},\n author = {Zavascki, Alexandre Prehn and Barth, Afonso Luís and Gaspareto, Patrick Barcelos and Gonçalves, Ana Lúcia Saraiva and Moro, Ana Lúcia Didonet and Fernandes, Juliana Fernandez and Goldani, Luciano Zubaran},\n biburl = {http://www.bibsonomy.org/bibtex/229811950b972d115db2472556dc63e19/jelias},\n doi = {10.1093/jac/dkl327},\n interhash = {d0c880050355b1532c460930b2f9f056},\n intrahash = {29811950b972d115db2472556dc63e19},\n issn = {0305-7453},\n journal = {The Journal of Antimicrobial Chemotherapy},\n keywords = {Adult, Aged, Agents, Cross Factors Female, Fluoroquinolones, Hospitals, Humans, Incidence, Infection, Infections, Male, Middle Pseudomonas Risk Studies, Teaching, aeruginosa, {Anti-Bacterial} {Case-Control} {beta-Lactamases,} {beta-Lactams,}},\n month = {October},\n note = {{PMID:} 16895936},\n number = {4},\n pages = {882--5},\n title = {Risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase in two tertiary-care teaching hospitals},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/16895936},\n volume = {58},\n year = {2006}\n}","bibtype":"article","biburl":"http://www.bibsonomy.org/bibtex/229811950b972d115db2472556dc63e19/jelias","doi":"10.1093/jac/dkl327","id":"zavascki_risk_2006","interhash":"d0c880050355b1532c460930b2f9f056","intrahash":"29811950b972d115db2472556dc63e19","issn":"0305-7453","journal":"The Journal of Antimicrobial Chemotherapy","key":"zavascki_risk_2006","keywords":"Adult, Aged, Agents, Cross Factors Female, Fluoroquinolones, Hospitals, Humans, Incidence, Infection, Infections, Male, Middle Pseudomonas Risk Studies, Teaching, aeruginosa, Anti-Bacterial Case-Control beta-Lactamases, beta-Lactams,","month":"October","note":"PMID: 16895936","number":"4","pages":"882--5","title":"Risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase in two tertiary-care teaching hospitals","type":"article","url":"http://www.ncbi.nlm.nih.gov/pubmed/16895936","volume":"58","year":"2006","bibbaseid":"zavascki-prehn-barth-lus-gaspareto-barcelos-gonalves-saraiva-moro-didonet-fernandes-fernandez-goldani-zubaran-riskfactorsfornosocomialinfectionsduetopseudomonasaeruginosaproducingmetallobetalactamaseintwotertiarycareteachinghospitals-2006","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/16895936"},"keyword":["Adult","Aged","Agents","Cross Factors Female","Fluoroquinolones","Hospitals","Humans","Incidence","Infection","Infections","Male","Middle Pseudomonas Risk Studies","Teaching","aeruginosa","Anti-Bacterial Case-Control beta-Lactamases","beta-Lactams",""],"downloads":0},"bibtype":"article","biburl":"http://www.bibsonomy.org/bib/author/Afonso?items=1000","creationDate":"2014-12-16T16:10:04.560Z","downloads":0,"keywords":["adult","aged","agents","cross factors female","fluoroquinolones","hospitals","humans","incidence","infection","infections","male","middle pseudomonas risk studies","teaching","aeruginosa","anti-bacterial case-control beta-lactamases","beta-lactams",""],"search_terms":["risk","factors","nosocomial","infections","due","pseudomonas","aeruginosa","producing","metallo","beta","lactamase","two","tertiary","care","teaching","hospitals","zavascki","prehn","barth","luís","gaspareto","barcelos","gonçalves","saraiva","moro","didonet","fernandes","fernandez","goldani","zubaran"],"title":"Risk factors for nosocomial infections due to Pseudomonas aeruginosa producing metallo-beta-lactamase in two tertiary-care teaching hospitals","year":2006,"dataSources":["TeDEwZgcLYbgZSAYJ"]}