An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants. Zhang, T. Q., Lian, H., Tang, H., Dolezal, K., Zhou, C. M., Yu, S., Chen, J. H., Chen, Q., Liu, H., Ljung, K., & Wang, J. W. Plant Cell, 27(2):349–60, February, 2015. Edition: 2015/02/05![An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Plant cells are totipotent and competent to regenerate from differentiated organs. It has been shown that two phytohormones, auxin and cytokinin, play critical roles within this process. As in animals, the regenerative capacity declines with age in plants, but the molecular basis for this phenomenon remains elusive. Here, we demonstrate that an age-regulated microRNA, miR156, regulates shoot regenerative capacity. As a plant ages, the gradual increase in miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors leads to the progressive decline in shoot regenerative capacity. In old plants, SPL reduces shoot regenerative capacity by attenuating the cytokinin response through binding with the B-type ARABIDOPSIS RESPONSE REGULATORs, which encode the transcriptional activators in the cytokinin signaling pathway. Consistently, the increased amount of exogenous cytokinin complements the reduced shoot regenerative capacity in old plants. Therefore, the recruitment of age cues in response to cytokinin contributes to shoot regenerative competence.
@article{zhang_intrinsic_2015,
title = {An intrinsic {microRNA} timer regulates progressive decline in shoot regenerative capacity in plants},
volume = {27},
issn = {1532-298X (Electronic) 1040-4651 (Linking)},
url = {https://www.ncbi.nlm.nih.gov/pubmed/25649435},
doi = {10.1105/tpc.114.135186},
abstract = {Plant cells are totipotent and competent to regenerate from differentiated organs. It has been shown that two phytohormones, auxin and cytokinin, play critical roles within this process. As in animals, the regenerative capacity declines with age in plants, but the molecular basis for this phenomenon remains elusive. Here, we demonstrate that an age-regulated microRNA, miR156, regulates shoot regenerative capacity. As a plant ages, the gradual increase in miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors leads to the progressive decline in shoot regenerative capacity. In old plants, SPL reduces shoot regenerative capacity by attenuating the cytokinin response through binding with the B-type ARABIDOPSIS RESPONSE REGULATORs, which encode the transcriptional activators in the cytokinin signaling pathway. Consistently, the increased amount of exogenous cytokinin complements the reduced shoot regenerative capacity in old plants. Therefore, the recruitment of age cues in response to cytokinin contributes to shoot regenerative competence.},
language = {en},
number = {2},
urldate = {2021-06-07},
journal = {Plant Cell},
author = {Zhang, T. Q. and Lian, H. and Tang, H. and Dolezal, K. and Zhou, C. M. and Yu, S. and Chen, J. H. and Chen, Q. and Liu, H. and Ljung, K. and Wang, J. W.},
month = feb,
year = {2015},
note = {Edition: 2015/02/05},
keywords = {Arabidopsis/genetics/*physiology, Cytokinins/pharmacology, Genes, Plant, MicroRNAs/genetics/*metabolism, Plant Proteins/metabolism, Plant Shoots/*genetics/*physiology, Regeneration/*genetics, Tobacco/genetics/*physiology},
pages = {349--60},
}
Downloads: 0
{"_id":"LYTgXP2exvn5aARDF","bibbaseid":"zhang-lian-tang-dolezal-zhou-yu-chen-chen-etal-anintrinsicmicrornatimerregulatesprogressivedeclineinshootregenerativecapacityinplants-2015","author_short":["Zhang, T. Q.","Lian, H.","Tang, H.","Dolezal, K.","Zhou, C. M.","Yu, S.","Chen, J. H.","Chen, Q.","Liu, H.","Ljung, K.","Wang, J. W."],"bibdata":{"bibtype":"article","type":"article","title":"An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants","volume":"27","issn":"1532-298X (Electronic) 1040-4651 (Linking)","url":"https://www.ncbi.nlm.nih.gov/pubmed/25649435","doi":"10.1105/tpc.114.135186","abstract":"Plant cells are totipotent and competent to regenerate from differentiated organs. It has been shown that two phytohormones, auxin and cytokinin, play critical roles within this process. As in animals, the regenerative capacity declines with age in plants, but the molecular basis for this phenomenon remains elusive. Here, we demonstrate that an age-regulated microRNA, miR156, regulates shoot regenerative capacity. As a plant ages, the gradual increase in miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors leads to the progressive decline in shoot regenerative capacity. In old plants, SPL reduces shoot regenerative capacity by attenuating the cytokinin response through binding with the B-type ARABIDOPSIS RESPONSE REGULATORs, which encode the transcriptional activators in the cytokinin signaling pathway. Consistently, the increased amount of exogenous cytokinin complements the reduced shoot regenerative capacity in old plants. Therefore, the recruitment of age cues in response to cytokinin contributes to shoot regenerative competence.","language":"en","number":"2","urldate":"2021-06-07","journal":"Plant Cell","author":[{"propositions":[],"lastnames":["Zhang"],"firstnames":["T.","Q."],"suffixes":[]},{"propositions":[],"lastnames":["Lian"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Tang"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Dolezal"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Zhou"],"firstnames":["C.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Yu"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["J.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Q."],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Ljung"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["J.","W."],"suffixes":[]}],"month":"February","year":"2015","note":"Edition: 2015/02/05","keywords":"Arabidopsis/genetics/*physiology, Cytokinins/pharmacology, Genes, Plant, MicroRNAs/genetics/*metabolism, Plant Proteins/metabolism, Plant Shoots/*genetics/*physiology, Regeneration/*genetics, Tobacco/genetics/*physiology","pages":"349–60","bibtex":"@article{zhang_intrinsic_2015,\n\ttitle = {An intrinsic {microRNA} timer regulates progressive decline in shoot regenerative capacity in plants},\n\tvolume = {27},\n\tissn = {1532-298X (Electronic) 1040-4651 (Linking)},\n\turl = {https://www.ncbi.nlm.nih.gov/pubmed/25649435},\n\tdoi = {10.1105/tpc.114.135186},\n\tabstract = {Plant cells are totipotent and competent to regenerate from differentiated organs. It has been shown that two phytohormones, auxin and cytokinin, play critical roles within this process. As in animals, the regenerative capacity declines with age in plants, but the molecular basis for this phenomenon remains elusive. Here, we demonstrate that an age-regulated microRNA, miR156, regulates shoot regenerative capacity. As a plant ages, the gradual increase in miR156-targeted SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors leads to the progressive decline in shoot regenerative capacity. In old plants, SPL reduces shoot regenerative capacity by attenuating the cytokinin response through binding with the B-type ARABIDOPSIS RESPONSE REGULATORs, which encode the transcriptional activators in the cytokinin signaling pathway. Consistently, the increased amount of exogenous cytokinin complements the reduced shoot regenerative capacity in old plants. Therefore, the recruitment of age cues in response to cytokinin contributes to shoot regenerative competence.},\n\tlanguage = {en},\n\tnumber = {2},\n\turldate = {2021-06-07},\n\tjournal = {Plant Cell},\n\tauthor = {Zhang, T. Q. and Lian, H. and Tang, H. and Dolezal, K. and Zhou, C. M. and Yu, S. and Chen, J. H. and Chen, Q. and Liu, H. and Ljung, K. and Wang, J. W.},\n\tmonth = feb,\n\tyear = {2015},\n\tnote = {Edition: 2015/02/05},\n\tkeywords = {Arabidopsis/genetics/*physiology, Cytokinins/pharmacology, Genes, Plant, MicroRNAs/genetics/*metabolism, Plant Proteins/metabolism, Plant Shoots/*genetics/*physiology, Regeneration/*genetics, Tobacco/genetics/*physiology},\n\tpages = {349--60},\n}\n\n","author_short":["Zhang, T. Q.","Lian, H.","Tang, H.","Dolezal, K.","Zhou, C. M.","Yu, S.","Chen, J. H.","Chen, Q.","Liu, H.","Ljung, K.","Wang, J. W."],"key":"zhang_intrinsic_2015","id":"zhang_intrinsic_2015","bibbaseid":"zhang-lian-tang-dolezal-zhou-yu-chen-chen-etal-anintrinsicmicrornatimerregulatesprogressivedeclineinshootregenerativecapacityinplants-2015","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/25649435"},"keyword":["Arabidopsis/genetics/*physiology","Cytokinins/pharmacology","Genes","Plant","MicroRNAs/genetics/*metabolism","Plant Proteins/metabolism","Plant Shoots/*genetics/*physiology","Regeneration/*genetics","Tobacco/genetics/*physiology"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/upscpub","dataSources":["NBc5535umsZRkycsp","pt97f4NqLPmFSfPfg","3bgRArTPQuMzE5oHo","i3dSpgkW42rSpQiks","3H2zfWvYzAbTMWnKu","77QZ74DvQXSZvKNjP","9cGcv2t8pRzC92kzs","fvfkWcShg3Mybjoog","Tu3jPdZyJF3j547xT"],"keywords":["arabidopsis/genetics/*physiology","cytokinins/pharmacology","genes","plant","micrornas/genetics/*metabolism","plant proteins/metabolism","plant shoots/*genetics/*physiology","regeneration/*genetics","tobacco/genetics/*physiology"],"search_terms":["intrinsic","microrna","timer","regulates","progressive","decline","shoot","regenerative","capacity","plants","zhang","lian","tang","dolezal","zhou","yu","chen","chen","liu","ljung","wang"],"title":"An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants","year":2015}