Activation of the prefrontal cortex during judgments of recency: a functional MRI study. Zorrilla, L. T., Aguirre, G. K., Zarahn, E., Cannon, T. D., & D'Esposito, M. Neuroreport, 7(15-17):2803-6, 1996.
abstract   bibtex   
Animal and human lesion studies have consistently shown that damage to the prefrontal lobe disrupts performance on tasks requiring memory for temporal context. In this study, functional magnetic resonance imaging (fMRI) was used to explore the brain regions associated with judgements of relative recency in healthy humans. Bilateral dorsolateral prefrontal cortex (Brodmann's area [BA] 9) was more active during a verbal recency judgment task than during a non-mnemonic control task. Activation related to temporal context recognition was also observed in midline supplementary motor area (BA 6) and left precuneus (BA 7). This study provides further evidence that memory for temporal context requires the prefrontal cortex and is the first to demonstrate this association in healthy humans. The current findings also suggest the possibility that recognition of context and recognition of episodic content may involve similar brain systems.
@Article{Zorrilla1996,
  author   = {L. T. Zorrilla and G. K. Aguirre and E. Zarahn and T. D. Cannon and M. D'Esposito},
  journal  = {Neuroreport},
  title    = {Activation of the prefrontal cortex during judgments of recency: a functional {MRI} study.},
  year     = {1996},
  number   = {15-17},
  pages    = {2803-6},
  volume   = {7},
  abstract = {Animal and human lesion studies have consistently shown that damage
	to the prefrontal lobe disrupts performance on tasks requiring memory
	for temporal context. In this study, functional magnetic resonance
	imaging (fMRI) was used to explore the brain regions associated with
	judgements of relative recency in healthy humans. Bilateral dorsolateral
	prefrontal cortex (Brodmann's area [BA] 9) was more active during
	a verbal recency judgment task than during a non-mnemonic control
	task. Activation related to temporal context recognition was also
	observed in midline supplementary motor area (BA 6) and left precuneus
	(BA 7). This study provides further evidence that memory for temporal
	context requires the prefrontal cortex and is the first to demonstrate
	this association in healthy humans. The current findings also suggest
	the possibility that recognition of context and recognition of episodic
	content may involve similar brain systems.},
  keywords = {Adult, Female, Humans, Judgment, Magnetic Resonance Imaging, Male, Prefrontal Cortex, 8981471},
}

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