pH-Responsive Amphiphilic Triblock Fluoropolymers as Assemble Oxygen Nanoshuttles for Enhancing PDT against Hypoxic Tumor. Zhang, J., Haddleton, D., Wilson, P., Zhu, L., Dai, C., & Zhao, L. BIOCONJUGATE CHEMISTRY, 35(3):400–411, February, 2024. Trop Funct Polymer Mat Engn Res Ctr Hainandoi abstract bibtex Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (O-1(2)) to lyse tumor cells. Nevertheless, pre-existing tumor hypoxia and oxygen consumption during PDT can lead to an insufficient oxygen supply, potentially reducing the photodynamic efficacy. In response to this issue, we have devised a pH-responsive amphiphilic triblock fluorinated polymer (PDP) using copper-mediated RDRP. This polymer, composed of poly(ethylene glycol) methyl ether acrylate, 2-(diethylamino)ethyl methacrylate, and (perfluorooctyl)ethyl acrylate, self-assembles in an aqueous environment. Oxygen, chlorine e6 (Ce6), and doxorubicin (DOX) can be codelivered efficiently by PDP. The incorporation of perfluorocarbon into the formulation enhances the oxygen-carrying capacity of PDP, consequently extending the lifetime of O-1(2). This increased lifetime, in turn, amplifies the PDT effect and escalates the cellular cytotoxicity. Compared with PDT alone, PDP@Ce6-DOX-O-2 NPs demonstrated significant inhibition of tumor growth. This study proposes a novel strategy for enhancing the efficacy of PDT.
@article{zhang_ph-responsive_2024,
title = {{pH}-{Responsive} {Amphiphilic} {Triblock} {Fluoropolymers} as {Assemble} {Oxygen} {Nanoshuttles} for {Enhancing} {PDT} against {Hypoxic} {Tumor}},
volume = {35},
issn = {1043-1802},
doi = {10.1021/acs.bioconjchem.4c00029},
abstract = {Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (O-1(2)) to lyse tumor cells. Nevertheless, pre-existing tumor hypoxia and oxygen consumption during PDT can lead to an insufficient oxygen supply, potentially reducing the photodynamic efficacy. In response to this issue, we have devised a pH-responsive amphiphilic triblock fluorinated polymer (PDP) using copper-mediated RDRP. This polymer, composed of poly(ethylene glycol) methyl ether acrylate, 2-(diethylamino)ethyl methacrylate, and (perfluorooctyl)ethyl acrylate, self-assembles in an aqueous environment. Oxygen, chlorine e6 (Ce6), and doxorubicin (DOX) can be codelivered efficiently by PDP. The incorporation of perfluorocarbon into the formulation enhances the oxygen-carrying capacity of PDP, consequently extending the lifetime of O-1(2). This increased lifetime, in turn, amplifies the PDT effect and escalates the cellular cytotoxicity. Compared with PDT alone, PDP@Ce6-DOX-O-2 NPs demonstrated significant inhibition of tumor growth. This study proposes a novel strategy for enhancing the efficacy of PDT.},
number = {3},
urldate = {2024-02-28},
journal = {BIOCONJUGATE CHEMISTRY},
author = {Zhang, Jun-an and Haddleton, David and Wilson, Paul and Zhu, Lin-hua and Dai, Chun-yan and Zhao, Lin-lu},
month = feb,
year = {2024},
note = {Trop Funct Polymer Mat Engn Res Ctr Hainan},
pages = {400--411},
}
Downloads: 0
{"_id":"wK4YCxvk7rz2vRpaA","bibbaseid":"zhang-haddleton-wilson-zhu-dai-zhao-phresponsiveamphiphilictriblockfluoropolymersasassembleoxygennanoshuttlesforenhancingpdtagainsthypoxictumor-2024","author_short":["Zhang, J.","Haddleton, D.","Wilson, P.","Zhu, L.","Dai, C.","Zhao, L."],"bibdata":{"bibtype":"article","type":"article","title":"pH-Responsive Amphiphilic Triblock Fluoropolymers as Assemble Oxygen Nanoshuttles for Enhancing PDT against Hypoxic Tumor","volume":"35","issn":"1043-1802","doi":"10.1021/acs.bioconjchem.4c00029","abstract":"Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (O-1(2)) to lyse tumor cells. Nevertheless, pre-existing tumor hypoxia and oxygen consumption during PDT can lead to an insufficient oxygen supply, potentially reducing the photodynamic efficacy. In response to this issue, we have devised a pH-responsive amphiphilic triblock fluorinated polymer (PDP) using copper-mediated RDRP. This polymer, composed of poly(ethylene glycol) methyl ether acrylate, 2-(diethylamino)ethyl methacrylate, and (perfluorooctyl)ethyl acrylate, self-assembles in an aqueous environment. Oxygen, chlorine e6 (Ce6), and doxorubicin (DOX) can be codelivered efficiently by PDP. The incorporation of perfluorocarbon into the formulation enhances the oxygen-carrying capacity of PDP, consequently extending the lifetime of O-1(2). This increased lifetime, in turn, amplifies the PDT effect and escalates the cellular cytotoxicity. Compared with PDT alone, PDP@Ce6-DOX-O-2 NPs demonstrated significant inhibition of tumor growth. This study proposes a novel strategy for enhancing the efficacy of PDT.","number":"3","urldate":"2024-02-28","journal":"BIOCONJUGATE CHEMISTRY","author":[{"propositions":[],"lastnames":["Zhang"],"firstnames":["Jun-an"],"suffixes":[]},{"propositions":[],"lastnames":["Haddleton"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Wilson"],"firstnames":["Paul"],"suffixes":[]},{"propositions":[],"lastnames":["Zhu"],"firstnames":["Lin-hua"],"suffixes":[]},{"propositions":[],"lastnames":["Dai"],"firstnames":["Chun-yan"],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["Lin-lu"],"suffixes":[]}],"month":"February","year":"2024","note":"Trop Funct Polymer Mat Engn Res Ctr Hainan","pages":"400–411","bibtex":"@article{zhang_ph-responsive_2024,\n\ttitle = {{pH}-{Responsive} {Amphiphilic} {Triblock} {Fluoropolymers} as {Assemble} {Oxygen} {Nanoshuttles} for {Enhancing} {PDT} against {Hypoxic} {Tumor}},\n\tvolume = {35},\n\tissn = {1043-1802},\n\tdoi = {10.1021/acs.bioconjchem.4c00029},\n\tabstract = {Photodynamic therapy (PDT) is a cancer treatment strategy that utilizes photosensitizers to convert oxygen within tumors into reactive singlet oxygen (O-1(2)) to lyse tumor cells. Nevertheless, pre-existing tumor hypoxia and oxygen consumption during PDT can lead to an insufficient oxygen supply, potentially reducing the photodynamic efficacy. In response to this issue, we have devised a pH-responsive amphiphilic triblock fluorinated polymer (PDP) using copper-mediated RDRP. This polymer, composed of poly(ethylene glycol) methyl ether acrylate, 2-(diethylamino)ethyl methacrylate, and (perfluorooctyl)ethyl acrylate, self-assembles in an aqueous environment. Oxygen, chlorine e6 (Ce6), and doxorubicin (DOX) can be codelivered efficiently by PDP. The incorporation of perfluorocarbon into the formulation enhances the oxygen-carrying capacity of PDP, consequently extending the lifetime of O-1(2). This increased lifetime, in turn, amplifies the PDT effect and escalates the cellular cytotoxicity. Compared with PDT alone, PDP@Ce6-DOX-O-2 NPs demonstrated significant inhibition of tumor growth. This study proposes a novel strategy for enhancing the efficacy of PDT.},\n\tnumber = {3},\n\turldate = {2024-02-28},\n\tjournal = {BIOCONJUGATE CHEMISTRY},\n\tauthor = {Zhang, Jun-an and Haddleton, David and Wilson, Paul and Zhu, Lin-hua and Dai, Chun-yan and Zhao, Lin-lu},\n\tmonth = feb,\n\tyear = {2024},\n\tnote = {Trop Funct Polymer Mat Engn Res Ctr Hainan},\n\tpages = {400--411},\n}\n\n","author_short":["Zhang, J.","Haddleton, D.","Wilson, P.","Zhu, L.","Dai, C.","Zhao, L."],"key":"zhang_ph-responsive_2024","id":"zhang_ph-responsive_2024","bibbaseid":"zhang-haddleton-wilson-zhu-dai-zhao-phresponsiveamphiphilictriblockfluoropolymersasassembleoxygennanoshuttlesforenhancingpdtagainsthypoxictumor-2024","role":"author","urls":{},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://warwick.ac.uk/fac/cross_fac/wesic/research/wpg/research/WPGsep2024.bib","dataSources":["m4fxWT6XKrYfGbZFR","GBhqMC9hjyD5vqptk","6idaYK6okJY39mWgG"],"keywords":[],"search_terms":["responsive","amphiphilic","triblock","fluoropolymers","assemble","oxygen","nanoshuttles","enhancing","pdt","against","hypoxic","tumor","zhang","haddleton","wilson","zhu","dai","zhao"],"title":"pH-Responsive Amphiphilic Triblock Fluoropolymers as Assemble Oxygen Nanoshuttles for Enhancing PDT against Hypoxic Tumor","year":2024}