@article{zhang_nanoparticleliver_2016,
	series = {{SI}: {North} {America} {Part} {II}},
	title = {Nanoparticle–liver interactions: {Cellular} uptake and hepatobiliary elimination},
	volume = {240},
	issn = {0168-3659},
	shorttitle = {Nanoparticle–liver interactions},
	url = {https://www.sciencedirect.com/science/article/pii/S0168365916300190},
	doi = {10.1016/j.jconrel.2016.01.020},
	abstract = {30–99\% of administered nanoparticles will accumulate and sequester in the liver after administration into the body. This results in reduced delivery to the targeted diseased tissue and potentially leads to increased toxicity at the hepatic cellular level. This review article focuses on the inter- and intra-cellular interaction between nanoparticles and hepatic cells, the elimination mechanism of nanoparticles through the hepatobiliary system, and current strategies to manipulate liver sequestration. The ability to solve the “nanoparticle-liver” interaction is critical to the clinical translation of nanotechnology for diagnosing and treating cancer, diabetes, cardiovascular disorders, and other diseases.},
	language = {en},
	urldate = {2021-11-06},
	journal = {Journal of Controlled Release},
	author = {Zhang, Yi-Nan and Poon, Wilson and Tavares, Anthony J. and McGilvray, Ian D. and Chan, Warren C. W.},
	month = oct,
	year = {2016},
	keywords = {Hepatobiliary clearance, Liver, Macrophage, Nanoparticle},
	pages = {332--348},
	file = {ScienceDirect Full Text PDF:files/1947/Zhang et al. - 2016 - Nanoparticle–liver interactions Cellular uptake a.pdf:application/pdf},
	url_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/1-s2.0-S0168365916300190-main-min.pdf}
}

{"_id":"P77RgXYAKgHpLfyvq","bibbaseid":"zhang-poon-tavares-mcgilvray-chan-nanoparticleliverinteractionscellularuptakeandhepatobiliaryelimination-2016","author_short":["Zhang, Y.","Poon, W.","Tavares, A. J.","McGilvray, I. D.","Chan, W. C. W."],"bibdata":{"bibtype":"article","type":"article","series":"SI: North America Part II","title":"Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination","volume":"240","issn":"0168-3659","shorttitle":"Nanoparticle–liver interactions","url":"https://www.sciencedirect.com/science/article/pii/S0168365916300190","doi":"10.1016/j.jconrel.2016.01.020","abstract":"30–99% of administered nanoparticles will accumulate and sequester in the liver after administration into the body. This results in reduced delivery to the targeted diseased tissue and potentially leads to increased toxicity at the hepatic cellular level. This review article focuses on the inter- and intra-cellular interaction between nanoparticles and hepatic cells, the elimination mechanism of nanoparticles through the hepatobiliary system, and current strategies to manipulate liver sequestration. The ability to solve the “nanoparticle-liver” interaction is critical to the clinical translation of nanotechnology for diagnosing and treating cancer, diabetes, cardiovascular disorders, and other diseases.","language":"en","urldate":"2021-11-06","journal":"Journal of Controlled Release","author":[{"propositions":[],"lastnames":["Zhang"],"firstnames":["Yi-Nan"],"suffixes":[]},{"propositions":[],"lastnames":["Poon"],"firstnames":["Wilson"],"suffixes":[]},{"propositions":[],"lastnames":["Tavares"],"firstnames":["Anthony","J."],"suffixes":[]},{"propositions":[],"lastnames":["McGilvray"],"firstnames":["Ian","D."],"suffixes":[]},{"propositions":[],"lastnames":["Chan"],"firstnames":["Warren","C.","W."],"suffixes":[]}],"month":"October","year":"2016","keywords":"Hepatobiliary clearance, Liver, Macrophage, Nanoparticle","pages":"332–348","file":"ScienceDirect Full Text PDF:files/1947/Zhang et al. - 2016 - Nanoparticle–liver interactions Cellular uptake a.pdf:application/pdf","url_paper":"https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/1-s2.0-S0168365916300190-main-min.pdf","bibtex":"@article{zhang_nanoparticleliver_2016,\n\tseries = {{SI}: {North} {America} {Part} {II}},\n\ttitle = {Nanoparticle–liver interactions: {Cellular} uptake and hepatobiliary elimination},\n\tvolume = {240},\n\tissn = {0168-3659},\n\tshorttitle = {Nanoparticle–liver interactions},\n\turl = {https://www.sciencedirect.com/science/article/pii/S0168365916300190},\n\tdoi = {10.1016/j.jconrel.2016.01.020},\n\tabstract = {30–99\\% of administered nanoparticles will accumulate and sequester in the liver after administration into the body. This results in reduced delivery to the targeted diseased tissue and potentially leads to increased toxicity at the hepatic cellular level. This review article focuses on the inter- and intra-cellular interaction between nanoparticles and hepatic cells, the elimination mechanism of nanoparticles through the hepatobiliary system, and current strategies to manipulate liver sequestration. The ability to solve the “nanoparticle-liver” interaction is critical to the clinical translation of nanotechnology for diagnosing and treating cancer, diabetes, cardiovascular disorders, and other diseases.},\n\tlanguage = {en},\n\turldate = {2021-11-06},\n\tjournal = {Journal of Controlled Release},\n\tauthor = {Zhang, Yi-Nan and Poon, Wilson and Tavares, Anthony J. and McGilvray, Ian D. and Chan, Warren C. W.},\n\tmonth = oct,\n\tyear = {2016},\n\tkeywords = {Hepatobiliary clearance, Liver, Macrophage, Nanoparticle},\n\tpages = {332--348},\n\tfile = {ScienceDirect Full Text PDF:files/1947/Zhang et al. - 2016 - Nanoparticle–liver interactions Cellular uptake a.pdf:application/pdf},\n\turl_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/1-s2.0-S0168365916300190-main-min.pdf}\n}\n\n","author_short":["Zhang, Y.","Poon, W.","Tavares, A. J.","McGilvray, I. D.","Chan, W. C. W."],"key":"zhang_nanoparticleliver_2016","id":"zhang_nanoparticleliver_2016","bibbaseid":"zhang-poon-tavares-mcgilvray-chan-nanoparticleliverinteractionscellularuptakeandhepatobiliaryelimination-2016","role":"author","urls":{"Paper":"https://www.sciencedirect.com/science/article/pii/S0168365916300190"," paper":"https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/1-s2.0-S0168365916300190-main-min.pdf"},"keyword":["Hepatobiliary clearance","Liver","Macrophage","Nanoparticle"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://inbslab.com//wp-content/uploads/2024/03/Chan-2024_03-14.txt","dataSources":["zb3p4i4Fd9wXynbkF","pF7M3AvRzd8m3Nc5t","BqtRhZTYdfYNLhWzp","sBWiDMMhfDHZnN93b","zkBeHFgTXc62hytzj","s3xwaPmQ7EjjEcMSb","5npqWkz6DHBZLyn3J","yc5dXnBwovT8YvCrt","nLduyq7S9B96QB8B5","JiWrSgLBTKbDLqiYi"],"keywords":["hepatobiliary clearance","liver","macrophage","nanoparticle"],"search_terms":["nanoparticle","liver","interactions","cellular","uptake","hepatobiliary","elimination","zhang","poon","tavares","mcgilvray","chan"],"title":"Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination","year":2016,"downloads":1}