@article{
 title = {Ikaros: A key regulator of haematopoiesis},
 type = {article},
 year = {2002},
 pages = {1304-1307},
 volume = {34},
 id = {b11bff38-f90a-3ab1-9e2f-59aa100f8266},
 created = {2023-01-10T01:46:24.702Z},
 file_attached = {false},
 profile_id = {a5a2ab6f-a8b5-3db6-97bc-618752ee4386},
 group_id = {bc1ab1d4-9e57-37e6-9fb5-435fca0ee9d2},
 last_modified = {2023-01-10T01:46:24.702Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {Ikaros is an essential transcription factor for normal lymphocyte development. Because of its interaction with a number of closely related factors, Ikaros is required for correct regulation of differentiation and cell proliferation in T- and B-cell lineages. Interestingly, Ikaros appears to function both as a transcriptional repressor and as an activator through its ability to bind a large number of nuclear factors, including components of both histone deacetylase and ATP-dependent chromatin remodelling complexes. In addition, nuclear localisation is important for Ikaros function - unlike most transcription factors, Ikaros is localised to discrete nuclear foci in lymphoid cells, suggesting it employs novel mechanisms to regulate transcription. © 2002 Elsevier Science Ltd. All rights reserved.},
 bibtype = {article},
 author = {Westman, B.J. and Mackay, J.P. and Gell, D.},
 doi = {10.1016/S1357-2725(02)00070-5},
 journal = {International Journal of Biochemistry and Cell Biology},
 number = {10}
}

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