Discovery and Structure of a Potent and Highly Specific Blocker of Insect Calcium Channels. Wang, X., Connor, M., Wilson, D., Wilson, H., Nicholson, G., Smith, R., Shaw, D., Mackay, J., Alewood, P., Christie, M., Christie, M., & King, G. Journal of Biological Chemistry, 276(43):40306-40312, 2001. doi abstract bibtex We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with ω-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.
@article{
title = {Discovery and Structure of a Potent and Highly Specific Blocker of Insect Calcium Channels},
type = {article},
year = {2001},
pages = {40306-40312},
volume = {276},
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last_modified = {2023-01-10T01:46:33.265Z},
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abstract = {We have isolated a novel family of insect-selective neurotoxins that appear to be the most potent blockers of insect voltage-gated calcium channels reported to date. These toxins display exceptional phylogenetic specificity, with at least a 10,000-fold preference for insect versus vertebrate calcium channels. The structure of one of the toxins reveals a highly structured, disulfide-rich core and a structurally disordered C-terminal extension that is essential for channel blocking activity. Weak structural/functional homology with ω-agatoxin-IVA/B, the prototypic inhibitor of vertebrate P-type calcium channels, suggests that these two toxin families might share a similar mechanism of action despite their vastly different phylogenetic specificities.},
bibtype = {article},
author = {Wang, X.-H. and Connor, M. and Wilson, D. and Wilson, H.I. and Nicholson, G.M. and Smith, R. and Shaw, D. and Mackay, J.P. and Alewood, P.F. and Christie, M.J. and Christie, M.J. and King, G.F.},
doi = {10.1074/jbc.M105206200},
journal = {Journal of Biological Chemistry},
number = {43}
}
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