@article{zheng_model_2002,
	title = {A model of the hemodynamic response and oxygen delivery to brain},
	volume = {16},
	issn = {1053-8119},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/12169248},
	abstract = {A recent nonlinear system by Friston et al. (2000. NeuroImage 12: 466-477) links the changes in BOLD response to changes in neural activity. The system consists of five subsystems, linking: (1) neural activity to flow changes; (2) flow changes to oxygen delivery to tissue; (3) flow changes to changes in blood volume and venous outflow; (4) changes in flow, volume, and oxygen extraction fraction to deoxyhemoglobin changes; and finally (5) volume and deoxyhemoglobin changes to the BOLD response. Friston et al. exploit, in subsystem 2, a model by Buxton and Frank coupling flow changes to changes in oxygen metabolism which assumes tissue oxygen concentration to be close to zero. We describe below a model of the coupling between flow and oxygen delivery which takes into account the modulatory effect of changes in tissue oxygen concentration. The major development has been to extend the original Buxton and Frank model for oxygen transport to a full dynamic capillary model making the model applicable to both transient and steady state conditions. Furthermore our modification enables us to determine the time series of CMRO(2) changes under different conditions, including CO(2) challenges. We compare the differences in the performance of the "Friston system" using the original model of Buxton and Frank and that of our model. We also compare the data predicted by our model (with appropriate parameters) to data from a series of OIS studies. The qualitative differences in the behaviour of the models are exposed by different experimental simulations and by comparison with the results of OIS data from brief and extended stimulation protocols and from experiments using hypercapnia.},
	number = {3 Pt 1},
	urldate = {2009-05-18},
	journal = {NeuroImage},
	author = {Zheng, Ying and Martindale, John and Johnston, David and Jones, Myles and Berwick, Jason and Mayhew, John},
	month = jul,
	year = {2002},
	pmid = {12169248},
	keywords = {theory, BOLD, balloonmodel, metabolism},
	pages = {617--637},
	file = {PubMed Snapshot:/Users/nickb/Zotero/storage/KEMTVJDD/entrez.html:text/html;zheng2002.pdf:/Users/nickb/Zotero/storage/HQN46CS5/zheng2002.pdf:application/pdf}
}

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The system consists of five subsystems, linking: (1) neural activity to flow changes; (2) flow changes to oxygen delivery to tissue; (3) flow changes to changes in blood volume and venous outflow; (4) changes in flow, volume, and oxygen extraction fraction to deoxyhemoglobin changes; and finally (5) volume and deoxyhemoglobin changes to the BOLD response. Friston et al. exploit, in subsystem 2, a model by Buxton and Frank coupling flow changes to changes in oxygen metabolism which assumes tissue oxygen concentration to be close to zero. We describe below a model of the coupling between flow and oxygen delivery which takes into account the modulatory effect of changes in tissue oxygen concentration. The major development has been to extend the original Buxton and Frank model for oxygen transport to a full dynamic capillary model making the model applicable to both transient and steady state conditions. Furthermore our modification enables us to determine the time series of CMRO(2) changes under different conditions, including CO(2) challenges. We compare the differences in the performance of the \"Friston system\" using the original model of Buxton and Frank and that of our model. We also compare the data predicted by our model (with appropriate parameters) to data from a series of OIS studies. 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