@article{zhang_design_2006,
	title = {Design of {Biocompatible} {Chitosan} {Microgels} for {Targeted} {pH}-{Mediated} {Intracellular} {Release} of {Cancer} {Therapeutics}},
	volume = {7},
	issn = {1525-7797},
	url = {https://doi.org/10.1021/bm050912z},
	doi = {10.1021/bm050912z},
	abstract = {We report the rational design of a chitosan-based drug delivery system. The chitosan derivative N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan chloride (HTCC) was ionically cross-linked by sodium tripolyphosphate (TPP) to form sub-200-nm microgels that are responsive to pH changes. When these microgels were loaded with methotrexate disodium (MTX), a cytotoxic drug for cancer treatment, and conjugated to the targeting biomolecule apo-transferrin, a protein known to enter cells via receptor-mediated endocytosis, enhanced killing of immortalized HeLa cells was observed. In this intracellular delivery method, the microgel was exposed to low-pH environments that caused the chitosan to swell and release the drug. This rational drug delivery design may be useful in enhancing cancer therapy and reducing side effects.},
	number = {5},
	urldate = {2021-11-06},
	journal = {Biomacromolecules},
	author = {Zhang, Hong and Mardyani, Sawitri and Chan, Warren C. W. and Kumacheva, Eugenia},
	month = may,
	year = {2006},
	note = {Publisher: American Chemical Society},
	pages = {1568--1572},
	file = {Full Text PDF:files/2238/Zhang et al. - 2006 - Design of Biocompatible Chitosan Microgels for Tar.pdf:application/pdf;ACS Full Text Snapshot:files/2242/bm050912z.html:text/html},
	url_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/bm050912z.pdf}
}

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