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@article{chea_listening_2024, title = {Listening to classical music influences brain connectivity in post-stroke aphasia: {A} pilot study}, volume = {67}, issn = {1877-0657}, shorttitle = {Listening to classical music influences brain connectivity in post-stroke aphasia}, url = {https://www.sciencedirect.com/science/article/pii/S1877065724000095}, doi = {10.1016/j.rehab.2024.101825}, number = {4}, urldate = {2024-03-12}, journal = {Annals of Physical and Rehabilitation Medicine}, author = {Chea, Maryane and Ben Salah, Amina and Toba, Monica N. and Zeineldin, Ryan and Kaufmann, Brigitte and Weill-Chounlamountry, Agnès and Naccache, Lionel and Bayen, Eléonore and Bartolomeo, Paolo}, month = may, year = {2024}, keywords = {Aphasia, Brain connectivity, Music-assisted rehabilitation, Stroke rehabilitation}, pages = {101825}, }
@article{spagna_visual_2024, title = {Visual mental imagery: {Evidence} for a heterarchical neural architecture}, volume = {48}, issn = {1571-0645}, shorttitle = {Visual mental imagery}, url = {https://www.sciencedirect.com/science/article/pii/S157106452300218X}, doi = {10.1016/j.plrev.2023.12.012}, abstract = {Theories of Visual Mental Imagery (VMI) emphasize the processes of retrieval, modification, and recombination of sensory information from long-term memory. Yet, only few studies have focused on the behavioral mechanisms and neural correlates supporting VMI of stimuli from different semantic domains. Therefore, we currently have a limited understanding of how the brain generates and maintains mental representations of colors, faces, shapes - to name a few. Such an undetermined scenario renders unclear the organizational structure of neural circuits supporting VMI, including the role of the early visual cortex. We aimed to fill this gap by reviewing the scientific literature of five semantic domains: visuospatial, face, colors, shapes, and letters imagery. Linking theory to evidence from over 60 different experimental designs, this review highlights three main points. First, there is no consistent activity in the early visual cortex across all VMI domains, contrary to the prediction of the dominant model. Second, there is consistent activity of the frontoparietal networks and the left hemisphere's fusiform gyrus during voluntary VMI irrespective of the semantic domain investigated. We propose that these structures are part of a domain-general VMI sub-network. Third, domain-specific information engages specific regions of the ventral and dorsal cortical visual pathways. These regions partly overlap with those found in visual perception studies (e.g., fusiform face area for faces imagery; lingual gyrus for color imagery). Altogether, the reviewed evidence suggests the existence of domain-general and domain-specific mechanisms of VMI selectively engaged by stimulus-specific properties (e.g., colors or faces). These mechanisms would be supported by an organizational structure mixing vertical and horizontal connections (heterarchy) between sub-networks for specific stimulus domains. Such a heterarchical organization of VMI makes different predictions from current models of VMI as reversed perception. Our conclusions set the stage for future research, which should aim to characterize the spatiotemporal dynamics and interactions among key regions of this architecture giving rise to visual mental images.}, urldate = {2024-01-15}, journal = {Physics of Life Reviews}, author = {Spagna, Alfredo and Heidenry, Zoe and Miselevich, Michelle and Lambert, Chloe and Eisenstadt, Benjamin E. and Tremblay, Laura and Liu, Zixin and Liu, Jianghao and Bartolomeo, Paolo}, month = mar, year = {2024}, keywords = {Domain-preferring regions, Frontoparietal attention networks, Fusiform imagery node, Visual mental imagery, heterarchy}, pages = {113--131}, }
@article{bartolomeo_colors_2024, title = {Colors in the mind’s eye}, volume = {170}, issn = {00109452}, url = {https://linkinghub.elsevier.com/retrieve/pii/S0010945223002435}, doi = {10.1016/j.cortex.2023.10.002}, abstract = {The famous "Piazza del Duomo" paper, published in Cortex in 1978, inspired a considerable amount of research on visual mental imagery in brain-damaged patients. As a consequence, single-case reports featuring dissociations between perceptual and imagery abilities challenged the prevailing model of visual mental imagery. Here we focus on mental imagery for colors. A case study published in Cortex showed perfectly preserved color imagery in a patient with acquired achromatopsia after bilateral lesions at the borders between the occipital and temporal cortex. Subsequent neuroimaging findings in healthy participants extended and specified this result; color imagery elicited activation in both a domain-general region located in the left fusiform gyrus and the anterior color-biased patch within the ventral temporal cortex, but not in more posterior color-biased patches. Detailed studies of individual neurological patients, as those often published in Cortex, are still critical to inspire and constrain neurocognitive research and its theoretical models.}, language = {en}, urldate = {2024-01-11}, journal = {Cortex}, author = {Bartolomeo, Paolo and Liu, Jianghao and Spagna, Alfredo}, month = jan, year = {2024}, pages = {26--31}, }
@article{seidel_malkinson_intracortical_2024, title = {Intracortical recordings reveal vision-to-action cortical gradients driving human exogenous attention}, shorttitle = {From perception to action}, url = {http://biorxiv.org/lookup/doi/10.1101/2021.01.02.425103}, abstract = {Exogenous attention, the process that makes external salient stimuli pop-out of a visual scene, is essential for survival. How attention-capturing events modulate processing dynamics in the human brain remains elusive. We obtained a comprehensive depiction of attentional cortical dynamics at high spatiotemporal resolution, by analyzing brain activity from 1,403 intracortical contacts implanted in 28 individuals, while they performed an exogenous attention task. The timing, location and task-relevance of attentional events defined a spatiotemporal continuum of three neural clusters, which mapped onto cortical core-periphery gradients. Attentional effects emerged at the gradient center, where neural activity reflected both visual input and motor output. These results reveal how large-scale neural ensembles, embedded in the cortical hierarchy, underlie the psychological construct of exogenous attention in the human brain.}, language = {en}, urldate = {2023-01-03}, journal = {Nature Communications}, author = {Seidel Malkinson, Tal and Bayle, Dimitri J. and Kaufmann, Brigitte C. and Liu, Jianghao and Bourgeois, Alexia and Lehongre, Katia and Fernandez-Vidal, Sara and Navarro, Vincent and Adam, Claude and Lambrecq, Virginie and Margulies, Daniel S. and Sitt, Jacobo D. and Bartolomeo, Paolo}, year = {2024}, doi = {10.1101/2021.01.02.425103}, keywords = {⛔ No DOI found}, }
@misc{messaoud_low-dimensional_2023, title = {Low-dimensional controllability of brain networks}, url = {http://arxiv.org/abs/2311.11132}, abstract = {Network controllability is a powerful tool to study causal relationships in complex systems and identify the driver nodes for steering the network dynamics into desired states. However, due to ill-posed conditions, results become unreliable when the number of drivers becomes too small compared to the network size. This is a very common situation, particularly in real-world applications, where the possibility to access multiple nodes at the same time is limited by technological constraints, such as in the human brain. Although targeting smaller network parts might improve accuracy, challenges may remain for extremely unbalanced situations, when for example there is one single driver. To address this problem, we developed a mathematical framework that combines concepts from spectral graph theory and modern network science. Instead of controlling the original network dynamics, we aimed to control its low-dimensional embedding into the topological space derived from the network Laplacian. By performing extensive simulations on synthetic networks, we showed that a relatively low number of projected components is enough to improve the overall control accuracy, notably when dealing with very few drivers. Based on these findings, we introduced alternative low-dimensional controllability metrics and used them to identify the main driver areas of the human connectome obtained from N=6134 healthy individuals in the UK-biobank cohort. Results revealed previously unappreciated influential regions compared to standard approaches, enabled to draw control maps between distinct specialized large-scale brain systems, and yielded an anatomically-based understanding of hemispheric functional lateralization. Taken together, our results offered a theoretically-grounded solution to deal with network controllability in real-life applications and provided insights into the causal interactions of the human brain.}, urldate = {2024-02-28}, publisher = {arXiv}, author = {Messaoud, Remy Ben and Du, Vincent Le and Kaufmann, Brigitte Charlotte and Couvy-Duchesne, Baptiste and Migliaccio, Lara and Bartolomeo, Paolo and Chavez, Mario and Fallani, Fabrizio De Vico}, month = nov, year = {2023}, note = {arXiv:2311.11132 [q-bio]}, keywords = {Quantitative Biology - Neurons and Cognition, Quantitative Biology - Quantitative Methods}, }
@misc{liu_visual_2023, title = {Visual mental imagery in typical imagers and in aphantasia: {A} millimeter-scale 7-{T} {fMRI} study}, copyright = {© 2023, Posted by Cold Spring Harbor Laboratory. This pre-print is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), CC BY-NC 4.0, as described at http://creativecommons.org/licenses/by-nc/4.0/}, shorttitle = {Visual mental imagery in typical imagers and in aphantasia}, url = {https://www.biorxiv.org/content/10.1101/2023.06.14.544909v4}, doi = {10.1101/2023.06.14.544909}, abstract = {Most of us effortlessly describe visual objects, whether seen or remembered. Yet, around 4\% of people report congenital aphantasia: they struggle to visualize objects despite being able to describe their visual appearance. What neural mechanisms create this disparity between subjective experience and objective performance? Aphantasia can provide novel insights into conscious processing and awareness. We used ultra-high field 7T fMRI to establish the neural circuits involved in visual mental imagery and perception, and to elucidate the neural mechanisms associated with the processing of internally generated visual information in the absence of imagery experience in congenital aphantasia. Ten typical imagers and 10 aphantasic individuals performed imagery and perceptual tasks in five domains: object shape, object color, written words, faces, and spatial relationships. In typical imagers, imagery tasks activated left-hemisphere fronto-parietal areas, the relevant domain-preferring areas in the ventral temporal cortex partly overlapping with the perceptual domain-preferring areas, and a domain-general area in the left fusiform gyrus (the Fusiform Imagery Node). In aphantasic individuals, imagery activated similar areas, but the Fusiform Imagery Node was functionally disconnected from fronto-parietal areas. Our results unveil the domain-general and domain-specific circuits of visual mental imagery, their functional disorganization in aphantasia, and support the general hypothesis that conscious visual experience - whether perceived or imagined - depends on the integrated activity of high-level visual cortex and fronto-parietal networks.}, language = {en}, urldate = {2023-12-13}, publisher = {bioRxiv}, author = {Liu, Jianghao and Zhan, Minye and Hajhajate, Dounia and Spagna, Alfredo and Dehaene, Stanislas and Cohen, Laurent and Bartolomeo, Paolo}, month = oct, year = {2023}, note = {Pages: 2023.06.14.544909 Section: New Results}, }
@article{spagna_cost_2023, title = {The cost of attentional reorienting on conscious visual perception: an {MEG} study}, volume = {33}, issn = {1047-3211}, shorttitle = {The cost of attentional reorienting on conscious visual perception}, url = {https://doi.org/10.1093/cercor/bhac192}, doi = {10.1093/cercor/bhac192}, abstract = {How do attentional networks influence conscious perception? To answer this question, we used magnetoencephalography in human participants and assessed the effects of spatially nonpredictive or predictive supra-threshold peripheral cues on the conscious perception of near-threshold Gabors. Three main results emerged. (i) As compared with invalid cues, both nonpredictive and predictive valid cues increased conscious detection. Yet, only predictive cues shifted the response criterion toward a more liberal decision (i.e. willingness to report the presence of a target under conditions of greater perceptual uncertainty) and affected target contrast leading to 50\% detections. (ii) Conscious perception following valid predictive cues was associated to enhanced activity in frontoparietal networks. These responses were lateralized to the left hemisphere during attentional orienting and to the right hemisphere during target processing. The involvement of frontoparietal networks occurred earlier in valid than in invalid trials, a possible neural marker of the cost of re-orienting attention. (iii) When detected targets were preceded by invalid predictive cues, and thus reorienting to the target was required, neural responses occurred in left hemisphere temporo-occipital regions during attentional orienting, and in right hemisphere anterior insular and temporo-occipital regions during target processing. These results confirm and specify the role of frontoparietal networks in modulating conscious processing and detail how invalid orienting of spatial attention disrupts conscious processing.}, number = {5}, urldate = {2023-12-09}, journal = {Cerebral Cortex}, author = {Spagna, Alfredo and Bayle, Dimitri J and Romeo, Zaira and Seidel-Malkinson, Tal and Liu, Jianghao and Yahia-Cherif, Lydia and Chica, Ana B and Bartolomeo, Paolo}, month = mar, year = {2023}, pages = {2048--2060}, }
@article{zeraati_intrinsic_2023, title = {Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity}, volume = {14}, issn = {2041-1723}, url = {https://www.nature.com/articles/s41467-023-37613-7}, doi = {10.1038/s41467-023-37613-7}, abstract = {Abstract Intrinsic timescales characterize dynamics of endogenous fluctuations in neural activity. Variation of intrinsic timescales across the neocortex reflects functional specialization of cortical areas, but less is known about how intrinsic timescales change during cognitive tasks. We measured intrinsic timescales of local spiking activity within columns of area V4 in male monkeys performing spatial attention tasks. The ongoing spiking activity unfolded across at least two distinct timescales, fast and slow. The slow timescale increased when monkeys attended to the receptive fields location and correlated with reaction times. By evaluating predictions of several network models, we found that spatiotemporal correlations in V4 activity were best explained by the model in which multiple timescales arise from recurrent interactions shaped by spatially arranged connectivity, and attentional modulation of timescales results from an increase in the efficacy of recurrent interactions. Our results suggest that multiple timescales may arise from the spatial connectivity in the visual cortex and flexibly change with the cognitive state due to dynamic effective interactions between neurons.}, language = {en}, number = {1}, urldate = {2023-12-08}, journal = {Nature Communications}, author = {Zeraati, Roxana and Shi, Yan-Liang and Steinmetz, Nicholas A. and Gieselmann, Marc A. and Thiele, Alexander and Moore, Tirin and Levina, Anna and Engel, Tatiana A.}, month = apr, year = {2023}, pages = {1858}, }
@article{bartolomeo_definition_2023, title = {Definition: {Object} color agnosia}, volume = {167}, issn = {00109452}, shorttitle = {Definition}, url = {https://linkinghub.elsevier.com/retrieve/pii/S0010945223001740}, doi = {10.1016/j.cortex.2023.07.002}, language = {en}, urldate = {2023-10-04}, journal = {Cortex}, author = {Bartolomeo, Paolo and Miceli, Gabriele}, month = oct, year = {2023}, pages = {65}, }
@book{bartolomeo_dernieres_2023, title = {Dernières nouvelles du cerveau}, url = {https://editions.flammarion.com/dernieres-nouvelles-du-cerveau/9782080270467}, abstract = {Dernières nouvelles du cerveau : présentation du livre de Paolo Bartolomeo publié aux Editions Flammarion. Comment naît le langage ? Quelle est l’origine de la conscience ? Pourra-t-on bientôt lire dans nos rêves et nos pensées en enregistrant l’activité de nos neurones ? Comment apprend-on ? Et qu’est-ce que le connectome ?Fascinant par sa complexité, le cerveau reste un objet mystérieux pour}, language = {fr}, urldate = {2023-09-05}, publisher = {Editions Flammarion}, author = {Bartolomeo, Paolo}, year = {2023}, }
@article{botta_attentional_2022, title = {Attentional distraction affects maintenance of information in visual sensory memory}, volume = {107}, issn = {1090-2376}, doi = {10.1016/j.concog.2022.103453}, abstract = {Classical theoretical models suggest that visual short-term memory can be divided in two main memory systems: sensory memory, a short-lasting but high-capacity memory storage and working memory, a long-lasting but low-capacity memory store. Whilst, previous research has systematically shown a strong interplay between attentional mechanisms and working memory, less clear is the role of attention in sensory memory. In the present study we approach this issue by asking whether withdrawing attentional resources by a dual task (Experiment 1) or by presenting task irrelevant information during memory maintenance (Experiment 2 and 3) similarly or differently affect sensory and working memory. Overall, results showed that sensory memory content was undermined not only by a simultaneous high-demanding cognitive task but even when purely task-irrelevant and non-masking visual distractors were presented during maintenance. Our data provide support against theories that consider sensory memories as a case of visual awareness free of attention.}, language = {eng}, journal = {Consciousness and Cognition}, author = {Botta, Fabiano and Arévalo, Elisa Martín and Bartolomeo, Paolo and Lupiáñez, Juan}, month = dec, year = {2022}, note = {https://www.dropbox.com/s/4n10uapejq75lab/Botta\%20et\%20al\_2022\_Attentional\%20distraction\%20affects\%20maintenance\%20of\%20information\%20in\%20visual\%20sensory.pdf?dl=0}, keywords = {\#nosource, Attention, Consciousness, Distraction, Sensory memory, Visual short-term memory}, pages = {103453}, }
@article{hajhajate_connectional_2022, title = {The connectional anatomy of visual mental imagery: evidence from a patient with left occipito-temporal damage}, volume = {227}, issn = {1863-2661}, shorttitle = {The connectional anatomy of visual mental imagery}, url = {https://pubmed.ncbi.nlm.nih.gov/35622159/}, doi = {10.1007/s00429-022-02505-x}, abstract = {Most of us can use our "mind's eye" to mentally visualize things that are not in our direct line of sight, an ability known as visual mental imagery. Extensive left temporal damage can impair patients' visual mental imagery experience, but the critical locus of lesion is unknown. Our recent meta-ana …}, language = {en}, number = {9}, urldate = {2023-09-14}, journal = {Brain structure \& function}, author = {Hajhajate, D. and Kaufmann, B.C. and Liu, J. and Siuda-Krzywicka, K. and Bartolomeo, P.}, month = dec, year = {2022}, pmid = {35622159}, note = {Publisher: Brain Struct Funct}, pages = {3075--3083}, }
@article{kaufmann_joint_2022, title = {Joint impact on attention, alertness and inhibition of lesions at a frontal white matter crossroad}, volume = {146}, issn = {0006-8950, 1460-2156}, url = {https://academic.oup.com/brain/article/146/4/1467/6749030}, doi = {10.1093/brain/awac359}, abstract = {Abstract In everyday life, information from different cognitive domains—such as visuospatial attention, alertness and inhibition—needs to be integrated between different brain regions. Early models suggested that completely segregated brain networks control these three cognitive domains. However, more recent accounts, mainly based on neuroimaging data in healthy participants, indicate that different tasks lead to specific patterns of activation within the same, higher-order and ‘multiple-demand’ network. If so, then a lesion to critical substrates of this common network should determine a concomitant impairment in all three cognitive domains. The aim of the present study was to critically investigate this hypothesis, i.e. to identify focal stroke lesions within the network that can concomitantly affect visuospatial attention, alertness and inhibition. We studied an unselected sample of 60 first-ever right-hemispheric, subacute stroke patients using a data-driven, bottom-up approach. Patients performed 12 standardized neuropsychological and oculomotor tests, four per cognitive domain. A principal component analysis revealed a strong relationship between all three cognitive domains: 10 of 12 tests loaded on a first, common component. Analysis of the neuroanatomical lesion correlates using different approaches (i.e. voxel-based and tractwise lesion-symptom mapping, disconnectome maps) provided convergent evidence on the association between severe impairment of this common component and lesions at the intersection of superior longitudinal fasciculus II and III, frontal aslant tract and, to a lesser extent, the putamen and inferior fronto-occipital fasciculus. Moreover, patients with a lesion involving this region were significantly more impaired in daily living cognition, which provides an ecological validation of our results. A probabilistic functional atlas of the multiple-demand network was performed to confirm the potential relationship between patients’ lesion substrates and observed cognitive impairments as a function of the multiple-demand network connectivity disruption. These findings show, for the first time, that a lesion to a specific white matter crossroad can determine a concurrent breakdown in all three considered cognitive domains. Our results support the multiple-demand network model, proposing that different cognitive operations depend on specific collaborators and their interaction, within the same underlying neural network. Our findings also extend this hypothesis by showing (i) the contribution of superior longitudinal fasciculus and frontal aslant tract to the multiple-demand network; and (ii) a critical neuroanatomical intersection, crossed by a vast amount of long-range white matter tracts, many of which interconnect cortical areas of the multiple-demand network. The vulnerability of this crossroad to stroke has specific cognitive and clinical consequences; this has the potential to influence future rehabilitative approaches.}, language = {en}, number = {4}, urldate = {2023-04-13}, journal = {Brain}, author = {Kaufmann, Brigitte C and Cazzoli, Dario and Pastore-Wapp, Manuela and Vanbellingen, Tim and Pflugshaupt, Tobias and Bauer, Daniel and Müri, René M and Nef, Tobias and Bartolomeo, Paolo and Nyffeler, Thomas}, year = {2022}, pages = {1467--1482}, }
@article{bassignana_impact_2022, title = {The impact of aging on human brain network target controllability}, volume = {227}, issn = {1863-2661}, url = {https://doi.org/10.1007/s00429-022-02584-w}, doi = {10.1007/s00429-022-02584-w}, abstract = {Understanding how few distributed areas can steer large-scale brain activity is a fundamental question that has practical implications, which range from inducing specific patterns of behavior to counteracting disease. Recent endeavors based on network controllability provided fresh insights into the potential ability of single regions to influence whole brain dynamics through the underlying structural connectome. However, controlling the entire brain activity is often unfeasible and might not always be necessary. The question whether single areas can control specific target subsystems remains crucial, albeit still poorly explored. Furthermore, the structure of the brain network exhibits progressive changes across the lifespan, but little is known about the possible consequences in the controllability properties. To address these questions, we adopted a novel target controllability approach that quantifies the centrality of brain nodes in controlling specific target anatomo-functional systems. We then studied such target control centrality in human connectomes obtained from healthy individuals aged from 5 to 85. Main results showed that the sensorimotor system has a high influencing capacity, but it is difficult for other areas to influence it. Furthermore, we reported that target control centrality varies with age and that temporal-parietal regions, whose cortical thinning is crucial in dementia-related diseases, exhibit lower values in older people. By simulating targeted attacks, such as those occurring in focal stroke, we showed that the ipsilesional hemisphere is the most affected one regardless of the damaged area. Notably, such degradation in target control centrality was more evident in younger people, thus supporting early-vulnerability hypotheses after stroke.}, language = {en}, number = {9}, urldate = {2023-08-24}, journal = {Brain Structure and Function}, author = {Bassignana, Giulia and Lacidogna, Giordano and Bartolomeo, Paolo and Colliot, Olivier and De Vico Fallani, Fabrizio}, month = dec, year = {2022}, keywords = {Aging, Brain connectivity, MRI, Network controllability, Simulation, Stroke}, pages = {3001--3015}, }
@article{lunven_attention_2017, series = {Spatial {Cognition} / {Coordinated} by {Gilles} {Rode}, {Dominic} {Perennou}, {Philippe} {Azouvi}}, title = {Attention and spatial cognition: {Neural} and anatomical substrates of visual neglect}, volume = {60}, issn = {1877-0657}, shorttitle = {Attention and spatial cognition}, url = {https://www.sciencedirect.com/science/article/pii/S1877065716000178}, doi = {10.1016/j.rehab.2016.01.004}, abstract = {Unilateral spatial neglect (USN) is a neurological disorder often observed following damage to the right cerebral hemisphere. Patients with USN are no longer able to take into account stimuli presented on the left side of space. In this article, we will discuss the neuroanatomical correlates that underlie visuospatial attention and can cause USN, an area of growing research interest in the past 20 years. This syndrome has often been related to cortical damage, notably in the inferior parietal lobule. Other data have also implicated lesions in the inferior frontal gyrus or the superior temporal gyrus. In this article, we will highlight the relevance of viewing USN as a disconnection syndrome of interconnected cerebral areas, as opposed to a focal cortical syndrome. We will review data that provide evidence of intrahemispheric disconnection, in particular within the right hemisphere's frontoparietal networks connected by the superior longitudinal fasciculus. Recent findings suggest that interhemispheric disconnection could also contribute to the manifestations of USN. Most importantly, interhemispheric disconnection might be a predictive factor for the chronicity of this disorder. This hypothesis implies that the left hemisphere by itself is not able to compensate for the patients’ deficits. Recovery requires the ability to exchange information between the two hemispheres, particularly in the posterior parietal and occipital regions.}, number = {3}, urldate = {2023-11-10}, journal = {Annals of Physical and Rehabilitation Medicine}, author = {Lunven, Marine and Bartolomeo, Paolo}, month = jun, year = {2017}, keywords = {Chronic neglect, Frontoparietal network, Interhemispheric disconnection, Visual neglect, Visuospatial attention}, pages = {124--129}, }
@article{chica_interactions_2016, title = {Interactions between phasic alerting and consciousness in the fronto-striatal network}, volume = {6}, copyright = {2016 The Author(s)}, issn = {2045-2322}, url = {https://www.nature.com/articles/srep31868}, doi = {10.1038/srep31868}, abstract = {Only a small fraction of all the information reaching our senses can be the object of conscious report or voluntary action. Although some models propose that different attentional states (top-down amplification and vigilance) are necessary for conscious perception, few studies have explored how the brain activations associated with different attentional systems (such as top-down orienting and phasic alerting) lead to conscious perception of subsequent visual stimulation. The aim of the present study was to investigate the neural mechanisms associated with endogenous spatial attention and phasic alertness and their interaction with the conscious perception of near-threshold stimuli. The only region demonstrating a neural interaction between endogenous attention and conscious perception was the thalamus, while a larger network of cortical and subcortical brain activations, typically associated with phasic alerting, was highly correlated with participants’ conscious reports. Activation of the anterior cingulate cortex, supplementary motor area, frontal eye fields, thalamus and caudate nucleus was related to perceptual consciousness. These data suggest that not all attentional systems are equally effective in enhancing conscious perception, highlighting the importance of thalamo-cortical circuits on the interactions between alerting and consciousness.}, language = {en}, number = {1}, urldate = {2023-12-09}, journal = {Scientific Reports}, author = {Chica, Ana B. and Bayle, Dimitri J. and Botta, Fabiano and Bartolomeo, Paolo and Paz-Alonso, Pedro M.}, month = aug, year = {2016}, note = {Number: 1 Publisher: Nature Publishing Group}, keywords = {Attention, Consciousness}, pages = {31868}, }
@article{chica_role_2014, title = {On the role of the ventral attention system in spatial orienting}, volume = {8}, issn = {1662-5161}, url = {https://www.frontiersin.org/articles/10.3389/fnhum.2014.00235}, doi = {10.3389/fnhum.2014.00235}, urldate = {2023-05-24}, journal = {Frontiers in Human Neuroscience}, author = {Chica, Ana B. and Bourgeois, Alexia and Bartolomeo, Paolo}, year = {2014}, }
@article{chica_neural_2013, title = {Neural bases of the interactions between spatial attention and conscious perception}, volume = {23}, issn = {1460-2199}, doi = {10.1093/cercor/bhs087}, abstract = {Recent behavioral observations suggest that some forms of attentional orienting have the ability to modulate access to perceptual consciousness. However, the neural structures subserving such processes remain uncertain. We used functional magnetic resonance imaging during a visual discrimination task with near-threshold targets preceded by peripheral cues to identify the neural bases of the interactions between spatial attention and conscious visual perception. During the cue-target period critical for spatial orienting, regions within a frontoparietal network, including nodes of the dorsal attentional system, were more strongly engaged for consciously perceived targets than for nonperceived targets at attended locations. Moreover, activation increased for "unseen" targets in more ventral frontoparietal regions, known to be part of a system involved in attentional reorienting. Functional connectivity analyses revealed tighter coupling between frontoparietal nodes for valid cues leading to "seen" reports and for invalid cues leading to unseen reports. We conclude that spatial orienting to peripheral stimuli, subserved by frontoparietal attentional networks, plays a major role in determining the content of our conscious experience.}, language = {eng}, number = {6}, journal = {Cerebral Cortex}, author = {Chica, Ana B. and Paz-Alonso, Pedro M. and Valero-Cabré, Antoni and Bartolomeo, Paolo}, month = jun, year = {2013}, pmid = {22508767}, keywords = {Adult, Analysis of Variance, Attention, Brain, Brain Mapping, Consciousness, Cues, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Orientation, Oxygen, Photic Stimulation, Reaction Time, Reproducibility of Results, Space Perception, Time Factors, Young Adult, conscious perception, dorsal and ventral attentional networks, fMRI, functional connectivity, spatial attention}, pages = {1269--1279}, }
@article{rastelli_neural_2013, title = {Neural dynamics of neglected targets in patients with right hemisphere damage}, volume = {49}, issn = {00109452}, url = {https://linkinghub.elsevier.com/retrieve/pii/S001094521300107X}, doi = {10.1016/j.cortex.2013.04.001}, abstract = {We studied the neural correlates of target omissions in five patients with right hemisphere damage and varying signs of left spatial neglect. Benefiting from the high temporal resolution of magneto-encephalography, we directly compared brain regional synchrony events of detected and omitted left-sided targets. Results showed that before stimulus presentation, a low beta synchronization activity was specifically increased within left frontal areas before pathological response omissions of left-sided targets. In the same prestimulus period, there were no such beta oscillations when patients correctly detected the target, or when no target was presented. Our findings emphasize the importance of neural activity during the pre-stimulus period on subsequent stimulus processing, and highlight the consequences of episodic interruptions of large-scale interhemispheric networks on target detection. Furthermore, our data suggest that prefrontal activity is not necessarily beneficial to target detection, but can be detrimental to it.}, language = {en}, number = {7}, urldate = {2023-08-25}, journal = {Cortex}, author = {Rastelli, Federica and Tallon-Baudry, Catherine and Migliaccio, Raffaella and Toba, Monica N. and Ducorps, Antoine and Pradat-Diehl, Pascale and Duret, Christophe and Dubois, Bruno and Valero-Cabré, Antoni and Bartolomeo, Paolo}, month = jul, year = {2013}, pages = {1989--1996}, }
@article{antonietti_rapporti_2008, title = {Rapporti tra capacità percettive e immaginative nell'anziano}, volume = {1-2}, journal = {Ricerche di Psicologia}, author = {Antonietti, A. and Bartolomeo, P. and Colombi, A. and Incorpora, C. and Oliveri, S.}, year = {2008}, keywords = {\#nosource, ⛔ No DOI found}, pages = {105--120}, }
@article{bartolomeo_varieties_2008, title = {Varieties of attention and of consciousness: {Evidence} from neuropsychology}, volume = {14}, url = {http://www.theassc.org/vol_14_2008}, abstract = {Do we need to attend to an object in order to be conscious of it, and are the objects of our attention necessarily part of our conscious experience? A tight link between attention and consciousness has often been assumed, but it has recently been questioned, on the basis of psychophysical evidence suggesting a double dissociation between top-down attention and consciousness. The present review proposes to consider these issues in the light of time-honored distinctions between exogenous and endogenous forms of attention and between primary and reflective forms of consciousness. These distinctions shed light on results from several sources of evidence, including patterns of performance of brain-damaged patients with visual neglect. These findings strongly suggest that exogenous attention is a necessary condition for primary visual consciousness to emerge. Visual neglect, which typically results from damage to fronto-parietal networks in the right hemisphere, entails an inability to orient to and to detect contralesional objects. Importantly, neglect patients are not only unable to verbally report contralesional objects, but may also act as if these objects did not exist, for example by bumping into them, thus suggesting an impairment of primary perceptual consciousness. Less frequently, neglect patients may instead show forms of “implicit” knowledge of neglected items, perhaps indicating a deficit of more reflective forms of consciousness, such as those subserving verbal reportability. The integration of several sources of evidence, such as phenomenology, experimental psychology and neuroscience, is needed to further explore the taxonomy of these processes and to identify their neural correlates.}, number = {1}, journal = {Psyche}, author = {Bartolomeo, P.}, year = {2008}, keywords = {Attention, Brain-damaged patients, Space processing, Unilateral neglect, ⛔ No DOI found}, }
@article{urbanski_brain_2007, title = {Brain networks of spatial awareness: {Evidence} from diffusion tensor imaging tractography}, issn = {1468330}, abstract = {Left unilateral neglect, a dramatic condition which impairs awareness of left-sided events, has been classically reported after right hemisphere cortical lesions involving the inferior parietal region. More recently, the involvement of long-range white matter tracts has been highlighted, consistent with the idea that awareness of events occurring in space depends on the coordinated activity of anatomically distributed brain regions. Damage to the superior longitudinal fasciculus (SLF), linking parietal to frontal cortical regions, or to the inferior longitudinal fasciculus (ILF), connecting occipital and temporal lobes, have been described in neglect patients. In this study four right-handed patients with right-hemisphere strokes were submitted to a high-definition anatomical MRI with diffusion tensor imaging (DTI) sequences and to a paper-and-pencil neglect battery. We used DTI tractography to visualize the SLF, the ILF and the inferior fronto-occipital fasciculus (IFOF), a pathway running in the depth of the temporal lobe, not hitherto associated with neglect. Two patients with cortical involvement of the inferior parietal and superior temporal regions, but intact and symmetrical fasciculi, showed no signs of neglect. The other two patients with signs of left neglect had superficial damage to the inferior parietal cortex and white matter damage involving the IFOF. These findings suggest that superficial damage to the inferior parietal cortex per se may not be sufficient to produce visual neglect. In some cases, a lesion to the direct connections between ventral occipital and frontal regions (i.e. IFOF) may contribute to the manifestation of neglect by impairing the top-down modulation of visual areas from frontal cortex.}, journal = {J Neurol Neurosurg Psychiatry}, author = {Urbanski, Marika and Thiebaut de Schotten, Michel and Rodrigo, Sebastian and Catani, Marco and Oppenheim, Catherine and Touze, Emmanuel and Chokron, Sylvie and Meder, Jean-Francois and Levy, Richard and Dubois, Bruno and Bartolomeo, Paolo}, month = nov, year = {2007}, keywords = {\#nosource, Aged, 80 and over, Awareness, Cerebral Cortex, Diffusion Magnetic Resonance Imaging, Dominance, Cerebral, Female, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Kinesthesis, Male, Middle Aged, Nerve Fibers, Myelinated, Nerve Net, Perceptual Disorders, Stroke, Unilateral Neglect, Spatial Attention, Diffusion MRI, awareness, ⛔ No DOI found}, }
@article{bartolomeo_left_2007, title = {Left unilateral neglect as a disconnection syndrome}, volume = {17}, issn = {10473211}, doi = {10.1093/cercor/bhl181}, abstract = {Unilateral spatial neglect is a disabling neurological condition that typically results from right hemisphere damage. Neglect patients are unable to take into account information coming from the left side of space. The study of neglect is important for understanding the brain mechanisms of spatial cognition, but its anatomical correlates are currently the object of intense debate. We propose a reappraisal of the contribution of disconnection factors to the pathophysiology of neglect based on a review of animal and patient studies. These indicate that damage to the long-range white matter pathways connecting parietal and frontal areas within the right hemisphere may constitute a crucial antecedent of neglect. Thus, neglect would not result from the dysfunction of a single cortical region but from the disruption of large networks made up of distant cortical regions. In this perspective, we also reexamined the possible contribution to neglect of interhemispheric disconnection. The reviewed evidence, often present in previous studies but frequently overlooked, is consistent with the existence of distributed cortical networks for orienting of attention in the normal brain, has implications for theories of neglect and normal spatial processing, opens perspectives for research on brain-behavior relationships, and suggests new possibilities for patient diagnosis and rehabilitation.}, number = {11}, journal = {Cerebral Cortex}, author = {Bartolomeo, Paolo and Thiebaut de Schotten, Michel and Doricchi, Fabrizio}, month = nov, year = {2007}, keywords = {Animals, Cerebrum, Humans, Models, Neurological, Nerve Fibers, Myelinated, Neural Pathways, Perceptual Disorders, Spatial cognition, Brain lesions, White matter fiber pathways, Attention, Perceptual Disorders, Syndrome}, pages = {2479--90}, }
@article{chokron_experimental_2007, title = {Experimental remission of unilateral spatial neglect}, volume = {45}, issn = {00283932}, doi = {10.1016/j.neuropsychologia.2007.08.001}, abstract = {Over the past several decades a growing amount of research has focused on the possibility of transiently reducing left neglect signs in right brain-damaged patients by using vestibular and/or visuo-proprioceptive stimulations. Here we review seminal papers dealing with these visuo-vestibulo-proprioceptive stimulations in normal controls, right brain-damaged (RBD) patients, and animals. We discuss these data in terms of clinical implications but also with regards to theoretical frameworks commonly used to explain the unilateral neglect syndrome. We undermine the effect of these stimulations on the position of the egocentric reference and extend the notion that the positive effects of these stimulation techniques may stem from a reorientation of attention towards the neglected side of space or from a recalibration of sensori-motor correlations. We conclude this review with discussing the possible interaction between experimental rehabilitation, models of neglect and basic spatial cognition research.}, number = {14}, journal = {Neuropsychologia}, author = {Chokron, Sylvie and Dupierrix, Eve and Tabert, Matthias and Bartolomeo, Paolo}, month = nov, year = {2007}, keywords = {\#nosource, Animals, Functional Laterality, Humans, Nystagmus, Optokinetic, Perceptual Disorders, Spatial Behavior, Transcutaneous Electric Nerve Stimulation, Vestibule, Labyrinth}, pages = {3127--48}, }
@article{azouvi_battery_2006, title = {A battery of tests for the quantitative assessment of unilateral neglect}, volume = {24}, abstract = {Purpose: The lack of agreement regarding assessment methods is responsible for the variability in the reported rate of occurrence of unilateral neglect (UN) after stroke. In addition, dissociations have been reported between performance on traditional paper-and-pencil tests and UN in everyday life situations. Methods: In this paper, we summarize a series of studies with a quantitative test battery for UN, including paper-and-pencil tests, an assessment of personal neglect, extinction, and anosognosia, and a behavioural assessment, the Catherine Bergego Scale (CBS). Results: In healthy subjects, a significant effect of age, education duration and acting hand was found in several tasks. In patients with right hemisphere stroke, the most sensitive paper and pencil measure was the starting point in the cancellation task. The whole battery was more sensitive than any single test alone. An important finding was that behavioural assessment was more sensitive than any other single test. Neglect was two to four times less frequent, but also less severe and less consistent after left hemisphere stroke. Conclusion: Assessment of UN should rely on a battery of quantitative and normalised tests. Some patients may show clinically significant UN in everyday life while obtaining a normal performance on paper-and-pencil measures. This underlines the necessity to use a behavioural assessment of UN.}, number = {4-6}, journal = {Restorative Neurology and Neuroscience}, author = {Azouvi, P. and Bartolomeo, P. and Beis, J.-M. and Perennou, D. and Pradat-Diehl, P. and Rousseaux, M.}, year = {2006}, keywords = {\#nosource, ⛔ No DOI found}, pages = {273--285}, }
@article{bartolomeo_reseau_2006, title = {Un réseau pariéto-frontal droit dédié au traitement de l’espace}, volume = {1}, abstract = {Un réseau pariéto-frontal droit dédié au traitement de l’espace C’est sans effort apparent que nous pouvons explorer notre bureau à la recherche d’un stylo ou lire ce texte. Cela pourrait nous donner l’impression que les mécanismes cérébraux que nous utilisons pour percevoir la multitude d’objets situés dans notre espace visuel ou pour agir sur eux sont relativement simples. Cette impression est illusoire, comme le montrent d’une part les problèmes rencontrés par ceux qui essayent de simuler ces fonctions chez des robots, et d’autre part la complexité d’architecture fonctionnelle des aires visuelles dans le cerveau. Les troubles rencontrés dans la pathologie cérébrale montrent la variété des fonctions et des mécanismes qui sont impliqués dans ces fonctions visuelles « de haut niveau » (par opposition aux processus plus « élémentaires » assumés par les étapes d’élaboration visuelle qui vont de la rétine aux aires visuelles primaires). Certains patients porteurs d’une lésion cérébrale n’arrivent pas à trouver leur stylo s’il est à gauche d’une tasse, bien que leur champ visuel puisse être intact. Environ la moitié des patients porteurs d’une lésion hémisphérique droite, soit plusieurs milliers de cas par an en France, souffre de ce trouble, appelé négligence spatiale unilatérale. Ces patients se comportent comme si la moitié gauche du monde n’existait plus (Fig. 1). Fig. 1. Copie d’un dessin et bissection d’une ligne par un patient présentant une négligence gauche Sur le plan de la santé publique la négligence pose des problèmes importants, du fait qu’elle aggrave le handicap en gênant la rééducation motrice (1). La compréhension des mécanismes de la négligence est importante pour fournir aux cliniciens des outils adaptés au diagnostic et au traitement (rééducation). La recherche sur la négligence peut en outre contribuer à une meilleure compréhension des mécanismes cérébraux du traitement de l’espace et des corrélats neuronaux de la conscience perceptive. Il faut cependant remarquer que l’étude de la négligence spatiale unilatérale est l’un des domaines les plus controversés en neurosciences cognitives, car il n’existe pas de consensus parmi les chercheurs sur les mécanismes de ce syndrome, ni même sur la localisation anatomique des lésions pouvant provoquer une négligence. Après avoir testé différentes hypothèses sur l’origine fonctionnelle des signes de négligence, les résultats de nos travaux ont conclu à une association de déficits attentionnels qui interviennent selon une séquence temporelle spécifique : une attraction « automatique » de l’attention vers la droite suivie d’une difficulté de réorientation vers la gauche (2). L'attention spatiale s’oriente grâce à deux systèmes : le système d’orientation endogène, volontaire et le système de capture exogène, automatique de l’attention. Nos travaux ont démontré que l’orientation exogène est spécialement atteinte dans la négligence gauche, alors que l’orientation endogène est relativement épargnée, mais ralentie (3). Un défi important consiste maintenant à lier les déficits fonctionnels des patients négligents à leurs bases neurales spécifiques. Notre hypothèse d’une atteinte prédominante de l’orientation exogène de l’attention est cohérente avec les résultats de la neuroimagerie fonctionnelle, qui montrent une implication de la jonction temporo-pariétale droite, avec le cortex frontal inférieur, dans la capture exogène de l’attention par un stimulus visuel (4). La jonction temporo-pariétale droite semble effectivement être la localisation lésionnelle typique de la négligence gauche (5). Toutefois, d’autres auteurs, en faisant référence à la distinction entre voie visuelle corticale occipito-pariétale, dédiée aux mouvements pour atteindre un objet visuel, et voie occipito-temporale, utilisée pour l’identification perceptive des objets, font la prédiction que la négligence gauche devrait plutôt résulter d’une atteinte de la voie occipito-temporale, car les mouvements de saisie des objets peuvent être normaux chez ces patients (6). En accord avec cette prédiction, une étude récente a indiqué le gyrus temporal supérieur droit comme base lésionnelle de la négligence (du moins chez les patients n’ayant pas de déficit de champ visuel associé) (7) (Fig. 2). Fig. 2. Lésions critiques donnant lieu à une négligence selon Vallar (5) (en pointillé) et selon Karnath et al. (7) (en blanc) Les lésions des voies de communications entre différentes zones corticales ont reçu moins d’attention (8), bien que la complexité des signes de négligence suggère qu’il s’agit d’une pathologie de réseau plutôt que d’un dysfonctionnement d’une région corticale unique (9). Jusqu’à présent, la méthode anatomo-clinique utilisée pour identifier les lésions donnant lieu à un déficit cognitif était la superposition de lésions vasculaires de plusieurs patients. Cette approche fournit une résolution spatiale assez grossière ; de plus, elle risque de mettre en évidence les territoires d’irroration vasculaire plutôt que les régions importantes d’un point de vue fonctionnel (10). Nous avons récemment pu utiliser une méthode avec une résolution spatio-temporelle bien supérieure. Nous avons testé des patients pendant l’ablation chirurgicale de gliomes cérébraux de bas grade (11). Pour éviter des séquelles cognitives lors de l’ablation de ces tumeurs, le chirurgien peut réveiller les patients pendant l'intervention et inactiver temporairement de petites régions du cerveau (environ 5 mm) avec des stimulations électriques. Si le patient arrête de parler ou produit des réponses incorrectes, le neurochirurgien laisse cette région intacte afin de préserver les fonctions cognitives du patient. Habituellement, seules les fonctions sensori-motrices et le langage sont testées à l’occasion de telles interventions. En appliquant cette procédure aux fonctions visuo-spatiales, nous avons pu explorer directement et précisément les bases neurales de la négligence gauche chez l’homme. Nous avons demandé à deux patients soumis à l’ablation de gliomes situés dans la région temporo-pariétale droite de marquer d’un trait de crayon le centre d’une ligne horizontale. Selon les zones du cerveau inactivées, les traits dessinés par les patients déviaient vers la droite, comme chez les patients avec négligence gauche (voir Fig. 1), ou restaient centrés. En particulier, l’inactivation de deux structures corticales déterminait une déviation. Il s’agissait du gyrus supramarginalis (la partie rostrale du lobule pariétal inférieur) et de la partie caudale du lobe temporal. En revanche, l’inactivation d’une partie plus rostrale du lobe temporal, qui selon Karnath et al. (7) aurait dû être impliquée dans la négligence, ainsi que celle du champ oculomoteur frontal, ne provoquaient pas de déviation significative. Toutefois, les déviations les plus massives (de l’ordre de 30\% de la longueur de l’hémi-segment de droite de la ligne) étaient observées lors de l’inactivation de la substance blanche au fond du lobule pariétal inférieur. Grâce à une technique récente d'imagerie cérébrale, le tracking de fibres, nous avons pu identifier précisément cette région de la substance blanche (Fig. 3). Il s’agissait d’une voie de communication liant les lobes pariétaux et les lobes frontaux du cerveau peu connue à ce jour, appelée le faisceau occipito-frontal supérieur. Cette appellation, qui vient de travaux anciens, semble aujourd’hui impropre, car l’origine postérieure de ce faisceau semble bien être dans le lobe pariétal et non pas dans le lobe occipital du cerveau (12). Ces résultats indiquent que les atteintes de la jonction temporo-pariétale, et surtout des voies de communication pariéto-frontales, sont à l’origine de la survenue de la négligence spatiale unilatérale. De ce fait, ils confirment un modèle neurocognitif influent de la négligence et de l’attention visuo-spatiale chez l’homme (9). Sur le plan clinique, le test de bissection de lignes a permis au chirurgien de respecter les régions dont l'inactivation temporaire donnait lieu à une négligence; par conséquent, les patients étudiés n'ont pas développé de signes de négligence post-opératoire. Ce résultat souligne l'importance de tester en situation intra-opératoire les fonctions visuo-spatiales, et pas seulement les fonctions sensori-motrices ou le langage, chez les patients qui doivent subir l'ablation d'une tumeur cérébrale, afin d’éviter le développement de troubles invalidants du traitement de l’espace. Fig. 3. Reconstruction 3D du cerveau d'un des patients étudiés (11), avec l'exérèse chirurgicale et le faisceau occipito-frontale supérieur, la voie pariéto-frontale dont l'inactivation a provoqué une déviation à droite en bissection de lignes. Références 1. Denes G, Semenza C, Stoppa E, Lis A. Unilateral spatial neglect and recovery from hemiplegia: A follow-up study. Brain 1982;105(3):543-552. 2. Bartolomeo P, Chokron S. Orienting of attention in left unilateral neglect. Neuroscience and Biobehavioral Reviews 2002;26(2):217-234. 3. Bartolomeo P, Siéroff E, Decaix C, Chokron S. Modulating the attentional bias in unilateral neglect: The effects of the strategic set. Experimental Brain Research 2001;137(3/4):424-431. 4. Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews Neuroscience 2002;3(3):201-215. 5. Vallar G. Extrapersonal visual unilateral spatial neglect and its neuroanatomy. Neuroimage 2001;14(1 Pt 2):S52-S58. 6. Milner AD, Goodale MA. The Visual Brain in Action. Oxford: Oxford University Press; 1995. 7. Karnath HO, Ferber S, Himmelbach M. Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature 2001;411(6840):950-963. 8. Doricchi F, Tomaiuolo F. The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? NeuroReport 2003;14(17):2239-2243. 9. Mesulam MM. Spatial attention and neglect: parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Philosophical Transactions of the Royal Society of London B 1999;354(1387):1325-1346. 10. Godefroy O, Duhamel A, Leclerc X, Saint Michel T, Henon H, Leys D. Brain-behaviour relationships. Some models and related statistical procedures for the study of brain-damaged patients. Brain 1998;121 (Pt 8):1545-1556. 11. Thiebaut de Schotten M, Urbanski M, Duffau H, Volle E, Lévy R, Dubois B, et al. Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans. Science 2005;309(5744):2226-2228. 12. Catani M, Howard RJ, Pajevic S, Jones DK. Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 2002;17(1):77-94.}, number = {Juin 2006}, journal = {Actualités en Neurologie}, author = {Bartolomeo, P.}, year = {2006}, keywords = {\#nosource, Unilateral neglect; Attention; Brain-damaged patients; Space processing, ⛔ No DOI found}, }
@article{bartolomeo_inhibitory_2006, title = {Inhibitory after-effects in spatial processing: {Experimental} and theoretical issues on {Inhibition} of {Return}}, volume = {23}, number = {7}, journal = {Cognitive Neuropsychology}, author = {Bartolomeo, P. and Lupiáñez, J.}, year = {2006}, keywords = {\#nosource, ⛔ No DOI found}, }
@article{thiebaut_de_schotten_neuro-anatomy_2006, title = {[{Neuro}-anatomy of space processing]}, volume = {22}, issn = {07670974}, doi = {10.1051/medsci/2006222105}, number = {2}, journal = {Médecine sciences : M/S}, author = {Thiebaut de Schotten, Michel and Bartolomeo, Paolo}, month = feb, year = {2006}, keywords = {\#nosource, Animals, Brain Mapping, Brain Neoplasms, Dominance, Cerebral, Frontal Lobe, Haplorhini, Humans, Neural Pathways, Parietal Lobe, Perceptual Disorders, Space Perception, Temporal Lobe}, pages = {105--7}, }
@article{bartolomeo_review_2005, title = {Review of "{The} cognitive and neural bases of spatial neglect"}, volume = {17}, url = {://000226664000007}, number = {1}, journal = {Eur. J. Cogn. Psychol.}, author = {Bartolomeo, P.}, year = {2005}, keywords = {\#nosource, ⛔ No DOI found}, pages = {151--155}, }
@article{bartolomeo_twenty-five_2005, title = {Twenty-five years of books on spatial neglect: {What} have we learned?}, volume = {17}, number = {1}, journal = {European Journal of Cognitive Psychology}, author = {Bartolomeo, P.}, year = {2005}, keywords = {\#nosource, Book, ⛔ No DOI found}, pages = {151--158}, }
@article{couette_disengage_2005, title = {A disengage deficit of attention in {Huntington}'s disease?}, volume = {76}, url = {://000233316200057}, number = {Suppl. 4}, journal = {Journal of Neurology, Neurosurgery and Psychiatry}, author = {Couette, M. and Bartolomeo, P. and Bachoud-Levi, A.C. and Brugières, P. and Siéroff, E.}, year = {2005}, keywords = {\#nosource, ⛔ No DOI found}, }
@article{bartolomeo_time_2005, title = {Time to imagine space: a chronometric exploration of representational neglect}, volume = {43}, issn = {00283932}, doi = {10.1016/j.neuropsychologia.2004.12.013}, abstract = {When describing known places from memory, patients with left spatial neglect may mention more right- than left-sided items, thus showing representational, or imaginal, neglect. This suggests that these patients cannot either build or explore left locations in visual mental imagery. However, in place description there is no guarantee that patients are really employing visual mental imagery abilities, rather than verbal-propositional knowledge. Thus, patients providing symmetrical descriptions might be using other strategies than visual mental imagery. To address this issue, we devised a new test which strongly encourages the use of visual mental imagery. Twelve participants without brain damage and 12 right brain-damaged patients, of whom 7 had visual neglect, were invited to conjure up a visual mental image of the map of France. They subsequently had to state by pressing a left- or a right-sided key whether auditorily presented towns or regions were situated to the left or right of Paris on the imagined map. This provided measures of response time and accuracy for imagined locations. A further task, devised to assess response bias, used the words "left" or "right" as stimuli and the same keypress responses. Controls and non-neglect patients performed symmetrically. Neglect patients were slower for left than for right imagined locations. On single-case analysis, two patients with visual neglect had a greater response time asymmetry on the geographical task than predicted by the response bias task, but with symmetrical accuracy. The dissociation between response times and accuracy suggests that, in these patients, the left side of the mental map of space was not lost, but only "explored" less efficiently.}, number = {9}, journal = {Neuropsychologia}, author = {Bartolomeo, Paolo and Bachoud-Levi, Anne-Catherine and Azouvi, Philippe and Chokron, Sylvie}, year = {2005}, keywords = {\#nosource, Adult, Aged, Female, Functional Laterality, Humans, Imagery (Psychotherapy), Male, Memory, Middle Aged, Perceptual Disorders, Photic Stimulation, Reaction Time, Space Perception, Task Performance and Analysis, Unilateral neglect; Visual mental imagery; Attention; Brain-damaged patients; Space processing}, pages = {1249--57}, }
@article{bartolomeo_influence_2004, title = {The influence of limb crossing on left tactile extinction}, volume = {75}, issn = {00223050}, abstract = {BACKGROUND: Previous research on patients with left tactile extinction has shown that crossing of hands, so that each hand is on the opposite side of the body midline relative to the other, improves detection of stimuli given to the left hand. OBJECTIVES: To study the influence of the spatial position of limbs on left tactile extinction, and its relations with left visual neglect. METHODS: Normal participants and patients with right cerebral hemisphere damage and left tactile extinction were asked to detect single or double light touch stimuli applied to their cheeks, hands, or knees with their arm and legs either in anatomical or in crossed position, increasing the attentional load of the task. RESULTS: In patients with left extinction, limb crossing caused a deterioration in performance for stimuli applied to right body parts, with only a tendency to an improvement in detection for left body parts (only two of 24 patients showed substantial ({\textgreater}20\%) improvement in left extinction after limb crossing). After crossing, left limb detections of double stimuli decreased with increasing degrees of visual neglect. CONCLUSIONS: In conditions of high attentional load, limb crossing may impair tactile detection in most patients with left extinction, and particularly in those showing signs of left visual neglect. These results underline the importance of general attentional capacity in determining tactile extinction. Attentional and somatotopic mechanisms of extinction may assume different weights in different patients.}, number = {1}, journal = {Journal of neurology, neurosurgery, and psychiatry}, author = {Bartolomeo, P and Perri, R and Gainotti, G}, month = jan, year = {2004}, keywords = {\#nosource, Aged, Aged, 80 and over, Agnosia, Attention, Brain, Female, Functional Laterality, Humans, Male, Middle Aged, Perceptual Disorders, Perceptual disorders, Attention, Somatosensory disorders, Right brain damage, Neglect, Task Performance and Analysis, Touch, ⛔ No DOI found}, pages = {49--55}, }
@article{bartolomeo_negligence_2004, title = {Négligence spatiale unilatérale : compression de l'espace ou biais de l'attention ?}, abstract = {On considère souvent la négligence spatiale unilatérale gauche comme résultant d'un biais d'orientation de l'attention vers la droite. Dans les deux dernières décennies, il a cependant été proposé que la négligence puisse résulter d'un endommagement des processus neuronaux sous-tendant une représentation mentale de l'espace. Une version de l'hypothèse représentationnelle prévoit que le côté gauche de la représentation mentale de l'espace est " compressé ". Ainsi, une patiente avec négligence et hémianopsie gauche qui devait identifier parmi des chiffres disposés horizontalement celui correspondant à l'emplacement d'une flèche située plus bas, indiquait systématiquement un chiffre à droite de la cible, comme si une compression de l'espace gauche déplaçait ses réponses vers la droite (Halligan \& Marshall, Spatial compression in visual neglect: A case study. Cortex, 27(4), 623-629, 1991). Cependant, une interprétation attentionnelle de ces résultats est également possible. En effet, si l'attention de la patiente était attirée par les chiffres situés à droite, cela aurait pu biaiser ses réponses vers ce côté. Nous avons testé cette suggestion en étudiant des patients négligents avec ou sans hémianopsie gauche, des patients hémianopsiques sans négligence, des patients avec lésion cérébrale droite sans troubles visuels ou cognitifs et des sujets normaux. Ces sujets ont marqué dans la marge horizontale (supérieure ou inférieure) d'une feuille l'endroit indiqué par une flèche partant de la marge opposée sous trois conditions: la marge indiquée par la flèche est (1) vide ; (2) segmentée de petits traits verticaux ; (3) contient des chiffres comme dans l'étude originale de Halligan et Marshall. Si la représentation de l'espace est compressée dans la négligence, les performances des patients négligents ne devraient pas varier d'une condition à l'autre ; si la déviation provient d'un biais attentionnel, les patients devraient dévier plus dans la condition avec les cibles visuelles que dans la condition sans cibles, les cibles de droite constituant des objets perceptifs qui devraient attirer l'attention des patients négligents. Les résultats confirment cette dernière prédiction. Seuls les patients négligents dévient vers la droite, et seulement dans les conditions avec cibles visuelles (traits ou chiffres). La déviation est particulièrement importante chez les patients avec négligence plus hémianopsie, car le déficit de champ visuel réduit ultérieurement le nombre de cibles de gauche susceptibles de participer à la compétition. Nos résultats étayent les modèles de traitement de l'espace qui prennent explicitement en considération les interactions compétitives entre objets dans l'espace.}, journal = {Revue Neurologique}, author = {Bartolomeo, P. and Urbanski, M. and Chokron, S. and Chainay, H. and Moroni, C. and Siéroff, E. and Belin, C. and Halligan, P.}, year = {2004}, keywords = {\#nosource, ⛔ No DOI found}, }
@article{chokron_active_2004, title = {Active versus passive proprioceptive straight-ahead pointing in normal subjects}, volume = {55}, issn = {02782626}, doi = {10.1016/j.bandc.2004.02.015}, abstract = {Eighty blindfolded healthy female subjects participated in an active and a passive straight-ahead pointing task to study the estimation of the subjective sagittal middle in the presence or absence of an active haptic exploration. Subjects were to point straight-ahead with their left or right index finger starting from different right- or left-sided locations, while performing either an active movement or with the hand being passively moved by the examiner. Results showed: (i) a significant effect of the hand used only on the active straight-ahead pointing task performance; (ii) a significant effect of the starting position both on the active and passive pointing performance; (iii) a significant correlation between the two protocols only in terms of spatial bias (algebraic error) but not in terms of precision (absolute errors). These results are discussed with regards to normal and neuropsychological studies of the egocentric frame of reference.}, number = {2}, journal = {Brain and cognition}, author = {Chokron, Sylvie and Colliot, Pascale and Atzeni, Thierry and Bartolomeo, Paolo and Ohlmann, Théophile}, month = jul, year = {2004}, keywords = {\#nosource, Adult, EGOREF, Female, Functional Laterality, Hand, Humans, Kinesthesis, Movement, Orientation, Proprioception, Psychomotor Performance, Reference Values, Space Perception, Spatial Behavior}, pages = {290--4}, }
@article{beis_right_2004, title = {Right spatial neglect after left hemisphere stroke: qualitative and quantitative study}, volume = {63}, issn = {1526632}, doi = {10.1212/01.wnl.0000142967.60579.32}, abstract = {OBJECTIVES: Comparatively little research has been conducted on right neglect after left brain damage. The authors sought to assess contralateral neglect in subacute left hemisphere stroke patients using a comprehensive test battery validated in a large control group after right hemisphere stroke. METHODS: Seventy-eight left hemisphere stroke patients were assessed. The test battery included a preliminary assessment of anosognosia and visual extinction, a clinical assessment of gaze orientation and personal neglect, and paper-and-pencil tests of spatial neglect in the peripersonal space. Only nonverbal tests were used. RESULTS: Drawing and cancellation tasks revealed neglect in 10 to 13\% of patients. The combined battery was more sensitive than any single test alone. A total of 43.5\% of patients showed some degree of neglect on at least one measure. Anatomic analyses showed that neglect was more common and severe when the posterior association cortex was damaged. CONCLUSIONS: The frequency of occurrence of right neglect was, as expected, much lower than that reported in a study using the same assessment battery in right brain damage stroke patients. Nevertheless, neglect was found in a substantial proportion of patients at a subacute stage, suggesting that it should be considered in the rehabilitation planning of left brain damage stroke patients.}, number = {9}, journal = {Neurology}, author = {Beis, J-M and Keller, C and Morin, N and Bartolomeo, P and Bernati, T and Chokron, S and Leclercq, M and Louis-Dreyfus, A and Marchal, F and Martin, Y and Perennou, D and Pradat-Diehl, P and Prairial, C and Rode, G and Rousseaux, M and Samuel, C and Siéroff, E and Wiart, L and Azouvi, P}, month = nov, year = {2004}, keywords = {\#nosource, Awareness, Cerebral Cortex, Female, Hemianopsia, Hemiplegia, Humans, Male, Middle Aged, Motor Skills, Stroke}, pages = {1600--5}, }
@article{bartolomeo_review_2003, title = {Review of "{Vision} in the {Brain}", by {Panagiotis} {G}. {Simos}}, volume = {114}, abstract = {As a neurologist interested in disorders of visual attention, I often looked for a reference book covering the neurosciences of the visual system. Panagiotis G. Simos has achieved the impressive task of collecting in a book of 200 pages in length a state-of-art review of such an intimidating topic. As a further bonus, the book offers a final section on the development of the visual system which conveys information which is difficult to find in such a concise form. The author has managed to integrate evidence coming from such disparate research fields as histology, neurophysiology, brain imaging and neuropsychology. After an introductory chapter dedicated to an overview of the methods of visual neuroscience and to terminological issues, there is an ample review of general neuronal functioning and synaptic transmission. The third chapter deals with psychophysical findings, always with reference to "wet" neurosciences. The following three chapters present the anatomy and physiology of the visual pathways, from the retina to the temporal and parietal visual association areas, with some useful reference to visual disorders (visual field defects, prosopagnosia). It is a pity that the author did not go a step further and address the relations between visual association areas and more anterior brain regions, such as the frontal lobes. This would have offered a more general idea - if perhaps speculative - of brain functioning, and of its relation to attentional processes and visual consciousness. The final three chapters are dedicated to the development of the visual brain. The book is written very clearly, and generously illustrated by 81 black-and-white diagrams, even if a few of them lack proper definition and several would have greatly benefited from being in color (e.g., the illustration of brain activation during color processing, picturing two Mondrian displays that should be identical in all respects except that one is colored; in fact, they are identical to the reader, since both appear in shades of gray!). A second edition should add an analytical index and correct a few minor errors, such as the lack of some references in the final list and the statement (page 153) that images are projected in front of the retina in hyperopia, and behind the retina in myopia (in fact, the reverse is true). In conclusion, this book will constitute a useful and handy reference for students and professionals in the fields of visual neuroscience, psychology of perception and neuropsychology, and a valuable addition to the library of ophthalmologists, neurologists and neuropshysiologists.}, number = {4}, journal = {Clinical Neurophysiology}, author = {Bartolomeo, P.}, year = {2003}, keywords = {\#nosource, Book, ⛔ No DOI found}, pages = {750}, }
@article{bartolomeo_modeles_2003, title = {Modèles cognitifs de la négligence spatiale unilatérale}, volume = {159}, abstract = {Les patients ayant une lésion de la partie postérieure de l'hémisphère droit ignorent fréquemment les événements qui surviennent sur leur gauche. Ce phénomène est dénommé négligence spatiale unilatérale. Des déficits situés à de niveaux différents dans les processus cognitifs qui vont de la perception à l'action pourraient être à l'origine de la négligence. Ainsi, on peut imaginer qu'un patient pourrait négliger une moitié du monde du fait : 1. qu'il ne la voit pas (trouble sensoriel) ; 2. qu'il a perdu la moitié gauche d'une représentation cognitive de l'espace (trouble représentationnel) ; 3. qu'un cadre de référence qu'il utilise pour localiser les objets par rapport à soi-même est déplacé vers la droite (trouble référentiel). 4. qu'il a un trouble des mécanismes d'orientation de l'attention spatiale (trouble attentionnel) ; 5. qu'il n'arrive pas à programmer correctement les mouvements des membres dans l'hémi-espace gauche (trouble pré-moteur). Ces possibilités seront passés en revue. Il en résulte que le niveau de déficit le plus plausible reste celui d'une interaction entre plusieurs troubles attentionnels, s'exprimant dans un cadre de référence essentiellement visuo-perceptif. Des avancées récentes dans la connaissance des mécanismes de l'attention spatiale chez les sujets sains peuvent aider à caractériser ces déficits. Une dichotomie particulière est soulignée, celle entre la forme d'orientation de l'attention appelée " exogène ", ou dépendante du stimulus, et celle dite " endogène ", ou dirigée par des stratégies. De nombreuses données issues de la neuropsychologie suggèrent qu'un mécanisme de base du comportement négligent est un déficit de l'orientation exogène vers les cibles présentées sur le côté gauche. D'autre part, les processus d'orientation endogène semblent être relativement préservés, tout en étant ralentis. D'autres types de déficits attentionnels, comme un ralentissement général des opérations de l'attention, peuvent contribuer au comportement des patients négligents.}, number = {Supplément au n° 3}, journal = {Revue Neurologique}, author = {Bartolomeo, P.}, year = {2003}, keywords = {\#nosource, ⛔ No DOI found}, pages = {192}, }
@article{bartolomeo_can_2002, title = {Can attention capture visual awareness? ({Commentary} on {Ruz} and {Lupiáñez}: {A} review of {Attentional} {Capture})}, volume = {23}, url = {http://www.uv.es/psicologica/paraARCHIVES/2002.html}, journal = {Psicológica}, author = {Bartolomeo, P.}, year = {2002}, keywords = {⛔ No DOI found}, pages = {314--317}, }
@article{azouvi_sensitivity_2002, title = {Sensitivity of clinical and behavioural tests of spatial neglect after right hemisphere stroke}, volume = {73}, issn = {00223050}, doi = {10.1136/jnnp.73.2.160}, abstract = {OBJECTIVES: The lack of agreement regarding assessment methods is responsible for the variability in the reported rate of occurrence of spatial neglect after stroke. The aim of this study was to assess the sensitivity of different tests of neglect after right hemisphere stroke. METHODS: Two hundred and six subacute right hemisphere stroke patients were given a test battery including a preliminary assessment of anosognosia and of visual extinction, a clinical assessment of gaze orientation and of personal neglect, and paper and pencil tests of spatial neglect in the peripersonal space. Patients were compared with a previously reported control group. A subgroup of patients (n=69) received a behavioural assessment of neglect in daily life situations. RESULTS: The most sensitive paper and pencil measure was the starting point in the cancellation task. The whole battery was more sensitive than any single test alone. About 85\% of patients presented some degree of neglect on at least one measure. An important finding was that behavioural assessment of neglect in daily life was more sensitive than any other single measure of neglect. Behavioural neglect was considered as moderate to severe in 36\% of cases. A factorial analysis revealed that paper and pencil tests were related to two underlying factors. Dissociations were found between extrapersonal neglect, personal neglect, anosognosia, and extinction. Anatomical analyses showed that neglect was more common and severe when the posterior association cortex was damaged. CONCLUSIONS: The automatic rightward orientation bias is the most sensitive clinical measure of neglect. Behavioural assessment is more sensitive than any single paper and pencil test. The results also support the assumption that neglect is a heterogeneous disorder.}, number = {2}, journal = {Journal of neurology, neurosurgery, and psychiatry}, author = {Azouvi, P and Samuel, C and Louis-Dreyfus, A and Bernati, T and Bartolomeo, P and Beis, J-M and Chokron, S and Leclercq, M and Marchal, F and Martin, Y and De Montety, G and Olivier, S and Perennou, D and Pradat-Diehl, P and Prairial, C and Rode, G and Siéroff, E and Wiart, L and Rousseaux, M}, year = {2002}, keywords = {\#nosource, Activities of Daily Living, Adult, Aged, Attention, Brain Mapping, Cerebral Cortex, Cerebral Hemorrhage, Cerebral Infarction, Female, Humans, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Orientation, Perceptual Disorders, Predictive Value of Tests, Psychomotor Performance, Sensitivity and Specificity}, pages = {160--6}, }
@article{bartolomeo_visually-_2002, title = {Visually- and motor-based knowledge of letters: evidence from a pure alexic patient}, volume = {40}, issn = {00283932}, doi = {10.1016/s0028-3932(01)00209-3}, abstract = {We describe a patient, VSB, whose reading was impaired as a consequence of a left temporal-parietal lesion, whereas writing was relatively preserved. At variance with other pure alexic patients described in the literature, VSB claimed to have become unable to mentally visualise letters and words. Indeed, his performance on a series of tests tapping visual mental imagery for orthographic material was severely impaired. However, performance on the same tests was dramatically ameliorated by allowing VSB to trace each item with his finger. Visual mental imagery for non-orthographic items was comparatively spared. The pattern of dissociation shown by VSB between impaired visual mental imagery and relatively preserved motor-based knowledge for orthographic material lends support to the view that separate codes, respectively based on visual appearance and on motor engrams, may be used to access knowledge of the visual form of letters and words.}, number = {8}, journal = {Neuropsychologia}, author = {Bartolomeo, Paolo and Bachoud-Levi, Anne Catherine and Chokron, Sylvie and Degos, Jean-Denis}, year = {2002}, keywords = {\#nosource, Alexia, Pure, Brain Mapping, Dominance, Cerebral, Humans, Imagination, Male, Middle Aged, Neuropsychological Tests, Orientation, Parietal Lobe, Pattern Recognition, Visual, Psychomotor Performance, Reading, Temporal Lobe, Writing}, pages = {1363--71}, }
@article{rousseaux_presenting_2001, title = {[{Presenting} a battery for assessing spatial neglect. {Norms} and effects of age, educational level, sex, hand and laterality]}, volume = {157}, issn = {00353787}, abstract = {The aim of this study was to build up a battery for assessing spatial neglect, then to analyse the norms and potential effects of age, education level, sex, hand used, and laterality. It was also to contribute evaluating the pseudoneglect phenomenon described by Heilman, which consists in a tendency of normal subjects to neglect the right peripersonal space. Tasks selected were presented to important groups of normal subjects, most often larger than 450. The battery comprised of a bell cancellation test, scene copy, clock drawing, two line bisection tasks, identification of overlapping figures, text reading, writing task, and the representational task of the France map. For each of them, different variables were selected, especially investigating the difference between performance in the right and the left hemispaces. This study allowed defining the threshold values (percentiles 5 and 95) for deciding of the pathological character of a patient performance. It also showed that the pseudoneglect phenomenon is more obvious in some tasks such as line bisection, and probably also in the representational task of the France map and writing. His importance and at times his side were influenced by the factors we studied, with between tasks differences, but also by the nature of the task to be performed, and especially his verbal component.}, number = {11 Pt 1}, journal = {Revue neurologique}, author = {Rousseaux, M and Beis, J M and Pradat-Diehl, P and Martin, Y and Bartolomeo, P and Bernati, T and Chokron, S and Leclercq, M and Louis-Dreyfus, A and Marchal, F and Perennou, D and Prairial, C and Rode, G and Samuel, C and Siéroff, E and Wiart, L and Azouvi, P}, month = nov, year = {2001}, keywords = {\#nosource, Adult, Age Factors, Aged, Analysis of Variance, Diagnosis, Differential, Educational Status, Extinction, Psychological, Female, Functional Laterality, Humans, Male, Middle Aged, Perceptual Disorders, Psychological Tests, Sex Characteristics, Space Perception, ⛔ No DOI found}, pages = {1385--400}, }
@article{bartolomeo_modulating_2001, title = {Modulating the attentional bias in unilateral neglect: the effects of the strategic set}, volume = {137}, issn = {00144819}, abstract = {Left unilateral neglect is a neurological condition characterized by an impairment in orienting and responding to events occurring on the left side. To gain insight into the brain mechanisms of space processing and to provide theoretical foundations for patient rehabilitation, it is important to explore the attentional bias shown by neglect patients in the light of existing models of normal attentional orienting. Three experiments tested the hypothesis that attentional bias in neglect involves primarily exogenous, or stimulus-based, orienting of attention, with relatively preserved endogenous, or voluntary, orienting. Six patients with right hemisphere damage and left unilateral neglect and 18 age-matched participants without brain damage performed a cued reaction time (RT) task to targets which could appear in one of two lateral boxes. Cues consisted of a brief brightening of the contour of one of the boxes. The target followed the cue at 150, 550, or 1000 ms stimulus-onset asynchrony (SOA). In experiment 1, the cues were not informative about the future location of the target, and thus elicited a purely exogenous orienting of attention. Controls showed slowed RTs to the cued locations at SOAs {\textgreater} 150 ms, consistent with the notion of inhibition of return (IOR). Neglect patients had no evidence of IOR for right targets; they showed a disproportionate cost for left targets preceded by right (invalid) cues; this cost was maximal at the shortest SOA, consistent with the idea of a biased exogenous orienting in neglect. In experiment 2, 80\% of the cues were valid (i.e., they correctly predicted the location of the impending target), thus inducing an initially exogenous, and later endogenous, attentional shift toward the cued box. Neglect patients showed again a cost for left invalidly cued targets, which this time persisted at SOAs {\textgreater} 150 ms, as if patients' attention had been cued to the right side not only exogenously, but also endogenously, thus rendering more difficult an endogenous reorienting toward the left. In experiment 3, only 20\% of the cues were valid, so that the best response strategy was to endogenously orient attention toward the box opposite to the cued one. Controls were able to take advantage of invalid cues to rapidly respond to targets. In this condition, neglect patients were able to nullify their spatial bias; they achieved their fastest RTs to left targets, which were in the range of their RTs to right targets. However, for neglect patients fast responses to left targets occurred only at 1000 ms SOA, while controls were able to redirect their attention to the uncued box already at 550 ms SOA. Altogether, these results suggest that endogenous orienting is relatively spared, if slowed, in unilateral neglect.}, number = {3-4}, journal = {Experimental brain research}, author = {Bartolomeo, P and Siéroff, E and Decaix, C and Chokron, S}, month = apr, year = {2001}, keywords = {\#nosource, Adult, Aged, Aged, 80 and over, Attention, Cognition Disorders, Cues, Female, Functional Laterality, Humans, Male, Middle Aged, Orientation, Photic Stimulation, Reaction Time, Stroke, ⛔ No DOI found}, pages = {432--44}, }
@article{bartolomeo_variability_2001, title = {Variability of response times as a marker of diverted attention}, volume = {39}, issn = {00283932}, doi = {10.1016/s0028-3932(00)00135-4}, abstract = {Anderson et al. (Variability not ability: another basis for performance decrements in neglect. Neuropsychologia 2000;38:785-796) have recently reported that variability of response times (RTs) progressively increases from the right to the left side in left neglect patients. Anderson et al. propose that this lack of consistency is an important determinant of patients' behaviour, and may result from a deficit independent of other mechanisms causing neglect. Here we suggest that an increase of variability, and not only of RTs, is to be expected when attention is exogenously biased away from the probed location. Consequently, space-based variability can be interpreted in the framework of existing models of unilateral neglect. According to one such model, a basic impairment in left neglect is a bias toward rightward exogenous orienting of attention. As a result, left targets often fail to rapidly capture patients' attention, thus yielding slow RTs. However, since the probability for a left target attracting attention is low but not null, relatively fast RTs can occur on those rare occasions in which a left target does capture patients' attention. The coexistence of these relatively fast with slow RTs could be at the basis of space-based variability in neglect. Empirical support for our hypothesis comes from the results of a re-analysis for variability of cued RTs obtained in 18 normal individuals and six left neglect patients. Cues were peripheral and non-informative, thus eliciting an exogenous attentional shift. For normal individuals, invalid trials yielded less consistent response times than valid trials at short (150 ms) cue-target interval; for neglect patients, a similar phenomenon occurred for left invalidly-cued targets, thus paralleling the disproportionate cost in RTs typically evoked by this condition in unilateral neglect. We conclude by discussing some possible determinants of gradient-shaped effects and by outlining the implications of space-based variability for current models of unilateral neglect.}, number = {4}, journal = {Neuropsychologia}, author = {Bartolomeo, P and Siéroff, E and Chokron, S and Decaix, C}, year = {2001}, keywords = {\#nosource, Adult, Aged, Attention, Female, Functional Laterality, Humans, Male, Middle Aged, Perceptual Disorders, Reaction Time, Space Perception, Task Performance and Analysis}, pages = {358--63}, }
@article{bartolomeo_right_2000, title = {[{Right} parietal lesions, spatial neglect and egocentric reference]}, volume = {156}, issn = {00353787}, abstract = {Using a proprioceptive "straight-ahead" pointing task, we determined the position of the subjective sagittal middle in thirty unselected patients with unilateral vascular lesions in the right hemisphere and twenty-two normal controls. Patients with extensive right parietal damage (n = 16) showed an ipsilesional (rightward) deviation of their egocentric reference, whereas patients with lesions that substantially spared the right parietal lobe (n = 14) showed a contralesional (leftward) deviation. No significant correlation emerged between the position of the egocentric reference and the performance on a neglect battery. These results can help explain some dissociations between left neglect signs and ipsilesional deviation of the egocentric reference, and raise some questions about the links among lesion location, neglect signs and egocentric frame of reference.}, number = {2}, journal = {Revue neurologique}, author = {Bartolomeo, P and Chokron, S and Degos, J D}, month = feb, year = {2000}, keywords = {\#nosource, Aged, Agnosia, Brain Ischemia, Cerebral Hemorrhage, Female, Functional Laterality, Humans, Male, Middle Aged, Parietal Lobe, Reference Values, Space Perception, ⛔ No DOI found}, pages = {139--43}, }
@article{bartolomeo_orienting_2000, title = {Orienting of attention in unilateral neglect}, number = {Supplement to Number 4}, journal = {Neurological Sciences}, author = {Bartolomeo, P.}, year = {2000}, keywords = {\#nosource, ⛔ No DOI found}, pages = {S132}, }
@article{bartolomeo_lesions_2000, title = {Lésions pariétales droites, négligence spatiale et référentiel égocentrique [{Right} parietal lesions, unilateral neglect and egocentric reference]}, volume = {156}, abstract = {Using a proprioceptive "straight-ahead" pointing task, we determined the position of the subjective sagittal middle in thirty unselected patients with unilateral vascular lesions in the right hemisphere and twenty-two normal controls. Patients with extensive right parietal damage (n=16) showed an ipsilesional (rightward) deviation of their egocentric reference, whereas patients with lesions that substantially spared the right parietal lobe (n=14) showed a contralesional (leftward) deviation. No significant correlation emerged between the position of the egocentric reference and the performance on a neglect battery. These results can help explain some dissociations between left neglect signs and ipsilesional deviation of the egocentric reference, and raise some questions about the links among lesion location, neglect signs and egocentric frame of reference.}, number = {2}, journal = {Revue Neurologique}, author = {Bartolomeo, P. and Chokron, S. and Degos, J.-D.}, year = {2000}, keywords = {\#nosource, ⛔ No DOI found}, pages = {139--143}, }
@article{bartolomeo_inhibition_1999, title = {Inhibition de retour et négligence spatiale unilatérale}, volume = {9}, number = {4}, journal = {Revue de Neuropsychologie}, author = {Bartolomeo, P. and Chokron, S. and Siéroff, E.}, year = {1999}, keywords = {\#nosource, ⛔ No DOI found}, pages = {420}, }
@article{chokron_pointing_1999, title = {Pointing straight-ahead: {Reversed} patterns of performance in right brain-damaged patients with or without extensive parietal lesion}, volume = {40}, journal = {Brain and Cognition}, author = {Chokron, S. and Bartolomeo, P.}, year = {1999}, keywords = {\#nosource, neglect, egocentric frame of reference, ⛔ No DOI found}, pages = {79--84}, }
@article{chokron_reduire_1999, title = {Réduire expérimentalement la négligence spatiale unilatérale : revue de la littérature et implications théoriques}, volume = {9}, number = {2-3}, journal = {Revue de Neuropsychologie}, author = {Chokron, S. and Bartolomeo, P.}, year = {1999}, keywords = {\#nosource, neglect, egocentric frame of reference, ⛔ No DOI found}, pages = {129--165}, }
@article{decaix_heminegligence_1999, title = {L'héminégligence : biais de l'orientation exogène ou endogène de l'attention?}, volume = {9}, number = {4}, journal = {Revue de Neuropsychologie}, author = {Decaix, C. and Bartolomeo, P. and Chokron, S. and Siéroff, E.}, year = {1999}, keywords = {\#nosource, ⛔ No DOI found}, pages = {431--432}, }
@article{bartolomeo_left_1999, title = {Left unilateral neglect or right hyperattention?}, volume = {53}, issn = {00283878}, doi = {10.1212/wnl.53.9.2023}, abstract = {BACKGROUND: Contradictory interpretations of left unilateral neglect suggest that it reflects either decreased attention toward the left or increased attention toward the right. According to the right-hyperattention postulate, increasing severity of neglect should result from an increasingly stronger bias toward the right. Thus, response times to right-sided targets should become progressively faster as neglect increases in severity across patients. The left-hypoattention postulate predicts that as neglect increases, progressively less-attentional resources are deployed in both hemispaces. Thus, response times to right targets should progressively increase with increasing neglect. METHODS: We analyzed the distribution of manual response times to left- and right-sided targets in 24 patients with right hemisphere lesions and varying degrees of left neglect. RESULTS: Not only the responses to left targets but also those to right targets became progressively slower as neglect increased, consistent with the hypoattention account. However, the two regression lines were not parallel. With increasing neglect, responses to left targets increased more steeply than those to right targets did. CONCLUSIONS: A rightward attentional bias is present in patients with left neglect, together with left hypoattention. However, this rightward bias is one of defective, and not enhanced, attention.}, number = {9}, journal = {Neurology}, author = {Bartolomeo, P and Chokron, S}, month = dec, year = {1999}, keywords = {\#nosource, Aged, Aged, 80 and over, Attention, Brain Damage, Chronic, Dominance, Cerebral, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Orientation, Perceptual Disorders, Psychomotor Performance, Reaction Time}, pages = {2023--7}, }
@article{bartolomeo_heminegligence_1998, title = {L'héminégligence spatiale de la perception à l'action [{Spatial} hemineglect between perception and action]}, volume = {8}, abstract = {Spatial hemineglect is characterised by the reduction of responses to stimuli presented to the side opposite a brain lesion. Mechanisms operating upon various stages ranging from perception to action have been invoked to explain neglect. Evidence concerning some of these possible levels of impairment is reviewed. It is concluded that the interaction of a number of attentional deficits, mainly operating upon a visual-perceptual frame of reference, is the most plausible explanation of neglect phenomena.}, number = {1}, journal = {Revue de Neuropsychologie}, author = {Bartolomeo, P.}, year = {1998}, keywords = {\#nosource, neglect, ⛔ No DOI found}, pages = {83--99}, }
@article{bartolomeo_unilateral_1998, title = {Unilateral neglect: {From} perception to action}, volume = {10}, number = {Suppl. 10}, journal = {European Journal of Neuroscience}, author = {Bartolomeo, P.}, year = {1998}, keywords = {\#nosource, ⛔ No DOI found}, pages = {432}, }
@article{bartolomeo_leffet_1998, title = {L’effet des lésions pariétales droites sur la position de la référence égocentrique}, volume = {154}, number = {Suppl. 1}, journal = {Revue Neurologique}, author = {Bartolomeo, P. and Chokron, S. and Degos, J.-D.}, year = {1998}, keywords = {\#nosource, ⛔ No DOI found}, pages = {93}, }
@article{dalla_barba_conoscenza_1998, title = {Conoscenza implicita e anosognosia: verso una neuropsicologia della coscienza [{Toward} a neuropsychology of consciousness: implicit knowledge and anosognosia]}, volume = {59}, number = {6}, journal = {Archivio di Psicologia, Neurologia e Psichiatria}, author = {Dalla Barba, G. and Bartolomeo, P.}, year = {1998}, keywords = {\#nosource, ⛔ No DOI found}, pages = {644--678}, }
@article{dalla_barba_conscience_1998, title = {Conscience d'anosognosie}, volume = {154}, number = {Suppl. 1}, journal = {Revue Neurologique}, author = {Dalla Barba, G. and Bartolomeo, P. and Ergis, A.M. and Boissé, M.F. and Bachoud-Lévi, A.C.}, year = {1998}, keywords = {\#nosource, ⛔ No DOI found}, pages = {95}, }
@article{bartolomeo_disruption_1998, title = {Disruption of residual reading capacity in a pure alexic patient after a mirror-image right-hemispheric lesion}, volume = {50}, issn = {00283878}, doi = {10.1212/wnl.50.1.286}, abstract = {A 74-year-old woman became a letter-by-letter reader after the occurrence of a left occipito-temporal hematoma. Seven months later, she suffered a second, mirror-image hematoma in the right hemisphere. After this second lesion, her residual reading capacity deteriorated dramatically in terms of both accuracy and reading latencies for words and isolated letters. Our findings support the hypothesis that the right hemisphere contributes to the residual reading capacities of pure alexic patients.}, number = {1}, journal = {Neurology}, author = {Bartolomeo, P and Bachoud-Lévi, A C and Degos, J D and Boller, F}, month = jan, year = {1998}, keywords = {\#nosource, Aged, Cerebral Cortex, Dominance, Cerebral, Dyslexia, Acquired, Female, Hematoma, Humans, Magnetic Resonance Imaging, PURE ALEXIA, Reading}, pages = {286--8}, }
@article{chokron_patterns_1997, title = {Patterns of dissociation between left hemineglect and deviation of the egocentric reference}, volume = {35}, issn = {00283932}, doi = {10.1016/s0028-3932(97)00079-1}, abstract = {Sixteen control subjects and six right brain-damaged patients with left hemiparesis (three showing signs of left unilateral neglect, three with no signs of neglect) performed a straight-ahead pointing task with their right hand while blindfolded. The aim was to test the hypothesis that the egocentric reference shows significant ipsilesional deviation in left neglect patients. We found no correlation between the position of the egocentric reference and the presence of neglect signs. Neglect patients, like non-neglect patients, showed leftward, rightward or no significant deviation when pointing straight ahead. Results are discussed with reference to egocentric hypotheses of neglect and experimental remission of neglect.}, number = {11}, journal = {Neuropsychologia}, author = {Chokron, S and Bartolomeo, P}, month = nov, year = {1997}, keywords = {\#nosource, Adult, Attention, Brain, Female, Functional Laterality, Humans, Male, Orientation, Space Perception, neglect}, pages = {1503--8}, }
@article{bartolomeo_relationship_1994, title = {The relationship between visuospatial and representational neglect}, volume = {44}, issn = {00283878}, doi = {10.1212/wnl.44.9.1710}, abstract = {Using a quantitative measure, we analyzed the relationship between visuospatial and representational neglect in right- and left-brain-damaged patients and found signs of representational neglect only in right-brain-damaged patients. Although representational neglect was always associated with visuospatial neglect, suggesting that the two forms share a common underlying mechanism, the most frequent finding in right-brain--damaged patients was that of visuospatial neglect in isolation. A strong influence of the phenomenon of attentional attraction toward space ipsilateral to the lesion in visuospatial, as opposed to imaginal, tasks can account for this finding.}, number = {9}, journal = {Neurology}, author = {Bartolomeo, P and D'Erme, P and Gainotti, G}, year = {1994}, keywords = {\#nosource, Attention, Brain Damage, Chronic, Dominance, Cerebral, Humans, Spatial Behavior, Visual Perception, neglect, representational, imaginal, visuospatial, mental imagery}, pages = {1710--4}, }
@article{bartolomeo_incidenza_1992, title = {Incidenza dell'emi-negligenza in corso di compiti rappresentativi e visuo-percettivi in pazienti cerebrolesi [{Incidence} of hemi-neglect in representational and visuoperceptual tasks performed by brain damaged patients]}, volume = {53}, number = {2}, journal = {Archivio di Psicologia, Neurologia e Psichiatria}, author = {Bartolomeo, P. and D'Erme, P. and Gainotti, G.}, year = {1992}, keywords = {\#nosource, neglect, representational, imaginal, visuospatial, mental imagery, ⛔ No DOI found}, pages = {165--189}, }
@article{mcculloch_heterarchy_1945, title = {A heterarchy of values determined by the topology of nervous nets}, volume = {7}, issn = {0007-4985, 1522-9602}, url = {http://link.springer.com/10.1007/BF02478457}, doi = {10.1007/BF02478457}, language = {en}, number = {2}, urldate = {2024-02-06}, journal = {The Bulletin of Mathematical Biophysics}, author = {McCulloch, Warren S.}, month = jun, year = {1945}, pages = {89--93}, }