@article{RN153,
   author = {Zhao, Y. and Liu, H. and Bhonsle, S. P. and Wang, Y. and Davalos, R. V. and Yao, C.},
   title = {Ablation outcome of irreversible electroporation on potato monitored by impedance spectrum under multi-electrode system},
   journal = {Biomed Eng Online},
   volume = {17},
   number = {1},
   pages = {126},
   note = {1475-925x
Zhao, Yajun
Orcid: 0000-0003-3029-0291
Liu, Hongmei
Bhonsle, Suyashree P
Wang, Yilin
Davalos, Rafael V
Yao, Chenguo
cstc2014jcyjjq90001/Natural Science Foundation Project of CQ CSTC/
CYB17011/Graduate Scientific Research and Innovation Foundation of Chongqing/
106112017CDJQJ158835/Fundamental Re-search Funds for the Central Universities/
PanCAN 16-65-IANN/the pancreatic cancer action network translational research Grant/
Journal Article
England
2018/09/22
Biomed Eng Online. 2018 Sep 20;17(1):126. doi: 10.1186/s12938-018-0562-9.},
   abstract = {BACKGROUND: Irreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to assessing treatment outcome. Analyzing changes in tissue impedance caused by electroporation has been proposed as a method for quantifying IRE ablation. In this paper, we assess the hypothesis that irreversible electroporation ablation outcome can be monitored using the impedance change measured by the electrode pairs not in use, getting more information about the ablation size in different directions. METHODS: Using a square four-electrode configuration, the two diagonal electrodes were used to electroporate potato tissue. Next, the impedance changes, before and after treatment, were measured from different electrode pairs and the impedance information was extracted by fitting the data to an equivalent circuit model. Finally, we correlated the change of impedance from various electrode pairs to the ablation geometry through the use of fitted functions; then these functions were used to predict the ablation size and compared to the numerical simulation results. RESULTS: The change in impedance from the electrodes used to apply pulses is larger and has higher deviation than the other electrode pairs. The ablation size and the change in resistance in the circuit model correlate with various linear functions. The coefficients of determination for the three functions are 0.8121, 0.8188 and 0.8691, respectively, showing satisfactory agreement. The functions can well predict the ablation size under different pulse numbers, and in some directions it did even better than the numerical simulation method, which used different electric field thresholds for different pulse numbers. CONCLUSIONS: The relative change in tissue impedance measured from the non-energized electrodes can be used to assess ablation size during treatment with IRE according to linear functions.},
   keywords = {Ablation Techniques/*instrumentation
Electric Impedance
Electrodes
Electroporation/*instrumentation
Equipment Design
Solanum tuberosum/*cytology
Ablation size
Bioimpedance
Electroporation assessment
Equivalent circuit model
Irreversible electroporation
Tumor therapy},
   ISSN = {1475-925x},
   DOI = {10.1186/s12938-018-0562-9},
   year = {2018},
   type = {Journal Article}
}

{"_id":"S84AhmjpdBARzyqYC","bibbaseid":"zhao-liu-bhonsle-wang-davalos-yao-ablationoutcomeofirreversibleelectroporationonpotatomonitoredbyimpedancespectrumundermultielectrodesystem-2018","author_short":["Zhao, Y.","Liu, H.","Bhonsle, S. P.","Wang, Y.","Davalos, R. V.","Yao, C."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Zhao"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Liu"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Bhonsle"],"firstnames":["S.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]},{"propositions":[],"lastnames":["Yao"],"firstnames":["C."],"suffixes":[]}],"title":"Ablation outcome of irreversible electroporation on potato monitored by impedance spectrum under multi-electrode system","journal":"Biomed Eng Online","volume":"17","number":"1","pages":"126","note":"1475-925x Zhao, Yajun Orcid: 0000-0003-3029-0291 Liu, Hongmei Bhonsle, Suyashree P Wang, Yilin Davalos, Rafael V Yao, Chenguo cstc2014jcyjjq90001/Natural Science Foundation Project of CQ CSTC/ CYB17011/Graduate Scientific Research and Innovation Foundation of Chongqing/ 106112017CDJQJ158835/Fundamental Re-search Funds for the Central Universities/ PanCAN 16-65-IANN/the pancreatic cancer action network translational research Grant/ Journal Article England 2018/09/22 Biomed Eng Online. 2018 Sep 20;17(1):126. doi: 10.1186/s12938-018-0562-9.","abstract":"BACKGROUND: Irreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to assessing treatment outcome. Analyzing changes in tissue impedance caused by electroporation has been proposed as a method for quantifying IRE ablation. In this paper, we assess the hypothesis that irreversible electroporation ablation outcome can be monitored using the impedance change measured by the electrode pairs not in use, getting more information about the ablation size in different directions. METHODS: Using a square four-electrode configuration, the two diagonal electrodes were used to electroporate potato tissue. Next, the impedance changes, before and after treatment, were measured from different electrode pairs and the impedance information was extracted by fitting the data to an equivalent circuit model. Finally, we correlated the change of impedance from various electrode pairs to the ablation geometry through the use of fitted functions; then these functions were used to predict the ablation size and compared to the numerical simulation results. RESULTS: The change in impedance from the electrodes used to apply pulses is larger and has higher deviation than the other electrode pairs. The ablation size and the change in resistance in the circuit model correlate with various linear functions. The coefficients of determination for the three functions are 0.8121, 0.8188 and 0.8691, respectively, showing satisfactory agreement. The functions can well predict the ablation size under different pulse numbers, and in some directions it did even better than the numerical simulation method, which used different electric field thresholds for different pulse numbers. CONCLUSIONS: The relative change in tissue impedance measured from the non-energized electrodes can be used to assess ablation size during treatment with IRE according to linear functions.","keywords":"Ablation Techniques/*instrumentation Electric Impedance Electrodes Electroporation/*instrumentation Equipment Design Solanum tuberosum/*cytology Ablation size Bioimpedance Electroporation assessment Equivalent circuit model Irreversible electroporation Tumor therapy","issn":"1475-925x","doi":"10.1186/s12938-018-0562-9","year":"2018","bibtex":"@article{RN153,\n author = {Zhao, Y. and Liu, H. and Bhonsle, S. P. and Wang, Y. and Davalos, R. V. and Yao, C.},\n title = {Ablation outcome of irreversible electroporation on potato monitored by impedance spectrum under multi-electrode system},\n journal = {Biomed Eng Online},\n volume = {17},\n number = {1},\n pages = {126},\n note = {1475-925x\nZhao, Yajun\nOrcid: 0000-0003-3029-0291\nLiu, Hongmei\nBhonsle, Suyashree P\nWang, Yilin\nDavalos, Rafael V\nYao, Chenguo\ncstc2014jcyjjq90001/Natural Science Foundation Project of CQ CSTC/\nCYB17011/Graduate Scientific Research and Innovation Foundation of Chongqing/\n106112017CDJQJ158835/Fundamental Re-search Funds for the Central Universities/\nPanCAN 16-65-IANN/the pancreatic cancer action network translational research Grant/\nJournal Article\nEngland\n2018/09/22\nBiomed Eng Online. 2018 Sep 20;17(1):126. doi: 10.1186/s12938-018-0562-9.},\n abstract = {BACKGROUND: Irreversible electroporation (IRE) therapy relies on pulsed electric fields to non-thermally ablate cancerous tissue. Methods for evaluating IRE ablation in situ are critical to assessing treatment outcome. Analyzing changes in tissue impedance caused by electroporation has been proposed as a method for quantifying IRE ablation. In this paper, we assess the hypothesis that irreversible electroporation ablation outcome can be monitored using the impedance change measured by the electrode pairs not in use, getting more information about the ablation size in different directions. METHODS: Using a square four-electrode configuration, the two diagonal electrodes were used to electroporate potato tissue. Next, the impedance changes, before and after treatment, were measured from different electrode pairs and the impedance information was extracted by fitting the data to an equivalent circuit model. Finally, we correlated the change of impedance from various electrode pairs to the ablation geometry through the use of fitted functions; then these functions were used to predict the ablation size and compared to the numerical simulation results. RESULTS: The change in impedance from the electrodes used to apply pulses is larger and has higher deviation than the other electrode pairs. The ablation size and the change in resistance in the circuit model correlate with various linear functions. The coefficients of determination for the three functions are 0.8121, 0.8188 and 0.8691, respectively, showing satisfactory agreement. The functions can well predict the ablation size under different pulse numbers, and in some directions it did even better than the numerical simulation method, which used different electric field thresholds for different pulse numbers. CONCLUSIONS: The relative change in tissue impedance measured from the non-energized electrodes can be used to assess ablation size during treatment with IRE according to linear functions.},\n keywords = {Ablation Techniques/*instrumentation\nElectric Impedance\nElectrodes\nElectroporation/*instrumentation\nEquipment Design\nSolanum tuberosum/*cytology\nAblation size\nBioimpedance\nElectroporation assessment\nEquivalent circuit model\nIrreversible electroporation\nTumor therapy},\n ISSN = {1475-925x},\n DOI = {10.1186/s12938-018-0562-9},\n year = {2018},\n type = {Journal Article}\n}\n\n","author_short":["Zhao, Y.","Liu, H.","Bhonsle, S. P.","Wang, Y.","Davalos, R. V.","Yao, C."],"key":"RN153","id":"RN153","bibbaseid":"zhao-liu-bhonsle-wang-davalos-yao-ablationoutcomeofirreversibleelectroporationonpotatomonitoredbyimpedancespectrumundermultielectrodesystem-2018","role":"author","urls":{},"keyword":["Ablation Techniques/*instrumentation Electric Impedance Electrodes Electroporation/*instrumentation Equipment Design Solanum tuberosum/*cytology Ablation size Bioimpedance Electroporation assessment Equivalent circuit model Irreversible electroporation Tumor therapy"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["ablation techniques/*instrumentation electric impedance electrodes electroporation/*instrumentation equipment design solanum tuberosum/*cytology ablation size bioimpedance electroporation assessment equivalent circuit model irreversible electroporation tumor therapy"],"search_terms":["ablation","outcome","irreversible","electroporation","potato","monitored","impedance","spectrum","under","multi","electrode","system","zhao","liu","bhonsle","wang","davalos","yao"],"title":"Ablation outcome of irreversible electroporation on potato monitored by impedance spectrum under multi-electrode system","year":2018}