@article{RN227,
   author = {Zhang, C. E. and Wong, S. M. and Uiterwijk, R. and Backes, W. H. and Jansen, J. F. A. and Jeukens, Crlpn and van Oostenbrugge, R. J. and Staals, J.},
   title = {Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging},
   journal = {Brain Imaging Behav},
   volume = {13},
   number = {2},
   pages = {389-395},
   note = {Zhang, C Eleana
Wong, Sau May
Uiterwijk, Renske
Backes, Walter H
Jansen, Jacobus F A
Jeukens, Cecile R L P N
van Oostenbrugge, Robert J
Staals, Julie
eng
666881/European Union's Horizon 2020
017.009.048/Nederlandse Organisatie voor Wetenschappelijk Onderzoek
2013(1)-195/Hersenstichting
2018/03/25 06:00
Brain Imaging Behav. 2019 Apr;13(2):389-395. doi: 10.1007/s11682-018-9855-7.},
   abstract = {Blood-brain barrier (BBB) leakage increases with age and is involved in the pathophysiology of cerebral small vessel disease (cSVD). We examined the relationship between BBB leakage and white matter hyperintensity (WMH) volume and cognition, in cSVD patients and healthy controls. Seventy-seven patients with clinically overt cSVD and thirty-nine age matched healthy controls underwent dynamic contract-enhanced and structural brain MRI and neuropsychological assessment. We quantified BBB leakage volume and rate in normal appearing white matter (NAWM), WMH and cortical grey matter (CGM). Larger leakage volume and lower leakage rate in WMH were associated with larger WMH volume in cSVD but not in controls. Higher leakage rate in NAWM was associated with lower scores on executive function and information processing speed in healthy controls, whereas no relation with cognition was found in cSVD patients. Our findings support the involvement of BBB leakage in cSVD and aging. They also suggest that the mechanism of cognitive dysfunction in cSVD is more complex and multifactorial in cSVD compared with normal aging.},
   keywords = {Aged
Aging/*metabolism
Blood-Brain Barrier/*diagnostic imaging/*physiopathology
Cerebral Small Vessel Diseases/*diagnostic imaging/*physiopathology
Female
Gray Matter/diagnostic imaging/physiopathology
Humans
Magnetic Resonance Imaging
Male
White Matter/*diagnostic imaging/*physiopathology
Blood-brain barrier
Cerebral small vessel disease
Cognition
Mri
White matter hyperintensities},
   ISSN = {1931-7565 (Electronic)
1931-7557 (Linking)},
   DOI = {10.1007/s11682-018-9855-7},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/29572621
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486901/pdf/11682_2018_Article_9855.pdf},
   year = {2019},
   type = {Journal Article}
}

{"_id":"4wiMSThZXemGFNqXn","bibbaseid":"zhang-wong-uiterwijk-backes-jansen-jeukens-vanoostenbrugge-staals-bloodbrainbarrierleakageinrelationtowhitematterhyperintensityvolumeandcognitioninsmallvesseldiseaseandnormalaging-2019","authorIDs":["9uYiZAT4SGYEdwuhG","CHX5tw5dNmS7tFMt9","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","Jeci2sNzJiMSDeJvc","QqoDaykDZWJd9YuAu","TEAWLnKpXtQE8hs6C","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","rQrciQZhPyL9ovwM8","zTR82AHQxLXLWt4wi"],"author_short":["Zhang, C. E.","Wong, S. M.","Uiterwijk, R.","Backes, W. H.","Jansen, J. F. A.","Jeukens, C.","van Oostenbrugge, R. J.","Staals, J."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Zhang"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Uiterwijk"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Jeukens"],"firstnames":["Crlpn"],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]}],"title":"Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging","journal":"Brain Imaging Behav","volume":"13","number":"2","pages":"389-395","note":"Zhang, C Eleana Wong, Sau May Uiterwijk, Renske Backes, Walter H Jansen, Jacobus F A Jeukens, Cecile R L P N van Oostenbrugge, Robert J Staals, Julie eng 666881/European Union's Horizon 2020 017.009.048/Nederlandse Organisatie voor Wetenschappelijk Onderzoek 2013(1)-195/Hersenstichting 2018/03/25 06:00 Brain Imaging Behav. 2019 Apr;13(2):389-395. doi: 10.1007/s11682-018-9855-7.","abstract":"Blood-brain barrier (BBB) leakage increases with age and is involved in the pathophysiology of cerebral small vessel disease (cSVD). We examined the relationship between BBB leakage and white matter hyperintensity (WMH) volume and cognition, in cSVD patients and healthy controls. Seventy-seven patients with clinically overt cSVD and thirty-nine age matched healthy controls underwent dynamic contract-enhanced and structural brain MRI and neuropsychological assessment. We quantified BBB leakage volume and rate in normal appearing white matter (NAWM), WMH and cortical grey matter (CGM). Larger leakage volume and lower leakage rate in WMH were associated with larger WMH volume in cSVD but not in controls. Higher leakage rate in NAWM was associated with lower scores on executive function and information processing speed in healthy controls, whereas no relation with cognition was found in cSVD patients. Our findings support the involvement of BBB leakage in cSVD and aging. They also suggest that the mechanism of cognitive dysfunction in cSVD is more complex and multifactorial in cSVD compared with normal aging.","keywords":"Aged Aging/*metabolism Blood-Brain Barrier/*diagnostic imaging/*physiopathology Cerebral Small Vessel Diseases/*diagnostic imaging/*physiopathology Female Gray Matter/diagnostic imaging/physiopathology Humans Magnetic Resonance Imaging Male White Matter/*diagnostic imaging/*physiopathology Blood-brain barrier Cerebral small vessel disease Cognition Mri White matter hyperintensities","issn":"1931-7565 (Electronic) 1931-7557 (Linking)","doi":"10.1007/s11682-018-9855-7","url":"http://www.ncbi.nlm.nih.gov/pubmed/29572621 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486901/pdf/11682_2018_Article_9855.pdf","year":"2019","bibtex":"@article{RN227,\n author = {Zhang, C. E. and Wong, S. M. and Uiterwijk, R. and Backes, W. H. and Jansen, J. F. A. and Jeukens, Crlpn and van Oostenbrugge, R. J. and Staals, J.},\n title = {Blood-brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging},\n journal = {Brain Imaging Behav},\n volume = {13},\n number = {2},\n pages = {389-395},\n note = {Zhang, C Eleana\nWong, Sau May\nUiterwijk, Renske\nBackes, Walter H\nJansen, Jacobus F A\nJeukens, Cecile R L P N\nvan Oostenbrugge, Robert J\nStaals, Julie\neng\n666881/European Union's Horizon 2020\n017.009.048/Nederlandse Organisatie voor Wetenschappelijk Onderzoek\n2013(1)-195/Hersenstichting\n2018/03/25 06:00\nBrain Imaging Behav. 2019 Apr;13(2):389-395. doi: 10.1007/s11682-018-9855-7.},\n abstract = {Blood-brain barrier (BBB) leakage increases with age and is involved in the pathophysiology of cerebral small vessel disease (cSVD). We examined the relationship between BBB leakage and white matter hyperintensity (WMH) volume and cognition, in cSVD patients and healthy controls. Seventy-seven patients with clinically overt cSVD and thirty-nine age matched healthy controls underwent dynamic contract-enhanced and structural brain MRI and neuropsychological assessment. We quantified BBB leakage volume and rate in normal appearing white matter (NAWM), WMH and cortical grey matter (CGM). Larger leakage volume and lower leakage rate in WMH were associated with larger WMH volume in cSVD but not in controls. Higher leakage rate in NAWM was associated with lower scores on executive function and information processing speed in healthy controls, whereas no relation with cognition was found in cSVD patients. Our findings support the involvement of BBB leakage in cSVD and aging. 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