@article{
 title = {Memantine hydrochloride: a drug to be repurposed against Chikungunya virus?},
 type = {article},
 year = {2021},
 websites = {https://doi.org/10.1007/s43440-021-00216-4},
 id = {91d06851-f05f-3c1d-bcf2-478af8ce5abc},
 created = {2021-02-03T17:38:42.042Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2021-02-03T17:38:42.042Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Pereira2021},
 source_type = {JOUR},
 private_publication = {false},
 abstract = {Chikungunya fever is an endemic disease caused by the Chikungunya virus (CHIKV) to which there is no vaccine or effective antiviral drug treatment so far. Our study aimed to evaluate the potential anti-CHIKV activity of memantine hydrochloride (mtnH), a drug from the class of the aminoadamantanes approved for the treatment of Alzheimer´s disease, as a possible drug to be repurposed to the treatment of Chikungunya fever.},
 bibtype = {article},
 author = {Pereira, Anna Karla dos Santos and Santos, Igor A and da Silva, Washington W and Nogueira, Flávia A Resende and Bergamini, Fernando R G and Jardim, Ana Carolina G and Corbi, Pedro P},
 doi = {10.1007/s43440-021-00216-4},
 journal = {Pharmacological Reports}
}

Chikungunya fever is an endemic disease caused by the Chikungunya virus (CHIKV) to which there is no vaccine or effective antiviral drug treatment so far. Our study aimed to evaluate the potential anti-CHIKV activity of memantine hydrochloride (mtnH), a drug from the class of the aminoadamantanes approved for the treatment of Alzheimer´s disease, as a possible drug to be repurposed to the treatment of Chikungunya fever.

@article{
 title = {Antivirals Against Coronaviruses: Candidate Drugs for SARS-CoV-2 Treatment?},
 type = {article},
 year = {2020},
 volume = {11},
 websites = {https://www.frontiersin.org/article/10.3389/fmicb.2020.01818/full},
 month = {8},
 day = {13},
 id = {a59694bd-81de-3b3e-bb0e-322f6978ea7d},
 created = {2020-08-02T01:28:37.989Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2020-08-13T05:15:20.203Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {Coronaviruses (CoVs) is a group of viruses from family Coronaviridae which can infect human and animals, causing mild to severe diseases. The ongoing pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global threat, urging into the development of new therapeutic strategies. Here we presented a selection of relevant compounds, from 2005 up to now, with in vitro and/or in vivo antiviral activities against human and/or animal CoVs. We also presented compounds that have reached clinical trials, as well as further discuss the potentiality of other molecules towards their application in (re)emergent CoVs outbreaks. Finally, through the rationalization of the data herein presented, we wish to encourage further research encompassing these compounds as potential SARS-CoV-2 drug candidates.},
 bibtype = {article},
 author = {Santos, Igor de Andrade and Grosche, Victória Riquena and Bergamini, Fernando Rodrigues Goulart and Sabino-Silva, Robinson and Jardim, Ana Carolina Gomes},
 doi = {10.3389/fmicb.2020.01818},
 journal = {Frontiers in Microbiology}
}

Coronaviruses (CoVs) is a group of viruses from family Coronaviridae which can infect human and animals, causing mild to severe diseases. The ongoing pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a global threat, urging into the development of new therapeutic strategies. Here we presented a selection of relevant compounds, from 2005 up to now, with in vitro and/or in vivo antiviral activities against human and/or animal CoVs. We also presented compounds that have reached clinical trials, as well as further discuss the potentiality of other molecules towards their application in (re)emergent CoVs outbreaks. Finally, through the rationalization of the data herein presented, we wish to encourage further research encompassing these compounds as potential SARS-CoV-2 drug candidates.

@article{
 title = {What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks},
 type = {article},
 year = {2020},
 websites = {http://pubs.rsc.org/en/Content/ArticleLanding/2020/DT/D0DT02478C},
 id = {a3a7afdd-6415-3ffd-a070-29a01461673b},
 created = {2020-09-03T15:45:31.803Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2020-09-03T15:45:31.803Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {In light of the Covid-19 outbreak, this review brings the historical and current literature efforts towards the development of antiviral metallodrugs. Classical compounds such as CTC-96 and auranofin are discussed...},
 bibtype = {article},
 author = {de Paiva, Raphael EF and Neto, Antônio Marçal and Santos, Igor A. and Jardim, Ana Carolina Gomes and Corbi, Pedro Paulo and Bergamini, Fernando Rodrigues Goulart},
 doi = {10.1039/D0DT02478C},
 journal = {Dalton Transactions}
}

In light of the Covid-19 outbreak, this review brings the historical and current literature efforts towards the development of antiviral metallodrugs. Classical compounds such as CTC-96 and auranofin are discussed...

@article{
 title = {Polynuclear copper(II) complexes with nalidixic acid hydrazones: Antiproliferative activity and selectivity assessment over a panel of tumor cells},
 type = {article},
 year = {2019},
 pages = {491-502},
 volume = {484},
 websites = {https://linkinghub.elsevier.com/retrieve/pii/S0020169318307072},
 month = {1},
 id = {b8d0415a-a0eb-3d8f-b5ee-aef2f08e3896},
 created = {2018-11-20T19:37:19.838Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-11-20T19:37:19.838Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 bibtype = {article},
 author = {Bergamini, Fernando R.G. and Nunes, Julia H.B. and de Carvalho, Marcos A. and Ribeiro, Marcos A. and de Paiva, Paula P. and Banzato, Thais P. and Ruiz, Ana L.T.G. and de Carvalho, João E. and Lustri, Wilton R. and Martins, Daniel O.T.A. and da Costa Ferreira, Ana M. and Corbi, Pedro P.},
 doi = {10.1016/j.ica.2018.09.084},
 journal = {Inorganica Chimica Acta}
}

@article{
 title = {A new palladium ( II ) complex with ibuprofen : Spectroscopic characterization , DFT studies , antibacterial activities and interaction with biomolecules},
 type = {article},
 year = {2019},
 pages = {144-154},
 volume = {1186},
 websites = {https://doi.org/10.1016/j.molstruc.2019.03.020},
 publisher = {Elsevier B.V},
 id = {94afeb42-e799-3f9d-9e6c-20c393cbc380},
 created = {2019-03-25T15:12:52.635Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2019-03-25T15:12:52.635Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 bibtype = {article},
 author = {Fiori-duarte, Ana Thereza and Bergamini, Fernando R G and Enoque, Raphael and Paiva, F De and Manzano, Carlos M and Lustri, Wilton R and Corbi, Pedro P},
 doi = {10.1016/j.molstruc.2019.03.020},
 journal = {Journal of Molecular Structure}
}

@article{
 title = {Pt(II) and Pd(II) complexes with ibuprofen hydrazide: Characterization, theoretical calculations, antibacterial and antitumor assays and studies of interaction with CT-DNA},
 type = {article},
 year = {2018},
 pages = {469-479},
 volume = {1154},
 websites = {http://linkinghub.elsevier.com/retrieve/pii/S0022286017314187},
 publisher = {Elsevier B.V.},
 id = {b414120b-d9d2-34f0-a19b-548ab587ba0a},
 created = {2018-07-28T23:28:38.964Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:38.964Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Manzano2018},
 source_type = {article},
 private_publication = {false},
 bibtype = {article},
 author = {Manzano, Carlos M and Bergamini, Fernando R G and Lustri, Wilton R and Ruiz, Ana Lúcia T G and de Oliveira, Ellen C S and Ribeiro, Marcos A and Formiga, André L B and Corbi, Pedro P},
 doi = {10.1016/j.molstruc.2017.10.072},
 journal = {Journal of Molecular Structure},
 number = {Ii}
}

@article{
 title = {Functional protein nanostructures: a chemical toolbox},
 type = {article},
 year = {2018},
 pages = {9069-9105},
 volume = {47},
 websites = {https://pubs.rsc.org/en/content/articlelanding/2018/cs/c8cs00590g#!divAbstract,http://xlink.rsc.org/?DOI=C8CS00590G},
 id = {264067ef-8b09-33eb-bfbd-e6331b6f90ac},
 created = {2018-11-19T22:22:50.569Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2020-08-02T01:28:38.429Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {Functional protein nanostructures hold immense potential for a broad range of applications, e.g. , in material and biomedical sciences. In this article, the development of chemical toolboxes to build precise functional protein nanostructures that go beyond Nature's portfolio and their applications are summarized.},
 bibtype = {article},
 author = {Kuan, Seah Ling and Bergamini, Fernando Rodrigues Goulart and Weil, Tanja},
 doi = {10.1039/C8CS00590G},
 journal = {Chemical Society Reviews},
 number = {24}
}

Functional protein nanostructures hold immense potential for a broad range of applications, e.g. , in material and biomedical sciences. In this article, the development of chemical toolboxes to build precise functional protein nanostructures that go beyond Nature's portfolio and their applications are summarized.

@article{
 title = {N , N ′, N ′′ versus N , N ′, O imine-containing coordination motifs: ligand-directed synthesis of mononuclear and binuclear Cu II compounds},
 type = {article},
 year = {2017},
 pages = {1563-1567},
 volume = {73},
 websites = {http://scripts.iucr.org/cgi-bin/paper?S2056989017013652},
 month = {10},
 day = {1},
 id = {3274c785-c915-3a5a-a080-2d6a80fd6da5},
 created = {2018-07-28T23:28:37.030Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:37.030Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {FerrazdePaiva2017},
 private_publication = {false},
 abstract = {It is demonstrated here that tridentate imine ligands can control the nuclearity of copper(II) complexes based on the donor atoms present in the ligand. The N , N ′, N ′′-donating imine ligand led to a mononuclear compound, namely dichlorido[ N , N -dimethyl- N ′-(pyridin-2-ylmethylidene)ethane-1,2-diamine]copper(II) monohydrate, [CuCl 2 (C 10 H 15 N 3 )]·H 2 O, 1 , while the N , N ′, O -donating imine ligand produced a binuclear metal complex, namely μ 2 -chlorido-dichlorido(μ 2 -2-[2-(dimethylamino)ethyl]iminomethylphenolato)( N , N -dimethylethylenediamine)dicopper(II) 0.11-hydrate, [Cu 2 (C 11 H 15 N 2 O)Cl 3 (C 4 H 12 N 2 )]·0.11H 2 O, 2 . The structure of 2 is a remarkable example of a binuclear copper(II) complex containing a single substituted 2-iminomethylphenolate ligand that has two copper(II) sites in square-pyramidal coordination.},
 bibtype = {article},
 author = {Ferraz de Paiva, Raphael Enoque and Nakahata, Douglas Hideki and Carvalho, Marcos Alberto de and Rodrigues Goulart Bergamini, Fernando and Corbi, Pedro Paulo},
 doi = {10.1107/S2056989017013652},
 journal = {Acta Crystallographica Section E Crystallographic Communications},
 number = {10}
}

It is demonstrated here that tridentate imine ligands can control the nuclearity of copper(II) complexes based on the donor atoms present in the ligand. The N , N ′, N ′′-donating imine ligand led to a mononuclear compound, namely dichlorido[ N , N -dimethyl- N ′-(pyridin-2-ylmethylidene)ethane-1,2-diamine]copper(II) monohydrate, [CuCl 2 (C 10 H 15 N 3 )]·H 2 O, 1 , while the N , N ′, O -donating imine ligand produced a binuclear metal complex, namely μ 2 -chlorido-dichlorido(μ 2 -2-[2-(dimethylamino)ethyl]iminomethylphenolato)( N , N -dimethylethylenediamine)dicopper(II) 0.11-hydrate, [Cu 2 (C 11 H 15 N 2 O)Cl 3 (C 4 H 12 N 2 )]·0.11H 2 O, 2 . The structure of 2 is a remarkable example of a binuclear copper(II) complex containing a single substituted 2-iminomethylphenolate ligand that has two copper(II) sites in square-pyramidal coordination.

@article{
 title = {Synthesis, characterization and in vitro biological assays of a silver(I) complex with 5-fluorouracil: A strategy to overcome multidrug resistant tumor cells},
 type = {article},
 year = {2017},
 pages = {93-101},
 volume = {195},
 websites = {http://linkinghub.elsevier.com/retrieve/pii/S0022113916304894},
 month = {3},
 id = {bcd56515-777e-359c-b783-4ccc1fd94633},
 created = {2018-07-28T23:28:38.985Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:38.985Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Nunes2017},
 private_publication = {false},
 bibtype = {article},
 author = {Nunes, Julia H. Bormio and Bergamini, Fernando R.G. and Lustri, Wilton R. and de Paiva, Paula P. and Ruiz, Ana Lúcia T.G. and de Carvalho, João Ernesto and Corbi, Pedro P.},
 doi = {10.1016/j.jfluchem.2017.01.016},
 journal = {Journal of Fluorine Chemistry}
}

@article{
 title = {A novel binuclear copper complex incorporating a nalidixic acid derivative displaying a one-dimensional coordination polymeric structure},
 type = {article},
 year = {2016},
 keywords = {binuclear complex,carbonyl hydra-,computational chemistry,coordi-,crystal structure,dft,ii,nalidixic acid,nation polymer,one-dimensional copper,zone},
 volume = {72},
 websites = {http://scripts.iucr.org/cgi-bin/paper?S2053229616008913},
 publisher = {International Union of Crystallography},
 id = {5aa3dea8-c49f-3f5d-8422-b25f93943dc7},
 created = {2018-07-28T23:28:37.695Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:37.695Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bergamini2016a},
 source_type = {article},
 private_publication = {false},
 abstract = {<p>The identification of the antibacterial action of nalidixic acid (nx) was central to the development of the quinolone antibacterial compounds. The ability of the nx naphthyridyl ring to interact with and inhibit some proteins has encouraged the investigation of similar structures in the search for more active compounds with less adverse effects. The possibility of structural modification by attachment of other biologically active moieties to the naphthyridyl ring of nx allowed the development of new active antimicrobial molecules. Hydrazone derivatives of nx can be synthesized easily based on the condensation of the hydrazide derivative of nx with the desired aldehyde or ketone. Only a few complexes with nx hydrazone derivatives have been described but for none were the crystal structures elucidated. The synthesis of a new one-dimensional Cu <sup>II</sup>coordination polymer, namely <italic>catena</italic>-poly[[copper(II)-di-$μ$-chlorido-copper(II)-$μ$-1-ethyl- <italic>N</italic>′-[(1 <italic>H</italic>-imidazol-4-yl)methylidene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazidato-[dimethanolcopper(II)]-$μ$-1-ethyl- <italic>N</italic>′-[(1 <italic>H</italic>-imidazol-3-yl)methylidene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazidato] dichloride methanol tetrasolvate], [Cu <sub>3</sub>(C <sub>16</sub>H <sub>15</sub>N <sub>6</sub>O <sub>2</sub>) <sub>2</sub>Cl <sub>2</sub>(CH <sub>3</sub>OH) <sub>2</sub>]Cl <sub>2</sub>·4CH <sub>3</sub>OH <sub><italic>n</italic></sub>, with the (1 <italic>H</italic>-imidazol-4-yl)methylidene carbohydrazide derivative of nalidixic acid (denoted h4imi), is presented and its structure is compared to the density functional theory (DFT) optimized structure of free h4imi. The title structure presents an octahedral Cu <sup>II</sup>ion on an inversion centre alternating along a polymer chain with a square-pyramidal Cu <sup>II</sup>ion, with the two Cu <sup>II</sup>centres bridged by two chloride ligands. Hydrogen bonds involving chloride counter-ions and methanol solvent molecules mediate the three-dimensional packing of the polymer. Comparison of the geometrical results from the structure analysis with those derived from a DFT study of the free ligand reveal the differences that arise upon coordination. </p>},
 bibtype = {article},
 author = {Bergamini, F R G and Ribeiro, M A and Miranda, P C M L and Formiga, A L B and Corbi, P P},
 doi = {10.1107/S2053229616008913},
 journal = {Acta Crystallographica Section C Structural Chemistry},
 number = {7}
}

The identification of the antibacterial action of nalidixic acid (nx) was central to the development of the quinolone antibacterial compounds. The ability of the nx naphthyridyl ring to interact with and inhibit some proteins has encouraged the investigation of similar structures in the search for more active compounds with less adverse effects. The possibility of structural modification by attachment of other biologically active moieties to the naphthyridyl ring of nx allowed the development of new active antimicrobial molecules. Hydrazone derivatives of nx can be synthesized easily based on the condensation of the hydrazide derivative of nx with the desired aldehyde or ketone. Only a few complexes with nx hydrazone derivatives have been described but for none were the crystal structures elucidated. The synthesis of a new one-dimensional Cu ^IIcoordination polymer, namely catena-poly[[copper(II)-di-$μ$-chlorido-copper(II)-$μ$-1-ethyl- N′-[(1 H-imidazol-4-yl)methylidene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazidato-[dimethanolcopper(II)]-$μ$-1-ethyl- N′-[(1 H-imidazol-3-yl)methylidene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazidato] dichloride methanol tetrasolvate], [Cu ₃(C ₁₆H ₁₅N ₆O ₂) ₂Cl ₂(CH ₃OH) ₂]Cl ₂·4CH ₃OH _n, with the (1 H-imidazol-4-yl)methylidene carbohydrazide derivative of nalidixic acid (denoted h4imi), is presented and its structure is compared to the density functional theory (DFT) optimized structure of free h4imi. The title structure presents an octahedral Cu ^IIion on an inversion centre alternating along a polymer chain with a square-pyramidal Cu ^IIion, with the two Cu ^IIcentres bridged by two chloride ligands. Hydrogen bonds involving chloride counter-ions and methanol solvent molecules mediate the three-dimensional packing of the polymer. Comparison of the geometrical results from the structure analysis with those derived from a DFT study of the free ligand reveal the differences that arise upon coordination.

@article{
 title = {Synthesis, spectroscopic characterizations, crystal structures and DFT studies of nalidixic acid carbonyl hydrazones derivatives},
 type = {article},
 year = {2016},
 keywords = {Carbonyl hydrazones,Crystal struc,[Antimicrobial},
 pages = {115-124},
 volume = {1120},
 websites = {http://linkinghub.elsevier.com/retrieve/pii/S0022286016304719},
 id = {fd857a7b-1d3c-3c78-bc39-43208e03ecdc},
 created = {2018-07-28T23:28:37.709Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:37.709Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bergamini2016},
 source_type = {article},
 private_publication = {false},
 abstract = {©2016 Elsevier B.V. All rights reserved.This article describes the synthesis and characterization of the 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide (hzd) and six carbonyl hydrazones derivatives of the nalidixic with 1H-pyrrol-2-ylmethylidene (hpyrr), 1H-imidazol-2-ylmethylidene (h2imi), pyridin-2-ylmethylidene (h2py), pyridin-3-ylmethylidene (h3py), pyridin-4-ylmethylidene(h4py) and (2-hydroxyphenyl)methylidene (hsali). The carbonyl hydrazones were characterized by elemental and ESI-QTOF-MS analyses, IR and detailed NMR spectroscopic measurements. The 2D NMR experiments allowed the unambiguous assignment of the hydrogen, carbon and nitrogen atoms, which have not been reported for nalidixic acid carbonyl hydrazone derivatives so far. Crystal structures of hzd and the new carbonyl hydrazones h2imi, hpyrr and h3py were determined by X-ray diffraction studies. Although the synthesis of hzd was reported decades ago, the hzd crystal structure have not been reported yet. Geometric optimizations of all the characterized structures were performed with the aid of DFT studies. Despite the fact that the hydrazones with 2-pyridine carboxylic acid (h2py) and salicyl aldehyde (hsali) were already reported by literature, a detailed spectroscopic study followed by DFT studies are also reported for such compounds in this manuscript. Antimicrobial studies of the compounds are also presented.},
 bibtype = {article},
 author = {Bergamini, F R G and Ribeiro, M A and Lancellotti, M and Machado, D and Miranda, P.C.M.L. and Cuin, A and Formiga, A L B and Corbi, P P},
 doi = {10.1016/j.molstruc.2016.05.025},
 journal = {Journal of Molecular Structure}
}

©2016 Elsevier B.V. All rights reserved.This article describes the synthesis and characterization of the 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide (hzd) and six carbonyl hydrazones derivatives of the nalidixic with 1H-pyrrol-2-ylmethylidene (hpyrr), 1H-imidazol-2-ylmethylidene (h2imi), pyridin-2-ylmethylidene (h2py), pyridin-3-ylmethylidene (h3py), pyridin-4-ylmethylidene(h4py) and (2-hydroxyphenyl)methylidene (hsali). The carbonyl hydrazones were characterized by elemental and ESI-QTOF-MS analyses, IR and detailed NMR spectroscopic measurements. The 2D NMR experiments allowed the unambiguous assignment of the hydrogen, carbon and nitrogen atoms, which have not been reported for nalidixic acid carbonyl hydrazone derivatives so far. Crystal structures of hzd and the new carbonyl hydrazones h2imi, hpyrr and h3py were determined by X-ray diffraction studies. Although the synthesis of hzd was reported decades ago, the hzd crystal structure have not been reported yet. Geometric optimizations of all the characterized structures were performed with the aid of DFT studies. Despite the fact that the hydrazones with 2-pyridine carboxylic acid (h2py) and salicyl aldehyde (hsali) were already reported by literature, a detailed spectroscopic study followed by DFT studies are also reported for such compounds in this manuscript. Antimicrobial studies of the compounds are also presented.

@article{
 title = {Synthesis and crystal structure of a palladium(II) complex with the amino acid L-citrulline},
 type = {article},
 year = {2015},
 keywords = {[amino acids,palladium complex,powder diffractio},
 pages = {357-361},
 volume = {30},
 websites = {http://www.journals.cambridge.org/abstract_S0885715615000652},
 id = {d0bb8e3e-5d60-369c-a705-54cc926c9555},
 created = {2018-07-28T23:28:38.354Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:38.354Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Mascaliovas2015},
 source_type = {article},
 private_publication = {false},
 abstract = {Synthesis and structural characterization of a novel palladium Pd(II) complex with the amino acid L-citrulline (Cit, C 6 H 13 N 3 O 3 ) are presented in this paper. Elemental analysis indicates a 1:2 metal/ligand molar composition for the complex, with the molecular formula PdC 12 H 24 N 6 O 6. The compound was also characterized by infrared (IR) spectroscopic measurements and the crystal structure has been solved by powder X-ray diffraction data with simulated annealing strategy in real space. The Pd(II) complex crystallizes in the triclinic system with space group P-1 and cell parameters a = 4.6493(4) Å, b = 5.222(4) Å, c = 18.040(2) Å, $α$ = 77.41(6)°, $β$ = 94.72(7),° and $γ$ = 101.45(7)°. The crystal structure confirms the presence of Pd(II) ions in a nearly square planar environment and the molecular formula with deprotonated citrulline as proposed by analytical and spectroscopic data.},
 bibtype = {article},
 author = {Mascaliovas, Bruno Z and Bergamini, Fernando R G and Cuin, Alexandre and Corbi, Pedro P},
 doi = {10.1017/S0885715615000652},
 journal = {Powder Diffraction},
 number = {04}
}

Synthesis and structural characterization of a novel palladium Pd(II) complex with the amino acid L-citrulline (Cit, C 6 H 13 N 3 O 3 ) are presented in this paper. Elemental analysis indicates a 1:2 metal/ligand molar composition for the complex, with the molecular formula PdC 12 H 24 N 6 O 6. The compound was also characterized by infrared (IR) spectroscopic measurements and the crystal structure has been solved by powder X-ray diffraction data with simulated annealing strategy in real space. The Pd(II) complex crystallizes in the triclinic system with space group P-1 and cell parameters a = 4.6493(4) Å, b = 5.222(4) Å, c = 18.040(2) Å, $α$ = 77.41(6)°, $β$ = 94.72(7),° and $γ$ = 101.45(7)°. The crystal structure confirms the presence of Pd(II) ions in a nearly square planar environment and the molecular formula with deprotonated citrulline as proposed by analytical and spectroscopic data.

@article{
 title = {Investigating the inclusion of the Ag(I)-nimesulide complex into b-cyclodextrin: Studies in solution and in the solid state},
 type = {article},
 year = {2014},
 keywords = {Inclusion chemistry,Nimesulide,[B-Cyclodextrin},
 volume = {79},
 id = {2fcc02fa-cd1b-3fba-afdd-6531b339dc51},
 created = {2018-07-28T23:28:38.061Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:38.061Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {DePaiva2014},
 source_type = {article},
 private_publication = {false},
 abstract = {The present work describes the preparation and characterization of inclusion systems involving b-CD and the silver(I) nimesulide coordination complex (Ag-NMS), prepared by kneading (K) and co-evaporation (CE) methods. Solid state characterization by DSC, XRD and IR vibrational spectroscopic measurements provided remarkable evidences of the formation of true inclusion systems. Solution measurements provided information about the inclusion mode. The UV-Vis spectroscopy was used to obtain the association constants by the Scatchard method, and the value obtained was 370 ± 2 L mol-1. The 1H NMR spectroscopic measurements indicate a total inclusion of the guest into the cavity. A 2D NOESY experiment was carried out for the inclusion complex. The spectrum shows that hydrogens 3-6 of the cyclodextrin clearly correlate with the protons of the phenoxy ring of nimesulide in the Ag-NMS coordination compound, which confirms the formation of the inclusion complex. The antibacterial activities of the Ag-NMS and CE-[(Ag-NMS)b-CD] inclusion system were evaluated by the well diffusion method over Escherichia coli and Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Grampositive) pathogenic bacterial strains. The observed data shows the significant antibacterial activity of the Ag-NMS coordination complex, and no activity for the inclusion complex under the same considered conditions. ©Springer Science+Business Media Dordrecht 2013.},
 bibtype = {article},
 author = {De Paiva, R E F and Abbehausen, C and Bergamini, F R G and Thompson, A L and Alves, D A and Lancellotti, M and Corbi, P P},
 doi = {10.1007/s10847-013-0348-4},
 journal = {Journal of Inclusion Phenomena and Macrocyclic Chemistry},
 number = {1-2}
}

The present work describes the preparation and characterization of inclusion systems involving b-CD and the silver(I) nimesulide coordination complex (Ag-NMS), prepared by kneading (K) and co-evaporation (CE) methods. Solid state characterization by DSC, XRD and IR vibrational spectroscopic measurements provided remarkable evidences of the formation of true inclusion systems. Solution measurements provided information about the inclusion mode. The UV-Vis spectroscopy was used to obtain the association constants by the Scatchard method, and the value obtained was 370 ± 2 L mol-1. The 1H NMR spectroscopic measurements indicate a total inclusion of the guest into the cavity. A 2D NOESY experiment was carried out for the inclusion complex. The spectrum shows that hydrogens 3-6 of the cyclodextrin clearly correlate with the protons of the phenoxy ring of nimesulide in the Ag-NMS coordination compound, which confirms the formation of the inclusion complex. The antibacterial activities of the Ag-NMS and CE-[(Ag-NMS)b-CD] inclusion system were evaluated by the well diffusion method over Escherichia coli and Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Grampositive) pathogenic bacterial strains. The observed data shows the significant antibacterial activity of the Ag-NMS coordination complex, and no activity for the inclusion complex under the same considered conditions. ©Springer Science+Business Media Dordrecht 2013.

@article{
 title = {A silver complex with tryptophan: Synthesis, structural characterization, DFT studies and antibacterial and antitumor assays in vitro},
 type = {article},
 year = {2013},
 pages = {125-131},
 volume = {1031},
 websites = {http://linkinghub.elsevier.com/retrieve/pii/S0022286012007090},
 month = {1},
 id = {60cf33ef-7f9d-331d-a21f-37b19fc4685c},
 created = {2018-07-28T23:28:38.607Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:38.607Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Carvalho2013},
 source_type = {article},
 private_publication = {false},
 abstract = {The synthesis, spectroscopic characterization and biological assays of a new silver(I) complex with L -tryptophan (TRP) are presented. Elemental and thermal analyses and ESI-QTOF mass spectrometric measurements of the solid compound suggest the composition AgC11H11N2O2. Infrared and solid-state NMR analyses indicate coordination of TRP to Ag(I) ion through the nitrogen of the NH 2 group and also through the oxygen of carboxylate group. Theoretical (DFT) calculations permit proposing an optimized geometry for the complex. Antibacterial assays indicated that the Ag-TRP complex is effective against Staphylococcus aureus and Enterococcus faecalis (Gram-positive), and Pseudomonas aeruginosa and Escherichia coli (Gram-negative) bacterial strains. The complex was also cytotoxic against Panc-1 (human pancreatic carcinoma) and SK-Mel 103 (human melanoma) cells.},
 bibtype = {article},
 author = {Carvalho, Marcos A and de Paiva, Raphael E F and Bergamini, Fernando R G and Gomes, Alexandre F and Gozzo, Fábio C and Lustri, Wilton R and Formiga, André L B and Shishido, Silvia M and Ferreira, Carmen V and Corbi, Pedro P},
 doi = {10.1016/j.molstruc.2012.07.044},
 journal = {Journal of Molecular Structure}
}

The synthesis, spectroscopic characterization and biological assays of a new silver(I) complex with L -tryptophan (TRP) are presented. Elemental and thermal analyses and ESI-QTOF mass spectrometric measurements of the solid compound suggest the composition AgC11H11N2O2. Infrared and solid-state NMR analyses indicate coordination of TRP to Ag(I) ion through the nitrogen of the NH 2 group and also through the oxygen of carboxylate group. Theoretical (DFT) calculations permit proposing an optimized geometry for the complex. Antibacterial assays indicated that the Ag-TRP complex is effective against Staphylococcus aureus and Enterococcus faecalis (Gram-positive), and Pseudomonas aeruginosa and Escherichia coli (Gram-negative) bacterial strains. The complex was also cytotoxic against Panc-1 (human pancreatic carcinoma) and SK-Mel 103 (human melanoma) cells.

@article{
 title = {Silver(I) complexes with symmetrical Schiff bases: Synthesis, structural characterization, DFT studies and antimycobacterial assays},
 type = {article},
 year = {2013},
 keywords = {Mycobacterium,Schiff bases,Silver,[Anisaldehyde},
 volume = {62},
 id = {8ad49530-b708-3cb0-b4f8-4598b7265db7},
 created = {2018-07-28T23:28:38.665Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:38.665Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Paiva2013},
 source_type = {article},
 private_publication = {false},
 abstract = {Synthesis, structural and spectroscopic characterizations, molecular modeling and antimycobacterial assays of new silver(I) complexes with two Schiff bases - MBDA and MBDB - are reported. The complexes [Ag(MBDA) 2]NO3, or AgMBDA, and [Ag(MBDB)NO3] or AgMBDB, were obtained by the reaction of the respective ligands with silver(I) nitrate in methanol. The Schiff bases were previously obtained by mixing ethylenediamine or 1,3-diaminopropane with p-anisaldehyde. The characterizations of the complexes were based on elemental (C, H and N) and thermal (TG-DTA) analyses and 13C and 1H NMR and FT-IR spectroscopic measurements, as well as X-ray structure determination for AgMBDA. Spectroscopic data predicted by DFT calculations are in agreement with the experimental data for the AgMBDA complex. The AgMBDA complex has a monomeric structure with a molar proportion 1:2 Ag/ligand, while AgMBDB presents a 1:1 proportion. The complexes AgMBDA and AgMBDB showed to be more effective against Mycobacterium tuberculosis than antibacterial agent silver sulfadiazine - SSD. ©2013 Elsevier Ltd. All rights reserved.},
 bibtype = {article},
 author = {Paiva, I L and De Carvalho, G S G and Da Silva, A D and Corbi, P P and Bergamini, F R G and Formiga, A L B and Diniz, R and Do Carmo, W R and Leite, C Q F and Pavan, F R and Cuin, A},
 doi = {10.1016/j.poly.2013.06.031},
 journal = {Polyhedron}
}

Synthesis, structural and spectroscopic characterizations, molecular modeling and antimycobacterial assays of new silver(I) complexes with two Schiff bases - MBDA and MBDB - are reported. The complexes [Ag(MBDA) 2]NO3, or AgMBDA, and [Ag(MBDB)NO3] or AgMBDB, were obtained by the reaction of the respective ligands with silver(I) nitrate in methanol. The Schiff bases were previously obtained by mixing ethylenediamine or 1,3-diaminopropane with p-anisaldehyde. The characterizations of the complexes were based on elemental (C, H and N) and thermal (TG-DTA) analyses and 13C and 1H NMR and FT-IR spectroscopic measurements, as well as X-ray structure determination for AgMBDA. Spectroscopic data predicted by DFT calculations are in agreement with the experimental data for the AgMBDA complex. The AgMBDA complex has a monomeric structure with a molar proportion 1:2 Ag/ligand, while AgMBDB presents a 1:1 proportion. The complexes AgMBDA and AgMBDB showed to be more effective against Mycobacterium tuberculosis than antibacterial agent silver sulfadiazine - SSD. ©2013 Elsevier Ltd. All rights reserved.

@article{
 title = {Synthesis, spectroscopic characterization, DFT studies, and initial antibacterial assays in vitro of a new palladium(II) complex with tryptophan},
 type = {article},
 year = {2012},
 pages = {1700-1711},
 volume = {65},
 websites = {http://dx.doi.org/10.1080/00958972.2012.679660},
 id = {7fc7aee0-e8ff-335e-9ed4-17395cf8bb3f},
 created = {2018-07-28T23:28:37.344Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:37.344Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Carvalho2012},
 source_type = {article},
 private_publication = {false},
 abstract = {A new palladium(II) complex with the amino acid L-tryptophan (Pd-TRP) was synthesized in aqueous solution and characterized by chemical and spectroscopic methods. Elemental, ESI-QTOF mass spectrometric, and thermal analyses of the solid compound permitted proposing the [Pd(C11H11N2O2)2]?·?2H2O composition. Infrared, Raman, and UV-Vis spectroscopic data indicate the coordination of the ligand to Pd(II) through monodentate oxygen of carboxylate and through nitrogen of the amino group. The 1H and 13C NMR spectroscopic data confirm coordination through the carboxylate, while 15N NMR data confirm coordination of nitrogen of NH2. Density functional theory studies con?rmed nitrogen and oxygen coordination to palladium(II) as a minimum of the potential energy surface with calculations of the hessians showing no imaginary frequencies. Biological studies were performed to provide information concerning the antibacterial activities of the compound. The Pd-TRP complex was shown to be active against Gram-positive and Gram-negative pathogenic bacterial strains.},
 bibtype = {article},
 author = {Carvalho, M A and Souza, B C and Paiva, R E F and Bergamini, F R G and Gomes, A F and Gozzo, F C and Lustri, W R and Formiga, A L B and Rigatto, G and Corbi, P P},
 doi = {10.1080/00958972.2012.679660},
 journal = {Journal of Coordination Chemistry},
 number = {10}
}

A new palladium(II) complex with the amino acid L-tryptophan (Pd-TRP) was synthesized in aqueous solution and characterized by chemical and spectroscopic methods. Elemental, ESI-QTOF mass spectrometric, and thermal analyses of the solid compound permitted proposing the [Pd(C11H11N2O2)2]?·?2H2O composition. Infrared, Raman, and UV-Vis spectroscopic data indicate the coordination of the ligand to Pd(II) through monodentate oxygen of carboxylate and through nitrogen of the amino group. The 1H and 13C NMR spectroscopic data confirm coordination through the carboxylate, while 15N NMR data confirm coordination of nitrogen of NH2. Density functional theory studies con?rmed nitrogen and oxygen coordination to palladium(II) as a minimum of the potential energy surface with calculations of the hessians showing no imaginary frequencies. Biological studies were performed to provide information concerning the antibacterial activities of the compound. The Pd-TRP complex was shown to be active against Gram-positive and Gram-negative pathogenic bacterial strains.

@article{
 title = {Crystal structure and theoretical studies of the keto-enol isomerism of N,N′-bis(salicylidene)-o-phenylenediamine (salophen)},
 type = {article},
 year = {2012},
 keywords = {DFT,Salicylaldehyde,Salophen,Tautomerism,o-Phenylenediamine},
 pages = {110-115},
 volume = {99},
 websites = {http://dx.doi.org/10.1016/j.saa.2012.09.002},
 publisher = {Elsevier B.V.},
 id = {af4799c8-50e6-312d-8f98-4a687929bf4d},
 created = {2018-07-28T23:28:37.386Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:37.386Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Mota2012},
 source_type = {article},
 private_publication = {false},
 abstract = {The Schiff base N,N′-bis(salicylidene)-o-phenylenediamine (salophen) was prepared by the condensation of salicylaldehyde with o-phenylenediamine in ethanol solution. The compound was characterized by elemental analysis, infrared (IR), 1H, 13C and 1H15N HMBC nuclear magnetic resonance (NMR) spectroscopic measurements, and also by X-ray diffraction. The tautomerism of salophen was also studied by calculations using density functional theory (DFT). Two of the three tautomers were shown to coexist. A comparison of the DFT data of the three tautomers has shown that the most stable one is salophen 1, which is in accordance with experimental X-ray crystallographic data. ©2012 Published by Elsevier B.V.},
 bibtype = {article},
 author = {Mota, Vinicius Z and De Carvalho, Gustavo S G and Corbi, Pedro P and Bergamini, Fernando R G and Formiga, André L B and Diniz, Renata and Freitas, Maria C R and Da Silva, Adilson D and Cuin, Alexandre},
 doi = {10.1016/j.saa.2012.09.002},
 journal = {Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy}
}

The Schiff base N,N′-bis(salicylidene)-o-phenylenediamine (salophen) was prepared by the condensation of salicylaldehyde with o-phenylenediamine in ethanol solution. The compound was characterized by elemental analysis, infrared (IR), 1H, 13C and 1H15N HMBC nuclear magnetic resonance (NMR) spectroscopic measurements, and also by X-ray diffraction. The tautomerism of salophen was also studied by calculations using density functional theory (DFT). Two of the three tautomers were shown to coexist. A comparison of the DFT data of the three tautomers has shown that the most stable one is salophen 1, which is in accordance with experimental X-ray crystallographic data. ©2012 Published by Elsevier B.V.

@article{
 title = {A binuclear silver complex with l-buthionine sulfoximine: synthesis, spectroscopic characterization, DFT studies and antibacterial assays},
 type = {article},
 year = {2012},
 keywords = {silver buthionine sulfoximine complex prepn DFT an},
 pages = {10372},
 volume = {2},
 websites = {http://xlink.rsc.org/?DOI=c2ra21433d},
 id = {b5fe39ec-a9a3-3560-9406-483349a4299d},
 created = {2018-07-28T23:28:38.041Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:38.041Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bergamini2012},
 source_type = {article},
 private_publication = {false},
 abstract = {A binuclear silver(I) complex with the amino acid L-buthionine sulfoximine (BSO) of compn. Ag2C8H16N2O3S was synthesized and characterized by chem. and spectroscopic measurements, and DFT (d. functional theory) studies. Solid-state 13C NMR (SSNMR) and IR vibrational spectroscopy (IR) analyses indicate the coordination of the nitrogen and carboxylate groups of the amino acid moiety to one of the silver atoms, while coordination to the second silver atom occurs through the nitrogen of the sulfoximine group. ESI-QTOF-MS measurements show the maintenance of the binuclear structure in soln. DFT studies confirm the proposed structure as a min. of the potential energy surface (PES) with calcns. of the hessians showing no imaginary frequencies. Raman spectroscopic measurements of the [Ag2(BSO)] complex led to the assignments of the Ag-N bonds. Biol. assays of BSO and [Ag2(BSO)] were performed by the well-diffusion method over Staphyloccocus aureus (Gram-pos.), Escherichia coli and Pseudomonas aeruginosa (Gram-neg.) bacterial strains. The ligand was inactive under the tested concn. (100 $μ$g mL-1). The [Ag2(BSO)] complex was active against the Gram-neg. and Gram-pos. bacteria tested, with MIC values of 3.125 $μ$g mL-1. [on SciFinder(R)]},
 bibtype = {article},
 author = {Bergamini, Fernando Rodrigues Goulart and Ferreira, Marcos Antonio and de Paiva, Raphael Enoque Ferraz and Gomes, Alexandre Ferreira and Gozzo, Fábio Cesar and Formiga, André Luiz Barboza and Corbi, Fabiana Cristina Andrade and Mazali, Italo Odone and Alves, Danilo Antonini and Lancellotti, Marcelo and Corbi, Pedro Paulo.},
 doi = {10.1039/c2ra21433d},
 journal = {RSC Advances},
 number = {27}
}

A binuclear silver(I) complex with the amino acid L-buthionine sulfoximine (BSO) of compn. Ag2C8H16N2O3S was synthesized and characterized by chem. and spectroscopic measurements, and DFT (d. functional theory) studies. Solid-state 13C NMR (SSNMR) and IR vibrational spectroscopy (IR) analyses indicate the coordination of the nitrogen and carboxylate groups of the amino acid moiety to one of the silver atoms, while coordination to the second silver atom occurs through the nitrogen of the sulfoximine group. ESI-QTOF-MS measurements show the maintenance of the binuclear structure in soln. DFT studies confirm the proposed structure as a min. of the potential energy surface (PES) with calcns. of the hessians showing no imaginary frequencies. Raman spectroscopic measurements of the [Ag2(BSO)] complex led to the assignments of the Ag-N bonds. Biol. assays of BSO and [Ag2(BSO)] were performed by the well-diffusion method over Staphyloccocus aureus (Gram-pos.), Escherichia coli and Pseudomonas aeruginosa (Gram-neg.) bacterial strains. The ligand was inactive under the tested concn. (100 $μ$g mL-1). The [Ag2(BSO)] complex was active against the Gram-neg. and Gram-pos. bacteria tested, with MIC values of 3.125 $μ$g mL-1. [on SciFinder(R)]

@article{
 title = {Synthesis, spectroscopic studies, and preliminary antibacterial assays of a palladium(II) complex with 2-mercaptothiazoline},
 type = {article},
 year = {2011},
 keywords = {2-Mercaptothiazoline,ESI-QTOF-mass spectrometry,Infrared spectroscopy,Palladium(II),Solid-state NMR spectroscopy},
 pages = {3092-3101},
 volume = {64},
 websites = {http://www.tandfonline.com/doi/abs/10.1080/00958972.2011.613463},
 id = {80857737-e975-30ab-a04c-0d8fe0f2ca00},
 created = {2018-07-28T23:28:36.993Z},
 file_attached = {false},
 profile_id = {6d4e9e22-09e3-3340-83ee-25b0de1090e1},
 group_id = {edb17a89-a16c-3c5d-8f2a-ce318aa08fb4},
 last_modified = {2018-07-28T23:28:36.993Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bergamini2011},
 source_type = {article},
 private_publication = {false},
 abstract = {In this article, synthesis of a palladium(II) complex with 2-mercaptothiazoline in aqueous solution is presented. Composition of the complex was defined as 1 : 2 (metal : ligand). Infrared and solid-state nuclear magnetic resonance indicate ligand coordination to Pd(II) through nitrogen of thiazole ring and sulfur of thiol. ESI-QTOF-mass spectrometric analysis shows primarily the dimeric form in solution. An antibiogram assay of the complex was performed by the disc diffusion method. The compound did not show antibacterial activity against the considered bacterial cells in the tested concentrations.},
 bibtype = {article},
 author = {Bergamini, F R G and Abbehausen, C and Magalhães, A and Lustri, W R and Gomes, A F and Gozzo, F C and Corbi, P P},
 doi = {10.1080/00958972.2011.613463},
 journal = {Journal of Coordination Chemistry},
 number = {17}
}

In this article, synthesis of a palladium(II) complex with 2-mercaptothiazoline in aqueous solution is presented. Composition of the complex was defined as 1 : 2 (metal : ligand). Infrared and solid-state nuclear magnetic resonance indicate ligand coordination to Pd(II) through nitrogen of thiazole ring and sulfur of thiol. ESI-QTOF-mass spectrometric analysis shows primarily the dimeric form in solution. An antibiogram assay of the complex was performed by the disc diffusion method. The compound did not show antibacterial activity against the considered bacterial cells in the tested concentrations.