Conformational conversion of DNA G-quadruplex induced by a cationic porphyrin. Zhang, H., Xiao, X., Wang, P., Pang, S., Qu, F., Ai, X., & Zhang, J. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(1):243–7, September, 2009. tex.ids= zhangConformationalConversionDNA2009 publisher: Elsevier B.V.![Conformational conversion of DNA G-quadruplex induced by a cationic porphyrin. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The interactions between cationic meso-tetrakis(4-(N-methylpyridiumyl))porphyrin (TMPyP4) and the G-quadruplex (G4) of human telomeric single-strand oligonucleotide d(TTAGGG)(2) (S12) have been investigated by means of circular dichroism (CD), UV-visible absorption and fluorescence spectroscopies. It is found that TMPyP4 can preferentially induce the conformational conversion of the G4 structure from the parallel type to the parallel/antiparallel mixture in the presence of K(+), and that it can directly induce the formation of antiparallel G4 structure from the single-strand oligonucleotide S12 in the absence of K(+). Furthermore, the comparable experiments of TMPyP4 with two single-strand oligonucleotides S6 d(TTAGGG) and S24 d(TAGGG(TTAGGG)(3)T) in the absence of K(+) show that TMPyP4 can also induce the formation of antiparallel G4 from S24 but not from S6, indicating that the end-loops of the G4 structure are the key factors for the formation of G4 induced by TMPyP4.
@article{Zhang2009,
title = {Conformational conversion of {DNA} {G}-quadruplex induced by a cationic porphyrin.},
volume = {74},
issn = {1873-3557},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19577954 http://www.sciencedirect.com/science/article/B6VNG-4WJ3F0B-9/2/94613944cc41c548a9d1baae6e32aa56},
doi = {10.1016/j.saa.2009.06.018},
abstract = {The interactions between cationic meso-tetrakis(4-(N-methylpyridiumyl))porphyrin (TMPyP4) and the G-quadruplex (G4) of human telomeric single-strand oligonucleotide d(TTAGGG)(2) (S12) have been investigated by means of circular dichroism (CD), UV-visible absorption and fluorescence spectroscopies. It is found that TMPyP4 can preferentially induce the conformational conversion of the G4 structure from the parallel type to the parallel/antiparallel mixture in the presence of K(+), and that it can directly induce the formation of antiparallel G4 structure from the single-strand oligonucleotide S12 in the absence of K(+). Furthermore, the comparable experiments of TMPyP4 with two single-strand oligonucleotides S6 d(TTAGGG) and S24 d(TAGGG(TTAGGG)(3)T) in the absence of K(+) show that TMPyP4 can also induce the formation of antiparallel G4 from S24 but not from S6, indicating that the end-loops of the G4 structure are the key factors for the formation of G4 induced by TMPyP4.},
number = {1},
journal = {Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy},
author = {Zhang, Huijuan and Xiao, Xiao and Wang, Peng and Pang, Siping and Qu, Feng and Ai, Xicheng and Zhang, Jianping},
month = sep,
year = {2009},
pmid = {19577954},
note = {tex.ids= zhangConformationalConversionDNA2009
publisher: Elsevier B.V.},
keywords = {Biological, Circular Dichroism, DNA, G-Quadruplexes, G-quadruplex (G4) TMPyP4 Conformational conversion, Humans, Models, Molecular Structure, Nucleic Acid Conformation, Nucleic Acid Conformation: drug effects, Porphyrins, Porphyrins: chemistry, Porphyrins: metabolism, Porphyrins: pharmacology, Potassium, Potassium: chemistry, Potassium: pharmacology, Single-Stranded, Single-Stranded: chemistry, Single-Stranded: drug effects, Single-Stranded: metabolism},
pages = {243--7},
}
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It is found that TMPyP4 can preferentially induce the conformational conversion of the G4 structure from the parallel type to the parallel/antiparallel mixture in the presence of K(+), and that it can directly induce the formation of antiparallel G4 structure from the single-strand oligonucleotide S12 in the absence of K(+). Furthermore, the comparable experiments of TMPyP4 with two single-strand oligonucleotides S6 d(TTAGGG) and S24 d(TAGGG(TTAGGG)(3)T) in the absence of K(+) show that TMPyP4 can also induce the formation of antiparallel G4 from S24 but not from S6, indicating that the end-loops of the G4 structure are the key factors for the formation of G4 induced by TMPyP4.","number":"1","journal":"Spectrochimica acta. 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