@article{RN6181,
   author = {Zheng, S. and Chheda, M. G. and Verhaak, R. G.},
   title = {Studying a complex tumor: potential and pitfalls},
   journal = {Cancer J},
   volume = {18},
   number = {1},
   pages = {107-14},
   note = {1540-336x
Zheng, Siyuan
Chheda, Milan G
Verhaak, Roel G W
K08 NS062907/NS/NINDS NIH HHS/United States
U24 CA143883/CA/NCI NIH HHS/United States
U24 CA143883-01/CA/NCI NIH HHS/United States
U24CA143883/CA/NCI NIH HHS/United States
5K08NS062907/NS/NINDS NIH HHS/United States
Journal Article
Research Support, N.I.H., Extramural
Review
United States
2012/02/01
Cancer J. 2012 Jan-Feb;18(1):107-14. doi: 10.1097/PPO.0b013e3182431c57.},
   abstract = {Glioblastoma multiforme is a histopathologically heterogeneous disease with few treatment options. Therapy based on genomic alterations is rapidly gaining popularity because of the high response rate and high specificity. DNA copy number and exon-sequencing studies of glioblastoma multiforme samples have revealed recurrent genomic alterations in genes such as TP53, EGFR, and IDH1, but to date, this has not resulted in novel glioblastoma multiforme therapies. Identification of expression subtypes has resulted in new insights such as the association between genomic abnormalities and expression signatures. This review describes the types of genomic studies that have been performed and that are underway, the most prominent results, and the implications of genomic research for the development of clinical treatment modalities.},
   keywords = {Brain Neoplasms/*genetics/pathology/*therapy
Gene Expression Profiling
Genetic Therapy/*methods
Genomics/*methods
Glioblastoma/*genetics/pathology/*therapy
Humans},
   ISSN = {1528-9117 (Print)
1528-9117},
   DOI = {10.1097/PPO.0b013e3182431c57},
   year = {2012},
   type = {Journal Article}
}

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G."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Zheng"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Chheda"],"firstnames":["M.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Verhaak"],"firstnames":["R.","G."],"suffixes":[]}],"title":"Studying a complex tumor: potential and pitfalls","journal":"Cancer J","volume":"18","number":"1","pages":"107-14","note":"1540-336x Zheng, Siyuan Chheda, Milan G Verhaak, Roel G W K08 NS062907/NS/NINDS NIH HHS/United States U24 CA143883/CA/NCI NIH HHS/United States U24 CA143883-01/CA/NCI NIH HHS/United States U24CA143883/CA/NCI NIH HHS/United States 5K08NS062907/NS/NINDS NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Review United States 2012/02/01 Cancer J. 2012 Jan-Feb;18(1):107-14. doi: 10.1097/PPO.0b013e3182431c57.","abstract":"Glioblastoma multiforme is a histopathologically heterogeneous disease with few treatment options. 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G.},\n title = {Studying a complex tumor: potential and pitfalls},\n journal = {Cancer J},\n volume = {18},\n number = {1},\n pages = {107-14},\n note = {1540-336x\nZheng, Siyuan\nChheda, Milan G\nVerhaak, Roel G W\nK08 NS062907/NS/NINDS NIH HHS/United States\nU24 CA143883/CA/NCI NIH HHS/United States\nU24 CA143883-01/CA/NCI NIH HHS/United States\nU24CA143883/CA/NCI NIH HHS/United States\n5K08NS062907/NS/NINDS NIH HHS/United States\nJournal Article\nResearch Support, N.I.H., Extramural\nReview\nUnited States\n2012/02/01\nCancer J. 2012 Jan-Feb;18(1):107-14. doi: 10.1097/PPO.0b013e3182431c57.},\n abstract = {Glioblastoma multiforme is a histopathologically heterogeneous disease with few treatment options. Therapy based on genomic alterations is rapidly gaining popularity because of the high response rate and high specificity. 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