@article{
 title = {Global environmental change effects on plant community composition trajectories depend upon management legacies},
 type = {article},
 year = {2018},
 keywords = {biodiversity change,climate change,disturbance regime,forestREplot,herbaceous layer,management intensity,nitrogen deposition,plant functional traits,time lag,vegetation resurvey},
 pages = {1722-1740},
 volume = {24},
 id = {e9723505-543a-3d8d-9bdc-d29463399448},
 created = {2018-06-28T07:31:32.479Z},
 file_attached = {true},
 profile_id = {59400480-ddb0-3b57-bdd5-1de3f53a15c5},
 last_modified = {2021-09-24T15:23:40.822Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {Introduction: D-dimer assay, generally evaluated according to cutoff points calibrated for VTE exclusion, is used to estimate the individual risk of recurrence after a first idiopathic event of venous thromboembolism (VTE). Methods: Commercial D-dimer assays, evaluated according to predetermined cutoff levels for each assay, specific for age (lower in subjects <70 years) and gender (lower in males), were used in the recent DULCIS study. The present analysis compared the results obtained in the DULCIS with those that might have been had using the following different cutoff criteria: traditional cutoff for VTE exclusion, higher levels in subjects aged ≥60 years, or age multiplied by 10. Results: In young subjects, the DULCIS low cutoff levels resulted in half the recurrent events that would have occurred using the other criteria. In elderly patients, the DULCIS results were similar to those calculated for the two age-adjusted criteria. The adoption of traditional VTE exclusion criteria would have led to positive results in the large majority of elderly subjects, without a significant reduction in the rate of recurrent event. Conclusion: The results confirm the usefulness of the cutoff levels used in DULCIS.},
 bibtype = {article},
 author = {Perring, Michael P. and Bernhardt-Römermann, Markus and Baeten, Lander and Midolo, Gabriele and Blondeel, Haben and Depauw, Leen and Landuyt, Dries and Maes, Sybryn L. and De Lombaerde, Emiel and Carón, Maria Mercedes and Vellend, Mark and Brunet, Jörg and Chudomelová, Markéta and Decocq, Guillaume and Diekmann, Martin and Dirnböck, Thomas and Dörfler, Inken and Durak, Tomasz and De Frenne, Pieter and Gilliam, Frank S. and Hédl, Radim and Heinken, Thilo and Hommel, Patrick and Jaroszewicz, Bogdan and Kirby, Keith J. and Kopecký, Martin and Lenoir, Jonathan and Li, Daijiang and Máliš, František and Mitchell, Fraser J.G. and Naaf, Tobias and Newman, Miles and Petřík, Petr and Reczyńska, Kamila and Schmidt, Wolfgang and Standovár, Tibor and Świerkosz, Krzysztof and Van Calster, Hans and Vild, Ondřej and Wagner, Eva Rosa and Wulf, Monika and Verheyen, Kris},
 doi = {10.1111/gcb.14030},
 journal = {Global Change Biology},
 number = {4}
}

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Methods: Commercial D-dimer assays, evaluated according to predetermined cutoff levels for each assay, specific for age (lower in subjects <70 years) and gender (lower in males), were used in the recent DULCIS study. The present analysis compared the results obtained in the DULCIS with those that might have been had using the following different cutoff criteria: traditional cutoff for VTE exclusion, higher levels in subjects aged ≥60 years, or age multiplied by 10. Results: In young subjects, the DULCIS low cutoff levels resulted in half the recurrent events that would have occurred using the other criteria. In elderly patients, the DULCIS results were similar to those calculated for the two age-adjusted criteria. The adoption of traditional VTE exclusion criteria would have led to positive results in the large majority of elderly subjects, without a significant reduction in the rate of recurrent event. Conclusion: The results confirm the usefulness of the cutoff levels used in DULCIS.","bibtype":"article","author":"Perring, Michael P. and Bernhardt-Römermann, Markus and Baeten, Lander and Midolo, Gabriele and Blondeel, Haben and Depauw, Leen and Landuyt, Dries and Maes, Sybryn L. and De Lombaerde, Emiel and Carón, Maria Mercedes and Vellend, Mark and Brunet, Jörg and Chudomelová, Markéta and Decocq, Guillaume and Diekmann, Martin and Dirnböck, Thomas and Dörfler, Inken and Durak, Tomasz and De Frenne, Pieter and Gilliam, Frank S. and Hédl, Radim and Heinken, Thilo and Hommel, Patrick and Jaroszewicz, Bogdan and Kirby, Keith J. and Kopecký, Martin and Lenoir, Jonathan and Li, Daijiang and Máliš, František and Mitchell, Fraser J.G. and Naaf, Tobias and Newman, Miles and Petřík, Petr and Reczyńska, Kamila and Schmidt, Wolfgang and Standovár, Tibor and Świerkosz, Krzysztof and Van Calster, Hans and Vild, Ondřej and Wagner, Eva Rosa and Wulf, Monika and Verheyen, Kris","doi":"10.1111/gcb.14030","journal":"Global Change Biology","number":"4","bibtex":"@article{\n title = {Global environmental change effects on plant community composition trajectories depend upon management legacies},\n type = {article},\n year = {2018},\n keywords = {biodiversity change,climate change,disturbance regime,forestREplot,herbaceous layer,management intensity,nitrogen deposition,plant functional traits,time lag,vegetation resurvey},\n pages = {1722-1740},\n volume = {24},\n id = {e9723505-543a-3d8d-9bdc-d29463399448},\n created = {2018-06-28T07:31:32.479Z},\n file_attached = {true},\n profile_id = {59400480-ddb0-3b57-bdd5-1de3f53a15c5},\n last_modified = {2021-09-24T15:23:40.822Z},\n read = {true},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n private_publication = {false},\n abstract = {Introduction: D-dimer assay, generally evaluated according to cutoff points calibrated for VTE exclusion, is used to estimate the individual risk of recurrence after a first idiopathic event of venous thromboembolism (VTE). Methods: Commercial D-dimer assays, evaluated according to predetermined cutoff levels for each assay, specific for age (lower in subjects <70 years) and gender (lower in males), were used in the recent DULCIS study. The present analysis compared the results obtained in the DULCIS with those that might have been had using the following different cutoff criteria: traditional cutoff for VTE exclusion, higher levels in subjects aged ≥60 years, or age multiplied by 10. Results: In young subjects, the DULCIS low cutoff levels resulted in half the recurrent events that would have occurred using the other criteria. In elderly patients, the DULCIS results were similar to those calculated for the two age-adjusted criteria. The adoption of traditional VTE exclusion criteria would have led to positive results in the large majority of elderly subjects, without a significant reduction in the rate of recurrent event. 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