@article{pellerin_deep_2023,
	title = {Deep {Intronic} {FGF14} {GAA} {Repeat} {Expansion} in {Late}-{Onset} {Cerebellar} {Ataxia}.},
	volume = {388},
	copyright = {Copyright (c) 2022 Massachusetts Medical Society.},
	issn = {1533-4406 0028-4793},
	doi = {10.1056/NEJMoa2207406},
	abstract = {BACKGROUND: The late-onset cerebellar ataxias (LOCAs) have largely resisted molecular diagnosis. METHODS: We sequenced the genomes of six persons with autosomal dominant LOCA who were members of three French Canadian families and identified a candidate pathogenic repeat expansion. We then tested for association between the repeat expansion and disease in two independent case-control series - one French Canadian (66 patients and 209 controls) and the other German (228 patients and 199 controls). We also genotyped the repeat in 20 Australian and 31 Indian index patients. We assayed gene and protein expression in two postmortem cerebellum specimens and two induced pluripotent stem-cell (iPSC)-derived motor-neuron cell lines. RESULTS: In the six French Canadian patients, we identified a GAA repeat expansion deep in the first intron of FGF14, which encodes fibroblast growth factor 14. Cosegregation of the repeat expansion with disease in the families supported a pathogenic threshold of at least 250 GAA repeats ([GAA]{\textgreater}/=250). There was significant association between FGF14 (GAA){\textgreater}/=250 expansions and LOCA in the French Canadian series (odds ratio, 105.60; 95\% confidence interval [CI], 31.09 to 334.20; P{\textless}0.001) and in the German series (odds ratio, 8.76; 95\% CI, 3.45 to 20.84; P{\textless}0.001). The repeat expansion was present in 61\%, 18\%, 15\%, and 10\% of French Canadian, German, Australian, and Indian index patients, respectively. In total, we identified 128 patients with LOCA who carried an FGF14 (GAA){\textgreater}/=250 expansion. Postmortem cerebellum specimens and iPSC-derived motor neurons from patients showed reduced expression of FGF14 RNA and protein. CONCLUSIONS: A dominantly inherited deep intronic GAA repeat expansion in FGF14 was found to be associated with LOCA. (Funded by Fondation Groupe Monaco and others.).},
	language = {eng},
	number = {2},
	journal = {The New England journal of medicine},
	author = {Pellerin, David and Danzi, Matt C. and Wilke, Carlo and Renaud, Mathilde and Fazal, Sarah and Dicaire, Marie-Josee and Scriba, Carolin K. and Ashton, Catherine and Yanick, Christopher and Beijer, Danique and Rebelo, Adriana and Rocca, Clarissa and Jaunmuktane, Zane and Sonnen, Joshua A. and Lariviere, Roxanne and Genis, David and Molina Porcel, Laura and Choquet, Karine and Sakalla, Rawan and Provost, Sylvie and Robertson, Rebecca and Allard-Chamard, Xavier and Tetreault, Martine and Reiling, Sarah J. and Nagy, Sara and Nishadham, Vikas and Purushottam, Meera and Vengalil, Seena and Bardhan, Mainak and Nalini, Atchayaram and Chen, Zhongbo and Mathieu, Jean and Massie, Rami and Chalk, Colin H. and Lafontaine, Anne-Louise and Evoy, Francois and Rioux, Marie-France and Ragoussis, Jiannis and Boycott, Kym M. and Dube, Marie-Pierre and Duquette, Antoine and Houlden, Henry and Ravenscroft, Gianina and Laing, Nigel G. and Lamont, Phillipa J. and Saporta, Mario A. and Schule, Rebecca and Schols, Ludger and La Piana, Roberta and Synofzik, Matthis and Zuchner, Stephan and Brais, Bernard},
	month = jan,
	year = {2023},
	pmid = {36516086},
	pmcid = {PMC10042577},
	note = {Place: United States},
	keywords = {*Cerebellar Ataxia/genetics/pathology, *DNA Repeat Expansion/genetics, *Introns/genetics, Australia, Canada, Friedreich Ataxia/genetics/pathology, Humans},
	pages = {128--141},
}

@article{shi_understanding_2023,
	title = {Understanding the risk of transmission of respiratory viral infections in childcare centres: protocol for the {DISeases} {TrANsmission} in {ChildcarE} ({DISTANCE})  multicentre cohort study.},
	volume = {10},
	copyright = {© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.},
	issn = {2052-4439},
	doi = {10.1136/bmjresp-2023-001617},
	abstract = {INTRODUCTION: Childcare centre is considered a high-risk setting for transmission of respiratory viruses. Further evidence is needed to understand the risk of  transmission in childcare centres. To this end, we established the DISeases  TrANsmission in ChildcarE (DISTANCE) study to understand the interaction among  contact patterns, detection of respiratory viruses from environment samples and  transmission of viral infections in childcare centres. METHODS AND ANALYSIS: The  DISTANCE study is a prospective cohort study in multiple childcare centres of  Jiangsu Province, China. Study subjects will be childcare attendees and teaching  staff of different grades. A range of information will be collected from the  study subjects and participating childcare centres, including attendance, contact  behaviours (collected by onsite observers), respiratory viral infection (weekly  respiratory throat swabs tested by multiplex PCR), presence of respiratory  viruses on touch surfaces of childcare centres and weekly follow-up survey on  respiratory symptoms and healthcare seeking among subjects tested positive for  any respiratory viruses. Detection patterns of respiratory viruses from study  subjects and environment samples, contact patterns, and transmission risk will be  analysed by developing statistical and mathematical models as appropriate. The  study has been initiated in September 2022 in 1 childcare centre in Wuxi City,  with a total of 104 children and 12 teaching staff included in the cohort; data  collection and follow-up is ongoing. One more childcare centre in Nanjing City  (anticipated to include 100 children and 10 teaching staff) will start  recruitment in 2023. ETHICS AND DISSEMINATION: The study has received ethics  approval from Nanjing Medical University Ethics Committee (No. 2022-936) and  ethics approval from Wuxi Center for Disease Control and Prevention Ethics  Committee (No. 2022-011). We plan to disseminate the study findings mainly  through publications in peer-reviewed journals and presentations in academic  conferences. Aggregated research data will be shared freely to researchers.},
	language = {eng},
	number = {1},
	journal = {BMJ open respiratory research},
	author = {Shi, Chao and Wang, Xin and Ye, Sheng and Deng, Shuyu and Cong, Bingbing and Lu, Bing and Li, You},
	month = apr,
	year = {2023},
	pmid = {37028911},
	pmcid = {PMC10083867},
	note = {Place: England},
	keywords = {Humans, Prospective Studies, *Virus Diseases/diagnosis/epidemiology, *Viruses, Child, Child Care, Child Day Care Centers, Multicenter Studies as Topic, Respiratory Infection, Viral infection},
}

@article{jardim_exploratory_2023,
	title = {An {Exploratory} {Survey} on the {Care} for {Ataxic} {Patients} in the {American} {Continents} and the {Caribbean}},
	volume = {22},
	issn = {1473-4230},
	doi = {10.1007/s12311-022-01442-z},
	abstract = {Little is known about access of rare disease carriers to health care. To increase this knowledge, the Pan American Hereditary Ataxia Network (PAHAN) conducted an exploratory survey about care for hereditary ataxias in American continents and the Caribbean. A questionnaire was sent to health professionals about the hereditary ataxias identified; access to care; and local teaching and research. The number of ataxics under current care per 100,000 inhabitants was subtracted from the expected overall prevalence of 6/100,000, to estimate the prevalence of uncovered ataxic patients. Local Human Development Indexes (HDI) were used to measure socio-economic factors. Twenty-six sites participated. Twelve sites had very high, 13 had high, and one site had medium HDI. Participants reported on 2239 and 602 patients with spinocerebellar ataxias and recessive forms under current care. The number of patients under current care per inhabitants varied between 0.14 and 12/100,000. The estimated prevalence of uncovered ataxic patients was inversely proportional to HDIs (rho = 0.665, p = 0.003). Access to diagnosis, pre-symptomatic tests, and rehabilitation were associated with HDIs. More and better molecular diagnostic tools, protocols and guidelines, and professional training for ataxia care were the top priorities common to all respondents. Evidence of inequalities was confirmed. Lower HDIs were associated with high potential numbers of uncovered ataxic subjects, and with lack of molecular diagnosis, pre-symptomatic testing, and rehabilitation. More and better diagnostic tools, guidelines, and professional training were priorities to all sites. PAHAN consortium might help with the last two tasks.},
	language = {eng},
	number = {4},
	journal = {Cerebellum (London, England)},
	author = {Jardim, Laura Bannach and Hasan, Ali and Kuo, Sheng-Han and Magaña, Jonathan Javier and França, Marcondes and Marques, Wilson and Camejo, Claudia and Santana-da-Silva, Luiz Carlos and Leão, Emília Embiruçu and Espíndola, Gisele and Canals, Francisca and Miranda, Marcelo and Salvatierra, Igor and Cornejo-Olivas, Mario and Fernandez-Ruiz, Juan and Braga-Neto, Pedro and Dávila-Ortiz de Montellano, David José and Flores-Lagunes, Luis Leonardo and Dupré, Nicolas and Brais, Bernard and Vargas, Fernando Regla and Godeiro, Clécio and Coutinho, Léo and Teive, Helio G. and Kaufmann, Marcelo and Saffie, Paula and Furtado, Gabriel Vasata and Saraiva-Pereira, Maria Luiza and Barsottini, Orlando and Pedroso, José Luiz and Rodríguez-Labrada, Roberto and Velázquez-Pérez, Luis and Gomez, Christopher and {PAHAN}},
	month = aug,
	year = {2023},
	pmid = {35796998},
	keywords = {Access to health care, American continents, Ataxia, Caribbean Region, Cerebellar Ataxia, Humans, Inherited ataxias, Spinocerebellar Ataxias, Spinocerebellar Degenerations, The Caribbean},
	pages = {708--718},
}

@article{klein_impact_2022,
	title = {The impact of educational interventions on modifying health practitioners' attitudes and practice in treating people with borderline personality disorder: an integrative review},
	volume = {11},
	issn = {2046-4053},
	shorttitle = {The impact of educational interventions on modifying health practitioners' attitudes and practice in treating people with borderline personality disorder},
	doi = {10.1186/s13643-022-01960-1},
	abstract = {BACKGROUND: The rising prevalence of Borderline Personality Disorder (BPD) and suicidality represents substantial health burden worldwide. People with BPD experience high rates of crisis presentations and stigma when accessing health services. Educational interventions designed to modify health practitioners' attitudes and practice in treating people with BPD may assist in addressing this stigma. The current review aimed to identify and explore existing educational interventions designed to modify health practitioners' attitudes and practice in BPD; and determine what impact educational interventions have on improving health practitioners' responses towards people with BPD.
METHODS: A comprehensive search of the literature was undertaken in MEDLINE, CINAHL, PsycINFO, Scopus, Cochrane Library, and JBI Evidence-Based databases (from inception to February 2022). Secondary sources of literature included grey literature searches and handsearching the references of included studies as part of the comprehensive search strategy. The eligibility criteria included peer-reviewed empirical studies examining BPD-related educational interventions aimed at modifying health practitioners' attitudes and practice in treating people with BPD. Quality appraisal of the included studies were completed using the Mixed Methods Appraisal Tool 2018 version (MMAT v.18) or the Joanna Briggs Institute (JBI) Checklist for Systematic Reviews and Research Syntheses Tool. Thematic Analysis informed data extraction, analysis, interpretation, and narrative synthesis of the data.
RESULTS: A total of nine papers containing 991 participants across a diverse range of studies including, quantitative, qualitative, mixed methods, and a systematic review were included in this integrative review. Several BPD-related educational interventions designed to modify health practitioners' attitudes and practice in BPD exist. Findings suggest that training health practitioners in BPD-related educational interventions can enhance positive attitudes and change practice towards people with BPD; however, more high-quality studies are needed to confirm these conclusions.
CONCLUSIONS: This review collated and summarized findings from studies examining the impact of BPD-related educational interventions on changing health practitioners' attitudes and practice in treating this population. Results from this review may help inform future research, policy, and practice in stigma-reduction strategies which would improve the delivery of responsive health services and care for people with BPD.
SYSTEMATIC REVIEW REGISTRATION: Open Science Framework ( https://osf.io/7p6ez/ ).},
	language = {eng},
	number = {1},
	journal = {Systematic Reviews},
	author = {Klein, Pauline and Fairweather, A. Kate and Lawn, Sharon},
	month = may,
	year = {2022},
	pmid = {35637499},
	pmcid = {PMC9150362},
	keywords = {Attitude to Health, Borderline Personality Disorder, Borderline personality disorder, Community-based services, Crisis care, Education and training, Evidence-based practice, Health Knowledge, Attitudes, Practice, Health services, Healthcare system, Humans, Integrative review, Qualitative Research, Structural stigma, Suicidality, Systematic Reviews as Topic},
	pages = {108},
}

Paper  doi  abstract   bibtex   

@article{ali_proteomics_2022,
	title = {Proteomics profiling of human synovial fluid suggests increased protein interplay in early-osteoarthritis ({OA}) that is lost in late-stage {OA}},
	volume = {21},
	issn = {1535-9484},
	url = {https://doi.org/10.1016/j.mcpro.2022.100200},
	doi = {10.1016/j.mcpro.2022.100200},
	abstract = {The underlying molecular mechanisms in osteoarthritis (OA) development are largely unknown. This study explores the proteome and the pairwise interplay of proteins in synovial fluid from patients with late-stage knee OA (arthroplasty), early knee OA (arthroscopy due to degenerative meniscal tear), and from deceased controls without knee OA. Synovial fluid samples were analyzed using state-of-the-art mass spectrometry with data-independent acquisition. The differential expression of the proteins detected was clustered and evaluated with data mining strategies and a multilevel model. Group-specific slopes of associations were estimated between expressions of each pair of identified proteins to assess the co-expression (i.e., interplay) between the proteins in each group. More proteins were increased in early-OA versus controls than late-stage OA versus controls. For most of these proteins, the fold changes between late-stage OA versus controls and early-stage OA versus controls were remarkably similar suggesting potential involvement in the OA process. Further, for the first time, this study illustrated distinct patterns in protein co-expression suggesting that the interplay between the protein machinery is increased in early-OA and lost in late-stage OA. Further efforts should focus on earlier stages of the disease than previously considered.},
	language = {eng},
	number = {3},
	journal = {Molecular \& cellular proteomics: MCP},
	author = {Ali, Neserin and Turkiewicz, Aleksandra and Hughes, Velocity and Folkesson, Elin and Tjörnstand, Jon and Neuman, Paul and Önnerfjord, Patrik and Englund, Martin},
	month = mar,
	year = {2022},
	pmid = {35074580},
	pmcid = {PMC8941261},
	note = {Number: 3},
	keywords = {DIA, Humans, Mass Spectrometry, Osteoarthritis, Knee, Proteome, Proteomics, Synovial Fluid, early- and late-stage OA, osteoarthritis, proteomics, synovial fluid},
	pages = {100200},
}

@article{li_risk_2021,
	title = {Risk factors for poor outcomes in hospitalised {COVID}-19 patients: {A} systematic review and meta-analysis},
	volume = {11},
	issn = {2047-2986},
	shorttitle = {Risk factors for poor outcomes in hospitalised {COVID}-19 patients},
	doi = {10.7189/jogh.11.10001},
	abstract = {Background: Understanding the risk factors for poor outcomes among COVID-19 patients could help identify vulnerable populations who would need prioritisation in prevention and treatment for COVID-19. We aimed to critically appraise and synthesise published evidence on the risk factors for poor outcomes in hospitalised COVID-19 patients.
Methods: We searched PubMed, medRxiv and the WHO COVID-19 literature database for studies that reported characteristics of COVID-19 patients who required hospitalisation. We included studies published between January and May 2020 that reported adjusted effect size of any demographic and/or clinical factors for any of the three poor outcomes: mortality, intensive care unit (ICU) admission, and invasive mechanical ventilation. We appraised the quality of the included studies using Joanna Briggs Institute appraisal tools and quantitatively synthesised the evidence through a series of random-effect meta-analyses. To aid data interpretation, we further developed an interpretation framework that indicated strength of the evidence, informed by both quantity and quality of the evidence.
Results: We included a total of 40 studies in our review. Most of the included studies (29/40, 73\%) were assessed as "good quality", with assessment scores of 80 or more. We found that male sex (pooled odds ratio (OR) = 1.32 (95\% confidence interval (CI) = 1.18-1.48; 20 studies), older age (OR = 1.05, 95\% CI = 1.04-1.07, per one year of age increase; 10 studies), obesity (OR = 1.59, 95\% CI = 1.02-2.48; 4 studies), diabetes (OR = 1.25, 95\% CI = 1.11-1.40; 11 studies) and chronic kidney diseases (6 studies; OR = 1.57, 95\% CI = 1.27-1.93) were associated with increased risks for mortality with the greatest strength of evidence based on our interpretation framework. We did not find increased risk of mortality for several factors including chronic obstructive pulmonary diseases (5 studies), cancer (4 studies), or current smoker (5 studies); however, this does not indicate absence of risk due to limited data on each of these factors.
Conclusion: Male sex, older age, obesity, diabetes and chronic kidney diseases are important risk factors of COVID-19 poor outcomes. Our review provides not only an appraisal and synthesis of evidence on the risk factors of COVID-19 poor outcomes, but also a data interpretation framework that could be adopted by relevant future research.},
	language = {eng},
	journal = {Journal of Global Health},
	author = {Li, You and Ashcroft, Thulani and Chung, Alexandria and Dighero, Izzie and Dozier, Marshall and Horne, Margaret and McSwiggan, Emilie and Shamsuddin, Azwa and Nair, Harish},
	month = mar,
	year = {2021},
	pmid = {33767855},
	pmcid = {PMC7980087},
	keywords = {Aged, COVID-19, Comorbidity, Female, Hospitalization, Humans, Intensive Care Units, Male, Respiration, Artificial, Risk Factors, SARS-CoV-2, Severity of Illness Index},
	pages = {10001},
}

@article{hildebrandt_randomized_2020,
	title = {Randomized {Controlled} {Trial} {Comparing} {Health} {Coach}-{Delivered} {Smartphone}-{Guided} {Self}-{Help} {With} {Standard} {Care} for {Adults} {With} {Binge} {Eating}.},
	volume = {177},
	issn = {1535-7228 0002-953X},
	doi = {10/ghsrqp},
	abstract = {OBJECTIVE: Cognitive-behavioral therapy (CBT) has shown efficacy in the treatment of eating disorders. The authors conducted a randomized controlled telemedicine trial  of CBT-guided self-help (CBT-GSH) assisted with a smartphone app, Noom Monitor, for  binge eating with or without purging. They hypothesized that coach-delivered CBT-GSH  telemedicine sessions plus Noom Monitor would yield greater reductions in symptoms  of binge eating, purging, and eating disorders compared with standard care. METHODS:  Fifty-two-week outcomes for CBT-GSH plus Noom Monitor (N=114) were compared with  outcomes for standard care (N=111) among members of an integrated health care system  in the Pacific Northwest. Patients in the health system who met inclusion criteria  were ≥18 years old, had a body mass index ≥18.5, met criteria for DSM-5 binge eating  disorder or bulimia nervosa, had 12 months of continuous health care enrollment in  Kaiser Permanente Northwest, and had a personal smartphone. Participants received  eight CBT-GSH telemedicine sessions over 12 weeks administered by health coaches,  and outcomes were assessed at baseline and at weeks 4, 8, 12, 26, and 52. The use of  available treatment offered within the Kaiser Permanente health care system was  permitted for participants assigned to standard care. RESULTS: Participants who  received CBT-GSH plus Noom Monitor reported significant reductions in objective  binge-eating days (β=-0.66, 95\% CI=-1.06, -0.25; Cohen's d=-1.46, 95\% CI=-4.63,  -1.09) and achieved higher rates of remission (56.7\% compared with 30\%; number  needed to treat=3.74) at 52 weeks compared with participants in standard care, none  of whom received any eating disorder treatment during the intervention period  (baseline and weeks 1-12). Similar patterns emerged for compensatory behaviors  (vomiting, use of laxatives, and excessive exercise; 76.3\% compared with 56.8\%;  number needed to treat=5.11), eating disorder symptoms (body shape, weight, eating  concerns, and dietary restraint), and clinical impairment (Cohen's d=-10.07, -2.15).  CONCLUSIONS: These results suggest that CBT-GSH plus Noom Monitor delivered via  telemedicine by routine-practice health coaches in a nonacademic health care system  yields reductions in symptoms and impairment over 52 weeks compared with standard  care.},
	language = {eng},
	number = {2},
	journal = {The American journal of psychiatry},
	author = {Hildebrandt, Tom and Michaeledes, Andreas and Mayhew, Meghan and Greif, Rebecca and Sysko, Robyn and Toro-Ramos, Tatiana and DeBar, Lynn},
	month = feb,
	year = {2020},
	pmid = {32008396},
	note = {Place: United States},
	keywords = {*Cognitive, *Cognitive Behavioral Therapy, *Computers, *Eating Disorders, *Gender Differences, *Metabolism, *Obsessive-Compulsive Disorder, *Smartphone, Adolescent, Adult, Binge-Eating Disorder/*therapy, Female, Humans, Male, Mentoring, Middle Aged, Telemedicine/*methods, Young Adult},
	pages = {134--142},
}

Website  abstract   bibtex   

@article{
 title = {Intrinsic functional and structural connectivity of emotion regulation networks in obsessive-compulsive disorder},
 type = {article},
 year = {2019},
 identifiers = {[object Object]},
 keywords = {Adult,Amygdala,Case-Control Studies,Emotions,Female,Humans,Magnetic Resonance Imaging,Male,Obsessive-Compulsive Disorder},
 pages = {110-120},
 volume = {36},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/30253000},
 id = {da7dfdeb-3ba9-322b-bbdc-f9d9b860019d},
 created = {2020-09-17T09:27:48.121Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:48.121Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {Despite emotion regulation being altered in patients with obsessive-compulsive disorder (OCD), no studies have investigated its relation to multimodal amygdala connectivity. We compared corticolimbic functional and structural connectivity between OCD patients and healthy controls (HCs), and correlated this with the dispositional use of emotion regulation strategies and with OCD severity. OCD patients (n = 73) and HCs (n = 42) were assessed for suppression and reappraisal strategies using the Emotion Regulation Questionnaire (ERQ) and for OCD severity using the Yale-Brown Obsessive-Compulsive Scale. Resting-state functional magnetic resonance imaging (rs-fMRI) connectivity maps were generated using subject-specific left amygdala (LA) and right amygdala (RA) masks. We identified between-group differences in amygdala whole-brain connectivity, and evaluated the moderating effect of ERQ strategies. Significant regions and amygdala seeds were used as targets in probabilistic tractography analysis. Patients scored higher in suppression and lower in reappraisal. We observed higher rs-fMRI RA-right postcentral gyrus (PCG) connectivity in HC, and in patients this was correlated with symptom severity. Reappraisal scores were associated with higher negative LA-left insula connectivity in HC, and suppression scores were negatively associated with LA-precuneus and angular gyri connectivity in OCD. Structurally, patients showed higher mean diffusivity in tracts connecting the amygdala with the other targets. RA-PCG connectivity is diminished in patients, while disrupted emotion regulation is related to altered amygdala connectivity with the insula and posterior brain regions. Our results are the first showing, from a multimodal perspective, the association between amygdala connectivity and specific emotional processing domains, emphasizing the importance of amygdala connectivity in OCD pathophysiology.},
 bibtype = {article},
 author = {Picó-Pérez, Maria and Ipser, Jonathan and Taylor, Paul and Alonso, Pino and López-Solà, Clara and Real, Eva and Segalàs, Cinto and Roos, Annerine and Menchón, José M and Stein, Dan J and Soriano-Mas, Carles},
 journal = {Depression and Anxiety},
 number = {2}
}

@article{jones_mobile_2018,
	title = {Mobile {Healthcare} and {People} with {Disabilities}: {Current} {State} and {Future} {Needs}},
	volume = {15},
	issn = {1660-4601},
	shorttitle = {Mobile {Healthcare} and {People} with {Disabilities}},
	doi = {10.3390/ijerph15030515},
	abstract = {Significant health disparities exist between the general population and people with disabilities, particularly with respect to chronic health conditions. Mobile healthcare-the delivery of healthcare via mobile communication devices-is witnessing tremendous growth and has been touted as an important new approach for management of chronic health conditions. At present, little is known about the current state of mobile healthcare for people with disabilities. Early evidence suggests they are not well represented in the growth of mobile healthcare, and particularly the proliferation of mobile health software applications (mHealth apps) for smartphones. Their omission in mHealth could lead to further health disparities. This article describes our research investigating the current state of mHealth apps targeting people with disabilities. Based on a multi-modal approach (literature review, Internet search, survey of disabled smartphone users), we confirm that people with disabilities are under-represented in the growth of mHealth. We identify several areas of future research and development needed to support the inclusion of people with disabilities in the mHealth revolution.},
	language = {eng},
	number = {3},
	journal = {International Journal of Environmental Research and Public Health},
	author = {Jones, Michael and Morris, John and Deruyter, Frank},
	year = {2018},
	pmid = {29538292},
	pmcid = {PMC5877060},
	note = {Number: 3},
	keywords = {Chronic Disease, Disabled Persons, Healthcare Disparities, Humans, Internet, Mobile Applications, Smartphone, Telemedicine, United States, chronic health conditions, information and communication technologies, mHealth, mobile healthcare, people with disabilities, software applications for smart phones},
}

@article {650292,
	title = {Ovarian Cancer: Prevalence in Incidental Simple Adnexal Cysts Initially Identified in CT Examinations of the Abdomen and Pelvis},
	journal = {Radiology},
	volume = {286},
	number = {1},
	year = {2018},
	month = {2018 01},
	pages = {196-204},
	abstract = {Purpose To evaluate the rate of malignancy in incidentally detected simple adnexal cysts at computed tomography (CT) to determine if simple-appearing cysts require follow-up. Materials and Methods In this HIPAA-compliant, institutional review board-approved retrospective cohort study, an institutional database was searched for abdominal and pelvic CT studies performed between June 2003 and December 2010 in women reported to have adnexal cysts. Adnexal cyst characterization was determined by prospective report description as well as image review by a research fellow and by a fellowship-trained abdominal radiologist for examinations with disagreement between the original report and the research fellow{\textquoteright}s assessment. Patients with known ovarian cysts or ovarian cancer at time of the index CT examination were excluded. Clinical outcome was assessed by using follow-up imaging studies, medical records, and the state cancer registry. Benign outcome was determined by benign findings at surgery, a decrease in size or resolution of a simple-appearing cyst at follow-up imaging, or stability of the cyst for at least 1 year. Descriptive statistics and 95\% confidence intervals (CIs) were calculated. Results Among 42 111 women who underwent abdominal and pelvic CT examinations in the study period, 2763 (6.6\%; 95\% CI: 6.3\%, 6.8\%) (mean age, 48.1 years {\textpm} 18.1; range, 15-102 years) had a newly detected finding of ovarian cyst described in the body or impression section of the report. Median cyst size was 3.1 cm (range, 0.8-20.0 cm). Eighteen (0.7\%; 95\% CI: 0.4\%, 1.0\%) of 2763 patients were found to have ovarian cancer after an average follow-up of 5.1 years {\textpm} 3.8 (range, 0-12.8 years). None (95\% CI: 0\%, 0.4\%) of 1031 women with simple-appearing cysts were given a diagnosis of ovarian cancer. This included none (95\% CI: 0\%, 0.4\%) of 904 women with simple-appearing cysts with an adequate reference standard for benign outcome. Conclusion The prevalence of previously unknown adnexal cysts at CT was 6.6\%, with an ovarian cancer rate of 0.7\% (95\% CI: 0.4\%, 1.0\%). All simple-appearing cysts were benign (95\% CI: 99.6\%, 100\%).  RSNA, 2017 Online supplemental material is available for this article.},
	keywords = {Abdomen, Adult, Aged, Female, Humans, Incidental Findings, Middle Aged, Ovarian Cysts, Ovarian Neoplasms, Pelvis, Retrospective Studies, Tomography, X-Ray Computed},
	issn = {1527-1315},
	doi = {10.1148/radiol.2017162139},
	author = {Johannes Boos and Olga R Brook and Jieming Fang and Alexander Brook and Levine, Deborah}
}

@article{albers_estimating_2018,
	title = {Estimating summary statistics for electronic health record laboratory data for use in high-throughput phenotyping algorithms},
	volume = {78},
	issn = {1532-0480},
	doi = {10.1016/j.jbi.2018.01.004},
	abstract = {We study the question of how to represent or summarize raw laboratory data taken from an electronic health record (EHR) using parametric model selection to reduce or cope with biases induced through clinical care. It has been previously demonstrated that the health care process (Hripcsak and Albers, 2012, 2013), as defined by measurement context (Hripcsak and Albers, 2013; Albers et al., 2012) and measurement patterns (Albers and Hripcsak, 2010, 2012), can influence how EHR data are distributed statistically (Kohane and Weber, 2013; Pivovarov et al., 2014). We construct an algorithm, PopKLD, which is based on information criterion model selection (Burnham and Anderson, 2002; Claeskens and Hjort, 2008), is intended to reduce and cope with health care process biases and to produce an intuitively understandable continuous summary. The PopKLD algorithm can be automated and is designed to be applicable in high-throughput settings; for example, the output of the PopKLD algorithm can be used as input for phenotyping algorithms. Moreover, we develop the PopKLD-CAT algorithm that transforms the continuous PopKLD summary into a categorical summary useful for applications that require categorical data such as topic modeling. We evaluate our methodology in two ways. First, we apply the method to laboratory data collected in two different health care contexts, primary versus intensive care. We show that the PopKLD preserves known physiologic features in the data that are lost when summarizing the data using more common laboratory data summaries such as mean and standard deviation. Second, for three disease-laboratory measurement pairs, we perform a phenotyping task: we use the PopKLD and PopKLD-CAT algorithms to define high and low values of the laboratory variable that are used for defining a disease state. We then compare the relationship between the PopKLD-CAT summary disease predictions and the same predictions using empirically estimated mean and standard deviation to a gold standard generated by clinical review of patient records. We find that the PopKLD laboratory data summary is substantially better at predicting disease state. The PopKLD or PopKLD-CAT algorithms are not meant to be used as phenotyping algorithms, but we use the phenotyping task to show what information can be gained when using a more informative laboratory data summary. In the process of evaluation our method we show that the different clinical contexts and laboratory measurements necessitate different statistical summaries. Similarly, leveraging the principle of maximum entropy we argue that while some laboratory data only have sufficient information to estimate a mean and standard deviation, other laboratory data captured in an EHR contain substantially more information than can be captured in higher-parameter models.},
	language = {eng},
	journal = {Journal of Biomedical Informatics},
	author = {Albers, D. J. and Elhadad, N. and Claassen, J. and Perotte, R. and Goldstein, A. and Hripcsak, G.},
	year = {2018},
	pmid = {29369797},
	pmcid = {PMC5856130},
	keywords = {Algorithms, Clinical Laboratory Techniques, Data Mining, Electronic Health Records, Electronic health record, High-Throughput Screening Assays, Humans, Kullback-Leibler divergence, Laboratory tests, Models, Statistical, Phenotype, Summary statistic, phenotyping},
	pages = {87--101},
}

@article{lally_remission_2017-1,
	title = {Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies},
	volume = {211},
	issn = {1472-1465},
	shorttitle = {Remission and recovery from first-episode psychosis in adults},
	doi = {10.1192/bjp.bp.117.201475},
	abstract = {BackgroundRemission and recovery rates for people with first-episode psychosis (FEP) remain uncertain.AimsTo assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators.MethodWe conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies with more than 1 year of follow-up data, and conducted meta-regression analyses to investigate potential moderators.ResultsSeventy-nine studies were included representing 19072 patients with FEP. The pooled rate of remission among 12301 individuals with FEP was 58\% (60 studies, mean follow-up 5.5 years). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 38\% (35 studies, mean follow-up 7.2 years). Recovery rates were higher in North America than in other regions.ConclusionsRemission and recovery rates in FEP may be more favourable than previously thought. We observed stability of recovery rates after the first 2 years, suggesting that a progressive deteriorating course of illness is not typical. Although remission rates have improved over time recovery rates have not, raising questions about the effectiveness of services in achieving improved recovery.},
	language = {eng},
	number = {6},
	journal = {The British Journal of Psychiatry: The Journal of Mental Science},
	author = {Lally, John and Ajnakina, Olesya and Stubbs, Brendon and Cullinane, Michael and Murphy, Kieran C. and Gaughran, Fiona and Murray, Robin M.},
	month = dec,
	year = {2017},
	pmid = {28982659},
	keywords = {Adult, Humans, Outcome Assessment (Health Care), Psychotic Disorders},
	pages = {350--358}
}

@article{lee_deep_2017,
	title = {Deep {Learning} in {Medical} {Imaging}: {General} {Overview}.},
	volume = {18},
	issn = {2005-8330 1229-6929},
	doi = {10.3348/kjr.2017.18.4.570},
	abstract = {The artificial neural network (ANN)-a machine learning technique inspired by the human neuronal synapse system-was introduced in the 1950s. However, the ANN was  previously limited in its ability to solve actual problems, due to the vanishing  gradient and overfitting problems with training of deep architecture, lack of  computing power, and primarily the absence of sufficient data to train the  computer system. Interest in this concept has lately resurfaced, due to the  availability of big data, enhanced computing power with the current graphics  processing units, and novel algorithms to train the deep neural network. Recent  studies on this technology suggest its potentially to perform better than humans  in some visual and auditory recognition tasks, which may portend its applications  in medicine and healthcare, especially in medical imaging, in the foreseeable  future. This review article offers perspectives on the history, development, and  applications of deep learning technology, particularly regarding its applications  in medical imaging.},
	language = {eng},
	number = {4},
	journal = {Korean journal of radiology},
	author = {Lee, June-Goo and Jun, Sanghoon and Cho, Young-Won and Lee, Hyunna and Kim, Guk Bae and Seo, Joon Beom and Kim, Namkug},
	month = aug,
	year = {2017},
	pmid = {28670152},
	pmcid = {PMC5447633},
	note = {Place: Korea (South)},
	keywords = {*Algorithms, *Neural Networks, Computer, Artificial intelligence, Computer-aided, Convolutional neural network, Humans, Image Processing, Computer-Assisted, Knee/diagnostic imaging, Machine learning, Magnetic Resonance Imaging, Optical Imaging/methods, Precision medicine, Radiology, Recurrent Neural Network},
	pages = {570--584},
}

@article{de_souza_etiopathogenesis_2017,
	title = {Etiopathogenesis of inflammatory bowel disease: today and tomorrow},
	volume = {33},
	issn = {1531-7056},
	shorttitle = {Etiopathogenesis of inflammatory bowel disease},
	doi = {10.1097/MOG.0000000000000364},
	abstract = {PURPOSE OF REVIEW: Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), represent chronic diseases of unknown cause, and they are regarded as prototypical complex diseases. Despite all the recent advances, a complete appreciation of the pathogenesis of IBD is still limited. In this review, we present recent information contributing to a better understanding of mechanisms underlying IBD.
RECENT FINDINGS: Here, we attempt to highlight novel environmental triggers, data on the gut microbiota, its interaction with the host, and the potential influence of diet and food components. We discuss recent findings on defective signaling pathways and the potential effects on the immune response, and we present new data on epigenetic changes, inflammasome, and damage-associated molecular patterns associated with IBD.
SUMMARY: The continuing identification of several epigenetic, transcriptomic, proteomic, and metabolomic alterations in patients with IBD reflects the complex nature of the disease and suggests the need for innovative approaches such as systems biology for identifying novel relevant targets in IBD.},
	language = {eng},
	number = {4},
	journal = {Current Opinion in Gastroenterology},
	author = {de Souza, Heitor S. P.},
	month = jul,
	year = {2017},
	pmid = {28402995},
	keywords = {Diet, Western, Epigenomics, Gastrointestinal Microbiome, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Immunity, Innate, Inflammatory Bowel Diseases, Metabolomics, Proteomics, Risk Factors, Systems Biology},
	pages = {222--229},
}

@article{dainton_protocol_2016,
	title = {A {Protocol} to {Develop} {Practice} {Guidelines} for {Primary} {Care} {Medical} {Service} {Trips}},
	volume = {82},
	issn = {2214-9996},
	doi = {10.1016/j.aogh.2016.10.001},
	abstract = {BACKGROUND: North American clinicians are increasingly participating in medical service trips (MSTs) that provide primary healthcare in Latin America and the Caribbean. Literature reviews have shown that the existence and use of evidence-based guidelines by these groups are limited, which presents potential for harm.
OBJECTIVE: This paper proposes a 5-step methodology to develop protocols for diagnosis and treatment of conditions encountered by MST clinicians.
METHODS: We reviewed the 2010 American College of Physicians guidance statement on guidelines development and developed our own adaptation. Ancestry search of the American College of Physicians statement identified specific publications that provided additional detail on key steps in the guideline development process, with additional focus given to evidence, equity, and local adaptation considerations.
FINDINGS: Our adaptation produced a 5-step process for developing locally optimized protocols for diagnosis and treatment of common conditions seen in MSTs. For specified conditions, this process includes: 1) a focused environmental scan of current practices based on grey literature protocols from MST sending organizations; 2) a review of relevant practice guidelines; 3) a literature review assessing the epidemiology, diagnosis, and treatment of the specified condition; 4) an eDelphi process with experts representing MST and Latin American and the Caribbean partner organizations assessing identified guidelines; and 5) external peer review and summary.
CONCLUSIONS: This protocol will enable the creation of practice guidelines that are based on best available evidence, local knowledge, and equitable considerations. The development of guidelines using this process could optimize the conduct of MSTs, while prioritizing input from local community partners.},
	language = {eng},
	number = {5},
	journal = {Annals of Global Health},
	author = {Dainton, Christopher and Chu, Charlene H. and Lin, Henry and Cherniak, William and Loh, Lawrence C.},
	month = oct,
	year = {2016},
	pmid = {28283118},
	keywords = {Caribbean Region, Delivery of Health Care, Ethnicity, Health Knowledge, Attitudes, Practice, Health Services, Humans, International Cooperation, Latin America, Medical Missions, North America, Practice Guidelines as Topic, Primary Health Care, global health, humanitarian health, international health, medical missions, medical service trips},
	pages = {678--685},
}

@article{coullin_involvement_2015,
	title = {The involvement of the trans-generational effect in the high incidence of the hydatidiform mole in {Africa}},
	volume = {36},
	issn = {1532-3102},
	doi = {10.1016/j.placenta.2014.10.017},
	abstract = {INTRODUCTION: While the incidence of various chromosomal anomalies observed, including triploid partial moles is independent of the socio-economic level, higher incidences of complete hydatidiform mole "CHM" is generally associated with under developed areas. Moreover, studies have shown that some nutritional deficiencies are related to the abnormal development of oocytes and placenta. In Senegal and Morocco, the annual seasonal cycle contains one period with food shortages and the incidence of complete moles is significant. Accordingly, accurate statistical analyses have been performed in these two countries.
METHODS: Each month during a one year period, we investigated the occurrence of normal conceptions, molar conceptions and the conception of the future patients in Senegal and Morocco. The comparisons of the conception dates for these three types of conception were analyzed using the Chi-squared test.
RESULTS: 94\% of the patients were conceived just prior to the period in the year with food shortages. Consequently, the development of the female embryos occurred under nutritional constraints, which negatively affect the recruitment of the vital factors required for the normal synthesis of DNA, proteins and placental differentiation.
DISCUSSIONS: A nutritional deficiency in the mother at conception of their daughter (future patient) is implicated in the higher incidence of CHM in their daughters' filiation. These nutritional deficiencies during the first weeks of pregnancy will have repercussions on the normal development of the oocytes. Accordingly, these developmental impairments take place during the embryonic life of the future mothers of complete moles and not during the conception of the moles themselves.},
	language = {eng},
	number = {1},
	journal = {Placenta},
	author = {Coullin, P. and Diatta, A. L. and Boufettal, H. and Feingold, J. and Leguern, E. and Candelier, J. J.},
	month = jan,
	year = {2015},
	pmid = {25468544},
	keywords = {Female, Humans, Hydatidiform Mole, Incidence, Maternal Nutritional Physiological Phenomena, Morocco, Nutrition, Nutritional Status, Oocyte, Placental development, Pregnancy, Senegal, Uterine Neoplasms, trophoblast},
	pages = {48--51},
}

@article{silverberg_cumulative_2015,
	title = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}: {A} {Cohort} {Study}},
	volume = {163},
	issn = {1539-3704},
	shorttitle = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}},
	doi = {10.7326/M14-2768},
	abstract = {BACKGROUND: Cancer is increasingly common among persons with HIV.
OBJECTIVE: To examine calendar trends in cumulative cancer incidence and hazard rate by HIV status.
DESIGN: Cohort study.
SETTING: North American AIDS Cohort Collaboration on Research and Design during 1996 to 2009.
PARTICIPANTS: 86 620 persons with HIV and 196 987 uninfected adults.
MEASUREMENTS: Cancer type-specific cumulative incidence by age 75 years and calendar trends in cumulative incidence and hazard rates, each by HIV status.
RESULTS: Cumulative incidences of cancer by age 75 years for persons with and without HIV, respectively, were as follows: Kaposi sarcoma, 4.4\% and 0.01\%; non-Hodgkin lymphoma, 4.5\% and 0.7\%; lung cancer, 3.4\% and 2.8\%; anal cancer, 1.5\% and 0.05\%; colorectal cancer, 1.0\% and 1.5\%; liver cancer, 1.1\% and 0.4\%; Hodgkin lymphoma, 0.9\% and 0.09\%; melanoma, 0.5\% and 0.6\%; and oral cavity/pharyngeal cancer, 0.8\% and 0.8\%. Among persons with HIV, calendar trends in cumulative incidence and hazard rate decreased for Kaposi sarcoma and non-Hodgkin lymphoma. For anal, colorectal, and liver cancer, increasing cumulative incidence, but not hazard rate trends, were due to the decreasing mortality rate trend (-9\% per year), allowing greater opportunity to be diagnosed. Despite decreasing hazard rate trends for lung cancer, Hodgkin lymphoma, and melanoma, cumulative incidence trends were not seen because of the compensating effect of the declining mortality rate.
LIMITATION: Secular trends in screening, smoking, and viral co-infections were not evaluated.
CONCLUSION: Cumulative cancer incidence by age 75 years, approximating lifetime risk in persons with HIV, may have clinical utility in this population. The high cumulative incidences by age 75 years for Kaposi sarcoma, non-Hodgkin lymphoma, and lung cancer support early and sustained antiretroviral therapy and smoking cessation.},
	language = {eng},
	number = {7},
	journal = {Annals of Internal Medicine},
	author = {Silverberg, Michael J. and Lau, Bryan and Achenbach, Chad J. and Jing, Yuezhou and Althoff, Keri N. and D'Souza, Gypsyamber and Engels, Eric A. and Hessol, Nancy A. and Brooks, John T. and Burchell, Ann N. and Gill, M. John and Goedert, James J. and Hogg, Robert and Horberg, Michael A. and Kirk, Gregory D. and Kitahata, Mari M. and Korthuis, Philip T. and Mathews, William C. and Mayor, Angel and Modur, Sharada P. and Napravnik, Sonia and Novak, Richard M. and Patel, Pragna and Rachlis, Anita R. and Sterling, Timothy R. and Willig, James H. and Justice, Amy C. and Moore, Richard D. and Dubrow, Robert and {North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS}},
	month = oct,
	year = {2015},
	pmid = {26436616},
	pmcid = {PMC4711936},
	keywords = {Adult, Age Distribution, Aged, Anus Neoplasms, Cohort Studies, Colorectal Neoplasms, Comorbidity, Female, HIV Infections, Humans, Incidence, Liver Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Male, Middle Aged, Neoplasms, North America, Proportional Hazards Models, Sarcoma, Kaposi},
	pages = {507--518},
}

@article{torossian_cxcr7_2014,
	title = {{CXCR7} participates in {CXCL12}-induced {CD34}+ cell cycling through β-arrestin-dependent {Akt} activation},
	volume = {123},
	issn = {1528-0020},
	doi = {10.1182/blood-2013-05-500496},
	abstract = {In addition to its well-known effect on migration and homing of hematopoietic stem/progenitor cells (HSPCs), CXCL12 chemokine also exhibits a cell cycle and survival-promoting factor for human CD34(+) HSPCs. CXCR4 was suggested to be responsible for CXCL12-induced biological effects until the recent discovery of its second receptor, CXCR7. Until now, the participation of CXCR7 in CXCL12-induced HSPC cycling and survival is unknown. We show here that CXCL12 was capable of binding CXCR7 despite its scarce expression at CD34(+) cell surface. Blocking CXCR7 inhibited CXCL12-induced Akt activation as well as the percentage of CD34(+) cells in cycle, colony formation, and survival, demonstrating its participation in CXCL12-induced functional effects in HSPCs. At steady state, CXCR7 and β-arrestin2 co-localized near the plasma membrane of CD34(+) cells. After CXCL12 treatment, β-arrestin2 translocated to the nucleus, and this required both CXCR7 and CXCR4. Silencing β-arrestin expression decreased CXCL12-induced Akt activation in CD34(+) cells. Our results demonstrate for the first time the role of CXCR7, complementary to that played by CXCR4, in the control of HSPC cycling, survival, and colony formation induced by CXCL12. We also provide evidence for the involvement of β-arrestins as signaling hubs downstream of both CXCL12 receptors in primary human HSPCs.},
	language = {eng},
	number = {2},
	journal = {Blood},
	author = {Torossian, Frédéric and Anginot, Adrienne and Chabanon, Aurélie and Clay, Denis and Guerton, Bernadette and Desterke, Christophe and Boutin, Laetitia and Marullo, Stefano and Scott, Mark G H and Lataillade, Jean-Jacques and Le Bousse-Kerdilès, Marie-Caroline},
	month = jan,
	year = {2014},
	keywords = {Antigens, CD34, Arrestins, Cell Cycle, Cell Survival, Chemokine CXCL12, Colony-Forming Units Assay, Enzyme Activation, Hematopoietic Stem Cells, Humans, Intracellular Space, Phosphorylation, Protein Binding, Protein Transport, Proto-Oncogene Proteins c-akt, Receptors, CXCR},
	pages = {191--202},
}

@article{tse_cruciferous_2014,
	title = {Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis},
	volume = {66},
	issn = {1532-7914},
	shorttitle = {Cruciferous vegetables and risk of colorectal neoplasms},
	doi = {10.1080/01635581.2014.852686},
	abstract = {Evidence shows cruciferous vegetables exhibit chemoprotective properties, commonly attributed to their rich source of isothiocyanates. However, epidemiological data examining the association between cruciferous vegetable intake and colorectal neoplasms have been inconclusive. This meta-analysis examines the epidemiological evidence to characterize the association between cruciferous vegetable intake and risk of developing colorectal neoplasms. Thirty-three articles were included in the meta-analysis after a literature search of electronic databases. Subgroup analysis for individual cruciferae types (n = 8 studies) and GST polymorphism (n = 8 studies) were performed. Pooled adjusted odds ratios (ORs) comparing highest and lowest categories of dietary pattern scores were calculated. Results show a statistically significant inverse association between cruciferous vegetable intake and colon cancer [OR = 0.84; 95\% confidence interval (CI): 0.72-0.98; P value heterogeneity {\textless} 0.001]. Broccoli in particular exhibited protective benefits against colorectal (CRC) neoplasms (OR = 0.80; 95\% CI: 0.65-0.99; P value heterogeneity = 0.02). Stratification by GST genotype reveals that the GSTT1 null genotype confers a reduction in CRC risk (OR = 0.78; 95\% CI: 0.64-0.95; P value heterogeneity = 0.32). This study provides support to the hypothesis that cruciferous vegetable intake protects against cancer of the colon. This study also demonstrates the significance of gene-diet interactions and the importance of assessing individual cruciferous vegetables.},
	language = {eng},
	number = {1},
	journal = {Nutrition and Cancer},
	author = {Tse, Genevieve and Eslick, Guy D.},
	year = {2014},
	pmid = {24341734},
	keywords = {Animals, Brassica, Brassicaceae, Colorectal Neoplasms, Disease Models, Animal, Feeding Behavior, Gene-Environment Interaction, Genotype, Glutathione Transferase, Humans, Observational Studies as Topic, Polymorphism, Genetic, Risk Factors, Vegetables},
	pages = {128--139},
}

Paper  doi  abstract   bibtex   

@article{Heiker-2014-ID6,
  title     = {Identification of genetic loci associated with different responses to
               high-fat diet-induced obesity in C57{BL}/6N and C57{BL}/6J substrains.},
  abstract  = {We have recently demonstrated that C57{BL}/6{NT}ac and C57{BL}/6{JR}j
               substrains are significantly different in their response to high-fat
               diet-induced obesity ({DIO}). The C57{BL}/6{JR}j substrain seems to be
               protected from {DIO} and genetic differences between C57{BL}/6J and
               C57{BL}/6N substrains at 11 single nucleotide polymorphism ({SNP}) loci
               have been identified. To define genetic variants as well as differences in
               parameters of glucose homeostasis and insulin sensitivity between
               C57{BL}/6{NT}ac and C57{BL}/6{JR}j substrains that may explain the
               different response to {DIO}, we analyzed 208 first backcross ({BC}1)
               hybrids of C57{BL}/6{NT}ac and C57{BL}/6{JR}j [(C57{BL}/6{NT}ac ×
               C57{BL}/6{JR}j)F1 × C57{BL}/6{NT}ac] mice. Body weight, epigonadal and
               subcutaneous fat mass, circulating leptin, as well as parameters of glucose
               metabolism were measured after 10 wk of high-fat diet ({HFD}). Genetic
               profiling of {BC}1 hybrids were performed using TaqMan {SNP} genotyping
               assays. Furthermore, to assess whether {SNP} polymorphisms could affect
               m{RNA} level, we carried out gene expression analysis in murine liver
               samples. Human subcutaneous adipose tissue was used to verify murine data
               of {SNAP}29. We identified four sex-specific variants that are associated
               with the extent of {HFD}-induced weight gain and fat depot mass. {BC}1
               hybrids carrying the combination of risk or beneficial alleles exhibit the
               phenotypical extremes of the parental strains. Murine and human {SC}
               expression analysis revealed Snap29 as strongest candidate. Our data
               indicate an important role of these loci in responsiveness to {HFD}-induced
               obesity and suggest genes of the synaptic vesicle release system such as
               Snap29 being involved in the regulation of high-fat {DIO}.},
  author    = {Heiker, John T and Kunath, Anne and Kosacka, Joanna and Flehmig, Gesine and
               Knigge, Anja and Kern, Matthias and Stumvoll, Michael and Kovacs, Peter and
               Blüher, Matthias and Klöting, Nora},
  volume    = {46},
  number    = {11},
  pages     = {377--84},
  year      = {2014},
  month     = {6},
  url       = {http://www.pubmed.org/24692188},
  pmid      = {24692188},
  doi       = {10.1152/physiolgenomics.00014.2014},
  keywords  = {Animals, Humans, Mice, Male, Adipose Tissue, Alleles, Body Weight, Diet,
               High-Fat, Female, Genetic Loci, Genotype, Glucose, Leptin, Mice, Inbred
               C57{BL}, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Vesicular
               Transport Proteins, Weight Gain},
  file      = {FULLTEXT:pdfs/000/000/000000006.pdf:PDF}
}

@article{hippisley-cox_performance_2014,
	title = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice: a validation study},
	volume = {4},
	issn = {2044-6055},
	shorttitle = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice},
	doi = {10.1136/bmjopen-2014-005809},
	abstract = {OBJECTIVES: To validate the performance of a set of risk prediction algorithms developed using the QResearch database, in an independent sample from general practices contributing to the Clinical Research Data Link (CPRD).
SETTING: Prospective open cohort study using practices contributing to the CPRD database and practices contributing to the QResearch database.
PARTICIPANTS: The CPRD validation cohort consisted of 3.3 million patients, aged 25-99 years registered at 357 general practices between 1 Jan 1998 and 31 July 2012. The validation statistics for QResearch were obtained from the original published papers which used a one-third sample of practices separate to those used to derive the score. A cohort from QResearch was used to compare incidence rates and baseline characteristics and consisted of 6.8 million patients from 753 practices registered between 1 Jan 1998 and until 31 July 2013.
OUTCOME MEASURES: Incident events relating to seven different risk prediction scores: QRISK2 (cardiovascular disease); QStroke (ischaemic stroke); QDiabetes (type 2 diabetes); QFracture (osteoporotic fracture and hip fracture); QKidney (moderate and severe kidney failure); QThrombosis (venous thromboembolism); QBleed (intracranial bleed and upper gastrointestinal haemorrhage). Measures of discrimination and calibration were calculated.
RESULTS: Overall, the baseline characteristics of the CPRD and QResearch cohorts were similar though QResearch had higher recording levels for ethnicity and family history. The validation statistics for each of the risk prediction scores were very similar in the CPRD cohort compared with the published results from QResearch validation cohorts. For example, in women, the QDiabetes algorithm explained 50\% of the variation within CPRD compared with 51\% on QResearch and the receiver operator curve value was 0.85 on both databases. The scores were well calibrated in CPRD.
CONCLUSIONS: Each of the algorithms performed practically as well in the external independent CPRD validation cohorts as they had in the original published QResearch validation cohorts.},
	language = {eng},
	number = {8},
	journal = {BMJ open},
	author = {Hippisley-Cox, Julia and Coupland, Carol and Brindle, Peter},
	year = {2014},
	pmid = {25168040},
	pmcid = {PMC4156807},
	keywords = {Adult, Aged, Aged, 80 and over, Algorithms, Calibration, Cardiovascular Diseases, Cprd, Ethnic Groups, Family, Female, General Practice, Hemorrhage, Humans, Kidney Diseases, Male, Middle Aged, Osteoporotic Fractures, Prognosis, Prospective Studies, QResearch, Qrisk2, Risk, Validation, Venous Thromboembolism, diabetes mellitus},
	pages = {e005809}
}

@article{gawri_link_2014,
	title = {Link {N} is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity},
	volume = {32},
	issn = {1554-527X},
	doi = {10.1002/jor.22653},
	abstract = {Presently, there are no established treatments to prevent, stop or even retard back pain arising from disc degeneration. Previous studies have shown that Link N can act as a growth factor and stimulate the synthesis of proteoglycans and collagens, in IVD. However, the sequences in Link N involved in modulating cellular activity are not well understood. To determine if disc cells can proteolytically process Link N, human disc cells were exposed to native Link N over a 48 h period and mass spectrometric analysis revealed that a peptide spanning residues 1-8 was generated in the presence of AF cells but not NP cells. Link N 1-8 significantly induced proteoglycan production in the presence of IL-1β NP and AF cells, confirming that the biological effect is maintained in the first 8 amino acids of the peptide and indicating that the effect is sustained in an inflammatory environment. Thus Link-N 1-8 could be a promising candidate for biologically induced disc repair, and the identification of such a stable specific peptide may facilitate the design of compounds to promote disc repair and provide alternatives to surgical intervention for early stage disc degeneration.},
	language = {eng},
	number = {9},
	journal = {Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society},
	author = {Gawri, Rahul and Ouellet, Jean and Önnerfjord, Patrik and Alkhatib, Bashar and Steffen, Thomas and Heinegård, Dick and Roughley, Peter and Antoniou, John and Mwale, Fackson and Haglund, Lisbet},
	month = sep,
	year = {2014},
	pmid = {24861010},
	keywords = {Adolescent, Adult, Amino Acid Sequence, Animals, Biological Factors, Cattle, Cells, Cultured, Collagen, Female, Humans, IVD degeneration and regeneration, Intercellular Signaling Peptides and Proteins, Intervertebral Disc, Intervertebral Disc Degeneration, Link N, Lumbar Vertebrae, Male, Middle Aged, Molecular Sequence Data, Peptide Fragments, Proteoglycans, Regeneration, Thoracic Vertebrae, Young Adult, biological repair, organ culture},
	pages = {1189--1197},
}

@article{
 title = {How much do residential aged care staff members know about the nutritional needs of residents?},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Attitude of Health Personnel,Cross-Sectional Studies,Dementia/nursing,Female,Geriatric Nursing/methods,Health Care Surveys,Health Knowledge, Attitudes, Practice,Humans,Male,Malnutrition/nursing,Meals,Middle Aged,Nursing Staff,Nutrition Assessment,Quality of Life/psychology,Residential Facilities,malnutrition,mealtime practices,nutrition knowledge,old age,residential care,staff},
 pages = {54-64},
 volume = {9},
 month = {3},
 publisher = {Blackwell Publishing Ltd},
 city = {Dementia Collaborative Research Centre: Carers & Consumers, Queensland University of Technology, Brisbane, Australia; Dementia Training Studies Centre, Queensland University of Technology, Brisbane, Australia; School of Nursing, Queensland University of T},
 id = {ddcbb97d-cbf9-341d-982c-c02ae2ebd52c},
 created = {2016-08-20T16:52:30.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 74113; CI: (c) 2013; JID: 101267281; OTO: NOTNLM; 2012/08/03 [received]; 2012/11/21 [accepted]; 2013/02/11 [aheadofprint]; ppublish},
 folder_uuids = {06271a48-ad48-43cc-b073-52e57f10f5e1},
 private_publication = {false},
 abstract = {BACKGROUND: Undernutrition, weight loss and dehydration are major clinical issues for people with dementia in residential care, with excessive weight loss contributing to increased risk of frailty, immobility, illness and premature morbidity. This paper discusses a nutritional knowledge and attitudes survey conducted as part of a larger project focused on improving nutritional intake of people with dementia within a residential care facility in Brisbane, Australia. AIMS: The specific aims of the survey were to identify (i) knowledge of the nutritional needs of aged care facility residents; (ii) mealtime practices; and (iii) attitudes towards mealtime practices and organisation. METHODS: A survey based on those used in other healthcare settings was completed by 76 staff members. The survey included questions about nutritional knowledge, opinions of the food service, frequency of feeding assistance provided and feeding assessment practices. RESULTS: Nutritional knowledge scores ranged from 1 to 9 of a possible 10, with a mean score of 4.67. While 76% of respondents correctly identified risk factors associated with malnutrition in nursing home residents, only 38% of participants correctly identified the need for increased protein and energy in residents with pressure ulcers, and just 15% exhibited correct knowledge of fluid requirements. Further, while nutritional assessment was considered an important part of practice by 83% of respondents, just 53% indicated that they actually carried out such assessments. Identified barriers to promoting optimal nutrition included insufficient time to observe residents (56%); being unaware of residents' feeding issues (46%); poor knowledge of nutritional assessments (44%); and unappetising appearance of food served (57%). CONCLUSION: An important step towards improving health and quality of life for residents of aged care facilities would be to enhance staff nutritional awareness and assessment skills. This should be carried out through increased attention to both preservice curricula and on-the-job training. IMPLICATIONS FOR PRACTICE: The residential facility staff surveyed demonstrated low levels of nutrition knowledge, which reflects findings from the international literature. This has implications for the provision of responsive care to residents of these facilities and should be explored further.},
 bibtype = {article},
 author = {Beattie, E and O'Reilly, M and Strange, E and Franklin, S and Isenring, E},
 journal = {International journal of older people nursing},
 number = {1}
}

@article{taylor_all-cause_2013,
	title = {All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large {U}.{K}. primary care database},
	volume = {36},
	issn = {1935-5548},
	doi = {10.2337/dc12-1513},
	abstract = {OBJECTIVE: Middle-aged people with diabetes have been reported to have significantly higher risks of cardiovascular events than people without diabetes. However, recent falls in cardiovascular disease rates and more active management of risk factors may have abolished the increased risk. We aimed to provide an up-to-date assessment of the relative risks associated with type 2 diabetes of all-cause and cardiovascular mortality in middle-aged people in the U.K.
RESEARCH DESIGN AND METHODS: Using data from the General Practice Research Database, from 2004 to 2010, we conducted a cohort study of 87,098 people, 40-65 years of age at baseline, comparing 21,798 with type 2 diabetes and 65,300 without diabetes, matched on age, sex, and general practice. We produced hazard ratios (HRs) for mortality and compared rates of blood pressure testing, cholesterol monitoring, and use of aspirin, statins, and antihypertensive drugs. RESULTS People with type 2 diabetes, compared with people without diabetes, had a twofold increased risk of all-cause mortality (HR 2.07 [95\% CI 1.95-2.20], adjusted for smoking) and a threefold increased risk of cardiovascular mortality (3.25 [2.87-3.68], adjusted for smoking). Women had a higher relative risk than men, and people {\textless}55 years of age had a higher relative risk than those {\textgreater}55 years of age. Monitoring and medication rates were higher in those with diabetes (all P {\textless} 0.001).
CONCLUSIONS: Despite efforts to manage risk factors, administer effective treatments, and develop new therapies, middle-aged people with type 2 diabetes remain at significantly increased risk of death.},
	language = {eng},
	number = {8},
	journal = {Diabetes Care},
	author = {Taylor, Kathryn S. and Heneghan, Carl J. and Farmer, Andrew J. and Fuller, Alice M. and Adler, Amanda I. and Aronson, Jeffrey K. and Stevens, Richard J.},
	month = aug,
	year = {2013},
	pmid = {23435157},
	pmcid = {PMC3714501},
	keywords = {Adult, Cardiovascular Diseases, Cause of Death, Databases, Factual, Diabetes Mellitus, Type 2, Female, Great Britain, Humans, Male, Middle Aged, Risk, Sex Factors},
	pages = {2366--2371}
}

Paper  doi  abstract   bibtex   

@article{bourne_neuropsychological_2013,
	title = {Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis.},
	volume = {128},
	issn = {1600-0447},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23617548},
	doi = {10.1111/acps.12133},
	abstract = {OBJECTIVE: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view.

METHOD: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task.

RESULTS: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression.

CONCLUSION: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.},
	number = {3},
	urldate = {2015-05-01},
	journal = {Acta psychiatrica Scandinavica},
	author = {Bourne, C and Aydemir, Ö and Balanzá-Martínez, V and Bora, E and Brissos, S and Cavanagh, J T O and Clark, L and Cubukcuoglu, Z and Dias, V V and Dittmann, S and Ferrier, I N and Fleck, D E and Frangou, S and Gallagher, P and Jones, L and Kieseppä, T and Martínez-Aran, A and Melle, I and Moore, P B and Mur, M and Pfennig, A and Raust, A and Senturk, V and Simonsen, C and Smith, D J and Bio, D S and Soeiro-de-Souza, M G and Stoddart, S D R and Sundet, K and Szöke, A and Thompson, J M and Torrent, C and Zalla, T and Craddock, N and Andreassen, O A and Leboyer, M and Vieta, E and Bauer, M and Worhunsky, P D and Tzagarakis, C and Rogers, R D and Geddes, J R and Goodwin, G M},
	month = sep,
	year = {2013},
	pmid = {23617548},
	keywords = {Adult, Affect, Affective Symptoms, Affective Symptoms: psychology, Age of Onset, Bipolar Disorder, Bipolar Disorder: complications, Bipolar Disorder: diagnosis, Bipolar Disorder: drug therapy, Bipolar Disorder: epidemiology, Cognition Disorders, Cognition Disorders: diagnosis, Cognition Disorders: drug therapy, Cognition Disorders: epidemiology, Cognition Disorders: etiology, Confounding Factors (Epidemiology), Female, Humans, Male, Mental Competency, Mental Processes, Mental Processes: drug effects, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychotropic Drugs, Psychotropic Drugs: administration \& dosage, Psychotropic Drugs: adverse effects, Risk Factors},
	pages = {149--62},
}

@article{zhang_visible_2013,
	title = {Visible and near-infrared spectroscopy for distinguishing malignant tumor tissue from benign tumor and normal breast tissues in vitro},
	volume = {18},
	issn = {1560-2281},
	doi = {10.1117/1.JBO.18.7.077003},
	abstract = {The high incidence and mortality of breast cancer requires an effective, rapid, and cost-effective method for its diagnosis. Here, visible and near-infrared spectroscopy in the wavelength range of 400 to 2200 nm is utilized for distinguishing the malignant tumor tissue from benign tumor and normal breast tissues. Based on the absorption and scattering spectra of fixed samples, three spectral analysis methods are proposed which include an absorption spectral analysis, a scattering spectral analysis, and a combined spectral analysis of the two. By comparison with the histopathological examination, the sensitivity, specificity, and accuracy of the three analysis methods are calculated. The results showed that the combined spectral analysis method can significantly enhance the effectiveness when compared with the sole absorption or scattering spectral analysis method. The sensitivity, specificity, and accuracy of the combined spectral analysis method are 100\%, 87.82\%, and 87.50\% for the benign tumor tissue and 81.82\%, 100\%, and 87.5\% for malignant tumor tissue, respectively. All of the three values are 100\% for normal breast tissue. This study demonstrates that the combined spectral analysis method has better potential for in vitro optical diagnosis for breast lesions.},
	language = {eng},
	number = {7},
	journal = {Journal of Biomedical Optics},
	author = {Zhang, Yang and Chen, Yongjun and Yu, Yuan and Xue, Xingbo and Tuchin, Valery V. and Zhu, Dan},
	month = jul,
	year = {2013},
	pmid = {23839487},
	keywords = {Absorption, Breast, Breast Neoplasms, Female, Humans, Image Processing, Computer-Assisted, Reference Values, Scattering, Radiation, Sensitivity and Specificity, Spectroscopy, Near-Infrared},
	pages = {077003},
}

@article{ jit_key_2013,
  title = {Key issues for estimating the impact and cost-effectiveness of seasonal influenza vaccination strategies},
  volume = {9},
  issn = {2164-554X},
  doi = {10.4161/hv.23637},
  abstract = {Many countries have considered or are considering modifying their seasonal influenza immunization policies. Estimating the impact of such changes requires understanding the existing clinical and economic burden of influenza, as well as the potential impact of different vaccination options. Previous studies suggest that vaccinating clinical risk groups, health care workers, children and the elderly may be cost-effective. However, challenges in such estimation include: (1) potential cases are not usually virologically tested; (2) cases have non-specific symptoms and are rarely reported to surveillance systems; (3) endpoints for influenza proxies (such as influenza-like illness) need to be matched to case definitions for treatment costs, (4) disease burden estimates vary from year to year with strain transmissibility, virulence and prior immunity, (5) methods to estimate productivity losses due to influenza vary, (6) vaccine efficacy estimates from trials differ due to variation in subtype prevalence, vaccine match and case ascertainment, and (7) indirect (herd) protection from vaccination depends on setting-specific variables that are difficult to directly measure. Given the importance of knowing the impact of changes to influenza policy, such complexities need careful treatment using tools such as population-based trial designs, meta-analyses, time-series analyses and transmission dynamic models.},
  language = {eng},
  number = {4},
  journal = {Human Vaccines \& Immunotherapeutics},
  author = {Jit, Mark and Newall, Anthony T. and Beutels, Philippe},
  month = {April},
  year = {2013},
  pmid = {23357859},
  pmcid = {PMC3903903},
  keywords = {Cost-Benefit Analysis, Humans, Influenza Vaccines, Influenza, Human, Vaccination},
  pages = {834--840}
}

Website  abstract   bibtex   

@article{
 title = {Are forward and backward recall the same? A dual-task study of digit recall.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Adult,Attention,Attention: physiology,Executive Function,Executive Function: physiology,Humans,Mathematical Concepts,Mental Recall,Mental Recall: physiology,Space Perception,Space Perception: physiology,Young Adult},
 pages = {519-32},
 volume = {41},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/23263876},
 id = {99159d3e-5274-3213-bef9-d024aca4812a},
 created = {2016-01-12T16:04:56.000Z},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {There is some debate surrounding the cognitive resources underlying backward digit recall. Some researchers consider it to differ from forward digit recall due to the involvement of executive control, while others suggest that backward recall involves visuospatial resources. Five experiments therefore investigated the role of executive-attentional and visuospatial resources in both forward and backward digit recall. In the first, participants completed visuospatial 0-back and 2-back tasks during the encoding of information to be remembered. The concurrent tasks did not differentially disrupt performance on backward digit recall, relative to forward digit recall. Experiment 2 shifted concurrent load to the recall phase instead and, in this case, revealed a larger effect of both tasks on backward recall, relative to forwards recall, suggesting that backward recall may draw on additional resources during the recall phase and that these resources are visuospatial in nature. Experiments 3 and 4 then further investigated the role of visual processes in forward and backward recall using dynamic visual noise (DVN). In Experiment 3, DVN was presented during encoding of information to be remembered and had no effect upon performance. However, in Experiment 4, it was presented during the recall phase, and the results provided evidence of a role for visual imagery in backward digit recall. These results were replicated in Experiment 5, in which the same list length was used for forward and backward recall tasks. The findings are discussed in terms of both theoretical and practical implications.},
 bibtype = {article},
 author = {St Clair-Thompson, H. L. and Allen, R. J.},
 journal = {Memory & cognition},
 number = {4}
}

Paper  doi  abstract   bibtex   

@article{sollie_comparison_2013,
	title = {Comparison of mother, father, and teacher reports of {ADHD} core symptoms in a sample of child psychiatric outpatients.},
	volume = {17},
	issn = {1557-1246},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22441890},
	doi = {10.1177/1087054711436010},
	abstract = {OBJECTIVE: To explore the significance of adding father ratings to mother and teacher ratings in the assessment of ADHD symptoms in children.

METHOD: The ADHD Rating Scale-IV, the Child Behavior Checklist, and the Teacher Report Form were filled out by all three informants for a sample of 48 clinically referred children (79\% boys) aged 6 to 15 (M = 10.1) years.

RESULTS: Correspondence between father and teacher reports on ADHD-specific symptoms (intraclass correlation coefficient [ICC] = .38) exceeded that between mothers and teachers (ICC = .23). Fathers rated their children as having fewer problems than did mothers and teachers on Total scale scores and the Inattention subscale of the ADHD Rating Scale-IV. Mother ratings were more sensitive to an ADHD diagnosis, whereas father ratings better predicted an ADHD diagnosis requiring the two-setting criterion.

CONCLUSION: The choice of parent informant and informant combination had a considerable impact on parent-teacher concordance and estimates of ADHD symptoms and subtypes in the child.},
	number = {8},
	urldate = {2015-05-12},
	journal = {Journal of attention disorders},
	author = {Sollie, Henrik and Larsson, Bo and Mørch, Willy-Tore},
	month = nov,
	year = {2013},
	pmid = {22441890},
	keywords = {Adolescent, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: dia, Child, Faculty, Fathers, Female, Humans, Male, Mothers, Outpatients, Outpatients: psychology, Symptom Assessment},
	pages = {699--710},
}

Paper  doi  abstract   bibtex   

@article{burgess_does_2012,
	title = {Does stereotype threat affect women in academic medicine?},
	volume = {87},
	issn = {1938-808X},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3315611&tool=pmcentrez&rendertype=abstract},
	doi = {10.1097/ACM.0b013e318248f718},
	abstract = {Multiple complex factors contribute to the slow pace of women's advancement into leadership positions in academic medicine. In this article, the authors propose that stereotype threat–under which individuals who are members of a group characterized by negative stereotypes in a particular domain perform below their actual abilities in that domain when group membership is emphasized–may play an important role in the underrepresentation of women in leadership positions in academic medicine. Research to objectively assess the impact of stereotype threat for women in academic medicine is feasible and necessary to confirm this hypothesis. Still, a number of conditions present in the academic medicine community today have been shown to trigger stereotype threat in other settings, and stereotype threat fits with existing research on gender in academic medicine. In the meantime, academic health centers should implement relatively simple measures supported by experimental evidence from other settings to reduce the risk of stereotype threat, including (1) introducing the concept of stereotype threat to the academic medicine community, (2) engaging all stakeholders, male and female, to promote identity safety by enacting and making faculty aware of policies to monitor potential instances of discrimination, and training faculty to provide performance feedback that is free of gender bias, (3) counteracting the effects of sex segregation at academic health centers by increasing exposure to successful female leaders, (4) reducing gender stereotype priming by avoiding stereotypically male criteria for promotion, grants, and awards, and (5) building leadership efficacy among female physicians and scientists.},
	number = {4},
	journal = {Academic Medicine},
	author = {Burgess, Diana Jill and Joseph, Anne and van Ryn, Michelle and Carnes, Molly},
	month = apr,
	year = {2012},
	pmid = {22361794},
	keywords = {Academic Medical Centers, Academic Medical Centers: organization \& administr, Achievement, Faculty, Female, Humans, Leadership, Male, Prejudice, Stereotyping, Women's Rights, medical, physicians, women},
	pages = {506--12},
}

@article{ radua_new_2012,
  title = {A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps},
  volume = {27},
  issn = {1778-3585},
  doi = {10.1016/j.eurpsy.2011.04.001},
  abstract = {Meta-analyses are essential to summarize the results of the growing number of neuroimaging studies in psychiatry, neurology and allied disciplines. Image-based meta-analyses use full image information (i.e. the statistical parametric maps) and well-established statistics, but images are rarely available making them highly unfeasible. Peak-probability meta-analyses such as activation likelihood estimation (ALE) or multilevel kernel density analysis (MKDA) are more feasible as they only need reported peak coordinates. Signed-differences methods, such as signed differential mapping (SDM) build upon the positive features of existing peak-probability methods and enable meta-analyses of studies comparing patients with controls. In this paper we present a new version of SDM, named Effect Size SDM (ES-SDM), which enables the combination of statistical parametric maps and peak coordinates and uses well-established statistics. We validated the new method by comparing the results of an ES-SDM meta-analysis of studies on the brain response to fearful faces with the results of a pooled analysis of the original individual data. The results showed that ES-SDM is a valid and reliable coordinate-based method, whose performance might be additionally increased by including statistical parametric maps. We anticipate that ES-SDM will be a helpful tool for researchers in the fields of psychiatry, neurology and allied disciplines.},
  language = {eng},
  number = {8},
  journal = {European Psychiatry: The Journal of the Association of European Psychiatrists},
  author = {Radua, J. and Mataix-Cols, D. and Phillips, M. L. and El-Hage, W. and Kronhaus, D. M. and Cardoner, N. and Surguladze, S.},
  month = {November},
  year = {2012},
  pmid = {21658917},
  keywords = {Adult, Brain, Brain Mapping, Facial Expression, Humans, Magnetic Resonance Imaging, Neuroimaging, Neuropsychological Tests, Reproducibility of Results},
  pages = {605--611}
}

Website  abstract   bibtex   

@article{
 title = {Quantitative evaluation of white matter tract DTI parameter changes in gliomas using nonlinear registration.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Anisotropy,Brain Mapping,Brain Mapping: methods,Brain Neoplasms,Brain Neoplasms: pathology,Computer-Assisted,Diffusion Magnetic Resonance Imaging,Diffusion Magnetic Resonance Imaging: methods,Female,Glioma,Glioma: pathology,Humans,Image Interpretation,Male,Middle Aged},
 pages = {2309-15},
 volume = {60},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22387173},
 month = {5},
 day = {1},
 id = {52c453a0-39cf-3063-98b2-f969182bb93f},
 created = {2014-02-21T01:56:21.000Z},
 accessed = {2014-01-28},
 file_attached = {false},
 profile_id = {c9197201-0e1b-30a7-a154-39d024463beb},
 last_modified = {2017-03-16T10:25:05.903Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Diffusion tensor imaging (DTI) has been used extensively to investigate white matter architecture in the brain. In the context of neurological disease, quantification of DTI data sets enables objective characterisation of the associated pathological changes. The aim of this study is to propose a method of evaluating DTI parameter changes in gliomas in the internal capsule using nonlinear registration to delineate the white matter and enable quantitative assessment of DTI derived parameters. 20 patients selected pre-operatively with probable grade 2 or grade 3 glioma on structural MRI along with ten normal volunteers were included in this study. DTI fractional anisotropy (FA) maps were used to define a common segmented FA skeleton that was projected back onto the original individual FA maps. Objective segment classification as normal or abnormal was achieved by comparison to prediction intervals of FA and mean diffusivity (MD) defined in normal subjects. The internal capsules of each patient were segmented into 10 regions of interest (ROI) with 20 and 16 segments across the group having significantly increased or decreased FA and MD values respectively. Seven glioma patients had abnormal DTI parameters in the internal capsule. We show that the classification of tract segments was consistent with disruption, oedema or compression. The results suggest that this method could be used to detect changes in eloquent white matter tracts in individual patients.},
 bibtype = {article},
 author = {Miller, P and Coope, D and Thompson, G and Jackson, A and Herholz, K},
 journal = {NeuroImage},
 number = {4}
}

Paper  doi  abstract   bibtex   

@article{deary_intelligence._2012,
	title = {Intelligence.},
	volume = {63},
	issn = {1545-2085},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21943169},
	doi = {10.1146/annurev-psych-120710-100353},
	abstract = {Individual differences in human intelligence are of interest to a wide range of psychologists and to many people outside the discipline. This overview of contributions to intelligence research covers the first decade of the twenty-first century. There is a survey of some of the major books that appeared since 2000, at different levels of expertise and from different points of view. Contributions to the phenotype of intelligence differences are discussed, as well as some contributions to causes and consequences of intelligence differences. The major causal issues covered concern the environment and genetics, and how intelligence differences are being mapped to brain differences. The major outcomes discussed are health, education, and socioeconomic status. Aging and intelligence are discussed, as are sex differences in intelligence and whether twins and singletons differ in intelligence. More generally, the degree to which intelligence has become a part of broader research in neuroscience, health, and social science is discussed.},
	urldate = {2012-07-13},
	journal = {Annual review of psychology},
	author = {Deary, Ian J},
	month = jan,
	year = {2012},
	pmid = {21943169},
	keywords = {Aging, Aging: genetics, Cognition, Educational Status, Environment, Humans, Individuality, Intelligence, Intelligence Tests, Intelligence: genetics, Social Class, Twins, Twins: genetics},
	pages = {453--82},
}

@article{best_recovery_2012,
	title = {The recovery paradigm - a model of hope and change for alcohol and drug addiction},
	volume = {41},
	issn = {0300-8495},
	abstract = {BACKGROUND: Alcohol and drug disorders remain major health and social problems in Australia, contributing enormously to the global burden of disease and the everyday practice of primary care. A recent growth in recovery research and recovery focused policies are starting to have an impact in Australia, with implications for how we attempt to resolve these problems.
OBJECTIVE: In this article we discuss recent international findings in recovery research, and explore their implications for primary care.
DISCUSSION: Research indicates that over half of dependent substance users will eventually achieve stable recovery. Key predictors of recovery are active engagement in the community and immersion in peer support groups and activities. Recovery requires a twin track approach: enabling and supporting individual recovery journeys, while creating environmental conditions that enable and support a 'social contagion' of recovery, in which recovery is transmitted through supportive social networks and dedicated recovery groups, such as mutual aid.},
	language = {eng},
	number = {8},
	journal = {Australian Family Physician},
	author = {Best, David W. and Lubman, Dan I.},
	month = aug,
	year = {2012},
	pmid = {23145400},
	keywords = {Adaptation, Psychological, Alcoholism, General Practice, Humans, Models, Theoretical, Self-Help Groups, Social Support, Substance-Related Disorders},
	pages = {593--597},
}

Website  abstract   bibtex   

@article{
 title = {Blood/air distribution of volatile organic compounds (VOCs) in a nationally representative sample.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Air Pollutants,Air Pollutants: analysis,Air Pollutants: blood,Child,Chlorobenzenes,Chlorobenzenes: analysis,Chlorobenzenes: blood,Drinking Water,Environmental Monitoring,Female,Gas Chromatography-Mass Spectrometry,Humans,Linear Models,Male,Middle Aged,Multivariate Analysis,Nutrition Surveys,Questionnaires,Smoking,Smoking: blood,Solid Phase Microextraction,United States,Volatile Organic Compounds,Volatile Organic Compounds: analysis,Volatile Organic Compounds: blood,Young Adult},
 pages = {225-32},
 volume = {419},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22285084},
 publisher = {Elsevier B.V.},
 id = {33341907-add2-3a89-9999-74cba0377b37},
 created = {2015-03-09T20:40:30.000Z},
 file_attached = {true},
 profile_id = {03bdbf9c-0848-344e-95e3-9d552532f95c},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 folder_uuids = {94112c8a-2c34-4696-add4-3937d89cec61},
 private_publication = {false},
 abstract = {Volatile organic compounds (VOCs) in human blood are an effective biomarker of environmental exposure and are closely linked to health outcomes. Unlike VOC concentrations in air, which are routinely collected, blood VOC data are not as readily available. This study aims to develop the quantitative relationship between air and blood VOCs by deriving population-based blood/air distribution coefficients (popKs) of ten common VOCs in the general U.S. population. Air and human blood samples were collected from 364 adults aged 20-59 years in 1999-2000 National Health and Nutrition Examination Survey (NHANES). Determinants of popKs were identified using weighted multivariate regression models. In the non-smoking population, median popKs ranged from 3.1 to 77.3, comparable to values obtained in the laboratory. PopKs decreased with increasing airborne VOC concentrations. Smoking elevated popKs by 1.5-3.5 times for aromatic compounds, but did not affect the popKs for methyl tert-butyl ether (MTBE) or chlorinated compounds. Drinking water concentration was a modifier of MTBE's popK. Age, gender, body composition, nor ethnicity affected popKs. PopKs were predictable using linear models with air concentration as the independent variable for both adults and children. This is the first study to estimate blood/air distribution coefficients using simultaneous environmental and biological monitoring on a national population sample. This study was also the first to determine the blood/air distribution coefficient of p-dichlorobenzene, a compound frequently found in indoor environments. These results have applications in exposure assessment, pharmacokinetic analysis, physiologically-based pharmacokinetic (PBPK) modeling, and uncertainty analysis.},
 bibtype = {article},
 author = {Jia, Chunrong and Yu, Xinhua and Masiak, Wasim},
 journal = {The Science of the total environment}
}

Paper  doi  abstract   bibtex   

@article{Chen2011,
	title = {Contribution of telomere {G}-quadruplex stabilization to the inhibition of telomerase-mediated telomere extension by chemical ligands.},
	volume = {133},
	issn = {1520-5126},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21846102},
	doi = {10.1021/ja204326w},
	abstract = {Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate the contribution of G-quadruplex stabilization to the overall inhibition. Using a modified telomere repeat amplification protocol (TRAP) method to differentiate the telomere G-quadruplex independent effect from dependent ones, we analyzed several ligands that have high affinity and/or selectivity to telomere G-quadruplex. Our results show that these ligands effectively inhibited telomerase activity in the absence of telomere G-quadruplex. The expected G-quadruplex-dependent inhibition was only obvious for the cationic ligands at low K(+) concentration, but it dramatically decreased at physiological concentration of K(+). These observations demonstrate that the ligands are much more than G-quadruplex stabilizers with a strong G-quadruplex-irrelevant off-target effect. They inhibit telomerase via multiple pathways in which stabilization of telomere G-quadruplex may only make a minor or neglectable contribution under physiologically relevant conditions depending on the stability of telomere G-quadruplex under ligand-free conditions.},
	number = {38},
	journal = {Journal of the American Chemical Society},
	author = {Chen, Chang-yue and Wang, Quan and Liu, Jia-quan and Hao, Yu-hua and Tan, Zheng},
	month = oct,
	year = {2011},
	pmid = {21846102},
	keywords = {\#nosource, Carbazoles, Carbazoles: chemistry, Carbazoles: pharmacology, Dose-Response Relationship, Drug, G-Quadruplexes, Humans, Indoles, Indoles: chemistry, Indoles: pharmacology, Ligands, Organometallic Compounds, Organometallic Compounds: chemistry, Organometallic Compounds: pharmacology, Pyridinium Compounds, Pyridinium Compounds: chemistry, Pyridinium Compounds: pharmacology, Structure-Activity Relationship, Telomerase, Telomerase: antagonists \& inhibitors, Telomerase: genetics, Telomerase: metabolism, Telomere, Telomere: chemistry},
	pages = {15036--44},
}

Paper  doi  abstract   bibtex   

@article{rommelse_review_2011,
	title = {A review on cognitive and brain endophenotypes that may be common in autism spectrum disorder and attention-deficit/hyperactivity disorder and facilitate the search for pleiotropic genes.},
	volume = {35},
	issn = {1873-7528},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21382410},
	doi = {10.1016/j.neubiorev.2011.02.015},
	abstract = {We propose to bring together the hitherto rather separate research fields of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), and argue that by contrasting and combining findings of the endophenotypes of ASD and ADHD new insights can be gained into the etiology and pathophysiology of these two disorders. Given the highly heritable nature of both disorders, studies of the genes explaining the shared origins of the two neurodevelopmental disorders seem particularly called for. Instead of the clinical diagnosis, using neurocognitive measures as (endo)phenotypes that index genetic liability appears a powerful tool in gene finding. We, therefore, extensively reviewed the literature and not only included research wherein ASD and ADHD were compared within a single study, but extended our search also to the separate lines of cognitive neuroscience research. We discuss which cognitive and brain measures will be useful in future genetic studies targeting pleiotropic genes for ASD and ADHD. By specifying the most promising endophenotypic measures we chart the future course for endophenotypic research in ASD and ADHD. We also discuss the various models that may explain the frequent co-occurrence of ASD and ADHD.},
	number = {6},
	urldate = {2015-01-15},
	journal = {Neuroscience and biobehavioral reviews},
	author = {Rommelse, Nanda N J and Geurts, Hilde M and Franke, Barbara and Buitelaar, Jan K and Hartman, Catharina A},
	month = may,
	year = {2011},
	pmid = {21382410},
	keywords = {Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: gen, Brain, Brain: metabolism, Child, Child Development Disorders, Pervasive, Child Development Disorders, Pervasive: genetics, Cognition, Cognition: physiology, Endophenotypes, Genetic Pleiotropy, Humans},
	pages = {1363--96},
}

Paper  abstract   bibtex   

@article{
 title = {Complications associated with the treatment for spinal ependymomas.},
 type = {article},
 year = {2011},
 identifiers = {[object Object]},
 keywords = {Antineoplastic Agents,Antineoplastic Agents: adverse effects,Antineoplastic Agents: therapeutic use,Ependymoma,Ependymoma: epidemiology,Ependymoma: radiography,Ependymoma: therapy,Humans,Microsurgery,Microsurgery: adverse effects,Postoperative Complications,Postoperative Complications: epidemiology,Postoperative Complications: etiology,Postoperative Complications: radiography,Spinal Neoplasms,Spinal Neoplasms: epidemiology,Spinal Neoplasms: radiography,Spinal Neoplasms: therapy,Treatment Outcome},
 pages = {E13},
 volume = {31},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/21961857},
 month = {10},
 id = {6f050f7e-bedf-3314-9837-4ee8fc588558},
 created = {2013-09-11T03:07:32.000Z},
 accessed = {2013-09-10},
 file_attached = {true},
 profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-11-22T16:36:55.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Spinal cord ependymomas are rare neoplasms, comprising approximately 5% of all CNS tumors and 15% of all spinal cord tumors. Although surgery was once reserved for diagnosis alone, the evolution of surgical practices has elevated resection to the treatment of choice for these lesions. While technological advances continue to improve the capacity for gross-total resections and thus decrease the risk of recurrence, ependymoma spinal surgery still contains a variety of potential complications. The presence of neurological deficits and deterioration are not uncommonly associated with spinal cord ependymoma surgery, including sensory loss, dorsal column dysfunction, dysesthetic syndrome, and bowel and bladder dysfunction, particularly in the immediate postoperative period. Surgical treatment may also lead to wound complications and CSF leaks, with increased risk when radiotherapy has been involved. Radiation therapy may also predispose patients to radiation myelopathy and ultimately result in neurological damage. Additionally, resections of spinal ependymomas have been associated with postoperative spinal instability and deformities, particularly in the pediatric population. Despite the advances in microsurgical techniques and intraoperative cord monitoring modalities, there remain a number of serious complications related to the treatment of spinal ependymoma tumors. Identification and acknowledgment of these potential problems may assist in their prevention, early detection, and increased quality of life for patients afflicted with this disease.},
 bibtype = {article},
 author = {Nagasawa, Daniel T and Smith, Zachary a and Cremer, Nicole and Fong, Christina and Lu, Daniel C and Yang, Isaac},
 journal = {Neurosurgical Focus},
 number = {4}
}

Paper  Website  abstract   bibtex   

@article{
 title = {iqr: A Tool for the Construction of Multi-level Simulations of Brain and Behaviour.},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Access to Information,Animal,Animals,Behavior,Behavior: physiology,Brain,Brain: physiology,Computer Simulation,Humans,Insects,Internet,Memory,Memory: physiology,Models,Neurological,Neurons,Neurons: physiology,Robotics,Software,Synapses,Synapses: physiology,Time Factors,User-Computer Interface},
 pages = {113-34},
 volume = {8},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/20502987},
 publisher = {Humana Press Inc.},
 id = {59515ef3-1a82-3d32-b933-751e65c1b13e},
 created = {2016-02-18T20:36:44.000Z},
 file_attached = {true},
 profile_id = {666a093a-6015-3506-8b43-c65cadb20ea2},
 last_modified = {2017-03-09T23:31:28.082Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bernardet2010},
 source_type = {article},
 folder_uuids = {2e9f9bfc-4801-4871-9757-39a0ad79563e,79387ff2-9353-4bd0-8477-6c81b81f953f},
 abstract = {The brain is the most complex system we know of. Despite the wealth of data available in neuroscience, our understanding of this system is still very limited. Here we argue that an essential component in our arsenal of methods to advance our understanding of the brain is the construction of artificial brain-like systems. In this way we can encompass the multi-level organisation of the brain and its role in the context of the complete embodied real-world and real-time perceiving and behaving system. Hence, on the one hand, we must be able to develop and validate theories of brains as closing the loop between perception and action, and on the other hand as interacting with the real world. Evidence is growing that one of the sources of the computational power of neuronal systems lies in the massive and specific connectivity, rather than the complexity of single elements. To meet these challenges-multiple levels of organisation, sophisticated connectivity, and the interaction of neuronal models with the real-world-we have developed a multi-level neuronal simulation environment, iqr. This framework deals with these requirements by directly transforming them into the core elements of the simulation environment itself. iqr provides a means to design complex neuronal models graphically, and to visualise and analyse their properties on-line. In iqr connectivity is defined in a flexible, yet compact way, and simulations run at a high speed, which allows the control of real-world devices-robots in the broader sense-in real-time. The architecture of iqr is modular, providing the possibility to write new neuron, and synapse types, and custom interfaces to other hardware systems. The code of iqr is publicly accessible under the GNU General Public License (GPL). iqr has been in use since 1996 and has been the core tool for a large number of studies ranging from detailed models of neuronal systems like the cerebral cortex, and the cerebellum, to robot based models of perception, cognition and action to large-scale real-world systems. In addition, iqr has been widely used over many years to introduce students to neuronal simulation and neuromorphic control. In this paper we outline the conceptual and methodological background of iqr and its design philosophy. Thereafter we present iqr's main features and computational properties. Finally, we describe a number of projects using iqr, singling out how iqr is used for building a "synthetic insect".},
 bibtype = {article},
 author = {Bernardet, Ulysses and Verschure, Paul F.M.J.},
 journal = {Neuroinformatics},
 number = {2}
}

@article{laumet_study_2010,
	title = {A study of the association between the {ADAM12} and {SH3PXD2A} ({SH3MD1}) genes and {Alzheimer}'s disease},
	volume = {468},
	issn = {1872-7972},
	doi = {10.1016/j.neulet.2009.10.040},
	abstract = {Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to beta-amyloid (Abeta) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Abeta. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.},
	language = {eng},
	number = {1},
	journal = {Neuroscience Letters},
	author = {Laumet, Geoffroy and Petitprez, Vincent and Sillaire, Adeline and Ayral, Anne-Marie and Hansmannel, Franck and Chapuis, Julien and Hannequin, Didier and Pasquier, Florence and Scarpini, Elio and Galimberti, Daniela and Lendon, Corinne and Campion, Dominique and Amouyel, Philippe and Lambert, Jean-Charles},
	month = jan,
	year = {2010},
	pmid = {19837132},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Genetic Predisposition to Disease, Risk Factors, Case-Control Studies, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Membrane Proteins, ADAM Proteins, ADAM12 Protein, Adaptor Proteins, Vesicular Transport},
	pages = {1--2}
}

@article {93,
	title = {Medical treatment of autism spectrum disorders},
	journal = {Current Opinion in Neurology},
	volume = {23},
	number = {2},
	year = {2010},
	note = {LR: 20130118; GR: UA3 MC 11054/PHS HHS/United States; JID: 9319162; RF: 53; ppublish},
	month = {Apr},
	pages = {131-136},
	abstract = {PURPOSE OF REVIEW: There are several common medical conditions occurring in people with autism spectrum disorders (ASD) that can benefit from treatment and can in turn improve the health and quality of life of people with ASD. This review will primarily focus on these medical comorbidities, with a brief review of potential future treatments. RECENT FINDINGS: There continues to be disagreement regarding the exact prevalence and etiological significance of gastrointestinal conditions, epilepsy and other abnormal electroencephalographic findings, and sleep problems. It is not clear whether gastrointestinal conditions occur more frequently than in typically developing children, and whether there are distinct conditions that occur more often in ASD than in non-ASD populations. Abnormal electroencephalographic findings have been reported in up to 60\% of children with ASD, and some believe that these abnormalities may be responsible for parts of the ASD phenotype. Sleep problems are reported more frequently than in the general population, and effective treatments are available. Future medical treatments for ASD may be directed at underlying core symptoms and have greater impact than today{\textquoteright}s symptomatic approach. SUMMARY: Further research in these areas is needed to better guide diagnosis and treatment of a variety of medical conditions experienced by people with ASD.},
	keywords = {Animals, Brain Diseases/diagnosis/physiopathology/therapy, Child, Child Development Disorders, Gastrointestinal Diseases/diagnosis/physiopathology/therapy, Humans, Pervasive/diagnosis/physiopathology/therapy, Sleep Disorders/diagnosis/physiopathology/therapy},
	isbn = {1473-6551; 1350-7540},
	author = {Daniel L Coury}
}

@article{hofmann_living_2010,
	title = {Living in the now: {Physiological} mechanisms to tolerate a rapidly changing environment.},
	volume = {72},
	journal = {Annual Review of Physiology},
	author = {Hofmann, G. E. and Todgham, A. E.},
	year = {2010},
	keywords = {disturbance, MCR, populations}
}

@article{spyrou_compounds_2010,
	title = {Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.},
	volume = {44},
	copyright = {Copyright (c) 2009 Elsevier Inc. All rights reserved.},
	issn = {1096-0961 1079-9796},
	doi = {10.1016/j.bcmd.2009.10.008},
	language = {eng},
	number = {2},
	journal = {Blood cells, molecules \& diseases},
	author = {Spyrou, Pandelis and Phylactides, Marios and Lederer, Carsten W. and Kithreotis, Lucas and Kirri, Andriani and Christou, Soteroulla and Kkolou, Elena and Kanavakis, Emanuel and Anagnou, Nicholas P. and Stamatoyannopoulos, George and Kleanthous, Marina},
	month = apr,
	year = {2010},
	pmid = {19914848},
	note = {Place: United States},
	keywords = {Animals, Anthracyclines/administration \& dosage/*pharmacology, Anti-Bacterial Agents/administration \& dosage/*pharmacology, Cell Line, Cells, Cultured, Erythroid Cells/drug effects, Fetal Hemoglobin/genetics/metabolism, Gene Expression Regulation/*drug effects, Humans, Mice, Mice, Transgenic, Promoter Regions, Genetic/drug effects, RNA, Messenger/genetics, Thalassemia/drug therapy/genetics, beta-Globins/genetics, gamma-Globins/*genetics},
	pages = {100--106},
}

@article{giudice_clinical_2010,
	title = {Clinical practice. {Endometriosis}},
	volume = {362},
	issn = {1533-4406},
	doi = {10.1056/NEJMcp1000274},
	language = {eng},
	number = {25},
	journal = {The New England Journal of Medicine},
	author = {Giudice, Linda C.},
	month = jun,
	year = {2010},
	pmid = {20573927},
	pmcid = {PMC3108065},
	keywords = {Dysmenorrhea, Dyspareunia, Endometriosis, Female, Humans, Infertility, Female, Pelvic Pain},
	pages = {2389--2398}
}

@article{may_peripheral_2010,
	title = {Peripheral biomarkers of endometriosis: a systematic review},
	volume = {16},
	issn = {1460-2369},
	shorttitle = {Peripheral biomarkers of endometriosis},
	doi = {10.1093/humupd/dmq009},
	abstract = {BACKGROUND: Endometriosis is estimated to affect 1 in 10 women during the reproductive years. There is often delay in making the diagnosis, mainly due to the non-specific nature of the associated symptoms and the need to verify the disease surgically. A biomarker that is simple to measure could help clinicians to diagnose (or at least exclude) endometriosis; it might also allow the effects of treatment to be monitored. If effective, such a marker or panel of markers could prevent unnecessary diagnostic procedures and/or recognize treatment failure at an early stage.
METHODS: We used QUADAS (Quality Assessment of Diagnostic Accuracy Studies) criteria to perform a systematic review of the literature over the last 25 years to assess critically the clinical value of all proposed biomarkers for endometriosis in serum, plasma and urine.
RESULTS: We identified over 100 putative biomarkers in publications that met the selection criteria. We were unable to identify a single biomarker or panel of biomarkers that have unequivocally been shown to be clinically useful.
CONCLUSIONS: Peripheral biomarkers show promise as diagnostic aids, but further research is necessary before they can be recommended in routine clinical care. Panels of markers may allow increased sensitivity and specificity of any diagnostic test.},
	language = {eng},
	number = {6},
	journal = {Human Reproduction Update},
	author = {May, K. E. and Conduit-Hulbert, S. A. and Villar, J. and Kirtley, S. and Kennedy, S. H. and Becker, C. M.},
	month = dec,
	year = {2010},
	pmid = {20462942},
	pmcid = {PMC2953938},
	keywords = {Antibodies, Apoptosis, Biomarkers, Cell Adhesion, Cytokines, Endometriosis, Female, Glycoproteins, Hormones, Humans, Intercellular Signaling Peptides and Proteins, Leukocytes, Proteomics, Vascular Endothelial Growth Factor A},
	pages = {651--674}
}

Paper  doi  abstract   bibtex   

@article{fellman_one-year_2009,
	title = {One-year survival of extremely preterm infants after active perinatal care in {Sweden}.},
	volume = {301},
	issn = {1538-3598},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19491184},
	doi = {10.1001/jama.2009.771},
	abstract = {CONTEXT: Up-to-date information on infant survival after extremely preterm birth is needed for assessing perinatal care services, clinical guidelines, and parental counseling.

OBJECTIVE: To determine the 1-year survival in all infants born before 27 gestational weeks in Sweden during 2004-2007.

DESIGN, SETTING, AND PATIENTS: Population-based prospective observational study of extremely preterm infants (707 live-born and 304 stillbirths) born to 887 mothers in 904 deliveries (102 multiple births) in all obstetric and neonatal units in Sweden from April 1, 2004, to March 31, 2007.

MAIN OUTCOME MEASURES: Infant survival to 365 days and survival without major neonatal morbidity (intraventricular hemorrhage grade {\textgreater}2, retinopathy of prematurity stage {\textgreater}2, periventricular leukomalacia, necrotizing enterocolitis, severe bronchopulmonary dysplasia). Associations between perinatal interventions and survival.

RESULTS: The incidence of extreme prematurity was 3.3 per 1000 infants. Overall perinatal mortality was 45\% (from 93\% at 22 weeks to 24\% at 26 weeks), with 30\% stillbirths, including 6.5\% intrapartum deaths. Of live-born infants, 91\% were admitted to neonatal intensive care and 70\% survived to 1 year of age (95\% confidence interval [CI], 67\%-73\%). The Kaplan-Meier survival estimates for 22, 23, 24, 25, and 26 weeks were 9.8\% (95\% CI, 4\%-23\%), 53\% (95\% CI, 44\%-63\%), 67\% (95\% CI, 59\%-75\%), 82\% (95\% CI, 76\%-87\%), and 85\% (95\% CI, 81\%-90\%), respectively. Lower risk of infant death was associated with tocolytic treatment (adjusted for gestational age odds ratio [OR], 0.43; 95\% CI, 0.36-0.52), antenatal corticosteroids (OR, 0.44; 95\% CI, 0.24-0.81), surfactant treatment within 2 hours after birth (OR, 0.47; 95\% CI, 0.32-0.71), and birth at a level III hospital (OR, 0.49; 95\% CI, 0.32-0.75). Among 1-year survivors, 45\% had no major neonatal morbidity.

CONCLUSION: During 2004 to 2007, 1-year survival of infants born alive at 22 to 26 weeks of gestation in Sweden was 70\% and ranged from 9.8\% at 22 weeks to 85\% at 26 weeks.},
	number = {21},
	urldate = {2015-05-26},
	journal = {JAMA},
	author = {Fellman, Vineta and Hellström-Westas, Lena and Norman, Mikael and Westgren, Magnus and Källén, Karin and Lagercrantz, Hugo and Marsál, Karel and Serenius, Fredrik and Wennergren, Margareta},
	month = jun,
	year = {2009},
	pmid = {19491184},
	keywords = {Female, Gestational Age, Humans, Infant, Infant Mortality, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Infant, Premature, Diseases: mortality, Intensive Care, Neonatal, Male, Morbidity, Perinatal Care, Perinatal Mortality, Pregnancy, Premature Birth, Prospective Studies, Risk, Survival Analysis, Sweden, Sweden: epidemiology},
	pages = {2225--33},
}

Paper  Website  abstract   bibtex   

@article{
 title = {mhFLIM: Resolution of heterogeneous fluorescence decays in widefield lifetime microscopy},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Algorithms,Calibration,Cell Line,Coloring Agents,Coloring Agents: chemistry,Energy-Transfer,Flim,Fluorescence,Fourier Analysis,Frequency-Domain,Humans,Imaging Microscopy,Living Cells,Microscopy,Microscopy: instrumentation,Microscopy: methods,Phase,Solutions,System,Time Factors,Tumor},
 pages = {1557-1570},
 volume = {17},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19188985,http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=000263432400044,file://localhost/Users/cfk23/Documents/Papers/2009/Schlachter/Opt Express 2009 Schlachter.pdf,papers://5b342310-4c1b-4925-bbf8-38f14091331d/Paper/p51},
 month = {1},
 day = {2},
 city = {Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1RA, England},
 id = {7e30e62c-faaf-31b1-beb4-0479345bce7d},
 created = {2010-07-07T09:21:00.000Z},
 file_attached = {true},
 profile_id = {a836303d-69f8-302f-a6cc-6bab5a6094d9},
 last_modified = {2013-11-12T12:24:30.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 abstract = {Frequency-domain fluorescence lifetime imaging microscopy (FD-FLIM) is a fast and accurate way of measuring fluorescence lifetimes in widefield microscopy. However, the resolution of multiple exponential fluorescence decays has remained beyond the reach of most practical FD-FLIM systems. In this paper we describe the implementation of FD-FLIM using a 40MHz pulse train derived from a supercontinuum source for excitation. The technique, which we term multi-harmonic FLIM (mhFLIM), makes it possible to accurately resolve biexponential decays of fluorophores without any a priori information. The system's performance is demonstrated using a mixture of spectrally similar dyes of known composition and also on a multiply-labeled biological sample. The results are compared to those obtained from time correlated single photon counting (TCSPC) microscopy and a good level of agreement is achieved. We also demonstrate the first practical application of an algorithm derived by G. Weber [1] for analysing mhFLIM data. Because it does not require nonlinear minimisation, it offers potential for realtime analysis during acquisition. (C) 2009 Optical Society of America},
 bibtype = {article},
 author = {Schlachter, S and Elder, undefined and Esposito, undefined and Kaminski, undefined and Frank, undefined and Geest, Van and Elder, a D and Esposito, A and Kaminski, G S and Frank, J H and van Geest, L K and Kaminski, C F},
 journal = {Optics Express},
 number = {3}
}

Paper  Website  abstract   bibtex   

@article{
 title = {PTSD and traumatic brain injury: folklore and fact?},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Brain Injuries,Brain Injuries: etiology,Brain Injuries: psychology,Diagnosis, Differential,Humans,Psychiatric Status Rating Scales,Stress Disorders, Post-Traumatic,Stress Disorders, Post-Traumatic: diagnosis,Stress Disorders, Post-Traumatic: psychology},
 pages = {1-5},
 volume = {22},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/18183503},
 month = {1},
 id = {906ed342-e280-33ac-99b1-a038613507db},
 created = {2017-06-01T08:23:59.557Z},
 accessed = {2012-03-09},
 file_attached = {true},
 profile_id = {b6efe121-8b29-3abc-9df5-2353a8d30e77},
 group_id = {32ad6c38-dd7d-39b9-9a71-86890e245b76},
 last_modified = {2017-06-01T08:23:59.761Z},
 tags = {anxiety,attention},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {A number of controversies and debates have arisen over the years surrounding the dual diagnosis of post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). Many of these have centred around the around the degree of protection provided by TBI against developing the disorder. The following is brief review of the literature in this area to help resolve some of these issues and to address a number of specific challenges which arise when working with this patient group.},
 bibtype = {article},
 author = {King, Nigel S},
 journal = {Brain injury : [BI]},
 number = {1}
}

@article{setakis_changes_2008,
	title = {Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib},
	volume = {59},
	issn = {0004-3591},
	doi = {10.1002/art.23925},
	abstract = {OBJECTIVE: To evaluate the impact of rofecoxib withdrawal on the characteristics of patients prescribed selective cyclooxygenase 2 (COX-2) inhibitors.
METHODS: The General Practice Research Database was used to identify patients age {\textgreater} or =18 years who were prescribed a selective COX-2 inhibitor. Various patient characteristics were noted at the start of therapy: age, sex, nonsteroidal antiinflammatory drug-related risk factors for upper gastrointestinal (GI) events, and the Framingham risk score for cardiovascular disease. Logistic regression was used to compare patients using selective COX-2 inhibitors before and after September 2004.
RESULT: The study population included 171,645 patients receiving selective COX-2 inhibitors. The number of users substantially increased over time until September 2004 and sharply declined thereafter. Approximately 80\% stopped selective COX-2 inhibitor therapy within 6 months. Patients receiving selective COX-2 inhibitors after September 2004 were younger and included more men compared with those receiving therapy before September 2004. There was no change before and after September 2004 in the proportion of patients with GI risk factors or high Framingham risk scores, after adjustment for age and sex. A correlation was found between presence of GI risk factors and high Framingham risk scores. Only 20\% of patients receiving selective COX-2 inhibitors had GI risk factors but low Framingham risk score, which did not change after September 2004.
CONCLUSION: There was no channeling in the usage of selective COX-2 inhibitors toward patients with a high risk of GI and low risk of cardiovascular disease following the withdrawal of rofecoxib.},
	language = {eng},
	number = {8},
	journal = {Arthritis and Rheumatism},
	author = {Setakis, E. and Leufkens, H. G. M. and van Staa, T. P.},
	month = aug,
	year = {2008},
	pmid = {18668614},
	keywords = {Adolescent, Adult, Aged, Cardiovascular Diseases, Cyclooxygenase 2 Inhibitors, Databases, Factual, Drug Prescriptions, Drug Utilization Review, Female, Gastrointestinal Diseases, Great Britain, Humans, Lactones, Logistic Models, Male, Middle Aged, Rheumatic Diseases, Risk Factors, Sulfones, incidence},
	pages = {1105--1111}
}

@article{haute_autorite_de_santee_has_diagnosis_2008,
	title = {[{Diagnosis} and management of {Alzheimer}'s disease and related diseases]},
	volume = {164},
	issn = {0035-3787},
	doi = {10.1016/j.neurol.2008.06.007},
	language = {fre},
	number = {8-9},
	journal = {Revue Neurologique},
	author = {{Haute Autorité de Santée (HAS)}},
	month = sep,
	year = {2008},
	pmid = {19031533},
	keywords = {Aged, Alzheimer Disease, Humans, Neurodegenerative Diseases, Neuropsychological Tests, Survival Analysis, Psychiatric Status Rating Scales, Electroencephalography, Mental Disorders, Diagnosis, Differential, Early Diagnosis, Patient Education as Topic, Terminology as Topic},
	pages = {754--774}
}

Paper  doi  abstract   bibtex   

@article{Kemp2008,
	title = {The discovery of structural form.},
	volume = {105},
	issn = {1091-6490},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2492756&tool=pmcentrez&rendertype=abstract},
	doi = {10.1073/pnas.0802631105},
	abstract = {Algorithms for finding structure in data have become increasingly important both as tools for scientific data analysis and as models of human learning, yet they suffer from a critical limitation. Scientists discover qualitatively new forms of structure in observed data: For instance, Linnaeus recognized the hierarchical organization of biological species, and Mendeleev recognized the periodic structure of the chemical elements. Analogous insights play a pivotal role in cognitive development: Children discover that object category labels can be organized into hierarchies, friendship networks are organized into cliques, and comparative relations (e.g., "bigger than" or "better than") respect a transitive order. Standard algorithms, however, can only learn structures of a single form that must be specified in advance: For instance, algorithms for hierarchical clustering create tree structures, whereas algorithms for dimensionality-reduction create low-dimensional spaces. Here, we present a computational model that learns structures of many different forms and that discovers which form is best for a given dataset. The model makes probabilistic inferences over a space of graph grammars representing trees, linear orders, multidimensional spaces, rings, dominance hierarchies, cliques, and other forms and successfully discovers the underlying structure of a variety of physical, biological, and social domains. Our approach brings structure learning methods closer to human abilities and may lead to a deeper computational understanding of cognitive development.},
	number = {31},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	author = {Kemp, Charles and Tenenbaum, Joshua B},
	month = aug,
	year = {2008},
	pmid = {18669663},
	keywords = {Algorithms, Data Interpretation, Humans, Learning, Learning: physiology, Models, Research Design, Statistical, Theoretical},
	pages = {10687--92},
}

Website  abstract   bibtex   

@article{
 title = {Interactive and cumulative effects of multiple human stressors in marine systems.},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Animals,Conservation of Natural Resources,Databases, Factual,Ecosystem,Humans,Marine Biology,Oceans and Seas,Stress, Physiological,Stress, Physiological: physiology},
 pages = {1304-15},
 volume = {11},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19046359},
 month = {12},
 id = {fa62fa47-fae0-3625-9638-9fc72fd8481e},
 created = {2013-03-13T15:07:21.000Z},
 accessed = {2012-04-07},
 file_attached = {true},
 profile_id = {e1558f6e-62d1-3c37-86bf-f78fbeac509d},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-09-13T13:45:29.603Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Crain2008},
 folder_uuids = {f143949d-9cdb-43da-b0d7-73afc391fe35},
 private_publication = {false},
 abstract = {Humans impact natural systems in a multitude of ways, yet the cumulative effect of multiple stressors on ecological communities remains largely unknown. Here we synthesized 171 studies that manipulated two or more stressors in marine and coastal systems and found that cumulative effects in individual studies were additive (26%), synergistic (36%), and antagonistic (38%). The overall interaction effect across all studies was synergistic, but interaction type varied by response level (community: antagonistic, population: synergistic), trophic level (autotrophs: antagonistic, heterotrophs: synergistic), and specific stressor pair (seven pairs additive, three pairs each synergistic and antagonistic). Addition of a third stressor changed interaction effects significantly in two-thirds of all cases and doubled the number of synergistic interactions. Given that most studies were performed in laboratories where stressor effects can be carefully isolated, these three-stressor results suggest that synergies may be quite common in nature where more than two stressors almost always coexist. While significant gaps exist in multiple stressor research, our results suggest an immediate need to account for stressor interactions in ecological studies and conservation planning.},
 bibtype = {article},
 author = {Crain, Caitlin Mullan and Kroeker, Kristy and Halpern, Benjamin S},
 journal = {Ecology letters},
 number = {12}
}

Paper  doi  abstract   bibtex   

@article{Hadjikhani2008a,
	title = {Pointing with the eyes: the role of gaze in communicating danger.},
	volume = {68},
	issn = {1090-2147},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2582139&tool=pmcentrez&rendertype=abstract},
	doi = {10.1016/j.bandc.2008.01.008},
	abstract = {Facial expression and direction of gaze are two important sources of social information, and what message each conveys may ultimately depend on how the respective information interacts in the eye of the perceiver. Direct gaze signals an interaction with the observer but averted gaze amounts to "pointing with the eyes", and in combination with a fearful facial expression may signal the presence of environmental danger. We used fMRI to examine how gaze direction influences brain processing of facial expression of fear. The combination of fearful faces and averted gazes activated areas related to gaze shifting (STS, IPS) and fear-processing (amygdala, hypothalamus, pallidum). Additional modulation of activation was observed in motion detection areas, in premotor areas and in the somatosensory cortex, bilaterally. Our results indicate that the direction of gaze prompts a process whereby the brain combines the meaning of the facial expression with the information provided by gaze direction, and in the process computes the behavioral implications for the observer.},
	number = {1},
	urldate = {2013-08-25},
	journal = {Brain and cognition},
	author = {Hadjikhani, Nouchine and Hoge, Rick and Snyder, Josh and de Gelder, Beatrice},
	month = oct,
	year = {2008},
	pmid = {18586370},
	keywords = {\#nosource, Adult, Amygdala, Amygdala: physiology, Analysis of Variance, Brain, Brain: physiology, Cerebral Cortex, Cerebral Cortex: physiology, Dominance, Cerebral, Dominance, Cerebral: physiology, Facial Expression, Fear, Fear: physiology, Female, Fixation, Ocular, Humans, Hypothalamus, Hypothalamus: physiology, Image Processing, Computer-Assisted, Image Processing, Computer-Assisted: methods, Magnetic Resonance Imaging, Magnetic Resonance Imaging: methods, Male, Pattern Recognition, Visual, Pattern Recognition, Visual: physiology, Photic Stimulation, Photic Stimulation: methods, Social Perception, Somatosensory Cortex, Somatosensory Cortex: physiology, Visual Perception, Visual Perception: physiology, Young Adult, cognitiva, humanos},
	pages = {1--8},
}

Paper  abstract   bibtex   

@article{farrant_takayasus_2008,
	title = {Takayasu's arteritis following {Crohn}'s disease in a young woman: any evidence for a common pathogenesis?},
	volume = {14},
	issn = {1007-9327},
	shorttitle = {Takayasu's arteritis following {Crohn}'s disease in a young woman},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/18609696},
	abstract = {Takayasu's arteritis and Crohn's disease are chronic inflammatory diseases of uncertain aetiology. They rarely occur together, with only twenty nine cases of co-existent Takayasu's arteritis and Crohn's disease reported in the literature. In 88\% of these cases, Takayasu's arteritis was diagnosed simultaneously or following a diagnosis of Crohn's disease. We present a case of a young Caucasian medical student, incidentally found to have bilateral carotid bruits on auscultation by a colleague. Magnetic resonance angiography revealed stenoses of the common carotid arteries with established collaterals, and a diagnosis of Type 1 Takayasu's arteritis was made. An 18(F)-fluorodeoxyglucose positron emission tomography scan revealed no active disease. Nine months later, she presented with a short history of abdominal pain, vomiting and abdominal distension. Barium follow-through and computer tomography revealed a terminal ileal stricture and proximal small bowel dilation. An extended right hemicoloectomy was performed and histopathology supported a diagnosis of Crohn's disease. This case report is presented with a particular focus on the temporal relationship between these two disease processes and explores whether their concurrence is more than just co-incidence.},
	number = {25},
	urldate = {2010-08-27},
	journal = {World Journal of Gastroenterology: WJG},
	author = {Farrant, Melissa- A L and Mason, Justin C and Wong, Newton A C S and Longman, Robert J},
	month = jul,
	year = {2008},
	pmid = {18609696},
	keywords = {Adult, Auscultation, Carotid Artery, Common, Colectomy, Collateral Circulation, Crohn Disease, Female, Humans, Incidental Findings, Magnetic Resonance Angiography, Takayasu Arteritis, Tomography, X-Ray Computed, Ultrasonography, Doppler, Color},
	pages = {4087--4090},
}

@article{iedema_national_2008,
	title = {The {National} {Open} {Disclosure} {Pilot}: evaluation of a policy implementation initiative.},
	volume = {188},
	issn = {0025-729X},
	abstract = {OBJECTIVE: To determine which aspects of open disclosure "work" for patients and health care staff, based on an evaluation of the National Open Disclosure Pilot., DESIGN, SETTING AND PARTICIPANTS: Qualitative analysis of semi-structured and open-ended interviews conducted between March and October 2007 with 131 clinical staff and 23 patients and family members who had participated in one or more open disclosure meetings. 21 of 40 pilot hospital sites, in New South Wales, South Australia, Victoria and Queensland, were included in the evaluation. Participating health care staff comprised 49 doctors, 20 nurses, and 62 managerial and support staff. In-depth qualitative data analysis involved mapping of discursive themes and subthemes across the interview transcripts., RESULTS: Interviewees broadly supported open disclosure; they expressed uncertainty about its deployment and consequences, and made detailed suggestions of ways to optimise the experience, including careful pre-planning, participation by senior medical staff, and attentiveness to consumers' experience of the adverse event., CONCLUSION: Despite some uncertainties, the national evaluation indicates strong support for open disclosure from both health care staff and consumers, as well as a need to resource this new practice.},
	number = {7},
	journal = {The Medical journal of Australia},
	author = {Iedema, Rick A M and Mallock, Nadine A and Sorensen, Roslyn J and Manias, Elizabeth and Tuckett, Anthony G and Williams, Allison F and Perrott, Bruce E and Brownhill, Suzanne H and Piper, Donella A and Hor, Suyin and Hegney, Desley G and Scheeres, Hermine B and Jorm, Christine M},
	year = {2008},
	keywords = {*Delivery of Health Care/st [Standards], *Family/px [Psychology], *Health Policy, *Hospital-Patient Relations, *Interviews as Topic, *Patient Satisfaction, *Personnel, Hospital, *Truth Disclosure, Australia, humans},
	pages = {397--400},
}

@Article{Elliot2007,
  author   = {Andrew J Elliot and Markus A Maier and Arlen C Moller and Ron Friedman and J\"org Meinhardt},
  journal  = {J Exp Psychol Gen},
  title    = {Color and psychological functioning: the effect of red on performance attainment.},
  year     = {2007},
  number   = {1},
  pages    = {154-68},
  volume   = {136},
  abstract = {This research focuses on the relation between color and psychological
	functioning, specifically, that between red and performance attainment.
	Red is hypothesized to impair performance on achievement tasks, because
	red is associated with the danger of failure in achievement contexts
	and evokes avoidance motivation. Four experiments demonstrate that
	the brief perception of red prior to an important test (e.g., an
	IQ test) impairs performance, and this effect appears to take place
	outside of participants' conscious awareness. Two further experiments
	establish the link between red and avoidance motivation as indicated
	by behavioral (i.e., task choice) and psychophysiological (i.e.,
	cortical activation) measures. The findings suggest that care must
	be taken in how red is used in achievement contexts and illustrate
	how color can act as a subtle environmental cue that has important
	influences on behavior.},
  doi      = {10.1037/0096-3445.136.1.154},
  keywords = {Achievement, Adolescent, Adult, Color Perception, Escape Reaction, Female, Humans, Male, Psychology, 17324089},
}

Paper  abstract   bibtex   

@article{bidwell_testing_2007,
	title = {Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder.},
	volume = {62},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2687149&tool=pmcentrez&rendertype=abstract},
	abstract = {BACKGROUND: Neurocognitive deficits associated with attention-deficit/hyperactivity disorder (ADHD) might be useful intermediate endophenotypes for determining specific genetic pathways that contribute to ADHD. METHODS: This study administered 17 measures from prominent neuropsychological theories of ADHD (executive function, processing speed, arousal regulation and, motivation/delay aversion) in dizygotic (DZ) twin pairs discordant for ADHD and control twin pairs (ages 8-18 years) to compare performance between twins affected with ADHD (n = 266), their unaffected co-twins (n = 228), and control children from twin pairs without ADHD or learning difficulties (n = 332). RESULTS: The ADHD subjects show significant impairment on executive function, processing speed, and response variability measures compared with control subjects. Unaffected co-twins of ADHD subjects are significantly impaired on nearly all the same measures as their ADHD siblings, even when subclinical symptoms of ADHD are controlled. CONCLUSIONS: Executive function, processing speed, and response variability deficits might be useful endophenotypes for genetic studies of ADHD.},
	number = {9},
	journal = {Biological Psychiatry},
	author = {Bidwell, L Cinnamon and Willcutt, Erik G and Defries, John C and Pennington, Bruce F},
	year = {2007},
	note = {Publisher: Department of Psychology, University of Colorado, Boulder, Colorado, USA. lcb@colorado.edu},
	keywords = {adolescent, analysis variance, attention deficit disorder with hyperactivity, attention deficit disorder with hyperactivity gen, attention deficit disorder with hyperactivity phy, child, cognition disorders, cognition disorders genetics, cognition disorders physiopathology, diseases twins, diseases twins genetics, diseases twins psychology, female, genetic predisposition disease, genetic predisposition disease genetics, humans, intelligence tests, male, neuropsychological tests, neuropsychological tests statistics \& numerical d, phenotype, problem solving, reading, sex factors, twins},
	pages = {991--998},
}

Website  abstract   bibtex   

@article{
 title = {No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Adult,Apolipoproteins E/*genetics,Cell Adhesion Molecules/*genetics,Disease Progression,Female,Gene Frequency,Genotype,Humans,Male,Middle Aged,Multiple Sclerosis/*genetics/physiopathology,Severity of Illness Index},
 pages = {156-160},
 volume = {186},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17376543},
 edition = {2007/03/23},
 id = {97823616-1f4d-37f6-a788-8ec55f360a74},
 created = {2017-06-19T13:43:25.441Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:25.558Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Ramagopalan, S V<m:linebreak/>Deluca, G C<m:linebreak/>Morrison, K M<m:linebreak/>Herrera, B M<m:linebreak/>Dyment, D A<m:linebreak/>Orton, S<m:linebreak/>Bihoreau, M T<m:linebreak/>Degenhardt, A<m:linebreak/>Pugliatti, M<m:linebreak/>Sadovnick, A D<m:linebreak/>Sotgiu, S<m:linebreak/>Ebers, G C<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>Netherlands<m:linebreak/>Journal of neuroimmunology<m:linebreak/>S0165-5728(07)00061-6<m:linebreak/>J Neuroimmunol. 2007 May;186(1-2):156-60. Epub 2007 Mar 21.</m:note>},
 abstract = {Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. Apolipoprotein E (APOE) is involved in neuronal remodelling and several studies have attempted to examine the effect of APOE on MS disease severity, but its function in modifying the course of MS is controversial. It has been suggested recently that PVRL2, not APOE, is the locus on chromosome 19 which influences clinical outcome of MS. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of APOE and PVRL2 on MS disease severity. The MS cases selected represent the prognostic best 5% (benign MS) and worst 5% (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that APOE or PVRL2 have any outcome modifying activity. We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS.},
 bibtype = {article},
 author = {Ramagopalan, S V and Deluca, G C and Morrison, K M and Herrera, B M and Dyment, D A and Orton, S and Bihoreau, M T and Degenhardt, A and Pugliatti, M and Sadovnick, A D and Sotgiu, S and Ebers, G C},
 journal = {J Neuroimmunol},
 number = {1-2}
}

@article{gentilini_is_2007,
	title = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours? {Lessons} from a series in a single institution},
	volume = {18},
	issn = {0923-7534},
	shorttitle = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours?},
	doi = {10.1093/annonc/mdm182},
	abstract = {BACKGROUND: Current guidelines for post-mastectomy radiotherapy (PMRT) derive largely from extrapolating information from multicentre trials. The aim of this study was to describe outcomes of patients who underwent mastectomy without radiotherapy in a single institution.
PATIENTS AND METHODS: 650 patients had total mastectomy and axillary dissection without PMRT between 1997 and 2001. Median follow-up was 65 months.
RESULTS: 5-year cumulative incidence of loco-regional recurrence (LRR) was 6.8\% (3.0, 8.1, 9.9\% in node negative, 1-3, {\textgreater} or =4 positive nodes, respectively). At the multivariate analysis, positive lymph nodes and endocrine non-responsive tumours were found to shorten LRR disease-free survival. In patients with positive hormone receptors, 5-year cumulative incidence of LRR disease-free survival were 2.3\%, 7.6\% and 7.6\% for node negative, 1-3 and {\textgreater} or =4 positive lymph nodes, respectively. The same figures were 5.9\%, 10.3\% and 20.0\% in patients with endocrine non-responsive tumours.
CONCLUSIONS: patients with endocrine-responsive tumours treated by mastectomy and complete (level III) axillary dissection have a low risk of LRR even if four or more positive lymph nodes are involved, thus giving rise to doubts on the use of PMRT in this subset of patients. On the other hand, PMRT might play a role for patients with negative hormone receptors and four or more positive nodes.},
	language = {eng},
	number = {8},
	journal = {Annals of oncology: official journal of the European Society for Medical Oncology / ESMO},
	author = {Gentilini, O and Botteri, E and Rotmensz, N and Intra, M and Gatti, G and Silva, L and Peradze, N and Sahium, R C and Gil, L B and Luini, A and Veronesi, P and Galimberti, V and Gandini, S and Goldhirsh, A and Veronesi, U},
	month = aug,
	year = {2007},
	pmid = {17693648},
	keywords = {Adult, Axilla, Breast Neoplasms, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Lymph Node Excision, mastectomy, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, Adjuvant, Retrospective Studies, Treatment Outcome},
	pages = {1342--1347},
	file = {Ann Oncol-2007-Gentilini-1342-7.pdf:files/46589/Ann Oncol-2007-Gentilini-1342-7.pdf:application/pdf}
}

Paper  doi  abstract   bibtex   

@article{Gunaratnam2007,
	title = {Mechanism of acridine-based telomerase inhibition and telomere shortening.},
	volume = {74},
	issn = {1873-2968},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/17631279},
	doi = {10.1016/j.bcp.2007.06.011},
	abstract = {The trisubstituted acridine compound BRACO-19 has been developed as a ligand for stabilising G-quadruplex structures. It is shown here that BRACO-19 produces short- and long-term growth arrest in cancer cell lines, and is significantly less potent in a normal cell line. BRACO-19 reduces telomerase activity and long-term telomere length attrition is observed. It is also shown that BRACO-19 binds to telomeric single-stranded overhang DNA, consistent with quadruplex formation, and the single-stranded protein hPOT1 has been shown to be displaced from the overhang in vitro and in cellular experiments. It is concluded that the cellular activity of BRACO-19 can be ascribed both to the uncapping of 3' telomere ends and to telomere shortening that may preferentially affect cells with short telomeres.},
	number = {5},
	journal = {Biochemical pharmacology},
	author = {Gunaratnam, Mekala and Greciano, Olga and Martins, Cristina and Reszka, Anthony P and Schultes, Christoph M and Morjani, Hamid and Riou, Jean-Francois and Neidle, Stephen},
	month = oct,
	year = {2007},
	pmid = {17631279},
	keywords = {\#nosource, Acridines, Acridines: chemistry, Acridines: pharmacology, Antineoplastic Agents, Antineoplastic Agents: chemistry, Antineoplastic Agents: pharmacology, Cell Line, Dose-Response Relationship, Drug, Humans, Molecular Structure, Telomerase, Telomerase: antagonists \& inhibitors, Telomere, Telomere: metabolism, g-quadruplex ligands},
	pages = {679--89},
}

Website  bibtex   

@article{
 title = {Point/Counterpoint. Proton therapy is the best radiation treatment modality for prostate cancer},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Clinical Trials as Topic/*trends,Humans,Male,Physician's Practice Patterns/*trends,Prostatic Neoplasms/*epidemiology/*radiotherapy,Protons/adverse effects/*therapeutic use,Radiation Injuries/etiology/prevention & control,Radiotherapy, Conformal/adverse effects/*methods,Risk Assessment},
 pages = {375-378},
 volume = {34},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17388153},
 edition = {2007/03/29},
 id = {b0987504-2aa6-3424-93bc-d7edc6cc3f82},
 created = {2017-06-19T13:43:25.395Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:25.490Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Moyers, Michael F<m:linebreak/>Pouliot, Jean<m:linebreak/>Orton, Colin G<m:linebreak/>United States<m:linebreak/>Medical physics<m:linebreak/>Med Phys. 2007 Feb;34(2):375-8.</m:note>},
 bibtype = {article},
 author = {Moyers, M F and Pouliot, J and Orton, C G},
 journal = {Med Phys},
 number = {2}
}

@Article{Kovacs_2006_9144,
  author = {Kovacs, L. and Yassouridis, A. and Zimmermann, A. and Brockmann, G. and Wohnl, A. and Blaschke, M. and Eder, M. and Schwenzer-Zimmerer, K. and Rosenberg, R. and Papadopulos, N. A. and Biemer, E.},
 journal = {Annals of Plastic Surgery},
 number = {3},
 pages = {229-236},
 title = {Optimization of 3-dimensional imaging of the breast region with 3-dimensional laser scanners},
 volume = {56},
 year = {2006},
 keywords = {Breast/*anatomy, &, histology, Female, Humans, *Image, Processing, Computer-Assisted, Imaging, Three-Dimensional/*instrumentation, Lasers/diagnostic, use, Manikins, Phantoms, Imaging, Sensitivity, and, Specificity},
 title_with_no_special_chars = {Optimization of 3dimensional imaging of the breast region with 3dimensional laser scanners}
}

@article{fox_prevalence_2006,
	title = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database: {A} series of retrospective analyses of data from 1998 through 2002},
	volume = {28},
	issn = {0149-2918},
	shorttitle = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database},
	doi = {10.1016/j.clinthera.2006.03.005},
	abstract = {BACKGROUND: Since the mid-1990s, the development of new oral antidiabetic agents (OAs) and treatment guidelines have created an opportunity to improve glycemic control in patients with type 2 diabetes.
OBJECTIVES: This study aimed to assess the prevalence of good and inadequate glycemic control across a 5-year period among patients with diabetes in the United Kingdom. It also investigated the factors associated with achieving glycemic targets.
METHODS: This was a retrospective, cross-sectional analysis of data from the General Practice Research Database. Three limits were used to assess glycosylated hemoglobin (HbA1c): 6.5\%, 7.0\%, or 7.5\%. Values above the cutoffs indicated inadequate control of HbA1c; those at or below the cutoffs indicated good control. The study evaluated clinical and pharmacy data from the years 1998 to 2002 for patients with type 2 diabetes, {\textgreater} or =2 years of follow-up, and {\textgreater} or =2 HbA1c measurements during the first year. Five independent cross-sectional analyses were conducted, grouping data by year. Statistical significance was determined by Student t and chi2 tests.
RESULTS: Data were analyzed for 10,663 patients aged 17 to 98 years. The number of total eligible type 2 diabetes patients increased over the course of the study period: 5674 patients in 1998, 6553 in 1999, 7314 in 2000, 7323 in 2001, and 6192 in 2002. Overall, the study population had a mean (SD) age of 66 (11.0) years, was 53\% male (3033/5674), and had a body mass index of 29 kg/m(2). Seventy-six percent of patients had HbA1c {\textgreater}7.0\% and 37\% were taking {\textgreater} or =2 oral agents. In 1998 and 2002, 79\% (4482/5674) and 76\% (4732/6192) of patients, respectively, had inadequate glycemic control, defined as HbA1c {\textgreater}7.0\%. When defined as HbA1c {\textgreater}7.5\%, 69\% (3923/5674) and 62\% (3814/6192) of patients, respectively, had inadequate control. Finally, when defined as HbA1c {\textgreater}6.5\%, 88\% (5011/5674) of patients in both 1998 and 2002 had inadequate control. Compared with patients with good disease control (HbA1c {\textless} or =7.0\%), patients with inadequate control were approximately 2 years younger (P {\textless} 0.001) and had been prescribed more OAs: 41\% received {\textgreater} or =2 OAs in 1998 and 52\% in 2002, compared with 23\% and 34\% (both, P = 0.001), respectively, of patients with good glycemic control (P {\textless} 0.02). Sex, number of diabetes complications, and number of comorbidities did not differ between groups (P = NS).
CONCLUSIONS: Despite the introduction of new OAs and treatment guidelines, the prevalence of inadequate glycemic control remains high ({\textgreater}60\%) in patients with type 2 diabetes in the United Kingdom. Regardless of the HbA1c cutoff, patients with inadequate control were younger and received prescriptions for more OAs than patients with good control.},
	language = {eng},
	number = {3},
	journal = {Clinical Therapeutics},
	author = {Fox, Kathleen M. and Gerber Pharmd, Robert A. and Bolinder, Bjorn and Chen, Jack and Kumar, Sanjaya},
	month = mar,
	year = {2006},
	pmid = {16750453},
	keywords = {Administration, Oral, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Family Practice, Female, Great Britain, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Retrospective Studies, databases as topic},
	pages = {388--395}
}

@article{ hommet_idiopathic_2006,
  title = {Idiopathic epileptic syndromes and cognition},
  volume = {30},
  issn = {0149-7634},
  doi = {10.1016/j.neubiorev.2005.06.004},
  abstract = {Epilepsy is frequently associated with cognitive impairments which result from various interacting factors. The present paper deals with the contribution of neuropsychology to the characterization of the type of epilepsy and the possible mechanisms underlying idiopathic epileptic syndromes. The non-lesional, so-called idiopathic epilepsies, constitute an interesting model for assessing the relationship between epileptiform {EEG} discharges and cognition. Among the idiopathic generalized epilepsies, disorders of social integration and personality have been frequently reported in juvenile myoclonic epilepsy ({JME}). Since similar disturbances are observed in frontal-lobe-lesioned patients, impairments in other frontal lobe functions (e.g. executive functions) might be expected in {JME}. This gives rise to speculation about the possible underlying pathophysiological mechanisms in {JME}. With regard to partial idiopathic epilepsies, benign childhood epilepsy with centrotemporal spikes ({BCECTS}) may provide a useful model for the study of the relationship between epileptiform {EEG} discharges in the peri-sylvian region and language functions. Furthermore, the description of mild cognitive dysfunctions in {BCECTS}, and their persistence into adulthood, can provide information about compensatory mechanisms and may allow for the generation of remedial strategies. Thus, 'lesional' neuropsychology has given way to 'dynamic' neuropsychology based on specific postulates. By using the cognitive profile to specify the mechanism underlying the behavioral disturbances observed in different types of epilepsy, neuropsychology may eventually contribute to a revision of the present classification of epileptic syndromes. In addition, the neuropsychological data may help predict the extent and limits of functional recovery and cerebral plasticity.},
  language = {eng},
  number = {1},
  journal = {Neuroscience and Biobehavioral Reviews},
  author = {Hommet, Caroline and Sauerwein, Hannelore C. and De Toffol, Bertrand and Lassonde, Maryse},
  year = {2006},
  pmid = {16120462},
  keywords = {Cognition Disorders, Electroencephalography, Epilepsy, Humans, Neuropsychology, Syndrome},
  pages = {85--96}
}

Paper  bibtex   

@article{
 id = {d14cb890-55c2-3ae7-867b-c26ce0888855},
 title = {Deadspace: invasive or not?},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Breath Tests,Breath Tests: methods,Capnography,Carbon Dioxide,Carbon Dioxide: analysis,Humans,Respiratory Dead Space,Respiratory Distress Syndrome, Adult,Respiratory Distress Syndrome, Adult: physiopathol},
 created = {2009-07-23T22:42:16.000Z},
 pages = {4-7},
 volume = {96},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16357115},
 month = {1},
 file_attached = {true},
 profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
 group_id = {f87494e7-529d-3e68-b1f1-0e6d57d138db},
 last_modified = {2014-07-19T19:15:28.000Z},
 read = {false},
 starred = {true},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Drummond2006},
 client_data = {"desktop_id":"3003a2ac-bf9a-4502-9b9f-c80e15e72d57"},
 bibtype = {article},
 author = {Drummond, G B and Fletcher, R},
 journal = {British journal of anaesthesia},
 number = {1}
}

Paper  doi  abstract   bibtex   

@article{rosenbaum_cinderella_2005,
	title = {The {Cinderella} of psychology: the neglect of motor control in the science of mental life and behavior},
	volume = {60},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15943523},
	doi = {10/fnb7t2},
	abstract = {One would expect psychology--the science of mental life and behavior--to place great emphasis on the means by which mental life is behaviorally expressed. Surprisingly, however, the study of how decisions are enacted--the focus of motor control research--has received little attention in psychology. This article documents the neglect and considers possible reasons for it. The hypotheses considered include three that are raised and then rejected: (a) no famous psychologists have studied motor control, (b) cognitive psychologists are mainly interested in uniquely human functions, and (c) motor control is simply too hard to study. Three other hypotheses are more viable: (d) cognitive psychologists have been more interested in epistemology than in action, (e) psychologists have disfavored motor control because overt responses were the only admissible measure in behaviorism, and (f) psychologists have felt that neuroscientists have the market cornered when it comes to motor control research. There are signs that motor control's Cinderella status is changing.},
	number = {4},
	journal = {Am Psychol},
	author = {Rosenbaum, D.A.},
	year = {2005},
	keywords = {\#nosource, *Cognition, *Psychological Theory, *Psychomotor Performance, *Social Behavior, Humans, Psychology/*trends},
	pages = {308--17},
}

@article{frank_effects_2005,
	title = {Effects of compulsory treatment orders on time to hospital readmission},
	volume = {56},
	issn = {1075-2730},
	doi = {10.1176/appi.ps.56.7.867},
	abstract = {To evaluate the effect of compulsory community treatment orders on subsequent time out of the hospital, the authors studied the admission dates of psychotic patients who had repeated hospitalizations in Quebec, Canada, and divided each admission according to its time in relation to the index admission, during which the judicial order was obtained. The data were stratified by type of admission (early, preindex, index, or postindex), and the hypothesis tested was that the median time to readmission would be greatest for the index admission. The hypothesis was confirmed, supporting previous findings that judicial orders that mandate severely ill psychotic patients to undergo compulsory community treatment are associated with decreased time spent in the hospital and thus increased personal freedom.},
	language = {eng},
	number = {7},
	journal = {Psychiatric Services (Washington, D.C.)},
	author = {Frank, Daniel and Perry, J. Christopher and Kean, Dana and Sigman, Maxine and Geagea, Khalil},
	month = jul,
	year = {2005},
	pmid = {16020822},
	keywords = {Adult, Aged, Aged, 80 and over, Commitment of Mentally Ill, Community Mental Health Services, Female, Follow-Up Studies, Hospitalization, Humans, Male, Mental Disorders, Middle Aged, Patient Admission, Quebec, Time Factors, Treatment Outcome},
	pages = {867--869},
}

Paper  doi  abstract   bibtex   

@article{Karniel2005,
	title = {Computational analysis in vitro: dynamics and plasticity of a neuro-robotic system.},
	volume = {2},
	issn = {1741-2560},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/16135888},
	doi = {10.1088/1741-2560/2/3/S08},
	abstract = {When the brain interacts with the environment it constantly adapts by representing the environment in a form that is called an internal model. The neurobiological basis for internal models is provided by the connectivity and the dynamical properties of neurons. Thus, the interactions between neural tissues and external devices provide a fundamental means for investigating the connectivity and dynamical properties of neural populations. We developed this idea, suggested in the 1980s by Valentino Braitenberg, for investigating and representing the dynamical behavior of neuronal populations in the brainstem of the lamprey. The brainstem was maintained in vitro and connected in a closed loop with two types of artificial device: (a) a simulated dynamical system and (b) a small mobile robot. In both cases, the device was controlled by recorded extracellular signals and its output was translated into electrical stimuli delivered to the neural system. The goal of the first study was to estimate the dynamical dimension of neural preparation in a single-input/single-output configuration. The dynamical dimension is the number of state variables that together with the applied input determine the output of a system. The results indicate that while this neural system has significant dynamical properties, its effective complexity, as established by the dynamical dimension, is rather moderate. In the second study, we considered a more specific situation, in which the same portion of the nervous system controls a robotic device in a two-input/two-output configuration. We fitted the input-output data from the neuro-robotic preparation to neural network models having different internal dynamics and we observed the generalization error of each model. Consistent with the first study, this second experiment showed that a simple recurrent dynamical model was able to capture the behavior of the hybrid system. This experimental and computational framework provides the means for investigating neural plasticity and internal representations in the context of brain-machine interfaces.},
	number = {3},
	urldate = {2012-07-20},
	journal = {J. Neural Eng.},
	author = {Karniel, Amir and Kositsky, Michael and Fleming, Karen M and Chiappalone, Michela and Sanguineti, Vittorio and Alford, Simon T and Mussa-Ivaldi, Ferdinando a},
	month = sep,
	year = {2005},
	pmid = {16135888},
	keywords = {Animals, Brain, Brain: physiology, Cybernetics, Cybernetics: methods, Humans, Lampreys, Man-Machine Systems, Models, Nerve Net, Nerve Net: physiology, Neurological, Neuronal Plasticity, Neuronal Plasticity: physiology, Robotics, Robotics: methods, User-Computer Interface},
	pages = {S250--65},
}

Paper  doi  abstract   bibtex   

@article{mazard_neural_2005,
	title = {Neural impact of the semantic content of visual mental images and visual percepts},
	volume = {24},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16099355},
	doi = {10/cwgtzc},
	abstract = {The existence of hemispheric lateralization of visual mental imagery remains controversial. In light of the literature, we used fMRI to test whether processing of mental images of object drawings preferentially engages the left hemisphere to compared non-object drawings. An equivalent comparison was also made while participants actually perceived object and non-object drawings. Although these two conditions engaged both hemispheres, activation was significantly stronger in the left occipito-temporo-frontal network during mental inspection of object than of non-object drawings. This network was also activated when perception of object drawings was compared to that of non-object drawings. An interaction was nonetheless observed: this effect was stronger during imagery than during perception in the left inferior frontal and the left inferior temporal gyrus. Although the tasks subjects performed did not explicitly require semantic analysis, activation of this network probably reflected, at least in part, a semantic and possibly a verbal retrieval component when object drawings were processed. Mental imagery tasks elicited activation of early visual cortex at a lower level than perception tasks. In the context of the imagery debate, these findings indicate that, as previously suggested, figurative imagery could involve primary visual cortex and adjacent areas.},
	number = {3},
	journal = {Brain Res Cogn Brain Res},
	author = {Mazard, A. and Laou, L. and Joliot, M. and Mellet, E.},
	year = {2005},
	keywords = {\#nosource, Adolescent, Adult, Cerebral Cortex/*physiology, Data Interpretation, Statistical, Female, Functional Laterality/physiology, Humans, Image Processing, Computer-Assisted, Imagination/*physiology, Learning/physiology, Magnetic Resonance Imaging, Male, Memory/*physiology, Nerve Net/physiology, Photic Stimulation, Semantics, Visual Cortex/physiology, Visual Perception/*physiology},
	pages = {423--35},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Biological evidence for inheritance of exceptional longevity},
 type = {article},
 year = {2005},
 identifiers = {[object Object]},
 keywords = {Age Factors,Aged,Aged, 80 and over,Aging/*ethnology/*genetics,Alleles,Carrier Proteins/genetics,Case-Control Studies,Genotype,Glycoproteins/genetics,Homozygote,Humans,Lipids/metabolism,Lipoproteins, HDL/genetics/metabolism,Lipoproteins, LDL/genetics/metabolism,Longevity/*genetics,Phenotype,Polymorphism, Genetic,Valine/genetics},
 pages = {341-345},
 volume = {126},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15621216},
 id = {ac53ce7e-fc6c-35da-8438-be74b645fce9},
 created = {2017-06-19T13:45:30.857Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:45:31.024Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0047-6374<m:linebreak/>Journal Article</m:note>},
 abstract = {Subjects with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility. In a case control study, we aim to determine phenotype and genotype of exceptional longevity in a genetically homogenous population (Ashkenazi Jews), and their offspring, while an age-matched control group of Ashkenazi Jews was used as control groups. We demonstrated that exceptional longevity and healthy aging in humans is an inherited phenotype across three generations. Moreover, we demonstrated that subjects with exceptional longevity and their offspring have significantly larger high-density lipoprotein (HDL) levels and particle sizes and low-density lipoprotein (LDL) levels that reflect on their health and cognitive function performance. This phenotype have led us to study candidate genes involved in lipoprotein metabolism, and to the implication of homozygosity for the 405 valine (V) allele of cholesteryl ester transfer protein (CETP). A markedly higher frequency of a functional CETP variant that led to increased particle sizes of HDL and LDL and thus a better health performance is the first example of a phenotype and an associated genotype in humans with exceptional longevity. Hopefully, this line of research will lead us to establish which genotype is necessary (although not necessary sufficient) for a prolonged disease-free aging.},
 bibtype = {article},
 author = {Atzmon, G and Rincon, M and Rabizadeh, P and Barzilai, N},
 journal = {Mech Ageing Dev},
 number = {2}
}

@Article{Szenkovits2005,
  author   = {Gayaneh Szenkovits and Franck Ramus},
  journal  = {Dyslexia},
  title    = {Exploring dyslexics' phonological deficit {I}: lexical vs sub-lexical and input vs output processes.},
  year     = {2005},
  number   = {4},
  pages    = {253-68},
  volume   = {11},
  abstract = {We report a series of experiments designed to explore the locus of
	the phonological deficit in dyslexia. Phonological processing of
	dyslexic adults is compared to that of age- and IQ-matched controls.
	Dyslexics' impaired performance on tasks involving nonwords suggests
	that sub-lexical phonological representations are deficient. Contrasting
	nonword repetition vs auditory nonword discrimination suggests that
	dyslexics are specifically impaired in input phonological processing.
	These data are compatible with the hypothesis that the deficit initially
	affects input sub-lexical processes, and further spreads to output
	and lexical processes in the course of language acquisition. Further
	longitudinal research is required to confirm this scenario as well
	as to tease apart the role of the quality of phonological representations
	from that of verbal short-term memory processes.},
  keywords = {Adult, Dyslexia, Female, Humans, Male, Memory, Phonetics, Vocabulary, 16355747},
}

Website  abstract   bibtex   

@article{
 title = {A history of total mercury in edible muscle of fish from lakes in northern Canada.},
 type = {article},
 year = {2005},
 identifiers = {[object Object]},
 keywords = {Animals,Canada,Environmental Monitoring,Fishes,Food Contamination,Fresh Water,Geological Phenomena,Geology,Humans,Mercury,Mercury: analysis,Mercury: standards,Muscles,Muscles: chemistry,Risk Assessment,Water Pollutants, Chemical,Water Pollutants, Chemical: analysis,Water Pollutants, Chemical: standards},
 pages = {427-63},
 volume = {351-352},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16169059},
 month = {12},
 day = {1},
 id = {5871338c-f5be-3a03-8357-10e95e527458},
 created = {2012-01-11T20:00:37.000Z},
 accessed = {2011-10-01},
 file_attached = {true},
 profile_id = {1f6a330f-f6a3-36e6-abae-0954f070a071},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Lockhart2005a},
 private_publication = {false},
 abstract = {Subsistence fishing has been an important source of food for Native People in northern Canada since prehistoric time. Measurements of the levels of mercury in edible muscle of northern fish have been undertaken for over three decades in efforts to evaluate the risks of consuming northern fish. This report summarizes the data obtained from 7974 fish of 25 species from sites distributed from the Yukon to Labrador. The most abundant species were lake trout, lake whitefish, arctic char, walleye, northern pike and burbot. The question being asked was essentially "Are the fish safe to eat?" The results were used to support decisions on fishing and consumption of fish. They were sorted in several ways, into concentration ranges corresponding to human consumption guidelines, into political jurisdictions and into types of bedrock geology. Overall walleye, northern pike and lake trout, usually exceeded the subsistence consumption guideline of 0.2 microg g-1 total mercury and often exceeded the higher guideline of 0.5 microg g-1 total mercury for commercial sales of fish. Mercury in burbot, another facultative predator, was often lower but several still exceeding a guideline. Arctic char collections were mostly from anadromous populations and these had very low levels of mercury, presumably reflecting marine food sources. Lake whitefish were among the cleanest fish examined with 69 of 81 collections falling in the lowest range. Most collections were from sites in sedimentary rock. However a few sites were in metamorphic, intrusive or volcanic rocks and these, taken together, tended to have a higher proportion of sites in the higher ranges of mercury. These results indicate a widespread problem with mercury in subsistence fisheries for predator species of fish with the problem being most problematic for Nunavut.},
 bibtype = {article},
 author = {Lockhart, W L and Stern, G a and Low, G and Hendzel, M and Boila, G and Roach, P and Evans, M S and Billeck, B N and DeLaronde, J and Friesen, S and Kidd, K and Atkins, S and Muir, D C G and Stoddart, M and Stephens, G and Stephenson, S and Harbicht, S and Snowshoe, N and Grey, B and Thompson, S and DeGraff, N},
 journal = {The Science of the total environment}
}

Paper  abstract   bibtex   

@article{riva_use_2003,
	title = {The use of the internet in psychological research: comparison of online and offline questionnaires.},
	volume = {6},
	issn = {1094-9313},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/12650565},
	abstract = {The Internet can be an effective medium for the posting, exchange, and collection of information in psychology-related research and data. The relative ease and inexpensiveness of creating and maintaining Web-based applications, associated with the simplicity of use via the graphic-user interface format of form-based surveys, can establish a new research frontier for the social and behavioral sciences. To explore the possible use of Internet tools in psychological research, this study compared Web-based assessment techniques with traditional paper-based methods of different measures of Internet attitudes and behaviors in an Italian sample. The collected data were analyzed to identify both differences between the two samples and in the psychometric characteristics of the questionnaires. Even if we found significant differences between the two samples in the Internet attitudes and behaviors, no relevant differences were found in the psychometric properties of the different questionnaires. This result, similar to the ones previously obtained in Web-based assessments of personality constructs, is even more interesting given the lack of control on the characteristics of the online sample. These finding suggests that, if sampling control and validity assessment is provided, Internet-based questionnaires can be a suitable alternative to more traditional paper-based measures.},
	number = {1},
	urldate = {2012-07-29},
	journal = {Cyberpsychology \& behavior : the impact of the Internet, multimedia and virtual reality on behavior and society},
	author = {Riva, Giuseppe and Teruzzi, Tiziana and Anolli, Luigi},
	month = feb,
	year = {2003},
	keywords = {Adolescent, Adult, Female, Humans, Internet, Male, Psychology, Psychology: instrumentation, Psychometrics, Psychometrics: instrumentation, Questionnaires, Research, Research: instrumentation},
	pages = {73--80},
}

@article{witczak_thio-sugars_2003,
	title = {Thio-sugars {VII}. {Effect} of 3-deoxy-4-{S}-(beta-{D}-gluco- and beta-{D}-galactopyranosyl)-4-thiodisaccharides and their sulfoxides and sulfones on the viability and growth of selected murine and human tumor cell lines},
	volume = {338},
	issn = {0008-6215},
	abstract = {The first conversion of (1--{\textgreater}4)-thiodisaccharides into corresponding sulfoxides and sulfones by conventional oxidation with m-chloroperoxybenzoic acid (MCPBA) is reported. The effects of alpha-(1--{\textgreater}4)-3'-deoxythiodisaccharides (8-9) and their sulfoxide (14-15) and sulfone (16-17) derivatives on murine leukemia and human colon and pancreatic carcinoma cell viability were studied. Concentrations of thio-sugars that decreased tumor cell line viability by 50\% (IC(50)), measured via the MTT assay, ranged from 6.4 to 38.3 microg/mL. The effect of alpha-(1--{\textgreater}4)-3'-deoxythiodisaccharide derivatives were most profound on human pancreatic epithelial carcinoma (PANC-1) cells with compounds 8 and 9 having IC(50) values of 6.4 microg/mL and 8.2 microg/mL, respectively. Sulfone derivatives 16 and 17 also had pronounced effects on PANC-1 cell viability (IC(50)=10.2 microg/mL and 9.6 microg/mL, respectively). These results indicate that deoxythio-disaccharide analogs generated by functionalization of the universal chiral precursor levoglucosenone may have cytotoxic properties and therapeutic potential as anticancer agents.},
	language = {eng},
	number = {1},
	journal = {Carbohydrate Research},
	author = {Witczak, Zbigniew J. and Kaplon, Peter and Dey, P. Markus},
	month = jan,
	year = {2003},
	pmid = {12504376},
	keywords = {Animals, Antineoplastic Agents, Carbohydrates, Cell Division, Cell Survival, Humans, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Sulfhydryl Compounds, Sulfones, Sulfoxides, Tumor Cells, Cultured},
	pages = {11--18},
}

@article{chetkovich_postsynaptic_2002,
	title = {Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms},
	volume = {22},
	issn = {1529-2401},
	doi = {20026598},
	abstract = {Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs including PDZ (postsynaptic density-95/Discs large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and plasticity at excitatory synapses. We report that N-terminal alternative splicing of PSD95 generates an isoform, PSD95beta that contains an additional "L27" motif, which is also present in SAP97. Using yeast two hybrid and coimmunoprecipitation assays, we demonstrate that this N-terminal L27 domain of PSD-95beta, binds to an L27 domain in the membrane-associated guanylate kinase calcium/calmodulin-dependent serine kinase, and to Hrs, an endosomal ATPase that regulates vesicular trafficking. By transfecting heterologous cells and hippocampal neurons, we find that interactions with the L27 domain regulate synaptic clustering of PSD95beta. Disrupting Hrs-regulated early endosomal sorting in hippocampal neurons selectively blocks synaptic clustering of PSD95beta but does not interfere with trafficking of the palmitoylated isoform, PSD95alpha. These studies identify molecular and functional heterogeneity in synaptic PSD95 complexes and reveal critical roles for L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering.},
	language = {eng},
	number = {15},
	journal = {The Journal of Neuroscience: The Official Journal of the Society for Neuroscience},
	author = {Chetkovich, Dane M. and Bunn, Robert C. and Kuo, Sheng-Han and Kawasaki, Yoshimi and Kohwi, Minoree and Bredt, David S.},
	month = aug,
	year = {2002},
	pmid = {12151521},
	pmcid = {PMC6758133},
	keywords = {Adaptor Proteins, Signal Transducing, Alternative Splicing, Amino Acid Motifs, Animals, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cells, Cultured, Disks Large Homolog 4 Protein, Endosomal Sorting Complexes Required for Transport, Guanylate Kinases, Humans, Intracellular Signaling Peptides and Proteins, Macromolecular Substances, Membrane Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Nucleoside-Phosphate Kinase, Phosphoproteins, Precipitin Tests, Protein Isoforms, Protein Structure, Tertiary, Protein Transport, Rats, Rodentia, Sequence Homology, Amino Acid, Synapses, Two-Hybrid System Techniques},
	pages = {6415--6425},
}

@Article{Ridker_2002_1393,
  author = {Ridker, P.M. and Rifai, N. and Rose, L. and Buring, J.E. and Cook, N.R.},
 journal = {New England Journal of Medicine},
 note = {Hl-43851/hl/nhlbi Hl-58755/hl/nhlbi Hl-63293/hl/nhlbi Comparative Study Evaluation Studies Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States},
 number = {20},
 pages = {1557-1565},
 title = {Comparison of {C}-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events},
 volume = {347},
 year = {2002},
 keywords = {Aged, Biological, Markers/blood, C-Reactive, Protein/*analysis, Cardiovascular, Diseases/blood/*epidemiology, Cholesterol, LDL/*blood, Disease-Free, Survival, Female, Hormone, Replacement, Therapy, Humans, Incidence, Longitudinal, Studies, Middle, Aged, Multivariate, Analysis, Prognosis, ROC, Curve, Risk, Risk, Factors},
 title_with_no_special_chars = {Comparison of Creactive protein and lowdensity lipoprotein cholesterol levels in the prediction of first cardiovascular events}
}

@article{schlienger_use_2002,
	title = {Use of nonsteroidal anti-inflammatory drugs and the risk of first-time acute myocardial infarction},
	volume = {54},
	issn = {0306-5251},
	abstract = {AIMS: Aspirin decreases the risk of clinical manifestations of atherothrombosis. This effect is mainly due to inhibition of platelet aggregation and potentially due to anti-inflammatory properties of aspirin. To evaluate whether use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) may also be associated with a decreased risk of first-time acute myocardial infarction (AMI), we performed a population-based case-control analysis using the United Kingdom-based General Practice Research Database (GPRD) METHODS: We identified first-time AMI-patients free of preexisting diagnosed cardiovascular or metabolic diseases. We compared use of NSAIDs prior to the index date between cases and control patients who were matched to cases on age, gender, practice and calendar time.
RESULTS: A total of 3319 cases ({\textless}or=75 years) with a diagnosis of first-time AMI between 1992 and 1997 and 13139 controls (matched to cases on age, sex, general practice attended, calendar time, years of prior history in the GPRD) were included. Overall, the relative risk estimate of AMI (adjusted for smoking, body mass index, hormone replacement therapy and aspirin) in current NSAID users was 1.17 (95\% CI 0.99, 1.37). Long-term current NSAID use ({\textgreater}or=30 prescriptions) yielded an adjusted odds ratio (OR) of 1.20 (95\% CI 0.94, 1.55). Stratification by age ({\textless}65 years vs{\textgreater}or=65 years) and sex did not materially change the results.
CONCLUSIONS: Our findings indicate that current NSAID exposure in patients free of diagnosed cardiovascular or metabolic conditions predisposing to cardiovascular diseases does not decrease the risk of AMI.},
	language = {eng},
	number = {3},
	journal = {British Journal of Clinical Pharmacology},
	author = {Schlienger, Raymond G. and Jick, Hershel and Meier, Christoph R.},
	month = sep,
	year = {2002},
	pmid = {12236854},
	pmcid = {PMC1874430},
	keywords = {Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Female, Great Britain, Humans, Male, Middle Aged, Myocardial Infarction, Risk Assessment, Risk Factors},
	pages = {327--332}
}

@Article{Fayad_2002_1428,
  author = {Fayad, Z. A.},
 journal = {Neuroimaging Clin.N.Am.},
 note = {DA - 20021218 NOT IN FILE},
 number = {3},
 pages = {461-471},
 title = {Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI},
 volume = {12},
 year = {2002},
 keywords = {Animals, Arteries, Arteriosclerosis, Atherosclerosis, Contrast, Media, Coronary, Arteriosclerosis, Coronary, Vessels, diagnosis, Disease, Progression, Humans, Magnetic, Resonance, Angiography, Magnetic, Resonance, Imaging, methods, pathology, Research, Support, Non-U.S.Gov't, Research, Support, U.S.Gov't, P.H.S., Rupture, therapy},
 title_with_no_special_chars = {Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI}
}

@Article{Higuchi_2002_1340,
  author = {Higuchi, M. L. and Gutierrez, P. S. and Bezerra, H. G. and Palomino, S. A. and Aiello, V. D. and Silvestre, J. M. and Libby, P. and Ramires, J. A.},
 journal = {Arq Bras.Cardiol.},
 note = {DA - 20020806 NOT IN FILE},
 number = {1},
 pages = {20-24},
 title = {Comparison between adventitial and intimal inflammation of ruptured and nonruptured atherosclerotic plaques in human coronary arteries},
 volume = {79},
 year = {2002},
 keywords = {Aneurysm, Arteries, Arteritis, Cadaver, Coronary, Arteriosclerosis, Coronary, Vessels, Endothelium, Vascular, Fibrosis, Humans, Inflammation, Lymphocyte, Count, Lymphocytes, methods, Myocardial, Infarction, pathology, Research, Support, Non-U.S.Gov't, Rupture},
 title_with_no_special_chars = {Comparison between adventitial and intimal inflammation of ruptured and nonruptured atherosclerotic plaques in human coronary arteries}
}

@article{coleman_endemic_2001,
	title = {Endemic stability--a veterinary idea applied to human public health.},
	volume = {357},
	issn = {0140-6736 0140-6736},
	abstract = {Endemic stability is an epidemiological state of a population, in which clinical  disease is scarce despite high level of infection. The notion was developed to describe patterns of tick-borne disease in cattle. However, we propose a general  model of endemic stability that is applicable to a broader range of diseases that are important in public health, including malaria, rubella, and mumps. We postulate that endemic stability requires only that (1) the probability, or severity, of clinical disease after infection increases with age, and (2) after one infection, the probability that subsequent infections result in disease is reduced. We present these criteria in simple mathematical terms. Our hypothesis predicts that partial disease control activities might, under certain circumstances, lead to an increase in disease incidence. We discuss the implications for public health interventions.},
	language = {eng},
	number = {9264},
	journal = {Lancet (London, England)},
	author = {Coleman, P. G. and Perry, B. D. and Woolhouse, M. E.},
	month = apr,
	year = {2001},
	pmid = {11418173},
	keywords = {*Endemic Diseases, *Epidemiologic Methods, *Models, Theoretical, *Public Health, Age Distribution, Animals, Child, Preschool, Communicable Diseases/*epidemiology/etiology, Humans, Incidence, Infant, Infant, Newborn},
	pages = {1284--1286}
}

@article{spiegelhalter_bayesian_2000-1,
	title = {Bayesian methods in health technology assessment: a review},
	volume = {4},
	issn = {1366-5278},
	shorttitle = {Bayesian methods in health technology assessment},
	abstract = {BACKGROUND: Bayesian methods may be defined as the explicit quantitative use of external evidence in the design, monitoring, analysis, interpretation and reporting of a health technology assessment. In outline, the methods involve formal combination through the use of Bayes's theorem of: 1. a prior distribution or belief about the value of a quantity of interest (for example, a treatment effect) based on evidence not derived from the study under analysis, with 2. a summary of the information concerning the same quantity available from the data collected in the study (known as the likelihood), to yield 3. an updated or posterior distribution of the quantity of interest. These methods thus directly address the question of how new evidence should change what we currently believe. They extend naturally into making predictions, synthesising evidence from multiple sources, and designing studies: in addition, if we are willing to quantify the value of different consequences as a 'loss function', Bayesian methods extend into a full decision-theoretic approach to study design, monitoring and eventual policy decision-making. Nonetheless, Bayesian methods are a controversial topic in that they may involve the explicit use of subjective judgements in what is conventionally supposed to be a rigorous scientific exercise. OBJECTIVES: This report is intended to provide: 1. a brief review of the essential ideas of Bayesian analysis 2. a full structured review of applications of Bayesian methods to randomised controlled trials, observational studies, and the synthesis of evidence, in a form which should be reasonably straightforward to update 3. a critical commentary on similarities and differences between Bayesian and conventional approaches 4. criteria for assessing the reporting of a Bayesian analysis 5. a comprehensive list of published 'three-star' examples, in which a proper prior distribution has been used for the quantity of primary interest 6. tutorial case studies of a variety of types 7. recommendations on how Bayesian methods and approaches may be assimilated into health technology assessments in a variety of contexts and by a variety of participants in the research process. METHODS: The BIDS ISI database was searched using the terms 'Bayes' or 'Bayesian'. This yielded almost 4000 papers published in the period 1990-98. All resultant abstracts were reviewed for relevance to health technology assessment; about 250 were so identified, and used as the basis for forward and backward searches. In addition EMBASE and MEDLINE databases were searched, along with websites of prominent authors, and available personal collections of references, finally yielding nearly 500 relevant references. A comprehensive review of all references describing use of 'proper' Bayesian methods in health technology assessment (those which update an informative prior distribution through the use of Bayes's theorem) has been attempted, and around 30 such papers are reported in structured form. There has been very limited use of proper Bayesian methods in practice, and relevant studies appear to be relatively easily identified. RESULTS: Bayesian methods in the health technology assessment context 1. Different contexts may demand different statistical approaches. Prior opinions are most valuable when the assessment forms part of a series of similar studies. A decision-theoretic approach may be appropriate where the consequences of a study are reasonably predictable. 2. The prior distribution is important and not unique, and so a range of options should be examined in a sensitivity analysis. Bayesian methods are best seen as a transformation from initial to final opinion, rather than providing a single 'correct' inference. 3. The use of a prior is based on judgement, and hence a degree of subjectivity cannot be avoided. However, subjective priors tend to show predictable biases, and archetypal priors may be useful for identifying a reasonable range of prior opinion.},
	language = {eng},
	number = {38},
	journal = {Health Technology Assessment (Winchester, England)},
	author = {Spiegelhalter, D. J. and Myles, J. P. and Jones, D. R. and Abrams, K. R.},
	year = {2000},
	pmid = {11134920},
	keywords = {Bayes Theorem, Biomedical, Biomedical Technology, Humans, Sensitivity and Specificity, Technology Assessment, United Kingdom},
	pages = {1--130},
}

Paper  abstract   bibtex   

@article{krause_effects_2000,
	title = {The effects of memory load on event-related {EEG} desynchronization and synchronization.},
	volume = {111},
	issn = {1388-2457},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11068244},
	abstract = {OBJECTIVES: To examine the effects of working memory load on the event-related desynchronization (ERD) and synchronization (ERS) of several narrow EEG frequency bands.

METHODS: ERD/ERS responses of the 4-6, 6-8, 8-10 and 10-12 Hz EEG frequency bands were studied in 24 normal subjects performing a visual sequential letter task (so-called n-back task) in which memory load was varied from 0 to 2.

RESULTS: In the 4-6 Hz theta frequency band, a long-lasting synchronization was observed in the anterior electrodes, especially after the presentation of targets. In the 6-8 and 8-10 Hz frequency bands, anterior ERS was elicited especially in the 2-back condition (highest memory load). In contrast to the responses of the 8-10 Hz frequency band, in the 10-12 Hz frequency band the 2-back experimental condition elicited the greatest ERD.

CONCLUSIONS: In the highest memory load (2-back) experimental condition the attentional capacities were most probably exceeded, resulting in 6-8 and 8-10 Hz ERS. This might reflect an inhibition of such brain areas (frontal cortices) no longer involved in task completion when alternative strategies are needed and utilized. These more 'cognitive' strategies were then reflected as an increase in 10-12 Hz ERD. Additionally, our results support the assumption that the simultaneously recorded ERD/ERS responses of different narrow EEG frequency bands differ and reflect distinct aspects of information processing.},
	number = {11},
	urldate = {2015-05-08},
	journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
	author = {Krause, C M and Sillanmäki, L and Koivisto, M and Saarela, C and Häggqvist, A and Laine, M and Hämäläinen, H},
	month = nov,
	year = {2000},
	pmid = {11068244},
	keywords = {Adult, Brain, Brain: physiology, Cortical Synchronization, Electroencephalography, Evoked Potentials, Evoked Potentials: physiology, Female, Humans, Male, Memory, Memory: physiology},
	pages = {2071--8},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Determination of dioxins/furans and PCBs by quadrupole ion-trap gas chromatography-mass spectrometry.},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Animals,Furans,Furans: analysis,Furans: toxicity,Gas Chromatography-Mass Spectrometry,Gas Chromatography-Mass Spectrometry: instrumentat,Gas Chromatography-Mass Spectrometry: methods,Humans,Polychlorinated Biphenyls,Polychlorinated Biphenyls: analysis,Polychlorinated Biphenyls: toxicity,Tetrachlorodibenzodioxin,Tetrachlorodibenzodioxin: analogs & derivatives,Tetrachlorodibenzodioxin: analysis,Tetrachlorodibenzodioxin: toxicity},
 pages = {305-65},
 volume = {19},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11079247},
 id = {99906347-4120-3a61-9bc4-5bb2ae3a2e80},
 created = {2014-05-31T04:14:15.000Z},
 file_attached = {true},
 profile_id = {9edae5ec-3a23-3830-8934-2c27bef6ccbe},
 group_id = {63e349d6-2c70-3938-9e67-2f6483f6cbab},
 last_modified = {2014-11-19T06:02:42.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {The versatility and sensitivity of the quadrupole ion trap tandem mass spectrometer has been applied to the determination of polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs), and of polychlorinated biphenyls (PCBs). A brief introduction to the theory of ion confinement in a quadrupole ion trap permits discussion of ion trajectory stability, mass-selective ion ejection, the frequencies of ion motion, and the role of resonant excitation of ion motion. The tandem mass spectrometric examination of PCDDs and PCDFs eluting and co-eluting from a gas chromatographic column is described. Illustrative examples are given of the analysis of field samples containing PCDDs and PCDFs. A comparison is presented of the performance of each of a quadrupole ion trap tandem mass spectrometer, a triple stage quadrupole mass spectrometer, and a sector instrument of relatively high mass resolution for the determination of PCDDs and PCDFs. This comparison is made with respect to instrument tuning, calibration plots, detection limits, ion signals at low concentration, relative response factors, ionization cross-sections, and the examination of field samples. The application of quadrupole ion trap tandem mass spectrometry to the examination of PCBs is focused upon those PCB congeners that have the greatest toxicity. 39 congeners of the total of 209 PCB congeners have been identified as having the greatest toxicities. Chemical ionization has been used for the determination of co-eluting congeners #77 and #110 where the toxicity of the former is much greater than that of the latter. An analytical protocol, based on the variation of molecular ion fragmentation according to the degree (or absence) of chlorine ortho-substitution, has been proposed for distinguishing between toxic and nontoxic PCB congeners.},
 bibtype = {article},
 author = {Plomley, J B and Lausevic, M and March, R E},
 journal = {Mass spectrometry reviews},
 number = {5}
}

@article{van_staa_oral_2000,
	title = {Oral corticosteroids and fracture risk: relationship to daily and cumulative doses},
	volume = {39},
	issn = {1462-0324},
	shorttitle = {Oral corticosteroids and fracture risk},
	abstract = {OBJECTIVE: This study examined the effects of daily and cumulative oral corticosteroid doses on the risk of fractures.
METHODS: Information was obtained from the General Practice Research Database, which contains medical records of general practitioners in England and Wales. The study included 244 235 oral corticosteroid users and 244 235 controls.
RESULTS: Patients taking higher doses (at least 7. 5 mg daily of prednisolone or equivalent) had significantly increased risks of non-vertebral fracture [relative rate (RR)=1.44, 95\% confidence interval (CI) 1.34-1.54], hip fracture (RR=2.21, 95\% CI 1.85-2.64) and vertebral fracture (RR=2.83, 95\% CI 2.35-2.40) relative to patients using oral corticosteroids at lower doses (less than 2.5 mg per day). Fracture risk was also elevated among people with higher cumulative exposure to oral corticosteroids over the study period, but this effect was almost wholly removed by adjustment for daily dose, age, gender and other confounding variables.
CONCLUSIONS: These findings suggest that the adverse skeletal effects of oral corticosteroids manifest rapidly and are related to daily dose. The level of previous exposure to oral corticosteroids was not a strong determinant of the risk of fracture. Preventive measures against corticosteroid-induced osteoporosis should therefore be instituted as soon after the commencement of glucocorticoid therapy as possible.},
	language = {eng},
	number = {12},
	journal = {Rheumatology (Oxford, England)},
	author = {van Staa, T. P. and Leufkens, H. G. and Abenhaim, L. and Zhang, B. and Cooper, C.},
	month = dec,
	year = {2000},
	pmid = {11136882},
	keywords = {Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Dose-Response Relationship, Drug, Female, Fractures, Bone, Humans, Middle Aged, Osteoporosis, Registries, Risk Factors},
	pages = {1383--1389}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry},
 type = {article},
 year = {1999},
 identifiers = {[object Object]},
 keywords = {Base Sequence,Canada,Canada/ethnology,Canada: ethnology,DNA-Binding Proteins,DNA-Binding Proteins/*genetics,DNA-Binding Proteins: genetics,Ethnic Groups,Ethnic Groups/*genetics,Ethnic Groups: genetics,Female,France,France/ethnology,France: ethnology,Human,Humans,Louisiana,Male,Microsatellite Repeats,Microsatellite Repeats/*genetics,Microsatellite Repeats: genetics,Muscular Dystrophies,Muscular Dystrophies/*genetics,Muscular Dystrophies: genetics,Non-U.S. Gov't,Pedigree,Poly(A)-Binding Protein II,Support},
 pages = {477-481},
 volume = {86},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/10508991},
 month = {10},
 day = {29},
 id = {45d065a8-6799-3e6b-880b-3fa24b3356fa},
 created = {2017-06-19T13:42:02.365Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:42:02.505Z},
 tags = {04/09/07},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>        <m:bold>From Duplicate 1 ( </m:bold>                <m:bold>          </m:bold><m:bold><m:italic>Unique PABP2 mutations in &quot;Cajuns&quot; suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry</m:italic></m:bold><m:bold>        </m:bold>                <m:bold> - Scacheri, P C; Garcia, C; Hebert, R; Hoffman, E P )<m:linebreak/>        </m:bold>        <m:linebreak/>Journal Article<m:linebreak/>        <m:linebreak/>      </m:note>},
 abstract = {Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset autosomal dominant myopathy found world-wide, but with the highest incidence in French-Canadians. Short GCG expansions in the poly(A) binding protein 2 (PABP2) gene were identified recently as the molecular basis for OPMD in French-Canadians. All French-Canadian cases of OPMD have been traced to a single founder couple [Bouchard, 1997: Neuromuscul Disord 7(Suppl):S5-S11]. Cultural links between French-Canadians and Cajuns suggest that this same founder couple may have transmitted the OPMD mutation to Cajuns as well. To determine if OPMD patients from Louisiana share a founder effect with French-Canadian families, we collected blood samples and muscle biopsies from several Cajuns with OPMD for mutation and linkage studies. We found a unique 'GCA GCG GCG' insertion mutation in Cajuns. Consistent with these sequence data, we identified a disease haplotype in our Cajun families that is different from the ancestral haplotype defined in French-Canadians. These data prove that different founders introduced the PABP2 mutation to Cajuns and French-Canadians and lend support to emerging genealogical data suggesting that French-Canadians and Cajuns represent distinct immigrant groups from France.},
 bibtype = {article},
 author = {Scacheri, P C and Garcia, C and Hébert, R and Hoffman, E P and Hebert, R},
 journal = {Am J Med Genet},
 number = {5}
}

@article{
 title = {Visual-proprioceptive mapping in children with developmental coordination disorder},
 type = {article},
 year = {1999},
 identifiers = {[object Object]},
 keywords = {Case-Control Studies,Child,Female,Growth Disorders,Humans,Male,Motor Skills,Preschool,Proprioception,Vision,physiopathology,psychology},
 pages = {247-254},
 volume = {41},
 id = {2a1d6312-9620-3630-b63f-f17c2d8e07ef},
 created = {2016-01-12T14:17:48.000Z},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Developmental coordination disorder (DCD) occurs in a small but significant proportion of children who present with impaired body-eye coordination and show poor acquisition of motor skills. This study investigated the visual-proprioceptive mapping ability of children with DCD from a small selected group, with particular reference to the use of vision in matching tasks. The children with DCD in this study were significantly poorer than control children on all matching tasks. They seemed to have particular difficulty in cross-modal judgements that required the use of visual information to guide proprioceptive judgements of limb position. A distinction is drawn between tasks that can be achieved purely through sensory matching and those that require body-centred spatial judgements, suggesting that it is the latter that posits a particular difficulty for children with DCD},
 bibtype = {article},
 author = {Mon-Williams, M A and Wann, J P and Pascal, E},
 journal = {Developmental Medicine & Child Neurology},
 number = {4}
}

Paper  doi  abstract   bibtex   

@article{loeffelholz_comparison_1999,
	title = {Comparison of {PCR}, culture, and direct fluorescent-antibody testing for detection of {Bordetella} pertussis},
	volume = {37},
	issn = {0095-1137},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/10449467},
	doi = {10449467},
	abstract = {We prospectively compared the performance of culture, direct fluorescent-antibody testing (DFA), and an in-house-developed PCR test targeting the repeated insertion sequence IS481 for the detection of Bordetella pertussis in nasopharyngeal swab specimens. We tested 319 consecutive paired specimens on which all three tests were performed. A total of 59 specimens were positive by one or more tests. Of these, 5 were positive by all three tests, 2 were positive by culture and PCR, 16 were positive by PCR and DFA, 28 were positive by PCR only, and 8 were positive by DFA only. Any specimen positive by culture was considered to be a true positive, as were specimens positive by both PCR and DFA. Specimens positive only by PCR or DFA were considered discrepant, and their status was resolved by review of patient histories. Patients with symptoms meeting the Centers for Disease Control and Prevention clinical case definition for pertussis and who had a specimen positive by PCR or DFA were considered to have true B. pertussis infections. Of the 28 patients positive by PCR only, 20 met the clinical case definition for pertussis, while 3 of the 8 patients positive by DFA only met the clinical case definition. After resolution of the status of discrepant specimens, the sensitivity, specificity, positive predictive value, and negative predictive value were 15.2, 100, 100, and 87.5\%, respectively, for culture; 93.5, 97.1, 84.3, and 98.9\%, respectively, for PCR; and 52.2, 98.2, 82.8, and 92.4\%, respectively, for DFA. The actual positive predictive value of PCR was probably greater, as several PCR-positive patients who did not meet the clinical case definition had symptoms consistent with typical or atypical pertussis. PCR is a sensitive and specific method for the detection of B. pertussis.},
	number = {9},
	urldate = {2008-10-01},
	journal = {Journal of Clinical Microbiology},
	author = {Loeffelholz, M J and Thompson, C J and Long, K S and Gilchrist, M J},
	month = sep,
	year = {1999},
	pmid = {10449467},
	keywords = {Adult, Bordetella pertussis, Child, Fluorescent Antibody Technique, Direct, Humans, Nasopharynx, Polymerase Chain Reaction, Prospective Studies, Sensitivity and Specificity},
	pages = {2872--6},
}

Paper  abstract   bibtex   

@article{parrens_angiome_1998,
	title = {L'angiome à cellules littorales: une tumeur vasculaire rare de la rate [{Littoral} cell angioma: a rare vascular splenic tumor]},
	volume = {18},
	issn = {0242-6498},
	shorttitle = {[{Littoral} cell angioma},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/10051916},
	abstract = {Littoral cell angioma is a rare primitive vascular tumor of the spleen considered as benign. Its clinical presentation is non specific. The diagnostic is based on histological and immunohistological analysis. The lesion is composed of anastomosing vascular channels often featuring papillary projections. They are lined by tumoral cells which exhibit an immunoreactivity for vascular and histiomonocytic markers. We report one case of littoral cell angioma and we discuss the diagnosis and the histogenesis of this tumor.},
	number = {6},
	urldate = {2012-03-26},
	journal = {Annales De Pathologie},
	author = {Parrens, M and Nouts, C and Belleanne, G and Dubus, P and Beylot, J and de Mascarel, A},
	month = dec,
	year = {1998},
	pmid = {10051916},
	keywords = {Aged, Antigens, CD, Antigens, CD31, Antigens, Differentiation, Myelomonocytic, Factor VIII, Hemangioma, Humans, Immunohistochemistry, Male, Spleen, Splenic Neoplasms, von Willebrand Factor},
	pages = {484--487},
}

Website  abstract   bibtex   

@article{
 title = {Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group},
 type = {article},
 year = {1996},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Age Distribution,Aged,Aged, 80 and over,Allergens/diagnostic use,Asthma/epidemiology/*genetics,Atlantic Ocean,Bronchoconstrictor Agents/diagnostic use,Child,Child, Preschool,Consanguinity,Female,Forced Expiratory Volume,Founder Effect,Humans,Linkage (Genetics),Male,Methacholine Chloride/diagnostic use,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Sex Distribution,Skin Tests},
 pages = {1902-1906},
 volume = {153},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8665053},
 id = {ba377ad3-36ac-3937-b8d3-44f6b08c99e3},
 created = {2017-06-19T13:44:45.103Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:45.287Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1073-449x<m:linebreak/>Journal Article</m:note>},
 abstract = {Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus increasing the probability of gene localization. We studied the inbred population of the remote island of Tristan da Cunha to document asthma prevalence for the purpose of genetic linkage analysis. Medical histories and skin atopy were determined on 282 islanders, representing 97% of the population, and airway responsiveness was measured in 254; 226 by methacholine challenge (tidal breathing method) and 28 by bronchodilator response (400 micrograms salbutamol aerosol). Blood samples were collected from 275 islanders. Participants ranged in age from 3 to 94 yr. Asthma was defined as increased airway responsiveness (AR+: PC20 < 4 mg/ml or > or = 15% increase in FEV1 postbronchodilator) combined with a positive history (Hx+). Fifty-seven percent of the islanders had at least partial evidence of asthma (Hx+ and/or AR+) and 23% had a definitive diagnosis of asthma (AR+ with Hx+). Overall 47% of the population were atopic, atopy was proportionally higher in asthmatics (74%) than nonasthmatics (32%; p < 0.01). Analysis of the methacholine dose-response curves demonstrated that asthmatics were significantly (p < 0.01) more responsive than those with AR+ only, and nonasthmatics (AR-, Hx-) were more responsive than laboratory control subjects (p < 0.05), suggesting that these islanders may also carry an airway hyperresponsiveness gene. A frequency plot of the percent fall in FEV1 for all Hx- subjects compared with control data suggests a bimodal distribution consistent with a major gene mechanism for airway responsiveness. Genealogy mapping revealed that the islanders are direct descendants of the 15 original settlers, and historical records suggest at least two founders may have been asthmatic. The data confirm previous reports of a high asthma prevalence on Tristan and support the postulate that this prevalence is a result of gene enrichment occurring in isolated populations by virtue of extensive inbreeding and a probable founder effect.},
 bibtype = {article},
 author = {Zamel, N and McClean, P A and Sandell, P R and Siminovitch, K A and Slutsky, A S},
 journal = {Am J Respir Crit Care Med},
 number = {6 Pt 1}
}

@article{adkin_effect_1995,
	title = {The effect of mannitol on the oral bioavailability of cimetidine},
	volume = {84},
	issn = {0022-3549 (Print) 0022-3549 (Linking)},
	doi = {10.1002/jps.2600841205},
	abstract = {The aim of the study was to investigate whether mannitol at amounts relevant to pharmaceutical formulations would alter the oral bioavailability of cimetidine, a drug primarily absorbed from the small bowel. Seven healthy male subjects each received four formulations, a chewable tablet or a solution, containing 0.200 g of cimetidine and either 2.264 g of mannitol or sucrose, in a randomized four-way cross-over study. Frequent blood samples were taken over a 24 h period to allow a cimetidine plasma profile to be obtained for each formulation. Transit of the radiolabeled formulations was followed by gamma scintigraphy. Statistically significant reductions in the AUC0-24 and maximum plasma concentration values were observed with the mannitol dosage forms compared to the sucrose controls. The mean small intestinal transit times were shortened after administration of the mannitol solution and tablet; the transit time of the solution was significantly shorter with values 23\% of those for the sucrose solution. The implication of the study findings is that excipients cannot always be regarded as "inert" substances that can be incorporated into a formulation without having any deleterious effect on the overall in vivo behaviour of the product.},
	number = {12},
	journal = {J Pharm Sci},
	author = {Adkin, D. A. and Davis, S. S. and Sparrow, R. A. and Huckle, P. D. and Wilding, I. R.},
	month = dec,
	year = {1995},
	keywords = {Administration, Oral, Adult, Anti-Ulcer Agents/*pharmacokinetics, Biological Availability, Cimetidine/*pharmacokinetics, Cross-Over Studies, Humans, Male, Mannitol/*pharmacology, Solutions, Sucrose/pharmacology, Tablets},
	pages = {1405--9},
}

@Article{Potter1975,
  author   = {Mary C. Potter},
  journal  = {Science},
  title    = {Meaning in visual search.},
  year     = {1975},
  number   = {4180},
  pages    = {965-6},
  volume   = {187},
  abstract = {Viewers briefly glimpsed pictures presented in a sequence at rates
	up to eight per second. They recognized a target picture as accurately
	and almost as rapidly when they knew only its meaning given by a
	name (for example, a boat) as when they had seen the picture itself
	in advance.},
  keywords = {Adult, Form Perception, Humans, Memory, Pattern Recognition, Reaction Time, Visual, 1145183},
}