@article{pilkington_development_2023,
	title = {Development of an {Enhanced} {Recovery} {After} {Surgery} {Surgical} {Safety} {Checklist} {Through} a {Modified} {Delphi} {Process}},
	volume = {6},
	issn = {2574-3805},
	doi = {10.1001/jamanetworkopen.2022.48460},
	abstract = {IMPORTANCE: Enhanced Recovery After Surgery (ERAS) guidelines and the World Health Organization Surgical Safety Checklist (SSC) are 2 well-established tools for optimizing patient outcomes perioperatively. OBJECTIVE: To integrate the 2 tools to facilitate key perioperative decision-making. EVIDENCE REVIEW: Snowball sampling recruited international ERAS users from multiple clinical specialties. A 3-round modified Delphi consensus model was used to evaluate 27 colorectal or gynecologic oncology ERAS recommendations for appropriateness to include in an ERAS SSC. Items attaining potential consensus (65\%-69\% agreement) or consensus (≥70\% agreement) were used to develop ERAS-specific SSC prompts. These proposed prompts were evaluated in a second round by the panelists with regard to inclusion, modification, or exclusion. A final round of interactive discussion using quantitative consensus and qualitative comments was used to produce an ERAS-specific SSC. The panel of ERAS experts included surgeons, anesthesiologists, and nurses within diverse practice settings from 19 countries. Final analysis was conducted in May 2022. FINDINGS: Round 1 was completed by 105 experts from 18 countries. Eleven ERAS components met criteria for development into an SSC prompt. Round 2 was completed by 88 experts. There was universal consensus (≥70\% agreement) to include all 37 proposed prompts within the 3-part ERAS-specific SSC (used prior to induction of anesthesia, skin incision, and leaving the operating theater). A third round of qualitative comment review and expert discussion was used to produce a final ERAS-specific SSC that expands on the current WHO SSC to include discussion of analgesia strategies, nausea prevention, appropriate fasting, fluid management, anesthetic protocols, appropriate skin preparation, deep vein thrombosis prophylaxis, hypothermia prevention, use of foley catheters, and surgical access. The final products of this work included an ERAS-specific SSC ready for implementation and a set of recommendations to integrate ERAS elements into existing SSCs. CONCLUSIONS AND RELEVANCE: The SSC could be modified to align with ERAS recommendations for patients undergoing major surgery within an ERAS protocol. The stakeholder- and expert-generated ERAS SSC could be adopted directly, or the recommendations for modification could be applied to an existing institutional SSC to facilitate implementation.},
	language = {eng},
	number = {2},
	journal = {JAMA Netw Open},
	author = {Pilkington, M. and Nelson, G. and Cauley, C. and Holder, K. and Ljungqvist, O. and Molina, G. and Oodit, R. and Brindle, M. E.},
	month = feb,
	year = {2023},
	keywords = {*Enhanced Recovery After Surgery, Checklist, Consensus, Female, Humans, Operating Rooms, Perioperative Care/methods},
	pages = {e2248460},
}

@article{oldfield_experiences_2022,
	title = {Experiences, patient interactions and knowledge regarding the use of cannabis as a medicine in a cohort of {New} {Zealand} doctors in an oncology setting},
	volume = {98},
	issn = {1469-0756},
	doi = {10.1136/postgradmedj-2020-139013},
	abstract = {PURPOSE OF STUDY: To explore the experiences, patient interactions and knowledge regarding the use of cannabis as a medicine in New Zealand doctors in an oncology setting.
STUDY DESIGN: An observational cross-sectional survey undertaken between November 2019 and January 2020 across four secondary-care hospital oncology departments within New Zealand (Auckland, Wellington, Christchurch and Dunedin). Participants were a convenience sample of doctors; consultants, registrars, medical officers of special status and house surgeons working in oncology departments. Of 53 individuals approached, 45 participated (85\% Response Rate). The primary outcome was reporteddoctor-patient interactions. Secondary outcomes included knowledge of cannabis-based products, their efficacy, prescribing regulations and educational access.
RESULTS: Of 44 doctors, 37 (84\%, 95\% CI: 70 to 93) reported patient requests to prescribe cannabis-based products and 43 (98\%, 95\% CI: 88 to 100) reported patients using illicit cannabis for medical symptoms. Primary request reasons were pain, nausea/vomiting and cancer treatment. 33/45 (73\%, 95\% CI: 58 to 85) cited knowledge of at least one cannabis-based product and 27/45 (60\%, 95\% CI: 44 to 74) indicated at least one condition that had evidence of efficacy. 36/44 (82\%, 95\% CI: 67 to 92) expressed future prescribing concerns but all were willing to use a cannabis-based product developed with traditional medical provenance.
CONCLUSION: In the oncology setting, patients are asking doctors about symptomatic and curative treatment with cannabis-based products. Doctors are not biased against the use of products showing medical provenance; however, NZ-specific clinical and regulatory guidelines are essential to support patient discussions and appropriate prescribing.},
	language = {eng},
	number = {1155},
	journal = {Postgraduate Medical Journal},
	author = {Oldfield, Karen and Eathorne, Allie and Tewhaiti-Smith, Jordan and Beasley, Richard and Semprini, Alex and Braithwaite, Irene},
	month = jan,
	year = {2022},
	pmid = {33218966},
	keywords = {Adult, Aged, Attitude of Health Personnel, Cannabis, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Medical Marijuana, Medicine, Middle Aged, Neoplasms, New Zealand, Oncology, Physician-Patient Relations, Physicians, chemotherapy, complementary medicine, education \& training (see medical education \& training), pain management},
	pages = {35--42},
}

@article{li_risk_2021,
	title = {Risk factors for poor outcomes in hospitalised {COVID}-19 patients: {A} systematic review and meta-analysis},
	volume = {11},
	issn = {2047-2986},
	shorttitle = {Risk factors for poor outcomes in hospitalised {COVID}-19 patients},
	doi = {10.7189/jogh.11.10001},
	abstract = {Background: Understanding the risk factors for poor outcomes among COVID-19 patients could help identify vulnerable populations who would need prioritisation in prevention and treatment for COVID-19. We aimed to critically appraise and synthesise published evidence on the risk factors for poor outcomes in hospitalised COVID-19 patients.
Methods: We searched PubMed, medRxiv and the WHO COVID-19 literature database for studies that reported characteristics of COVID-19 patients who required hospitalisation. We included studies published between January and May 2020 that reported adjusted effect size of any demographic and/or clinical factors for any of the three poor outcomes: mortality, intensive care unit (ICU) admission, and invasive mechanical ventilation. We appraised the quality of the included studies using Joanna Briggs Institute appraisal tools and quantitatively synthesised the evidence through a series of random-effect meta-analyses. To aid data interpretation, we further developed an interpretation framework that indicated strength of the evidence, informed by both quantity and quality of the evidence.
Results: We included a total of 40 studies in our review. Most of the included studies (29/40, 73\%) were assessed as "good quality", with assessment scores of 80 or more. We found that male sex (pooled odds ratio (OR) = 1.32 (95\% confidence interval (CI) = 1.18-1.48; 20 studies), older age (OR = 1.05, 95\% CI = 1.04-1.07, per one year of age increase; 10 studies), obesity (OR = 1.59, 95\% CI = 1.02-2.48; 4 studies), diabetes (OR = 1.25, 95\% CI = 1.11-1.40; 11 studies) and chronic kidney diseases (6 studies; OR = 1.57, 95\% CI = 1.27-1.93) were associated with increased risks for mortality with the greatest strength of evidence based on our interpretation framework. We did not find increased risk of mortality for several factors including chronic obstructive pulmonary diseases (5 studies), cancer (4 studies), or current smoker (5 studies); however, this does not indicate absence of risk due to limited data on each of these factors.
Conclusion: Male sex, older age, obesity, diabetes and chronic kidney diseases are important risk factors of COVID-19 poor outcomes. Our review provides not only an appraisal and synthesis of evidence on the risk factors of COVID-19 poor outcomes, but also a data interpretation framework that could be adopted by relevant future research.},
	language = {eng},
	journal = {Journal of Global Health},
	author = {Li, You and Ashcroft, Thulani and Chung, Alexandria and Dighero, Izzie and Dozier, Marshall and Horne, Margaret and McSwiggan, Emilie and Shamsuddin, Azwa and Nair, Harish},
	month = mar,
	year = {2021},
	pmid = {33767855},
	pmcid = {PMC7980087},
	keywords = {Aged, COVID-19, Comorbidity, Female, Hospitalization, Humans, Intensive Care Units, Male, Respiration, Artificial, Risk Factors, SARS-CoV-2, Severity of Illness Index},
	pages = {10001},
}

@article{hildebrandt_randomized_2020,
	title = {Randomized {Controlled} {Trial} {Comparing} {Health} {Coach}-{Delivered} {Smartphone}-{Guided} {Self}-{Help} {With} {Standard} {Care} for {Adults} {With} {Binge} {Eating}.},
	volume = {177},
	issn = {1535-7228 0002-953X},
	doi = {10/ghsrqp},
	abstract = {OBJECTIVE: Cognitive-behavioral therapy (CBT) has shown efficacy in the treatment of eating disorders. The authors conducted a randomized controlled telemedicine trial  of CBT-guided self-help (CBT-GSH) assisted with a smartphone app, Noom Monitor, for  binge eating with or without purging. They hypothesized that coach-delivered CBT-GSH  telemedicine sessions plus Noom Monitor would yield greater reductions in symptoms  of binge eating, purging, and eating disorders compared with standard care. METHODS:  Fifty-two-week outcomes for CBT-GSH plus Noom Monitor (N=114) were compared with  outcomes for standard care (N=111) among members of an integrated health care system  in the Pacific Northwest. Patients in the health system who met inclusion criteria  were ≥18 years old, had a body mass index ≥18.5, met criteria for DSM-5 binge eating  disorder or bulimia nervosa, had 12 months of continuous health care enrollment in  Kaiser Permanente Northwest, and had a personal smartphone. Participants received  eight CBT-GSH telemedicine sessions over 12 weeks administered by health coaches,  and outcomes were assessed at baseline and at weeks 4, 8, 12, 26, and 52. The use of  available treatment offered within the Kaiser Permanente health care system was  permitted for participants assigned to standard care. RESULTS: Participants who  received CBT-GSH plus Noom Monitor reported significant reductions in objective  binge-eating days (β=-0.66, 95\% CI=-1.06, -0.25; Cohen's d=-1.46, 95\% CI=-4.63,  -1.09) and achieved higher rates of remission (56.7\% compared with 30\%; number  needed to treat=3.74) at 52 weeks compared with participants in standard care, none  of whom received any eating disorder treatment during the intervention period  (baseline and weeks 1-12). Similar patterns emerged for compensatory behaviors  (vomiting, use of laxatives, and excessive exercise; 76.3\% compared with 56.8\%;  number needed to treat=5.11), eating disorder symptoms (body shape, weight, eating  concerns, and dietary restraint), and clinical impairment (Cohen's d=-10.07, -2.15).  CONCLUSIONS: These results suggest that CBT-GSH plus Noom Monitor delivered via  telemedicine by routine-practice health coaches in a nonacademic health care system  yields reductions in symptoms and impairment over 52 weeks compared with standard  care.},
	language = {eng},
	number = {2},
	journal = {The American journal of psychiatry},
	author = {Hildebrandt, Tom and Michaeledes, Andreas and Mayhew, Meghan and Greif, Rebecca and Sysko, Robyn and Toro-Ramos, Tatiana and DeBar, Lynn},
	month = feb,
	year = {2020},
	pmid = {32008396},
	note = {Place: United States},
	keywords = {*Cognitive, *Cognitive Behavioral Therapy, *Computers, *Eating Disorders, *Gender Differences, *Metabolism, *Obsessive-Compulsive Disorder, *Smartphone, Adolescent, Adult, Binge-Eating Disorder/*therapy, Female, Humans, Male, Mentoring, Middle Aged, Telemedicine/*methods, Young Adult},
	pages = {134--142},
}

@article{burt_marijuana_2020,
	title = {Marijuana use and coronary artery disease in young adults},
	volume = {15},
	issn = {1932-6203 (Electronic) 1932-6203 (Linking)},
	doi = {10.1371/journal.pone.0228326},
	abstract = {BACKGROUND: Marijuana is the most popular drug of abuse in the United States. The association between its use and coronary artery disease has not yet been fully elucidated. This study aims to determine the frequency of coronary artery disease among young to middle aged adults presenting with chest pain who currently use marijuana as compared to nonusers. METHODS: In this retrospective study, 1,420 patients with chest pain or angina equivalent were studied. Only men between 18 and 40 years and women between 18 and 50 years of age without history of cardiac disease were included. All patients were queried about current or prior cannabis use and underwent coronary CT angiography. Each coronary artery on coronary CT angiography was assessed based on the CAD-RADS reporting system. RESULTS: A total of 146 (10.3\%) out of 1,420 patients with chest pain were identified as marijuana users. Only 6.8\% of the 146 marijuana users had evidence of coronary artery disease on coronary CT angiography. In comparison, the rate was 15.0\% among the 1,274 marijuana nonusers (p = 0.008). After accounting for other cardiac risk factors in a multivariate analysis, the negative association between marijuana use and coronary artery disease on coronary CT angiography diminished (p = 0.12, 95\% CI 0.299-1.15). A majority of marijuana users were younger than nonusers and had a lower frequency of hypertension and diabetes than nonusers. There was no statistical difference in lipid panel values between the two groups. Only 2 out of 10 marijuana users with coronary artery disease on coronary CT angiography had hemodynamically significant stenosis. CONCLUSION: Among younger patients being evaluated for chest pain, self-reported cannabis use conferred no additional risk of coronary artery disease as detected on coronary CT angiography.},
	number = {1},
	journal = {PLoS One},
	author = {Burt, J. R. and Agha, A. M. and Yacoub, B. and Zahergivar, A. and Pepe, J.},
	year = {2020},
	pmcid = {PMC6988970},
	keywords = {Adult, Case-Control Studies, Computed Tomography Angiography, Coronary Artery Disease/diagnostic imaging/*epidemiology, Female, Humans, Male, Marijuana Use/adverse effects/*epidemiology, Middle Aged, Retrospective Studies, United States/epidemiology, Young Adult},
	pages = {e0228326},
}

Website  abstract   bibtex   

@article{
 title = {Intrinsic functional and structural connectivity of emotion regulation networks in obsessive-compulsive disorder},
 type = {article},
 year = {2019},
 identifiers = {[object Object]},
 keywords = {Adult,Amygdala,Case-Control Studies,Emotions,Female,Humans,Magnetic Resonance Imaging,Male,Obsessive-Compulsive Disorder},
 pages = {110-120},
 volume = {36},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/30253000},
 id = {da7dfdeb-3ba9-322b-bbdc-f9d9b860019d},
 created = {2020-09-17T09:27:48.121Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:48.121Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {Despite emotion regulation being altered in patients with obsessive-compulsive disorder (OCD), no studies have investigated its relation to multimodal amygdala connectivity. We compared corticolimbic functional and structural connectivity between OCD patients and healthy controls (HCs), and correlated this with the dispositional use of emotion regulation strategies and with OCD severity. OCD patients (n = 73) and HCs (n = 42) were assessed for suppression and reappraisal strategies using the Emotion Regulation Questionnaire (ERQ) and for OCD severity using the Yale-Brown Obsessive-Compulsive Scale. Resting-state functional magnetic resonance imaging (rs-fMRI) connectivity maps were generated using subject-specific left amygdala (LA) and right amygdala (RA) masks. We identified between-group differences in amygdala whole-brain connectivity, and evaluated the moderating effect of ERQ strategies. Significant regions and amygdala seeds were used as targets in probabilistic tractography analysis. Patients scored higher in suppression and lower in reappraisal. We observed higher rs-fMRI RA-right postcentral gyrus (PCG) connectivity in HC, and in patients this was correlated with symptom severity. Reappraisal scores were associated with higher negative LA-left insula connectivity in HC, and suppression scores were negatively associated with LA-precuneus and angular gyri connectivity in OCD. Structurally, patients showed higher mean diffusivity in tracts connecting the amygdala with the other targets. RA-PCG connectivity is diminished in patients, while disrupted emotion regulation is related to altered amygdala connectivity with the insula and posterior brain regions. Our results are the first showing, from a multimodal perspective, the association between amygdala connectivity and specific emotional processing domains, emphasizing the importance of amygdala connectivity in OCD pathophysiology.},
 bibtype = {article},
 author = {Picó-Pérez, Maria and Ipser, Jonathan and Taylor, Paul and Alonso, Pino and López-Solà, Clara and Real, Eva and Segalàs, Cinto and Roos, Annerine and Menchón, José M and Stein, Dan J and Soriano-Mas, Carles},
 journal = {Depression and Anxiety},
 number = {2}
}

Paper  doi  abstract   bibtex   

@article{costa_impact_2019,
	title = {The impact of intimate partner violence on forgone healthcare: a population-based, multicentre {European} study},
	volume = {29},
	issn = {1464-360X},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30169658},
	doi = {10.1093/eurpub/cky167},
	abstract = {BACKGROUND: To examine the relationship between forgone healthcare and involvement in intimate partner violence (IPV) as victims, perpetrators or both. METHODS: This cross-sectional multicentre study assessed community non-institutionalized residents (n = 3496, aged 18-64) randomly selected from six European cities: Athens, Budapest, London, Östersund, Porto, Stuttgart. A common questionnaire was used, including self-reports of IPV and forgone healthcare ('Have you been in need of a certain care service in the past year, but did not seek any help?'). Odds ratios (ORs), 95\% confidence intervals (CIs) were computed fitting logistic regression models adjusted for city, chronic disease, self-assessed health status and financial strain. RESULTS: Participants experiencing past year IPV (vs. no violence) reported more often to forgone healthcare (n = 3279, 18.6\% vs. 15.3\%, P = 0.016). IPV experienced as both a victim and perpetrator was associated with forgone healthcare (adjusted OR, 95\%CI: 1.32, 1.02-1.70). CONCLUSION: IPV was associated with forgone healthcare, particularly for those experiencing violence as both victims and perpetrators. Results suggest that preventing IPV among adults may improve timely healthcare uptake.},
	language = {eng},
	number = {2},
	journal = {European journal of public health},
	author = {Costa, Diogo and Hatzidimitriadou, Eleni and Ioannidi-Kapolo, Elli and Lindert, Jutta and Soares, Joaquim and Sundin, Örjan and Toth, Olga and Barros, Henrique},
	month = apr,
	year = {2019},
	keywords = {Adolescent, Adult, Cross-Sectional Studies, Europe, Female, Health Status, Humans, Intimate Partner Violence/*statistics \& numerical data, Male, Middle Aged, Patient Acceptance of Health Care/*statistics \& numerical data, Socioeconomic Factors, Spouse Abuse/statistics \& numerical data, Young Adult},
	pages = {359--364},
}

@article {650292,
	title = {Ovarian Cancer: Prevalence in Incidental Simple Adnexal Cysts Initially Identified in CT Examinations of the Abdomen and Pelvis},
	journal = {Radiology},
	volume = {286},
	number = {1},
	year = {2018},
	month = {2018 01},
	pages = {196-204},
	abstract = {Purpose To evaluate the rate of malignancy in incidentally detected simple adnexal cysts at computed tomography (CT) to determine if simple-appearing cysts require follow-up. Materials and Methods In this HIPAA-compliant, institutional review board-approved retrospective cohort study, an institutional database was searched for abdominal and pelvic CT studies performed between June 2003 and December 2010 in women reported to have adnexal cysts. Adnexal cyst characterization was determined by prospective report description as well as image review by a research fellow and by a fellowship-trained abdominal radiologist for examinations with disagreement between the original report and the research fellow{\textquoteright}s assessment. Patients with known ovarian cysts or ovarian cancer at time of the index CT examination were excluded. Clinical outcome was assessed by using follow-up imaging studies, medical records, and the state cancer registry. Benign outcome was determined by benign findings at surgery, a decrease in size or resolution of a simple-appearing cyst at follow-up imaging, or stability of the cyst for at least 1 year. Descriptive statistics and 95\% confidence intervals (CIs) were calculated. Results Among 42 111 women who underwent abdominal and pelvic CT examinations in the study period, 2763 (6.6\%; 95\% CI: 6.3\%, 6.8\%) (mean age, 48.1 years {\textpm} 18.1; range, 15-102 years) had a newly detected finding of ovarian cyst described in the body or impression section of the report. Median cyst size was 3.1 cm (range, 0.8-20.0 cm). Eighteen (0.7\%; 95\% CI: 0.4\%, 1.0\%) of 2763 patients were found to have ovarian cancer after an average follow-up of 5.1 years {\textpm} 3.8 (range, 0-12.8 years). None (95\% CI: 0\%, 0.4\%) of 1031 women with simple-appearing cysts were given a diagnosis of ovarian cancer. This included none (95\% CI: 0\%, 0.4\%) of 904 women with simple-appearing cysts with an adequate reference standard for benign outcome. Conclusion The prevalence of previously unknown adnexal cysts at CT was 6.6\%, with an ovarian cancer rate of 0.7\% (95\% CI: 0.4\%, 1.0\%). All simple-appearing cysts were benign (95\% CI: 99.6\%, 100\%).  RSNA, 2017 Online supplemental material is available for this article.},
	keywords = {Abdomen, Adult, Aged, Female, Humans, Incidental Findings, Middle Aged, Ovarian Cysts, Ovarian Neoplasms, Pelvis, Retrospective Studies, Tomography, X-Ray Computed},
	issn = {1527-1315},
	doi = {10.1148/radiol.2017162139},
	author = {Johannes Boos and Olga R Brook and Jieming Fang and Alexander Brook and Levine, Deborah}
}

Paper  abstract   bibtex   

@misc{baker_s.c._systematic_2017,
	title = {Systematic {Review} of {Interventions} to {Reduce} {Psychiatric} {Morbidity} in {Parents} and {Children} {After} {PICU} {Admissions}},
	url = {http://journals.lww.com/pccmjournal},
	abstract = {OBJECTIVE:: To describe and evaluate interventions aimed at reducing psychiatric morbidity in parents and children discharged from PICU. DATA SOURCES:: A systematic review of the literature was undertaken, searching EMBASE, PSYCHinfo, MEDLINE, and CINAHL. Experts in the field were contacted to identify unpublished studies. STUDY SELECTION:: Exclusion criteria: Studies with participants above age 18 or drawn from a neonatal ICU, studies not in English, and those not measuring psychopathology. DATA EXTRACTION:: Seven hundred fifty-three articles initially identified were hand searched which identified three studies, with a further three studies found by contacting experts in the field. Of these, three were randomized controlled trials and three feasibility studies. DATA SYNTHESIS:: The interventions primarily targeted parents (particularly mothers), with the aim of reducing psychopathology especially posttraumatic stress disorder. Findings from these few studies demonstrated that interventions can lead to a reduction in parent and child psychopathology. Key ingredients of these interventions included psychoeducation, parent support after discharge, offering intervention to those families at high risk of developing psychopathology as identified by screening at the point of discharge, follow-up of all families with the aim of case finding, and specific interventions to target posttraumatic stress disorder symptoms. CONCLUSIONS:: Intervention studies are few but do lead to reductions in parent and child psychopathology. There is sufficient information to suggest some of these interventions could be supported and further evaluated. Copyright ©2017The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies},
	journal = {Pediatric Critical Care Medicine},
	author = {{Baker S.C.} and {Gledhill J.A.}},
	year = {2017},
	keywords = {*morbidity, *psychiatric intensive care unit, Child, Cinahl, Embase, Medline, Neonatal intensive care unit, PsycINFO, adult, case finding, controlled study, family study, feasibility study, female, follow up, human, intervention study, mental disease, mother, newborn, posttraumatic stress disorder, psychoeducation, screening, systematic review, young adult}
}

Paper  abstract   bibtex   

@misc{ferre_c.l._caregiver-directed_2016,
	title = {Caregiver-directed home-based intensive bimanual training in young children with unilateral spastic cerebral palsy: {A} randomized trial},
	url = {http://www.wiley.com/bw/journal.asp?ref=0012-1622&site=1},
	abstract = {Aim: To examine the efficacy of caregiver-directed, home-based intensive bimanual training in children with unilateral spastic cerebral palsy (USCP) using a randomized control trial. Method: Twenty-four children (ages 2y 6mo-10y 1mo; 10 males, 14 females) performed home-based activities directed by a caregiver for 2 hours per day, 5 days per week, for 9 weeks (total=90h). Cohorts of children were age-matched into groups and randomized to receive home-based hand-arm bimanual intensive therapy (H-HABIT; n=12) or lower-limb functional intensive training (LIFT-control; n=12). Caregivers were trained before the intervention and supervised remotely via telerehabilitation. Dexterity and bimanual hand function were assessed using the Box and Blocks test (BBT) and the Assisting Hand Assessment (AHA) respectively. Caregiver perception of functional goals was measured using the Canadian Occupational Performance Measure (COPM). Results: H-HABIT showed greater improvement on the BBT compared to LIFT-control and no improvement on the AHA. H-HABIT demonstrated significant improvement in COPM-Performance compared to LIFT-control and both groups showed equal improvement in COPM-Satisfaction. Interpretation: H-HABIT improved dexterity and performance of functional goals, but not bimanual performance, in children with USCP compared to a control group receiving intervention of equal intensity/duration that also controlled for increased caregiver attention. Home-based models provide a valuable, family-centered approach to achieve increased treatment intensity. Copyright © 2016 Mac Keith Press.},
	journal = {Developmental Medicine and Child Neurology},
	author = {{Ferre C.L.} and {Brandao M.} and {Surana B.} and {Dew A.P.} and {Moreau N.G.} and {Gordon A.M.}},
	year = {2016},
	keywords = {*caregiver, *cerebral palsy, Child, attention, clinical article, clinical trial, control group, controlled clinical trial, controlled study, endogenous compound, female, hand function, human, intensive care, lower limb, male, model, perception, preschool child, randomized controlled trial, satisfaction, telerehabilitation}
}

@article{coullin_involvement_2015,
	title = {The involvement of the trans-generational effect in the high incidence of the hydatidiform mole in {Africa}},
	volume = {36},
	issn = {1532-3102},
	doi = {10.1016/j.placenta.2014.10.017},
	abstract = {INTRODUCTION: While the incidence of various chromosomal anomalies observed, including triploid partial moles is independent of the socio-economic level, higher incidences of complete hydatidiform mole "CHM" is generally associated with under developed areas. Moreover, studies have shown that some nutritional deficiencies are related to the abnormal development of oocytes and placenta. In Senegal and Morocco, the annual seasonal cycle contains one period with food shortages and the incidence of complete moles is significant. Accordingly, accurate statistical analyses have been performed in these two countries.
METHODS: Each month during a one year period, we investigated the occurrence of normal conceptions, molar conceptions and the conception of the future patients in Senegal and Morocco. The comparisons of the conception dates for these three types of conception were analyzed using the Chi-squared test.
RESULTS: 94\% of the patients were conceived just prior to the period in the year with food shortages. Consequently, the development of the female embryos occurred under nutritional constraints, which negatively affect the recruitment of the vital factors required for the normal synthesis of DNA, proteins and placental differentiation.
DISCUSSIONS: A nutritional deficiency in the mother at conception of their daughter (future patient) is implicated in the higher incidence of CHM in their daughters' filiation. These nutritional deficiencies during the first weeks of pregnancy will have repercussions on the normal development of the oocytes. Accordingly, these developmental impairments take place during the embryonic life of the future mothers of complete moles and not during the conception of the moles themselves.},
	language = {eng},
	number = {1},
	journal = {Placenta},
	author = {Coullin, P. and Diatta, A. L. and Boufettal, H. and Feingold, J. and Leguern, E. and Candelier, J. J.},
	month = jan,
	year = {2015},
	pmid = {25468544},
	keywords = {Female, Humans, Hydatidiform Mole, Incidence, Maternal Nutritional Physiological Phenomena, Morocco, Nutrition, Nutritional Status, Oocyte, Placental development, Pregnancy, Senegal, Uterine Neoplasms, trophoblast},
	pages = {48--51},
}

@article{silverberg_cumulative_2015,
	title = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}: {A} {Cohort} {Study}},
	volume = {163},
	issn = {1539-3704},
	shorttitle = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}},
	doi = {10.7326/M14-2768},
	abstract = {BACKGROUND: Cancer is increasingly common among persons with HIV.
OBJECTIVE: To examine calendar trends in cumulative cancer incidence and hazard rate by HIV status.
DESIGN: Cohort study.
SETTING: North American AIDS Cohort Collaboration on Research and Design during 1996 to 2009.
PARTICIPANTS: 86 620 persons with HIV and 196 987 uninfected adults.
MEASUREMENTS: Cancer type-specific cumulative incidence by age 75 years and calendar trends in cumulative incidence and hazard rates, each by HIV status.
RESULTS: Cumulative incidences of cancer by age 75 years for persons with and without HIV, respectively, were as follows: Kaposi sarcoma, 4.4\% and 0.01\%; non-Hodgkin lymphoma, 4.5\% and 0.7\%; lung cancer, 3.4\% and 2.8\%; anal cancer, 1.5\% and 0.05\%; colorectal cancer, 1.0\% and 1.5\%; liver cancer, 1.1\% and 0.4\%; Hodgkin lymphoma, 0.9\% and 0.09\%; melanoma, 0.5\% and 0.6\%; and oral cavity/pharyngeal cancer, 0.8\% and 0.8\%. Among persons with HIV, calendar trends in cumulative incidence and hazard rate decreased for Kaposi sarcoma and non-Hodgkin lymphoma. For anal, colorectal, and liver cancer, increasing cumulative incidence, but not hazard rate trends, were due to the decreasing mortality rate trend (-9\% per year), allowing greater opportunity to be diagnosed. Despite decreasing hazard rate trends for lung cancer, Hodgkin lymphoma, and melanoma, cumulative incidence trends were not seen because of the compensating effect of the declining mortality rate.
LIMITATION: Secular trends in screening, smoking, and viral co-infections were not evaluated.
CONCLUSION: Cumulative cancer incidence by age 75 years, approximating lifetime risk in persons with HIV, may have clinical utility in this population. The high cumulative incidences by age 75 years for Kaposi sarcoma, non-Hodgkin lymphoma, and lung cancer support early and sustained antiretroviral therapy and smoking cessation.},
	language = {eng},
	number = {7},
	journal = {Annals of Internal Medicine},
	author = {Silverberg, Michael J. and Lau, Bryan and Achenbach, Chad J. and Jing, Yuezhou and Althoff, Keri N. and D'Souza, Gypsyamber and Engels, Eric A. and Hessol, Nancy A. and Brooks, John T. and Burchell, Ann N. and Gill, M. John and Goedert, James J. and Hogg, Robert and Horberg, Michael A. and Kirk, Gregory D. and Kitahata, Mari M. and Korthuis, Philip T. and Mathews, William C. and Mayor, Angel and Modur, Sharada P. and Napravnik, Sonia and Novak, Richard M. and Patel, Pragna and Rachlis, Anita R. and Sterling, Timothy R. and Willig, James H. and Justice, Amy C. and Moore, Richard D. and Dubrow, Robert and {North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS}},
	month = oct,
	year = {2015},
	pmid = {26436616},
	pmcid = {PMC4711936},
	keywords = {Adult, Age Distribution, Aged, Anus Neoplasms, Cohort Studies, Colorectal Neoplasms, Comorbidity, Female, HIV Infections, Humans, Incidence, Liver Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Male, Middle Aged, Neoplasms, North America, Proportional Hazards Models, Sarcoma, Kaposi},
	pages = {507--518},
}

Paper  doi  abstract   bibtex   

@article{Heiker-2014-ID6,
  title     = {Identification of genetic loci associated with different responses to
               high-fat diet-induced obesity in C57{BL}/6N and C57{BL}/6J substrains.},
  abstract  = {We have recently demonstrated that C57{BL}/6{NT}ac and C57{BL}/6{JR}j
               substrains are significantly different in their response to high-fat
               diet-induced obesity ({DIO}). The C57{BL}/6{JR}j substrain seems to be
               protected from {DIO} and genetic differences between C57{BL}/6J and
               C57{BL}/6N substrains at 11 single nucleotide polymorphism ({SNP}) loci
               have been identified. To define genetic variants as well as differences in
               parameters of glucose homeostasis and insulin sensitivity between
               C57{BL}/6{NT}ac and C57{BL}/6{JR}j substrains that may explain the
               different response to {DIO}, we analyzed 208 first backcross ({BC}1)
               hybrids of C57{BL}/6{NT}ac and C57{BL}/6{JR}j [(C57{BL}/6{NT}ac ×
               C57{BL}/6{JR}j)F1 × C57{BL}/6{NT}ac] mice. Body weight, epigonadal and
               subcutaneous fat mass, circulating leptin, as well as parameters of glucose
               metabolism were measured after 10 wk of high-fat diet ({HFD}). Genetic
               profiling of {BC}1 hybrids were performed using TaqMan {SNP} genotyping
               assays. Furthermore, to assess whether {SNP} polymorphisms could affect
               m{RNA} level, we carried out gene expression analysis in murine liver
               samples. Human subcutaneous adipose tissue was used to verify murine data
               of {SNAP}29. We identified four sex-specific variants that are associated
               with the extent of {HFD}-induced weight gain and fat depot mass. {BC}1
               hybrids carrying the combination of risk or beneficial alleles exhibit the
               phenotypical extremes of the parental strains. Murine and human {SC}
               expression analysis revealed Snap29 as strongest candidate. Our data
               indicate an important role of these loci in responsiveness to {HFD}-induced
               obesity and suggest genes of the synaptic vesicle release system such as
               Snap29 being involved in the regulation of high-fat {DIO}.},
  author    = {Heiker, John T and Kunath, Anne and Kosacka, Joanna and Flehmig, Gesine and
               Knigge, Anja and Kern, Matthias and Stumvoll, Michael and Kovacs, Peter and
               Blüher, Matthias and Klöting, Nora},
  volume    = {46},
  number    = {11},
  pages     = {377--84},
  year      = {2014},
  month     = {6},
  url       = {http://www.pubmed.org/24692188},
  pmid      = {24692188},
  doi       = {10.1152/physiolgenomics.00014.2014},
  keywords  = {Animals, Humans, Mice, Male, Adipose Tissue, Alleles, Body Weight, Diet,
               High-Fat, Female, Genetic Loci, Genotype, Glucose, Leptin, Mice, Inbred
               C57{BL}, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Vesicular
               Transport Proteins, Weight Gain},
  file      = {FULLTEXT:pdfs/000/000/000000006.pdf:PDF}
}

@article{hippisley-cox_performance_2014,
	title = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice: a validation study},
	volume = {4},
	issn = {2044-6055},
	shorttitle = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice},
	doi = {10.1136/bmjopen-2014-005809},
	abstract = {OBJECTIVES: To validate the performance of a set of risk prediction algorithms developed using the QResearch database, in an independent sample from general practices contributing to the Clinical Research Data Link (CPRD).
SETTING: Prospective open cohort study using practices contributing to the CPRD database and practices contributing to the QResearch database.
PARTICIPANTS: The CPRD validation cohort consisted of 3.3 million patients, aged 25-99 years registered at 357 general practices between 1 Jan 1998 and 31 July 2012. The validation statistics for QResearch were obtained from the original published papers which used a one-third sample of practices separate to those used to derive the score. A cohort from QResearch was used to compare incidence rates and baseline characteristics and consisted of 6.8 million patients from 753 practices registered between 1 Jan 1998 and until 31 July 2013.
OUTCOME MEASURES: Incident events relating to seven different risk prediction scores: QRISK2 (cardiovascular disease); QStroke (ischaemic stroke); QDiabetes (type 2 diabetes); QFracture (osteoporotic fracture and hip fracture); QKidney (moderate and severe kidney failure); QThrombosis (venous thromboembolism); QBleed (intracranial bleed and upper gastrointestinal haemorrhage). Measures of discrimination and calibration were calculated.
RESULTS: Overall, the baseline characteristics of the CPRD and QResearch cohorts were similar though QResearch had higher recording levels for ethnicity and family history. The validation statistics for each of the risk prediction scores were very similar in the CPRD cohort compared with the published results from QResearch validation cohorts. For example, in women, the QDiabetes algorithm explained 50\% of the variation within CPRD compared with 51\% on QResearch and the receiver operator curve value was 0.85 on both databases. The scores were well calibrated in CPRD.
CONCLUSIONS: Each of the algorithms performed practically as well in the external independent CPRD validation cohorts as they had in the original published QResearch validation cohorts.},
	language = {eng},
	number = {8},
	journal = {BMJ open},
	author = {Hippisley-Cox, Julia and Coupland, Carol and Brindle, Peter},
	year = {2014},
	pmid = {25168040},
	pmcid = {PMC4156807},
	keywords = {Adult, Aged, Aged, 80 and over, Algorithms, Calibration, Cardiovascular Diseases, Cprd, Ethnic Groups, Family, Female, General Practice, Hemorrhage, Humans, Kidney Diseases, Male, Middle Aged, Osteoporotic Fractures, Prognosis, Prospective Studies, QResearch, Qrisk2, Risk, Validation, Venous Thromboembolism, diabetes mellitus},
	pages = {e005809}
}

@article{gawri_link_2014,
	title = {Link {N} is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity},
	volume = {32},
	issn = {1554-527X},
	doi = {10.1002/jor.22653},
	abstract = {Presently, there are no established treatments to prevent, stop or even retard back pain arising from disc degeneration. Previous studies have shown that Link N can act as a growth factor and stimulate the synthesis of proteoglycans and collagens, in IVD. However, the sequences in Link N involved in modulating cellular activity are not well understood. To determine if disc cells can proteolytically process Link N, human disc cells were exposed to native Link N over a 48 h period and mass spectrometric analysis revealed that a peptide spanning residues 1-8 was generated in the presence of AF cells but not NP cells. Link N 1-8 significantly induced proteoglycan production in the presence of IL-1β NP and AF cells, confirming that the biological effect is maintained in the first 8 amino acids of the peptide and indicating that the effect is sustained in an inflammatory environment. Thus Link-N 1-8 could be a promising candidate for biologically induced disc repair, and the identification of such a stable specific peptide may facilitate the design of compounds to promote disc repair and provide alternatives to surgical intervention for early stage disc degeneration.},
	language = {eng},
	number = {9},
	journal = {Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society},
	author = {Gawri, Rahul and Ouellet, Jean and Önnerfjord, Patrik and Alkhatib, Bashar and Steffen, Thomas and Heinegård, Dick and Roughley, Peter and Antoniou, John and Mwale, Fackson and Haglund, Lisbet},
	month = sep,
	year = {2014},
	pmid = {24861010},
	keywords = {Adolescent, Adult, Amino Acid Sequence, Animals, Biological Factors, Cattle, Cells, Cultured, Collagen, Female, Humans, IVD degeneration and regeneration, Intercellular Signaling Peptides and Proteins, Intervertebral Disc, Intervertebral Disc Degeneration, Link N, Lumbar Vertebrae, Male, Middle Aged, Molecular Sequence Data, Peptide Fragments, Proteoglycans, Regeneration, Thoracic Vertebrae, Young Adult, biological repair, organ culture},
	pages = {1189--1197},
}

@article{
 title = {How much do residential aged care staff members know about the nutritional needs of residents?},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Attitude of Health Personnel,Cross-Sectional Studies,Dementia/nursing,Female,Geriatric Nursing/methods,Health Care Surveys,Health Knowledge, Attitudes, Practice,Humans,Male,Malnutrition/nursing,Meals,Middle Aged,Nursing Staff,Nutrition Assessment,Quality of Life/psychology,Residential Facilities,malnutrition,mealtime practices,nutrition knowledge,old age,residential care,staff},
 pages = {54-64},
 volume = {9},
 month = {3},
 publisher = {Blackwell Publishing Ltd},
 city = {Dementia Collaborative Research Centre: Carers & Consumers, Queensland University of Technology, Brisbane, Australia; Dementia Training Studies Centre, Queensland University of Technology, Brisbane, Australia; School of Nursing, Queensland University of T},
 id = {ddcbb97d-cbf9-341d-982c-c02ae2ebd52c},
 created = {2016-08-20T16:52:30.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 74113; CI: (c) 2013; JID: 101267281; OTO: NOTNLM; 2012/08/03 [received]; 2012/11/21 [accepted]; 2013/02/11 [aheadofprint]; ppublish},
 folder_uuids = {06271a48-ad48-43cc-b073-52e57f10f5e1},
 private_publication = {false},
 abstract = {BACKGROUND: Undernutrition, weight loss and dehydration are major clinical issues for people with dementia in residential care, with excessive weight loss contributing to increased risk of frailty, immobility, illness and premature morbidity. This paper discusses a nutritional knowledge and attitudes survey conducted as part of a larger project focused on improving nutritional intake of people with dementia within a residential care facility in Brisbane, Australia. AIMS: The specific aims of the survey were to identify (i) knowledge of the nutritional needs of aged care facility residents; (ii) mealtime practices; and (iii) attitudes towards mealtime practices and organisation. METHODS: A survey based on those used in other healthcare settings was completed by 76 staff members. The survey included questions about nutritional knowledge, opinions of the food service, frequency of feeding assistance provided and feeding assessment practices. RESULTS: Nutritional knowledge scores ranged from 1 to 9 of a possible 10, with a mean score of 4.67. While 76% of respondents correctly identified risk factors associated with malnutrition in nursing home residents, only 38% of participants correctly identified the need for increased protein and energy in residents with pressure ulcers, and just 15% exhibited correct knowledge of fluid requirements. Further, while nutritional assessment was considered an important part of practice by 83% of respondents, just 53% indicated that they actually carried out such assessments. Identified barriers to promoting optimal nutrition included insufficient time to observe residents (56%); being unaware of residents' feeding issues (46%); poor knowledge of nutritional assessments (44%); and unappetising appearance of food served (57%). CONCLUSION: An important step towards improving health and quality of life for residents of aged care facilities would be to enhance staff nutritional awareness and assessment skills. This should be carried out through increased attention to both preservice curricula and on-the-job training. IMPLICATIONS FOR PRACTICE: The residential facility staff surveyed demonstrated low levels of nutrition knowledge, which reflects findings from the international literature. This has implications for the provision of responsive care to residents of these facilities and should be explored further.},
 bibtype = {article},
 author = {Beattie, E and O'Reilly, M and Strange, E and Franklin, S and Isenring, E},
 journal = {International journal of older people nursing},
 number = {1}
}

@article{jhunjhunwala_profile_2014,
	title = {Profile of extrapyramidal manifestations in 85 patients with spinocerebellar ataxia type 1, 2 and 3.},
	volume = {21},
	copyright = {Copyright (c) 2013 Elsevier Ltd. All rights reserved.},
	issn = {1532-2653 0967-5868},
	doi = {10.1016/j.jocn.2013.10.021},
	abstract = {This study aimed to determine the prevalence and type of extrapyramidal signs (EPS) in spinocerebellar ataxia (SCA) type 1, 2 and 3. Eighty-five patients with genetically confirmed SCA (SCA1=40, SCA2=28, SCA3=17) were evaluated for the prevalence and types of EPS. Forty-one SCA patients (48.2\%) had one or more types of EPS. The prevalence of EPS was 60.7\% in SCA2, 52.9\% in SCA3, and 37.5\% in SCA1. Among SCA2 patients, bradykinesia was the most frequent (35.3\%), followed by reduced facial expression, postural tremor and dystonia (29.4\% each), rest tremor, titubation and rigidity (23.5\% each), and lip/jaw tremor and chorea (11.8\% each). In SCA3 the common EPS were bradykinesia (44.4\%), staring look, postural tremor and dystonia (33.3\% each), and reduced facial expression and rigidity (22.2\% each). In SCA1, staring look was the most common (53.3\%), followed by dystonia and bradykinesia (33.3\% each), and postural tremor (26.7\%). In all three groups, there was no significant difference in the mean length of repeat of the abnormal allele between those with and without EPS. To conclude bradykinesia, staring look, dystonia and postural tremor were the most frequent EPS observed in SCA. In SCA1, these signs were seen more often in younger patients with early onset of symptoms.},
	language = {eng},
	number = {6},
	journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
	author = {Jhunjhunwala, Ketan and Netravathi, M. and Purushottam, Meera and Jain, Sanjeev and Pal, Pramod Kumar},
	month = jun,
	year = {2014},
	pmid = {24602359},
	note = {Place: Scotland},
	keywords = {*Alleles, Adult, Basal Ganglia Diseases/*diagnosis/epidemiology/*genetics, Cohort Studies, Dystonia, Extrapyramidal signs, Female, Humans, Male, Middle Aged, Movement disorders, Parkinsonism, Spinocerebellar Ataxias/*diagnosis/epidemiology/*genetics, Spinocerebellar ataxia, Tremor, Young Adult},
	pages = {1002--1006},
}

@article{vytal_sustained_2014,
	title = {Sustained anxiety increases amygdala-dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults.},
	volume = {39},
	copyright = {All rights reserved},
	issn = {1488-2434 1180-4882},
	doi = {10.1503/jpn.130145},
	abstract = {BACKGROUND: Neuroimaging research has traditionally explored fear and anxiety in response to discrete threat cues (e.g., during fear conditioning). However,  anxiety is a sustained aversive state that can persist in the absence of discrete  threats. Little is known about mechanisms that maintain anxiety states over a  prolonged period. Here, we used a robust translational paradigm (threat of shock)  to induce sustained anxiety. Recent translational work has implicated an  amygdala-prefrontal cortex (PFC) circuit in the maintenance of anxiety in  rodents. To explore the functional homologues of this circuitry in humans, we  used a novel paradigm to examine the impact of sustained anticipatory anxiety on  amygdala-PFC intrinsic connectivity. METHODS: Task-independent fMRI data were  collected in healthy participants during long-duration periods of shock  anticipation and safety. We examined intrinsic functional connectivity. RESULTS:  Our study involved 20 healthy participants. During sustained anxiety, amygdala  activity was positively coupled with dorsomedial PFC (DMPFC) activity. High trait  anxiety was associated with increased amygdala-DMPFC coupling. In addition,  induced anxiety was associated with positive coupling between regions involved in  defensive responding, and decreased coupling between regions involved in  emotional control and the default mode network. LIMITATIONS: Inferences regarding  anxious pathology should be made with caution because this study was conducted in  healthy participants. CONCLUSION: Findings suggest that anticipatory anxiety  increases intrinsic amygdala-DMPFC coupling and that the DMPFC may serve as a  functional homologue for the rodent prefrontal regions by sustaining anxiety.  Future research may use this defensive neural context to identify biomarkers of  risk for anxious pathology and target these circuits for therapeutic  intervention.},
	language = {eng},
	number = {5},
	journal = {Journal of psychiatry \& neuroscience : JPN},
	author = {Vytal, Katherine E. and Overstreet, Cassie and Charney, Danielle R. and Robinson, Oliver J. and Grillon, Christian},
	month = sep,
	year = {2014},
	pmid = {24886788},
	pmcid = {PMC4160361},
	note = {Place: Canada},
	keywords = {Adult, Amygdala/*physiopathology, Anticipation, Anticipation, Psychological/physiology, Anxiety/*physiopathology, Brain Mapping, Electroshock, Fear/physiology, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways/physiopathology, Neuropsychological Tests, Personality, Prefrontal Cortex/*physiopathology, Psychological/physiology, Psychophysics, Young Adult},
	pages = {321--329},
}

@article{taylor_all-cause_2013,
	title = {All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large {U}.{K}. primary care database},
	volume = {36},
	issn = {1935-5548},
	doi = {10.2337/dc12-1513},
	abstract = {OBJECTIVE: Middle-aged people with diabetes have been reported to have significantly higher risks of cardiovascular events than people without diabetes. However, recent falls in cardiovascular disease rates and more active management of risk factors may have abolished the increased risk. We aimed to provide an up-to-date assessment of the relative risks associated with type 2 diabetes of all-cause and cardiovascular mortality in middle-aged people in the U.K.
RESEARCH DESIGN AND METHODS: Using data from the General Practice Research Database, from 2004 to 2010, we conducted a cohort study of 87,098 people, 40-65 years of age at baseline, comparing 21,798 with type 2 diabetes and 65,300 without diabetes, matched on age, sex, and general practice. We produced hazard ratios (HRs) for mortality and compared rates of blood pressure testing, cholesterol monitoring, and use of aspirin, statins, and antihypertensive drugs. RESULTS People with type 2 diabetes, compared with people without diabetes, had a twofold increased risk of all-cause mortality (HR 2.07 [95\% CI 1.95-2.20], adjusted for smoking) and a threefold increased risk of cardiovascular mortality (3.25 [2.87-3.68], adjusted for smoking). Women had a higher relative risk than men, and people {\textless}55 years of age had a higher relative risk than those {\textgreater}55 years of age. Monitoring and medication rates were higher in those with diabetes (all P {\textless} 0.001).
CONCLUSIONS: Despite efforts to manage risk factors, administer effective treatments, and develop new therapies, middle-aged people with type 2 diabetes remain at significantly increased risk of death.},
	language = {eng},
	number = {8},
	journal = {Diabetes Care},
	author = {Taylor, Kathryn S. and Heneghan, Carl J. and Farmer, Andrew J. and Fuller, Alice M. and Adler, Amanda I. and Aronson, Jeffrey K. and Stevens, Richard J.},
	month = aug,
	year = {2013},
	pmid = {23435157},
	pmcid = {PMC3714501},
	keywords = {Adult, Cardiovascular Diseases, Cause of Death, Databases, Factual, Diabetes Mellitus, Type 2, Female, Great Britain, Humans, Male, Middle Aged, Risk, Sex Factors},
	pages = {2366--2371}
}

Paper  doi  abstract   bibtex   

@article{bourne_neuropsychological_2013,
	title = {Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis.},
	volume = {128},
	issn = {1600-0447},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23617548},
	doi = {10.1111/acps.12133},
	abstract = {OBJECTIVE: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view.

METHOD: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task.

RESULTS: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression.

CONCLUSION: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.},
	number = {3},
	urldate = {2015-05-01},
	journal = {Acta psychiatrica Scandinavica},
	author = {Bourne, C and Aydemir, Ö and Balanzá-Martínez, V and Bora, E and Brissos, S and Cavanagh, J T O and Clark, L and Cubukcuoglu, Z and Dias, V V and Dittmann, S and Ferrier, I N and Fleck, D E and Frangou, S and Gallagher, P and Jones, L and Kieseppä, T and Martínez-Aran, A and Melle, I and Moore, P B and Mur, M and Pfennig, A and Raust, A and Senturk, V and Simonsen, C and Smith, D J and Bio, D S and Soeiro-de-Souza, M G and Stoddart, S D R and Sundet, K and Szöke, A and Thompson, J M and Torrent, C and Zalla, T and Craddock, N and Andreassen, O A and Leboyer, M and Vieta, E and Bauer, M and Worhunsky, P D and Tzagarakis, C and Rogers, R D and Geddes, J R and Goodwin, G M},
	month = sep,
	year = {2013},
	pmid = {23617548},
	keywords = {Adult, Affect, Affective Symptoms, Affective Symptoms: psychology, Age of Onset, Bipolar Disorder, Bipolar Disorder: complications, Bipolar Disorder: diagnosis, Bipolar Disorder: drug therapy, Bipolar Disorder: epidemiology, Cognition Disorders, Cognition Disorders: diagnosis, Cognition Disorders: drug therapy, Cognition Disorders: epidemiology, Cognition Disorders: etiology, Confounding Factors (Epidemiology), Female, Humans, Male, Mental Competency, Mental Processes, Mental Processes: drug effects, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychotropic Drugs, Psychotropic Drugs: administration \& dosage, Psychotropic Drugs: adverse effects, Risk Factors},
	pages = {149--62},
}

@article{zhang_visible_2013,
	title = {Visible and near-infrared spectroscopy for distinguishing malignant tumor tissue from benign tumor and normal breast tissues in vitro},
	volume = {18},
	issn = {1560-2281},
	doi = {10.1117/1.JBO.18.7.077003},
	abstract = {The high incidence and mortality of breast cancer requires an effective, rapid, and cost-effective method for its diagnosis. Here, visible and near-infrared spectroscopy in the wavelength range of 400 to 2200 nm is utilized for distinguishing the malignant tumor tissue from benign tumor and normal breast tissues. Based on the absorption and scattering spectra of fixed samples, three spectral analysis methods are proposed which include an absorption spectral analysis, a scattering spectral analysis, and a combined spectral analysis of the two. By comparison with the histopathological examination, the sensitivity, specificity, and accuracy of the three analysis methods are calculated. The results showed that the combined spectral analysis method can significantly enhance the effectiveness when compared with the sole absorption or scattering spectral analysis method. The sensitivity, specificity, and accuracy of the combined spectral analysis method are 100\%, 87.82\%, and 87.50\% for the benign tumor tissue and 81.82\%, 100\%, and 87.5\% for malignant tumor tissue, respectively. All of the three values are 100\% for normal breast tissue. This study demonstrates that the combined spectral analysis method has better potential for in vitro optical diagnosis for breast lesions.},
	language = {eng},
	number = {7},
	journal = {Journal of Biomedical Optics},
	author = {Zhang, Yang and Chen, Yongjun and Yu, Yuan and Xue, Xingbo and Tuchin, Valery V. and Zhu, Dan},
	month = jul,
	year = {2013},
	pmid = {23839487},
	keywords = {Absorption, Breast, Breast Neoplasms, Female, Humans, Image Processing, Computer-Assisted, Reference Values, Scattering, Radiation, Sensitivity and Specificity, Spectroscopy, Near-Infrared},
	pages = {077003},
}

Paper  doi  abstract   bibtex   

@article{sollie_comparison_2013,
	title = {Comparison of mother, father, and teacher reports of {ADHD} core symptoms in a sample of child psychiatric outpatients.},
	volume = {17},
	issn = {1557-1246},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22441890},
	doi = {10.1177/1087054711436010},
	abstract = {OBJECTIVE: To explore the significance of adding father ratings to mother and teacher ratings in the assessment of ADHD symptoms in children.

METHOD: The ADHD Rating Scale-IV, the Child Behavior Checklist, and the Teacher Report Form were filled out by all three informants for a sample of 48 clinically referred children (79\% boys) aged 6 to 15 (M = 10.1) years.

RESULTS: Correspondence between father and teacher reports on ADHD-specific symptoms (intraclass correlation coefficient [ICC] = .38) exceeded that between mothers and teachers (ICC = .23). Fathers rated their children as having fewer problems than did mothers and teachers on Total scale scores and the Inattention subscale of the ADHD Rating Scale-IV. Mother ratings were more sensitive to an ADHD diagnosis, whereas father ratings better predicted an ADHD diagnosis requiring the two-setting criterion.

CONCLUSION: The choice of parent informant and informant combination had a considerable impact on parent-teacher concordance and estimates of ADHD symptoms and subtypes in the child.},
	number = {8},
	urldate = {2015-05-12},
	journal = {Journal of attention disorders},
	author = {Sollie, Henrik and Larsson, Bo and Mørch, Willy-Tore},
	month = nov,
	year = {2013},
	pmid = {22441890},
	keywords = {Adolescent, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: dia, Child, Faculty, Fathers, Female, Humans, Male, Mothers, Outpatients, Outpatients: psychology, Symptom Assessment},
	pages = {699--710},
}

Paper  doi  bibtex   

@article{robinson_role_2013,
	title = {The role of serotonin in the neurocircuitry of negative affective bias: {Serotonergic} modulation of the dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit},
	volume = {78},
	copyright = {All rights reserved},
	issn = {1053-8119},
	shorttitle = {The role of serotonin in the neurocircuitry of negative affective bias: {Serotonergic} modulation of the dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit},
	url = {http://www.sciencedirect.com/science/article/pii/S1053811913003303},
	doi = {10.1016/j.neuroimage.2013.03.075},
	journal = {Neuroimage},
	author = {Robinson, Oliver J. and Overstreet, Cassie and Allen, Philip S. and Letkiewicz, Alison and Vytal, Katherine and Pine, Daniel S. and Grillon, Christian},
	year = {2013},
	note = {0},
	keywords = {ATD, Adult, Affect/drug effects/physiology, Affective Symptoms, Amygdala, Amygdala/*metabolism/physiopathology, Anxiety/metabolism/physiopathology, Aversive amplification, Bias, Computer-Assisted, Cross-Over Studies, DMPFC, Depression/metabolism/physiopathology, Double-Blind Method, Emotions/drug effects/physiology, Female, Humans, Image Interpretation, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Negative bias, Neural Pathways/*metabolism/physiopathology, Prefrontal Cortex/*metabolism/physiopathology, Serotonin Receptor Agonists/pharmacology, Serotonin/*metabolism, Tryptophan/pharmacology, serotonin},
	pages = {217--223},
}

@article{thompson_epidemiological_2013,
	title = {Epidemiological features and risk factors of {Salmonella} gastroenteritis in children resident in {Ho} {Chi} {Minh} {City}, {Vietnam}.},
	volume = {141},
	issn = {1469-4409 0950-2688},
	doi = {10.1017/S0950268812002014},
	abstract = {Non-typhoidal Salmonella are an important but poorly characterized cause of paediatric diarrhoea in developing countries. We conducted a hospital-based case-control study in children aged {\textless}5 years in Ho Chi Minh City to define the epidemiology and examine risk factors associated with Salmonella diarrhoeal infections. From 1419 diarrhoea cases and 571 controls enrolled between 2009 and  2010, 77 (54\%) diarrhoea cases were stool culture-positive for non-typhoidal Salmonella. Salmonella patients were more likely to be younger than controls (median age 10 and 12 months, respectively) [odds ratio (OR) 097; 95\% confidence  interval (CI) 094-099], to report a recent diarrhoeal contact (81\% cases, 18\% controls; OR 598, 95\% CI 18-204) and to live in a household with {\textgreater}2 children (cases 208\%, controls 102\%; OR 232, 95\% CI 12-47). Our findings indicate that Salmonella are an important cause of paediatric gastroenteritis in this setting and we suggest that transmission may occur through direct human contact in the home.},
	language = {eng},
	number = {8},
	journal = {Epidemiology and infection},
	author = {Thompson, C. N. and Phan, V. T. M. and Le, T. P. T. and Pham, T. N. T. and Hoang, L. P. and Ha, V. and Nguyen, V. M. H. and Pham, V. M. and Nguyen, T. V. and Cao, T. T. and Tran, T. T. N. and Nguyen, T. T. H. and Dao, M. T. and Campbell, J. I. and Nguyen, T. C. and Tang, C. T. and Ha, M. T. and Farrar, J. and Baker, S.},
	month = aug,
	year = {2013},
	pmid = {23010148},
	pmcid = {PMC3733064},
	keywords = {*Developing Countries, Bacterial Typing Techniques, Case-Control Studies, Child, Preschool, Diarrhea/*epidemiology/microbiology, Feces/microbiology, Female, Gastroenteritis/*epidemiology/microbiology, Humans, Infant, Male, Prevalence, Risk Factors, Salmonella Infections/*epidemiology/microbiology/transmission, Salmonella/*isolation \& purification, Surveys and Questionnaires, Urban Population, Vietnam/epidemiology},
	pages = {1604--1613},
}

@article{cameron_development_2013,
	title = {The development of scientific communication skills: a qualitative study of the perceptions of trainees and their mentors},
	volume = {88},
	issn = {1938-808X},
	shorttitle = {The development of scientific communication skills},
	doi = {10.1097/ACM.0b013e3182a34f36},
	abstract = {PURPOSE: Scientific communication, both written and oral, is the cornerstone of success in biomedical research, yet formal instruction is rarely provided. Trainees with little exposure to standard academic English may find developing scientific communication skills challenging. In this exploratory, hypothesis-generating qualitative study, the authors examined the process by which mentored junior researchers learn scientific communication skills, their feelings about the challenges, and their mentor's role in the process.
METHOD: In 2010, the authors conducted semistructured focus groups and interviews to explore research trainees' and faculty mentors' perceptions and practices regarding scientific communication skills development, as part of the development phase of a larger quantitative study. The facilitator took detailed notes and verified their accuracy with participants during the sessions; a second member of the research team observed and verified the recorded notes. Three coders performed a thematic analysis, and the other authors reviewed it.
RESULTS: Forty-three trainees and 50 mentors participated. Trainees and mentors had diverging views on the role of mentoring in fostering communication skills development. Trainees expressed varying levels of self-confidence but considerable angst. Mentors felt that most trainees have low self-confidence. Trainees expressed interest in learning scientific communication skills, but mentors reported that some trainees were insufficiently motivated and seemed resistant to guidance. Both groups agreed that trainees found mentors' feedback difficult to accept.
CONCLUSIONS: The degree of distress, dissatisfaction, and lack of mutual understanding between mentors and trainees was striking. These themes have important implications for best practices and resource development.},
	language = {eng},
	number = {10},
	journal = {Academic Medicine: Journal of the Association of American Medical Colleges},
	author = {Cameron, Carrie and Collie, Candice L. and Baldwin, Constance D. and Bartholomew, L. Kay and Palmer, J. Lynn and Greer, Marilyn and Chang, Shine},
	month = oct,
	year = {2013},
	pmid = {23969363},
	pmcid = {PMC3809893},
	keywords = {Adult, Biomedical Research, Communication, Female, Focus Groups, Humans, Interviews as Topic, Language, Male, Mentors, Perception, Qualitative Research, Research Personnel},
	pages = {1499--1506},
}

@article{
 title = {Rates of medical errors and preventable adverse events among hospitalized children following implementation of a resident handoff bundle},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Boston,Child,Child, Hospitalized,Communication,Electronic Health Records,Female,Hospitals, Pediatric,Humans,Internship and Residency,Intervention Studies,Male,Medical Errors/prevention & control,Patient Admission,Patient Care Team,Patient Handoff/standards,Prospective Studies,Workload},
 pages = {2262-2270},
 volume = {310},
 month = {12},
 day = {4},
 city = {Division of General Pediatrics, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts2Doernbecher Children's Hospital, Oregon Health and Science University, Portland.},
 id = {018db06d-f7e0-3911-8657-5e153547e9fc},
 created = {2016-08-21T22:18:53.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 67732; GR: 1K12HS019456-01/HS/AHRQ HHS/United States; GR: T32 HP10018/PHS HHS/United States; GR: UL1TR000128/TR/NCATS NIH HHS/United States; JID: 7501160; CIN: JAMA. 2013 Dec 4;310(21):2255-6. PMID: 24302086; ppublish},
 folder_uuids = {4da8a58e-a2c5-4458-a19c-93e568b77eb4,4481d550-f7a1-48e7-874d-7663267b606b},
 private_publication = {false},
 abstract = {IMPORTANCE: Handoff miscommunications are a leading cause of medical errors. Studies comprehensively assessing handoff improvement programs are lacking. OBJECTIVE: To determine whether introduction of a multifaceted handoff program was associated with reduced rates of medical errors and preventable adverse events, fewer omissions of key data in written handoffs, improved verbal handoffs, and changes in resident-physician workflow. DESIGN, SETTING, AND PARTICIPANTS: Prospective intervention study of 1255 patient admissions (642 before and 613 after the intervention) involving 84 resident physicians (42 before and 42 after the intervention) from July-September 2009 and November 2009-January 2010 on 2 inpatient units at Boston Children's Hospital. INTERVENTIONS: Resident handoff bundle, consisting of standardized communication and handoff training, a verbal mnemonic, and a new team handoff structure. On one unit, a computerized handoff tool linked to the electronic medical record was introduced. MAIN OUTCOMES AND MEASURES: The primary outcomes were the rates of medical errors and preventable adverse events measured by daily systematic surveillance. The secondary outcomes were omissions in the printed handoff document and resident time-motion activity. RESULTS: Medical errors decreased from 33.8 per 100 admissions (95% CI, 27.3-40.3) to 18.3 per 100 admissions (95% CI, 14.7-21.9; P < .001), and preventable adverse events decreased from 3.3 per 100 admissions (95% CI, 1.7-4.8) to 1.5 (95% CI, 0.51-2.4) per 100 admissions (P = .04) following the intervention. There were fewer omissions of key handoff elements on printed handoff documents, especially on the unit that received the computerized handoff tool (significant reductions of omissions in 11 of 14 categories with computerized tool; significant reductions in 2 of 14 categories without computerized tool). Physicians spent a greater percentage of time in a 24-hour period at the patient bedside after the intervention (8.3%; 95% CI 7.1%-9.8%) vs 10.6% (95% CI, 9.2%-12.2%; P = .03). The average duration of verbal handoffs per patient did not change. Verbal handoffs were more likely to occur in a quiet location (33.3%; 95% CI, 14.5%-52.2% vs 67.9%; 95% CI, 50.6%-85.2%; P = .03) and private location (50.0%; 95% CI, 30%-70% vs 85.7%; 95% CI, 72.8%-98.7%; P = .007) after the intervention. CONCLUSIONS AND RELEVANCE: Implementation of a handoff bundle was associated with a significant reduction in medical errors and preventable adverse events among hospitalized children. Improvements in verbal and written handoff processes occurred, and resident workflow did not change adversely.},
 bibtype = {article},
 author = {Starmer, A J and Sectish, T C and Simon, D W and Keohane, C and McSweeney, M E and Chung, E Y and Yoon, C S and Lipsitz, S R and Wassner, A J and Harper, M B and Landrigan, C P},
 journal = {JAMA : the journal of the American Medical Association},
 number = {21}
}

Paper  doi  abstract   bibtex   

@article{burgess_does_2012,
	title = {Does stereotype threat affect women in academic medicine?},
	volume = {87},
	issn = {1938-808X},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3315611&tool=pmcentrez&rendertype=abstract},
	doi = {10.1097/ACM.0b013e318248f718},
	abstract = {Multiple complex factors contribute to the slow pace of women's advancement into leadership positions in academic medicine. In this article, the authors propose that stereotype threat–under which individuals who are members of a group characterized by negative stereotypes in a particular domain perform below their actual abilities in that domain when group membership is emphasized–may play an important role in the underrepresentation of women in leadership positions in academic medicine. Research to objectively assess the impact of stereotype threat for women in academic medicine is feasible and necessary to confirm this hypothesis. Still, a number of conditions present in the academic medicine community today have been shown to trigger stereotype threat in other settings, and stereotype threat fits with existing research on gender in academic medicine. In the meantime, academic health centers should implement relatively simple measures supported by experimental evidence from other settings to reduce the risk of stereotype threat, including (1) introducing the concept of stereotype threat to the academic medicine community, (2) engaging all stakeholders, male and female, to promote identity safety by enacting and making faculty aware of policies to monitor potential instances of discrimination, and training faculty to provide performance feedback that is free of gender bias, (3) counteracting the effects of sex segregation at academic health centers by increasing exposure to successful female leaders, (4) reducing gender stereotype priming by avoiding stereotypically male criteria for promotion, grants, and awards, and (5) building leadership efficacy among female physicians and scientists.},
	number = {4},
	journal = {Academic Medicine},
	author = {Burgess, Diana Jill and Joseph, Anne and van Ryn, Michelle and Carnes, Molly},
	month = apr,
	year = {2012},
	pmid = {22361794},
	keywords = {Academic Medical Centers, Academic Medical Centers: organization \& administr, Achievement, Faculty, Female, Humans, Leadership, Male, Prejudice, Stereotyping, Women's Rights, medical, physicians, women},
	pages = {506--12},
}

Website  abstract   bibtex   

@article{
 title = {Quantitative evaluation of white matter tract DTI parameter changes in gliomas using nonlinear registration.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Anisotropy,Brain Mapping,Brain Mapping: methods,Brain Neoplasms,Brain Neoplasms: pathology,Computer-Assisted,Diffusion Magnetic Resonance Imaging,Diffusion Magnetic Resonance Imaging: methods,Female,Glioma,Glioma: pathology,Humans,Image Interpretation,Male,Middle Aged},
 pages = {2309-15},
 volume = {60},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22387173},
 month = {5},
 day = {1},
 id = {52c453a0-39cf-3063-98b2-f969182bb93f},
 created = {2014-02-21T01:56:21.000Z},
 accessed = {2014-01-28},
 file_attached = {false},
 profile_id = {c9197201-0e1b-30a7-a154-39d024463beb},
 last_modified = {2017-03-16T10:25:05.903Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Diffusion tensor imaging (DTI) has been used extensively to investigate white matter architecture in the brain. In the context of neurological disease, quantification of DTI data sets enables objective characterisation of the associated pathological changes. The aim of this study is to propose a method of evaluating DTI parameter changes in gliomas in the internal capsule using nonlinear registration to delineate the white matter and enable quantitative assessment of DTI derived parameters. 20 patients selected pre-operatively with probable grade 2 or grade 3 glioma on structural MRI along with ten normal volunteers were included in this study. DTI fractional anisotropy (FA) maps were used to define a common segmented FA skeleton that was projected back onto the original individual FA maps. Objective segment classification as normal or abnormal was achieved by comparison to prediction intervals of FA and mean diffusivity (MD) defined in normal subjects. The internal capsules of each patient were segmented into 10 regions of interest (ROI) with 20 and 16 segments across the group having significantly increased or decreased FA and MD values respectively. Seven glioma patients had abnormal DTI parameters in the internal capsule. We show that the classification of tract segments was consistent with disruption, oedema or compression. The results suggest that this method could be used to detect changes in eloquent white matter tracts in individual patients.},
 bibtype = {article},
 author = {Miller, P and Coope, D and Thompson, G and Jackson, A and Herholz, K},
 journal = {NeuroImage},
 number = {4}
}

Website  abstract   bibtex   

@article{
 title = {Blood/air distribution of volatile organic compounds (VOCs) in a nationally representative sample.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Air Pollutants,Air Pollutants: analysis,Air Pollutants: blood,Child,Chlorobenzenes,Chlorobenzenes: analysis,Chlorobenzenes: blood,Drinking Water,Environmental Monitoring,Female,Gas Chromatography-Mass Spectrometry,Humans,Linear Models,Male,Middle Aged,Multivariate Analysis,Nutrition Surveys,Questionnaires,Smoking,Smoking: blood,Solid Phase Microextraction,United States,Volatile Organic Compounds,Volatile Organic Compounds: analysis,Volatile Organic Compounds: blood,Young Adult},
 pages = {225-32},
 volume = {419},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22285084},
 publisher = {Elsevier B.V.},
 id = {33341907-add2-3a89-9999-74cba0377b37},
 created = {2015-03-09T20:40:30.000Z},
 file_attached = {true},
 profile_id = {03bdbf9c-0848-344e-95e3-9d552532f95c},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 folder_uuids = {94112c8a-2c34-4696-add4-3937d89cec61},
 private_publication = {false},
 abstract = {Volatile organic compounds (VOCs) in human blood are an effective biomarker of environmental exposure and are closely linked to health outcomes. Unlike VOC concentrations in air, which are routinely collected, blood VOC data are not as readily available. This study aims to develop the quantitative relationship between air and blood VOCs by deriving population-based blood/air distribution coefficients (popKs) of ten common VOCs in the general U.S. population. Air and human blood samples were collected from 364 adults aged 20-59 years in 1999-2000 National Health and Nutrition Examination Survey (NHANES). Determinants of popKs were identified using weighted multivariate regression models. In the non-smoking population, median popKs ranged from 3.1 to 77.3, comparable to values obtained in the laboratory. PopKs decreased with increasing airborne VOC concentrations. Smoking elevated popKs by 1.5-3.5 times for aromatic compounds, but did not affect the popKs for methyl tert-butyl ether (MTBE) or chlorinated compounds. Drinking water concentration was a modifier of MTBE's popK. Age, gender, body composition, nor ethnicity affected popKs. PopKs were predictable using linear models with air concentration as the independent variable for both adults and children. This is the first study to estimate blood/air distribution coefficients using simultaneous environmental and biological monitoring on a national population sample. This study was also the first to determine the blood/air distribution coefficient of p-dichlorobenzene, a compound frequently found in indoor environments. These results have applications in exposure assessment, pharmacokinetic analysis, physiologically-based pharmacokinetic (PBPK) modeling, and uncertainty analysis.},
 bibtype = {article},
 author = {Jia, Chunrong and Yu, Xinhua and Masiak, Wasim},
 journal = {The Science of the total environment}
}

Paper  doi  abstract   bibtex   

@article{hirai_distribution_2012,
	title = {Distribution of polybrominated diphenyl ethers in {Japanese} autopsy tissue and body fluid samples.},
	volume = {19},
	issn = {1614-7499},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22544599},
	doi = {10.1007/s11356-012-0915-z},
	abstract = {Brominated flame retardants are components of many plastics and are used in products such as cars, textiles, televisions, and personal computers. Human exposure to polybrominated diphenyl ether (PBDE) flame retardants has increased exponentially during the last three decades. Our objective was to measure the body burden and distribution of PBDEs and to determine the concentrations of the predominant PBDE congeners in samples of liver, bile, adipose tissue, and blood obtained from Japanese autopsy cases. Tissues and body fluids obtained from 20 autopsy cases were analyzed. The levels of 25 PBDE congeners, ranging from tri- to hexa-BDEs, were assessed. The geometric means of the sum of the concentrations of PBDE congeners having detection frequencies {\textbackslash}textgreater50 \% (ΣPBDE) in the blood, liver, bile, and adipose tissue were 2.4, 2.6, 1.4, and 4.3 ng/g lipid, respectively. The most abundant congeners were BDE-47 and BDE-153, followed by BDE-100, BDE-99, and BDE-28+33. These concentrations of PBDE congeners were similar to other reports of human exposure in Japan but were notably lower than concentrations than those reported in the USA. Significant positive correlations were observed between the concentrations of predominant congeners and ΣPBDE among the samples analyzed. The ΣPBDE concentration was highest in the adipose tissue, but PBDEs were distributed widely among the tissues and body fluids analyzed. The PBDE levels observed in the present study are similar to those reported in previous studies in Japan and significantly lower than those reported in the USA.},
	number = {8},
	journal = {Environmental science and pollution research international},
	author = {Hirai, Tetsuya and Fujimine, Yoshinori and Watanabe, Shaw and Nakano, Takeshi},
	month = sep,
	year = {2012},
	pmid = {22544599},
	keywords = {80 and over, Adipose Tissue, Adipose Tissue: chemistry, Adult, Aged, Asian Continental Ancestry Group, Bile, Bile: chemistry, Body Burden, Cadaver, Female, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Halogenated Diphenyl Ethers: blood, Humans, Liver, Liver: chemistry, Male, Middle Aged},
	pages = {3538--46},
}

@article{looker_lumbar_2012-1,
	title = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: {United} {States}, 2005-2008},
	issn = {0083-1980},
	shorttitle = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area},
	abstract = {OBJECTIVE: This report presents bone measurement data from dual-energy X-ray absorptiometry scans of the lumbar spine and proximal femur for persons aged 8 years and over from the National Health and Nutrition Examination Survey (NHANES) 2005-2008.
METHODS: Means, standard deviations, and selected percentiles were calculated for the proximal femur and lumbar spine (total and subregions) by sex, race and ethnicity, and age. Smoothed mean total lumbar spine and femur neck bone mineral density (BMD) were plotted by age, sex, and race and ethnicity. Multiple regression was used to test for significant interactions and to calculate mean total lumbar spine and femur neck BMD after adjusting for age, sex, and race and ethnicity. Differences by sex, race and ethnicity, and age were summarized by calculating the percent difference in adjusted means.
RESULTS: Among scanned individuals, 11\% lacked total lumbar spine data due to invalid data for one or more lumbar vertebrae, and 4\% had invalid data for the proximal femur. Non-Hispanic black persons had 6\% higher total lumbar spine BMD and 9\%-10\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD and femur neck BMD did not differ between Mexican-American and non-Hispanic white persons in those under age 20. For those aged 20 and over, Mexican-American persons had 4\% lower total lumbar spine BMD but 1\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD was 8\%-17\% higher in females aged 8-15 compared with males of the same age. In the age group 16-49, mean total lumbar spine BMD was similar or slightly higher for females compared with males, but after age 50 it was 60\%-15\% lower for females compared with males. Mean femur neck BMD was 5\%-13\% lower for females than males in all age groups except 12-15.},
	language = {eng},
	number = {251},
	journal = {Vital and Health Statistics. Series 11, Data from the National Health Survey},
	author = {Looker, Anne C. and Borrud, Lori G. and Hughes, Jeffery P. and Fan, Bo and Shepherd, John A. and Melton, L. Joseph},
	month = mar,
	year = {2012},
	pmid = {24261130},
	keywords = {Absorptiometry, Photon, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bone Density, Child, Ethnic Groups, Female, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Nutrition Surveys, Regression Analysis, Sex Factors, United States, Young Adult},
	pages = {1--132}
}

@article{ drackley_effect_2012,
  title = {Effect of massage therapy for postsurgical mastectomy recipients},
  volume = {16},
  issn = {1538-067X},
  doi = {10.1188/12.CJON.121-124},
  abstract = {This quality improvement pilot study evaluated the effect of massage therapy on pain, anxiety, and overall well-being in women who received mastectomies at a busy hospital practice. Participants reported a significant reduction in pain, stress, and muscle tension, as well as an increase in relaxation. Oncology nurses should consider the feasibility of massage therapy as a valuable nonpharmcologic pain management strategy.},
  language = {eng},
  number = {2},
  journal = {Clinical Journal of Oncology Nursing},
  author = {Drackley, Nancy L. and Degnim, Amy C. and Jakub, James W. and Cutshall, Susanne M. and Thomley, Barbara S. and Brodt, Julie K. and Vanderlei, Laura K. and Case, Jane K. and Bungum, Lisa D. and Cha, Stephen S. and Bauer, Brent A. and Boughey, Judy C.},
  month = {April},
  year = {2012},
  pmid = {22459520},
  keywords = {Anxiety, Breast Neoplasms, Evidence-Based Nursing, Female, Humans, Massage, Mastectomy, Pain, Patient Satisfaction, Pilot Projects},
  pages = {121--124}
}

@article{spoendlin_study_2012,
	title = {A study on the epidemiology of rosacea in the {U}.{K}},
	volume = {167},
	issn = {1365-2133},
	doi = {10.1111/j.1365-2133.2012.11037.x},
	abstract = {BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09\% to 22\%. To our knowledge, incidence rates have not been quantified before.
OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5\% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80\% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8\% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95\% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.},
	language = {eng},
	number = {3},
	journal = {The British Journal of Dermatology},
	author = {Spoendlin, J. and Voegel, J. J. and Jick, S. S. and Meier, C. R.},
	month = sep,
	year = {2012},
	pmid = {22564022},
	keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alcohol Drinking, Child, Child, Preschool, Diagnosis, Differential, Epidemiologic Methods, Female, Great Britain, Humans, Infant, Life Style, Male, Middle Aged, Rosacea, Smoking, Young Adult, incidence},
	pages = {598--605}
}

Paper  doi  bibtex   

@article{budzik_jf_diffusion_2011,
title = {Diffusion tensor imaging and fibre tracking in cervical spondylotic myelopathy},
volume = {21},
issn = {0938-7994},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20725834},
DOI = {10.1007/s00330-010-1927-z},
Language = {English},
Journal = {Eur. Radiol.},
author = {{Budzik JF} and {Balbi V} and {Le Thuc V} and {Duhamel A} and {Assaker R} and {Cotten A}},
year = {2011},
keywords = {Adult, Aged, Diffusion Tensor Imaging/methods*, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated/pathology*, Reproducibility of Results, Sensitivity and Specificity, Spinal Cord Compression/etiology*, Spinal Cord Compression/pathology*, Spondylosis/complications*, Spondylosis/pathology*},
pages = {426-433}
}

Paper  doi  abstract   bibtex   

@article{luchinger_eegbold_2011,
	title = {{EEG}–{BOLD} correlations during (post-) adolescent brain maturation},
	volume = {56},
	issn = {10538119},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21349336},
	doi = {10.1016/j.neuroimage.2011.02.050},
	abstract = {The transition from adolescence to adulthood is a critical stage in the human lifespan during which the brain still undergoes substantial structural and functional change. The changing frequency composition of the resting state EEG reflects maturation of brain function. This study investigated (post)adolescent brain maturation captured by two independently but simultaneously recorded neuronal signals: EEG and fMRI. Data were collected in a 20 min eyes-open/eyes-closed resting state paradigm. EEG, fMRI-BOLD signal and EEG-BOLD correlations were compared between groups of adults, age 25 (n=18), and adolescents, age 15 (n=18). A typical developmental decrease of low-frequency EEG power was observed even at this late stage of brain maturation. Frequency and condition specific EEG-fMRI correlations proved robust for multiple brain regions. However, no consistent change in the EEG-BOLD correlations was identified that would correspond to the neuronal maturation captured by the EEG. This result indicates that the EEG-BOLD correlation measures a distinct aspect of neurophysiological activity that presumably matures earlier, since it is less sensitive to late maturation than the neuronal activity captured by low-frequency EEG.},
	number = {3},
	urldate = {2015-04-10},
	journal = {NeuroImage},
	author = {Lüchinger, Rafael and Michels, Lars and Martin, Ernst and Brandeis, Daniel},
	month = jun,
	year = {2011},
	pmid = {21349336},
	keywords = {Adolescent, Adult, Aging, Aging: physiology, Alpha Rhythm, Alpha Rhythm: physiology, Brain, Brain: growth \& development, Data Interpretation, Delta Rhythm, Delta Rhythm: physiology, Electroencephalography, Female, Humans, Magnetic Resonance Imaging, Male, Models, Nerve Net, Nerve Net: growth \& development, Nerve Net: physiology, Neurological, Oxygen, Oxygen: blood, Photic Stimulation, Regression Analysis, Rest, Rest: physiology, Statistical, Theta Rhythm, Theta Rhythm: physiology, Young Adult},
	pages = {1493--1505},
}

@article{kelly_london_2011,
	title = {The {London} low emission zone baseline study},
	issn = {1041-5505},
	abstract = {On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter {\textless} or = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these suggested that the clearest signals of change were most likely to be measured near roadsides. The seven key areas were also likely to be of importance in carrying out a study to assess the health outcomes of an air quality intervention like the LEZ. Of the seven key areas, two already had monitoring sites with a full complement of equipment, four had monitoring sites that required upgrades of existing equipment, and one required a completely new installation. With the upgrades and new installations in place, fully ratified (verified) pollutant data (for PM10, PM with an aerodynamic diameter {\textless} or = 2.5 microm [PM2.5], nitrogen oxides [NOx], and ozone [O3] at all sites as well as for particle number, black smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites) were then collected for analysis. In addition, the seven key monitoring sites were supported by other sites in the London Air Quality Network (LAQN). From these, a robust set of baseline air quality data was produced. Data from automatic and manual traffic counters as well as automatic license-plate recognition cameras were used to compile detailed vehicle profiles. This enabled us to establish more precise associations between ambient pollutant concentrations and vehicle emissions. An additional goal of the study was to collect baseline PM data in order to test the hypothesis that changes in traffic densities and vehicle mixes caused by the LEZ would affect the oxidative potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM data set was the first to describe, in detail, the oxidative potential and metal content of the PM10 and PM2.5 of a major city's airshed. PM in London has considerable oxidative potential; clear differences in this measure were found from site to site, with evidence that the oxidative potential of both PM10 and PM2.5 at roadside monitoring sites was higher than at urban background locations. In the PM10 samples this increased oxidative activity appeared to be associated with increased concentrations of copper (Cu), barium (Ba), and bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. In the PM2.5 samples, no simple association could be seen, suggesting that other unmeasured components were driving the increased oxidative potential in this fraction of the roadside samples. These data suggest that two components were contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10 microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived for this baseline study confirmed key observations from a more limited spatial mapping exercise published in our earlier HEI report on the introduction of the London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In addition, the data set in the current report provided robust baseline information on the oxidative potential and metal content of PM found in the London airshed in the period before implementation of the LEZ; the finding that a proportion of the oxidative potential appears in the PM coarse mode and is apparently related to brake wear raises important issues regarding the nature of traffic management schemes. The final goal of this baseline study was to establish the feasibility, in ethical and operational terms, of using the U.K.'s electronic primary-care records to evaluate the effects of the LEZ on human health outcomes. Data on consultations and prescriptions were compiled from a pilot group of general practices (13 distributed across London, with 100,000 patients; 29 situated in the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals were obtained to link individual primary-care records to modeled NOx concentrations by means of post-codes. (To preserve anonymity, the postcodes were removed before delivery to the research team.) A wide range of NOx exposures was found across London as well as within and between the practices examined. Although we observed little association between NOx exposure and smoking status, a positive relationship was found between exposure and increased socioeconomic deprivation. The health outcomes we chose to study were asthma, chronic obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory tract infections, ischemic heart disease, heart failure, and atrial fibrillation. These outcomes were measured as prevalence or incidence. Their distributions by age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord with those reported in the epidemiology literature. No cross-sectional positive associations were found between exposure to NOx and any of the studied health outcomes; some associations were significantly negative. After the pilot study, a suitable primary-care database of London patients was identified, the General Practice Research Database responsible for giving us access to these data agreed to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring privacy of the records was agreed upon. The database included about 350,000 patients who had remained at the same address over the four-year period of the study. Power calculations for a controlled longitudinal analysis were then performed, indicating that for outcomes such as consultations for respiratory illnesses or prescriptions for asthma there was sufficient power to identify a 5\% to 10\% reduction in consultations for patients most exposed to the intervention compared with patients presumed to not be exposed to it. In conclusion, the work undertaken in this study provides a good foundation for future LEZ evaluations. Our extensive monitoring network, measuring a comprehensive set of pollutants (and a range of particle metrics), will continue to provide a valuable tool both for assessing the impact of LEZ regulations on air quality in London and for furthering understanding of the link between PM's composition and toxicity. Finally, we believe that in combination with our modeling of the predicted population-based changes in pollution exposure in London, the use of primary-care databases forms a sound basis and has sufficient statistical power for the evaluation of the potential impact of the LEZ on human health.},
	language = {eng},
	number = {163},
	journal = {Research Report (Health Effects Institute)},
	author = {Kelly, Frank and Armstrong, Ben and Atkinson, Richard and Anderson, H. Ross and Barratt, Ben and Beevers, Sean and Cook, Derek and Green, Dave and Derwent, Dick and Mudway, Ian and Wilkinson, Paul and {HEI Health Review Committee}},
	month = nov,
	year = {2011},
	pmid = {22315924},
	keywords = {Adolescent, Adult, Aged, Air Pollutants, Air Pollution, Child, Child, Preschool, Cross-Sectional Studies, Environmental Exposure, Environmental Monitoring, Female, Health Status, Humans, Infant, London, Longitudinal Studies, Male, Metals, Middle Aged, Nitrogen Oxides, Particulate Matter, Pilot Projects, Primary Health Care, Small-Area Analysis, Smoking, Socioeconomic Factors, Vehicle Emissions, Young Adult},
	pages = {3--79}
}

@article{kotz_incidence_2011,
	title = {Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in {England}, 2001 to 2005},
	volume = {127},
	issn = {1097-6825},
	doi = {10.1016/j.jaci.2010.11.021},
	abstract = {BACKGROUND: Previous descriptions of the epidemiology of peanut allergy have mainly been derived from small cross-sectional studies.
OBJECTIVE: To interrogate a large national research database to provide estimates for the incidence, prevalence, and trends of general practitioner (GP)-recorded diagnosis of peanut allergy in the English population.
METHODS: Version 10 of the QRESEARCH database was used with data from 2,958,366 patients who were registered with 422 United Kingdom general practices in the years 2001 to 2005. The primary outcome was a recording of clinician-diagnosed peanut allergy.
RESULTS: The age-sex standardized incidence rate of peanut allergy in 2005 was 0.08 per 1000 person-years (95\% CI, 0.07-0.08), and the prevalence rate was 0.51 per 1000 patients (95\% CI, 0.49-0.54). This translated into an estimated 4000 incident cases (95\% CI, 3500-4600) and 25,700 prevalent cases (95\% CI, 24,400-27,100) of GP-recorded diagnosis of peanut allergy in England in 2005. During the study period, the incidence rate of peanut allergy remained fairly stable, whereas the prevalence rate doubled. In those under 18 years of age, the crude lifetime prevalence rate was higher in males than females. A significant inverse relationship between prevalence and socioeconomic status was found.
CONCLUSION: These data on GP-recorded diagnosis of peanut allergy from a large general practice database suggest a much lower prevalence in peanut allergy than has hitherto been found. This difference may in part be explained by underrecording of peanut allergy in general practice. Further research is needed to assess the true frequency of peanut allergy in the population and whether there has been a true increase in recent years.},
	language = {eng},
	number = {3},
	journal = {The Journal of Allergy and Clinical Immunology},
	author = {Kotz, Daniel and Simpson, Colin R. and Sheikh, Aziz},
	month = mar,
	year = {2011},
	pmid = {21236479},
	keywords = {Adolescent, Adult, Child, Child, Preschool, England, Female, General Practitioners, Great Britain, Humans, Infant, Male, Medical Records, Peanut Hypersensitivity, Prevalence, incidence},
	pages = {623--630.e1}
}

@article{laumet_study_2010,
	title = {A study of the association between the {ADAM12} and {SH3PXD2A} ({SH3MD1}) genes and {Alzheimer}'s disease},
	volume = {468},
	issn = {1872-7972},
	doi = {10.1016/j.neulet.2009.10.040},
	abstract = {Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to beta-amyloid (Abeta) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Abeta. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.},
	language = {eng},
	number = {1},
	journal = {Neuroscience Letters},
	author = {Laumet, Geoffroy and Petitprez, Vincent and Sillaire, Adeline and Ayral, Anne-Marie and Hansmannel, Franck and Chapuis, Julien and Hannequin, Didier and Pasquier, Florence and Scarpini, Elio and Galimberti, Daniela and Lendon, Corinne and Campion, Dominique and Amouyel, Philippe and Lambert, Jean-Charles},
	month = jan,
	year = {2010},
	pmid = {19837132},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Genetic Predisposition to Disease, Risk Factors, Case-Control Studies, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Membrane Proteins, ADAM Proteins, ADAM12 Protein, Adaptor Proteins, Vesicular Transport},
	pages = {1--2}
}

@article{giudice_clinical_2010,
	title = {Clinical practice. {Endometriosis}},
	volume = {362},
	issn = {1533-4406},
	doi = {10.1056/NEJMcp1000274},
	language = {eng},
	number = {25},
	journal = {The New England Journal of Medicine},
	author = {Giudice, Linda C.},
	month = jun,
	year = {2010},
	pmid = {20573927},
	pmcid = {PMC3108065},
	keywords = {Dysmenorrhea, Dyspareunia, Endometriosis, Female, Humans, Infertility, Female, Pelvic Pain},
	pages = {2389--2398}
}

@article{may_peripheral_2010,
	title = {Peripheral biomarkers of endometriosis: a systematic review},
	volume = {16},
	issn = {1460-2369},
	shorttitle = {Peripheral biomarkers of endometriosis},
	doi = {10.1093/humupd/dmq009},
	abstract = {BACKGROUND: Endometriosis is estimated to affect 1 in 10 women during the reproductive years. There is often delay in making the diagnosis, mainly due to the non-specific nature of the associated symptoms and the need to verify the disease surgically. A biomarker that is simple to measure could help clinicians to diagnose (or at least exclude) endometriosis; it might also allow the effects of treatment to be monitored. If effective, such a marker or panel of markers could prevent unnecessary diagnostic procedures and/or recognize treatment failure at an early stage.
METHODS: We used QUADAS (Quality Assessment of Diagnostic Accuracy Studies) criteria to perform a systematic review of the literature over the last 25 years to assess critically the clinical value of all proposed biomarkers for endometriosis in serum, plasma and urine.
RESULTS: We identified over 100 putative biomarkers in publications that met the selection criteria. We were unable to identify a single biomarker or panel of biomarkers that have unequivocally been shown to be clinically useful.
CONCLUSIONS: Peripheral biomarkers show promise as diagnostic aids, but further research is necessary before they can be recommended in routine clinical care. Panels of markers may allow increased sensitivity and specificity of any diagnostic test.},
	language = {eng},
	number = {6},
	journal = {Human Reproduction Update},
	author = {May, K. E. and Conduit-Hulbert, S. A. and Villar, J. and Kirtley, S. and Kennedy, S. H. and Becker, C. M.},
	month = dec,
	year = {2010},
	pmid = {20462942},
	pmcid = {PMC2953938},
	keywords = {Antibodies, Apoptosis, Biomarkers, Cell Adhesion, Cytokines, Endometriosis, Female, Glycoproteins, Hormones, Humans, Intercellular Signaling Peptides and Proteins, Leukocytes, Proteomics, Vascular Endothelial Growth Factor A},
	pages = {651--674}
}

Paper  doi  abstract   bibtex   

@article{,
   abstract = {In the United States, cancer is the second most common cause of death and it is expected that about 562,340 Americans will have died of cancer in 2009. Bone cancer pain is common in patients with advanced breast, prostate, and lung cancer as these tumors have a remarkable affinity to metastasize to bone. Once tumors metastasize to bone, they are a major cause of morbidity and mortality as the tumor induces significant skeletal remodeling, fractures, pain, and anemia. Currently, the factors that drive cancer pain are poorly understood. However, several recently introduced models of bone cancer pain, which closely mirror the human condition, are providing insight into the mechanisms that drive bone cancer pain and guide the development of mechanism-based therapies to treat the cancer pain. Several of these mechanism-based therapies have now entered human clinical trials. If successful, these therapies have the potential to significantly enlarge the repertoire of modalities that can be used to treat bone cancer pain and improve the quality of life, functional status, and survival of patients with bone cancer. © 2010 New York Academy of Sciences.},
   author = {Juan Miguel Jimenez-Andrade and William G. Mantyh and Aaron P. Bloom and Alice S. Ferng and Christopher P. Geffre and Patrick W. Mantyh},
   doi = {10.1111/J.1749-6632.2009.05429.X},
   isbn = {9781573317788},
   issn = {1749-6632},
   journal = {Annals of the New York Academy of Sciences},
   keywords = {Acidosis / etiology,Animal,Animals,Bone Neoplasms / epidemiology,Bone Neoplasms / mortality,Bone Neoplasms / pathology,Bone Neoplasms / physiopathology*,Bone Neoplasms / secondary,Bone and Bones / pathology,Breast Neoplasms / complications,Disease Models,Female,Humans,Juan Miguel Jimenez-Andrade,Lung Neoplasms / complications,MEDLINE,Male,Mice,NCBI,NIH,NLM,National Center for Biotechnology Information,National Institutes of Health,National Library of Medicine,Neoplasm Metastasis / pathology,Osteoclasts / pathology,PMC5642911,Pain / etiology,Pain / physiopathology*,Patrick W Mantyh,Prostatic Neoplasms / complications,PubMed Abstract,Review,Sarcoma / pathology,United States / epidemiology,William G Mantyh,doi:10.1111/j.1749-6632.2009.05429.x,pmid:20536932},
   pages = {173-181},
   pmid = {20536932},
   publisher = {Ann N Y Acad Sci},
   title = {Bone cancer pain},
   volume = {1198},
   url = {https://pubmed.ncbi.nlm.nih.gov/20536932/},
   year = {2010},
}

Website  abstract   bibtex   

@article{
 title = {ERPs and neural oscillations during volitional supporession of memory retrieval},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Adolescent,Analysis of Variance,Association Learning,Association Learning: physiology,Biological Clocks,Biological Clocks: physiology,Brain,Brain Mapping,Brain: blood supply,Brain: physiology,Electroencephalography,Emotions,Emotions: physiology,Evoked Potentials,Evoked Potentials: physiology,Female,Humans,Image Processing, Computer-Assisted,Magnetic Resonance Imaging,Male,Mental Recall,Mental Recall: physiology,Oxygen,Oxygen: blood,Photic Stimulation,Reaction Time,Visual Perception,Young Adult},
 pages = {1-10},
 volume = {25},
 websites = {http://www.mitpressjournals.org/doi/abs/10.1162/jocn_a_00418#.Vgcwxo9Viko},
 month = {10},
 publisher = {MIT Press55 Hayward Street, Cambridge, MA 02142-1315USAjournals-info@mit.edu},
 day = {28},
 id = {9e3549f7-2c0d-33e4-84d8-bab5eb144557},
 created = {2015-09-27T00:17:34.000Z},
 accessed = {2015-09-26},
 file_attached = {false},
 profile_id = {50a856f4-e41b-3395-a32c-35f3a97eb9f9},
 group_id = {1d7f53de-0a60-3d99-b9ab-c9b479ac932e},
 last_modified = {2015-11-28T00:03:58.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Depue2010m},
 language = {en},
 abstract = {Although investigations of memory and the dynamics of ERP components and neural oscillations as assessed through EEG have been well utilized, little research into the volitional nature of suppression over memory retrieval have used these methods. Oscillation analyses conducted on the Think/No-Think (TNT) task and volitional suppression of retrieval are of interest to broaden our knowledge of neural oscillations associated not only during successful memory retrieval but also when retrieval is unwanted or suppressed. In the current study, we measured EEG during a TNT task and performed ERP and EEG spectral power band analyses. ERP results replicated other researchers' observations of increases in 500-800 msec parietal effects for items where retrieval was instructed to be elaborated compared with being suppressed. Furthermore, EEG analyses indicated increased alpha (8-12 Hz) and theta (3-8 Hz) oscillations across parietal electrodes for items that were instructed to be suppressed versus those to be elaborated. Additionally, during the second half of the experiment (after repeated attempts at control), increases in theta oscillations were found across both frontal and parietal electrodes for items that were instructed to be suppressed and that were ultimately forgotten versus those ultimately remembered. Increased alpha power for items that were instructed to be suppressed versus elaborated may indicate reductions of retrieval attempts or lack of retrieval success. Increased theta power for items that were instructed to be suppressed versus elaborated may indicate increased or prolonged cognitive control to monitor retrieval events.},
 bibtype = {article},
 author = {Depue, Brendan Eliot and Ketz, Nick and Mollison, Matthew V and Nyhus, Erika and Banich, Marie T and Curran, Tim},
 journal = {Journal of Cognitive Neuroscience},
 number = {10}
}

@article{hippisley-cox_individualising_2010,
	title = {Individualising the risks of statins in men and women in {England} and {Wales}: population-based cohort study},
	volume = {96},
	issn = {1468-201X},
	shorttitle = {Individualising the risks of statins in men and women in {England} and {Wales}},
	doi = {10.1136/hrt.2010.199034},
	abstract = {OBJECTIVE: To derive and validate risk algorithms so that the risks of four clinical outcomes associated with statin use can be estimated for individual patients.
DESIGN: Prospective open cohort study using routinely collected data from 368 QResearch general practices in England and Wales to develop the scores. The scores were validated using two separate sets of practices-188 separate QResearch practices and 364 practices contributing to the THIN database.
SUBJECTS: In the QResearch derivation cohort 225 922 new users of statins and 1 778 770 non-users of statins were studied. In the QResearch validation cohort 118 372 statin users and 877 812 non-users of statins were studied. In the THIN validation cohort, we studied 282 056 statin users and 1 923 840 non-users of statins were studied.
METHODS: Cox proportional hazards models in the derivation cohort to derive risk equations. Measures of calibration and discrimination in both validation cohorts.
OUTCOMES: 5-Year risk of moderate/serious myopathic events; moderate/serious liver dysfunction; acute renal failure and cataract.
RESULTS: The performance of three of the risk prediction algorithms in the THIN cohort was very good. For example, in women, the algorithm for moderate/serious myopathy explained 42.15\% of the variation. The corresponding D statistics was 1.75. The acute renal failure algorithm explained 59.62\% of the variation (D statistic=2.49). The cataract algorithm explained 59.14\% of the variation (D statistic=2.46). The algorithms to predict moderate/severe liver dysfunction only explained 15.55\% of the variation (D statistics=0.89). The performance of each algorithm was similar for both sexes when tested on the QResearch validation cohort.
CONCLUSIONS: The algorithms to predict acute renal failure, moderate/serious myopathy and cataract could be used to identify patients at increased risk of these adverse effects enabling patients to be monitored more closely. Further research is needed to develop a better algorithm to predict liver dysfunction.},
	language = {eng},
	number = {12},
	journal = {Heart (British Cardiac Society)},
	author = {Hippisley-Cox, Julia and Coupland, Carol},
	month = jun,
	year = {2010},
	pmid = {20489220},
	keywords = {Acute Kidney Injury, Adult, Aged, Aged, 80 and over, Algorithms, Body Mass Index, Cataract, Drug-Induced Liver Injury, England, Epidemiologic Methods, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Muscular Diseases, Wales},
	pages = {939--947}
}

Paper  doi  bibtex   

@article{tacelli_n_assessment_2010,
title = {Assessment of Non-Small Cell Lung Cancer Perfusion: Pathologic-CT Correlation in 15 Patients},
volume = {257},
issn = {0033-8419},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20843993},
DOI = {10.1148/radiol.10100181},
Language = {English},
Journal = {Radiology},
author = {{Tacelli N} and {Remy-Jardin M} and {Copin MC} and {Scherpereel A} and {Mensier E} and {Jaillard S} and {Lafitte JJ} and {Klotz E} and {Duhamel A} and {Remy J}},
year = {2010},
keywords = {Aged, Carcinoma, Non-Small-Cell Lung/blood supply, Carcinoma, Non-Small-Cell Lung/diagnostic imaging*, Carcinoma, Non-Small-Cell Lung/pathology, Chi-Square Distribution, Contrast Media, Female, Humans, Iohexol/analogs & derivatives, Lung Neoplasms/blood supply, Lung Neoplasms/diagnostic imaging*, Lung Neoplasms/pathology, Male, Middle Aged, Prospective Studies, Statistics, Nonparametric, Tomography, X-Ray Computed/methods*},
pages = {863-871}
}

@article{benschop_interventions_2010,
	title = {Interventions for women with endometrioma prior to assisted reproductive technology},
	issn = {1469-493X},
	doi = {10.1002/14651858.CD008571.pub2},
	abstract = {BACKGROUND: Endometriomata are cysts of endometriosis in the ovaries. As artificial reproductive technology (ART) cycles involve oocyte pickup from the ovaries, endometriomata may interfere with the outcome of ART.
OBJECTIVES: To determine the effectiveness and safety of surgery, medical treatment, combination therapy or no treatment for improving reproductive outcomes among women with endometriomata, prior to undergoing ART cycles.
SEARCH STRATEGY: The review authors searched: Cochrane Menstrual Disorders and Subfertility Group Specialised Register of trials, CENTRAL (The Cochrane Library), EMBASE, MEDLINE, PubMed, PsycINFO, CINAHL, DARE, trial registers for ongoing and registered trials, citation indexes, conference abstracts on the ISI Web of Knowledge, Clinical Study Results, OpenSIGLE (July 2010) and handsearched Fertility and Sterility (2008 to 2010).
SELECTION CRITERIA: Randomised controlled trials of any medical, surgical or combination therapy or expectant management for endometriomata prior to ART.
DATA COLLECTION AND ANALYSIS: The trials were independently identified and assessed for risk of bias by two authors. The authors of the trials that were potentially eligible for inclusion were contacted for additional information. Outcomes were expressed as Peto odds ratios and mean differences (MD).
MAIN RESULTS: Eleven trials were identified of which seven were excluded and four with 312 participants were included.No trial reported live birth outcomes. One trial compared gonadotropin-releasing hormone (GnRH) agonist with GnRH antagonist. There was no evidence of a difference for clinical pregnancy rate (CPR), however the number of mature oocytes retrieved (NMOR) was greater with GnRH agonists (MD -1.60, 95\% CI -2.44 to -0.76) and the ovarian response was increased (estradiol (E2) levels on day of human chorionic gonadotropin (hCG) injection) (MD -456.30, 95\% CI -896.06 to -16.54).Surgery (aspiration or cystectomy) versus expectant management (EM) showed no evidence of a benefit for clinical pregnancy with either technique. Aspiration was associated with greater NMOR (MD 0.50, 95\% CI 0.02 to 0.98) and increased ovarian response (E2 levels on day of hCG injection) (MD 685.3, 95\% CI 464.50 to 906.10) compared to EM.Cystectomy was associated with a decreased ovarian response to controlled ovarian hyperstimulation (COH) (MD -510.00, 95\% CI -676.62 to -343.38); no evidence of an effect on the NMOR compared to EM. Aspiration versus cystectomy showed no evidence of a difference in CPR or the NMOR.
AUTHORS' CONCLUSIONS: There was no evidence of an effect on reproductive outcomes in any of the four included trials. Further RCTs of management of endometrioma in women undergoing ART are required.},
	language = {eng},
	number = {11},
	journal = {The Cochrane Database of Systematic Reviews},
	author = {Benschop, Laura and Farquhar, Cindy and van der Poel, Nicolien and Heineman, Maas Jan},
	year = {2010},
	pmid = {21069706},
	keywords = {Endometriosis, Female, Gonadotropin-Releasing Hormone, Humans, Infertility, Female, Ovarian Hyperstimulation Syndrome, Pregnancy, Randomized Controlled Trials as Topic, Reproductive Techniques, Assisted, Sperm Injections, Intracytoplasmic},
	pages = {CD008571}
}

Paper  doi  abstract   bibtex   

@article{fellman_one-year_2009,
	title = {One-year survival of extremely preterm infants after active perinatal care in {Sweden}.},
	volume = {301},
	issn = {1538-3598},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19491184},
	doi = {10.1001/jama.2009.771},
	abstract = {CONTEXT: Up-to-date information on infant survival after extremely preterm birth is needed for assessing perinatal care services, clinical guidelines, and parental counseling.

OBJECTIVE: To determine the 1-year survival in all infants born before 27 gestational weeks in Sweden during 2004-2007.

DESIGN, SETTING, AND PATIENTS: Population-based prospective observational study of extremely preterm infants (707 live-born and 304 stillbirths) born to 887 mothers in 904 deliveries (102 multiple births) in all obstetric and neonatal units in Sweden from April 1, 2004, to March 31, 2007.

MAIN OUTCOME MEASURES: Infant survival to 365 days and survival without major neonatal morbidity (intraventricular hemorrhage grade {\textgreater}2, retinopathy of prematurity stage {\textgreater}2, periventricular leukomalacia, necrotizing enterocolitis, severe bronchopulmonary dysplasia). Associations between perinatal interventions and survival.

RESULTS: The incidence of extreme prematurity was 3.3 per 1000 infants. Overall perinatal mortality was 45\% (from 93\% at 22 weeks to 24\% at 26 weeks), with 30\% stillbirths, including 6.5\% intrapartum deaths. Of live-born infants, 91\% were admitted to neonatal intensive care and 70\% survived to 1 year of age (95\% confidence interval [CI], 67\%-73\%). The Kaplan-Meier survival estimates for 22, 23, 24, 25, and 26 weeks were 9.8\% (95\% CI, 4\%-23\%), 53\% (95\% CI, 44\%-63\%), 67\% (95\% CI, 59\%-75\%), 82\% (95\% CI, 76\%-87\%), and 85\% (95\% CI, 81\%-90\%), respectively. Lower risk of infant death was associated with tocolytic treatment (adjusted for gestational age odds ratio [OR], 0.43; 95\% CI, 0.36-0.52), antenatal corticosteroids (OR, 0.44; 95\% CI, 0.24-0.81), surfactant treatment within 2 hours after birth (OR, 0.47; 95\% CI, 0.32-0.71), and birth at a level III hospital (OR, 0.49; 95\% CI, 0.32-0.75). Among 1-year survivors, 45\% had no major neonatal morbidity.

CONCLUSION: During 2004 to 2007, 1-year survival of infants born alive at 22 to 26 weeks of gestation in Sweden was 70\% and ranged from 9.8\% at 22 weeks to 85\% at 26 weeks.},
	number = {21},
	urldate = {2015-05-26},
	journal = {JAMA},
	author = {Fellman, Vineta and Hellström-Westas, Lena and Norman, Mikael and Westgren, Magnus and Källén, Karin and Lagercrantz, Hugo and Marsál, Karel and Serenius, Fredrik and Wennergren, Margareta},
	month = jun,
	year = {2009},
	pmid = {19491184},
	keywords = {Female, Gestational Age, Humans, Infant, Infant Mortality, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Infant, Premature, Diseases: mortality, Intensive Care, Neonatal, Male, Morbidity, Perinatal Care, Perinatal Mortality, Pregnancy, Premature Birth, Prospective Studies, Risk, Survival Analysis, Sweden, Sweden: epidemiology},
	pages = {2225--33},
}

Paper  doi  abstract   bibtex   

@article{wood_hyperactive-impulsive_2009,
	title = {Hyperactive-impulsive symptom scores and oppositional behaviours reflect alternate manifestations of a single liability.},
	volume = {39},
	issn = {1573-3297},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2801319&tool=pmcentrez&rendertype=abstract},
	doi = {10.1007/s10519-009-9290-z},
	abstract = {Attention deficit hyperactivity disorder and oppositional behaviours frequently co-occur, We aimed to study the etiology of this overlap in a general population-based twin sample, assessing the symptom domains of hyperactivity-impulsivity and inattentiveness separately for their overlap with oppositionality. We further aimed to investigate whether rater bias may contribute to the overlap in previous data which used one rater only. Using parent and teacher ratings on hyperactivity-impulsivity, inattentiveness and oppositionality, and actigraph measurements of activity level, for 668 7-9-year-old twin pairs, oppositionality showed a higher overlap with hyperactivity-impulsivity (r = 0.95) than with inattentiveness (r = 0.52) and all etiological influences on hyperactivity-impulsivity were shared with those on oppositionality, indicated by a genetic correlation of 0.95 and a child-specific environmental correlation of 0.94. Actigraph data did not show an overlap with ratings of oppositionality. In middle childhood, symptoms of hyperactivity-impulsivity and oppositional behaviour may represent the same underlying liability, whereas the inattentive domain is more distinct.},
	number = {5},
	urldate = {2012-07-23},
	journal = {Behavior genetics},
	author = {Wood, Alexis C and Rijsdijk, Frühling and Asherson, Philip and Kuntsi, Jonna},
	month = sep,
	year = {2009},
	pmid = {19633943},
	keywords = {Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: dia, Attention Deficit Disorder with Hyperactivity: gen, Attention Deficit and Disruptive Behavior Disorder, Child, Comorbidity, Diagnosis, Differential, Diseases in Twins, Environment, Family Health, Female, Genetic Predisposition to Disease, Humans, Male, Principal Component Analysis, Twins, Dizygotic, Twins, Monozygotic},
	pages = {447--60},
}

Paper  Website  abstract   bibtex   

@article{
 title = {The effect of CO2 acidified sea water and reduced salinity on aspects of the embryonic development of the amphipod Echinogammarus marinus (Leach).},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Amphipoda,Amphipoda: growth & development,Animals,Carbon Dioxide,Carbon Dioxide: chemistry,Female,Hydrogen-Ion Concentration,Salinity,Seawater,Seawater: chemistry},
 pages = {1187-91},
 volume = {58},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19541328},
 month = {8},
 publisher = {Elsevier Ltd},
 id = {0111b01d-a0b1-333f-b64e-06e303ba9515},
 created = {2012-12-06T09:10:32.000Z},
 accessed = {2010-07-14},
 file_attached = {true},
 profile_id = {0b777e31-8c9d-39dd-97a3-3e054bd99cfe},
 group_id = {764582e8-5773-3a66-8d6b-9b40e4fb5a88},
 last_modified = {2017-03-14T17:27:14.020Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Egilsdottir2009b},
 abstract = {We investigated the effect of CO(2) acidified sea water (S=35, 22 and 10(PSU)) on embryonic development of the intertidal amphipod Echinogammarus marinus (Leach). Low pH, but not low salinity (22(PSU)), resulted in a more protracted embryonic development in situ although the effect was only evident at low salinity. However reduced salinity, not pH, exerted a strong significant effect, on numbers and calcium content of hatchlings. Females exposed to low salinity (10(PSU)) did not carry eggs through to hatching. There was no significant difference in the number of viable hatchlings between females cultured in 22 and 35(PSU) but the exoskeleton of the juveniles at 22(PSU) contained significantly less calcium. Ocean acidification may affect aspects of E. marinus development but exposure to realistic low salinities appear, in the short term, to be more important in impacting development than exposure to CO(2) acidified sea water at levels predicted for 300 years time.},
 bibtype = {article},
 author = {Egilsdottir, Hronn and Spicer, John I and Rundle, Simon D},
 journal = {Marine pollution bulletin},
 number = {8}
}

@article{setakis_changes_2008,
	title = {Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib},
	volume = {59},
	issn = {0004-3591},
	doi = {10.1002/art.23925},
	abstract = {OBJECTIVE: To evaluate the impact of rofecoxib withdrawal on the characteristics of patients prescribed selective cyclooxygenase 2 (COX-2) inhibitors.
METHODS: The General Practice Research Database was used to identify patients age {\textgreater} or =18 years who were prescribed a selective COX-2 inhibitor. Various patient characteristics were noted at the start of therapy: age, sex, nonsteroidal antiinflammatory drug-related risk factors for upper gastrointestinal (GI) events, and the Framingham risk score for cardiovascular disease. Logistic regression was used to compare patients using selective COX-2 inhibitors before and after September 2004.
RESULT: The study population included 171,645 patients receiving selective COX-2 inhibitors. The number of users substantially increased over time until September 2004 and sharply declined thereafter. Approximately 80\% stopped selective COX-2 inhibitor therapy within 6 months. Patients receiving selective COX-2 inhibitors after September 2004 were younger and included more men compared with those receiving therapy before September 2004. There was no change before and after September 2004 in the proportion of patients with GI risk factors or high Framingham risk scores, after adjustment for age and sex. A correlation was found between presence of GI risk factors and high Framingham risk scores. Only 20\% of patients receiving selective COX-2 inhibitors had GI risk factors but low Framingham risk score, which did not change after September 2004.
CONCLUSION: There was no channeling in the usage of selective COX-2 inhibitors toward patients with a high risk of GI and low risk of cardiovascular disease following the withdrawal of rofecoxib.},
	language = {eng},
	number = {8},
	journal = {Arthritis and Rheumatism},
	author = {Setakis, E. and Leufkens, H. G. M. and van Staa, T. P.},
	month = aug,
	year = {2008},
	pmid = {18668614},
	keywords = {Adolescent, Adult, Aged, Cardiovascular Diseases, Cyclooxygenase 2 Inhibitors, Databases, Factual, Drug Prescriptions, Drug Utilization Review, Female, Gastrointestinal Diseases, Great Britain, Humans, Lactones, Logistic Models, Male, Middle Aged, Rheumatic Diseases, Risk Factors, Sulfones, incidence},
	pages = {1105--1111}
}

Paper  doi  abstract   bibtex   

@article{Hadjikhani2008a,
	title = {Pointing with the eyes: the role of gaze in communicating danger.},
	volume = {68},
	issn = {1090-2147},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2582139&tool=pmcentrez&rendertype=abstract},
	doi = {10.1016/j.bandc.2008.01.008},
	abstract = {Facial expression and direction of gaze are two important sources of social information, and what message each conveys may ultimately depend on how the respective information interacts in the eye of the perceiver. Direct gaze signals an interaction with the observer but averted gaze amounts to "pointing with the eyes", and in combination with a fearful facial expression may signal the presence of environmental danger. We used fMRI to examine how gaze direction influences brain processing of facial expression of fear. The combination of fearful faces and averted gazes activated areas related to gaze shifting (STS, IPS) and fear-processing (amygdala, hypothalamus, pallidum). Additional modulation of activation was observed in motion detection areas, in premotor areas and in the somatosensory cortex, bilaterally. Our results indicate that the direction of gaze prompts a process whereby the brain combines the meaning of the facial expression with the information provided by gaze direction, and in the process computes the behavioral implications for the observer.},
	number = {1},
	urldate = {2013-08-25},
	journal = {Brain and cognition},
	author = {Hadjikhani, Nouchine and Hoge, Rick and Snyder, Josh and de Gelder, Beatrice},
	month = oct,
	year = {2008},
	pmid = {18586370},
	keywords = {\#nosource, Adult, Amygdala, Amygdala: physiology, Analysis of Variance, Brain, Brain: physiology, Cerebral Cortex, Cerebral Cortex: physiology, Dominance, Cerebral, Dominance, Cerebral: physiology, Facial Expression, Fear, Fear: physiology, Female, Fixation, Ocular, Humans, Hypothalamus, Hypothalamus: physiology, Image Processing, Computer-Assisted, Image Processing, Computer-Assisted: methods, Magnetic Resonance Imaging, Magnetic Resonance Imaging: methods, Male, Pattern Recognition, Visual, Pattern Recognition, Visual: physiology, Photic Stimulation, Photic Stimulation: methods, Social Perception, Somatosensory Cortex, Somatosensory Cortex: physiology, Visual Perception, Visual Perception: physiology, Young Adult, cognitiva, humanos},
	pages = {1--8},
}

Paper  abstract   bibtex   

@article{farrant_takayasus_2008,
	title = {Takayasu's arteritis following {Crohn}'s disease in a young woman: any evidence for a common pathogenesis?},
	volume = {14},
	issn = {1007-9327},
	shorttitle = {Takayasu's arteritis following {Crohn}'s disease in a young woman},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/18609696},
	abstract = {Takayasu's arteritis and Crohn's disease are chronic inflammatory diseases of uncertain aetiology. They rarely occur together, with only twenty nine cases of co-existent Takayasu's arteritis and Crohn's disease reported in the literature. In 88\% of these cases, Takayasu's arteritis was diagnosed simultaneously or following a diagnosis of Crohn's disease. We present a case of a young Caucasian medical student, incidentally found to have bilateral carotid bruits on auscultation by a colleague. Magnetic resonance angiography revealed stenoses of the common carotid arteries with established collaterals, and a diagnosis of Type 1 Takayasu's arteritis was made. An 18(F)-fluorodeoxyglucose positron emission tomography scan revealed no active disease. Nine months later, she presented with a short history of abdominal pain, vomiting and abdominal distension. Barium follow-through and computer tomography revealed a terminal ileal stricture and proximal small bowel dilation. An extended right hemicoloectomy was performed and histopathology supported a diagnosis of Crohn's disease. This case report is presented with a particular focus on the temporal relationship between these two disease processes and explores whether their concurrence is more than just co-incidence.},
	number = {25},
	urldate = {2010-08-27},
	journal = {World Journal of Gastroenterology: WJG},
	author = {Farrant, Melissa- A L and Mason, Justin C and Wong, Newton A C S and Longman, Robert J},
	month = jul,
	year = {2008},
	pmid = {18609696},
	keywords = {Adult, Auscultation, Carotid Artery, Common, Colectomy, Collateral Circulation, Crohn Disease, Female, Humans, Incidental Findings, Magnetic Resonance Angiography, Takayasu Arteritis, Tomography, X-Ray Computed, Ultrasonography, Doppler, Color},
	pages = {4087--4090},
}

@article{boussekey_pilot_2008,
	title = {A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock.},
	volume = {34},
	issn = {0342-4642 0342-4642},
	doi = {10.1007/s00134-008-1127-3},
	abstract = {OBJECTIVE: High volume hemofiltration (HVHF) has shown potential benefits in septic animals and a few reports suggested a hemodynamic improvement in humans. However, randomized studies are still lacking. Our goal was to evaluate the hemodynamic effects of HVHF in septic shock patients with acute renal failure (ARF). DESIGN AND SETTING: Prospective randomized study in an intensive care unit (ICU). PATIENTS: Twenty patients with septic shock and ARF. INTERVENTIONS: Patients were randomized to either high volume hemofiltration [HVHF 65 ml/(kg h)] or low volume hemofiltration [LVHF 35 ml/(kg h). Vasopressor dose was adjusted to reach a mean arterial pressure (MAP) {\textgreater} 65 mmHg. MEASUREMENTS AND RESULTS: We performed six hourly measurements of MAP, norepinephrine dose, PaO(2)/FiO(2) and  lactate, and four daily urine output and logistic organ dysfunction (LOD) score.  Baseline characteristics of the two groups were comparable on randomization. Mean norepinephrine dose decreased more rapidly after 24 h of HVHF treatment compared  to LVHF treatment (P = 0.004) whereas lactate and PaO(2)/FiO(2) did not differ between the two treatment groups. During the 4-day follow-up, urine output was slightly increased in the HVHF group (P = 0.059) but the LOD score evolution was  not different. Duration of mechanical ventilation, renal replacement therapy and  ICU length of stay were also comparable. Survival on day 28 was not affected. CONCLUSION: HVHF decreased vasopressor requirement and tended to increase urine output in septic shock patients with renal failure. However, a larger trial is required to confirm our results and perhaps to show a benefit in survival.},
	language = {eng},
	number = {9},
	journal = {Intensive care medicine},
	author = {Boussekey, Nicolas and Chiche, Arnaud and Faure, Karine and Devos, Patrick and Guery, Benoit and d'Escrivan, Thibaud and Georges, Hugues and Leroy, Olivier},
	month = sep,
	year = {2008},
	pmid = {18542921},
	keywords = {Humans, Adult, Female, Aged, Intensive Care Units, Male, Middle Aged, Aged, 80 and over, *Hospital Mortality, Acute Kidney Injury/*complications/*therapy, APACHE, Blood Pressure/drug effects, Hemofiltration/*methods, Norepinephrine/administration \& dosage/*therapeutic use, Respiration, Artificial, Shock, Septic/classification/*complications/*therapy, Vasoconstrictor Agents/administration \& dosage/*therapeutic use},
	pages = {1646--1653}
}

Paper  doi  abstract   bibtex   

@article{wood_high_2008,
	title = {High heritability for a composite index of children's activity level measures.},
	volume = {38},
	issn = {0001-8244},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2493057&tool=pmcentrez&rendertype=abstract},
	doi = {10.1007/s10519-008-9196-1},
	abstract = {Despite the high heritability of children's activity level, which forms part of the core symptom domain of hyperactivity-impulsivity within attention deficit hyperactivity disorder (ADHD), there has only been a limited success with identifying candidate genes involved in its etiology. This may reflect a lack of understanding about the different measures used to define activity level across studies. We aimed to study the genetic and environmental etiology across three measures of activity level: parent and teacher ratings of hyperactivity-impulsivity and actigraph measurements, within a population-based sample of 463 7-9 year old twin pairs. We further examined ways in which the three measures could be combined for future molecular studies. Phenotypic correlations across measures were modest, but a common underlying phenotypic factor was highly heritable (92\%); as was a simple aggregation of all three measurements (77\%). This suggests that distilling what is common to all three measures may be a good method for generating a quantitative trait suitable for molecular studies of activity level in children. The high heritabilities found are encouraging in this respect.},
	number = {3},
	urldate = {2015-05-12},
	journal = {Behavior genetics},
	author = {Wood, Alexis C and Rijsdijk, Frühling and Saudino, Kimberly J and Asherson, Philip and Kuntsi, Jonna},
	month = may,
	year = {2008},
	pmid = {18297388},
	keywords = {Attention Deficit and Disruptive Behavior Disorder, Child, Family Health, Female, Genetic Predisposition to Disease, Humans, Impulsive Behavior, Impulsive Behavior: genetics, Male, Models, Genetic, Models, Statistical, Motor Activity, Multivariate Analysis, Parents, Phenotype},
	pages = {266--76},
}

@Article{Elliot2007,
  author   = {Andrew J Elliot and Markus A Maier and Arlen C Moller and Ron Friedman and J\"org Meinhardt},
  journal  = {J Exp Psychol Gen},
  title    = {Color and psychological functioning: the effect of red on performance attainment.},
  year     = {2007},
  number   = {1},
  pages    = {154-68},
  volume   = {136},
  abstract = {This research focuses on the relation between color and psychological
	functioning, specifically, that between red and performance attainment.
	Red is hypothesized to impair performance on achievement tasks, because
	red is associated with the danger of failure in achievement contexts
	and evokes avoidance motivation. Four experiments demonstrate that
	the brief perception of red prior to an important test (e.g., an
	IQ test) impairs performance, and this effect appears to take place
	outside of participants' conscious awareness. Two further experiments
	establish the link between red and avoidance motivation as indicated
	by behavioral (i.e., task choice) and psychophysiological (i.e.,
	cortical activation) measures. The findings suggest that care must
	be taken in how red is used in achievement contexts and illustrate
	how color can act as a subtle environmental cue that has important
	influences on behavior.},
  doi      = {10.1037/0096-3445.136.1.154},
  keywords = {Achievement, Adolescent, Adult, Color Perception, Escape Reaction, Female, Humans, Male, Psychology, 17324089},
}

Paper  abstract   bibtex   

@article{bidwell_testing_2007,
	title = {Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder.},
	volume = {62},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2687149&tool=pmcentrez&rendertype=abstract},
	abstract = {BACKGROUND: Neurocognitive deficits associated with attention-deficit/hyperactivity disorder (ADHD) might be useful intermediate endophenotypes for determining specific genetic pathways that contribute to ADHD. METHODS: This study administered 17 measures from prominent neuropsychological theories of ADHD (executive function, processing speed, arousal regulation and, motivation/delay aversion) in dizygotic (DZ) twin pairs discordant for ADHD and control twin pairs (ages 8-18 years) to compare performance between twins affected with ADHD (n = 266), their unaffected co-twins (n = 228), and control children from twin pairs without ADHD or learning difficulties (n = 332). RESULTS: The ADHD subjects show significant impairment on executive function, processing speed, and response variability measures compared with control subjects. Unaffected co-twins of ADHD subjects are significantly impaired on nearly all the same measures as their ADHD siblings, even when subclinical symptoms of ADHD are controlled. CONCLUSIONS: Executive function, processing speed, and response variability deficits might be useful endophenotypes for genetic studies of ADHD.},
	number = {9},
	journal = {Biological Psychiatry},
	author = {Bidwell, L Cinnamon and Willcutt, Erik G and Defries, John C and Pennington, Bruce F},
	year = {2007},
	note = {Publisher: Department of Psychology, University of Colorado, Boulder, Colorado, USA. lcb@colorado.edu},
	keywords = {adolescent, analysis variance, attention deficit disorder with hyperactivity, attention deficit disorder with hyperactivity gen, attention deficit disorder with hyperactivity phy, child, cognition disorders, cognition disorders genetics, cognition disorders physiopathology, diseases twins, diseases twins genetics, diseases twins psychology, female, genetic predisposition disease, genetic predisposition disease genetics, humans, intelligence tests, male, neuropsychological tests, neuropsychological tests statistics \& numerical d, phenotype, problem solving, reading, sex factors, twins},
	pages = {991--998},
}

Website  abstract   bibtex   

@article{
 title = {No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Adult,Apolipoproteins E/*genetics,Cell Adhesion Molecules/*genetics,Disease Progression,Female,Gene Frequency,Genotype,Humans,Male,Middle Aged,Multiple Sclerosis/*genetics/physiopathology,Severity of Illness Index},
 pages = {156-160},
 volume = {186},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17376543},
 edition = {2007/03/23},
 id = {97823616-1f4d-37f6-a788-8ec55f360a74},
 created = {2017-06-19T13:43:25.441Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:25.558Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Ramagopalan, S V<m:linebreak/>Deluca, G C<m:linebreak/>Morrison, K M<m:linebreak/>Herrera, B M<m:linebreak/>Dyment, D A<m:linebreak/>Orton, S<m:linebreak/>Bihoreau, M T<m:linebreak/>Degenhardt, A<m:linebreak/>Pugliatti, M<m:linebreak/>Sadovnick, A D<m:linebreak/>Sotgiu, S<m:linebreak/>Ebers, G C<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>Netherlands<m:linebreak/>Journal of neuroimmunology<m:linebreak/>S0165-5728(07)00061-6<m:linebreak/>J Neuroimmunol. 2007 May;186(1-2):156-60. Epub 2007 Mar 21.</m:note>},
 abstract = {Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. Apolipoprotein E (APOE) is involved in neuronal remodelling and several studies have attempted to examine the effect of APOE on MS disease severity, but its function in modifying the course of MS is controversial. It has been suggested recently that PVRL2, not APOE, is the locus on chromosome 19 which influences clinical outcome of MS. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of APOE and PVRL2 on MS disease severity. The MS cases selected represent the prognostic best 5% (benign MS) and worst 5% (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that APOE or PVRL2 have any outcome modifying activity. We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS.},
 bibtype = {article},
 author = {Ramagopalan, S V and Deluca, G C and Morrison, K M and Herrera, B M and Dyment, D A and Orton, S and Bihoreau, M T and Degenhardt, A and Pugliatti, M and Sadovnick, A D and Sotgiu, S and Ebers, G C},
 journal = {J Neuroimmunol},
 number = {1-2}
}

@article{gentilini_is_2007,
	title = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours? {Lessons} from a series in a single institution},
	volume = {18},
	issn = {0923-7534},
	shorttitle = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours?},
	doi = {10.1093/annonc/mdm182},
	abstract = {BACKGROUND: Current guidelines for post-mastectomy radiotherapy (PMRT) derive largely from extrapolating information from multicentre trials. The aim of this study was to describe outcomes of patients who underwent mastectomy without radiotherapy in a single institution.
PATIENTS AND METHODS: 650 patients had total mastectomy and axillary dissection without PMRT between 1997 and 2001. Median follow-up was 65 months.
RESULTS: 5-year cumulative incidence of loco-regional recurrence (LRR) was 6.8\% (3.0, 8.1, 9.9\% in node negative, 1-3, {\textgreater} or =4 positive nodes, respectively). At the multivariate analysis, positive lymph nodes and endocrine non-responsive tumours were found to shorten LRR disease-free survival. In patients with positive hormone receptors, 5-year cumulative incidence of LRR disease-free survival were 2.3\%, 7.6\% and 7.6\% for node negative, 1-3 and {\textgreater} or =4 positive lymph nodes, respectively. The same figures were 5.9\%, 10.3\% and 20.0\% in patients with endocrine non-responsive tumours.
CONCLUSIONS: patients with endocrine-responsive tumours treated by mastectomy and complete (level III) axillary dissection have a low risk of LRR even if four or more positive lymph nodes are involved, thus giving rise to doubts on the use of PMRT in this subset of patients. On the other hand, PMRT might play a role for patients with negative hormone receptors and four or more positive nodes.},
	language = {eng},
	number = {8},
	journal = {Annals of oncology: official journal of the European Society for Medical Oncology / ESMO},
	author = {Gentilini, O and Botteri, E and Rotmensz, N and Intra, M and Gatti, G and Silva, L and Peradze, N and Sahium, R C and Gil, L B and Luini, A and Veronesi, P and Galimberti, V and Gandini, S and Goldhirsh, A and Veronesi, U},
	month = aug,
	year = {2007},
	pmid = {17693648},
	keywords = {Adult, Axilla, Breast Neoplasms, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Lymph Node Excision, mastectomy, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, Adjuvant, Retrospective Studies, Treatment Outcome},
	pages = {1342--1347},
	file = {Ann Oncol-2007-Gentilini-1342-7.pdf:files/46589/Ann Oncol-2007-Gentilini-1342-7.pdf:application/pdf}
}

Paper  doi  bibtex   

@article{ gostin_mandatory_2007,
  title = {Mandatory {HPV} vaccination: public health vs private wealth},
  volume = {297},
  issn = {1538-3598},
  shorttitle = {Mandatory {HPV} vaccination},
  url = {http://www.progressiveconvergence.com/JAMA%20article.pdf},
  doi = {10.1001/jama.297.17.1921},
  language = {eng},
  number = {17},
  journal = {{JAMA}: the journal of the American Medical Association},
  author = {Gostin, Lawrence O and DeAngelis, Catherine D},
  month = {May},
  year = {2007},
  pmid = {17473303},
  keywords = {Female, Health Policy, Humans, Papillomavirus Vaccines, Policy Making, United States, Uterine Cervical Neoplasms, Vaccination},
  pages = {1921--1923}
}

@Article{Kovacs_2006_9144,
  author = {Kovacs, L. and Yassouridis, A. and Zimmermann, A. and Brockmann, G. and Wohnl, A. and Blaschke, M. and Eder, M. and Schwenzer-Zimmerer, K. and Rosenberg, R. and Papadopulos, N. A. and Biemer, E.},
 journal = {Annals of Plastic Surgery},
 number = {3},
 pages = {229-236},
 title = {Optimization of 3-dimensional imaging of the breast region with 3-dimensional laser scanners},
 volume = {56},
 year = {2006},
 keywords = {Breast/*anatomy, &, histology, Female, Humans, *Image, Processing, Computer-Assisted, Imaging, Three-Dimensional/*instrumentation, Lasers/diagnostic, use, Manikins, Phantoms, Imaging, Sensitivity, and, Specificity},
 title_with_no_special_chars = {Optimization of 3dimensional imaging of the breast region with 3dimensional laser scanners}
}

@article{fox_prevalence_2006,
	title = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database: {A} series of retrospective analyses of data from 1998 through 2002},
	volume = {28},
	issn = {0149-2918},
	shorttitle = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database},
	doi = {10.1016/j.clinthera.2006.03.005},
	abstract = {BACKGROUND: Since the mid-1990s, the development of new oral antidiabetic agents (OAs) and treatment guidelines have created an opportunity to improve glycemic control in patients with type 2 diabetes.
OBJECTIVES: This study aimed to assess the prevalence of good and inadequate glycemic control across a 5-year period among patients with diabetes in the United Kingdom. It also investigated the factors associated with achieving glycemic targets.
METHODS: This was a retrospective, cross-sectional analysis of data from the General Practice Research Database. Three limits were used to assess glycosylated hemoglobin (HbA1c): 6.5\%, 7.0\%, or 7.5\%. Values above the cutoffs indicated inadequate control of HbA1c; those at or below the cutoffs indicated good control. The study evaluated clinical and pharmacy data from the years 1998 to 2002 for patients with type 2 diabetes, {\textgreater} or =2 years of follow-up, and {\textgreater} or =2 HbA1c measurements during the first year. Five independent cross-sectional analyses were conducted, grouping data by year. Statistical significance was determined by Student t and chi2 tests.
RESULTS: Data were analyzed for 10,663 patients aged 17 to 98 years. The number of total eligible type 2 diabetes patients increased over the course of the study period: 5674 patients in 1998, 6553 in 1999, 7314 in 2000, 7323 in 2001, and 6192 in 2002. Overall, the study population had a mean (SD) age of 66 (11.0) years, was 53\% male (3033/5674), and had a body mass index of 29 kg/m(2). Seventy-six percent of patients had HbA1c {\textgreater}7.0\% and 37\% were taking {\textgreater} or =2 oral agents. In 1998 and 2002, 79\% (4482/5674) and 76\% (4732/6192) of patients, respectively, had inadequate glycemic control, defined as HbA1c {\textgreater}7.0\%. When defined as HbA1c {\textgreater}7.5\%, 69\% (3923/5674) and 62\% (3814/6192) of patients, respectively, had inadequate control. Finally, when defined as HbA1c {\textgreater}6.5\%, 88\% (5011/5674) of patients in both 1998 and 2002 had inadequate control. Compared with patients with good disease control (HbA1c {\textless} or =7.0\%), patients with inadequate control were approximately 2 years younger (P {\textless} 0.001) and had been prescribed more OAs: 41\% received {\textgreater} or =2 OAs in 1998 and 52\% in 2002, compared with 23\% and 34\% (both, P = 0.001), respectively, of patients with good glycemic control (P {\textless} 0.02). Sex, number of diabetes complications, and number of comorbidities did not differ between groups (P = NS).
CONCLUSIONS: Despite the introduction of new OAs and treatment guidelines, the prevalence of inadequate glycemic control remains high ({\textgreater}60\%) in patients with type 2 diabetes in the United Kingdom. Regardless of the HbA1c cutoff, patients with inadequate control were younger and received prescriptions for more OAs than patients with good control.},
	language = {eng},
	number = {3},
	journal = {Clinical Therapeutics},
	author = {Fox, Kathleen M. and Gerber Pharmd, Robert A. and Bolinder, Bjorn and Chen, Jack and Kumar, Sanjaya},
	month = mar,
	year = {2006},
	pmid = {16750453},
	keywords = {Administration, Oral, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Family Practice, Female, Great Britain, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Retrospective Studies, databases as topic},
	pages = {388--395}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Maternal transfer of organohalogen contaminants and metabolites to eggs of Arctic-breeding glaucous gulls.},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Animals,Arctic Regions,Biological Transport,Charadriiformes,Charadriiformes: metabolism,Eggs,Eggs: analysis,Environmental Monitoring,Environmental Monitoring: methods,Environmental Pollutants,Environmental Pollutants: analysis,Environmental Pollutants: blood,Environmental Pollutants: metabolism,Female,Gas Chromatography-Mass Spectrometry,Mothers,Norway,Pesticide Residues,Pesticide Residues: analysis,Pesticide Residues: blood,Pesticide Residues: metabolism,Polychlorinated Biphenyls,Polychlorinated Biphenyls: analysis,Polychlorinated Biphenyls: blood,Polychlorinated Biphenyls: metabolism},
 pages = {1053-60},
 volume = {144},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16563578},
 month = {12},
 id = {740e5ba5-c77d-366e-a109-7383cb39d7ff},
 created = {2012-10-26T12:49:03.000Z},
 accessed = {2012-10-26},
 file_attached = {true},
 profile_id = {c6c6f844-18d2-32db-a619-2e915134a952},
 group_id = {764582e8-5773-3a66-8d6b-9b40e4fb5a88},
 last_modified = {2017-03-14T17:27:14.020Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Verreault2006},
 abstract = {Eggs of seabirds have routinely been used as indicators of environmental pollution in the Arctic. However, the variability in organohalogen concentration and composition associated with the laying sequence, have not been defined. We examined a suite of PCBs, organochlorine (OC) pesticides and by-products, polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs) and methylsulfonyl- (MeSO2) PCBs in complete 3-egg clutches of glaucous gulls (Larus hyperboreus), and plasma samples of the laying females collected from the Norwegian Arctic. SigmaPCB, SigmaOC and SigmaPBDE, but not SigmaMeSO2-PCB, concentrations in eggs were positively associated, with increasing magnitude and significance from the first through the last-laid egg, with concentrations in female plasma. However, the concentrations of these organohalogen classes fluctuated irrespective of the laying order in the clutch. In general, maternal transfer favored low K(ow) and/or less persistent compounds, whereas the recalcitrant and/or higher-halogenated compounds were less readily transferred, and consequently more selectively retained in the mother.},
 bibtype = {article},
 author = {Verreault, Jonathan and Villa, Rosa a and Gabrielsen, Geir W and Skaare, Janneche U and Letcher, Robert J},
 journal = {Environmental pollution (Barking, Essex : 1987)},
 number = {3}
}

@article{shepherd_comparison_2006,
	title = {Comparison of {BMD} precision for {Prodigy} and {Delphi} spine and femur scans},
	volume = {17},
	issn = {0937-941X},
	doi = {10.1007/s00198-006-0127-9},
	abstract = {INTRODUCTION: Precision error in bone mineral density (BMD) measurement can be affected by patient positioning, variations in scan analysis, automation of software, and both short- and long-term fluctuations of the densitometry equipment. Minimization and characterization of these errors is essential for reliable assessment of BMD change over time.
METHODS: We compared the short-term precision error of two dual-energy X-ray absorptiometry (DXA) devices: the Lunar Prodigy (GE Healthcare) and the Delphi (Hologic). Both are fan-beam DXA devices predominantly used to measure BMD of the spine and proximal femur. In this study, 87 women (mean age 61.6+/-8.9 years) were measured in duplicate, with repositioning, on both systems, at one of three clinical centers. The technologists were International Society for Clinical Densitometry (ISCD) certified and followed manufacturer-recommended procedures. All scans were acquired using 30-s scan modes. Precision error was calculated as the root-mean-square standard deviation (RMS-SD) and coefficient of variation (RMS-\%CV) for the repeated measurements. Right and left femora were evaluated individually and as a combined dual femur precision. Precision error of Prodigy and Delphi measurements at each measurement region was compared using an F test to determine significance of any observed differences.
RESULTS: While precision errors for both systems were low, Prodigy precision errors were significantly lower than Delphi at L1-L4 spine (1.0\% vs 1.2\%), total femur (0.9\% vs 1.3\%), femoral neck (1.5\% vs 1.9\%), and dual total femur (0.6\% vs 0.9\%). Dual femur modes decreased precision errors by approximately 25\% compared with single femur results.
CONCLUSIONS: This study suggests that short-term BMD precision errors are skeletal-site and manufacturer specific. In clinical practice, precision should be considered when determining: (a) the minimum time interval between baseline and follow-up scans and (b) whether a statistically significant change in the patient's BMD has occurred.},
	language = {eng},
	number = {9},
	journal = {Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA},
	author = {Shepherd, J. A. and Fan, B. and Lu, Y. and Lewiecki, E. M. and Miller, P. and Genant, H. K.},
	year = {2006},
	pmid = {16823544},
	keywords = {Absorptiometry, Photon, Aged, Aged, 80 and over, Bone Density, Female, Femur, Femur Neck, Hip Joint, Humans, Lumbar Vertebrae, Middle Aged, Osteoporosis, Postmenopausal, Postmenopause, Reproducibility of Results},
	pages = {1303--1308}
}

@article{westhoff_tacrolimus_2006,
	title = {Tacrolimus in steroid-resistant and steroid-dependent nephrotic syndrome.},
	volume = {65},
	issn = {0301-0430 0301-0430},
	abstract = {BACKGROUND: Steroid resistance and steroid dependence constitute a major problem  in the treatment of minimal-change disease and focal segmental glomerulosclerosis (FSGS). Cyclophosphamide and cyclosporine are well-established alternative immunomodulating agents, whereas data on FK 506 (tacrolimus) are rare. METHODS: The present work provides data from 10 patients of an open, monocentric, non-randomized, prospective trial. Five patients with steroid-dependent minimal-change nephrotic syndrome, 1 patient with steroid-refractory minimal-change disease and 4 patients with steroid-refractory FSGS were started on tacrolimus at trough levels of 5 10 microg/l. In case of steroid-dependence, prednisolone was tapered off in presence oftacrolimus within one month. RESULTS:  Within 6 months, complete remission was achieved in 5 patients (50\%) and partial  remission in 4 patients (40\%), yielding a final response rate of 90\%. One patient was primarily resistent to tacrolimus (steroid-refractory minimal-change), another patient became secondarily resistant to tacrolimus after an initial remission (steroid-refractory FSGS). Average proteinuria significantly decreased  by 77\% from 9.5 +/- 1.4 - 2.2 +/- 1.1 g/day (p {\textless} 0.01). Serum protein significantly raised from 55.0 +/- 1.9 - 64.6 +/- 1.9 g/l (p {\textless} 0.01). Tacrolimus  induced non-significant increases of blood glucose (4.9 +/- 0.1 - 5.1 +/- 0.2 mmol/l), systolic blood pressure (131.4 +/- 7.1 - 139.0 +/- 7.6 mmHg) and creatinine (93.2 +/- 13.9 103.2 +/- 15.3 mmol/l). Five patients have been tapered off tacrolimus so far, nephrotic syndrome relapsed in 4 of them (80\%). Relapse occurred at tacrolimus levels between 2.6 and 6.9 ng/ml. CONCLUSIONS: Our data suggest that tacrolimus may be a promising alternative to cyclosporine both in steroid-resistant and steroid-dependent nephrotic syndrome.},
	language = {eng},
	number = {6},
	journal = {Clinical nephrology},
	author = {Westhoff, T. H. and Schmidt, S. and Zidek, W. and Beige, J. and van der Giet, M.},
	month = jun,
	year = {2006},
	pmid = {16792133},
	keywords = {Adult, Blood Glucose/analysis, Blood Pressure/drug effects, Blood Proteins/analysis, Creatinine/urine, Drug Resistance, Drug Therapy, Combination, Female, Glomerulosclerosis, Focal Segmental/drug therapy, Humans, Male, Middle Aged, Nephrosis, Lipoid/drug therapy, Nephrotic Syndrome/*drug therapy, Prednisolone/therapeutic use, Proteinuria/drug therapy, Steroids/pharmacology/*therapeutic use, Tacrolimus/*therapeutic use},
	pages = {393--400}
}

@article{kuhl_infants_2006,
	title = {Infants show a facilitation effect for native language phonetic perception between 6 and 12 months},
	volume = {9},
	issn = {1363-755X},
	doi = {10.1111/j.1467-7687.2006.00468.x},
	abstract = {Patterns of developmental change in phonetic perception are critical to theory development. Many previous studies document a decline in nonnative phonetic perception between 6 and 12 months of age. However, much less experimental attention has been paid to developmental change in native-language phonetic perception over the same time period. We hypothesized that language experience in the first year facilitates native-language phonetic performance between 6 and 12 months of age. We tested 6-8- and 10-12-month-old infants in the United States and Japan to examine native and nonnative patterns of developmental change using the American English /r-l/ contrast. The goals of the experiment were to: (a) determine whether facilitation characterizes native-language phonetic change between 6 and 12 months of age, (b) examine the decline previously observed for nonnative contrasts and (c) test directional asymmetries for consonants. The results show a significant increase in performance for the native-language contrast in the first year, a decline in nonnative perception over the same time period, and indicate directional asymmetries that are constant across age and culture. We argue that neural commitment to native-language phonetic properties explains the pattern of developmental change in the first year.},
	language = {eng},
	number = {2},
	journal = {Developmental Science},
	author = {Kuhl, Patricia K. and Stevens, Erica and Hayashi, Akiko and Deguchi, Toshisada and Kiritani, Shigeru and Iverson, Paul},
	month = mar,
	year = {2006},
	pmid = {16472309},
	keywords = {Age Factors, Cultural Characteristics, Female, Humans, Infant, Japan, Language Development, Male, Phonetics, Speech Perception, United States},
	pages = {F13--F21},
}

@article{werbrouck_no_2006,
	title = {No difference in cycle pregnancy rate and in cumulative live-birth rate between women with surgically treated minimal to mild endometriosis and women with unexplained infertility after controlled ovarian hyperstimulation and intrauterine insemination},
	volume = {86},
	issn = {1556-5653},
	doi = {10.1016/j.fertnstert.2006.01.044},
	abstract = {OBJECTIVE: The association between infertility and minimal to mild endometriosis is controversial and poorly understood. The clinical pregnancy rate (PR) per cycle after controlled ovarian hyperstimulation (COH) with or without intrauterine insemination (IUI) is reportedly lower in women with surgically untreated minimal to mild endometriosis than in women with unexplained infertility. It is possible that prior laparoscopic removal of endometriosis has a positive effect on the clinical PR after COH and IUI. Therefore, we tested the hypothesis that after COH and IUI the PR per cycle and the cumulative live-birth rate (CLBR) are equal or higher in women with recently surgically treated minimal to mild endometriosis when compared with women with unexplained infertility.
DESIGN: A retrospective, controlled cohort study.
SETTING: Leuven University Fertility Centre, a tertiary academic referral center.
PATIENT(S): One hundred seven women treated during 259 cycles with COH and IUI including patients with endometriosis (n = 58, 137 cycles) and unexplained infertility (n = 49, 122 cycles). All patients with endometriosis had minimal (n = 41, 100 cycles) or mild (n = 17, 37 cycles) disease that had been laparoscopically removed within 7 months before the onset of treatment with COH and IUI.
INTERVENTION(S): Controlled ovarian hyperstimulation using clomiphene citrate (23 cycles) or gonadotrophins (236 cycles) in combination with IUI.
MAIN OUTCOME MEASURE(S): Clinical PR per cycle and CLBR within four cycles of treatment with COH and IUI.
RESULT(S): The clinical PR per cycle was comparable in women with minimal or mild endometriosis (21\% or 18.9\%, respectively) and in women with unexplained infertility (20.5\%). The CLBR within four cycles of COH and IUI was also comparable in women with minimal endometriosis, mild endometriosis, and unexplained infertility (70.2\%, 68.2 \%, 66.5\%, respectively).
CONCLUSION(S): The data from our study suggest that COH and IUI shortly after laparoscopic excision of endometriosis is as effective as COH and IUI in patients with unexplained subfertility.},
	language = {eng},
	number = {3},
	journal = {Fertility and Sterility},
	author = {Werbrouck, Erika and Spiessens, Carl and Meuleman, Christel and D'Hooghe, Thomas},
	month = sep,
	year = {2006},
	pmid = {16952506},
	keywords = {Adult, Comorbidity, Endometriosis, Female, Humans, Infertility, Insemination, Artificial, Laparoscopy, Live Birth, Menstrual Cycle, Ovulation Induction, Pregnancy, Pregnancy Rate, Prevalence, Prognosis, Retrospective Studies, Treatment Outcome},
	pages = {566--571}
}

@Article{Rasouli_2006_906,
  author = {Rasouli, M.L. and Shavelle, D.M. and French, W.J. and McKay, C.R. and Budoff, M.J.},
 journal = {Coronary Artery Dispatch},
 note = {0954-6928 (Print) Clinical Trial Comparative Study Journal Article Research Support, Non-U.S. Gov't},
 number = {4},
 pages = {359-364},
 title = {Assessment of coronary plaque morphology by contrast-enhanced computed tomographic angiography: {C}omparison with intravascular ultrasound},
 volume = {17},
 year = {2006},
 keywords = {Contrast, Media, Coronary, Angiography/*methods, Coronary, Arteriosclerosis/*radiography/*ultrasonography, Coronary, Vessels/pathology/ultrasonography, Female, Humans, Image, Processing, Computer-Assisted, Male, Middle, Aged, Tomography, X-Ray, Computed/*methods, Ultrasonography, Interventional/*methods},
 title_with_no_special_chars = {Assessment of coronary plaque morphology by contrastenhanced computed tomographic angiography Comparison with intravascular ultrasound}
}

@article{frank_effects_2005,
	title = {Effects of compulsory treatment orders on time to hospital readmission},
	volume = {56},
	issn = {1075-2730},
	doi = {10.1176/appi.ps.56.7.867},
	abstract = {To evaluate the effect of compulsory community treatment orders on subsequent time out of the hospital, the authors studied the admission dates of psychotic patients who had repeated hospitalizations in Quebec, Canada, and divided each admission according to its time in relation to the index admission, during which the judicial order was obtained. The data were stratified by type of admission (early, preindex, index, or postindex), and the hypothesis tested was that the median time to readmission would be greatest for the index admission. The hypothesis was confirmed, supporting previous findings that judicial orders that mandate severely ill psychotic patients to undergo compulsory community treatment are associated with decreased time spent in the hospital and thus increased personal freedom.},
	language = {eng},
	number = {7},
	journal = {Psychiatric Services (Washington, D.C.)},
	author = {Frank, Daniel and Perry, J. Christopher and Kean, Dana and Sigman, Maxine and Geagea, Khalil},
	month = jul,
	year = {2005},
	pmid = {16020822},
	keywords = {Adult, Aged, Aged, 80 and over, Commitment of Mentally Ill, Community Mental Health Services, Female, Follow-Up Studies, Hospitalization, Humans, Male, Mental Disorders, Middle Aged, Patient Admission, Quebec, Time Factors, Treatment Outcome},
	pages = {867--869},
}

Paper  doi  abstract   bibtex   

@article{mazard_neural_2005,
	title = {Neural impact of the semantic content of visual mental images and visual percepts},
	volume = {24},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16099355},
	doi = {10/cwgtzc},
	abstract = {The existence of hemispheric lateralization of visual mental imagery remains controversial. In light of the literature, we used fMRI to test whether processing of mental images of object drawings preferentially engages the left hemisphere to compared non-object drawings. An equivalent comparison was also made while participants actually perceived object and non-object drawings. Although these two conditions engaged both hemispheres, activation was significantly stronger in the left occipito-temporo-frontal network during mental inspection of object than of non-object drawings. This network was also activated when perception of object drawings was compared to that of non-object drawings. An interaction was nonetheless observed: this effect was stronger during imagery than during perception in the left inferior frontal and the left inferior temporal gyrus. Although the tasks subjects performed did not explicitly require semantic analysis, activation of this network probably reflected, at least in part, a semantic and possibly a verbal retrieval component when object drawings were processed. Mental imagery tasks elicited activation of early visual cortex at a lower level than perception tasks. In the context of the imagery debate, these findings indicate that, as previously suggested, figurative imagery could involve primary visual cortex and adjacent areas.},
	number = {3},
	journal = {Brain Res Cogn Brain Res},
	author = {Mazard, A. and Laou, L. and Joliot, M. and Mellet, E.},
	year = {2005},
	keywords = {\#nosource, Adolescent, Adult, Cerebral Cortex/*physiology, Data Interpretation, Statistical, Female, Functional Laterality/physiology, Humans, Image Processing, Computer-Assisted, Imagination/*physiology, Learning/physiology, Magnetic Resonance Imaging, Male, Memory/*physiology, Nerve Net/physiology, Photic Stimulation, Semantics, Visual Cortex/physiology, Visual Perception/*physiology},
	pages = {423--35},
}

@article{reinholz_differential_2005,
	title = {Differential activation of object-selective visual areas by passive viewing of pictures and words.},
	volume = {24},
	doi = {10.1016/j.cogbrainres.2005.04.009},
	abstract = {Functional imaging has shown that pictures of faces (N. Kanwisher, J. McDermott, M.M. Chun, The fusiform face area: a module in human extrastriate cortex specialized for face perception, J. Neurosci. 17 (1997) 4302-4311) and buildings (R. Epstein, N. Kanwisher, A cortical representation of the local visual environment, Nature 391 (1998) 598-601) activate different regions within the lateral occipital complex (LOC). To investigate effects of stimulus format on activation in these areas, we used event-related fMRI to measure brain activity during the passive viewing of pictures showing buildings and faces, and of words identifying these pictures. Consistent with earlier findings, pictures of faces activated bilateral regions in the lateral fusiform gyri, whereas pictures of buildings activated bilateral regions in the parahippocampal gyri. Analyzing the activation elicited by visually presenting the written names of the pictures, however, we did not find an effect of word meaning on the fMRI signal change in these areas: fMRI signal changes for the names of faces and the names of buildings did not differ in any of the areas selectively activated by the corresponding pictures. In general, both word conditions and non-preferred picture conditions elicited similar signal amplitudes. While presentation of words did not lead to strong activation in object-specific areas, activation for words of both categories was found in the left occipito-temporal cortex, close to the location which has tentatively been called 'visual word form area' (L. Cohen, S. Dehaene, L. Naccache, S. Lehéricy, G. Dehaene-Lambertz, et al., The visual word form are: spatial and temporal characterization of an initial stage of reading in normal subjects and posterior split-brain patients, Brain 123 (2000) 291-307), revealing that words were processed effectively during the experiment. Taken together, these results show that names of pictures do not automatically activate the corresponding object-selective areas.},
	language = {eng},
	number = {3},
	journal = {Brain Res Cogn Brain Res},
	author = {Reinholz, Julia and Pollmann, Stefan},
	year = {2005},
	pmid = {15921900},
	note = {Place: Netherlands
ISBN: 0926-6410},
	keywords = {Adult, Brain Mapping, Cerebrovascular Circulation, Face, Female, Form Perception, Functional Laterality, Hemodynamics, Humans, Magnetic Resonance Imaging, Male, Occipital Lobe, Oxygen, Photic Stimulation, Reading, Sex Characteristics, Temporal Lobe, Visual Perception, clinical trial, research support, non-u.s. gov't},
	pages = {702--714},
}

@Article{Szenkovits2005,
  author   = {Gayaneh Szenkovits and Franck Ramus},
  journal  = {Dyslexia},
  title    = {Exploring dyslexics' phonological deficit {I}: lexical vs sub-lexical and input vs output processes.},
  year     = {2005},
  number   = {4},
  pages    = {253-68},
  volume   = {11},
  abstract = {We report a series of experiments designed to explore the locus of
	the phonological deficit in dyslexia. Phonological processing of
	dyslexic adults is compared to that of age- and IQ-matched controls.
	Dyslexics' impaired performance on tasks involving nonwords suggests
	that sub-lexical phonological representations are deficient. Contrasting
	nonword repetition vs auditory nonword discrimination suggests that
	dyslexics are specifically impaired in input phonological processing.
	These data are compatible with the hypothesis that the deficit initially
	affects input sub-lexical processes, and further spreads to output
	and lexical processes in the course of language acquisition. Further
	longitudinal research is required to confirm this scenario as well
	as to tease apart the role of the quality of phonological representations
	from that of verbal short-term memory processes.},
  keywords = {Adult, Dyslexia, Female, Humans, Male, Memory, Phonetics, Vocabulary, 16355747},
}

Paper  doi  bibtex   

@article{vuilleumier_cognitive_2005,
	title = {Cognitive science: staring fear in the face},
	volume = {433},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15635392},
	doi = {10/cj5nks},
	number = {7021},
	journal = {Nature},
	author = {Vuilleumier, P.},
	year = {2005},
	keywords = {\#nosource, *Facial Expression, Adult, Amygdala/*injuries/*physiopathology, Cues, Discrimination Learning/*physiology, Emotions/physiology, Eye, Face/physiology, Fear/*physiology, Female, Fixation, Ocular/physiology, Humans, Male, Photic Stimulation},
	pages = {22--3},
}

Paper  doi  abstract   bibtex   

@article{kitamura_comparative_2005,
	title = {Comparative study of the endocrine-disrupting activity of bisphenol {A} and 19 related compounds.},
	volume = {84},
	issn = {1096-6080},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15635150},
	doi = {10.1093/toxsci/kfi074},
	abstract = {The endocrine-disrupting activities of bisphenol A (BPA) and 19 related compounds were comparatively examined by means of different in vitro and in vivo reporter assays. BPA and some related compounds exhibited estrogenic activity in human breast cancer cell line MCF-7, but there were remarkable differences in activity. Tetrachlorobisphenol A (TCBPA) showed the highest activity, followed by bisphenol B, BPA, and tetramethylbisphenol A (TMBPA); 2,2-bis(4-hydroxyphenyl)-1-propanol, 1,1-bis(4-hydroxyphenyl)propionic acid and 2,2-diphenylpropane showed little or no activity. Anti-estrogenic activity against 17beta-estradiol was observed with TMBPA and tetrabromobisphenol A (TBBPA). TCBPA, TBBPA, and BPA gave positive responses in the in vivo uterotrophic assay using ovariectomized mice. In contrast, BPA and some related compounds showed significant inhibitory effects on the androgenic activity of 5alpha-dihydrotestosterone in mouse fibroblast cell line NIH3T3. TMBPA showed the highest antagonistic activity, followed by bisphenol AF, bisphenol AD, bisphenol B, and BPA. However, TBBPA, TCBPA, and 2,2-diphenylpropane were inactive. TBBPA, TCBPA, TMBPA, and 3,3'-dimethylbisphenol A exhibited significant thyroid hormonal activity towards rat pituitary cell line GH3, which releases growth hormone in a thyroid hormone-dependent manner. However, BPA and other derivatives did not show such activity. The results suggest that the 4-hydroxyl group of the A-phenyl ring and the B-phenyl ring of BPA derivatives are required for these hormonal activities, and substituents at the 3,5-positions of the phenyl rings and the bridging alkyl moiety markedly influence the activities.},
	number = {2},
	journal = {Toxicological sciences},
	author = {Kitamura, Shigeyuki and Suzuki, Tomoharu and Sanoh, Seigo and Kohta, Ryuki and Jinno, Norimasa and Sugihara, Kazumi and Yoshihara, Shin'ichi and Fujimoto, Nariaki and Watanabe, Hiromitsu and Ohta, Shigeru},
	month = apr,
	year = {2005},
	pmid = {15635150},
	keywords = {Air Pollutants, Animals, Breast Neoplasms, Breast Neoplasms: drug therapy, Breast Neoplasms: metabolism, Dose-Response Relationship, Drug, Estrogens, Female, Flame retardants, Growth Hormone, Growth Hormone: metabolism, Hormone Antagonists, Hormone Antagonists: chemistry, Hormone Antagonists: classification, Hormone Antagonists: toxicity, Humans, Mice, NIH 3T3 Cells, NIH 3T3 Cells: drug effects, NIH 3T3 Cells: metabolism, Non-Steroidal, Non-Steroidal: chemistry, Non-Steroidal: classification, Non-Steroidal: toxicity, Occupational, Occupational: toxicity, Phenols, Phenols: chemistry, Phenols: classification, Phenols: toxicity, Pituitary Gland, Pituitary Gland: drug effects, Pituitary Gland: metabolism, Structure-Activity Relationship, Tumor, cell line, frelec, tox},
	pages = {249--59},
}

Paper  abstract   bibtex   

@article{
 title = {Modelling the recent common ancestry of all living humans},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {*Computer Simulation,*Pedigree,*Phylogeny,Emigration and Immigration,Female,Geography,Humans,Male,Monte Carlo Method,Population Density,Population Dynamics,Reproduction,Research Support, U.S. Gov't, P.H.S.,Time Factors},
 pages = {562-566},
 volume = {431},
 id = {c213cb6e-eeef-3a9b-8149-72c0b09cf516},
 created = {2017-06-19T13:43:49.961Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:50.083Z},
 tags = {04/12/23},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>Journal Article</m:note>},
 abstract = {If a common ancestor of all living humans is defined as an individual who is a genealogical ancestor of all present-day people, the most recent common ancestor (MRCA) for a randomly mating population would have lived in the very recent past. However, the random mating model ignores essential aspects of population substructure, such as the tendency of individuals to choose mates from the same social group, and the relative isolation of geographically separated groups. Here we show that recent common ancestors also emerge from two models incorporating substantial population substructure. One model, designed for simplicity and theoretical insight, yields explicit mathematical results through a probabilistic analysis. A more elaborate second model, designed to capture historical population dynamics in a more realistic way, is analysed computationally through Monte Carlo simulations. These analyses suggest that the genealogies of all living humans overlap in remarkable ways in the recent past. In particular, the MRCA of all present-day humans lived just a few thousand years ago in these models. Moreover, among all individuals living more than just a few thousand years earlier than the MRCA, each present-day human has exactly the same set of genealogical ancestors.},
 bibtype = {article},
 author = {Rohde, D L and Olson, S and Chang, J T},
 journal = {Nature},
 number = {7008}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Founder mutations among the Dutch},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {*Founder Effect,Alleles,European Continental Ancestry Group/*genetics/hist,Female,Gene Frequency/genetics,Genetic Diseases, Inborn/*genetics,Genetics, Population,History, 15th Century,History, 16th Century,History, 17th Century,History, 18th Century,History, 19th Century,History, 20th Century,History, 21st Century,History, Ancient,History, Medieval,Humans,Male,Mutation/*genetics,Netherlands,Pedigree},
 pages = {591-600},
 volume = {12},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15010701},
 id = {861dba44-a72a-37ad-a54b-b4f70aed149d},
 created = {2017-06-19T13:46:04.892Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:46:05.028Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1018-4813 (Print)<m:linebreak/>Historical Article<m:linebreak/>Journal Article<m:linebreak/>Review</m:note>},
 abstract = {Many genetic disorders demonstrate mutations that can be traced to a founder, sometimes a person who can be identified. These founder mutations have generated considerable interest, because they facilitate studies of prevalence and penetrance and can be used to quantify the degree of homogeneity within a population. This paper reports on founder mutations among the Dutch and relates their occurrence to the history and demography of the Netherlands. International migration, regional and religious endogamy, and rapid population growth played key roles in shaping the Dutch population. In the first millenniums BC and AD, the Netherlands were invaded by Celts, Romans, Huns, and Germans. In more recent times, large numbers of Huguenots and Germans migrated into the Netherlands. Population growth within the Netherlands was slow until the 19th century, when a period of rapid population growth started. Today, the Dutch population numbers 16 million inhabitants. Several different classes of founder mutations have been identified among the Dutch. Some mutations occur among people who represent genetic isolates within this country. These include mutations for benign familial cholestasis, diabetes mellitus, type I, infantile neuronal ceroid lipofuscinosis, L-DOPA responsive dystonia, and triphalangeal thumb. Although not related to a specific isolate, other founder mutations were identified only within the Netherlands, including those predisposing for hereditary breast-ovarian cancer, familial hypercholesterolemia, frontotemporal dementia, hereditary paragangliomas, juvenile neuronal ceroid lipofuscinosis, malignant melanoma, protein C deficiency, and San Filippo disease. Many of these show a regional distribution, suggesting dissemination from a founder. Some mutations that occur among the Dutch are shared with other European populations and others have been transmitted by Dutch emigres to their descendents in North America and South Africa. The occurrence of short chromosomal regions that have remained identical by descent has resulted in relatively limited genetic heterogeneity for many genetic conditions among the Dutch. These observations demonstrate the opportunity for gene discovery for other diseases and traits in the Netherlands.},
 bibtype = {article},
 author = {Zeegers, M P and van Poppel, F and Vlietinck, R and Spruijt, L and Ostrer, H},
 journal = {Eur J Hum Genet},
 number = {7}
}

Paper  abstract   bibtex   

@article{riva_use_2003,
	title = {The use of the internet in psychological research: comparison of online and offline questionnaires.},
	volume = {6},
	issn = {1094-9313},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/12650565},
	abstract = {The Internet can be an effective medium for the posting, exchange, and collection of information in psychology-related research and data. The relative ease and inexpensiveness of creating and maintaining Web-based applications, associated with the simplicity of use via the graphic-user interface format of form-based surveys, can establish a new research frontier for the social and behavioral sciences. To explore the possible use of Internet tools in psychological research, this study compared Web-based assessment techniques with traditional paper-based methods of different measures of Internet attitudes and behaviors in an Italian sample. The collected data were analyzed to identify both differences between the two samples and in the psychometric characteristics of the questionnaires. Even if we found significant differences between the two samples in the Internet attitudes and behaviors, no relevant differences were found in the psychometric properties of the different questionnaires. This result, similar to the ones previously obtained in Web-based assessments of personality constructs, is even more interesting given the lack of control on the characteristics of the online sample. These finding suggests that, if sampling control and validity assessment is provided, Internet-based questionnaires can be a suitable alternative to more traditional paper-based measures.},
	number = {1},
	urldate = {2012-07-29},
	journal = {Cyberpsychology \& behavior : the impact of the Internet, multimedia and virtual reality on behavior and society},
	author = {Riva, Giuseppe and Teruzzi, Tiziana and Anolli, Luigi},
	month = feb,
	year = {2003},
	keywords = {Adolescent, Adult, Female, Humans, Internet, Male, Psychology, Psychology: instrumentation, Psychometrics, Psychometrics: instrumentation, Questionnaires, Research, Research: instrumentation},
	pages = {73--80},
}

Paper  abstract   bibtex   

@article{
 title = {A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor.},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {Adult,Chromosomes, Human, Pair 22,Ependymoma,Ependymoma: diagnosis,Ependymoma: genetics,Female,Genes, Neurofibromatosis 2,Germ-Line Mutation,Humans,Loss of Heterozygosity,Male,Microsatellite Repeats,Pedigree,Spinal Neoplasms,Spinal Neoplasms: genetics},
 pages = {598-602},
 volume = {48},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/14566482},
 month = {1},
 id = {27bbabe4-815b-349a-bf02-494ff0fc34a0},
 created = {2014-08-02T22:29:07.000Z},
 accessed = {2014-08-02},
 file_attached = {true},
 profile_id = {be299c88-7105-3a8d-a1cd-3aa95c25e2c4},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T21:45:19.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Familial ependymal tumors are a very rare disease, the pathogenesis of which is unknown. Previous studies indicate an involvement of tumor suppressor genes localized within chromosomal region 22q, whereas details are still unclear. Here we report a non-neurofibromatosis type-2 (non-NF2) Japanese family in which two of the four members are affected with cervical spinal cord ependymoma, and one of the four is affected with schwannoma. Loss of heterozygosity (LOH) studies were carried out searching for common allelic loss at chromosomal region 22q11.2-qtel in two of the affected patients. Our findings support a prediction for existence of a tumor suppressor gene on chromosome 22 especially related to the tumorigenesis of familial ependymal tumors.},
 bibtype = {article},
 author = {Yokota, Takashi and Tachizawa, Takayuki and Fukino, Koichi and Teramoto, Akira and Kouno, Jun and Matsumoto, Koshi and Emi, Mitsuru},
 journal = {Journal of human genetics},
 number = {11}
}

@Article{Ridker_2002_1393,
  author = {Ridker, P.M. and Rifai, N. and Rose, L. and Buring, J.E. and Cook, N.R.},
 journal = {New England Journal of Medicine},
 note = {Hl-43851/hl/nhlbi Hl-58755/hl/nhlbi Hl-63293/hl/nhlbi Comparative Study Evaluation Studies Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States},
 number = {20},
 pages = {1557-1565},
 title = {Comparison of {C}-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events},
 volume = {347},
 year = {2002},
 keywords = {Aged, Biological, Markers/blood, C-Reactive, Protein/*analysis, Cardiovascular, Diseases/blood/*epidemiology, Cholesterol, LDL/*blood, Disease-Free, Survival, Female, Hormone, Replacement, Therapy, Humans, Incidence, Longitudinal, Studies, Middle, Aged, Multivariate, Analysis, Prognosis, ROC, Curve, Risk, Risk, Factors},
 title_with_no_special_chars = {Comparison of Creactive protein and lowdensity lipoprotein cholesterol levels in the prediction of first cardiovascular events}
}

@article{schlienger_use_2002,
	title = {Use of nonsteroidal anti-inflammatory drugs and the risk of first-time acute myocardial infarction},
	volume = {54},
	issn = {0306-5251},
	abstract = {AIMS: Aspirin decreases the risk of clinical manifestations of atherothrombosis. This effect is mainly due to inhibition of platelet aggregation and potentially due to anti-inflammatory properties of aspirin. To evaluate whether use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) may also be associated with a decreased risk of first-time acute myocardial infarction (AMI), we performed a population-based case-control analysis using the United Kingdom-based General Practice Research Database (GPRD) METHODS: We identified first-time AMI-patients free of preexisting diagnosed cardiovascular or metabolic diseases. We compared use of NSAIDs prior to the index date between cases and control patients who were matched to cases on age, gender, practice and calendar time.
RESULTS: A total of 3319 cases ({\textless}or=75 years) with a diagnosis of first-time AMI between 1992 and 1997 and 13139 controls (matched to cases on age, sex, general practice attended, calendar time, years of prior history in the GPRD) were included. Overall, the relative risk estimate of AMI (adjusted for smoking, body mass index, hormone replacement therapy and aspirin) in current NSAID users was 1.17 (95\% CI 0.99, 1.37). Long-term current NSAID use ({\textgreater}or=30 prescriptions) yielded an adjusted odds ratio (OR) of 1.20 (95\% CI 0.94, 1.55). Stratification by age ({\textless}65 years vs{\textgreater}or=65 years) and sex did not materially change the results.
CONCLUSIONS: Our findings indicate that current NSAID exposure in patients free of diagnosed cardiovascular or metabolic conditions predisposing to cardiovascular diseases does not decrease the risk of AMI.},
	language = {eng},
	number = {3},
	journal = {British Journal of Clinical Pharmacology},
	author = {Schlienger, Raymond G. and Jick, Hershel and Meier, Christoph R.},
	month = sep,
	year = {2002},
	pmid = {12236854},
	pmcid = {PMC1874430},
	keywords = {Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Female, Great Britain, Humans, Male, Middle Aged, Myocardial Infarction, Risk Assessment, Risk Factors},
	pages = {327--332}
}

@article{behrmann_eye_2001,
	title = {The eye movements of pure alexic patients during reading and nonreading tasks},
	volume = {39},
	abstract = {We compared the eye-movements of two patients who read letter-by-letter (LBL) following a left occipital lobe lesion with those of normal control subjects and of hemianopic patients in two tasks: a nonreading visual search task and a text reading task. Whereas the LBL readers exhibited similar eye-movement patterns to those of the other two groups on the nonreading task, their eye movements differed significantly during reading, as reflected in the disproportionate increase in the number and duration of fixations per word and in the regressive saccades per word. Importantly, relative to the two control groups, letter-by-letter readers also made more fixations per word as word length increased, especially as word frequency and word imageability decreased. Two critical results emerged from these experiments: First, the alteration in the oculomotor behavior of the LBL readers during reading is similar to that seen in normal readers under difficult reading conditions, as well as in beginning readers and in those with developmental dyslexia, and appears to reflect difficulties in processing the visual stimulus. Second, the interaction of length with frequency and with imageability in determining the eye movement pattern is consistent with an interactive activation model of normal word recognition in which weakened activation of orthographic input can nevertheless engage high-level lexical factors.},
	number = {9},
	journal = {Neuropsychologia},
	author = {Behrmann, M and Shomstein, S S and Black, S E and Barton, J J},
	year = {2001},
	pmid = {11516450},
	keywords = {*Eye Movements, *Reading, Adult, Comparative Study, Dyslexia/*physiopathology, Female, Hemianopsia/physiopathology, Humans, Male, Middle Aged, Occipital Lobe/*physiology, Recognition (Psychology), Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.},
	pages = {983--1002},
}

Website  abstract   bibtex   

@article{
 title = {Grounding spatial language in perception: an empirical and computational investigation.},
 type = {article},
 year = {2001},
 identifiers = {[object Object]},
 keywords = {Adult,Discrimination Learning,Female,Humans,Male,Orientation,Pattern Recognition, Visual,Psycholinguistics,Semantics,Space Perception,Verbal Learning},
 pages = {273-98},
 volume = {130},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11409104},
 month = {6},
 id = {f03a3f85-fc38-3a50-8e63-ac6586b9fb9c},
 created = {2017-09-01T15:53:20.987Z},
 accessed = {2016-01-30},
 file_attached = {false},
 profile_id = {80da7853-f7b7-36a9-8e4c-d7ddb2d9e538},
 group_id = {a2333ea3-15a4-3d40-8d36-f0d9590ca926},
 last_modified = {2017-09-01T15:53:21.069Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Regier2001},
 abstract = {The present paper grounds the linguistic cdategorization of space in aspects of visual perception; specifically, the structure of projective spatial terms such as above are grounded in the process of attention and in vector-sum coding of overall direction. This is formalized in the attentional vector-sum (AVS) model. This computational model accurately predicts linguistic acceptability judgments for spatial terms, under a variety of spatial configurations. In 7 experiments, the predictions of the AVS model are tested against those of 3 competing models. The results support the AVS model and disconfirm its competitors. The authors conclude that the structure of linguistic spatial categories can be partially explained in terms of independently motivated perceptual processes.},
 bibtype = {article},
 author = {Regier, T and Carlson, L A},
 journal = {Journal of experimental psychology. General},
 number = {2}
}

Paper  abstract   bibtex   

@article{krause_effects_2000,
	title = {The effects of memory load on event-related {EEG} desynchronization and synchronization.},
	volume = {111},
	issn = {1388-2457},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11068244},
	abstract = {OBJECTIVES: To examine the effects of working memory load on the event-related desynchronization (ERD) and synchronization (ERS) of several narrow EEG frequency bands.

METHODS: ERD/ERS responses of the 4-6, 6-8, 8-10 and 10-12 Hz EEG frequency bands were studied in 24 normal subjects performing a visual sequential letter task (so-called n-back task) in which memory load was varied from 0 to 2.

RESULTS: In the 4-6 Hz theta frequency band, a long-lasting synchronization was observed in the anterior electrodes, especially after the presentation of targets. In the 6-8 and 8-10 Hz frequency bands, anterior ERS was elicited especially in the 2-back condition (highest memory load). In contrast to the responses of the 8-10 Hz frequency band, in the 10-12 Hz frequency band the 2-back experimental condition elicited the greatest ERD.

CONCLUSIONS: In the highest memory load (2-back) experimental condition the attentional capacities were most probably exceeded, resulting in 6-8 and 8-10 Hz ERS. This might reflect an inhibition of such brain areas (frontal cortices) no longer involved in task completion when alternative strategies are needed and utilized. These more 'cognitive' strategies were then reflected as an increase in 10-12 Hz ERD. Additionally, our results support the assumption that the simultaneously recorded ERD/ERS responses of different narrow EEG frequency bands differ and reflect distinct aspects of information processing.},
	number = {11},
	urldate = {2015-05-08},
	journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
	author = {Krause, C M and Sillanmäki, L and Koivisto, M and Saarela, C and Häggqvist, A and Laine, M and Hämäläinen, H},
	month = nov,
	year = {2000},
	pmid = {11068244},
	keywords = {Adult, Brain, Brain: physiology, Cortical Synchronization, Electroencephalography, Evoked Potentials, Evoked Potentials: physiology, Female, Humans, Male, Memory, Memory: physiology},
	pages = {2071--8},
}

@article{van_staa_oral_2000,
	title = {Oral corticosteroids and fracture risk: relationship to daily and cumulative doses},
	volume = {39},
	issn = {1462-0324},
	shorttitle = {Oral corticosteroids and fracture risk},
	abstract = {OBJECTIVE: This study examined the effects of daily and cumulative oral corticosteroid doses on the risk of fractures.
METHODS: Information was obtained from the General Practice Research Database, which contains medical records of general practitioners in England and Wales. The study included 244 235 oral corticosteroid users and 244 235 controls.
RESULTS: Patients taking higher doses (at least 7. 5 mg daily of prednisolone or equivalent) had significantly increased risks of non-vertebral fracture [relative rate (RR)=1.44, 95\% confidence interval (CI) 1.34-1.54], hip fracture (RR=2.21, 95\% CI 1.85-2.64) and vertebral fracture (RR=2.83, 95\% CI 2.35-2.40) relative to patients using oral corticosteroids at lower doses (less than 2.5 mg per day). Fracture risk was also elevated among people with higher cumulative exposure to oral corticosteroids over the study period, but this effect was almost wholly removed by adjustment for daily dose, age, gender and other confounding variables.
CONCLUSIONS: These findings suggest that the adverse skeletal effects of oral corticosteroids manifest rapidly and are related to daily dose. The level of previous exposure to oral corticosteroids was not a strong determinant of the risk of fracture. Preventive measures against corticosteroid-induced osteoporosis should therefore be instituted as soon after the commencement of glucocorticoid therapy as possible.},
	language = {eng},
	number = {12},
	journal = {Rheumatology (Oxford, England)},
	author = {van Staa, T. P. and Leufkens, H. G. and Abenhaim, L. and Zhang, B. and Cooper, C.},
	month = dec,
	year = {2000},
	pmid = {11136882},
	keywords = {Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Dose-Response Relationship, Drug, Female, Fractures, Bone, Humans, Middle Aged, Osteoporosis, Registries, Risk Factors},
	pages = {1383--1389}
}

Website  abstract   bibtex   

@article{
 title = {Multivariate frailty model with a major gene: application to genealogical data},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {*Genetic Predisposition to Disease,*Models, Genetic,Adolescent,Adult,Alleles,Child,Child, Preschool,Female,Genotype,Humans,Infant,Infant, Newborn,Longevity/*genetics,Male,Mathematical Computing,Multivariate Analysis,Quebec,Risk,Software,Survival Analysis},
 pages = {412-416},
 volume = {77},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11187585},
 id = {23588418-0e3c-33dd-b0e4-fed475556b34},
 created = {2017-06-19T13:44:21.917Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:22.080Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0926-9630<m:linebreak/>Journal Article</m:note>},
 abstract = {Multivariate survival models are shown to be appropriate for the analysis of the genetic and the environmental nature of a human life-span. Models which involve continuously distributed individual frailty, play an important role in the genetic analysis of an individual's susceptibility to disease and death. These models, however, are not appropriate for the detection of the effects of separate genes on survival. For this purpose we developed a 'major gene' frailty model of multivariate survival and applied it to simulated and real pedigree data. The analysis shows that this model can be used for the detection of the presence of major genes in the population and for the evaluation of the effects of such genes on survival.},
 bibtype = {article},
 author = {Begun, A and Desjardins, B and Iachine, I and Yashin, A},
 journal = {Stud Health Technol Inform}
}

@Article{Thoroughman2000,
  author   = {KA Thoroughman and R Shadmehr},
  journal  = {Nature},
  title    = {Learning of action through adaptive combination of motor primitives.},
  year     = {2000},
  number   = {6805},
  pages    = {742-7},
  volume   = {407},
  abstract = {Understanding how the brain constructs movements remains a fundamental
	challenge in neuroscience. The brain may control complex movements
	through flexible combination of motor primitives, where each primitive
	is an element of computation in the sensorimotor map that transforms
	desired limb trajectories into motor commands. Theoretical studies
	have shown that a system's ability to learn action depends on the
	shape of its primitives. Using a time-series analysis of error patterns,
	here we show that humans learn the dynamics of reaching movements
	through a flexible combination of primitives that have gaussian-like
	tuning functions encoding hand velocity. The wide tuning of the inferred
	primitives predicts limitations on the brain's ability to represent
	viscous dynamics. We find close agreement between the predicted limitations
	and the subjects' adaptation to new force fields. The mathematical
	properties of the derived primitives resemble the tuning curves of
	Purkinje cells in the cerebellum. The activity of these cells may
	encode primitives that underlie the learning of dynamics.},
  doi      = {10.1038/35037588},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, 11048700},
}

@article{dicarlo_velocity_1999,
	title = {Velocity invariance of receptive field structure in somatosensory cortical area 3b of the alert monkey.},
	volume = {19},
	abstract = {This is the second in a series of studies of the neural representation of tactile spatial form in cortical area 3b of the alert monkey. We previously studied the spatial structure of 330 area 3b neuronal receptive fields (RFs) on the fingerpad with random dot patterns scanned at one velocity (40 mm/sec; ). Here, we analyze the temporal structure of 84 neuronal RFs by studying their spatial structure at three scanning velocities (20, 40, and 80 mm/sec). As in the previous study, most RFs contained a single, central, excitatory region and one or more surrounding or flanking inhibitory regions. The mean time delay between skin stimulation and its excitatory effect was 15.5 msec. Except for differences in mean rate, each neuron's response and the spatial structure of its RF were essentially unaffected by scanning velocity. This is the expected outcome when excitatory and inhibitory effects are brief and synchronous. However, that interpretation is consistent neither with the reported timing of excitation and inhibition in somatosensory cortex nor with the third study in this series, which investigates the effect of scanning direction and shows that one component of inhibition lags behind excitation. We reconcile these observations by showing that overlapping (in-field) inhibition delayed relative to excitation can produce RF spatial structure that is unaffected by changes in scanning velocity. Regardless of the mechanisms, the velocity invariance of area 3b RF structure is consistent with the velocity invariance of tactile spatial perception (e.g., roughness estimation and form recognition).},
	language = {eng},
	number = {1},
	journal = {J Neurosci},
	author = {DiCarlo, J J and Johnson, K O},
	year = {1999},
	pmid = {9870969},
	note = {Place: UNITED STATES
ISBN: 0270-6474},
	keywords = {Adaptation, Physiological, Animals, Brain Mapping, Cortical Synchronization, Evoked Potentials, Female, Macaca mulatta, Male, Neural Inhibition, Somatosensory Cortex, Visual Fields, comparative study, research support, non-u.s. gov't, research support, u.s. gov't, p.h.s.},
	pages = {401--419},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry},
 type = {article},
 year = {1999},
 identifiers = {[object Object]},
 keywords = {Base Sequence,Canada,Canada/ethnology,Canada: ethnology,DNA-Binding Proteins,DNA-Binding Proteins/*genetics,DNA-Binding Proteins: genetics,Ethnic Groups,Ethnic Groups/*genetics,Ethnic Groups: genetics,Female,France,France/ethnology,France: ethnology,Human,Humans,Louisiana,Male,Microsatellite Repeats,Microsatellite Repeats/*genetics,Microsatellite Repeats: genetics,Muscular Dystrophies,Muscular Dystrophies/*genetics,Muscular Dystrophies: genetics,Non-U.S. Gov't,Pedigree,Poly(A)-Binding Protein II,Support},
 pages = {477-481},
 volume = {86},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/10508991},
 month = {10},
 day = {29},
 id = {45d065a8-6799-3e6b-880b-3fa24b3356fa},
 created = {2017-06-19T13:42:02.365Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:42:02.505Z},
 tags = {04/09/07},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>        <m:bold>From Duplicate 1 ( </m:bold>                <m:bold>          </m:bold><m:bold><m:italic>Unique PABP2 mutations in &quot;Cajuns&quot; suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry</m:italic></m:bold><m:bold>        </m:bold>                <m:bold> - Scacheri, P C; Garcia, C; Hebert, R; Hoffman, E P )<m:linebreak/>        </m:bold>        <m:linebreak/>Journal Article<m:linebreak/>        <m:linebreak/>      </m:note>},
 abstract = {Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset autosomal dominant myopathy found world-wide, but with the highest incidence in French-Canadians. Short GCG expansions in the poly(A) binding protein 2 (PABP2) gene were identified recently as the molecular basis for OPMD in French-Canadians. All French-Canadian cases of OPMD have been traced to a single founder couple [Bouchard, 1997: Neuromuscul Disord 7(Suppl):S5-S11]. Cultural links between French-Canadians and Cajuns suggest that this same founder couple may have transmitted the OPMD mutation to Cajuns as well. To determine if OPMD patients from Louisiana share a founder effect with French-Canadian families, we collected blood samples and muscle biopsies from several Cajuns with OPMD for mutation and linkage studies. We found a unique 'GCA GCG GCG' insertion mutation in Cajuns. Consistent with these sequence data, we identified a disease haplotype in our Cajun families that is different from the ancestral haplotype defined in French-Canadians. These data prove that different founders introduced the PABP2 mutation to Cajuns and French-Canadians and lend support to emerging genealogical data suggesting that French-Canadians and Cajuns represent distinct immigrant groups from France.},
 bibtype = {article},
 author = {Scacheri, P C and Garcia, C and Hébert, R and Hoffman, E P and Hebert, R},
 journal = {Am J Med Genet},
 number = {5}
}

@article{
 title = {Visual-proprioceptive mapping in children with developmental coordination disorder},
 type = {article},
 year = {1999},
 identifiers = {[object Object]},
 keywords = {Case-Control Studies,Child,Female,Growth Disorders,Humans,Male,Motor Skills,Preschool,Proprioception,Vision,physiopathology,psychology},
 pages = {247-254},
 volume = {41},
 id = {2a1d6312-9620-3630-b63f-f17c2d8e07ef},
 created = {2016-01-12T14:17:48.000Z},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Developmental coordination disorder (DCD) occurs in a small but significant proportion of children who present with impaired body-eye coordination and show poor acquisition of motor skills. This study investigated the visual-proprioceptive mapping ability of children with DCD from a small selected group, with particular reference to the use of vision in matching tasks. The children with DCD in this study were significantly poorer than control children on all matching tasks. They seemed to have particular difficulty in cross-modal judgements that required the use of visual information to guide proprioceptive judgements of limb position. A distinction is drawn between tasks that can be achieved purely through sensory matching and those that require body-centred spatial judgements, suggesting that it is the latter that posits a particular difficulty for children with DCD},
 bibtype = {article},
 author = {Mon-Williams, M A and Wann, J P and Pascal, E},
 journal = {Developmental Medicine & Child Neurology},
 number = {4}
}

@article{hippisley-cox_are_1998,
	title = {Are spouses of patients with hypertension at increased risk of having hypertension? {A} population-based case-control study},
	volume = {48},
	issn = {0960-1643},
	shorttitle = {Are spouses of patients with hypertension at increased risk of having hypertension?},
	abstract = {BACKGROUND: Studies of couples, who tend to share an environment but are genetically dissimilar, can shed light on the contribution of environmental factors to hypertension. There has been renewed interest in these environmental factors following the re-analysis of the INTERSALT study.
AIM: To determine whether patients whose spouses have hypertension are at increased risk of hypertension, using a population-based case-control study.
METHOD: The total study population consisted of all 3923 patients over 30 years old registered with one general practice. Male cases with hypertension were matched to male controls without hypertension. Female cases with hypertension were matched to female controls without hypertension. The variables were: diagnosed hypertension; having a spouse with diagnosed hypertension; age; sex; weight; height; body-mass index; couple status; diabetes; and systolic and diastolic blood pressure readings.
RESULTS: On multivariate analysis, when age, body-mass index, diabetes, couple status, and having a blood pressure reading were included, men whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted odds ratio (OR) 2.24; 95\% CI 1.77-2.72; P = 0.001). Similarly, on multivariate analysis, women whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted OR = 2.23; 95\% CI 1.75-2.72; P = 0.001). The risk for both male and female subjects persisted after adjustment for other variables. There was a significant correlation between systolic (r = 0.41; P {\textless} 0.0001) and diastolic (r = 0.25; P {\textless} 0.0001) blood pressures between spouse pairs.
CONCLUSION: The independent association between having a spouse with hypertension and increased risk of hypertension supports the view that there are significant environmental factors in the aetiology of hypertension. The finding has implications for the screening and treatment of hypertension in primary care.},
	language = {eng},
	number = {434},
	journal = {The British Journal of General Practice: The Journal of the Royal College of General Practitioners},
	author = {Hippisley-Cox, J. and Pringle, M.},
	month = sep,
	year = {1998},
	pmid = {9830183},
	pmcid = {PMC1313221},
	keywords = {Adult, Analysis of Variance, Case-Control Studies, England, Female, Humans, Hypertension, Male, Risk Assessment, Risk Factors, Rural Health, Spouses},
	pages = {1580--1583}
}

@article{van_staa_postmarketing_1998,
	title = {Postmarketing surveillance of the safety of cyclic etidronate},
	volume = {18},
	issn = {0277-0008},
	abstract = {To evaluate the safety of cyclic etidronate in routine clinical practice, we obtained information from 550 general practices in the United Kingdom that provide the medical records to the General Practice Research Database. A group of 7977 patients taking cyclic etidronate and two age-, gender-, and practice-matched control groups, one with osteoporosis and one without, were analyzed. For the group taking cyclic etidronate, the average age was 71.6 years and follow-up was 10,328 person-years. Conditions that do not induce osteoporosis generally occurred in these patients at a rate comparable to that in the control groups. The incidence of osteomalacia was low and comparable between patients taking cyclic etidronate and controls with osteoporosis. No medically significant increases in frequency were observed among patients taking cyclic etidronate for a broad group of diseases that may potentially be induced by exposure to the drug. These data support the favorable risk:benefit ratio of cyclic etidronate.},
	language = {eng},
	number = {5},
	journal = {Pharmacotherapy},
	author = {van Staa, T. P. and Leufkens, H. and Abenhaim, L. and Cooper, C.},
	month = oct,
	year = {1998},
	pmid = {9758324},
	keywords = {Aged, Cohort Studies, Etidronic Acid, Female, Great Britain, Humans, Male, Osteoporosis, Product Surveillance, Postmarketing, Quality Control, Retrospective Studies},
	pages = {1121--1128}
}

@article{
 title = {The twinning rates and epidemiological characteristics of births in southeast Uttar Pradesh, India},
 type = {article},
 year = {1997},
 identifiers = {[object Object]},
 keywords = {Adult,Birth Rate,Female,Human,India/epidemiology,Maternal Age,Parity,Pregnancy,Pregnancy Complications/*epidemiology,Pregnancy, Multiple/*statistics & numerical data,Seasons,Twins, Dizygotic,Twins, Monozygotic,Twins/*statistics & numerical data},
 pages = {47-56},
 volume = {46},
 id = {529933bb-e6ef-3768-86f0-68daccc174e2},
 created = {2017-06-19T13:43:38.550Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:38.682Z},
 tags = {03/11/06},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>Journal Article<m:linebreak/>Twin Study</m:note>},
 abstract = {Birth statistics over a period of 5 years were analyzed to study epidemiological characteristics of twinning in Southeast Uttar Pradesh, India. The data revealed higher incidence of breech twins (11.84% of all cotwins) as compared to breech single births (2.18%). But the perinatal mortality and caesarean section rates were similar in both twin and singleton pregnancies. The cumulative twinning rate over the studied period was 11.70 per 1000 live births. The MZ and DZ twinning rates were estimated respectively as 3.67 and 8.03 per mill. The mean maternal age of sampled mothers was 26.42 years with one standard deviation of 5.30 years. The twinning rate for mothers over 35 years of age was about four times higher than that in mothers younger than 20 years. Incidentally, the twinning rate was the highest at parity four and a non-linear curve could more appropriately be fitted to the series of data. Seasonal variations were observed for both twin and singleton births. The highest frequency of births was observed from August through October. But seasonal index for twinning rate showed a clear bimodal distribution with peaks in April (223) and September (167).},
 bibtype = {article},
 author = {Sharma, K},
 journal = {Acta Genet Med Gemellol (Roma)},
 number = {1}
}

Website  abstract   bibtex   

@article{
 title = {Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group},
 type = {article},
 year = {1996},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Age Distribution,Aged,Aged, 80 and over,Allergens/diagnostic use,Asthma/epidemiology/*genetics,Atlantic Ocean,Bronchoconstrictor Agents/diagnostic use,Child,Child, Preschool,Consanguinity,Female,Forced Expiratory Volume,Founder Effect,Humans,Linkage (Genetics),Male,Methacholine Chloride/diagnostic use,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Sex Distribution,Skin Tests},
 pages = {1902-1906},
 volume = {153},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8665053},
 id = {ba377ad3-36ac-3937-b8d3-44f6b08c99e3},
 created = {2017-06-19T13:44:45.103Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:45.287Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1073-449x<m:linebreak/>Journal Article</m:note>},
 abstract = {Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus increasing the probability of gene localization. We studied the inbred population of the remote island of Tristan da Cunha to document asthma prevalence for the purpose of genetic linkage analysis. Medical histories and skin atopy were determined on 282 islanders, representing 97% of the population, and airway responsiveness was measured in 254; 226 by methacholine challenge (tidal breathing method) and 28 by bronchodilator response (400 micrograms salbutamol aerosol). Blood samples were collected from 275 islanders. Participants ranged in age from 3 to 94 yr. Asthma was defined as increased airway responsiveness (AR+: PC20 < 4 mg/ml or > or = 15% increase in FEV1 postbronchodilator) combined with a positive history (Hx+). Fifty-seven percent of the islanders had at least partial evidence of asthma (Hx+ and/or AR+) and 23% had a definitive diagnosis of asthma (AR+ with Hx+). Overall 47% of the population were atopic, atopy was proportionally higher in asthmatics (74%) than nonasthmatics (32%; p < 0.01). Analysis of the methacholine dose-response curves demonstrated that asthmatics were significantly (p < 0.01) more responsive than those with AR+ only, and nonasthmatics (AR-, Hx-) were more responsive than laboratory control subjects (p < 0.05), suggesting that these islanders may also carry an airway hyperresponsiveness gene. A frequency plot of the percent fall in FEV1 for all Hx- subjects compared with control data suggests a bimodal distribution consistent with a major gene mechanism for airway responsiveness. Genealogy mapping revealed that the islanders are direct descendants of the 15 original settlers, and historical records suggest at least two founders may have been asthmatic. The data confirm previous reports of a high asthma prevalence on Tristan and support the postulate that this prevalence is a result of gene enrichment occurring in isolated populations by virtue of extensive inbreeding and a probable founder effect.},
 bibtype = {article},
 author = {Zamel, N and McClean, P A and Sandell, P R and Siminovitch, K A and Slutsky, A S},
 journal = {Am J Respir Crit Care Med},
 number = {6 Pt 1}
}

@Article{Kitzes1996,
  author   = {LM Kitzes and GS Hollrigel},
  journal  = {Hear Res},
  title    = {Response properties of units in the posterior auditory field deprived of input from the ipsilateral primary auditory cortex.},
  year     = {1996},
  note     = {as cited in \citeNP{Heil1998}},
  number   = {1-2},
  pages    = {120-30},
  volume   = {100},
  abstract = {The influence of the ipsilateral primary auditory field (AI) on the
	response properties of neurons in the posterior auditory field (Field
	P) was examined in three cats anesthetized with sodium pentobarbital.
	Rate/level functions were obtained, by extracellular recording, from
	single units in Field P before (n = 38) and after (n = 50) subpial
	aspiration of AI. The ablations were primarily confined to the medial
	ectosylvian gyrus, although in one case extended into the high-frequency
	portion of the anterior auditory field. Comparisons between the behavior
	of units isolated before and after AI ablation failed to demonstrate
	any changes in the response properties of neurons in Field P attributable
	to the ablation. Nonmonotonic response profiles, first spike latency,
	variability in latency, threshold and maximal discharge rates of
	the units to acoustic stimuli were not significantly altered by the
	AI ablation. These results indicate that the basic response properties
	of neurons in Field P do not depend on input from the ipsilateral
	AI. This suggests that these properties are most likely determined
	by thalamic input or by circuitry within Field P.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, 8922986},
}

@Article{Bavelier1994,
  author   = {D Bavelier},
  journal  = {Cognition},
  title    = {Repetition blindness between visually different items: {T}he case of pictures and words.},
  year     = {1994},
  number   = {3},
  pages    = {199-236},
  volume   = {51},
  abstract = {Repetition blindness (RB) is the failure to see or recall the second
	of two visually similar or identical items in rapid serial visual
	presentation. It was initially demonstrated by Kanwisher (1987),
	who proposed that a second token of a given word or object type cannot
	be established when the two items occur close in time. Bavelier and
	Potter (1992) showed that RB also occurs between visually different
	items that are phonologically similar. They proposed that RB may
	occur not only when the targets are physically similar, but also
	when they have to be registered or encoded in short-term memory (STM)
	along dimensions on which they are similar. This hypothesis predicts
	that RB between visually different items should not be restricted
	to words, but should occur with any stimuli, as long as the task
	requires these stimuli to be encoded along dimensions on which they
	are similar. Moreover, it also implies that a task that changes the
	preferred code of targets will affect the size of RB. The first prediction
	was confirmed by establishing RB between phonologically similar pictures
	and words, whether semantically related (the picture of a cat and
	the word "cat") or not (the picture of a sun and the word "son"),
	when using a task that requires phonological encoding (Experiments
	1 and 2). The second prediction was also supported: the magnitude
	of RB depended on whether the task required similar or different
	codes for pictures and words (Experiments 3 and 4). These experiments
	confirm that RB between visually different items is due to the similarity
	of the codes initially used in STM. The results suggest that RB can
	occur at any step during the instantiation of a token, arising not
	only from a failure to create a new token, but also from a failure
	to stabilize an opened token. In this view, tokens are to be seen
	as dynamical entities, built over time as a function of type activation
	and task requirements, and varying in stability as a function of
	the information that is entered into them.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, 8194301},
}

@article{chandler_minimum_1992,
	title = {Minimum audible movement angle in the horizontal plane as a function of stimulus frequency and bandwidth, source azimuth, and velocity},
	volume = {91},
	abstract = {Minimum audible movement angles (MAMAs) were measured in the horizontal plane for four normal-hearing adult subjects in a darkened anechoic chamber. On each trial, a single stimulus was presented, and the subject had to say whether it came from a stationary loudspeaker or from a loudspeaker that was moving at a constant angular velocity around him. Thresholds were established by adaptively varying stimulus duration. In experiment 1, MAMAs were measured as a function of center frequency (500-5000 Hz), velocity (10 degrees-180 degrees/s), and direction of motion (left versus right). There was no effect of direction of motion. MAMAs increased with velocity, from an average of 8.8 degrees of arc for a target moving at 10 degrees/s to an average of 20.2 degrees of arc for a target moving at 180 degrees/s. MAMAs were higher for a 3000-Hz tone than for tones of lower or higher frequencies, as has been previously reported [D. R. Perrott and J. Tucker, J. Acoust. Soc. Am. 83, 1522-1527 (1988)]. In experiment 2, minimum audible angles (MAAs) were measured with sequentially presented stationary tone pulses (500-5000 Hz), and were shown to exhibit the same dependence on signal frequency that the MAMAs showed (average MAA at 3000 Hz: 8.4 degrees; average MAA at the other frequencies: 3.4 degrees). In experiment 3, MAMAs and MAAs were measured as a function of stimulus bandwidth (centered at 3000 Hz) and listening azimuth (0 degrees vs 60 degrees). Average MAAs decreased monotonically as stimulus bandwidth increased from 0 Hz to wideband (from 8.4 degrees to 1.2 degrees at 0 degrees azimuth; from 11.3 degrees to 1.5 degrees at 60 degrees azimuth). As in experiment 1, MAMAs increased with stimulus velocity, from values comparable to the MAAs for the slowest-velocity (10 degrees/s) targets to 70 degrees of arc or more in the poorest condition (third-octave band of noise presented at a velocity of 180 degrees/s and an azimuth of 60 degrees). MAMAs obtained in the slower-velocity conditions depended in the same way on stimulus bandwidth and listening azimuth that MAAs depended on these variables. In no case was the MAMA ever smaller than the MAA. It is hypothesized that a minimum integration time is required to achieve optimal performance in a dynamic spatial resolution task. Average estimates of this minimum time based on the current data vary from 336 ms (for targets presented at midline) to 1116 ms (for narrow-band targets presented at 60 degrees azimuth).(ABSTRACT TRUNCATED AT 400 WORDS)},
	number = {3},
	journal = {J Acoust Soc Am},
	author = {Chandler, D W and Grantham, D W},
	year = {1992},
	pmid = {1564199},
	keywords = {*Attention, *Loudness Perception, *Orientation, *Pitch Discrimination, *Sound Localization, Adult, Auditory Threshold, Dichotic Listening Tests, Female, Humans, Male, Psychoacoustics, Research Support, U.S. Gov't, P.H.S.},
	pages = {1624--1636},
}

Paper  abstract   bibtex   

@article{lincoln_serum_1990,
	title = {Serum ionized calcium concentration in clinically normal dairy cattle, and changes associated with calcium abnormalities.},
	volume = {197},
	issn = {0003-1488},
	url = {http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=2272878&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum},
	abstract = {Serum ionized calcium (ICa) concentration was determined in 141 clinically normal dairy cattle by use of a direct-measuring calcium ion-selective electrode instrument. Mean serum ICa concentration 2 hours after blood withdrawal was 4.59 mg/dl; range varied from 3.79 to 5.25 mg/dl. Regression analysis indicated a high degree of correlation between ICa and serum total calcium concentrations if serum stored at 23 C was analyzed within 12 hours after blood withdrawal. Abnormal ICa concentration was detected in 19 of 85 dairy cows that were affected with various pathologic conditions. All 19 cows had hypocalcemia (n = 13 with parturient hypocalcemia, 4 with hypomagnesemic tetany, and 2 with renal disease). In all cases, the ICa concentration clearly related to the clinical manifestation of disease and the functional status of the cow's calcium metabolism.},
	number = {11},
	journal = {Journal of the American Veterinary Medical Association},
	author = {Lincoln, S D and Lane, V M},
	month = dec,
	year = {1990},
	keywords = {Animals, Calcium, Cattle, Cattle Diseases, Female, Hydrogen-Ion Concentration, Hypocalcemia, Lactation, Potentiometry, Reference Values, Regression Analysis},
	pages = {1471--4}
}