@article{
 title = {Long-range and local circuits for top-down modulation of visual cortex processing},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 pages = {660-665},
 volume = {345},
 websites = {http://www.sciencemag.org/content/345/6197/660.abstract},
 id = {c8ffba94-12a0-397f-95fa-0cb4db5353eb},
 created = {2015-03-20T23:35:47.000Z},
 file_attached = {false},
 profile_id = {ef1265e7-8a59-3f67-9e5d-46acc00ed701},
 group_id = {ac791549-4a16-3252-8de1-0fdef1a59e25},
 last_modified = {2015-03-20T23:35:47.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Zhang:2014km},
 source_type = {article},
 abstract = {Top-down modulation of sensory processing allows the animal to select inputs most relevant to current tasks. We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local γ-aminobutyric acid--ergic (GABAergic) circuits. Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation). Whereas somatostatin-positive GABAergic interneurons contributed preferentially to surround suppression, vasoactive intestinal peptide-positive interneurons were crucial for center facilitation. Long-range corticocortical projections thus act through local microcircuits to exert spatially specific top-down modulation of sensory processing.},
 bibtype = {article},
 author = {Zhang, Siyu and Xu, Min and Kamigaki, Tsukasa and Hoang Do, Johnny Phong and Chang, Wei-Cheng and Jenvay, Sean and Miyamichi, Kazunari and Luo, Liqun and Dan, Yang},
 journal = {Science},
 number = {6197}
}

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