Factors associated with meniscal body extrusion on knee MRI in overweight and obese women

Factors associated with meniscal body extrusion on knee MRI in overweight and obese women. Zhang, F., Bierma-Zeinstra, S. M., Oei, E. H. G., Turkiewicz, A., Englund, M., & Runhaar, J.
doi abstract bibtex

OBJECTIVE: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis (OA). DESIGN: We used baseline data of the PROOF study, Netherlands, comprising overweight or obese women aged 50 to 60 years, free of clinical knee OA. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1.5 Tesla MRI of both knees. Using the mid-coronal MRI slice, one blinded observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. The association between baseline factors and meniscal extrusion, were analyzed with a random effects regression model. In addition, we used a fixed effect regression model for evaluation of knee-specific factors. RESULTS: Mean age of the included women (n=395) was 55.7 years and mean body mass index 32.4 kg/m(2). Of all knees, 23% had an absolute medial meniscus body extrusion ≥3.0 mm and 4% had lateral meniscus body extrusion ≥3.0 mm. In the multivariable model, the medial meniscus extrusion was increased by 0.44 mm (95% confidence interval [CI] 0.11, 0.77) when a medial meniscus tear was present, by 0.20 mm per 5 kg/m(2) (95% CI 0.05, 0.35) increase in body mass index and by 0.25 in the presence of mild knee symptoms (95% CI 0.05 to 0.44). Kellgren-Lawrence grade ≥1 and tibia width were associated with increased both medial and lateral extrusion. CONCLUSION: In women, ipsilateral meniscus tear and high body mass index are factors associated with medial meniscus body extrusion.

@article{zhang_factors_2016,
	title = {Factors associated with meniscal body extrusion on knee {MRI} in overweight and obese women},
	issn = {1522-9653},
	doi = {10.1016/j.joca.2016.12.001},
	abstract = {{OBJECTIVE}: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis ({OA}).
{DESIGN}: We used baseline data of the {PROOF} study, Netherlands, comprising overweight or obese women aged 50 to 60 years, free of clinical knee {OA}. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1.5 Tesla {MRI} of both knees. Using the mid-coronal {MRI} slice, one blinded observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. The association between baseline factors and meniscal extrusion, were analyzed with a random effects regression model. In addition, we used a fixed effect regression model for evaluation of knee-specific factors.
{RESULTS}: Mean age of the included women (n=395) was 55.7 years and mean body mass index 32.4 kg/m(2). Of all knees, 23\% had an absolute medial meniscus body extrusion ≥3.0 mm and 4\% had lateral meniscus body extrusion ≥3.0 mm. In the multivariable model, the medial meniscus extrusion was increased by 0.44 mm (95\% confidence interval [{CI}] 0.11, 0.77) when a medial meniscus tear was present, by 0.20 mm per 5 kg/m(2) (95\% {CI} 0.05, 0.35) increase in body mass index and by 0.25 in the presence of mild knee symptoms (95\% {CI} 0.05 to 0.44). Kellgren-Lawrence grade ≥1 and tibia width were associated with increased both medial and lateral extrusion.
{CONCLUSION}: In women, ipsilateral meniscus tear and high body mass index are factors associated with medial meniscus body extrusion.},
	journaltitle = {Osteoarthritis and Cartilage},
	shortjournal = {Osteoarthr. Cartil.},
	author = {Zhang, Fan and Bierma-Zeinstra, Sita M. and Oei, Edwin H. G. and Turkiewicz, Aleksandra and Englund, Martin and Runhaar, Jos},
	date = {2016-12-07},
	pmid = {27939623},
	keywords = {Knee, Magnetic resonance imaging, Meniscus, Osteoarthritis, women}
}

Downloads: 0

{"_id":"4eYEeMyvQLPurvGwD","bibbaseid":"zhang-biermazeinstra-oei-turkiewicz-englund-runhaar-factorsassociatedwithmeniscalbodyextrusiononkneemriinoverweightandobesewomen","downloads":0,"creationDate":"2017-03-31T11:02:36.954Z","title":"Factors associated with meniscal body extrusion on knee MRI in overweight and obese women","author_short":["Zhang, F.","Bierma-Zeinstra, S. M.","Oei, E. H. G.","Turkiewicz, A.","Englund, M.","Runhaar, J."],"year":null,"bibtype":"article","biburl":"http://clinicalepidemiology.se/ClinEpi_LU.bib","bibdata":{"bibtype":"article","type":"article","title":"Factors associated with meniscal body extrusion on knee MRI in overweight and obese women","issn":"1522-9653","doi":"10.1016/j.joca.2016.12.001","abstract":"OBJECTIVE: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis (OA). DESIGN: We used baseline data of the PROOF study, Netherlands, comprising overweight or obese women aged 50 to 60 years, free of clinical knee OA. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1.5 Tesla MRI of both knees. Using the mid-coronal MRI slice, one blinded observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. The association between baseline factors and meniscal extrusion, were analyzed with a random effects regression model. In addition, we used a fixed effect regression model for evaluation of knee-specific factors. RESULTS: Mean age of the included women (n=395) was 55.7 years and mean body mass index 32.4 kg/m(2). Of all knees, 23% had an absolute medial meniscus body extrusion ≥3.0 mm and 4% had lateral meniscus body extrusion ≥3.0 mm. In the multivariable model, the medial meniscus extrusion was increased by 0.44 mm (95% confidence interval [CI] 0.11, 0.77) when a medial meniscus tear was present, by 0.20 mm per 5 kg/m(2) (95% CI 0.05, 0.35) increase in body mass index and by 0.25 in the presence of mild knee symptoms (95% CI 0.05 to 0.44). Kellgren-Lawrence grade ≥1 and tibia width were associated with increased both medial and lateral extrusion. CONCLUSION: In women, ipsilateral meniscus tear and high body mass index are factors associated with medial meniscus body extrusion.","journaltitle":"Osteoarthritis and Cartilage","shortjournal":"Osteoarthr. Cartil.","author":[{"propositions":[],"lastnames":["Zhang"],"firstnames":["Fan"],"suffixes":[]},{"propositions":[],"lastnames":["Bierma-Zeinstra"],"firstnames":["Sita","M."],"suffixes":[]},{"propositions":[],"lastnames":["Oei"],"firstnames":["Edwin","H.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Turkiewicz"],"firstnames":["Aleksandra"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Runhaar"],"firstnames":["Jos"],"suffixes":[]}],"date":"2016-12-07","pmid":"27939623","keywords":"Knee, Magnetic resonance imaging, Meniscus, Osteoarthritis, women","bibtex":"@article{zhang_factors_2016,\n\ttitle = {Factors associated with meniscal body extrusion on knee {MRI} in overweight and obese women},\n\tissn = {1522-9653},\n\tdoi = {10.1016/j.joca.2016.12.001},\n\tabstract = {{OBJECTIVE}: To determine factors associated with higher degree of meniscal body extrusion in overweight and obese women at high risk of knee osteoarthritis ({OA}).\n{DESIGN}: We used baseline data of the {PROOF} study, Netherlands, comprising overweight or obese women aged 50 to 60 years, free of clinical knee {OA}. All subjects completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and 1.5 Tesla {MRI} of both knees. Using the mid-coronal {MRI} slice, one blinded observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. The association between baseline factors and meniscal extrusion, were analyzed with a random effects regression model. In addition, we used a fixed effect regression model for evaluation of knee-specific factors.\n{RESULTS}: Mean age of the included women (n=395) was 55.7 years and mean body mass index 32.4 kg/m(2). Of all knees, 23\\% had an absolute medial meniscus body extrusion ≥3.0 mm and 4\\% had lateral meniscus body extrusion ≥3.0 mm. In the multivariable model, the medial meniscus extrusion was increased by 0.44 mm (95\\% confidence interval [{CI}] 0.11, 0.77) when a medial meniscus tear was present, by 0.20 mm per 5 kg/m(2) (95\\% {CI} 0.05, 0.35) increase in body mass index and by 0.25 in the presence of mild knee symptoms (95\\% {CI} 0.05 to 0.44). Kellgren-Lawrence grade ≥1 and tibia width were associated with increased both medial and lateral extrusion.\n{CONCLUSION}: In women, ipsilateral meniscus tear and high body mass index are factors associated with medial meniscus body extrusion.},\n\tjournaltitle = {Osteoarthritis and Cartilage},\n\tshortjournal = {Osteoarthr. Cartil.},\n\tauthor = {Zhang, Fan and Bierma-Zeinstra, Sita M. and Oei, Edwin H. G. and Turkiewicz, Aleksandra and Englund, Martin and Runhaar, Jos},\n\tdate = {2016-12-07},\n\tpmid = {27939623},\n\tkeywords = {Knee, Magnetic resonance imaging, Meniscus, Osteoarthritis, women}\n}\n\n","author_short":["Zhang, F.","Bierma-Zeinstra, S. M.","Oei, E. H. G.","Turkiewicz, A.","Englund, M.","Runhaar, J."],"key":"zhang_factors_2016","id":"zhang_factors_2016","bibbaseid":"zhang-biermazeinstra-oei-turkiewicz-englund-runhaar-factorsassociatedwithmeniscalbodyextrusiononkneemriinoverweightandobesewomen","role":"author","urls":{},"keyword":["Knee","Magnetic resonance imaging","Meniscus","Osteoarthritis","women"],"downloads":0},"search_terms":["factors","associated","meniscal","body","extrusion","knee","mri","overweight","obese","women","zhang","bierma-zeinstra","oei","turkiewicz","englund","runhaar"],"keywords":["knee","magnetic resonance imaging","meniscus","osteoarthritis","women"],"authorIDs":[],"dataSources":["824aokLfuuJkJwfhw"]}