@article{RN205,
   author = {Zhang, C. E. and Wong, S. M. and Uiterwijk, R. and Staals, J. and Backes, W. H. and Hoff, E. I. and Schreuder, T. and Jeukens, C. R. and Jansen, J. F. and van Oostenbrugge, R. J.},
   title = {Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition},
   journal = {Stroke},
   volume = {48},
   number = {3},
   pages = {658-663},
   note = {Zhang, C Eleana
Wong, Sau May
Uiterwijk, Renske
Staals, Julie
Backes, Walter H
Hoff, Erik I
Schreuder, Tobien
Jeukens, Cecile R L P N
Jansen, Jacobus F A
van Oostenbrugge, Robert J
eng
Research Support, Non-U.S. Gov't
2017/02/16 06:00
Stroke. 2017 Mar;48(3):658-663. doi: 10.1161/STROKEAHA.116.015084. Epub 2017 Feb 14.},
   abstract = {BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microstructural integrity in SVD patients, using intravoxel incoherent motion imaging-a diffusion-weighted magnetic resonance imaging technique designed to determine microvascular perfusion and microstructural integrity simultaneously. METHODS: Seventy-three patients with SVD and 39 controls underwent intravoxel incoherent motion imaging and neuropsychological assessment. Parenchymal diffusivity D (a surrogate measure of microstructural integrity) and perfusion-related measure fD* were calculated for the normal appearing white matter, white matter hyperintensities, and cortical gray matter. The associations between cognitive performance and D and fD* were determined. RESULTS: In SVD patients, multivariable analysis showed that lower fD* in the normal appearing white matter and cortical gray matter was associated with lower overall cognition (P=0.03 and P=0.002, respectively), lower executive function (P=0.04 and P=0.01, respectively), and lower information-processing speed (P=0.04 and P=0.01, respectively). D was not associated with cognitive function. In controls, no association was found between D, fD*, and cognition. CONCLUSIONS: In SVD patients, lower cognitive performance is associated with lower microvascular perfusion in the normal appearing white matter and cortical gray matter. Our results support recent findings that both cortical gray matter and normal appearing white matter perfusion may play a role in the pathophysiology of cognitive dysfunction in SVD. CLINICAL TRIAL REGISTRATION: URL: http://www.trialregister.nl. Unique identifier: NTR3786.},
   keywords = {Aged
Aged, 80 and over
Cerebral Small Vessel Diseases/*diagnostic imaging/physiopathology
Cognitive Dysfunction/*diagnostic imaging/physiopathology
Diffusion Magnetic Resonance Imaging/*methods
Female
Gray Matter/blood supply/*diagnostic imaging
Humans
Male
Microvessels/*diagnostic imaging
Middle Aged
White Matter/blood supply/*diagnostic imaging
*cerebral blood flow
*cerebral small vessel disease
*cognition},
   ISSN = {1524-4628 (Electronic)
0039-2499 (Linking)},
   DOI = {10.1161/STROKEAHA.116.015084},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/28196940},
   year = {2017},
   type = {Journal Article}
}

{"_id":"2T3atn4ZqPF5pirzL","bibbaseid":"zhang-wong-uiterwijk-staals-backes-hoff-schreuder-jeukens-etal-intravoxelincoherentmotionimaginginsmallvesseldiseasemicrostructuralintegrityandmicrovascularperfusionrelatedtocognition-2017","downloads":0,"creationDate":"2017-09-02T16:45:18.650Z","title":"Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition","author_short":["Zhang, C. E.","Wong, S. M.","Uiterwijk, R.","Staals, J.","Backes, W. H.","Hoff, E. I.","Schreuder, T.","Jeukens, C. R.","Jansen, J. F.","van Oostenbrugge, R. J."],"year":2017,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Zhang"],"firstnames":["C.","E."],"suffixes":[]},{"propositions":[],"lastnames":["Wong"],"firstnames":["S.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Uiterwijk"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Staals"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Hoff"],"firstnames":["E.","I."],"suffixes":[]},{"propositions":[],"lastnames":["Schreuder"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Jeukens"],"firstnames":["C.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":["van"],"lastnames":["Oostenbrugge"],"firstnames":["R.","J."],"suffixes":[]}],"title":"Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition","journal":"Stroke","volume":"48","number":"3","pages":"658-663","note":"Zhang, C Eleana Wong, Sau May Uiterwijk, Renske Staals, Julie Backes, Walter H Hoff, Erik I Schreuder, Tobien Jeukens, Cecile R L P N Jansen, Jacobus F A van Oostenbrugge, Robert J eng Research Support, Non-U.S. Gov't 2017/02/16 06:00 Stroke. 2017 Mar;48(3):658-663. doi: 10.1161/STROKEAHA.116.015084. Epub 2017 Feb 14.","abstract":"BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microstructural integrity in SVD patients, using intravoxel incoherent motion imaging-a diffusion-weighted magnetic resonance imaging technique designed to determine microvascular perfusion and microstructural integrity simultaneously. METHODS: Seventy-three patients with SVD and 39 controls underwent intravoxel incoherent motion imaging and neuropsychological assessment. Parenchymal diffusivity D (a surrogate measure of microstructural integrity) and perfusion-related measure fD* were calculated for the normal appearing white matter, white matter hyperintensities, and cortical gray matter. The associations between cognitive performance and D and fD* were determined. RESULTS: In SVD patients, multivariable analysis showed that lower fD* in the normal appearing white matter and cortical gray matter was associated with lower overall cognition (P=0.03 and P=0.002, respectively), lower executive function (P=0.04 and P=0.01, respectively), and lower information-processing speed (P=0.04 and P=0.01, respectively). D was not associated with cognitive function. In controls, no association was found between D, fD*, and cognition. CONCLUSIONS: In SVD patients, lower cognitive performance is associated with lower microvascular perfusion in the normal appearing white matter and cortical gray matter. Our results support recent findings that both cortical gray matter and normal appearing white matter perfusion may play a role in the pathophysiology of cognitive dysfunction in SVD. CLINICAL TRIAL REGISTRATION: URL: http://www.trialregister.nl. Unique identifier: NTR3786.","keywords":"Aged Aged, 80 and over Cerebral Small Vessel Diseases/*diagnostic imaging/physiopathology Cognitive Dysfunction/*diagnostic imaging/physiopathology Diffusion Magnetic Resonance Imaging/*methods Female Gray Matter/blood supply/*diagnostic imaging Humans Male Microvessels/*diagnostic imaging Middle Aged White Matter/blood supply/*diagnostic imaging *cerebral blood flow *cerebral small vessel disease *cognition","issn":"1524-4628 (Electronic) 0039-2499 (Linking)","doi":"10.1161/STROKEAHA.116.015084","url":"http://www.ncbi.nlm.nih.gov/pubmed/28196940","year":"2017","bibtex":"@article{RN205,\n author = {Zhang, C. E. and Wong, S. M. and Uiterwijk, R. and Staals, J. and Backes, W. H. and Hoff, E. I. and Schreuder, T. and Jeukens, C. R. and Jansen, J. F. and van Oostenbrugge, R. J.},\n title = {Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition},\n journal = {Stroke},\n volume = {48},\n number = {3},\n pages = {658-663},\n note = {Zhang, C Eleana\nWong, Sau May\nUiterwijk, Renske\nStaals, Julie\nBackes, Walter H\nHoff, Erik I\nSchreuder, Tobien\nJeukens, Cecile R L P N\nJansen, Jacobus F A\nvan Oostenbrugge, Robert J\neng\nResearch Support, Non-U.S. Gov't\n2017/02/16 06:00\nStroke. 2017 Mar;48(3):658-663. doi: 10.1161/STROKEAHA.116.015084. Epub 2017 Feb 14.},\n abstract = {BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microstructural integrity in SVD patients, using intravoxel incoherent motion imaging-a diffusion-weighted magnetic resonance imaging technique designed to determine microvascular perfusion and microstructural integrity simultaneously. METHODS: Seventy-three patients with SVD and 39 controls underwent intravoxel incoherent motion imaging and neuropsychological assessment. Parenchymal diffusivity D (a surrogate measure of microstructural integrity) and perfusion-related measure fD* were calculated for the normal appearing white matter, white matter hyperintensities, and cortical gray matter. The associations between cognitive performance and D and fD* were determined. RESULTS: In SVD patients, multivariable analysis showed that lower fD* in the normal appearing white matter and cortical gray matter was associated with lower overall cognition (P=0.03 and P=0.002, respectively), lower executive function (P=0.04 and P=0.01, respectively), and lower information-processing speed (P=0.04 and P=0.01, respectively). D was not associated with cognitive function. In controls, no association was found between D, fD*, and cognition. CONCLUSIONS: In SVD patients, lower cognitive performance is associated with lower microvascular perfusion in the normal appearing white matter and cortical gray matter. Our results support recent findings that both cortical gray matter and normal appearing white matter perfusion may play a role in the pathophysiology of cognitive dysfunction in SVD. CLINICAL TRIAL REGISTRATION: URL: http://www.trialregister.nl. 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