Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery

Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery. Zhang, Y., Wu, X., Vadlamani, R. A., Lim, Y., Kim, J., David, K., Gilbert, E., Li, Y., Wang, R., Jiang, S., Wang, A., Sontheimer, H., English, D., Emori, S., Davalos, R. V., Poelzing, S., & Jia, X. bioRxiv, 2023. Zhang, Yujing Wu, Xiaobo Vadlamani, Ram Anand Lim, Youngmin Kim, Jongwoon David, Kailee Gilbert, Earl Li, You Wang, Ruixuan Jiang, Shan Wang, Anbo Sontheimer, Harald English, Daniel Emori, Satoru Davalos, Rafael V Poelzing, Steven Jia, Xiaoting R01 NS123069/NS/NINDS NIH HHS/United States Preprint United States 2023/02/14 bioRxiv [Preprint]. 2023 Jan 30:2023.01.27.525973. doi: 10.1101/2023.01.27.525973.
doi abstract bibtex

Small-scale robots capable of remote active steering and navigation offer great potential for biomedical applications. However, the current design and manufacturing procedure impede their miniaturization and integration of various diagnostic and therapeutic functionalities. Here, we present a robotic fiber platform for integrating navigation, sensing, and therapeutic functions at a submillimeter scale. These fiber robots consist of ferromagnetic, electrical, optical, and microfluidic components, fabricated with a thermal drawing process. Under magnetic actuation, they can navigate through complex and constrained environments, such as artificial vessels and brain phantoms. Moreover, we utilize Langendorff mouse hearts model, glioblastoma microplatforms, and in vivo mouse models to demonstrate the capabilities of sensing electrophysiology signals and performing localized treatment. Additionally, we demonstrate that the fiber robots can serve as endoscopes with embedded waveguides. These fiber robots provide a versatile platform for targeted multimodal detection and treatment at hard-to-reach locations in a minimally invasive and remotely controllable manner.

@article{RN99,
author = {Zhang, Y. and Wu, X. and Vadlamani, R. A. and Lim, Y. and Kim, J. and David, K. and Gilbert, E. and Li, Y. and Wang, R. and Jiang, S. and Wang, A. and Sontheimer, H. and English, D. and Emori, S. and Davalos, R. V. and Poelzing, S. and Jia, X.},
title = {Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery},
journal = {bioRxiv},
note = {Zhang, Yujing
Wu, Xiaobo
Vadlamani, Ram Anand
Lim, Youngmin
Kim, Jongwoon
David, Kailee
Gilbert, Earl
Li, You
Wang, Ruixuan
Jiang, Shan
Wang, Anbo
Sontheimer, Harald
English, Daniel
Emori, Satoru
Davalos, Rafael V
Poelzing, Steven
Jia, Xiaoting
R01 NS123069/NS/NINDS NIH HHS/United States
Preprint
United States
2023/02/14
bioRxiv [Preprint]. 2023 Jan 30:2023.01.27.525973. doi: 10.1101/2023.01.27.525973.},
abstract = {Small-scale robots capable of remote active steering and navigation offer great potential for biomedical applications. However, the current design and manufacturing procedure impede their miniaturization and integration of various diagnostic and therapeutic functionalities. Here, we present a robotic fiber platform for integrating navigation, sensing, and therapeutic functions at a submillimeter scale. These fiber robots consist of ferromagnetic, electrical, optical, and microfluidic components, fabricated with a thermal drawing process. Under magnetic actuation, they can navigate through complex and constrained environments, such as artificial vessels and brain phantoms. Moreover, we utilize Langendorff mouse hearts model, glioblastoma microplatforms, and in vivo mouse models to demonstrate the capabilities of sensing electrophysiology signals and performing localized treatment. Additionally, we demonstrate that the fiber robots can serve as endoscopes with embedded waveguides. These fiber robots provide a versatile platform for targeted multimodal detection and treatment at hard-to-reach locations in a minimally invasive and remotely controllable manner.},
DOI = {10.1101/2023.01.27.525973},
year = {2023},
type = {Journal Article}
}

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V. and Poelzing, S. and Jia, X.},\n title = {Multifunctional ferromagnetic fiber robots for navigation, sensing, and treatment in minimally invasive surgery},\n journal = {bioRxiv},\n note = {Zhang, Yujing\nWu, Xiaobo\nVadlamani, Ram Anand\nLim, Youngmin\nKim, Jongwoon\nDavid, Kailee\nGilbert, Earl\nLi, You\nWang, Ruixuan\nJiang, Shan\nWang, Anbo\nSontheimer, Harald\nEnglish, Daniel\nEmori, Satoru\nDavalos, Rafael V\nPoelzing, Steven\nJia, Xiaoting\nR01 NS123069/NS/NINDS NIH HHS/United States\nPreprint\nUnited States\n2023/02/14\nbioRxiv [Preprint]. 2023 Jan 30:2023.01.27.525973. doi: 10.1101/2023.01.27.525973.},\n abstract = {Small-scale robots capable of remote active steering and navigation offer great potential for biomedical applications. However, the current design and manufacturing procedure impede their miniaturization and integration of various diagnostic and therapeutic functionalities. 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