@article{RN108,
   author = {Zhao, Y. and McKillop, I. H. and Davalos, R. V.},
   title = {Modeling of a single bipolar electrode with tines for irreversible electroporation delivery},
   journal = {Comput Biol Med},
   volume = {142},
   pages = {104870},
   note = {1879-0534
Zhao, Yajun
McKillop, Iain H
Davalos, Rafael V
R01 CA240476/CA/NCI NIH HHS/United States
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
United States
2022/01/21
Comput Biol Med. 2022 Mar;142:104870. doi: 10.1016/j.compbiomed.2021.104870. Epub 2021 Sep 14.},
   abstract = {Irreversible electroporation (IRE) is a non-thermal tumor ablation technology employed to treat solid tumors not amenable to resection or thermal ablation. The IRE systems currently in clinical use deliver electrical pulses via multiple monopolar electrodes. This approach can present significant technical challenges due to the requirement for accurate placement of multiple electrodes and maintenance of parallel electrode alignment during pulse delivery. In this study, we sought to evaluate a novel IRE electrode configuration consisting of a single bipolar electrode with deployable tines. Using commercial finite element software predicted ablation outcomes, thermal damage, ablation sphericity, and energy delivery were calculated for existing monopolar and bipolar electrodes, and bipolar electrodes with either 4 or 8 deployable tines. The bipolar electrodes with tines generated larger predicted ablations compared to existing monopolar (>100%) and bipolar (>10%) arrangements, and the ablation shape using bipolar electrodes with tines were more spherical than those modeled for bipolar electrodes. Thermal damage modeled for bipolar electrodes and bipolar electrodes with tines was less than that of monopolar electrodes (using identical pulse parameters), and bipolar electrodes with tines delivered less energy than monopolar or bipolar electrodes. These studies using a single point of device insertion suggest the potential for developing alternative IRE delivery techniques, and may simplify clinical use and increase the predicted ablation shape/volume.},
   keywords = {Electrodes
*Electroporation/methods
Irreversible electroporation (IRE)
Non-thermal ablation
Single needle insertion
Spherical ablation},
   ISSN = {0010-4825 (Print)
0010-4825},
   DOI = {10.1016/j.compbiomed.2021.104870},
   year = {2022},
   type = {Journal Article}
}

{"_id":"m8gLtxS93fdsEMPpy","bibbaseid":"zhao-mckillop-davalos-modelingofasinglebipolarelectrodewithtinesforirreversibleelectroporationdelivery-2022","author_short":["Zhao, Y.","McKillop, I. H.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Zhao"],"firstnames":["Y."],"suffixes":[]},{"propositions":[],"lastnames":["McKillop"],"firstnames":["I.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Modeling of a single bipolar electrode with tines for irreversible electroporation delivery","journal":"Comput Biol Med","volume":"142","pages":"104870","note":"1879-0534 Zhao, Yajun McKillop, Iain H Davalos, Rafael V R01 CA240476/CA/NCI NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States 2022/01/21 Comput Biol Med. 2022 Mar;142:104870. doi: 10.1016/j.compbiomed.2021.104870. Epub 2021 Sep 14.","abstract":"Irreversible electroporation (IRE) is a non-thermal tumor ablation technology employed to treat solid tumors not amenable to resection or thermal ablation. The IRE systems currently in clinical use deliver electrical pulses via multiple monopolar electrodes. This approach can present significant technical challenges due to the requirement for accurate placement of multiple electrodes and maintenance of parallel electrode alignment during pulse delivery. In this study, we sought to evaluate a novel IRE electrode configuration consisting of a single bipolar electrode with deployable tines. Using commercial finite element software predicted ablation outcomes, thermal damage, ablation sphericity, and energy delivery were calculated for existing monopolar and bipolar electrodes, and bipolar electrodes with either 4 or 8 deployable tines. The bipolar electrodes with tines generated larger predicted ablations compared to existing monopolar (>100%) and bipolar (>10%) arrangements, and the ablation shape using bipolar electrodes with tines were more spherical than those modeled for bipolar electrodes. Thermal damage modeled for bipolar electrodes and bipolar electrodes with tines was less than that of monopolar electrodes (using identical pulse parameters), and bipolar electrodes with tines delivered less energy than monopolar or bipolar electrodes. These studies using a single point of device insertion suggest the potential for developing alternative IRE delivery techniques, and may simplify clinical use and increase the predicted ablation shape/volume.","keywords":"Electrodes *Electroporation/methods Irreversible electroporation (IRE) Non-thermal ablation Single needle insertion Spherical ablation","issn":"0010-4825 (Print) 0010-4825","doi":"10.1016/j.compbiomed.2021.104870","year":"2022","bibtex":"@article{RN108,\n author = {Zhao, Y. and McKillop, I. H. and Davalos, R. V.},\n title = {Modeling of a single bipolar electrode with tines for irreversible electroporation delivery},\n journal = {Comput Biol Med},\n volume = {142},\n pages = {104870},\n note = {1879-0534\nZhao, Yajun\nMcKillop, Iain H\nDavalos, Rafael V\nR01 CA240476/CA/NCI NIH HHS/United States\nJournal Article\nResearch Support, N.I.H., Extramural\nResearch Support, Non-U.S. Gov't\nUnited States\n2022/01/21\nComput Biol Med. 2022 Mar;142:104870. doi: 10.1016/j.compbiomed.2021.104870. Epub 2021 Sep 14.},\n abstract = {Irreversible electroporation (IRE) is a non-thermal tumor ablation technology employed to treat solid tumors not amenable to resection or thermal ablation. The IRE systems currently in clinical use deliver electrical pulses via multiple monopolar electrodes. This approach can present significant technical challenges due to the requirement for accurate placement of multiple electrodes and maintenance of parallel electrode alignment during pulse delivery. In this study, we sought to evaluate a novel IRE electrode configuration consisting of a single bipolar electrode with deployable tines. Using commercial finite element software predicted ablation outcomes, thermal damage, ablation sphericity, and energy delivery were calculated for existing monopolar and bipolar electrodes, and bipolar electrodes with either 4 or 8 deployable tines. The bipolar electrodes with tines generated larger predicted ablations compared to existing monopolar (>100%) and bipolar (>10%) arrangements, and the ablation shape using bipolar electrodes with tines were more spherical than those modeled for bipolar electrodes. Thermal damage modeled for bipolar electrodes and bipolar electrodes with tines was less than that of monopolar electrodes (using identical pulse parameters), and bipolar electrodes with tines delivered less energy than monopolar or bipolar electrodes. These studies using a single point of device insertion suggest the potential for developing alternative IRE delivery techniques, and may simplify clinical use and increase the predicted ablation shape/volume.},\n keywords = {Electrodes\n*Electroporation/methods\nIrreversible electroporation (IRE)\nNon-thermal ablation\nSingle needle insertion\nSpherical ablation},\n ISSN = {0010-4825 (Print)\n0010-4825},\n DOI = {10.1016/j.compbiomed.2021.104870},\n year = {2022},\n type = {Journal Article}\n}\n\n","author_short":["Zhao, Y.","McKillop, I. H.","Davalos, R. 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