@article{zhou_risk_2014,
	title = {Risk of acute myocardial infarction, stroke, or death in patients initiating olmesartan or other angiotensin receptor blockers - a cohort study using the {Clinical} {Practice} {Research} {Datalink}},
	volume = {23},
	issn = {1099-1557},
	doi = {10.1002/pds.3549},
	abstract = {PURPOSE: Results of two randomized trials (ROADMAP and ORIENT) suggest that high-dose (40 mg/day) olmesartan (Olm) is associated with increased cardiovascular mortality compared to placebo in diabetic patients. We evaluated the risks of acute myocardial infarction (AMI) and death in patients initiating Olm compared with an active comparator group, other angiotensin receptor blockers (ARBs), with a focus on high-dose and diabetic subgroups.
METHODS: We conducted a cohort study with patients who initiated Olm or another ARB between 2003 and 2011, using the UK Clinical Practice Research Datalink GOLD. We included patients who had no prior ARB or angiotensin converting enzyme inhibitor exposure during the preceding 6 months. Hazard ratios (HRs) were estimated using Cox regression models with both multivariable adjustment and propensity score matching.
RESULTS: There were 3964 Olm and 54 653 other-ARB initiators, respectively. Adjusted HRs comparing Olm and other-ARBs were 1.04 (95\% CI: 0.75-1.42) for AMI and 1.16 (0.95-1.42) for death, using multivariable adjustment. Comparing patients initiated with a high-dose Olm and a high-dose other-ARB, HRs were 3.09 (0.94-10.13) for AMI and 2.03 (0.74-5.61) for death, using multivariable adjustment; and 4.38 (0.97-19.66) and 1.99 (0.63-6.32) for AMI and death, using propensity score matching.
CONCLUSIONS: Overall, no differences in risk were observed in the main cohort analyses comparing Olm initiators with patients initiating therapy with other ARBs; however, HRs were marginally increased for all study endpoints which compared high-dose subgroups, suggesting potential increased risk may be associated with high-dose Olm. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.},
	language = {eng},
	number = {4},
	journal = {Pharmacoepidemiology and Drug Safety},
	author = {Zhou, Esther H. and Gelperin, Kate and Levenson, Mark S. and Rose, Martin and Hsueh, Ya-Hui and Graham, David J.},
	month = apr,
	year = {2014},
	pmid = {24285502},
	keywords = {Adult, Aged, Aged, 80 and over, Angiotensin Receptor Antagonists, Cohort Studies, Databases, Factual, Death, Dose-Response Relationship, Drug, Female, Humans, Imidazoles, Male, Middle Aged, Myocardial Infarction, Proportional Hazards Models, Regression Analysis, Risk, Tetrazoles, acute myocardial infarction (AMI), angiotensin receptor blockers (ARBs), diabetes mellitus, olmesartan, pharmacoepidemiology, stroke},
	pages = {340--347}
}

{"_id":"5o6CwJz835g4MGrku","bibbaseid":"zhou-gelperin-levenson-rose-hsueh-graham-riskofacutemyocardialinfarctionstrokeordeathinpatientsinitiatingolmesartanorotherangiotensinreceptorblockersacohortstudyusingtheclinicalpracticeresearchdatalink-2014","downloads":0,"creationDate":"2017-08-15T09:38:10.273Z","title":"Risk of acute myocardial infarction, stroke, or death in patients initiating olmesartan or other angiotensin receptor blockers - a cohort study using the Clinical Practice Research Datalink","author_short":["Zhou, E. H.","Gelperin, K.","Levenson, M. S.","Rose, M.","Hsueh, Y.","Graham, D. J."],"year":2014,"bibtype":"article","biburl":"http://bibbase.org/zotero/veegee78","bibdata":{"bibtype":"article","type":"article","title":"Risk of acute myocardial infarction, stroke, or death in patients initiating olmesartan or other angiotensin receptor blockers - a cohort study using the Clinical Practice Research Datalink","volume":"23","issn":"1099-1557","doi":"10.1002/pds.3549","abstract":"PURPOSE: Results of two randomized trials (ROADMAP and ORIENT) suggest that high-dose (40 mg/day) olmesartan (Olm) is associated with increased cardiovascular mortality compared to placebo in diabetic patients. We evaluated the risks of acute myocardial infarction (AMI) and death in patients initiating Olm compared with an active comparator group, other angiotensin receptor blockers (ARBs), with a focus on high-dose and diabetic subgroups. METHODS: We conducted a cohort study with patients who initiated Olm or another ARB between 2003 and 2011, using the UK Clinical Practice Research Datalink GOLD. We included patients who had no prior ARB or angiotensin converting enzyme inhibitor exposure during the preceding 6 months. Hazard ratios (HRs) were estimated using Cox regression models with both multivariable adjustment and propensity score matching. RESULTS: There were 3964 Olm and 54 653 other-ARB initiators, respectively. Adjusted HRs comparing Olm and other-ARBs were 1.04 (95% CI: 0.75-1.42) for AMI and 1.16 (0.95-1.42) for death, using multivariable adjustment. Comparing patients initiated with a high-dose Olm and a high-dose other-ARB, HRs were 3.09 (0.94-10.13) for AMI and 2.03 (0.74-5.61) for death, using multivariable adjustment; and 4.38 (0.97-19.66) and 1.99 (0.63-6.32) for AMI and death, using propensity score matching. CONCLUSIONS: Overall, no differences in risk were observed in the main cohort analyses comparing Olm initiators with patients initiating therapy with other ARBs; however, HRs were marginally increased for all study endpoints which compared high-dose subgroups, suggesting potential increased risk may be associated with high-dose Olm. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.","language":"eng","number":"4","journal":"Pharmacoepidemiology and Drug Safety","author":[{"propositions":[],"lastnames":["Zhou"],"firstnames":["Esther","H."],"suffixes":[]},{"propositions":[],"lastnames":["Gelperin"],"firstnames":["Kate"],"suffixes":[]},{"propositions":[],"lastnames":["Levenson"],"firstnames":["Mark","S."],"suffixes":[]},{"propositions":[],"lastnames":["Rose"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Hsueh"],"firstnames":["Ya-Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Graham"],"firstnames":["David","J."],"suffixes":[]}],"month":"April","year":"2014","pmid":"24285502","keywords":"Adult, Aged, Aged, 80 and over, Angiotensin Receptor Antagonists, Cohort Studies, Databases, Factual, Death, Dose-Response Relationship, Drug, Female, Humans, Imidazoles, Male, Middle Aged, Myocardial Infarction, Proportional Hazards Models, Regression Analysis, Risk, Tetrazoles, acute myocardial infarction (AMI), angiotensin receptor blockers (ARBs), diabetes mellitus, olmesartan, pharmacoepidemiology, stroke","pages":"340--347","bibtex":"@article{zhou_risk_2014,\n\ttitle = {Risk of acute myocardial infarction, stroke, or death in patients initiating olmesartan or other angiotensin receptor blockers - a cohort study using the {Clinical} {Practice} {Research} {Datalink}},\n\tvolume = {23},\n\tissn = {1099-1557},\n\tdoi = {10.1002/pds.3549},\n\tabstract = {PURPOSE: Results of two randomized trials (ROADMAP and ORIENT) suggest that high-dose (40 mg/day) olmesartan (Olm) is associated with increased cardiovascular mortality compared to placebo in diabetic patients. We evaluated the risks of acute myocardial infarction (AMI) and death in patients initiating Olm compared with an active comparator group, other angiotensin receptor blockers (ARBs), with a focus on high-dose and diabetic subgroups.\nMETHODS: We conducted a cohort study with patients who initiated Olm or another ARB between 2003 and 2011, using the UK Clinical Practice Research Datalink GOLD. We included patients who had no prior ARB or angiotensin converting enzyme inhibitor exposure during the preceding 6 months. Hazard ratios (HRs) were estimated using Cox regression models with both multivariable adjustment and propensity score matching.\nRESULTS: There were 3964 Olm and 54 653 other-ARB initiators, respectively. Adjusted HRs comparing Olm and other-ARBs were 1.04 (95\\% CI: 0.75-1.42) for AMI and 1.16 (0.95-1.42) for death, using multivariable adjustment. Comparing patients initiated with a high-dose Olm and a high-dose other-ARB, HRs were 3.09 (0.94-10.13) for AMI and 2.03 (0.74-5.61) for death, using multivariable adjustment; and 4.38 (0.97-19.66) and 1.99 (0.63-6.32) for AMI and death, using propensity score matching.\nCONCLUSIONS: Overall, no differences in risk were observed in the main cohort analyses comparing Olm initiators with patients initiating therapy with other ARBs; however, HRs were marginally increased for all study endpoints which compared high-dose subgroups, suggesting potential increased risk may be associated with high-dose Olm. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Pharmacoepidemiology and Drug Safety},\n\tauthor = {Zhou, Esther H. and Gelperin, Kate and Levenson, Mark S. and Rose, Martin and Hsueh, Ya-Hui and Graham, David J.},\n\tmonth = apr,\n\tyear = {2014},\n\tpmid = {24285502},\n\tkeywords = {Adult, Aged, Aged, 80 and over, Angiotensin Receptor Antagonists, Cohort Studies, Databases, Factual, Death, Dose-Response Relationship, Drug, Female, Humans, Imidazoles, Male, Middle Aged, Myocardial Infarction, Proportional Hazards Models, Regression Analysis, Risk, Tetrazoles, acute myocardial infarction (AMI), angiotensin receptor blockers (ARBs), diabetes mellitus, olmesartan, pharmacoepidemiology, stroke},\n\tpages = {340--347}\n}\n\n","author_short":["Zhou, E. H.","Gelperin, K.","Levenson, M. S.","Rose, M.","Hsueh, Y.","Graham, D. J."],"key":"zhou_risk_2014","id":"zhou_risk_2014","bibbaseid":"zhou-gelperin-levenson-rose-hsueh-graham-riskofacutemyocardialinfarctionstrokeordeathinpatientsinitiatingolmesartanorotherangiotensinreceptorblockersacohortstudyusingtheclinicalpracticeresearchdatalink-2014","role":"author","urls":{},"keyword":["Adult","Aged","Aged","80 and over","Angiotensin Receptor Antagonists","Cohort Studies","Databases","Factual","Death","Dose-Response Relationship","Drug","Female","Humans","Imidazoles","Male","Middle Aged","Myocardial Infarction","Proportional Hazards Models","Regression Analysis","Risk","Tetrazoles","acute myocardial infarction (AMI)","angiotensin receptor blockers (ARBs)","diabetes mellitus","olmesartan","pharmacoepidemiology","stroke"],"downloads":0},"search_terms":["risk","acute","myocardial","infarction","stroke","death","patients","initiating","olmesartan","angiotensin","receptor","blockers","cohort","study","using","clinical","practice","research","datalink","zhou","gelperin","levenson","rose","hsueh","graham"],"keywords":["adult","aged","aged","80 and over","angiotensin receptor antagonists","cohort studies","databases","factual","death","dose-response relationship","drug","female","humans","imidazoles","male","middle aged","myocardial infarction","proportional hazards models","regression analysis","risk","tetrazoles","acute myocardial infarction (ami)","angiotensin receptor blockers (arbs)","diabetes mellitus","olmesartan","pharmacoepidemiology","stroke"],"authorIDs":[],"dataSources":["FmCWXwJibZiWNzpdc"]}