@article{zhang_amoxicillin/clavulanic_2011,
	title = {Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial},
	volume = {71},
	issn = {0306-5251},
	shorttitle = {Amoxicillin/clavulanic acid-warfarin drug interaction},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040543/},
	doi = {10.1111/j.1365-2125.2010.03824.x},
	abstract = {AIMS
To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.

METHODS
In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.

RESULTS
The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P= 0.94). The day 7–day 1 factor II, R(–) and S(–) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P= 0.81, P= 0.45, P= 0.75, respectively).

CONCLUSION
Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.},
	number = {2},
	urldate = {2014-06-25TZ},
	journal = {British Journal of Clinical Pharmacology},
	author = {Zhang, Qian and Simoneau, Guy and Verstuyft, Celine and Drouet, Ludovic and dit Sollier, Claire Bal and Alvarez, Jean-Claude and Rizzo-Padoin, Nathalie and Bergmann, Jean Francois and Becquemont, Laurent and Mouly, Stephane},
	month = feb,
	year = {2011},
	pmid = {21219403},
	pmcid = {PMC3040543},
	keywords = {Adult, Aged, Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Anticoagulants, Blood Coagulation, Cross-Over Studies, Double-Blind Method, Drug Interactions, Female, Humans, International Normalized Ratio, Male, Middle Aged, Prothrombin, Warfarin, Young Adult},
	pages = {232--236}
}

{"_id":"3b488DMSTgjrzbgT6","bibbaseid":"zhang-simoneau-verstuyft-drouet-ditsollier-alvarez-rizzopadoin-bergmann-etal-amoxicillinclavulanicacidwarfarindruginteractionarandomizedcontrolledtrial-2011","downloads":0,"creationDate":"2018-12-05T13:23:19.978Z","title":"Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial","author_short":["Zhang, Q.","Simoneau, G.","Verstuyft, C.","Drouet, L.","dit Sollier, C. B.","Alvarez, J.","Rizzo-Padoin, N.","Bergmann, J. F.","Becquemont, L.","Mouly, S."],"year":2011,"bibtype":"article","biburl":"https://bibbase.org/zotero/emmanuel.chazard","bibdata":{"bibtype":"article","type":"article","title":"Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial","volume":"71","issn":"0306-5251","shorttitle":"Amoxicillin/clavulanic acid-warfarin drug interaction","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040543/","doi":"10.1111/j.1365-2125.2010.03824.x","abstract":"AIMS To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy. METHODS In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo. RESULTS The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P= 0.94). The day 7–day 1 factor II, R(–) and S(–) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P= 0.81, P= 0.45, P= 0.75, respectively). CONCLUSION Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.","number":"2","urldate":"2014-06-25TZ","journal":"British Journal of Clinical Pharmacology","author":[{"propositions":[],"lastnames":["Zhang"],"firstnames":["Qian"],"suffixes":[]},{"propositions":[],"lastnames":["Simoneau"],"firstnames":["Guy"],"suffixes":[]},{"propositions":[],"lastnames":["Verstuyft"],"firstnames":["Celine"],"suffixes":[]},{"propositions":[],"lastnames":["Drouet"],"firstnames":["Ludovic"],"suffixes":[]},{"propositions":["dit"],"lastnames":["Sollier"],"firstnames":["Claire","Bal"],"suffixes":[]},{"propositions":[],"lastnames":["Alvarez"],"firstnames":["Jean-Claude"],"suffixes":[]},{"propositions":[],"lastnames":["Rizzo-Padoin"],"firstnames":["Nathalie"],"suffixes":[]},{"propositions":[],"lastnames":["Bergmann"],"firstnames":["Jean","Francois"],"suffixes":[]},{"propositions":[],"lastnames":["Becquemont"],"firstnames":["Laurent"],"suffixes":[]},{"propositions":[],"lastnames":["Mouly"],"firstnames":["Stephane"],"suffixes":[]}],"month":"February","year":"2011","pmid":"21219403","pmcid":"PMC3040543","keywords":"Adult, Aged, Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Anticoagulants, Blood Coagulation, Cross-Over Studies, Double-Blind Method, Drug Interactions, Female, Humans, International Normalized Ratio, Male, Middle Aged, Prothrombin, Warfarin, Young Adult","pages":"232–236","bibtex":"@article{zhang_amoxicillin/clavulanic_2011,\n\ttitle = {Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial},\n\tvolume = {71},\n\tissn = {0306-5251},\n\tshorttitle = {Amoxicillin/clavulanic acid-warfarin drug interaction},\n\turl = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040543/},\n\tdoi = {10.1111/j.1365-2125.2010.03824.x},\n\tabstract = {AIMS\nTo investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.\n\nMETHODS\nIn a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.\n\nRESULTS\nThe mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P= 0.94). The day 7–day 1 factor II, R(–) and S(–) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P= 0.81, P= 0.45, P= 0.75, respectively).\n\nCONCLUSION\nAmoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.},\n\tnumber = {2},\n\turldate = {2014-06-25TZ},\n\tjournal = {British Journal of Clinical Pharmacology},\n\tauthor = {Zhang, Qian and Simoneau, Guy and Verstuyft, Celine and Drouet, Ludovic and dit Sollier, Claire Bal and Alvarez, Jean-Claude and Rizzo-Padoin, Nathalie and Bergmann, Jean Francois and Becquemont, Laurent and Mouly, Stephane},\n\tmonth = feb,\n\tyear = {2011},\n\tpmid = {21219403},\n\tpmcid = {PMC3040543},\n\tkeywords = {Adult, Aged, Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Anticoagulants, Blood Coagulation, Cross-Over Studies, Double-Blind Method, Drug Interactions, Female, Humans, International Normalized Ratio, Male, Middle Aged, Prothrombin, Warfarin, Young Adult},\n\tpages = {232--236}\n}\n\n","author_short":["Zhang, Q.","Simoneau, G.","Verstuyft, C.","Drouet, L.","dit Sollier, C. B.","Alvarez, J.","Rizzo-Padoin, N.","Bergmann, J. 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