@article{RN91,
   author = {Zhang, Y. and Wu, X. and Vadlamani, R. A. and Lim, Y. and Kim, J. and David, K. and Gilbert, E. and Li, Y. and Wang, R. and Jiang, S. and Wang, A. and Sontheimer, H. and English, D. F. and Emori, S. and Davalos, R. V. and Poelzing, S. and Jia, X.},
   title = {Submillimeter Multifunctional Ferromagnetic Fiber Robots for Navigation, Sensing, and Modulation},
   journal = {Adv Healthc Mater},
   volume = {12},
   number = {28},
   pages = {e2300964},
   note = {2192-2659
Zhang, Yujing
Wu, Xiaobo
Vadlamani, Ram Anand
Lim, Youngmin
Kim, Jongwoon
David, Kailee
Gilbert, Earl
Li, You
Wang, Ruixuan
Jiang, Shan
Wang, Anbo
Sontheimer, Harald
English, Daniel Fine
Emori, Satoru
Davalos, Rafael V
Poelzing, Steven
Jia, Xiaoting
Orcid: 0000-0003-4890-6103
R01 NS123069/NS/NINDS NIH HHS/United States
R21 EY033080/EY/NEI NIH HHS/United States
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Germany
2023/07/21
Adv Healthc Mater. 2023 Nov;12(28):e2300964. doi: 10.1002/adhm.202300964. Epub 2023 Jul 27.},
   abstract = {Small-scale robots capable of remote active steering and navigation offer great potential for biomedical applications. However, the current design and manufacturing procedure impede their miniaturization and integration of various diagnostic and therapeutic functionalities. Herein, submillimeter fiber robots that can integrate navigation, sensing, and modulation functions are presented. These fiber robots are fabricated through a scalable thermal drawing process at a speed of 4 meters per minute, which enables the integration of ferromagnetic, electrical, optical, and microfluidic composite with an overall diameter of as small as 250 µm and a length of as long as 150 m. The fiber tip deflection angle can reach up to 54(o) under a uniform magnetic field of 45 mT. These fiber robots can navigate through complex and constrained environments, such as artificial vessels and brain phantoms. Moreover, Langendorff mouse hearts model, glioblastoma micro platforms, and in vivo mouse models are utilized to demonstrate the capabilities of sensing electrophysiology signals and performing a localized treatment. Additionally, it is demonstrated that the fiber robots can serve as endoscopes with embedded waveguides. These fiber robots provide a versatile platform for targeted multimodal detection and treatment at hard-to-reach locations in a minimally invasive and remotely controllable manner.},
   keywords = {Animals
Mice
*Robotics/methods
Equipment Design
Miniaturization
Magnetic Fields
biomedical engineering
ferromagnetic robotics
fiber robots
micro robotics
thermal drawing},
   ISSN = {2192-2640 (Print)
2192-2640},
   DOI = {10.1002/adhm.202300964},
   year = {2023},
   type = {Journal Article}
}