@article{afiahayati_metavelvet-sl:_2015,
	title = {{MetaVelvet}-{SL}: an extension of the {Velvet} assembler to a de novo metagenomic assembler utilizing supervised learning},
	volume = {22},
	issn = {1756-1663},
	shorttitle = {{MetaVelvet}-{SL}},
	doi = {10.1093/dnares/dsu041},
	abstract = {The assembly of multiple genomes from mixed sequence reads is a bottleneck in metagenomic analysis. A single-genome assembly program (assembler) is not capable of resolving metagenome sequences, so assemblers designed specifically for metagenomics have been developed. MetaVelvet is an extension of the single-genome assembler Velvet. It has been proved to generate assemblies with higher N50 scores and higher quality than single-genome assemblers such as Velvet and SOAPdenovo when applied to metagenomic sequence reads and is frequently used in this research community. One important open problem for MetaVelvet is its low accuracy and sensitivity in detecting chimeric nodes in the assembly (de Bruijn) graph, which prevents the generation of longer contigs and scaffolds. We have tackled this problem of classifying chimeric nodes using supervised machine learning to significantly improve the performance of MetaVelvet and developed a new tool, called MetaVelvet-SL. A Support Vector Machine is used for learning the classification model based on 94 features extracted from candidate nodes. In extensive experiments, MetaVelvet-SL outperformed the original MetaVelvet and other state-of-the-art metagenomic assemblers, IDBA-UD, Ray Meta and Omega, to reconstruct accurate longer assemblies with higher N50 scores for both simulated data sets and real data sets of human gut microbial sequences.},
	language = {eng},
	number = {1},
	journal = {DNA research: an international journal for rapid publication of reports on genes and genomes},
	author = {Afiahayati, null and Sato, Kengo and Sakakibara, Yasubumi},
	month = feb,
	year = {2015},
	pmid = {25431440},
	pmcid = {PMC4379979},
	keywords = {Genome, Humans, Metagenome, Metagenomic, Sequence Analysis, DNA, Software, Support Vector Machine, de novo assembler, microbial community, short read, supervised learning},
	pages = {69--77}
}

@article{savitski_scalable_2015,
	title = {A {Scalable} {Approach} for {Protein} {False} {Discovery} {Rate} {Estimation} in {Large} {Proteomic} {Data} {Sets}},
	volume = {14},
	issn = {1535-9484},
	doi = {10.1074/mcp.M114.046995},
	abstract = {Calculating the number of confidently identified proteins and estimating false discovery rate (FDR) is a challenge when analyzing very large proteomic data sets such as entire human proteomes. Biological and technical heterogeneity in proteomic experiments further add to the challenge and there are strong differences in opinion regarding the conceptual validity of a protein FDR and no consensus regarding the methodology for protein FDR determination. There are also limitations inherent to the widely used classic target-decoy strategy that particularly show when analyzing very large data sets and that lead to a strong over-representation of decoy identifications. In this study, we investigated the merits of the classic, as well as a novel target-decoy-based protein FDR estimation approach, taking advantage of a heterogeneous data collection comprised of ∼19,000 LC-MS/MS runs deposited in ProteomicsDB (https://www.proteomicsdb.org). The "picked" protein FDR approach treats target and decoy sequences of the same protein as a pair rather than as individual entities and chooses either the target or the decoy sequence depending on which receives the highest score. We investigated the performance of this approach in combination with q-value based peptide scoring to normalize sample-, instrument-, and search engine-specific differences. The "picked" target-decoy strategy performed best when protein scoring was based on the best peptide q-value for each protein yielding a stable number of true positive protein identifications over a wide range of q-value thresholds. We show that this simple and unbiased strategy eliminates a conceptual issue in the commonly used "classic" protein FDR approach that causes overprediction of false-positive protein identification in large data sets. The approach scales from small to very large data sets without losing performance, consistently increases the number of true-positive protein identifications and is readily implemented in proteomics analysis software.},
	language = {eng},
	number = {9},
	journal = {Molecular \& cellular proteomics: MCP},
	author = {Savitski, Mikhail M. and Wilhelm, Mathias and Hahne, Hannes and Kuster, Bernhard and Bantscheff, Marcus},
	month = sep,
	year = {2015},
	pmid = {25987413},
	pmcid = {PMC4563723},
	keywords = {Chromatography, Liquid, Databases, Protein, False Positive Reactions, Humans, Proteomics, Reproducibility of Results, Software, Tandem Mass Spectrometry},
	pages = {2394--2404}
}

@article{munden_prospective_2014,
	title = {Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies},
	volume = {170},
	issn = {1365-2133},
	shorttitle = {Prospective study of infantile haemangiomas},
	doi = {10.1111/bjd.12804},
	abstract = {BACKGROUND: The aetiology and exact incidence of infantile haemangiomas (IHs) are unknown. Prior studies have noted immunohistochemical and biological characteristics shared by IHs and placental tissue.
OBJECTIVES: We investigated the possible association between placental anomalies and the development of IHs, as well as the demographic characteristics and other risk factors for IHs.
PATIENTS AND METHODS: Pregnant women (n = 578) were prospectively enrolled and their offspring followed for 9 months. Placental evaluations were performed and demographic data collected on all mother-infant pairs.
RESULTS: We evaluated 594 infants: 34 haemangiomas [either IH or congenital (CH)] were identified in 29 infants, yielding an incidence of 4·5\% for IH (27 infants) and 0·3\% for CH (two infants). Placental anomalies were noted in almost 35\% of haemangioma-related pregnancies, approximately twice the incidence noted in pregnancies with unaffected infants (P = 0·025). Other risk factors for IH included prematurity (P = 0·016) and low birth weight (P = 0·028). All IHs were present by 3 months of age, and cessation of growth had occurred in all by 9 months of age. Most occurred on the trunk. Of note, 20\% of identified IHs were abortive or telangiectatic in nature, small focal lesions that did not proliferate beyond 3 months of age. Only one IH required intervention.
CONCLUSIONS: This is the first prospective American study to document the incidence of IHs in infants followed from birth to early infancy. The association with placental anomalies was statistically significant. The overall incidence mirrors prior estimates, but the need for treatment was lower than previously reported.},
	language = {eng},
	number = {4},
	journal = {The British Journal of Dermatology},
	author = {Munden, A. and Butschek, R. and Tom, W. L. and Marshall, J. S. and Poeltler, D. M. and Krohne, S. E. and Alió, A. B. and Ritter, M. and Friedlander, D. F. and Catanzarite, V. and Mendoza, A. and Smith, L. and Friedlander, M. and Friedlander, S. F.},
	month = apr,
	year = {2014},
	pmid = {24641194},
	pmcid = {PMC4410180},
	keywords = {Adolescent, Adult, California, Female, Hemangioma, Humans, Incidence, Infant, Male, Maternal Age, Middle Aged, Placenta Diseases, Pregnancy, Prospective Studies, Risk Factors, Young Adult},
	pages = {907--913}
}

@article{hippisley-cox_performance_2014,
	title = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice: a validation study},
	volume = {4},
	issn = {2044-6055},
	shorttitle = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice},
	doi = {10.1136/bmjopen-2014-005809},
	abstract = {OBJECTIVES: To validate the performance of a set of risk prediction algorithms developed using the QResearch database, in an independent sample from general practices contributing to the Clinical Research Data Link (CPRD).
SETTING: Prospective open cohort study using practices contributing to the CPRD database and practices contributing to the QResearch database.
PARTICIPANTS: The CPRD validation cohort consisted of 3.3 million patients, aged 25-99 years registered at 357 general practices between 1 Jan 1998 and 31 July 2012. The validation statistics for QResearch were obtained from the original published papers which used a one-third sample of practices separate to those used to derive the score. A cohort from QResearch was used to compare incidence rates and baseline characteristics and consisted of 6.8 million patients from 753 practices registered between 1 Jan 1998 and until 31 July 2013.
OUTCOME MEASURES: Incident events relating to seven different risk prediction scores: QRISK2 (cardiovascular disease); QStroke (ischaemic stroke); QDiabetes (type 2 diabetes); QFracture (osteoporotic fracture and hip fracture); QKidney (moderate and severe kidney failure); QThrombosis (venous thromboembolism); QBleed (intracranial bleed and upper gastrointestinal haemorrhage). Measures of discrimination and calibration were calculated.
RESULTS: Overall, the baseline characteristics of the CPRD and QResearch cohorts were similar though QResearch had higher recording levels for ethnicity and family history. The validation statistics for each of the risk prediction scores were very similar in the CPRD cohort compared with the published results from QResearch validation cohorts. For example, in women, the QDiabetes algorithm explained 50\% of the variation within CPRD compared with 51\% on QResearch and the receiver operator curve value was 0.85 on both databases. The scores were well calibrated in CPRD.
CONCLUSIONS: Each of the algorithms performed practically as well in the external independent CPRD validation cohorts as they had in the original published QResearch validation cohorts.},
	language = {eng},
	number = {8},
	journal = {BMJ open},
	author = {Hippisley-Cox, Julia and Coupland, Carol and Brindle, Peter},
	year = {2014},
	pmid = {25168040},
	pmcid = {PMC4156807},
	keywords = {Adult, Aged, Aged, 80 and over, Algorithms, Calibration, Cardiovascular Diseases, Cprd, Ethnic Groups, Family, Female, General Practice, Hemorrhage, Humans, Kidney Diseases, Male, Middle Aged, Osteoporotic Fractures, Prognosis, Prospective Studies, QResearch, Qrisk2, Risk, Validation, Venous Thromboembolism, diabetes mellitus},
	pages = {e005809}
}

@article{
 title = {How much do residential aged care staff members know about the nutritional needs of residents?},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Attitude of Health Personnel,Cross-Sectional Studies,Dementia/nursing,Female,Geriatric Nursing/methods,Health Care Surveys,Health Knowledge, Attitudes, Practice,Humans,Male,Malnutrition/nursing,Meals,Middle Aged,Nursing Staff,Nutrition Assessment,Quality of Life/psychology,Residential Facilities,malnutrition,mealtime practices,nutrition knowledge,old age,residential care,staff},
 pages = {54-64},
 volume = {9},
 month = {3},
 publisher = {Blackwell Publishing Ltd},
 city = {Dementia Collaborative Research Centre: Carers & Consumers, Queensland University of Technology, Brisbane, Australia; Dementia Training Studies Centre, Queensland University of Technology, Brisbane, Australia; School of Nursing, Queensland University of T},
 id = {ddcbb97d-cbf9-341d-982c-c02ae2ebd52c},
 created = {2016-08-20T16:52:30.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 74113; CI: (c) 2013; JID: 101267281; OTO: NOTNLM; 2012/08/03 [received]; 2012/11/21 [accepted]; 2013/02/11 [aheadofprint]; ppublish},
 folder_uuids = {06271a48-ad48-43cc-b073-52e57f10f5e1},
 private_publication = {false},
 abstract = {BACKGROUND: Undernutrition, weight loss and dehydration are major clinical issues for people with dementia in residential care, with excessive weight loss contributing to increased risk of frailty, immobility, illness and premature morbidity. This paper discusses a nutritional knowledge and attitudes survey conducted as part of a larger project focused on improving nutritional intake of people with dementia within a residential care facility in Brisbane, Australia. AIMS: The specific aims of the survey were to identify (i) knowledge of the nutritional needs of aged care facility residents; (ii) mealtime practices; and (iii) attitudes towards mealtime practices and organisation. METHODS: A survey based on those used in other healthcare settings was completed by 76 staff members. The survey included questions about nutritional knowledge, opinions of the food service, frequency of feeding assistance provided and feeding assessment practices. RESULTS: Nutritional knowledge scores ranged from 1 to 9 of a possible 10, with a mean score of 4.67. While 76% of respondents correctly identified risk factors associated with malnutrition in nursing home residents, only 38% of participants correctly identified the need for increased protein and energy in residents with pressure ulcers, and just 15% exhibited correct knowledge of fluid requirements. Further, while nutritional assessment was considered an important part of practice by 83% of respondents, just 53% indicated that they actually carried out such assessments. Identified barriers to promoting optimal nutrition included insufficient time to observe residents (56%); being unaware of residents' feeding issues (46%); poor knowledge of nutritional assessments (44%); and unappetising appearance of food served (57%). CONCLUSION: An important step towards improving health and quality of life for residents of aged care facilities would be to enhance staff nutritional awareness and assessment skills. This should be carried out through increased attention to both preservice curricula and on-the-job training. IMPLICATIONS FOR PRACTICE: The residential facility staff surveyed demonstrated low levels of nutrition knowledge, which reflects findings from the international literature. This has implications for the provision of responsive care to residents of these facilities and should be explored further.},
 bibtype = {article},
 author = {Beattie, E and O'Reilly, M and Strange, E and Franklin, S and Isenring, E},
 journal = {International journal of older people nursing},
 number = {1}
}

Paper  doi  abstract   bibtex   

@article{chu_thermal_2014,
	title = {Thermal ablation of tumours: biological mechanisms and advances in therapy},
	volume = {14},
	copyright = {2014 Nature Publishing Group},
	issn = {1474-1768},
	shorttitle = {Thermal ablation of tumours},
	url = {https://www.nature.com/articles/nrc3672},
	doi = {10.1038/nrc3672},
	abstract = {Minimally invasive thermal ablation of tumours has become common since the advent of modern imaging. From the ablation of small, unresectable tumours to experimental therapies, percutaneous radiofrequency ablation, microwave ablation, cryoablation and irreversible electroporation have an increasing role in the treatment of solid neoplasms. This Opinion article examines the mechanisms of tumour cell death that are induced by the most common thermoablative techniques and discusses the rapidly developing areas of research in the field, including combinatorial ablation and immunotherapy, synergy with conventional chemotherapy and radiation, and the development of a new ablation modality in irreversible electroporation.},
	language = {en},
	number = {3},
	urldate = {2018-09-22},
	journal = {Nature Reviews Cancer},
	author = {Chu, Katrina F. and Dupuy, Damian E.},
	month = mar,
	year = {2014},
	note = {00506},
	keywords = {Ablation Techniques, Animals, Apoptosis, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Neoplasms, Surgery, Computer-Assisted},
	pages = {199--208},
}

@article{ wyller_conscientious_2014-1,
  title = {Conscientious objection and the liberal dilemma},
  volume = {134},
  issn = {0807-7096},
  doi = {10.4045/tidsskr.14.0221},
  language = {{ENG}, {NOR}},
  number = {5},
  journal = {Tidsskrift for den Norske laegeforening: tidsskrift for praktisk medicin, ny raekke},
  author = {Wyller, Vegard Bruun},
  month = {March},
  year = {2014},
  pmid = {24621904},
  pages = {504}
}

@article{taylor_all-cause_2013,
	title = {All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large {U}.{K}. primary care database},
	volume = {36},
	issn = {1935-5548},
	doi = {10.2337/dc12-1513},
	abstract = {OBJECTIVE: Middle-aged people with diabetes have been reported to have significantly higher risks of cardiovascular events than people without diabetes. However, recent falls in cardiovascular disease rates and more active management of risk factors may have abolished the increased risk. We aimed to provide an up-to-date assessment of the relative risks associated with type 2 diabetes of all-cause and cardiovascular mortality in middle-aged people in the U.K.
RESEARCH DESIGN AND METHODS: Using data from the General Practice Research Database, from 2004 to 2010, we conducted a cohort study of 87,098 people, 40-65 years of age at baseline, comparing 21,798 with type 2 diabetes and 65,300 without diabetes, matched on age, sex, and general practice. We produced hazard ratios (HRs) for mortality and compared rates of blood pressure testing, cholesterol monitoring, and use of aspirin, statins, and antihypertensive drugs. RESULTS People with type 2 diabetes, compared with people without diabetes, had a twofold increased risk of all-cause mortality (HR 2.07 [95\% CI 1.95-2.20], adjusted for smoking) and a threefold increased risk of cardiovascular mortality (3.25 [2.87-3.68], adjusted for smoking). Women had a higher relative risk than men, and people {\textless}55 years of age had a higher relative risk than those {\textgreater}55 years of age. Monitoring and medication rates were higher in those with diabetes (all P {\textless} 0.001).
CONCLUSIONS: Despite efforts to manage risk factors, administer effective treatments, and develop new therapies, middle-aged people with type 2 diabetes remain at significantly increased risk of death.},
	language = {eng},
	number = {8},
	journal = {Diabetes Care},
	author = {Taylor, Kathryn S. and Heneghan, Carl J. and Farmer, Andrew J. and Fuller, Alice M. and Adler, Amanda I. and Aronson, Jeffrey K. and Stevens, Richard J.},
	month = aug,
	year = {2013},
	pmid = {23435157},
	pmcid = {PMC3714501},
	keywords = {Adult, Cardiovascular Diseases, Cause of Death, Databases, Factual, Diabetes Mellitus, Type 2, Female, Great Britain, Humans, Male, Middle Aged, Risk, Sex Factors},
	pages = {2366--2371}
}

@article{ jit_key_2013,
  title = {Key issues for estimating the impact and cost-effectiveness of seasonal influenza vaccination strategies},
  volume = {9},
  issn = {2164-554X},
  doi = {10.4161/hv.23637},
  abstract = {Many countries have considered or are considering modifying their seasonal influenza immunization policies. Estimating the impact of such changes requires understanding the existing clinical and economic burden of influenza, as well as the potential impact of different vaccination options. Previous studies suggest that vaccinating clinical risk groups, health care workers, children and the elderly may be cost-effective. However, challenges in such estimation include: (1) potential cases are not usually virologically tested; (2) cases have non-specific symptoms and are rarely reported to surveillance systems; (3) endpoints for influenza proxies (such as influenza-like illness) need to be matched to case definitions for treatment costs, (4) disease burden estimates vary from year to year with strain transmissibility, virulence and prior immunity, (5) methods to estimate productivity losses due to influenza vary, (6) vaccine efficacy estimates from trials differ due to variation in subtype prevalence, vaccine match and case ascertainment, and (7) indirect (herd) protection from vaccination depends on setting-specific variables that are difficult to directly measure. Given the importance of knowing the impact of changes to influenza policy, such complexities need careful treatment using tools such as population-based trial designs, meta-analyses, time-series analyses and transmission dynamic models.},
  language = {eng},
  number = {4},
  journal = {Human Vaccines \& Immunotherapeutics},
  author = {Jit, Mark and Newall, Anthony T. and Beutels, Philippe},
  month = {April},
  year = {2013},
  pmid = {23357859},
  pmcid = {PMC3903903},
  keywords = {Cost-Benefit Analysis, Humans, Influenza Vaccines, Influenza, Human, Vaccination},
  pages = {834--840}
}

Website  abstract   bibtex   

@article{
 title = {Are forward and backward recall the same? A dual-task study of digit recall.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Adult,Attention,Attention: physiology,Executive Function,Executive Function: physiology,Humans,Mathematical Concepts,Mental Recall,Mental Recall: physiology,Space Perception,Space Perception: physiology,Young Adult},
 pages = {519-32},
 volume = {41},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/23263876},
 id = {99159d3e-5274-3213-bef9-d024aca4812a},
 created = {2016-01-12T16:04:56.000Z},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {There is some debate surrounding the cognitive resources underlying backward digit recall. Some researchers consider it to differ from forward digit recall due to the involvement of executive control, while others suggest that backward recall involves visuospatial resources. Five experiments therefore investigated the role of executive-attentional and visuospatial resources in both forward and backward digit recall. In the first, participants completed visuospatial 0-back and 2-back tasks during the encoding of information to be remembered. The concurrent tasks did not differentially disrupt performance on backward digit recall, relative to forward digit recall. Experiment 2 shifted concurrent load to the recall phase instead and, in this case, revealed a larger effect of both tasks on backward recall, relative to forwards recall, suggesting that backward recall may draw on additional resources during the recall phase and that these resources are visuospatial in nature. Experiments 3 and 4 then further investigated the role of visual processes in forward and backward recall using dynamic visual noise (DVN). In Experiment 3, DVN was presented during encoding of information to be remembered and had no effect upon performance. However, in Experiment 4, it was presented during the recall phase, and the results provided evidence of a role for visual imagery in backward digit recall. These results were replicated in Experiment 5, in which the same list length was used for forward and backward recall tasks. The findings are discussed in terms of both theoretical and practical implications.},
 bibtype = {article},
 author = {St Clair-Thompson, H. L. and Allen, R. J.},
 journal = {Memory & cognition},
 number = {4}
}

@article{ anonymous_i_2013,
  title = {I refused to perform abortions: you don't have to sacrifice your integrity to get ahead},
  volume = {347},
  issn = {1756-1833},
  shorttitle = {I refused to perform abortions},
  language = {eng},
  journal = {{BMJ} (Clinical research ed.)},
  author = {Anonymous},
  year = {2013},
  pmid = {24277210},
  keywords = {Abortion, Legal, Gynecology, Humans, Obstetrics, Refusal to Treat},
  pages = {f7015}
}

@article{thompson_epidemiological_2013,
	title = {Epidemiological features and risk factors of {Salmonella} gastroenteritis in children resident in {Ho} {Chi} {Minh} {City}, {Vietnam}.},
	volume = {141},
	issn = {1469-4409 0950-2688},
	doi = {10.1017/S0950268812002014},
	abstract = {Non-typhoidal Salmonella are an important but poorly characterized cause of paediatric diarrhoea in developing countries. We conducted a hospital-based case-control study in children aged {\textless}5 years in Ho Chi Minh City to define the epidemiology and examine risk factors associated with Salmonella diarrhoeal infections. From 1419 diarrhoea cases and 571 controls enrolled between 2009 and  2010, 77 (54\%) diarrhoea cases were stool culture-positive for non-typhoidal Salmonella. Salmonella patients were more likely to be younger than controls (median age 10 and 12 months, respectively) [odds ratio (OR) 097; 95\% confidence  interval (CI) 094-099], to report a recent diarrhoeal contact (81\% cases, 18\% controls; OR 598, 95\% CI 18-204) and to live in a household with {\textgreater}2 children (cases 208\%, controls 102\%; OR 232, 95\% CI 12-47). Our findings indicate that Salmonella are an important cause of paediatric gastroenteritis in this setting and we suggest that transmission may occur through direct human contact in the home.},
	language = {eng},
	number = {8},
	journal = {Epidemiology and infection},
	author = {Thompson, C. N. and Phan, V. T. M. and Le, T. P. T. and Pham, T. N. T. and Hoang, L. P. and Ha, V. and Nguyen, V. M. H. and Pham, V. M. and Nguyen, T. V. and Cao, T. T. and Tran, T. T. N. and Nguyen, T. T. H. and Dao, M. T. and Campbell, J. I. and Nguyen, T. C. and Tang, C. T. and Ha, M. T. and Farrar, J. and Baker, S.},
	month = aug,
	year = {2013},
	pmid = {23010148},
	pmcid = {PMC3733064},
	keywords = {*Developing Countries, Bacterial Typing Techniques, Case-Control Studies, Child, Preschool, Diarrhea/*epidemiology/microbiology, Feces/microbiology, Female, Gastroenteritis/*epidemiology/microbiology, Humans, Infant, Male, Prevalence, Risk Factors, Salmonella Infections/*epidemiology/microbiology/transmission, Salmonella/*isolation \& purification, Surveys and Questionnaires, Urban Population, Vietnam/epidemiology},
	pages = {1604--1613},
}

@article{
 title = {Rates of medical errors and preventable adverse events among hospitalized children following implementation of a resident handoff bundle},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Boston,Child,Child, Hospitalized,Communication,Electronic Health Records,Female,Hospitals, Pediatric,Humans,Internship and Residency,Intervention Studies,Male,Medical Errors/prevention & control,Patient Admission,Patient Care Team,Patient Handoff/standards,Prospective Studies,Workload},
 pages = {2262-2270},
 volume = {310},
 month = {12},
 day = {4},
 city = {Division of General Pediatrics, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts2Doernbecher Children's Hospital, Oregon Health and Science University, Portland.},
 id = {018db06d-f7e0-3911-8657-5e153547e9fc},
 created = {2016-08-21T22:18:53.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 67732; GR: 1K12HS019456-01/HS/AHRQ HHS/United States; GR: T32 HP10018/PHS HHS/United States; GR: UL1TR000128/TR/NCATS NIH HHS/United States; JID: 7501160; CIN: JAMA. 2013 Dec 4;310(21):2255-6. PMID: 24302086; ppublish},
 folder_uuids = {4da8a58e-a2c5-4458-a19c-93e568b77eb4,4481d550-f7a1-48e7-874d-7663267b606b},
 private_publication = {false},
 abstract = {IMPORTANCE: Handoff miscommunications are a leading cause of medical errors. Studies comprehensively assessing handoff improvement programs are lacking. OBJECTIVE: To determine whether introduction of a multifaceted handoff program was associated with reduced rates of medical errors and preventable adverse events, fewer omissions of key data in written handoffs, improved verbal handoffs, and changes in resident-physician workflow. DESIGN, SETTING, AND PARTICIPANTS: Prospective intervention study of 1255 patient admissions (642 before and 613 after the intervention) involving 84 resident physicians (42 before and 42 after the intervention) from July-September 2009 and November 2009-January 2010 on 2 inpatient units at Boston Children's Hospital. INTERVENTIONS: Resident handoff bundle, consisting of standardized communication and handoff training, a verbal mnemonic, and a new team handoff structure. On one unit, a computerized handoff tool linked to the electronic medical record was introduced. MAIN OUTCOMES AND MEASURES: The primary outcomes were the rates of medical errors and preventable adverse events measured by daily systematic surveillance. The secondary outcomes were omissions in the printed handoff document and resident time-motion activity. RESULTS: Medical errors decreased from 33.8 per 100 admissions (95% CI, 27.3-40.3) to 18.3 per 100 admissions (95% CI, 14.7-21.9; P < .001), and preventable adverse events decreased from 3.3 per 100 admissions (95% CI, 1.7-4.8) to 1.5 (95% CI, 0.51-2.4) per 100 admissions (P = .04) following the intervention. There were fewer omissions of key handoff elements on printed handoff documents, especially on the unit that received the computerized handoff tool (significant reductions of omissions in 11 of 14 categories with computerized tool; significant reductions in 2 of 14 categories without computerized tool). Physicians spent a greater percentage of time in a 24-hour period at the patient bedside after the intervention (8.3%; 95% CI 7.1%-9.8%) vs 10.6% (95% CI, 9.2%-12.2%; P = .03). The average duration of verbal handoffs per patient did not change. Verbal handoffs were more likely to occur in a quiet location (33.3%; 95% CI, 14.5%-52.2% vs 67.9%; 95% CI, 50.6%-85.2%; P = .03) and private location (50.0%; 95% CI, 30%-70% vs 85.7%; 95% CI, 72.8%-98.7%; P = .007) after the intervention. CONCLUSIONS AND RELEVANCE: Implementation of a handoff bundle was associated with a significant reduction in medical errors and preventable adverse events among hospitalized children. Improvements in verbal and written handoff processes occurred, and resident workflow did not change adversely.},
 bibtype = {article},
 author = {Starmer, A J and Sectish, T C and Simon, D W and Keohane, C and McSweeney, M E and Chung, E Y and Yoon, C S and Lipsitz, S R and Wassner, A J and Harper, M B and Landrigan, C P},
 journal = {JAMA : the journal of the American Medical Association},
 number = {21}
}

Paper  doi  abstract   bibtex   

@article{finck_normalization_2013,
	title = {Normalization of mass cytometry data with bead standards},
	volume = {83},
	issn = {1552-4930},
	url = {onlinelibrary.wiley.com/doi/10.1002/cyto.a.22271/abstract},
	doi = {10.1002/cyto.a.22271},
	abstract = {Mass cytometry uses atomic mass spectrometry combined with isotopically pure reporter elements to currently measure as many as 40 parameters per single cell. As with any quantitative technology, there is a fundamental need for quality assurance and normalization protocols. In the case of mass cytometry, the signal variation over time due to changes in instrument performance combined with intervals between scheduled maintenance must be accounted for and then normalized. Here, samples were mixed with polystyrene beads embedded with metal lanthanides, allowing monitoring of mass cytometry instrument performance over multiple days of data acquisition. The protocol described here includes simultaneous measurements of beads and cells on the mass cytometer, subsequent extraction of the bead-based signature, and the application of an algorithm enabling correction of both short- and long-term signal fluctuations. The variation in the intensity of the beads that remains after normalization may also be used to determine data quality. Application of the algorithm to a one-month longitudinal analysis of a human peripheral blood sample reduced the range of median signal fluctuation from 4.9-fold to 1.3-fold.},
	language = {eng},
	number = {5},
	journal = {Cytometry. Part A: the journal of the International Society for Analytical Cytology},
	author = {Finck, Rachel and Simonds, Erin F and Jager, Astraea and Krishnaswamy, Smita and Sachs, Karen and Fantl, Wendy and Pe'er, Dana and Nolan, Garry P and Bendall, Sean C},
	month = may,
	year = {2013},
	pmid = {23512433},
	pmcid = {PMC3688049},
	keywords = {Algorithms, Flow Cytometry, Humans, Lanthanoid Series Elements, Leukocytes, Mononuclear, Mass Spectrometry, Materials Testing, Microspheres, Polystyrenes, quality control, Reference Values, Software},
	pages = {483--494}
}

Website  abstract   bibtex   

@article{
 title = {Dynamic data during hypotensive episode improves mortality predictions among patients with sepsis and hypotension.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {80 and over,Adult,Aged,Algorithms,Cohort Studies,Comorbidity,Critical Illness,Critical Illness: mortality,Female,Great Britain,Hospital Mortality,Hospital Mortality: trends,Humans,Hypotension,Hypotension: mortality,Intensive Care Units,Male,Middle Aged,Outcome Assessment (Health Care),Predictive Value of Tests,Prognosis,Retrospective Studies,Sepsis,Sepsis: mortality},
 pages = {954-62},
 volume = {41},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3609896&tool=pmcentrez&rendertype=abstract},
 month = {4},
 publisher = {NIH Public Access},
 id = {95d7042f-e668-3f25-aeb3-4f00b98dda28},
 created = {2016-03-29T18:26:56.000Z},
 file_attached = {false},
 profile_id = {304786e8-5116-360a-80be-e62833097578},
 group_id = {d7b44578-07c1-3210-ae74-3bcd7f980767},
 last_modified = {2017-03-14T15:45:25.917Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Mayaud_Crit_Care_April_2013},
 source_type = {article},
 private_publication = {false},
 abstract = {OBJECTIVES: To determine if a prediction rule for hospital mortality using dynamic variables in response to treatment of hypotension in patients with sepsis performs better than current models.\n\nDESIGN: Retrospective cohort study.\n\nSETTING: All ICUs at a tertiary care hospital.\n\nPATIENTS: Adult patients admitted to ICUs between 2001 and 2007 of whom 2,113 met inclusion criteria and had sufficient data.\n\nINTERVENTIONS: None.\n\nMEASUREMENTS AND MAIN RESULTS: We developed a prediction algorithm for hospital mortality in patients with sepsis and hypotension requiring medical intervention using data from the Multiparameter Intelligent Monitoring in Intensive Care II. We extracted 189 candidate variables, including treatments, physiologic variables and laboratory values collected before, during, and after a hypotensive episode. Thirty predictors were identified using a genetic algorithm on a training set (n=1500) and validated with a logistic regression model on an independent validation set (n=613). The final prediction algorithm used included dynamic information and had good discrimination (area under the receiver operating curve=82.0%) and calibration (Hosmer-Lemeshow C statistic=10.43, p=0.06). This model was compared with Acute Physiology and Chronic Health Evaluation IV using reclassification indices and was found to be superior with an Net Reclassification Improvement of 0.19 (p<0.001) and an Integrated Discrimination Improvement of 0.09 (p<0.001).\n\nCONCLUSIONS: Hospital mortality predictions based on dynamic variables surrounding a hypotensive event is a new approach to predicting prognosis. A model using these variables has good discrimination and calibration and offers additional predictive prognostic information beyond established ones.},
 bibtype = {article},
 author = {Mayaud, Louis and Lai, Peggy S and Clifford, Gari D and Tarassenko, Lionel and Celi, Leo Anthony and Annane, Djillali},
 journal = {Critical Care Medicine},
 number = {4}
}

@article{ radua_new_2012,
  title = {A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps},
  volume = {27},
  issn = {1778-3585},
  doi = {10.1016/j.eurpsy.2011.04.001},
  abstract = {Meta-analyses are essential to summarize the results of the growing number of neuroimaging studies in psychiatry, neurology and allied disciplines. Image-based meta-analyses use full image information (i.e. the statistical parametric maps) and well-established statistics, but images are rarely available making them highly unfeasible. Peak-probability meta-analyses such as activation likelihood estimation (ALE) or multilevel kernel density analysis (MKDA) are more feasible as they only need reported peak coordinates. Signed-differences methods, such as signed differential mapping (SDM) build upon the positive features of existing peak-probability methods and enable meta-analyses of studies comparing patients with controls. In this paper we present a new version of SDM, named Effect Size SDM (ES-SDM), which enables the combination of statistical parametric maps and peak coordinates and uses well-established statistics. We validated the new method by comparing the results of an ES-SDM meta-analysis of studies on the brain response to fearful faces with the results of a pooled analysis of the original individual data. The results showed that ES-SDM is a valid and reliable coordinate-based method, whose performance might be additionally increased by including statistical parametric maps. We anticipate that ES-SDM will be a helpful tool for researchers in the fields of psychiatry, neurology and allied disciplines.},
  language = {eng},
  number = {8},
  journal = {European Psychiatry: The Journal of the Association of European Psychiatrists},
  author = {Radua, J. and Mataix-Cols, D. and Phillips, M. L. and El-Hage, W. and Kronhaus, D. M. and Cardoner, N. and Surguladze, S.},
  month = {November},
  year = {2012},
  pmid = {21658917},
  keywords = {Adult, Brain, Brain Mapping, Facial Expression, Humans, Magnetic Resonance Imaging, Neuroimaging, Neuropsychological Tests, Reproducibility of Results},
  pages = {605--611}
}

Website  abstract   bibtex   

@article{
 title = {Quantitative evaluation of white matter tract DTI parameter changes in gliomas using nonlinear registration.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Anisotropy,Brain Mapping,Brain Mapping: methods,Brain Neoplasms,Brain Neoplasms: pathology,Computer-Assisted,Diffusion Magnetic Resonance Imaging,Diffusion Magnetic Resonance Imaging: methods,Female,Glioma,Glioma: pathology,Humans,Image Interpretation,Male,Middle Aged},
 pages = {2309-15},
 volume = {60},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22387173},
 month = {5},
 day = {1},
 id = {52c453a0-39cf-3063-98b2-f969182bb93f},
 created = {2014-02-21T01:56:21.000Z},
 accessed = {2014-01-28},
 file_attached = {false},
 profile_id = {c9197201-0e1b-30a7-a154-39d024463beb},
 last_modified = {2017-03-16T10:25:05.903Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Diffusion tensor imaging (DTI) has been used extensively to investigate white matter architecture in the brain. In the context of neurological disease, quantification of DTI data sets enables objective characterisation of the associated pathological changes. The aim of this study is to propose a method of evaluating DTI parameter changes in gliomas in the internal capsule using nonlinear registration to delineate the white matter and enable quantitative assessment of DTI derived parameters. 20 patients selected pre-operatively with probable grade 2 or grade 3 glioma on structural MRI along with ten normal volunteers were included in this study. DTI fractional anisotropy (FA) maps were used to define a common segmented FA skeleton that was projected back onto the original individual FA maps. Objective segment classification as normal or abnormal was achieved by comparison to prediction intervals of FA and mean diffusivity (MD) defined in normal subjects. The internal capsules of each patient were segmented into 10 regions of interest (ROI) with 20 and 16 segments across the group having significantly increased or decreased FA and MD values respectively. Seven glioma patients had abnormal DTI parameters in the internal capsule. We show that the classification of tract segments was consistent with disruption, oedema or compression. The results suggest that this method could be used to detect changes in eloquent white matter tracts in individual patients.},
 bibtype = {article},
 author = {Miller, P and Coope, D and Thompson, G and Jackson, A and Herholz, K},
 journal = {NeuroImage},
 number = {4}
}

@article{looker_lumbar_2012-1,
	title = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: {United} {States}, 2005-2008},
	issn = {0083-1980},
	shorttitle = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area},
	abstract = {OBJECTIVE: This report presents bone measurement data from dual-energy X-ray absorptiometry scans of the lumbar spine and proximal femur for persons aged 8 years and over from the National Health and Nutrition Examination Survey (NHANES) 2005-2008.
METHODS: Means, standard deviations, and selected percentiles were calculated for the proximal femur and lumbar spine (total and subregions) by sex, race and ethnicity, and age. Smoothed mean total lumbar spine and femur neck bone mineral density (BMD) were plotted by age, sex, and race and ethnicity. Multiple regression was used to test for significant interactions and to calculate mean total lumbar spine and femur neck BMD after adjusting for age, sex, and race and ethnicity. Differences by sex, race and ethnicity, and age were summarized by calculating the percent difference in adjusted means.
RESULTS: Among scanned individuals, 11\% lacked total lumbar spine data due to invalid data for one or more lumbar vertebrae, and 4\% had invalid data for the proximal femur. Non-Hispanic black persons had 6\% higher total lumbar spine BMD and 9\%-10\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD and femur neck BMD did not differ between Mexican-American and non-Hispanic white persons in those under age 20. For those aged 20 and over, Mexican-American persons had 4\% lower total lumbar spine BMD but 1\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD was 8\%-17\% higher in females aged 8-15 compared with males of the same age. In the age group 16-49, mean total lumbar spine BMD was similar or slightly higher for females compared with males, but after age 50 it was 60\%-15\% lower for females compared with males. Mean femur neck BMD was 5\%-13\% lower for females than males in all age groups except 12-15.},
	language = {eng},
	number = {251},
	journal = {Vital and Health Statistics. Series 11, Data from the National Health Survey},
	author = {Looker, Anne C. and Borrud, Lori G. and Hughes, Jeffery P. and Fan, Bo and Shepherd, John A. and Melton, L. Joseph},
	month = mar,
	year = {2012},
	pmid = {24261130},
	keywords = {Absorptiometry, Photon, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bone Density, Child, Ethnic Groups, Female, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Nutrition Surveys, Regression Analysis, Sex Factors, United States, Young Adult},
	pages = {1--132}
}

@article{baracos_advances_2012,
	title = {Advances in the science and application of body composition measurement},
	volume = {36},
	issn = {1941-2444},
	doi = {10.1177/0148607111417448},
	language = {eng},
	number = {1},
	journal = {JPEN. Journal of parenteral and enteral nutrition},
	author = {Baracos, Vickie and Caserotti, Paolo and Earthman, Carrie P. and Fields, David and Gallagher, Dympna and Hall, Kevin D. and Heymsfield, Steven B. and Müller, Manfred J. and Rosen, Antonella Napolitano and Pichard, Claude and Redman, Leanne M. and Shen, Wei and Shepherd, John A. and Thomas, Diana},
	month = jan,
	year = {2012},
	pmid = {22235108},
	pmcid = {PMC4422066},
	keywords = {Absorptiometry, Photon, Acute Disease, Adipose Tissue, Aging, Body Composition, Chronic Disease, Dielectric Spectroscopy, Energy Metabolism, Humans, Magnetic Resonance Imaging, Metabolic Diseases, Models, Biological, Neoplasms},
	pages = {96--107}
}

@inproceedings{ yanzhao_research_2012,
  title = {Research of {Trustworthy} {Software} {System} in the {Network}},
  doi = {10.1109/PAAP.2012.47},
  abstract = {This paper first analyzes the credibility of human society issues, gives a credible model, revealing the essence of credibility, that man's morality, competence and confidentiality of three aspects. Based on these we analyze the credible issue of the network software, and establish the credibility of a general model and a utility model, give the definition of software credibility and credible degree, and propose the key attributes or evidence of the software credibility: the identity evidence, the evidence of the basic norms and the capability. And finally with the general reliability, anti-aggressive and the basic norms to measure the software credibility is proposed. The software faults and vulnerabilities are classified in this paper, and an assessment method and a credibility formula to the credibility of the network software are given.},
  booktitle = {2012 {Fifth} {International} {Symposium} on {Parallel} {Architectures}, {Algorithms} and {Programming} ({PAAP})},
  author = {Yanzhao, Liu and Lei, Zhang and Ping, Luo and Yao, Yao},
  month = {December},
  year = {2012},
  keywords = {Ethics, Humans, Security, Software metrics, Software systems, _done, anti-aggressive, competence, confidentiality, credibility, credible degree, general model credibility essence, general reliability, human society issues, methods of measurement and evaluation, morality, network software, network software credible issue, security of data, software credibility measurement, software fault classification, software fault tolerance, software reliability, software vulnerability classification, trustworthy software system, utility model credibility},
  pages = {287--294}
}

@article{ drackley_effect_2012,
  title = {Effect of massage therapy for postsurgical mastectomy recipients},
  volume = {16},
  issn = {1538-067X},
  doi = {10.1188/12.CJON.121-124},
  abstract = {This quality improvement pilot study evaluated the effect of massage therapy on pain, anxiety, and overall well-being in women who received mastectomies at a busy hospital practice. Participants reported a significant reduction in pain, stress, and muscle tension, as well as an increase in relaxation. Oncology nurses should consider the feasibility of massage therapy as a valuable nonpharmcologic pain management strategy.},
  language = {eng},
  number = {2},
  journal = {Clinical Journal of Oncology Nursing},
  author = {Drackley, Nancy L. and Degnim, Amy C. and Jakub, James W. and Cutshall, Susanne M. and Thomley, Barbara S. and Brodt, Julie K. and Vanderlei, Laura K. and Case, Jane K. and Bungum, Lisa D. and Cha, Stephen S. and Bauer, Brent A. and Boughey, Judy C.},
  month = {April},
  year = {2012},
  pmid = {22459520},
  keywords = {Anxiety, Breast Neoplasms, Evidence-Based Nursing, Female, Humans, Massage, Mastectomy, Pain, Patient Satisfaction, Pilot Projects},
  pages = {121--124}
}

@article{spoendlin_study_2012,
	title = {A study on the epidemiology of rosacea in the {U}.{K}},
	volume = {167},
	issn = {1365-2133},
	doi = {10.1111/j.1365-2133.2012.11037.x},
	abstract = {BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09\% to 22\%. To our knowledge, incidence rates have not been quantified before.
OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5\% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80\% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8\% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95\% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.},
	language = {eng},
	number = {3},
	journal = {The British Journal of Dermatology},
	author = {Spoendlin, J. and Voegel, J. J. and Jick, S. S. and Meier, C. R.},
	month = sep,
	year = {2012},
	pmid = {22564022},
	keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alcohol Drinking, Child, Child, Preschool, Diagnosis, Differential, Epidemiologic Methods, Female, Great Britain, Humans, Infant, Life Style, Male, Middle Aged, Rosacea, Smoking, Young Adult, incidence},
	pages = {598--605}
}

@article{trigo_review_2012,
	title = {A review on digital {ECG} formats and the relationships between them},
	volume = {16},
	issn = {1558-0032},
	doi = {10.1109/TITB.2011.2176955},
	abstract = {A plethora of digital ECG formats have been proposed and implemented. This heterogeneity hinders the design and development of interoperable systems and entails critical integration issues for the healthcare information systems. This paper aims at performing a comprehensive overview on the current state of affairs of the interoperable exchange of digital ECG signals. This includes 1) a review on existing digital ECG formats, 2) a collection of applications and cardiology settings using such formats, 3) a compilation of the relationships between such formats, and 4) a reflection on the current situation and foreseeable future of the interoperable exchange of digital ECG signals. The objectives have been approached by completing and updating previous reviews on the topic through appropriate database mining. 39 digital ECG formats, 56 applications, tools or implantation experiences, 47 mappings/converters, and 6 relationships between such formats have been found in the literature. The creation and generalization of a single standardized ECG format is a desirable goal. However, this unification requires political commitment and international cooperation among different standardization bodies. Ongoing ontology-based approaches covering ECG domain have recently emerged as a promising alternative for reaching fully fledged ECG interoperability in the near future.},
	language = {eng},
	number = {3},
	journal = {IEEE transactions on information technology in biomedicine: a publication of the IEEE Engineering in Medicine and Biology Society},
	author = {Trigo, Jesús Daniel and Alesanco, Alvaro and Martínez, Ignacio and García, José},
	month = may,
	year = {2012},
	pmid = {22128009},
	keywords = {Electrocardiography, Electronic Health Records, Humans, Information Systems, Signal Processing, Computer-Assisted, Telemedicine},
	pages = {432--444}
}

Paper  abstract   bibtex   

@article{
 title = {Complications associated with the treatment for spinal ependymomas.},
 type = {article},
 year = {2011},
 identifiers = {[object Object]},
 keywords = {Antineoplastic Agents,Antineoplastic Agents: adverse effects,Antineoplastic Agents: therapeutic use,Ependymoma,Ependymoma: epidemiology,Ependymoma: radiography,Ependymoma: therapy,Humans,Microsurgery,Microsurgery: adverse effects,Postoperative Complications,Postoperative Complications: epidemiology,Postoperative Complications: etiology,Postoperative Complications: radiography,Spinal Neoplasms,Spinal Neoplasms: epidemiology,Spinal Neoplasms: radiography,Spinal Neoplasms: therapy,Treatment Outcome},
 pages = {E13},
 volume = {31},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/21961857},
 month = {10},
 id = {6f050f7e-bedf-3314-9837-4ee8fc588558},
 created = {2013-09-11T03:07:32.000Z},
 accessed = {2013-09-10},
 file_attached = {true},
 profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-11-22T16:36:55.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Spinal cord ependymomas are rare neoplasms, comprising approximately 5% of all CNS tumors and 15% of all spinal cord tumors. Although surgery was once reserved for diagnosis alone, the evolution of surgical practices has elevated resection to the treatment of choice for these lesions. While technological advances continue to improve the capacity for gross-total resections and thus decrease the risk of recurrence, ependymoma spinal surgery still contains a variety of potential complications. The presence of neurological deficits and deterioration are not uncommonly associated with spinal cord ependymoma surgery, including sensory loss, dorsal column dysfunction, dysesthetic syndrome, and bowel and bladder dysfunction, particularly in the immediate postoperative period. Surgical treatment may also lead to wound complications and CSF leaks, with increased risk when radiotherapy has been involved. Radiation therapy may also predispose patients to radiation myelopathy and ultimately result in neurological damage. Additionally, resections of spinal ependymomas have been associated with postoperative spinal instability and deformities, particularly in the pediatric population. Despite the advances in microsurgical techniques and intraoperative cord monitoring modalities, there remain a number of serious complications related to the treatment of spinal ependymoma tumors. Identification and acknowledgment of these potential problems may assist in their prevention, early detection, and increased quality of life for patients afflicted with this disease.},
 bibtype = {article},
 author = {Nagasawa, Daniel T and Smith, Zachary a and Cremer, Nicole and Fong, Christina and Lu, Daniel C and Yang, Isaac},
 journal = {Neurosurgical Focus},
 number = {4}
}

@article{kelly_london_2011,
	title = {The {London} low emission zone baseline study},
	issn = {1041-5505},
	abstract = {On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter {\textless} or = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these suggested that the clearest signals of change were most likely to be measured near roadsides. The seven key areas were also likely to be of importance in carrying out a study to assess the health outcomes of an air quality intervention like the LEZ. Of the seven key areas, two already had monitoring sites with a full complement of equipment, four had monitoring sites that required upgrades of existing equipment, and one required a completely new installation. With the upgrades and new installations in place, fully ratified (verified) pollutant data (for PM10, PM with an aerodynamic diameter {\textless} or = 2.5 microm [PM2.5], nitrogen oxides [NOx], and ozone [O3] at all sites as well as for particle number, black smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites) were then collected for analysis. In addition, the seven key monitoring sites were supported by other sites in the London Air Quality Network (LAQN). From these, a robust set of baseline air quality data was produced. Data from automatic and manual traffic counters as well as automatic license-plate recognition cameras were used to compile detailed vehicle profiles. This enabled us to establish more precise associations between ambient pollutant concentrations and vehicle emissions. An additional goal of the study was to collect baseline PM data in order to test the hypothesis that changes in traffic densities and vehicle mixes caused by the LEZ would affect the oxidative potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM data set was the first to describe, in detail, the oxidative potential and metal content of the PM10 and PM2.5 of a major city's airshed. PM in London has considerable oxidative potential; clear differences in this measure were found from site to site, with evidence that the oxidative potential of both PM10 and PM2.5 at roadside monitoring sites was higher than at urban background locations. In the PM10 samples this increased oxidative activity appeared to be associated with increased concentrations of copper (Cu), barium (Ba), and bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. In the PM2.5 samples, no simple association could be seen, suggesting that other unmeasured components were driving the increased oxidative potential in this fraction of the roadside samples. These data suggest that two components were contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10 microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived for this baseline study confirmed key observations from a more limited spatial mapping exercise published in our earlier HEI report on the introduction of the London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In addition, the data set in the current report provided robust baseline information on the oxidative potential and metal content of PM found in the London airshed in the period before implementation of the LEZ; the finding that a proportion of the oxidative potential appears in the PM coarse mode and is apparently related to brake wear raises important issues regarding the nature of traffic management schemes. The final goal of this baseline study was to establish the feasibility, in ethical and operational terms, of using the U.K.'s electronic primary-care records to evaluate the effects of the LEZ on human health outcomes. Data on consultations and prescriptions were compiled from a pilot group of general practices (13 distributed across London, with 100,000 patients; 29 situated in the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals were obtained to link individual primary-care records to modeled NOx concentrations by means of post-codes. (To preserve anonymity, the postcodes were removed before delivery to the research team.) A wide range of NOx exposures was found across London as well as within and between the practices examined. Although we observed little association between NOx exposure and smoking status, a positive relationship was found between exposure and increased socioeconomic deprivation. The health outcomes we chose to study were asthma, chronic obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory tract infections, ischemic heart disease, heart failure, and atrial fibrillation. These outcomes were measured as prevalence or incidence. Their distributions by age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord with those reported in the epidemiology literature. No cross-sectional positive associations were found between exposure to NOx and any of the studied health outcomes; some associations were significantly negative. After the pilot study, a suitable primary-care database of London patients was identified, the General Practice Research Database responsible for giving us access to these data agreed to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring privacy of the records was agreed upon. The database included about 350,000 patients who had remained at the same address over the four-year period of the study. Power calculations for a controlled longitudinal analysis were then performed, indicating that for outcomes such as consultations for respiratory illnesses or prescriptions for asthma there was sufficient power to identify a 5\% to 10\% reduction in consultations for patients most exposed to the intervention compared with patients presumed to not be exposed to it. In conclusion, the work undertaken in this study provides a good foundation for future LEZ evaluations. Our extensive monitoring network, measuring a comprehensive set of pollutants (and a range of particle metrics), will continue to provide a valuable tool both for assessing the impact of LEZ regulations on air quality in London and for furthering understanding of the link between PM's composition and toxicity. Finally, we believe that in combination with our modeling of the predicted population-based changes in pollution exposure in London, the use of primary-care databases forms a sound basis and has sufficient statistical power for the evaluation of the potential impact of the LEZ on human health.},
	language = {eng},
	number = {163},
	journal = {Research Report (Health Effects Institute)},
	author = {Kelly, Frank and Armstrong, Ben and Atkinson, Richard and Anderson, H. Ross and Barratt, Ben and Beevers, Sean and Cook, Derek and Green, Dave and Derwent, Dick and Mudway, Ian and Wilkinson, Paul and {HEI Health Review Committee}},
	month = nov,
	year = {2011},
	pmid = {22315924},
	keywords = {Adolescent, Adult, Aged, Air Pollutants, Air Pollution, Child, Child, Preschool, Cross-Sectional Studies, Environmental Exposure, Environmental Monitoring, Female, Health Status, Humans, Infant, London, Longitudinal Studies, Male, Metals, Middle Aged, Nitrogen Oxides, Particulate Matter, Pilot Projects, Primary Health Care, Small-Area Analysis, Smoking, Socioeconomic Factors, Vehicle Emissions, Young Adult},
	pages = {3--79}
}

@article{mehta_using_2011,
	title = {Using phylogeography to characterize the origins of the {HIV}-1 subtype {F} epidemic in {Romania}},
	volume = {11},
	issn = {1567-7257},
	doi = {10.1016/j.meegid.2011.03.009},
	abstract = {BACKGROUND: During the late 1980s and early 1990s, an estimated 10,000 Romanian children were infected with HIV-1 subtype F nosocomially through contaminated needles and blood transfusions. However, the geographic source and origins of this epidemic remain unclear.
METHODS: Here we used phylogenetic inference and "relaxed" molecular clock dating analysis to further characterize the Romanian HIV-1 subtype F epidemic.
RESULTS: These analyses revealed a major lineage of Romanian HIV sequences consisting nearly entirely of virus sampled from adolescents and children and a distinct cluster that included a much higher ratio of adult sequences. Divergence time estimates inferred the time of most recent common ancestor of subtype F1 sequences to be 1973 (1966-1980) and for all Angolan sequences to 1975 (1968-1980). The most common ancestor of the Romanian sequences was dated to 1978 (1972-1983) with pediatric and adolescent sequences interspersed throughout the lineage. The phylogenetic structure of the entire subtype F epidemic suggests that multiple introductions of subtype F into Romania occurred either from the Angolan epidemic or from more distant ancestors. Since the historical records note that the Romanian pediatric epidemic did not begin until the late 1980s, the inferred time of most recent common ancestor of the Romanian lineage of 1978 suggests that there were multiple introductions of subtype F occurred into the pediatric population from HIV already circulating in Romania.
CONCLUSIONS: Analysis of the subtype F HIV-1 epidemic in an historical context allows for a deeper appreciation of how the HIV pandemic has been influenced by socio-political events.},
	language = {eng},
	number = {5},
	journal = {Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases},
	author = {Mehta, Sanjay R. and Wertheim, Joel O. and Delport, Wayne and Ene, Luminita and Tardei, Gratiela and Duiculescu, Dan and Pond, Sergei L. Kosakovsky and Smith, Davey M.},
	month = jul,
	year = {2011},
	pmid = {21439403},
	pmcid = {PMC3104099},
	keywords = {Epidemics, Gene Expression Regulation, Viral, HIV Infections, HIV-1, Humans, Phylogeny, Phylogeography, Romania, pol Gene Products, Human Immunodeficiency Virus},
	pages = {975--979},
}

@article{kotz_incidence_2011,
	title = {Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in {England}, 2001 to 2005},
	volume = {127},
	issn = {1097-6825},
	doi = {10.1016/j.jaci.2010.11.021},
	abstract = {BACKGROUND: Previous descriptions of the epidemiology of peanut allergy have mainly been derived from small cross-sectional studies.
OBJECTIVE: To interrogate a large national research database to provide estimates for the incidence, prevalence, and trends of general practitioner (GP)-recorded diagnosis of peanut allergy in the English population.
METHODS: Version 10 of the QRESEARCH database was used with data from 2,958,366 patients who were registered with 422 United Kingdom general practices in the years 2001 to 2005. The primary outcome was a recording of clinician-diagnosed peanut allergy.
RESULTS: The age-sex standardized incidence rate of peanut allergy in 2005 was 0.08 per 1000 person-years (95\% CI, 0.07-0.08), and the prevalence rate was 0.51 per 1000 patients (95\% CI, 0.49-0.54). This translated into an estimated 4000 incident cases (95\% CI, 3500-4600) and 25,700 prevalent cases (95\% CI, 24,400-27,100) of GP-recorded diagnosis of peanut allergy in England in 2005. During the study period, the incidence rate of peanut allergy remained fairly stable, whereas the prevalence rate doubled. In those under 18 years of age, the crude lifetime prevalence rate was higher in males than females. A significant inverse relationship between prevalence and socioeconomic status was found.
CONCLUSION: These data on GP-recorded diagnosis of peanut allergy from a large general practice database suggest a much lower prevalence in peanut allergy than has hitherto been found. This difference may in part be explained by underrecording of peanut allergy in general practice. Further research is needed to assess the true frequency of peanut allergy in the population and whether there has been a true increase in recent years.},
	language = {eng},
	number = {3},
	journal = {The Journal of Allergy and Clinical Immunology},
	author = {Kotz, Daniel and Simpson, Colin R. and Sheikh, Aziz},
	month = mar,
	year = {2011},
	pmid = {21236479},
	keywords = {Adolescent, Adult, Child, Child, Preschool, England, Female, General Practitioners, Great Britain, Humans, Infant, Male, Medical Records, Peanut Hypersensitivity, Prevalence, incidence},
	pages = {623--630.e1}
}

Website  abstract   bibtex   

@article{
 title = {Individual determinants of research utilization by nurses: a systematic review update},
 type = {article},
 year = {2011},
 identifiers = {[object Object]},
 pages = {1},
 volume = {6},
 websites = {http://implementationscience.biomedcentral.com/articles/10.1186/1748-5908-6-1},
 month = {12},
 day = {5},
 id = {79bdc9c5-87dd-3725-9dda-cecef3e1b25f},
 created = {2018-01-17T18:09:47.357Z},
 file_attached = {false},
 profile_id = {369acd69-1fe7-313d-821e-cb7bbe1ddab2},
 group_id = {c58111b6-6088-3a92-94c9-4742fdd13d6f},
 last_modified = {2018-01-17T18:09:47.357Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Squires2011g},
 private_publication = {false},
 abstract = {BACKGROUND: Interventions that have a better than random chance of increasing nurses' use of research are important to the delivery of quality patient care. However, few reports exist of successful research utilization in nursing interventions. Systematic identification and evaluation of individual characteristics associated with and predicting research utilization may inform the development of research utilization interventions. OBJECTIVE: To update the evidence published in a previous systematic review on individual characteristics influencing research utilization by nurses. METHODS: As part of a larger systematic review on research utilization instruments, 12 online bibliographic databases were searched. Hand searching of specialized journals and an ancestry search was also conducted. Randomized controlled trials, clinical trials, and observational study designs examining the association between individual characteristics and nurses' use of research were eligible for inclusion. Studies were limited to those published in the English, Danish, Swedish, and Norwegian languages. A vote counting approach to data synthesis was taken. RESULTS: A total of 42,770 titles were identified, of which 501 were retrieved. Of these 501 articles, 45 satisfied our inclusion criteria. Articles assessed research utilization in general (n = 39) or kinds of research utilization (n = 6) using self-report survey measures. Individual nurse characteristics were classified according to six categories: beliefs and attitudes, involvement in research activities, information seeking, education, professional characteristics, and socio-demographic/socio-economic characteristics. A seventh category, critical thinking, emerged in studies examining kinds of research utilization. Positive relationships, at statistically significant levels, for general research utilization were found in four categories: beliefs and attitudes, information seeking, education, and professional characteristics. The only characteristic assessed in a sufficient number of studies and with consistent findings for the kinds of research utilization was attitude towards research; this characteristic had a positive association with instrumental and overall research utilization. CONCLUSIONS: This review reinforced conclusions in the previous review with respect to positive relationships between general research utilization and: beliefs and attitudes, and current role. Furthermore, attending conferences/in-services, having a graduate degree in nursing, working in a specialty area, and job satisfaction were also identified as individual characteristics important to research utilization. While these findings hold promise as potential targets of future research utilization interventions, there were methodological problems inherent in many of the studies that necessitate their findings be replicated in further research using more robust study designs and multivariate assessment methods.},
 bibtype = {article},
 author = {Squires, Janet E and Estabrooks, Carole A and Gustavsson, Petter and Wallin, Lars},
 journal = {Implementation Science}
}

@article{ wicclair_conscientious_2011,
  title = {Conscientious refusals by hospitals and emergency contraception},
  volume = {20},
  issn = {1469-2147},
  doi = {10.1017/S0963180110000691},
  language = {eng},
  number = {1},
  journal = {Cambridge quarterly of healthcare ethics: {CQ}: the international journal of healthcare ethics committees},
  author = {Wicclair, Mark R},
  month = {January},
  year = {2011},
  pmid = {21223617},
  keywords = {Adolescent, Adult, Catholicism, Child Abuse, Sexual, Choice Behavior, Conscience, Contraception, Postcoital, Contraceptives, Postcoital, Emergency Service, Hospital, Female, Humans, Personal Autonomy, Pregnancy, Pregnancy Tests, Prescription Drugs, Rape, Refusal to Treat, Sex Offenses, Young Adult},
  pages = {130--138}
}

Paper  Website  abstract   bibtex   

@article{
 title = {iqr: A Tool for the Construction of Multi-level Simulations of Brain and Behaviour.},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Access to Information,Animal,Animals,Behavior,Behavior: physiology,Brain,Brain: physiology,Computer Simulation,Humans,Insects,Internet,Memory,Memory: physiology,Models,Neurological,Neurons,Neurons: physiology,Robotics,Software,Synapses,Synapses: physiology,Time Factors,User-Computer Interface},
 pages = {113-34},
 volume = {8},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/20502987},
 publisher = {Humana Press Inc.},
 id = {59515ef3-1a82-3d32-b933-751e65c1b13e},
 created = {2016-02-18T20:36:44.000Z},
 file_attached = {true},
 profile_id = {666a093a-6015-3506-8b43-c65cadb20ea2},
 last_modified = {2017-03-09T23:31:28.082Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bernardet2010},
 source_type = {article},
 folder_uuids = {2e9f9bfc-4801-4871-9757-39a0ad79563e,79387ff2-9353-4bd0-8477-6c81b81f953f},
 abstract = {The brain is the most complex system we know of. Despite the wealth of data available in neuroscience, our understanding of this system is still very limited. Here we argue that an essential component in our arsenal of methods to advance our understanding of the brain is the construction of artificial brain-like systems. In this way we can encompass the multi-level organisation of the brain and its role in the context of the complete embodied real-world and real-time perceiving and behaving system. Hence, on the one hand, we must be able to develop and validate theories of brains as closing the loop between perception and action, and on the other hand as interacting with the real world. Evidence is growing that one of the sources of the computational power of neuronal systems lies in the massive and specific connectivity, rather than the complexity of single elements. To meet these challenges-multiple levels of organisation, sophisticated connectivity, and the interaction of neuronal models with the real-world-we have developed a multi-level neuronal simulation environment, iqr. This framework deals with these requirements by directly transforming them into the core elements of the simulation environment itself. iqr provides a means to design complex neuronal models graphically, and to visualise and analyse their properties on-line. In iqr connectivity is defined in a flexible, yet compact way, and simulations run at a high speed, which allows the control of real-world devices-robots in the broader sense-in real-time. The architecture of iqr is modular, providing the possibility to write new neuron, and synapse types, and custom interfaces to other hardware systems. The code of iqr is publicly accessible under the GNU General Public License (GPL). iqr has been in use since 1996 and has been the core tool for a large number of studies ranging from detailed models of neuronal systems like the cerebral cortex, and the cerebellum, to robot based models of perception, cognition and action to large-scale real-world systems. In addition, iqr has been widely used over many years to introduce students to neuronal simulation and neuromorphic control. In this paper we outline the conceptual and methodological background of iqr and its design philosophy. Thereafter we present iqr's main features and computational properties. Finally, we describe a number of projects using iqr, singling out how iqr is used for building a "synthetic insect".},
 bibtype = {article},
 author = {Bernardet, Ulysses and Verschure, Paul F.M.J.},
 journal = {Neuroinformatics},
 number = {2}
}

@article{hofmann_living_2010,
	title = {Living in the now: {Physiological} mechanisms to tolerate a rapidly changing environment.},
	volume = {72},
	journal = {Annual Review of Physiology},
	author = {Hofmann, G. E. and Todgham, A. E.},
	year = {2010},
	keywords = {disturbance, MCR, populations}
}

@article{giudice_clinical_2010,
	title = {Clinical practice. {Endometriosis}},
	volume = {362},
	issn = {1533-4406},
	doi = {10.1056/NEJMcp1000274},
	language = {eng},
	number = {25},
	journal = {The New England Journal of Medicine},
	author = {Giudice, Linda C.},
	month = jun,
	year = {2010},
	pmid = {20573927},
	pmcid = {PMC3108065},
	keywords = {Dysmenorrhea, Dyspareunia, Endometriosis, Female, Humans, Infertility, Female, Pelvic Pain},
	pages = {2389--2398}
}

@article{may_peripheral_2010,
	title = {Peripheral biomarkers of endometriosis: a systematic review},
	volume = {16},
	issn = {1460-2369},
	shorttitle = {Peripheral biomarkers of endometriosis},
	doi = {10.1093/humupd/dmq009},
	abstract = {BACKGROUND: Endometriosis is estimated to affect 1 in 10 women during the reproductive years. There is often delay in making the diagnosis, mainly due to the non-specific nature of the associated symptoms and the need to verify the disease surgically. A biomarker that is simple to measure could help clinicians to diagnose (or at least exclude) endometriosis; it might also allow the effects of treatment to be monitored. If effective, such a marker or panel of markers could prevent unnecessary diagnostic procedures and/or recognize treatment failure at an early stage.
METHODS: We used QUADAS (Quality Assessment of Diagnostic Accuracy Studies) criteria to perform a systematic review of the literature over the last 25 years to assess critically the clinical value of all proposed biomarkers for endometriosis in serum, plasma and urine.
RESULTS: We identified over 100 putative biomarkers in publications that met the selection criteria. We were unable to identify a single biomarker or panel of biomarkers that have unequivocally been shown to be clinically useful.
CONCLUSIONS: Peripheral biomarkers show promise as diagnostic aids, but further research is necessary before they can be recommended in routine clinical care. Panels of markers may allow increased sensitivity and specificity of any diagnostic test.},
	language = {eng},
	number = {6},
	journal = {Human Reproduction Update},
	author = {May, K. E. and Conduit-Hulbert, S. A. and Villar, J. and Kirtley, S. and Kennedy, S. H. and Becker, C. M.},
	month = dec,
	year = {2010},
	pmid = {20462942},
	pmcid = {PMC2953938},
	keywords = {Antibodies, Apoptosis, Biomarkers, Cell Adhesion, Cytokines, Endometriosis, Female, Glycoproteins, Hormones, Humans, Intercellular Signaling Peptides and Proteins, Leukocytes, Proteomics, Vascular Endothelial Growth Factor A},
	pages = {651--674}
}

Website  abstract   bibtex   

@article{
 title = {ERPs and neural oscillations during volitional supporession of memory retrieval},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Adolescent,Analysis of Variance,Association Learning,Association Learning: physiology,Biological Clocks,Biological Clocks: physiology,Brain,Brain Mapping,Brain: blood supply,Brain: physiology,Electroencephalography,Emotions,Emotions: physiology,Evoked Potentials,Evoked Potentials: physiology,Female,Humans,Image Processing, Computer-Assisted,Magnetic Resonance Imaging,Male,Mental Recall,Mental Recall: physiology,Oxygen,Oxygen: blood,Photic Stimulation,Reaction Time,Visual Perception,Young Adult},
 pages = {1-10},
 volume = {25},
 websites = {http://www.mitpressjournals.org/doi/abs/10.1162/jocn_a_00418#.Vgcwxo9Viko},
 month = {10},
 publisher = {MIT Press55 Hayward Street, Cambridge, MA 02142-1315USAjournals-info@mit.edu},
 day = {28},
 id = {9e3549f7-2c0d-33e4-84d8-bab5eb144557},
 created = {2015-09-27T00:17:34.000Z},
 accessed = {2015-09-26},
 file_attached = {false},
 profile_id = {50a856f4-e41b-3395-a32c-35f3a97eb9f9},
 group_id = {1d7f53de-0a60-3d99-b9ab-c9b479ac932e},
 last_modified = {2015-11-28T00:03:58.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Depue2010m},
 language = {en},
 abstract = {Although investigations of memory and the dynamics of ERP components and neural oscillations as assessed through EEG have been well utilized, little research into the volitional nature of suppression over memory retrieval have used these methods. Oscillation analyses conducted on the Think/No-Think (TNT) task and volitional suppression of retrieval are of interest to broaden our knowledge of neural oscillations associated not only during successful memory retrieval but also when retrieval is unwanted or suppressed. In the current study, we measured EEG during a TNT task and performed ERP and EEG spectral power band analyses. ERP results replicated other researchers' observations of increases in 500-800 msec parietal effects for items where retrieval was instructed to be elaborated compared with being suppressed. Furthermore, EEG analyses indicated increased alpha (8-12 Hz) and theta (3-8 Hz) oscillations across parietal electrodes for items that were instructed to be suppressed versus those to be elaborated. Additionally, during the second half of the experiment (after repeated attempts at control), increases in theta oscillations were found across both frontal and parietal electrodes for items that were instructed to be suppressed and that were ultimately forgotten versus those ultimately remembered. Increased alpha power for items that were instructed to be suppressed versus elaborated may indicate reductions of retrieval attempts or lack of retrieval success. Increased theta power for items that were instructed to be suppressed versus elaborated may indicate increased or prolonged cognitive control to monitor retrieval events.},
 bibtype = {article},
 author = {Depue, Brendan Eliot and Ketz, Nick and Mollison, Matthew V and Nyhus, Erika and Banich, Marie T and Curran, Tim},
 journal = {Journal of Cognitive Neuroscience},
 number = {10}
}

@article{hippisley-cox_individualising_2010,
	title = {Individualising the risks of statins in men and women in {England} and {Wales}: population-based cohort study},
	volume = {96},
	issn = {1468-201X},
	shorttitle = {Individualising the risks of statins in men and women in {England} and {Wales}},
	doi = {10.1136/hrt.2010.199034},
	abstract = {OBJECTIVE: To derive and validate risk algorithms so that the risks of four clinical outcomes associated with statin use can be estimated for individual patients.
DESIGN: Prospective open cohort study using routinely collected data from 368 QResearch general practices in England and Wales to develop the scores. The scores were validated using two separate sets of practices-188 separate QResearch practices and 364 practices contributing to the THIN database.
SUBJECTS: In the QResearch derivation cohort 225 922 new users of statins and 1 778 770 non-users of statins were studied. In the QResearch validation cohort 118 372 statin users and 877 812 non-users of statins were studied. In the THIN validation cohort, we studied 282 056 statin users and 1 923 840 non-users of statins were studied.
METHODS: Cox proportional hazards models in the derivation cohort to derive risk equations. Measures of calibration and discrimination in both validation cohorts.
OUTCOMES: 5-Year risk of moderate/serious myopathic events; moderate/serious liver dysfunction; acute renal failure and cataract.
RESULTS: The performance of three of the risk prediction algorithms in the THIN cohort was very good. For example, in women, the algorithm for moderate/serious myopathy explained 42.15\% of the variation. The corresponding D statistics was 1.75. The acute renal failure algorithm explained 59.62\% of the variation (D statistic=2.49). The cataract algorithm explained 59.14\% of the variation (D statistic=2.46). The algorithms to predict moderate/severe liver dysfunction only explained 15.55\% of the variation (D statistics=0.89). The performance of each algorithm was similar for both sexes when tested on the QResearch validation cohort.
CONCLUSIONS: The algorithms to predict acute renal failure, moderate/serious myopathy and cataract could be used to identify patients at increased risk of these adverse effects enabling patients to be monitored more closely. Further research is needed to develop a better algorithm to predict liver dysfunction.},
	language = {eng},
	number = {12},
	journal = {Heart (British Cardiac Society)},
	author = {Hippisley-Cox, Julia and Coupland, Carol},
	month = jun,
	year = {2010},
	pmid = {20489220},
	keywords = {Acute Kidney Injury, Adult, Aged, Aged, 80 and over, Algorithms, Body Mass Index, Cataract, Drug-Induced Liver Injury, England, Epidemiologic Methods, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Muscular Diseases, Wales},
	pages = {939--947}
}

@article{benschop_interventions_2010,
	title = {Interventions for women with endometrioma prior to assisted reproductive technology},
	issn = {1469-493X},
	doi = {10.1002/14651858.CD008571.pub2},
	abstract = {BACKGROUND: Endometriomata are cysts of endometriosis in the ovaries. As artificial reproductive technology (ART) cycles involve oocyte pickup from the ovaries, endometriomata may interfere with the outcome of ART.
OBJECTIVES: To determine the effectiveness and safety of surgery, medical treatment, combination therapy or no treatment for improving reproductive outcomes among women with endometriomata, prior to undergoing ART cycles.
SEARCH STRATEGY: The review authors searched: Cochrane Menstrual Disorders and Subfertility Group Specialised Register of trials, CENTRAL (The Cochrane Library), EMBASE, MEDLINE, PubMed, PsycINFO, CINAHL, DARE, trial registers for ongoing and registered trials, citation indexes, conference abstracts on the ISI Web of Knowledge, Clinical Study Results, OpenSIGLE (July 2010) and handsearched Fertility and Sterility (2008 to 2010).
SELECTION CRITERIA: Randomised controlled trials of any medical, surgical or combination therapy or expectant management for endometriomata prior to ART.
DATA COLLECTION AND ANALYSIS: The trials were independently identified and assessed for risk of bias by two authors. The authors of the trials that were potentially eligible for inclusion were contacted for additional information. Outcomes were expressed as Peto odds ratios and mean differences (MD).
MAIN RESULTS: Eleven trials were identified of which seven were excluded and four with 312 participants were included.No trial reported live birth outcomes. One trial compared gonadotropin-releasing hormone (GnRH) agonist with GnRH antagonist. There was no evidence of a difference for clinical pregnancy rate (CPR), however the number of mature oocytes retrieved (NMOR) was greater with GnRH agonists (MD -1.60, 95\% CI -2.44 to -0.76) and the ovarian response was increased (estradiol (E2) levels on day of human chorionic gonadotropin (hCG) injection) (MD -456.30, 95\% CI -896.06 to -16.54).Surgery (aspiration or cystectomy) versus expectant management (EM) showed no evidence of a benefit for clinical pregnancy with either technique. Aspiration was associated with greater NMOR (MD 0.50, 95\% CI 0.02 to 0.98) and increased ovarian response (E2 levels on day of hCG injection) (MD 685.3, 95\% CI 464.50 to 906.10) compared to EM.Cystectomy was associated with a decreased ovarian response to controlled ovarian hyperstimulation (COH) (MD -510.00, 95\% CI -676.62 to -343.38); no evidence of an effect on the NMOR compared to EM. Aspiration versus cystectomy showed no evidence of a difference in CPR or the NMOR.
AUTHORS' CONCLUSIONS: There was no evidence of an effect on reproductive outcomes in any of the four included trials. Further RCTs of management of endometrioma in women undergoing ART are required.},
	language = {eng},
	number = {11},
	journal = {The Cochrane Database of Systematic Reviews},
	author = {Benschop, Laura and Farquhar, Cindy and van der Poel, Nicolien and Heineman, Maas Jan},
	year = {2010},
	pmid = {21069706},
	keywords = {Endometriosis, Female, Gonadotropin-Releasing Hormone, Humans, Infertility, Female, Ovarian Hyperstimulation Syndrome, Pregnancy, Randomized Controlled Trials as Topic, Reproductive Techniques, Assisted, Sperm Injections, Intracytoplasmic},
	pages = {CD008571}
}

@article{clifford_artificial_2010,
	title = {An artificial vector model for generating abnormal electrocardiographic rhythms},
	volume = {31},
	issn = {1361-6579},
	doi = {10.1088/0967-3334/31/5/001},
	abstract = {We present generalizations of our previously published artificial models for generating multi-channel ECG to provide simulations of abnormal cardiac rhythms. Using a three-dimensional vectorcardiogram (VCG) formulation, we generate the normal cardiac dipole for a patient using a sum of Gaussian kernels, fitted to real VCG recordings. Abnormal beats are specified either as perturbations to the normal dipole or as new dipole trajectories. Switching between normal and abnormal beat types is achieved using a first-order Markov chain. Probability transitions can be learned from real data or modeled by coupling to heart rate and sympathovagal balance. Natural morphology changes from beat-to-beat are incorporated by varying the angular frequency of the dipole as a function of the inter-beat (RR) interval. The RR interval time series is generated using our previously described model whereby time- and frequency-domain heart rate (HR) and heart rate variability characteristics can be specified. QT-HR hysteresis is simulated by coupling the Gaussian kernels associated with the T-wave in the model with a nonlinear factor related to the local HR (determined from the last n RR intervals). Morphology changes due to respiration are simulated by introducing a rotation matrix couple to the respiratory frequency. We demonstrate an example of the use of this model by simulating HR-dependent T-wave alternans (TWA) with and without phase-switching due to ectopy. Application of our model also reveals previously unreported effects of common TWA estimation methods.},
	language = {eng},
	number = {5},
	journal = {Physiological Measurement},
	author = {Clifford, Gari D. and Nemati, Shamim and Sameni, Reza},
	month = may,
	year = {2010},
	pmid = {20308774},
	pmcid = {PMC2927500},
	keywords = {Arrhythmias, Cardiac, Electrocardiography, Heart Rate, Humans, Models, Cardiovascular},
	pages = {595--609}
}

@article{ cilliers_pyridoxal-5-phosphate_2010,
  title = {Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid},
  volume = {99},
  issn = {1651-2227},
  doi = {10.1111/j.1651-2227.2010.01696.x},
  abstract = {AIM: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens.
METHODS: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements.
RESULTS: Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p {\textless} 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations ({\textless}6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004).
CONCLUSION: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.},
  language = {eng},
  number = {5},
  journal = {Acta Paediatrica (Oslo, Norway: 1992)},
  author = {Cilliers, K. and Labadarios, D. and Schaaf, H. S. and Willemse, M. and Maritz, J. S. and Werely, C. J. and Hussey, G. and Donald, P. R.},
  month = {May},
  year = {2010},
  pmid = {20146723},
  keywords = {AIDS-Related Opportunistic Infections, Adolescent, Antitubercular Agents, Child, Child, Preschool, Female, Genotype, HIV Infections, Humans, Infant, Isoniazid, Male, Pyridoxal Phosphate, South Africa, Tuberculosis},
  pages = {705--710}
}

Paper  Website  abstract   bibtex   

@article{
 title = {mhFLIM: Resolution of heterogeneous fluorescence decays in widefield lifetime microscopy},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Algorithms,Calibration,Cell Line,Coloring Agents,Coloring Agents: chemistry,Energy-Transfer,Flim,Fluorescence,Fourier Analysis,Frequency-Domain,Humans,Imaging Microscopy,Living Cells,Microscopy,Microscopy: instrumentation,Microscopy: methods,Phase,Solutions,System,Time Factors,Tumor},
 pages = {1557-1570},
 volume = {17},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19188985,http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=000263432400044,file://localhost/Users/cfk23/Documents/Papers/2009/Schlachter/Opt Express 2009 Schlachter.pdf,papers://5b342310-4c1b-4925-bbf8-38f14091331d/Paper/p51},
 month = {1},
 day = {2},
 city = {Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1RA, England},
 id = {7e30e62c-faaf-31b1-beb4-0479345bce7d},
 created = {2010-07-07T09:21:00.000Z},
 file_attached = {true},
 profile_id = {a836303d-69f8-302f-a6cc-6bab5a6094d9},
 last_modified = {2013-11-12T12:24:30.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 abstract = {Frequency-domain fluorescence lifetime imaging microscopy (FD-FLIM) is a fast and accurate way of measuring fluorescence lifetimes in widefield microscopy. However, the resolution of multiple exponential fluorescence decays has remained beyond the reach of most practical FD-FLIM systems. In this paper we describe the implementation of FD-FLIM using a 40MHz pulse train derived from a supercontinuum source for excitation. The technique, which we term multi-harmonic FLIM (mhFLIM), makes it possible to accurately resolve biexponential decays of fluorophores without any a priori information. The system's performance is demonstrated using a mixture of spectrally similar dyes of known composition and also on a multiply-labeled biological sample. The results are compared to those obtained from time correlated single photon counting (TCSPC) microscopy and a good level of agreement is achieved. We also demonstrate the first practical application of an algorithm derived by G. Weber [1] for analysing mhFLIM data. Because it does not require nonlinear minimisation, it offers potential for realtime analysis during acquisition. (C) 2009 Optical Society of America},
 bibtype = {article},
 author = {Schlachter, S and Elder, undefined and Esposito, undefined and Kaminski, undefined and Frank, undefined and Geest, Van and Elder, a D and Esposito, A and Kaminski, G S and Frank, J H and van Geest, L K and Kaminski, C F},
 journal = {Optics Express},
 number = {3}
}

@inproceedings{haddadin_dlr_2009-1,
	title = {The "{DLR} {Crash} {Report}": {Towards} a standard crash-testing protocol for robot safety - {Part} {I}: {Results}},
	shorttitle = {The \#x201C;{DLR} {Crash} {Report} \#x201D;},
	doi = {10.1109/ROBOT.2009.5152602},
	abstract = {After analyzing fundamental impact characteristics of robot-human collisions in our previous work, the intention in the present paper is to augment existing knowledge in this field, verify previously given statements with standardized equipment of the German Automobile Club (ADAC), and provide a crash-test report for robots in general. Various new insights are achieved and a systematic and extensive set of data is provided. The presented work is divided into two papers. The main purpose of Part I is to give, similarly to reports known from the automobile world1, a fact based and result oriented view on our newest robot crash-test experiments. In Part II detailed discussions of the results listed in the present paper and recommendations towards a standard crash-test protocol for robot safety are carried out.},
	booktitle = {2009 {IEEE} {International} {Conference} on {Robotics} and {Automation}},
	author = {Haddadin, S. and Albu-Schaffer, A. and Frommberger, M. and Rossmann, J. and Hirzinger, G.},
	month = may,
	year = {2009},
	keywords = {Automobiles, Clamps, Computer crashes, Contacts, Humans, Injuries, Protocols, Robotics and automation, Robots, Safety},
	pages = {272--279}
}

@article{bilimoria_national_2009,
	title = {National assessment of melanoma care using formally developed quality indicators},
	volume = {27},
	issn = {1527-7755},
	doi = {10.1200/JCO.2008.20.9965},
	abstract = {PURPOSE: There is considerable variation in the quality of cancer care delivered in the United States. Assessing care by using quality indicators could help decrease this variability. The objectives of this study were to formally develop valid quality indicators for melanoma and to assess hospital-level adherence with these measures in the United States.
METHODS: Quality indicators were identified from available literature, consensus guidelines, and melanoma experts. Thirteen experts ranked potential measures for validity on the basis of the RAND/University of California, Los Angeles Appropriateness Methodology. Adherence with individual valid indicators and a composite measure of all indicators were assessed at 1,249 Commission on Cancer hospitals by using the National Cancer Data Base (NCDB; 2004 through 2005).
RESULTS: Of 55 proposed quality indicators, 26 measures (47\%) were rated as valid. These indicators assessed structure (n = 1), process (n = 24), and outcome (n = 1). Of the 26 measures, 10 are readily assessable by using cancer registry data. Adherence with valid indicators ranged from 11.8\% to 96.5\% at the patient level and 3.7\% to 83.0\% at the hospital level. (Adherence required that {\textgreater}OR= 90\% of patients at a hospital receive concordant care.) Most hospitals were adherent with 50\% or fewer of the individual indicators (median composite score, five; interquartile range, four to seven). Adherence was higher for diagnosis and staging measures and was lower for treatment indicators.
CONCLUSION: There is considerable variation in the quality of melanoma care in the United States. By using these formally developed quality indicators, hospitals can assess their adherence with current melanoma care guidelines through feedback mechanisms from the NCDB and can better direct quality improvement efforts.},
	language = {eng},
	number = {32},
	journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
	author = {Bilimoria, Karl Y. and Raval, Mehul V. and Bentrem, David J. and Wayne, Jeffrey D. and Balch, Charles M. and Ko, Clifford Y.},
	month = nov,
	year = {2009},
	pmid = {19826131},
	keywords = {Databases, Factual, Delivery of Health Care, Humans, Melanoma, Outcome Assessment (Health Care), Quality Indicators, Health Care, United States},
	pages = {5445--5451}
}

@article{carabalona_brain-computer_2009,
	title = {Brain-computer interfaces and neurorehabilitation},
	volume = {145},
	issn = {0926-9630},
	abstract = {A brain-computer interface (BCI) directly uses brain-activity signals to allow users to operate the environment without any muscular activation. Thanks to this feature, BCI systems can be employed not only as assistive devices, but also as neurorehabilitation tools in clinical settings. However, several critical issues need to be addressed before using BCI in neurorehabilitation, issues ranging from signal acquisition and selection of the proper BCI paradigm to the evaluation of the affective state, cognitive load and system acceptability of the users. Here we discuss these issues, illustrating how a rehabilitation program can benefit from BCI sessions, and summarize the results obtained so far in this field. Also provided are experimental data concerning two important topics related to BCI usability in rehabilitation: the possibility of using dry electrodes for EEG acquisition, and the monitoring of psychophysiological effects during BCI tasks.},
	language = {eng},
	journal = {Studies in health technology and informatics},
	author = {Carabalona, Roberta and Castiglioni, Paolo and Gramatica, Furio},
	year = {2009},
	pmid = {19592793},
	keywords = {Brain, Humans, Nervous System Diseases, Self-Help Devices, Signal Processing, Computer-Assisted, User-Computer Interface, electrodes},
	pages = {160--176}
}

Paper  Website  abstract   bibtex   

@article{
 title = {PTSD and traumatic brain injury: folklore and fact?},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Brain Injuries,Brain Injuries: etiology,Brain Injuries: psychology,Diagnosis, Differential,Humans,Psychiatric Status Rating Scales,Stress Disorders, Post-Traumatic,Stress Disorders, Post-Traumatic: diagnosis,Stress Disorders, Post-Traumatic: psychology},
 pages = {1-5},
 volume = {22},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/18183503},
 month = {1},
 id = {906ed342-e280-33ac-99b1-a038613507db},
 created = {2017-06-01T08:23:59.557Z},
 accessed = {2012-03-09},
 file_attached = {true},
 profile_id = {b6efe121-8b29-3abc-9df5-2353a8d30e77},
 group_id = {32ad6c38-dd7d-39b9-9a71-86890e245b76},
 last_modified = {2017-06-01T08:23:59.761Z},
 tags = {anxiety,attention},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {A number of controversies and debates have arisen over the years surrounding the dual diagnosis of post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). Many of these have centred around the around the degree of protection provided by TBI against developing the disorder. The following is brief review of the literature in this area to help resolve some of these issues and to address a number of specific challenges which arise when working with this patient group.},
 bibtype = {article},
 author = {King, Nigel S},
 journal = {Brain injury : [BI]},
 number = {1}
}

@article{setakis_changes_2008,
	title = {Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib},
	volume = {59},
	issn = {0004-3591},
	doi = {10.1002/art.23925},
	abstract = {OBJECTIVE: To evaluate the impact of rofecoxib withdrawal on the characteristics of patients prescribed selective cyclooxygenase 2 (COX-2) inhibitors.
METHODS: The General Practice Research Database was used to identify patients age {\textgreater} or =18 years who were prescribed a selective COX-2 inhibitor. Various patient characteristics were noted at the start of therapy: age, sex, nonsteroidal antiinflammatory drug-related risk factors for upper gastrointestinal (GI) events, and the Framingham risk score for cardiovascular disease. Logistic regression was used to compare patients using selective COX-2 inhibitors before and after September 2004.
RESULT: The study population included 171,645 patients receiving selective COX-2 inhibitors. The number of users substantially increased over time until September 2004 and sharply declined thereafter. Approximately 80\% stopped selective COX-2 inhibitor therapy within 6 months. Patients receiving selective COX-2 inhibitors after September 2004 were younger and included more men compared with those receiving therapy before September 2004. There was no change before and after September 2004 in the proportion of patients with GI risk factors or high Framingham risk scores, after adjustment for age and sex. A correlation was found between presence of GI risk factors and high Framingham risk scores. Only 20\% of patients receiving selective COX-2 inhibitors had GI risk factors but low Framingham risk score, which did not change after September 2004.
CONCLUSION: There was no channeling in the usage of selective COX-2 inhibitors toward patients with a high risk of GI and low risk of cardiovascular disease following the withdrawal of rofecoxib.},
	language = {eng},
	number = {8},
	journal = {Arthritis and Rheumatism},
	author = {Setakis, E. and Leufkens, H. G. M. and van Staa, T. P.},
	month = aug,
	year = {2008},
	pmid = {18668614},
	keywords = {Adolescent, Adult, Aged, Cardiovascular Diseases, Cyclooxygenase 2 Inhibitors, Databases, Factual, Drug Prescriptions, Drug Utilization Review, Female, Gastrointestinal Diseases, Great Britain, Humans, Lactones, Logistic Models, Male, Middle Aged, Rheumatic Diseases, Risk Factors, Sulfones, incidence},
	pages = {1105--1111}
}

@article{cooke_mapping_2008,
	title = {Mapping of a novel susceptibility locus suggests a role for {MC3R} and {CTSZ} in human tuberculosis},
	volume = {178},
	issn = {1535-4970},
	doi = {10.1164/rccm.200710-1554OC},
	abstract = {RATIONALE: Tuberculosis remains a major cause of morbidity and mortality in the developing world. A better understanding of the mechanisms of disease protection could allow novel strategies to disease management and control.
OBJECTIVES: To identify human genomic loci with evidence of linkage to tuberculosis susceptibility and, within these loci, to identify individual genes influencing tuberculosis susceptibility.
METHODS: Affected sibling pair analysis in South African and Malawian populations. Independent case-control study in West Africa.
MEASUREMENTS AND MAIN RESULTS: Two novel putative loci for tuberculosis susceptibility are identified: chromosome 6p21-q23 and chromosome 20q13.31-33--the latter with the strongest evidence for any locus reported to date in human tuberculosis (single point LOD score of 3.1, P = 10(-4), with a maximum likelihood score [MLS] of 2.8). An independent, multistage genetic association study in West African populations mapped this latter region in detail, finding evidence that variation in the melanocortin 3 receptor (MC3R) and cathepsin Z (CTSZ) genes play a role in the pathogenesis of tuberculosis.
CONCLUSIONS: These results demonstrate how a genomewide approach to the complex phenotype of human tuberculosis can identify novel targets for further research.},
	language = {eng},
	number = {2},
	journal = {American Journal of Respiratory and Critical Care Medicine},
	author = {Cooke, Graham S. and Campbell, Sarah J. and Bennett, Steve and Lienhardt, Christian and McAdam, Keith P. W. J. and Sirugo, Giorgio and Sow, Oumou and Gustafson, Per and Mwangulu, Frank and van Helden, Paul and Fine, Paul and Hoal, Eileen G. and Hill, Adrian V. S.},
	month = jul,
	year = {2008},
	pmid = {18420963},
	pmcid = {PMC2643210},
	note = {00050 },
	keywords = {Africa, Western, African Continental Ancestry Group, Case-Control Studies, Cathepsin K, Cathepsin Z, Cathepsins, Genetic Linkage, Genetic Predisposition to Disease, Humans, Likelihood Functions, Malawi, Microsatellite Repeats, Pedigree, Polymorphism, Genetic, Receptor, Melanocortin, Type 3, Regression Analysis, Siblings, South Africa, Tuberculosis, Pulmonary},
	pages = {203--207},
}

Website  abstract   bibtex   

@article{
 title = {Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Animals,Antigens,Antineoplastic Agents,Antineoplastic Agents: pharmacology,B-Lymphocytes,B-Lymphocytes: pathology,Boronic Acids,Boronic Acids: pharmacology,CD20,CD20: analysis,CD27,CD27: analysis,Clone Cells,Clone Cells: drug effects,Clone Cells: pathology,Cyclophosphamide,Cyclophosphamide: analogs & derivatives,Cyclophosphamide: pharmacology,Dexamethasone,Dexamethasone: pharmacology,Drug Resistance,Humans,Inbred Strains,Mice,Multiple Myeloma,Multiple Myeloma: pathology,Neoplasm,Neoplastic Stem Cells,Neoplastic Stem Cells: drug effects,Neoplastic Stem Cells: pathology,Plasma Cells,Plasma Cells: drug effects,Plasma Cells: pathology,Pyrazines,Pyrazines: pharmacology,Syndecan-1,Syndecan-1: analysis,Thalidomide,Thalidomide: analogs & derivatives,Thalidomide: pharmacology,Tumor Stem Cell Assay},
 pages = {190-7},
 volume = {68},
 websites = {http://cancerres.aacrjournals.org/content/68/1/190.full},
 month = {1},
 day = {1},
 id = {494ed8c9-5c08-3403-8b42-0d004f92312a},
 created = {2016-06-24T20:49:19.000Z},
 accessed = {2014-11-18},
 file_attached = {false},
 profile_id = {954a987f-819f-3985-95a4-2991e0cf0552},
 group_id = {8440dcff-74cc-3783-aef7-fe2749cfc7ef},
 last_modified = {2016-06-24T20:49:19.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Matsui2008},
 abstract = {Many agents are active in multiple myeloma, but the majority of patients relapse. This clinical pattern suggests most cancer cells are eliminated, but cells with the clonogenic potential to mediate tumor regrowth are relatively chemoresistant. Our previous data suggested that CD138(+) multiple myeloma plasma cells cannot undergo long-term proliferation but rather arise from clonogenic CD138(neg) B cells. We compared the relative sensitivity of these distinct cell types to clinical antimyeloma agents and found that dexamethasone, lenadilomide, bortezomib, and 4-hydroxycyclophosphamide inhibited CD138(+) multiple myeloma plasma cells but had little effect on CD138(neg) precursors in vitro. We further characterized clonogenic multiple myeloma cells and stained cell lines using the Hoechst side population and Aldefluor assays. Each assay identified CD138(neg) cells suggesting that they possess high drug efflux capacity and intracellular drug detoxification activity. We also found that multiple myeloma cells expressing the memory B-cell markers CD20 and CD27 could give rise to clonogenic multiple myeloma growth in vitro and engraft immunodeficient nonobese diabetes/severe combined immunodeficient mice during both primary and secondary transplantation. Furthermore, both the side population and Aldefluor assays were capable of identifying circulating clonotypic memory B-cell populations within the peripheral blood of multiple myeloma patients. Our results suggest that circulating clonotypic B-cell populations represent multiple myeloma stem cells, and the relative drug resistance of these cells is mediated by processes that protect normal stem cells from toxic injury.},
 bibtype = {article},
 author = {Matsui, William and Wang, Qiuju and Barber, James P and Brennan, Sarah and Smith, B Douglas and Borrello, Ivan and McNiece, Ian and Lin, Lan and Ambinder, Richard F and Peacock, Craig and Watkins, D Neil and Huff, Carol Ann and Jones, Richard J},
 journal = {Cancer research},
 number = {1}
}

@Article{Elliot2007,
  author   = {Andrew J Elliot and Markus A Maier and Arlen C Moller and Ron Friedman and J\"org Meinhardt},
  journal  = {J Exp Psychol Gen},
  title    = {Color and psychological functioning: the effect of red on performance attainment.},
  year     = {2007},
  number   = {1},
  pages    = {154-68},
  volume   = {136},
  abstract = {This research focuses on the relation between color and psychological
	functioning, specifically, that between red and performance attainment.
	Red is hypothesized to impair performance on achievement tasks, because
	red is associated with the danger of failure in achievement contexts
	and evokes avoidance motivation. Four experiments demonstrate that
	the brief perception of red prior to an important test (e.g., an
	IQ test) impairs performance, and this effect appears to take place
	outside of participants' conscious awareness. Two further experiments
	establish the link between red and avoidance motivation as indicated
	by behavioral (i.e., task choice) and psychophysiological (i.e.,
	cortical activation) measures. The findings suggest that care must
	be taken in how red is used in achievement contexts and illustrate
	how color can act as a subtle environmental cue that has important
	influences on behavior.},
  doi      = {10.1037/0096-3445.136.1.154},
  keywords = {Achievement, Adolescent, Adult, Color Perception, Escape Reaction, Female, Humans, Male, Psychology, 17324089},
}

Website  abstract   bibtex   

@article{
 title = {No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Adult,Apolipoproteins E/*genetics,Cell Adhesion Molecules/*genetics,Disease Progression,Female,Gene Frequency,Genotype,Humans,Male,Middle Aged,Multiple Sclerosis/*genetics/physiopathology,Severity of Illness Index},
 pages = {156-160},
 volume = {186},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17376543},
 edition = {2007/03/23},
 id = {97823616-1f4d-37f6-a788-8ec55f360a74},
 created = {2017-06-19T13:43:25.441Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:25.558Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Ramagopalan, S V<m:linebreak/>Deluca, G C<m:linebreak/>Morrison, K M<m:linebreak/>Herrera, B M<m:linebreak/>Dyment, D A<m:linebreak/>Orton, S<m:linebreak/>Bihoreau, M T<m:linebreak/>Degenhardt, A<m:linebreak/>Pugliatti, M<m:linebreak/>Sadovnick, A D<m:linebreak/>Sotgiu, S<m:linebreak/>Ebers, G C<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>Netherlands<m:linebreak/>Journal of neuroimmunology<m:linebreak/>S0165-5728(07)00061-6<m:linebreak/>J Neuroimmunol. 2007 May;186(1-2):156-60. Epub 2007 Mar 21.</m:note>},
 abstract = {Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. Apolipoprotein E (APOE) is involved in neuronal remodelling and several studies have attempted to examine the effect of APOE on MS disease severity, but its function in modifying the course of MS is controversial. It has been suggested recently that PVRL2, not APOE, is the locus on chromosome 19 which influences clinical outcome of MS. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of APOE and PVRL2 on MS disease severity. The MS cases selected represent the prognostic best 5% (benign MS) and worst 5% (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that APOE or PVRL2 have any outcome modifying activity. We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS.},
 bibtype = {article},
 author = {Ramagopalan, S V and Deluca, G C and Morrison, K M and Herrera, B M and Dyment, D A and Orton, S and Bihoreau, M T and Degenhardt, A and Pugliatti, M and Sadovnick, A D and Sotgiu, S and Ebers, G C},
 journal = {J Neuroimmunol},
 number = {1-2}
}

@article{gentilini_is_2007,
	title = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours? {Lessons} from a series in a single institution},
	volume = {18},
	issn = {0923-7534},
	shorttitle = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours?},
	doi = {10.1093/annonc/mdm182},
	abstract = {BACKGROUND: Current guidelines for post-mastectomy radiotherapy (PMRT) derive largely from extrapolating information from multicentre trials. The aim of this study was to describe outcomes of patients who underwent mastectomy without radiotherapy in a single institution.
PATIENTS AND METHODS: 650 patients had total mastectomy and axillary dissection without PMRT between 1997 and 2001. Median follow-up was 65 months.
RESULTS: 5-year cumulative incidence of loco-regional recurrence (LRR) was 6.8\% (3.0, 8.1, 9.9\% in node negative, 1-3, {\textgreater} or =4 positive nodes, respectively). At the multivariate analysis, positive lymph nodes and endocrine non-responsive tumours were found to shorten LRR disease-free survival. In patients with positive hormone receptors, 5-year cumulative incidence of LRR disease-free survival were 2.3\%, 7.6\% and 7.6\% for node negative, 1-3 and {\textgreater} or =4 positive lymph nodes, respectively. The same figures were 5.9\%, 10.3\% and 20.0\% in patients with endocrine non-responsive tumours.
CONCLUSIONS: patients with endocrine-responsive tumours treated by mastectomy and complete (level III) axillary dissection have a low risk of LRR even if four or more positive lymph nodes are involved, thus giving rise to doubts on the use of PMRT in this subset of patients. On the other hand, PMRT might play a role for patients with negative hormone receptors and four or more positive nodes.},
	language = {eng},
	number = {8},
	journal = {Annals of oncology: official journal of the European Society for Medical Oncology / ESMO},
	author = {Gentilini, O and Botteri, E and Rotmensz, N and Intra, M and Gatti, G and Silva, L and Peradze, N and Sahium, R C and Gil, L B and Luini, A and Veronesi, P and Galimberti, V and Gandini, S and Goldhirsh, A and Veronesi, U},
	month = aug,
	year = {2007},
	pmid = {17693648},
	keywords = {Adult, Axilla, Breast Neoplasms, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Lymph Node Excision, mastectomy, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, Adjuvant, Retrospective Studies, Treatment Outcome},
	pages = {1342--1347},
	file = {Ann Oncol-2007-Gentilini-1342-7.pdf:files/46589/Ann Oncol-2007-Gentilini-1342-7.pdf:application/pdf}
}

Website  bibtex   

@article{
 title = {Point/Counterpoint. Proton therapy is the best radiation treatment modality for prostate cancer},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Clinical Trials as Topic/*trends,Humans,Male,Physician's Practice Patterns/*trends,Prostatic Neoplasms/*epidemiology/*radiotherapy,Protons/adverse effects/*therapeutic use,Radiation Injuries/etiology/prevention & control,Radiotherapy, Conformal/adverse effects/*methods,Risk Assessment},
 pages = {375-378},
 volume = {34},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17388153},
 edition = {2007/03/29},
 id = {b0987504-2aa6-3424-93bc-d7edc6cc3f82},
 created = {2017-06-19T13:43:25.395Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:25.490Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Moyers, Michael F<m:linebreak/>Pouliot, Jean<m:linebreak/>Orton, Colin G<m:linebreak/>United States<m:linebreak/>Medical physics<m:linebreak/>Med Phys. 2007 Feb;34(2):375-8.</m:note>},
 bibtype = {article},
 author = {Moyers, M F and Pouliot, J and Orton, C G},
 journal = {Med Phys},
 number = {2}
}

Paper  doi  bibtex   

@article{ gostin_mandatory_2007,
  title = {Mandatory {HPV} vaccination: public health vs private wealth},
  volume = {297},
  issn = {1538-3598},
  shorttitle = {Mandatory {HPV} vaccination},
  url = {http://www.progressiveconvergence.com/JAMA%20article.pdf},
  doi = {10.1001/jama.297.17.1921},
  language = {eng},
  number = {17},
  journal = {{JAMA}: the journal of the American Medical Association},
  author = {Gostin, Lawrence O and DeAngelis, Catherine D},
  month = {May},
  year = {2007},
  pmid = {17473303},
  keywords = {Female, Health Policy, Humans, Papillomavirus Vaccines, Policy Making, United States, Uterine Cervical Neoplasms, Vaccination},
  pages = {1921--1923}
}

@article{grizzle_reasons_2007,
	title = {Reasons provided by prescribers when overriding drug-drug interaction alerts},
	volume = {13},
	issn = {1936-2692},
	abstract = {OBJECTIVES: To investigate prescribers' rationales for overriding drug-drug interaction (DDI) alerts and to determine whether these reasons were helpful to pharmacists as a part of prescription order verification.
STUDY DESIGN: An observational retrospective database analysis was conducted using override reasons derived from a computerized system at 6 Veterans Affairs medical centers.
METHODS: Data on DDI alerts (for interactions designated as "critical" and "significant") were obtained from ambulatory care pharmacy records from July 1, 2003, to June 30, 2004. Prescribers' reasons for overriding alerts were organized into 14 categories and were then rated as clinically useful or not to the pharmacist in the assessment of potential patient harm.
RESULTS: Of 291,890 overrides identified, 72\% were for critical DDIs. Across the Veterans Affairs medical centers, only 20\% of the override reasons for critical DDI alerts were rated as clinically useful for order verification. Despite a mandatory override reason for critical DDI alerts, 53\% of the responses were "no reason provided." The top response categories for critical and significant DDI alerts were "no reason provided," "patient has been taking combination," and "patient being monitored."
CONCLUSIONS: When given the opportunity to provide a reason for overriding a DDI alert, prescribers rarely enter clinical justifications that are useful to order verification pharmacists. This brings into question how computerized physician order entry systems should be designed.},
	language = {eng},
	number = {10},
	journal = {The American journal of managed care},
	author = {Grizzle, Amy J and Mahmood, Maysaa H and Ko, Yu and Murphy, John E and Armstrong, Edward P and Skrepnek, Grant H and Jones, William N and Schepers, Gregory P and Nichol, W Paul and Houranieh, Antoun and Dare, Donna C and Hoey, Christopher T and Malone, Daniel C},
	month = oct,
	year = {2007},
	pmid = {17927462},
	keywords = {Adverse Drug Reaction Reporting Systems, Ambulatory Care Facilities, Attitude of Health Personnel, Drug Interactions, Drug Therapy, Computer-Assisted, Guideline Adherence, Hospitals, Veterans, Humans, Medical Order Entry Systems, Medication Errors, Observation, Pharmacy Service, Hospital, Physician's Practice Patterns, Retrospective Studies, United States},
	pages = {573--578}
}

@Article{Kovacs_2006_9144,
  author = {Kovacs, L. and Yassouridis, A. and Zimmermann, A. and Brockmann, G. and Wohnl, A. and Blaschke, M. and Eder, M. and Schwenzer-Zimmerer, K. and Rosenberg, R. and Papadopulos, N. A. and Biemer, E.},
 journal = {Annals of Plastic Surgery},
 number = {3},
 pages = {229-236},
 title = {Optimization of 3-dimensional imaging of the breast region with 3-dimensional laser scanners},
 volume = {56},
 year = {2006},
 keywords = {Breast/*anatomy, &, histology, Female, Humans, *Image, Processing, Computer-Assisted, Imaging, Three-Dimensional/*instrumentation, Lasers/diagnostic, use, Manikins, Phantoms, Imaging, Sensitivity, and, Specificity},
 title_with_no_special_chars = {Optimization of 3dimensional imaging of the breast region with 3dimensional laser scanners}
}

@article{fox_prevalence_2006,
	title = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database: {A} series of retrospective analyses of data from 1998 through 2002},
	volume = {28},
	issn = {0149-2918},
	shorttitle = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database},
	doi = {10.1016/j.clinthera.2006.03.005},
	abstract = {BACKGROUND: Since the mid-1990s, the development of new oral antidiabetic agents (OAs) and treatment guidelines have created an opportunity to improve glycemic control in patients with type 2 diabetes.
OBJECTIVES: This study aimed to assess the prevalence of good and inadequate glycemic control across a 5-year period among patients with diabetes in the United Kingdom. It also investigated the factors associated with achieving glycemic targets.
METHODS: This was a retrospective, cross-sectional analysis of data from the General Practice Research Database. Three limits were used to assess glycosylated hemoglobin (HbA1c): 6.5\%, 7.0\%, or 7.5\%. Values above the cutoffs indicated inadequate control of HbA1c; those at or below the cutoffs indicated good control. The study evaluated clinical and pharmacy data from the years 1998 to 2002 for patients with type 2 diabetes, {\textgreater} or =2 years of follow-up, and {\textgreater} or =2 HbA1c measurements during the first year. Five independent cross-sectional analyses were conducted, grouping data by year. Statistical significance was determined by Student t and chi2 tests.
RESULTS: Data were analyzed for 10,663 patients aged 17 to 98 years. The number of total eligible type 2 diabetes patients increased over the course of the study period: 5674 patients in 1998, 6553 in 1999, 7314 in 2000, 7323 in 2001, and 6192 in 2002. Overall, the study population had a mean (SD) age of 66 (11.0) years, was 53\% male (3033/5674), and had a body mass index of 29 kg/m(2). Seventy-six percent of patients had HbA1c {\textgreater}7.0\% and 37\% were taking {\textgreater} or =2 oral agents. In 1998 and 2002, 79\% (4482/5674) and 76\% (4732/6192) of patients, respectively, had inadequate glycemic control, defined as HbA1c {\textgreater}7.0\%. When defined as HbA1c {\textgreater}7.5\%, 69\% (3923/5674) and 62\% (3814/6192) of patients, respectively, had inadequate control. Finally, when defined as HbA1c {\textgreater}6.5\%, 88\% (5011/5674) of patients in both 1998 and 2002 had inadequate control. Compared with patients with good disease control (HbA1c {\textless} or =7.0\%), patients with inadequate control were approximately 2 years younger (P {\textless} 0.001) and had been prescribed more OAs: 41\% received {\textgreater} or =2 OAs in 1998 and 52\% in 2002, compared with 23\% and 34\% (both, P = 0.001), respectively, of patients with good glycemic control (P {\textless} 0.02). Sex, number of diabetes complications, and number of comorbidities did not differ between groups (P = NS).
CONCLUSIONS: Despite the introduction of new OAs and treatment guidelines, the prevalence of inadequate glycemic control remains high ({\textgreater}60\%) in patients with type 2 diabetes in the United Kingdom. Regardless of the HbA1c cutoff, patients with inadequate control were younger and received prescriptions for more OAs than patients with good control.},
	language = {eng},
	number = {3},
	journal = {Clinical Therapeutics},
	author = {Fox, Kathleen M. and Gerber Pharmd, Robert A. and Bolinder, Bjorn and Chen, Jack and Kumar, Sanjaya},
	month = mar,
	year = {2006},
	pmid = {16750453},
	keywords = {Administration, Oral, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Family Practice, Female, Great Britain, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Retrospective Studies, databases as topic},
	pages = {388--395}
}

@article{ hommet_idiopathic_2006,
  title = {Idiopathic epileptic syndromes and cognition},
  volume = {30},
  issn = {0149-7634},
  doi = {10.1016/j.neubiorev.2005.06.004},
  abstract = {Epilepsy is frequently associated with cognitive impairments which result from various interacting factors. The present paper deals with the contribution of neuropsychology to the characterization of the type of epilepsy and the possible mechanisms underlying idiopathic epileptic syndromes. The non-lesional, so-called idiopathic epilepsies, constitute an interesting model for assessing the relationship between epileptiform {EEG} discharges and cognition. Among the idiopathic generalized epilepsies, disorders of social integration and personality have been frequently reported in juvenile myoclonic epilepsy ({JME}). Since similar disturbances are observed in frontal-lobe-lesioned patients, impairments in other frontal lobe functions (e.g. executive functions) might be expected in {JME}. This gives rise to speculation about the possible underlying pathophysiological mechanisms in {JME}. With regard to partial idiopathic epilepsies, benign childhood epilepsy with centrotemporal spikes ({BCECTS}) may provide a useful model for the study of the relationship between epileptiform {EEG} discharges in the peri-sylvian region and language functions. Furthermore, the description of mild cognitive dysfunctions in {BCECTS}, and their persistence into adulthood, can provide information about compensatory mechanisms and may allow for the generation of remedial strategies. Thus, 'lesional' neuropsychology has given way to 'dynamic' neuropsychology based on specific postulates. By using the cognitive profile to specify the mechanism underlying the behavioral disturbances observed in different types of epilepsy, neuropsychology may eventually contribute to a revision of the present classification of epileptic syndromes. In addition, the neuropsychological data may help predict the extent and limits of functional recovery and cerebral plasticity.},
  language = {eng},
  number = {1},
  journal = {Neuroscience and Biobehavioral Reviews},
  author = {Hommet, Caroline and Sauerwein, Hannelore C. and De Toffol, Bertrand and Lassonde, Maryse},
  year = {2006},
  pmid = {16120462},
  keywords = {Cognition Disorders, Electroencephalography, Epilepsy, Humans, Neuropsychology, Syndrome},
  pages = {85--96}
}

Paper  bibtex   

@article{
 id = {d14cb890-55c2-3ae7-867b-c26ce0888855},
 title = {Deadspace: invasive or not?},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Breath Tests,Breath Tests: methods,Capnography,Carbon Dioxide,Carbon Dioxide: analysis,Humans,Respiratory Dead Space,Respiratory Distress Syndrome, Adult,Respiratory Distress Syndrome, Adult: physiopathol},
 created = {2009-07-23T22:42:16.000Z},
 pages = {4-7},
 volume = {96},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16357115},
 month = {1},
 file_attached = {true},
 profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
 group_id = {f87494e7-529d-3e68-b1f1-0e6d57d138db},
 last_modified = {2014-07-19T19:15:28.000Z},
 read = {false},
 starred = {true},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Drummond2006},
 client_data = {"desktop_id":"3003a2ac-bf9a-4502-9b9f-c80e15e72d57"},
 bibtype = {article},
 author = {Drummond, G B and Fletcher, R},
 journal = {British journal of anaesthesia},
 number = {1}
}

@article{shepherd_comparison_2006,
	title = {Comparison of {BMD} precision for {Prodigy} and {Delphi} spine and femur scans},
	volume = {17},
	issn = {0937-941X},
	doi = {10.1007/s00198-006-0127-9},
	abstract = {INTRODUCTION: Precision error in bone mineral density (BMD) measurement can be affected by patient positioning, variations in scan analysis, automation of software, and both short- and long-term fluctuations of the densitometry equipment. Minimization and characterization of these errors is essential for reliable assessment of BMD change over time.
METHODS: We compared the short-term precision error of two dual-energy X-ray absorptiometry (DXA) devices: the Lunar Prodigy (GE Healthcare) and the Delphi (Hologic). Both are fan-beam DXA devices predominantly used to measure BMD of the spine and proximal femur. In this study, 87 women (mean age 61.6+/-8.9 years) were measured in duplicate, with repositioning, on both systems, at one of three clinical centers. The technologists were International Society for Clinical Densitometry (ISCD) certified and followed manufacturer-recommended procedures. All scans were acquired using 30-s scan modes. Precision error was calculated as the root-mean-square standard deviation (RMS-SD) and coefficient of variation (RMS-\%CV) for the repeated measurements. Right and left femora were evaluated individually and as a combined dual femur precision. Precision error of Prodigy and Delphi measurements at each measurement region was compared using an F test to determine significance of any observed differences.
RESULTS: While precision errors for both systems were low, Prodigy precision errors were significantly lower than Delphi at L1-L4 spine (1.0\% vs 1.2\%), total femur (0.9\% vs 1.3\%), femoral neck (1.5\% vs 1.9\%), and dual total femur (0.6\% vs 0.9\%). Dual femur modes decreased precision errors by approximately 25\% compared with single femur results.
CONCLUSIONS: This study suggests that short-term BMD precision errors are skeletal-site and manufacturer specific. In clinical practice, precision should be considered when determining: (a) the minimum time interval between baseline and follow-up scans and (b) whether a statistically significant change in the patient's BMD has occurred.},
	language = {eng},
	number = {9},
	journal = {Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA},
	author = {Shepherd, J. A. and Fan, B. and Lu, Y. and Lewiecki, E. M. and Miller, P. and Genant, H. K.},
	year = {2006},
	pmid = {16823544},
	keywords = {Absorptiometry, Photon, Aged, Aged, 80 and over, Bone Density, Female, Femur, Femur Neck, Hip Joint, Humans, Lumbar Vertebrae, Middle Aged, Osteoporosis, Postmenopausal, Postmenopause, Reproducibility of Results},
	pages = {1303--1308}
}

@article{westhoff_tacrolimus_2006,
	title = {Tacrolimus in steroid-resistant and steroid-dependent nephrotic syndrome.},
	volume = {65},
	issn = {0301-0430 0301-0430},
	abstract = {BACKGROUND: Steroid resistance and steroid dependence constitute a major problem  in the treatment of minimal-change disease and focal segmental glomerulosclerosis (FSGS). Cyclophosphamide and cyclosporine are well-established alternative immunomodulating agents, whereas data on FK 506 (tacrolimus) are rare. METHODS: The present work provides data from 10 patients of an open, monocentric, non-randomized, prospective trial. Five patients with steroid-dependent minimal-change nephrotic syndrome, 1 patient with steroid-refractory minimal-change disease and 4 patients with steroid-refractory FSGS were started on tacrolimus at trough levels of 5 10 microg/l. In case of steroid-dependence, prednisolone was tapered off in presence oftacrolimus within one month. RESULTS:  Within 6 months, complete remission was achieved in 5 patients (50\%) and partial  remission in 4 patients (40\%), yielding a final response rate of 90\%. One patient was primarily resistent to tacrolimus (steroid-refractory minimal-change), another patient became secondarily resistant to tacrolimus after an initial remission (steroid-refractory FSGS). Average proteinuria significantly decreased  by 77\% from 9.5 +/- 1.4 - 2.2 +/- 1.1 g/day (p {\textless} 0.01). Serum protein significantly raised from 55.0 +/- 1.9 - 64.6 +/- 1.9 g/l (p {\textless} 0.01). Tacrolimus  induced non-significant increases of blood glucose (4.9 +/- 0.1 - 5.1 +/- 0.2 mmol/l), systolic blood pressure (131.4 +/- 7.1 - 139.0 +/- 7.6 mmHg) and creatinine (93.2 +/- 13.9 103.2 +/- 15.3 mmol/l). Five patients have been tapered off tacrolimus so far, nephrotic syndrome relapsed in 4 of them (80\%). Relapse occurred at tacrolimus levels between 2.6 and 6.9 ng/ml. CONCLUSIONS: Our data suggest that tacrolimus may be a promising alternative to cyclosporine both in steroid-resistant and steroid-dependent nephrotic syndrome.},
	language = {eng},
	number = {6},
	journal = {Clinical nephrology},
	author = {Westhoff, T. H. and Schmidt, S. and Zidek, W. and Beige, J. and van der Giet, M.},
	month = jun,
	year = {2006},
	pmid = {16792133},
	keywords = {Adult, Blood Glucose/analysis, Blood Pressure/drug effects, Blood Proteins/analysis, Creatinine/urine, Drug Resistance, Drug Therapy, Combination, Female, Glomerulosclerosis, Focal Segmental/drug therapy, Humans, Male, Middle Aged, Nephrosis, Lipoid/drug therapy, Nephrotic Syndrome/*drug therapy, Prednisolone/therapeutic use, Proteinuria/drug therapy, Steroids/pharmacology/*therapeutic use, Tacrolimus/*therapeutic use},
	pages = {393--400}
}

@article{hippisley-cox_qflu:_2006,
	title = {{QFLU}: new influenza monitoring in {UK} primary care to support pandemic influenza planning},
	volume = {11},
	issn = {1560-7917},
	shorttitle = {{QFLU}},
	language = {eng},
	number = {6},
	journal = {Euro Surveillance: Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin},
	author = {Hippisley-Cox, J. and Smith, S. and Smith, G. and Porter, A. and Heaps, M. and Holland, R. and Fenty, J. and Harcourt, S. and George, R. and Charlett, A. and Pebody, R. G. and Painter, M.},
	year = {2006},
	pmid = {16819130},
	keywords = {Communicable Disease Control, Disease Notification, Disease Outbreaks, Family Practice, Great Britain, Health Planning, Humans, Influenza, Human, Population Surveillance, Primary Health Care, Risk Assessment, Risk Factors, incidence},
	pages = {E060622.4}
}

@article{werbrouck_no_2006,
	title = {No difference in cycle pregnancy rate and in cumulative live-birth rate between women with surgically treated minimal to mild endometriosis and women with unexplained infertility after controlled ovarian hyperstimulation and intrauterine insemination},
	volume = {86},
	issn = {1556-5653},
	doi = {10.1016/j.fertnstert.2006.01.044},
	abstract = {OBJECTIVE: The association between infertility and minimal to mild endometriosis is controversial and poorly understood. The clinical pregnancy rate (PR) per cycle after controlled ovarian hyperstimulation (COH) with or without intrauterine insemination (IUI) is reportedly lower in women with surgically untreated minimal to mild endometriosis than in women with unexplained infertility. It is possible that prior laparoscopic removal of endometriosis has a positive effect on the clinical PR after COH and IUI. Therefore, we tested the hypothesis that after COH and IUI the PR per cycle and the cumulative live-birth rate (CLBR) are equal or higher in women with recently surgically treated minimal to mild endometriosis when compared with women with unexplained infertility.
DESIGN: A retrospective, controlled cohort study.
SETTING: Leuven University Fertility Centre, a tertiary academic referral center.
PATIENT(S): One hundred seven women treated during 259 cycles with COH and IUI including patients with endometriosis (n = 58, 137 cycles) and unexplained infertility (n = 49, 122 cycles). All patients with endometriosis had minimal (n = 41, 100 cycles) or mild (n = 17, 37 cycles) disease that had been laparoscopically removed within 7 months before the onset of treatment with COH and IUI.
INTERVENTION(S): Controlled ovarian hyperstimulation using clomiphene citrate (23 cycles) or gonadotrophins (236 cycles) in combination with IUI.
MAIN OUTCOME MEASURE(S): Clinical PR per cycle and CLBR within four cycles of treatment with COH and IUI.
RESULT(S): The clinical PR per cycle was comparable in women with minimal or mild endometriosis (21\% or 18.9\%, respectively) and in women with unexplained infertility (20.5\%). The CLBR within four cycles of COH and IUI was also comparable in women with minimal endometriosis, mild endometriosis, and unexplained infertility (70.2\%, 68.2 \%, 66.5\%, respectively).
CONCLUSION(S): The data from our study suggest that COH and IUI shortly after laparoscopic excision of endometriosis is as effective as COH and IUI in patients with unexplained subfertility.},
	language = {eng},
	number = {3},
	journal = {Fertility and Sterility},
	author = {Werbrouck, Erika and Spiessens, Carl and Meuleman, Christel and D'Hooghe, Thomas},
	month = sep,
	year = {2006},
	pmid = {16952506},
	keywords = {Adult, Comorbidity, Endometriosis, Female, Humans, Infertility, Insemination, Artificial, Laparoscopy, Live Birth, Menstrual Cycle, Ovulation Induction, Pregnancy, Pregnancy Rate, Prevalence, Prognosis, Retrospective Studies, Treatment Outcome},
	pages = {566--571}
}

@Article{Rasouli_2006_906,
  author = {Rasouli, M.L. and Shavelle, D.M. and French, W.J. and McKay, C.R. and Budoff, M.J.},
 journal = {Coronary Artery Dispatch},
 note = {0954-6928 (Print) Clinical Trial Comparative Study Journal Article Research Support, Non-U.S. Gov't},
 number = {4},
 pages = {359-364},
 title = {Assessment of coronary plaque morphology by contrast-enhanced computed tomographic angiography: {C}omparison with intravascular ultrasound},
 volume = {17},
 year = {2006},
 keywords = {Contrast, Media, Coronary, Angiography/*methods, Coronary, Arteriosclerosis/*radiography/*ultrasonography, Coronary, Vessels/pathology/ultrasonography, Female, Humans, Image, Processing, Computer-Assisted, Male, Middle, Aged, Tomography, X-Ray, Computed/*methods, Ultrasonography, Interventional/*methods},
 title_with_no_special_chars = {Assessment of coronary plaque morphology by contrastenhanced computed tomographic angiography Comparison with intravascular ultrasound}
}

Website  abstract   bibtex   

@article{
 title = {The knowledge-value chain: A conceptual framework for knowledge translation in health},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Biomedical Research,Humans,Information Dissemination,Information Systems,Public Health Administration,conceptual framework,education policy,evidence based medicine,health care organization,health care policy,health practitioner,health program,health service,human,human relation,knowledge,learning,medical literature,medical practice,medical research,professional knowledge,public health,review,systematic review,world health organization},
 pages = {597-602},
 volume = {84},
 websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33748346673&partnerID=40&md5=07c2c903c1ddffd98d455121833cb07e},
 city = {Affiliation: Department of Management, Faculty of Business, Laval University, Québec City, Que. G1K 7P4, Canada; Affiliation: Department of Knowledge Management and Sharing, World Health Organization, 1211 Geneva 27, Switzerland; Affiliation: Canadian Hea},
 id = {db3b79d4-cc6a-393c-b38b-1e9fdae127d4},
 created = {2016-08-21T22:17:40.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {Cited By (since 1996): 34},
 folder_uuids = {028056a6-dab5-46a4-b9bf-02542e7cfa2b},
 private_publication = {false},
 abstract = {This article briefly discusses knowledge translation and lists the problems associated with it. Then it uses knowledge-management literature to develop and propose a knowledge-value chain framework in order to provide an integrated conceptual model of knowledge management and application in public health organizations. The knowledge-value chain is a non-linear concept and is based on the management of five dyadic capabilities: mapping and acquisition, creation and destruction, integration and sharing/transfer, replication and protection, and performance and innovation.},
 bibtype = {article},
 author = {Landry, R and Amara, N and Pablos-Mendes, A and Shademani, R and Gold, I},
 journal = {Bulletin of the World Health Organization},
 number = {8}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Biological evidence for inheritance of exceptional longevity},
 type = {article},
 year = {2005},
 identifiers = {[object Object]},
 keywords = {Age Factors,Aged,Aged, 80 and over,Aging/*ethnology/*genetics,Alleles,Carrier Proteins/genetics,Case-Control Studies,Genotype,Glycoproteins/genetics,Homozygote,Humans,Lipids/metabolism,Lipoproteins, HDL/genetics/metabolism,Lipoproteins, LDL/genetics/metabolism,Longevity/*genetics,Phenotype,Polymorphism, Genetic,Valine/genetics},
 pages = {341-345},
 volume = {126},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15621216},
 id = {ac53ce7e-fc6c-35da-8438-be74b645fce9},
 created = {2017-06-19T13:45:30.857Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:45:31.024Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0047-6374<m:linebreak/>Journal Article</m:note>},
 abstract = {Subjects with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility. In a case control study, we aim to determine phenotype and genotype of exceptional longevity in a genetically homogenous population (Ashkenazi Jews), and their offspring, while an age-matched control group of Ashkenazi Jews was used as control groups. We demonstrated that exceptional longevity and healthy aging in humans is an inherited phenotype across three generations. Moreover, we demonstrated that subjects with exceptional longevity and their offspring have significantly larger high-density lipoprotein (HDL) levels and particle sizes and low-density lipoprotein (LDL) levels that reflect on their health and cognitive function performance. This phenotype have led us to study candidate genes involved in lipoprotein metabolism, and to the implication of homozygosity for the 405 valine (V) allele of cholesteryl ester transfer protein (CETP). A markedly higher frequency of a functional CETP variant that led to increased particle sizes of HDL and LDL and thus a better health performance is the first example of a phenotype and an associated genotype in humans with exceptional longevity. Hopefully, this line of research will lead us to establish which genotype is necessary (although not necessary sufficient) for a prolonged disease-free aging.},
 bibtype = {article},
 author = {Atzmon, G and Rincon, M and Rabizadeh, P and Barzilai, N},
 journal = {Mech Ageing Dev},
 number = {2}
}

Paper  abstract   bibtex   

@article{
 title = {Modelling the recent common ancestry of all living humans},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {*Computer Simulation,*Pedigree,*Phylogeny,Emigration and Immigration,Female,Geography,Humans,Male,Monte Carlo Method,Population Density,Population Dynamics,Reproduction,Research Support, U.S. Gov't, P.H.S.,Time Factors},
 pages = {562-566},
 volume = {431},
 id = {c213cb6e-eeef-3a9b-8149-72c0b09cf516},
 created = {2017-06-19T13:43:49.961Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:50.083Z},
 tags = {04/12/23},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>Journal Article</m:note>},
 abstract = {If a common ancestor of all living humans is defined as an individual who is a genealogical ancestor of all present-day people, the most recent common ancestor (MRCA) for a randomly mating population would have lived in the very recent past. However, the random mating model ignores essential aspects of population substructure, such as the tendency of individuals to choose mates from the same social group, and the relative isolation of geographically separated groups. Here we show that recent common ancestors also emerge from two models incorporating substantial population substructure. One model, designed for simplicity and theoretical insight, yields explicit mathematical results through a probabilistic analysis. A more elaborate second model, designed to capture historical population dynamics in a more realistic way, is analysed computationally through Monte Carlo simulations. These analyses suggest that the genealogies of all living humans overlap in remarkable ways in the recent past. In particular, the MRCA of all present-day humans lived just a few thousand years ago in these models. Moreover, among all individuals living more than just a few thousand years earlier than the MRCA, each present-day human has exactly the same set of genealogical ancestors.},
 bibtype = {article},
 author = {Rohde, D L and Olson, S and Chang, J T},
 journal = {Nature},
 number = {7008}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Founder mutations among the Dutch},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {*Founder Effect,Alleles,European Continental Ancestry Group/*genetics/hist,Female,Gene Frequency/genetics,Genetic Diseases, Inborn/*genetics,Genetics, Population,History, 15th Century,History, 16th Century,History, 17th Century,History, 18th Century,History, 19th Century,History, 20th Century,History, 21st Century,History, Ancient,History, Medieval,Humans,Male,Mutation/*genetics,Netherlands,Pedigree},
 pages = {591-600},
 volume = {12},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15010701},
 id = {861dba44-a72a-37ad-a54b-b4f70aed149d},
 created = {2017-06-19T13:46:04.892Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:46:05.028Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1018-4813 (Print)<m:linebreak/>Historical Article<m:linebreak/>Journal Article<m:linebreak/>Review</m:note>},
 abstract = {Many genetic disorders demonstrate mutations that can be traced to a founder, sometimes a person who can be identified. These founder mutations have generated considerable interest, because they facilitate studies of prevalence and penetrance and can be used to quantify the degree of homogeneity within a population. This paper reports on founder mutations among the Dutch and relates their occurrence to the history and demography of the Netherlands. International migration, regional and religious endogamy, and rapid population growth played key roles in shaping the Dutch population. In the first millenniums BC and AD, the Netherlands were invaded by Celts, Romans, Huns, and Germans. In more recent times, large numbers of Huguenots and Germans migrated into the Netherlands. Population growth within the Netherlands was slow until the 19th century, when a period of rapid population growth started. Today, the Dutch population numbers 16 million inhabitants. Several different classes of founder mutations have been identified among the Dutch. Some mutations occur among people who represent genetic isolates within this country. These include mutations for benign familial cholestasis, diabetes mellitus, type I, infantile neuronal ceroid lipofuscinosis, L-DOPA responsive dystonia, and triphalangeal thumb. Although not related to a specific isolate, other founder mutations were identified only within the Netherlands, including those predisposing for hereditary breast-ovarian cancer, familial hypercholesterolemia, frontotemporal dementia, hereditary paragangliomas, juvenile neuronal ceroid lipofuscinosis, malignant melanoma, protein C deficiency, and San Filippo disease. Many of these show a regional distribution, suggesting dissemination from a founder. Some mutations that occur among the Dutch are shared with other European populations and others have been transmitted by Dutch emigres to their descendents in North America and South Africa. The occurrence of short chromosomal regions that have remained identical by descent has resulted in relatively limited genetic heterogeneity for many genetic conditions among the Dutch. These observations demonstrate the opportunity for gene discovery for other diseases and traits in the Netherlands.},
 bibtype = {article},
 author = {Zeegers, M P and van Poppel, F and Vlietinck, R and Spruijt, L and Ostrer, H},
 journal = {Eur J Hum Genet},
 number = {7}
}

Paper  doi  abstract   bibtex   

@article{chen_over_2004,
	title = {Over 20\% of human transcripts might form sense-antisense pairs.},
	volume = {32},
	issn = {1362-4962},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=519112&tool=pmcentrez&rendertype=abstract},
	doi = {10.1093/nar/gkh818},
	abstract = {The major challenge to identifying natural sense- antisense (SA) transcripts from public databases is how to determine the correct orientation for an expressed sequence, especially an expressed sequence tag sequence. In this study, we established a set of very stringent criteria to identify the correct orientation of each human transcript. We used these orientation-reliable transcripts to create 26 741 transcription clusters in the human genome. Our analysis shows that 22\% (5880) of the human transcription clusters form SA pairs, higher than any previous estimates. Our orientation-specific RT-PCR results along with the comparison of experimental data from previous studies confirm that our SA data set is reliable. This study not only demonstrates that our criteria for the prediction of SA transcripts are efficient, but also provides additional convincing data to support the view that antisense transcription is quite pervasive in the human genome. In-depth analyses show that SA transcripts have some significant differences compared with other types of transcripts, with regard to chromosomal distribution and Gene Ontology-annotated categories of physiological roles, functions and spatial localizations of gene products.},
	number = {16},
	journal = {Nucleic acids research},
	author = {Chen, Jianjun and Sun, Miao and Kent, W James and Huang, Xiaoqiu and Xie, Hanqing and Wang, Wenquan and Zhou, Guolin and Shi, Run Zhang and Rowley, Janet D},
	month = jan,
	year = {2004},
	pmid = {15356298},
	keywords = {Antisense, Antisense: analysis, Antisense: chemistry, Antisense: genetics, Base Pairing, Chromosomes, Genetic, Genome, Human, Humans, Messenger, Messenger: chemistry, RNA, Reverse Transcriptase Polymerase Chain Reaction, Transcription},
	pages = {4812--20}
}

Paper  abstract   bibtex   

@article{
 title = {A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor.},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {Adult,Chromosomes, Human, Pair 22,Ependymoma,Ependymoma: diagnosis,Ependymoma: genetics,Female,Genes, Neurofibromatosis 2,Germ-Line Mutation,Humans,Loss of Heterozygosity,Male,Microsatellite Repeats,Pedigree,Spinal Neoplasms,Spinal Neoplasms: genetics},
 pages = {598-602},
 volume = {48},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/14566482},
 month = {1},
 id = {27bbabe4-815b-349a-bf02-494ff0fc34a0},
 created = {2014-08-02T22:29:07.000Z},
 accessed = {2014-08-02},
 file_attached = {true},
 profile_id = {be299c88-7105-3a8d-a1cd-3aa95c25e2c4},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T21:45:19.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Familial ependymal tumors are a very rare disease, the pathogenesis of which is unknown. Previous studies indicate an involvement of tumor suppressor genes localized within chromosomal region 22q, whereas details are still unclear. Here we report a non-neurofibromatosis type-2 (non-NF2) Japanese family in which two of the four members are affected with cervical spinal cord ependymoma, and one of the four is affected with schwannoma. Loss of heterozygosity (LOH) studies were carried out searching for common allelic loss at chromosomal region 22q11.2-qtel in two of the affected patients. Our findings support a prediction for existence of a tumor suppressor gene on chromosome 22 especially related to the tumorigenesis of familial ependymal tumors.},
 bibtype = {article},
 author = {Yokota, Takashi and Tachizawa, Takayuki and Fukino, Koichi and Teramoto, Akira and Kouno, Jun and Matsumoto, Koshi and Emi, Mitsuru},
 journal = {Journal of human genetics},
 number = {11}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Eye-movements aid the control of locomotion.},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {Automobile Driving,Eye Movements,Eye Movements: physiology,Fixation,Humans,Locomotion,Locomotion: physiology,Movement,Movement: physiology,Ocular,Ocular: physiology,Psychomotor Performance,Psychomotor Performance: physiology,Visual Perception,Visual Perception: physiology},
 pages = {677-84},
 volume = {3},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/14765952},
 id = {fb609291-5441-3bae-884d-450939ffbfd8},
 created = {2016-01-12T14:39:08.000Z},
 file_attached = {true},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Eye-movements have long been considered a problem when trying to understand the visual control of locomotion. They transform the retinal image from a simple expanding pattern of moving texture elements (pure optic flow), into a complex combination of translation and rotation components (retinal flow). In this article we investigate whether there are measurable advantages to having an active free gaze, over a static gaze or tracking gaze, when steering along a winding path. We also examine patterns of free gaze behavior to determine preferred gaze strategies during active locomotion. Participants were asked to steer along a computer-simulated textured roadway with free gaze, fixed gaze, or gaze tracking the center of the roadway. Deviation of position from the center of the road was recorded along with their point of gaze. It was found that visually tracking the middle of the road produced smaller steering errors than for fixed gaze. Participants performed best at the steering task when allowed to sample naturally from the road ahead with free gaze. There was some variation in the gaze strategies used, but sampling was predominantly of areas proximal to the center of the road. These results diverge from traditional models of flow analysis.},
 bibtype = {article},
 author = {Wilkie, R. M. and Wann, J. P.},
 journal = {Journal of vision},
 number = {11}
}

@Article{Ridker_2002_1393,
  author = {Ridker, P.M. and Rifai, N. and Rose, L. and Buring, J.E. and Cook, N.R.},
 journal = {New England Journal of Medicine},
 note = {Hl-43851/hl/nhlbi Hl-58755/hl/nhlbi Hl-63293/hl/nhlbi Comparative Study Evaluation Studies Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States},
 number = {20},
 pages = {1557-1565},
 title = {Comparison of {C}-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events},
 volume = {347},
 year = {2002},
 keywords = {Aged, Biological, Markers/blood, C-Reactive, Protein/*analysis, Cardiovascular, Diseases/blood/*epidemiology, Cholesterol, LDL/*blood, Disease-Free, Survival, Female, Hormone, Replacement, Therapy, Humans, Incidence, Longitudinal, Studies, Middle, Aged, Multivariate, Analysis, Prognosis, ROC, Curve, Risk, Risk, Factors},
 title_with_no_special_chars = {Comparison of Creactive protein and lowdensity lipoprotein cholesterol levels in the prediction of first cardiovascular events}
}

@article{schlienger_use_2002,
	title = {Use of nonsteroidal anti-inflammatory drugs and the risk of first-time acute myocardial infarction},
	volume = {54},
	issn = {0306-5251},
	abstract = {AIMS: Aspirin decreases the risk of clinical manifestations of atherothrombosis. This effect is mainly due to inhibition of platelet aggregation and potentially due to anti-inflammatory properties of aspirin. To evaluate whether use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) may also be associated with a decreased risk of first-time acute myocardial infarction (AMI), we performed a population-based case-control analysis using the United Kingdom-based General Practice Research Database (GPRD) METHODS: We identified first-time AMI-patients free of preexisting diagnosed cardiovascular or metabolic diseases. We compared use of NSAIDs prior to the index date between cases and control patients who were matched to cases on age, gender, practice and calendar time.
RESULTS: A total of 3319 cases ({\textless}or=75 years) with a diagnosis of first-time AMI between 1992 and 1997 and 13139 controls (matched to cases on age, sex, general practice attended, calendar time, years of prior history in the GPRD) were included. Overall, the relative risk estimate of AMI (adjusted for smoking, body mass index, hormone replacement therapy and aspirin) in current NSAID users was 1.17 (95\% CI 0.99, 1.37). Long-term current NSAID use ({\textgreater}or=30 prescriptions) yielded an adjusted odds ratio (OR) of 1.20 (95\% CI 0.94, 1.55). Stratification by age ({\textless}65 years vs{\textgreater}or=65 years) and sex did not materially change the results.
CONCLUSIONS: Our findings indicate that current NSAID exposure in patients free of diagnosed cardiovascular or metabolic conditions predisposing to cardiovascular diseases does not decrease the risk of AMI.},
	language = {eng},
	number = {3},
	journal = {British Journal of Clinical Pharmacology},
	author = {Schlienger, Raymond G. and Jick, Hershel and Meier, Christoph R.},
	month = sep,
	year = {2002},
	pmid = {12236854},
	pmcid = {PMC1874430},
	keywords = {Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Female, Great Britain, Humans, Male, Middle Aged, Myocardial Infarction, Risk Assessment, Risk Factors},
	pages = {327--332}
}

@Article{Fayad_2002_1428,
  author = {Fayad, Z. A.},
 journal = {Neuroimaging Clin.N.Am.},
 note = {DA - 20021218 NOT IN FILE},
 number = {3},
 pages = {461-471},
 title = {Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI},
 volume = {12},
 year = {2002},
 keywords = {Animals, Arteries, Arteriosclerosis, Atherosclerosis, Contrast, Media, Coronary, Arteriosclerosis, Coronary, Vessels, diagnosis, Disease, Progression, Humans, Magnetic, Resonance, Angiography, Magnetic, Resonance, Imaging, methods, pathology, Research, Support, Non-U.S.Gov't, Research, Support, U.S.Gov't, P.H.S., Rupture, therapy},
 title_with_no_special_chars = {Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI}
}

@Article{Higuchi_2002_1340,
  author = {Higuchi, M. L. and Gutierrez, P. S. and Bezerra, H. G. and Palomino, S. A. and Aiello, V. D. and Silvestre, J. M. and Libby, P. and Ramires, J. A.},
 journal = {Arq Bras.Cardiol.},
 note = {DA - 20020806 NOT IN FILE},
 number = {1},
 pages = {20-24},
 title = {Comparison between adventitial and intimal inflammation of ruptured and nonruptured atherosclerotic plaques in human coronary arteries},
 volume = {79},
 year = {2002},
 keywords = {Aneurysm, Arteries, Arteritis, Cadaver, Coronary, Arteriosclerosis, Coronary, Vessels, Endothelium, Vascular, Fibrosis, Humans, Inflammation, Lymphocyte, Count, Lymphocytes, methods, Myocardial, Infarction, pathology, Research, Support, Non-U.S.Gov't, Rupture},
 title_with_no_special_chars = {Comparison between adventitial and intimal inflammation of ruptured and nonruptured atherosclerotic plaques in human coronary arteries}
}

@article{kawasaki_dexterous_2002,
	title = {Dexterous anthropomorphic robot hand with distributed tactile sensor: {Gifu} hand {II}},
	volume = {7},
	issn = {1083-4435},
	shorttitle = {Dexterous anthropomorphic robot hand with distributed tactile sensor},
	doi = {10.1109/TMECH.2002.802720},
	abstract = {This paper presents an anthropomorphic robot hand, called the Gifu hand II, which has a thumb and four fingers, all the joints of which are driven by servomotors built into the fingers and the palm. The thumb has four joints with four-degrees-of-freedom (DOF), the other fingers have four joints with 3-DOF, and two axes of the joints near the palm cross orthogonally at one point, as is the case in the human hand. The Gifu hand II can be equipped with six-axes force sensor at each fingertip, and a developed distributed tactile sensor with 624 detecting points on its surface. The design concepts and specifications of the Gifu hand II, the basic characteristics of the tactile sensor, and the pressure distributions at the time of object grasping are described and discussed herein. Our results demonstrate that the Gifu hand II has a high potential to perform dexterous object manipulations like the human hand.},
	number = {3},
	journal = {IEEE/ASME Transactions on Mechatronics},
	author = {Kawasaki, H. and Komatsu, T. and Uchiyama, K.},
	month = sep,
	year = {2002},
	keywords = {Anthropomorphism, Cables, Fingers, Gifu Hand II, Humanoid robots, Humans, Orbital robotics, Robot sensing systems, Systems engineering and theory, Tendons, anthropomorphic robot hand, dexterous manipulators, dexterous robot hand, distributed tactile sensor, force sensor, humanoid, manipulator kinematics, multifinger hand, object grasping, pressure distributions, servomotors, tactile sensors},
	pages = {296--303}
}

@article{Weber2002,
  title = {Building an Asynchronous Web-Based Tool for Machine Learning Classification.},
  author = {Weber, Griffin and Vinterbo, Staal and {Ohno-Machado}, Lucila},
  year = {2002},
  journal = {JAMIA},
  volume = {Suppl. S},
  pages = {869--73},
  abstract = {Various unsupervised and supervised learning methods including support vector machines, classification trees, linear discriminant analysis and nearest neighbor classifiers have been used to classify high-throughput gene expression data. Simpler and more widely accepted statistical tools have not yet been used for this purpose, hence proper comparisons between classification methods have not been conducted. We developed free software that implements logistic regression with stepwise variable selection as a quick and simple method for initial exploration of important genetic markers in disease classification. To implement the algorithm and allow our collaborators in remote locations to evaluate and compare its results against those of other methods, we developed a user-friendly asynchronous web-based application with a minimal amount of programming using free, downloadable software tools. With this program, we show that classification using logistic regression can perform as well as other more sophisticated algorithms, and it has the advantages of being easy to interpret and reproduce. By making the tool freely and easily available, we hope to promote the comparison of classification methods. In addition, we believe our web application can be used as a model for other bioinformatics laboratories that need to develop web-based analysis tools in a short amount of time and on a limited budget.},
  copyright = {All rights reserved},
  pii = {D020001919},
  pubmedid = {12463949},
  keywords = {12463949,Algorithms,Anonymous Testing,Artificial Intelligence,Carcinoma,Child,Comparative Study,Computerized,Confidentiality,Databases,Diagnosis,Differential,Disclosure,DNA,Gene Expression,Gene Expression Profiling,Gene Expression Regulation,Genetic Markers,Humans,Internet,Logistic Models,Lung Neoplasms,Medical Records Systems,Multivariate Analysis,Neoplasm,Neoplasms,Neoplastic,Neural Networks (Computer),Non-U.S. Gov't,Oligonucleotide Array Sequence Analysis,P.H.S.,Privacy,Research Support,Rhabdomyosarcoma,Sarcoma,Small Cell,Software,U.S. Gov't},
  file = {/Users/staal/Documents/Zotero/storage/26TPF5RW/amia02-weber.pdf;/Users/staal/Documents/Zotero/storage/FRPABBPG/amia02-weber.pdf;/Users/staal/Documents/Zotero/storage/GME7HZA7/amia02-weber.pdf}
}

@article{coleman_endemic_2001,
	title = {Endemic stability--a veterinary idea applied to human public health.},
	volume = {357},
	issn = {0140-6736 0140-6736},
	abstract = {Endemic stability is an epidemiological state of a population, in which clinical  disease is scarce despite high level of infection. The notion was developed to describe patterns of tick-borne disease in cattle. However, we propose a general  model of endemic stability that is applicable to a broader range of diseases that are important in public health, including malaria, rubella, and mumps. We postulate that endemic stability requires only that (1) the probability, or severity, of clinical disease after infection increases with age, and (2) after one infection, the probability that subsequent infections result in disease is reduced. We present these criteria in simple mathematical terms. Our hypothesis predicts that partial disease control activities might, under certain circumstances, lead to an increase in disease incidence. We discuss the implications for public health interventions.},
	language = {eng},
	number = {9264},
	journal = {Lancet (London, England)},
	author = {Coleman, P. G. and Perry, B. D. and Woolhouse, M. E.},
	month = apr,
	year = {2001},
	pmid = {11418173},
	keywords = {*Endemic Diseases, *Epidemiologic Methods, *Models, Theoretical, *Public Health, Age Distribution, Animals, Child, Preschool, Communicable Diseases/*epidemiology/etiology, Humans, Incidence, Infant, Infant, Newborn},
	pages = {1284--1286}
}

Website  abstract   bibtex   

@article{
 title = {Grounding spatial language in perception: an empirical and computational investigation.},
 type = {article},
 year = {2001},
 identifiers = {[object Object]},
 keywords = {Adult,Discrimination Learning,Female,Humans,Male,Orientation,Pattern Recognition, Visual,Psycholinguistics,Semantics,Space Perception,Verbal Learning},
 pages = {273-98},
 volume = {130},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11409104},
 month = {6},
 id = {f03a3f85-fc38-3a50-8e63-ac6586b9fb9c},
 created = {2017-09-01T15:53:20.987Z},
 accessed = {2016-01-30},
 file_attached = {false},
 profile_id = {80da7853-f7b7-36a9-8e4c-d7ddb2d9e538},
 group_id = {a2333ea3-15a4-3d40-8d36-f0d9590ca926},
 last_modified = {2017-09-01T15:53:21.069Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Regier2001},
 abstract = {The present paper grounds the linguistic cdategorization of space in aspects of visual perception; specifically, the structure of projective spatial terms such as above are grounded in the process of attention and in vector-sum coding of overall direction. This is formalized in the attentional vector-sum (AVS) model. This computational model accurately predicts linguistic acceptability judgments for spatial terms, under a variety of spatial configurations. In 7 experiments, the predictions of the AVS model are tested against those of 3 competing models. The results support the AVS model and disconfirm its competitors. The authors conclude that the structure of linguistic spatial categories can be partially explained in terms of independently motivated perceptual processes.},
 bibtype = {article},
 author = {Regier, T and Carlson, L A},
 journal = {Journal of experimental psychology. General},
 number = {2}
}

@article{garcia_rodriguez_risk_2001,
	title = {The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents},
	volume = {3},
	issn = {1465-9905},
	doi = {10.1186/ar146},
	abstract = {Most anti-inflammatory drugs have been associated with an increased risk of serious upper gastrointestinal complications. Epidemiological studies have estimated the magnitude of the risk for specific anti-inflammatory drugs. The risk of upper gastrointestinal tract bleeding or perforation increases around twofold with use of oral steroids or low dose aspirin, and increases around fourfold with use of nonaspirin nonsteroidal anti-inflammatory drugs. Acetaminophen at daily doses of 2000 mg and higher has also been associated with an increased risk. Overall, the risk is dose dependent and is greater with more than one anti-inflammatory drug taken simultaneously. Hence, whenever possible, anti-inflammatory drugs should be given in monotherapy and at the lowest effective dose in order to reduce the risk of serious upper gastrointestinal complications.},
	language = {eng},
	number = {2},
	journal = {Arthritis Research},
	author = {Garcia Rodríguez, L. A. and Hernández-Díaz, S.},
	year = {2001},
	pmid = {11178116},
	pmcid = {PMC128885},
	keywords = {Acetaminophen, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Drug Therapy, Combination, Gastrointestinal Diseases, Glucocorticoids, Humans, Risk Factors},
	pages = {98--101}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Determination of dioxins/furans and PCBs by quadrupole ion-trap gas chromatography-mass spectrometry.},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Animals,Furans,Furans: analysis,Furans: toxicity,Gas Chromatography-Mass Spectrometry,Gas Chromatography-Mass Spectrometry: instrumentat,Gas Chromatography-Mass Spectrometry: methods,Humans,Polychlorinated Biphenyls,Polychlorinated Biphenyls: analysis,Polychlorinated Biphenyls: toxicity,Tetrachlorodibenzodioxin,Tetrachlorodibenzodioxin: analogs & derivatives,Tetrachlorodibenzodioxin: analysis,Tetrachlorodibenzodioxin: toxicity},
 pages = {305-65},
 volume = {19},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11079247},
 id = {99906347-4120-3a61-9bc4-5bb2ae3a2e80},
 created = {2014-05-31T04:14:15.000Z},
 file_attached = {true},
 profile_id = {9edae5ec-3a23-3830-8934-2c27bef6ccbe},
 group_id = {63e349d6-2c70-3938-9e67-2f6483f6cbab},
 last_modified = {2014-11-19T06:02:42.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {The versatility and sensitivity of the quadrupole ion trap tandem mass spectrometer has been applied to the determination of polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs), and of polychlorinated biphenyls (PCBs). A brief introduction to the theory of ion confinement in a quadrupole ion trap permits discussion of ion trajectory stability, mass-selective ion ejection, the frequencies of ion motion, and the role of resonant excitation of ion motion. The tandem mass spectrometric examination of PCDDs and PCDFs eluting and co-eluting from a gas chromatographic column is described. Illustrative examples are given of the analysis of field samples containing PCDDs and PCDFs. A comparison is presented of the performance of each of a quadrupole ion trap tandem mass spectrometer, a triple stage quadrupole mass spectrometer, and a sector instrument of relatively high mass resolution for the determination of PCDDs and PCDFs. This comparison is made with respect to instrument tuning, calibration plots, detection limits, ion signals at low concentration, relative response factors, ionization cross-sections, and the examination of field samples. The application of quadrupole ion trap tandem mass spectrometry to the examination of PCBs is focused upon those PCB congeners that have the greatest toxicity. 39 congeners of the total of 209 PCB congeners have been identified as having the greatest toxicities. Chemical ionization has been used for the determination of co-eluting congeners #77 and #110 where the toxicity of the former is much greater than that of the latter. An analytical protocol, based on the variation of molecular ion fragmentation according to the degree (or absence) of chlorine ortho-substitution, has been proposed for distinguishing between toxic and nontoxic PCB congeners.},
 bibtype = {article},
 author = {Plomley, J B and Lausevic, M and March, R E},
 journal = {Mass spectrometry reviews},
 number = {5}
}

@article{van_staa_oral_2000,
	title = {Oral corticosteroids and fracture risk: relationship to daily and cumulative doses},
	volume = {39},
	issn = {1462-0324},
	shorttitle = {Oral corticosteroids and fracture risk},
	abstract = {OBJECTIVE: This study examined the effects of daily and cumulative oral corticosteroid doses on the risk of fractures.
METHODS: Information was obtained from the General Practice Research Database, which contains medical records of general practitioners in England and Wales. The study included 244 235 oral corticosteroid users and 244 235 controls.
RESULTS: Patients taking higher doses (at least 7. 5 mg daily of prednisolone or equivalent) had significantly increased risks of non-vertebral fracture [relative rate (RR)=1.44, 95\% confidence interval (CI) 1.34-1.54], hip fracture (RR=2.21, 95\% CI 1.85-2.64) and vertebral fracture (RR=2.83, 95\% CI 2.35-2.40) relative to patients using oral corticosteroids at lower doses (less than 2.5 mg per day). Fracture risk was also elevated among people with higher cumulative exposure to oral corticosteroids over the study period, but this effect was almost wholly removed by adjustment for daily dose, age, gender and other confounding variables.
CONCLUSIONS: These findings suggest that the adverse skeletal effects of oral corticosteroids manifest rapidly and are related to daily dose. The level of previous exposure to oral corticosteroids was not a strong determinant of the risk of fracture. Preventive measures against corticosteroid-induced osteoporosis should therefore be instituted as soon after the commencement of glucocorticoid therapy as possible.},
	language = {eng},
	number = {12},
	journal = {Rheumatology (Oxford, England)},
	author = {van Staa, T. P. and Leufkens, H. G. and Abenhaim, L. and Zhang, B. and Cooper, C.},
	month = dec,
	year = {2000},
	pmid = {11136882},
	keywords = {Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Dose-Response Relationship, Drug, Female, Fractures, Bone, Humans, Middle Aged, Osteoporosis, Registries, Risk Factors},
	pages = {1383--1389}
}

@article{ dickens_scope_2000,
  title = {The scope and limits of conscientious objection},
  volume = {71},
  issn = {0020-7292},
  abstract = {Principles of religious freedom protect physicians, nurses and others who refuse participation in medical procedures to which they hold conscientious objections. However, they cannot decline participation in procedures to save life or continuing health. Physicians who refuse to perform procedures on religious grounds must refer their patients to non-objecting practitioners. When physicians refuse to accept applicants as patients for procedures to which they object, governmental healthcare administrators must ensure that non-objecting providers are reasonably accessible. Nurses' conscientious objections to participate directly in procedures they find religiously offensive should be accommodated, but nurses cannot object to giving patients indirect aid. Medical and nursing students cannot object to be educated about procedures in which they would not participate, but may object to having to perform them under supervision. Hospitals cannot usually claim an institutional conscientious objection, nor discriminate against potential staff applicants who would not object to participation in particular procedures.},
  language = {eng},
  number = {1},
  journal = {International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics},
  author = {Dickens, B M and Cook, R J},
  month = {October},
  year = {2000},
  pmid = {11044548},
  keywords = {Abortion, Legal, Conscience, Ethics, Medical, Ethics, Nursing, Gynecology, Human Rights, Humans, Obstetrics, Patient Advocacy, Refusal to Treat, Religion and Medicine, Reproductive Techniques, Sterilization, Reproductive, United Nations},
  pages = {71--77}
}

Website  abstract   bibtex   

@article{
 title = {Multivariate frailty model with a major gene: application to genealogical data},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {*Genetic Predisposition to Disease,*Models, Genetic,Adolescent,Adult,Alleles,Child,Child, Preschool,Female,Genotype,Humans,Infant,Infant, Newborn,Longevity/*genetics,Male,Mathematical Computing,Multivariate Analysis,Quebec,Risk,Software,Survival Analysis},
 pages = {412-416},
 volume = {77},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11187585},
 id = {23588418-0e3c-33dd-b0e4-fed475556b34},
 created = {2017-06-19T13:44:21.917Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:22.080Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0926-9630<m:linebreak/>Journal Article</m:note>},
 abstract = {Multivariate survival models are shown to be appropriate for the analysis of the genetic and the environmental nature of a human life-span. Models which involve continuously distributed individual frailty, play an important role in the genetic analysis of an individual's susceptibility to disease and death. These models, however, are not appropriate for the detection of the effects of separate genes on survival. For this purpose we developed a 'major gene' frailty model of multivariate survival and applied it to simulated and real pedigree data. The analysis shows that this model can be used for the detection of the presence of major genes in the population and for the evaluation of the effects of such genes on survival.},
 bibtype = {article},
 author = {Begun, A and Desjardins, B and Iachine, I and Yashin, A},
 journal = {Stud Health Technol Inform}
}

@article{
 title = {In vivo penetration of experimentally produced clots by monoclonal antibodies},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Animals,Antibodies, Monoclonal/metabolism,Antibody Specificity,Autoradiography,Blood Coagulation/immunology,Disease Models, Animal,Fibrin/immunology,Fluorescent Antibody Technique,Humans,Immunoglobulin G/metabolism,Iodine Radioisotopes/diagnostic use,Jugular Veins/pathology,Phlebography,Protein Binding,Rabbits,Saphenous Vein/pathology,Sheep,Thrombosis/immunology/radiography,Time Factors},
 pages = {882-886},
 volume = {83},
 month = {6},
 city = {Royal Veterinary College, Hatfield, UK. f.mcevoy@swipnet.se},
 id = {e17cc696-c7cd-3a2f-822a-fbb9eea6c336},
 created = {2016-09-06T13:34:39.000Z},
 file_attached = {false},
 profile_id = {cacab941-be62-3845-982b-a7700857a11d},
 last_modified = {2016-09-07T14:54:39.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {LR: 20041117; PUBM: Print; JID: 7608063; 0 (Antibodies, Monoclonal); 0 (Immunoglobulin G); 0 (Iodine Radioisotopes); 9001-31-4 (Fibrin); ppublish},
 abstract = {Antifibrin monoclonal antibodies show potential as clot targeting agents for diagnosis and possibly therapy in thrombotic disease. To be effective the antibody must bind to the fibrin component of the clot. The ability of two antifibrin mabs (NIB 1H10 and NIB 12B3) to penetrate occlusive clots in vivo was investigated. Both mabs react with human fibrin but not with human fibrinogen nor with the fibrin or fibrinogen from the species used in this study. Two heterologous animal (sheep and rabbit) thrombus models were used. Clots in both cases were made within isolated vein segments using a mixture of human and native fibrinogen. The clots in sheep veins were observed radiographically and found to be occlusive for a mean of 4.2 +/- 2.2 days and thereafter appeared only partially occlusive. When targeted in their occlusive phase (131)I labelled mab accumulated in the clot reaching a maximum ratio of 1.82 +/- 0.42 when compared to counts in homologous sheep clots in the contralateral limb. It was confirmed in the rabbit jugular vein model that total occlusivity did not prevent antibody accumulation in the heterologous clot by injecting the fibrin specific mab 1H10 and examining the clot excised after 1, 6 and 24 h using immunofluorescence. In a further series of similar experiments (125)I labelled mab 1H10 was used and detected using autoradiography. Both sets of experiments indicated that penetration of occlusive clots by the antibody occurred and that considerable accumulation was present at 6 and 24 h. The results indicate that a circulating antibody can readily gain access to experimentally produced clots in occluded veins.},
 bibtype = {article},
 author = {McEvoy, F J and Edgell, T A and Webbon, P M and Gaffney, P J},
 journal = {Thrombosis and haemostasis},
 number = {6}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry},
 type = {article},
 year = {1999},
 identifiers = {[object Object]},
 keywords = {Base Sequence,Canada,Canada/ethnology,Canada: ethnology,DNA-Binding Proteins,DNA-Binding Proteins/*genetics,DNA-Binding Proteins: genetics,Ethnic Groups,Ethnic Groups/*genetics,Ethnic Groups: genetics,Female,France,France/ethnology,France: ethnology,Human,Humans,Louisiana,Male,Microsatellite Repeats,Microsatellite Repeats/*genetics,Microsatellite Repeats: genetics,Muscular Dystrophies,Muscular Dystrophies/*genetics,Muscular Dystrophies: genetics,Non-U.S. Gov't,Pedigree,Poly(A)-Binding Protein II,Support},
 pages = {477-481},
 volume = {86},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/10508991},
 month = {10},
 day = {29},
 id = {45d065a8-6799-3e6b-880b-3fa24b3356fa},
 created = {2017-06-19T13:42:02.365Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:42:02.505Z},
 tags = {04/09/07},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>        <m:bold>From Duplicate 1 ( </m:bold>                <m:bold>          </m:bold><m:bold><m:italic>Unique PABP2 mutations in &quot;Cajuns&quot; suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry</m:italic></m:bold><m:bold>        </m:bold>                <m:bold> - Scacheri, P C; Garcia, C; Hebert, R; Hoffman, E P )<m:linebreak/>        </m:bold>        <m:linebreak/>Journal Article<m:linebreak/>        <m:linebreak/>      </m:note>},
 abstract = {Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset autosomal dominant myopathy found world-wide, but with the highest incidence in French-Canadians. Short GCG expansions in the poly(A) binding protein 2 (PABP2) gene were identified recently as the molecular basis for OPMD in French-Canadians. All French-Canadian cases of OPMD have been traced to a single founder couple [Bouchard, 1997: Neuromuscul Disord 7(Suppl):S5-S11]. Cultural links between French-Canadians and Cajuns suggest that this same founder couple may have transmitted the OPMD mutation to Cajuns as well. To determine if OPMD patients from Louisiana share a founder effect with French-Canadian families, we collected blood samples and muscle biopsies from several Cajuns with OPMD for mutation and linkage studies. We found a unique 'GCA GCG GCG' insertion mutation in Cajuns. Consistent with these sequence data, we identified a disease haplotype in our Cajun families that is different from the ancestral haplotype defined in French-Canadians. These data prove that different founders introduced the PABP2 mutation to Cajuns and French-Canadians and lend support to emerging genealogical data suggesting that French-Canadians and Cajuns represent distinct immigrant groups from France.},
 bibtype = {article},
 author = {Scacheri, P C and Garcia, C and Hébert, R and Hoffman, E P and Hebert, R},
 journal = {Am J Med Genet},
 number = {5}
}

@article{
 title = {Visual-proprioceptive mapping in children with developmental coordination disorder},
 type = {article},
 year = {1999},
 identifiers = {[object Object]},
 keywords = {Case-Control Studies,Child,Female,Growth Disorders,Humans,Male,Motor Skills,Preschool,Proprioception,Vision,physiopathology,psychology},
 pages = {247-254},
 volume = {41},
 id = {2a1d6312-9620-3630-b63f-f17c2d8e07ef},
 created = {2016-01-12T14:17:48.000Z},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Developmental coordination disorder (DCD) occurs in a small but significant proportion of children who present with impaired body-eye coordination and show poor acquisition of motor skills. This study investigated the visual-proprioceptive mapping ability of children with DCD from a small selected group, with particular reference to the use of vision in matching tasks. The children with DCD in this study were significantly poorer than control children on all matching tasks. They seemed to have particular difficulty in cross-modal judgements that required the use of visual information to guide proprioceptive judgements of limb position. A distinction is drawn between tasks that can be achieved purely through sensory matching and those that require body-centred spatial judgements, suggesting that it is the latter that posits a particular difficulty for children with DCD},
 bibtype = {article},
 author = {Mon-Williams, M A and Wann, J P and Pascal, E},
 journal = {Developmental Medicine & Child Neurology},
 number = {4}
}

@article{otoole_measuring_1999,
	title = {Measuring and developing suturing technique with a virtual reality surgical simulator},
	volume = {189},
	issn = {1072-7515},
	abstract = {BACKGROUND

We have developed an interactive virtual reality (VR) surgical simulator for the training and assessment of suturing technique. The surgical simulator is comprised of surgical tools with force feedback, a 3-dimensional graphics visual display of the simulated surgical field, physics-based computer simulations of the tissues and tools, and software to measure and evaluate the trainee's performance.


STUDY DESIGN

This study uses the simulator to measure and compare the skills of 8 experienced vascular surgeons versus 12 medical students when performing a virtual reality suturing task. Eight parameters of the suturing task were measured: total tissue damage, accuracy of needle puncture, peak tissue tearing force, time to complete the task, damage to the surface of the tissue, angular error in needle technique, total distance traveled by the tool tip, and a measure of overall error. Three test conditions (dominant hand, nondominant hand, and 3-dimensional needle guide) were tested. Statistical significance was defined as a univariate two-sided p value {\textless} or = 0.05.


RESULTS

The surgeons' average performance was significantly better than the students' average performance for three of the measured parameters (total tissue damage, time to complete the task, and total distance traveled by the tool tip) for each of the test conditions. For the test condition most similar to surgery (using the dominant hand to suture) one additional parameter was also significantly different (the measure of overall error). The medical students showed improvements for 6 of the 7 parameters for which the users received feedback during the training process. The surgeons also had significant improvement for 4 of the 7 parameters. The students had a larger improvement than the surgeons for 6 of the parameters, but these differences were not statistically significant.


CONCLUSIONS

Data indicate differences between surgeon and nonsurgeon performance and in improvement in performance with training. One possible explanation for the superior performance of the surgeons is that their suturing skills applied well to the simulated suturing task. Additional research is required to confirm or deny the similarity between actual and simulated surgical tasks and the relevance of virtual reality surgical simulation to surgical skill assessment and training.},
	number = {1},
	journal = {Journal of the American College of Surgeons},
	author = {O'Toole, R V and Playter, R R and Krummel, T M and Blank, W C and Cornelius, N H and Roberts, W R and Bell, W J and Raibert, M},
	month = jul,
	year = {1999},
	pmid = {10401747},
	keywords = {Computer Simulation, Computer-Assisted Instruction, Educational Measurement, General Surgery, Humans, Models, Educational, Suture Techniques, User-Computer Interface, Vascular Surgical Procedures},
	pages = {114--127}
}

@article{daneman_value_1998,
	title = {The value of sonography, {CT} and air enema for detection of complicated {Meckel} diverticulum in children with nonspecific clinical presentation},
	volume = {28},
	issn = {0301-0449},
	doi = {10.1007/s002470050502},
	abstract = {BACKGROUND: Complicated Meckel diverticulum (MD) in children does not always present with painless rectal bleeding and its presentation can then produce a difficult diagnostic dilemma. In this clinical setting, sonography (US), CT or even air enema may be the first modality chosen to evaluate these children rather than the radionuclide Meckel scan (RNMS).
PURPOSE: To assess the value of US, CT and air enema for detection of complicated MD.
MATERIALS AND METHODS: Review of clinical, imaging, surgical and pathological findings in 64 children (55 males, 9 females) aged 4 days -14 years (mean = 3.7 years) with MD seen during an 8-year period, 1990-1997.
RESULTS: (a) In 33 patients with rectal bleeding, MD was detected on RNMS in 32. Ten of these 32 had other imaging studies, all of which were negative. (b) The other 31 patients, with varied clinical presentations, did not undergo RNMS. In these 31 and the 1 with a negative RNMS, 14 (44 \%) had imaging features highly suggestive for the diagnosis of MD on US in all 14, on CT in 1, and on air enema in 3. The radiological spectrum of the inflamed, hemorrhagic MD is illustrated.
CONCLUSION: The inflamed, hemorrhagic and the inverted, intussuscepted MD have a spectrum of features recognizable on US, CT and air enema. Some of these appearances are specific, others are not. Knowledge of and recognition of these features will facilitate detection of complicated MD in larger numbers of children presenting with symptoms other than the classic history of painless rectal bleeding and also in those with normal RNMS.},
	language = {eng},
	number = {12},
	journal = {Pediatric Radiology},
	author = {Daneman, A. and Lobo, E. and Alton, D. J. and Shuckett, B.},
	month = dec,
	year = {1998},
	pmid = {9880634},
	keywords = {Adolescent, Child, Child, Preschool, Enema, Female, Humans, Infant, Infant, Newborn, Male, Meckel Diverticulum, Pneumoradiography, Retrospective Studies, Tomography, X-Ray Computed, ultrasonography},
	pages = {928--932}
}

@article{hippisley-cox_are_1998,
	title = {Are spouses of patients with hypertension at increased risk of having hypertension? {A} population-based case-control study},
	volume = {48},
	issn = {0960-1643},
	shorttitle = {Are spouses of patients with hypertension at increased risk of having hypertension?},
	abstract = {BACKGROUND: Studies of couples, who tend to share an environment but are genetically dissimilar, can shed light on the contribution of environmental factors to hypertension. There has been renewed interest in these environmental factors following the re-analysis of the INTERSALT study.
AIM: To determine whether patients whose spouses have hypertension are at increased risk of hypertension, using a population-based case-control study.
METHOD: The total study population consisted of all 3923 patients over 30 years old registered with one general practice. Male cases with hypertension were matched to male controls without hypertension. Female cases with hypertension were matched to female controls without hypertension. The variables were: diagnosed hypertension; having a spouse with diagnosed hypertension; age; sex; weight; height; body-mass index; couple status; diabetes; and systolic and diastolic blood pressure readings.
RESULTS: On multivariate analysis, when age, body-mass index, diabetes, couple status, and having a blood pressure reading were included, men whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted odds ratio (OR) 2.24; 95\% CI 1.77-2.72; P = 0.001). Similarly, on multivariate analysis, women whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted OR = 2.23; 95\% CI 1.75-2.72; P = 0.001). The risk for both male and female subjects persisted after adjustment for other variables. There was a significant correlation between systolic (r = 0.41; P {\textless} 0.0001) and diastolic (r = 0.25; P {\textless} 0.0001) blood pressures between spouse pairs.
CONCLUSION: The independent association between having a spouse with hypertension and increased risk of hypertension supports the view that there are significant environmental factors in the aetiology of hypertension. The finding has implications for the screening and treatment of hypertension in primary care.},
	language = {eng},
	number = {434},
	journal = {The British Journal of General Practice: The Journal of the Royal College of General Practitioners},
	author = {Hippisley-Cox, J. and Pringle, M.},
	month = sep,
	year = {1998},
	pmid = {9830183},
	pmcid = {PMC1313221},
	keywords = {Adult, Analysis of Variance, Case-Control Studies, England, Female, Humans, Hypertension, Male, Risk Assessment, Risk Factors, Rural Health, Spouses},
	pages = {1580--1583}
}

@article{van_staa_postmarketing_1998,
	title = {Postmarketing surveillance of the safety of cyclic etidronate},
	volume = {18},
	issn = {0277-0008},
	abstract = {To evaluate the safety of cyclic etidronate in routine clinical practice, we obtained information from 550 general practices in the United Kingdom that provide the medical records to the General Practice Research Database. A group of 7977 patients taking cyclic etidronate and two age-, gender-, and practice-matched control groups, one with osteoporosis and one without, were analyzed. For the group taking cyclic etidronate, the average age was 71.6 years and follow-up was 10,328 person-years. Conditions that do not induce osteoporosis generally occurred in these patients at a rate comparable to that in the control groups. The incidence of osteomalacia was low and comparable between patients taking cyclic etidronate and controls with osteoporosis. No medically significant increases in frequency were observed among patients taking cyclic etidronate for a broad group of diseases that may potentially be induced by exposure to the drug. These data support the favorable risk:benefit ratio of cyclic etidronate.},
	language = {eng},
	number = {5},
	journal = {Pharmacotherapy},
	author = {van Staa, T. P. and Leufkens, H. and Abenhaim, L. and Cooper, C.},
	month = oct,
	year = {1998},
	pmid = {9758324},
	keywords = {Aged, Cohort Studies, Etidronic Acid, Female, Great Britain, Humans, Male, Osteoporosis, Product Surveillance, Postmarketing, Quality Control, Retrospective Studies},
	pages = {1121--1128}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Policy reform dilemmas in promoting employment of persons with severe mental illness.},
 type = {article},
 year = {1998},
 identifiers = {[object Object]},
 keywords = {Cost-Benefit Analysis,Financing, Government,Financing, Government: economics,Financing, Government: legislation & jurisprudence,Health Care Reform,Health Care Reform: economics,Health Care Reform: legislation & jurisprudence,Health Policy,Health Policy: economics,Health Policy: legislation & jurisprudence,Humans,Psychotic Disorders,Psychotic Disorders: rehabilitation,Rehabilitation, Vocational,Rehabilitation, Vocational: economics,United States},
 pages = {775-81},
 volume = {49},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/9634156},
 id = {e12d891f-a3a6-39d2-9a49-cf25d79231b0},
 created = {2019-04-06T18:16:10.399Z},
 accessed = {2018-03-09},
 file_attached = {true},
 profile_id = {bfdd6dfc-f1a1-3f60-afba-6d90526c6e72},
 group_id = {de34baf0-a50f-373e-9c85-1ffe979e98ec},
 last_modified = {2019-04-06T18:16:10.698Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Noble1998},
 folder_uuids = {04be9370-e1fc-4641-b78e-e1622f7005c6},
 private_publication = {false},
 abstract = {Recent evaluations by the U.S. General Accounting Office and the National Alliance for the Mentally Ill of reemployment efforts of the federal-state vocational rehabilitation program found that services offered by state vocational rehabilitation agencies do not produce long-term earnings for clients with emotional or physical disabilities. This paper examines reasons for these poor outcomes and the implications of recent policy reform recommendations. Congress must decide whether to take action at the federal level to upgrade programs affecting persons with severe mental illnesses or to continue to rely on state decision making. The federal-state program largely wastes an estimated $490 million annually on time-limited services to consumers with mental illnesses. Rechanneled into a variety of innovative and more appropriate integrated services models, the money could buy stable annual vocational rehabilitation funding for 62,000 to 90,000 consumers with severe mental illnesses. Larger macrosystem problems involve the dynamics of the labor market that limit job opportunities and the powerful work disincentives for consumers with severe disabilities now inherent in Social Security Disability Insurance, Supplemental Security Income, Medicare, and Medicaid.},
 bibtype = {article},
 author = {Noble, J H},
 journal = {Psychiatric services (Washington, D.C.)},
 number = {6}
}

Website  abstract   bibtex   

@article{
 title = {Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group},
 type = {article},
 year = {1996},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Age Distribution,Aged,Aged, 80 and over,Allergens/diagnostic use,Asthma/epidemiology/*genetics,Atlantic Ocean,Bronchoconstrictor Agents/diagnostic use,Child,Child, Preschool,Consanguinity,Female,Forced Expiratory Volume,Founder Effect,Humans,Linkage (Genetics),Male,Methacholine Chloride/diagnostic use,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Sex Distribution,Skin Tests},
 pages = {1902-1906},
 volume = {153},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8665053},
 id = {ba377ad3-36ac-3937-b8d3-44f6b08c99e3},
 created = {2017-06-19T13:44:45.103Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:45.287Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1073-449x<m:linebreak/>Journal Article</m:note>},
 abstract = {Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus increasing the probability of gene localization. We studied the inbred population of the remote island of Tristan da Cunha to document asthma prevalence for the purpose of genetic linkage analysis. Medical histories and skin atopy were determined on 282 islanders, representing 97% of the population, and airway responsiveness was measured in 254; 226 by methacholine challenge (tidal breathing method) and 28 by bronchodilator response (400 micrograms salbutamol aerosol). Blood samples were collected from 275 islanders. Participants ranged in age from 3 to 94 yr. Asthma was defined as increased airway responsiveness (AR+: PC20 < 4 mg/ml or > or = 15% increase in FEV1 postbronchodilator) combined with a positive history (Hx+). Fifty-seven percent of the islanders had at least partial evidence of asthma (Hx+ and/or AR+) and 23% had a definitive diagnosis of asthma (AR+ with Hx+). Overall 47% of the population were atopic, atopy was proportionally higher in asthmatics (74%) than nonasthmatics (32%; p < 0.01). Analysis of the methacholine dose-response curves demonstrated that asthmatics were significantly (p < 0.01) more responsive than those with AR+ only, and nonasthmatics (AR-, Hx-) were more responsive than laboratory control subjects (p < 0.05), suggesting that these islanders may also carry an airway hyperresponsiveness gene. A frequency plot of the percent fall in FEV1 for all Hx- subjects compared with control data suggests a bimodal distribution consistent with a major gene mechanism for airway responsiveness. Genealogy mapping revealed that the islanders are direct descendants of the 15 original settlers, and historical records suggest at least two founders may have been asthmatic. The data confirm previous reports of a high asthma prevalence on Tristan and support the postulate that this prevalence is a result of gene enrichment occurring in isolated populations by virtue of extensive inbreeding and a probable founder effect.},
 bibtype = {article},
 author = {Zamel, N and McClean, P A and Sandell, P R and Siminovitch, K A and Slutsky, A S},
 journal = {Am J Respir Crit Care Med},
 number = {6 Pt 1}
}

@article{boon_congenital_1995,
	title = {Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases},
	volume = {30},
	issn = {0022-3468},
	shorttitle = {Congenital fibrosarcoma masquerading as congenital hemangioma},
	abstract = {The authors report on two infants who had large congenital fibrosarcomas that initially were believed to be hemangiomas. Although hemangioma and congenital fibrosarcoma can have a similar presentation, their treatment is dissimilar. The authors review the anatomic findings, hematologic differences, and radiological clues that can help to differentiate congenital fibrosarcoma from congenital hemangioma.},
	language = {eng},
	number = {9},
	journal = {Journal of Pediatric Surgery},
	author = {Boon, L. M. and Fishman, S. J. and Lund, D. P. and Mulliken, J. B.},
	month = sep,
	year = {1995},
	pmid = {8523253},
	keywords = {Diagnosis, Differential, Female, Fibrosarcoma, Hemangioma, Humans, Infant, Newborn, Male, Neck, Shoulder, Skin Neoplasms},
	pages = {1378--1381}
}

@Article{Nakashima_1994_1801,
  author = {Nakashima, Y. and Plump, A. S. and Raines, E. W. and Breslow, J. L. and Ross, R.},
 journal = {Arterioscler.Thromb.},
 note = {DA - 19940204 NOT IN FILE},
 number = {1},
 pages = {133-140},
 title = {Apoe-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree},
 volume = {14},
 year = {1994},
 keywords = {Animals, Aorta, Aorta, Thoracic, Apolipoproteins, E, Arteries, Arteriosclerosis, Atherosclerosis, Carotid, Arteries, Connective, Tissue, Coronary, Vessels, deficiency, Diet, Endothelium, Vascular, etiology, Humans, Hypercholesterolemia, Leukocytes, Mononuclear, Macrophages, Mice, Mice, Inbred, BALB, C, Mice, Inbred, C57BL, Mice, Transgenic, Microscopy, Electron, pathology, Pulmonary, Artery, Research, Support, Non-U.S.Gov't, Research, Support, U.S.Gov't, P.H.S., therapy},
 title_with_no_special_chars = {ApoEdeficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree}
}

@article{cobby_deep_1992,
	title = {The deep lateral femoral notch: an indirect sign of a torn anterior cruciate ligament},
	volume = {184},
	issn = {0033-8419},
	shorttitle = {The deep lateral femoral notch},
	abstract = {Magnetic resonance (MR) imaging has shown that tears of the anterior cruciate ligament (ACL) are frequently accompanied by meniscal and osseous injuries. Abnormalities of the cartilage overlying the lateral femoral condylopatellar sulcus (notch) also have been noted during arthrotomy of ACL-deficient knees. In this study, the appearance of this sulcus on MR images and the depth of the sulcus on conventional radiographs are compared in patients with normal and torn ACLs to determine whether a deep sulcus is a useful indirect sign of a torn ACL. In 62 patients with clinically and/or arthroscopically confirmed normal ACLs, the mean depth of the lateral femoral sulcus was 0.45 mm (range, 0.0-1.2 mm) compared with 0.89 mm (range, 0.0-5.0 mm) in 41 patients with clinically and/or arthroscopically confirmed ACL tears (significant at the 5\% level). No patient with a normal ACL had a sulcus greater than 1.2 mm in depth. A sulcus deeper than 1.5 mm is equivalent to 3 standard deviations above the mean and was a reliable indirect sign of a torn ACL.},
	number = {3},
	journal = {Radiology},
	author = {Cobby, M J and Schweitzer, M E and Resnick, D},
	month = sep,
	year = {1992},
	pmid = {1509079},
	keywords = {Adolescent, Adult, Aged, Anterior Cruciate Ligament, Female, Femur, Humans, Knee Joint, Magnetic Resonance Imaging, Male, Middle Aged, knee injuries},
	pages = {855--858}
}

@Article{Farb_1990_1874,
  author = {Farb, A. and Virmani, R. and Atkinson, J. B. and Kolodgie, F. D.},
 journal = {J.Am.Coll.Cardiol.},
 note = {DA - 19901227 NOT IN FILE},
 number = {6},
 pages = {1421-1429},
 title = {Plaque morphology and pathologic changes in arteries from patients dying after coronary balloon angioplasty},
 volume = {16},
 year = {1990},
 keywords = {Aged, Angioplasty, Transluminal, Percutaneous, Coronary, Arteries, Autopsy, Coronary, Arteriosclerosis, Coronary, Vessels, Humans, Male, Middle, Aged, mortality, pathology, Retrospective, Studies, Survival, Analysis, therapy},
 title_with_no_special_chars = {Plaque morphology and pathologic changes in arteries from patients dying after coronary balloon angioplasty}
}

@article{harvell_diagnostic_1989,
	title = {Diagnostic arthroscopy of the knee in children and adolescents},
	volume = {12},
	issn = {0147-7447},
	abstract = {There is a definite role for arthroscopy in the diagnosis and treatment of problem knees in children and adolescents. In this series, the largest reported to date, significant intraarticular pathology frequently existed in both preadolescent and adolescent groups. Three hundred ten knee arthroscopies in 285 children were reviewed. Preoperative clinical diagnoses were correlated with arthroscopic findings. In preadolescents (12 years old and younger), only 55\% of preoperative clinical diagnoses were confirmed at surgery. Thirty-five percent of this group were found to have additional pathology not anticipated preoperatively. In adolescents (13 to 18 years old), 70\% of clinical diagnoses were confirmed arthroscopically. Additional pathology was also found on arthroscopic examination in 25\% of this group.},
	language = {eng},
	number = {12},
	journal = {Orthopedics},
	author = {Harvell, Jr, J C and Fu, F H and Stanitski, C L},
	month = dec,
	year = {1989},
	pmid = {2594588},
	note = {00000 },
	keywords = {Adolescent, Arthroscopy, Cartilage Diseases, Child, Child, Preschool, Female, Humans, Infant, Joint Diseases, Knee Joint, Male, Retrospective Studies, knee injuries},
	pages = {1555--1560}
}

@article{maurer_intergroup_1988,
	title = {The {Intergroup} {Rhabdomyosarcoma} {Study}-{I}. {A} final report},
	volume = {61},
	issn = {0008-543X},
	abstract = {The results of treatment of 686, previously untreated patients younger than 21 years with rhabdomyosarcoma or undifferentiated sarcoma, who were entered on Intergroup Rhabdomyosarcoma Study-I (IRS-I) were analyzed after a minimum potential follow-up time of 7 years. Patients in Clinical Group I (localized disease, completely resected) were randomized to receive either vincristine, dactinomycin, and cyclophosphamide (VAC) or VAC + radiation. At 5 years, approximately 80\% of patients given either treatment were still disease-free and there was no significant difference between treatments in the overall percentages of patients surviving of 93\% and 81\%, respectively (P = 0.67). Patients in Clinical Group II (regional disease, grossly resected) were randomized to receive either vincristine and dactinomycin (VA) + radiation or VAC + radiation. At 5 years, 72\% and 65\% of the patients, respectively, were disease-free and there was no evidence of a difference between treatments (P = 0.46). The overall survival percentage at 5 years was approximately 72\% for both treatments. Patients in Clinical Groups III (gross residual disease after surgery) and IV (metastatic disease) were randomized to receive either "pulse" VAC + radiation or "pulse" VAC + Adriamycin (doxorubicin) + radiation. The complete remission (CR) rate was 69\% in Clinical Group III and 50\% in IV, with no statistically significant difference in CR rates between treatments in either group. Those who achieved a CR had a nearly 60\% chance of staying in remission for 5 years in Clinical Group III compared with approximately 30\% in Clinical Group IV. The overall survival percentage at 5 years was 52\% in Clinical Group III compared to 20\% in Clinical Group IV (P less than 0.0001). The 5-year survival percentage for the entire cohort of 686 patients was 55\%. Survival after relapse was poor, being 32\% at 1 year and 17\% at 2 years. The risk of distant metastasis was much greater than the risk of local recurrence within each clinical group, and there was no evidence of differing types of relapses between treatments. Primary tumors of the orbit and genitourinary tract carried the best prognosis, whereas tumors of the retroperitoneum had the worst prognosis. The authors conclude that for the therapeutic regimens evaluated there was no therapeutic advantage to including radiation in the treatment of Clinical Group I disease, or cyclophosphamide given as a daily low-dose oral regimen in the treatment of Clinical Group II disease or Adriamycin in the treatment of Clinical Groups III and IV diseases.},
	language = {eng},
	number = {2},
	journal = {Cancer},
	author = {Maurer, H. M. and Beltangady, M. and Gehan, E. A. and Crist, W. and Hammond, D. and Hays, D. M. and Heyn, R. and Lawrence, W. and Newton, W. and Ortega, J.},
	month = jan,
	year = {1988},
	pmid = {3275486},
	keywords = {Adolescent, Antineoplastic Combined Chemotherapy Protocols, Child, Child, Preschool, Clinical Trials as Topic, Combined Modality Therapy, Cyclophosphamide, Dactinomycin, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Female, Follow-Up Studies, Humans, Infant, Male, Prognosis, Random Allocation, Rhabdomyosarcoma, Vincristine},
	pages = {209--220}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Correcting misconceptions in mental health policy: strategies for improved care of the seriously mentally ill.},
 type = {article},
 year = {1987},
 identifiers = {[object Object]},
 keywords = {20th Century,Community Mental Health Services,Deinstitutionalization,Disability Evaluation,Health Policy,Health Policy: history,History,Humans,Medicaid,Mental Disorders,Mental Disorders: therapy,Mental Health,Mental Health Services,Mental Health Services: history,Mental Health: history,Patient Advocacy,United States},
 pages = {203-30},
 volume = {65},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/3302647},
 id = {989d73f4-2d97-3787-b1d3-476f140d85ff},
 created = {2019-04-06T18:15:11.167Z},
 accessed = {2018-03-09},
 file_attached = {true},
 profile_id = {bfdd6dfc-f1a1-3f60-afba-6d90526c6e72},
 group_id = {de34baf0-a50f-373e-9c85-1ffe979e98ec},
 last_modified = {2019-04-06T18:15:11.390Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Mechanic1987},
 folder_uuids = {04be9370-e1fc-4641-b78e-e1622f7005c6},
 private_publication = {false},
 abstract = {In the decades immediately following World War II a strong coalition of professionals and reformers emerged to shape agendas, debates, and national policy on caring for the mentally ill. The heterogeneity of mental health problems, the demographic shifts in populations at risk, and the realities of designing and implementing effective programs, were often overlooked; yet profound elements of change have taken place. Components essential for maintenance of function and rehabilitation have yet to be linked into a responsible alternative to long-term or episodic hospital care.},
 bibtype = {article},
 author = {Mechanic, D},
 journal = {The Milbank quarterly},
 number = {2}
}

@article{
 title = {Frequency and intensity discrimination in humans and monkeys},
 type = {article},
 year = {1985},
 keywords = {Acoustic Stimulation,Adult,Animals,Auditory Perception/physiology,Cercopithecus aethiops/physiology,Female,Humans,Macaca/physiology,Male,Species Specificity,Speech Acoustics,Speech Perception/physiology,Vestibulocochlear Nerve/physiology},
 pages = {1977-1985},
 volume = {78},
 id = {163a1c5d-06e6-3686-9f07-6e1f76a6fc88},
 created = {2017-09-01T15:54:31.569Z},
 file_attached = {false},
 profile_id = {80da7853-f7b7-36a9-8e4c-d7ddb2d9e538},
 group_id = {a2333ea3-15a4-3d40-8d36-f0d9590ca926},
 last_modified = {2017-09-01T15:54:31.713Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 language = {eng},
 abstract = {Frequency and intensity DLs were compared in humans and monkeys using a repeating standard "yes-no" procedure in which subjects reported frequency increments, frequency decrements, intensity increments, or intensity decrements in an ongoing train of 1.0-kHz tone bursts. There was only one experimental condition (intensity increments) in which monkey DLs (1.5-2.0 dB) overlapped those of humans (1.0-1.8 dB). For discrimination of both increments and decrements in frequency, monkey DLs (16-33 Hz) were approximately seven times larger than those of humans (2.4-4.8 Hz), and for discrimination of intensity decrements, monkey DLs (4.4-7.0 dB) were very unstable and larger than those of humans (1.0-1.8 dB). For intensity increment discrimination, humans and monkeys also exhibited similar DLs as SL was varied. However, for frequency increment discrimination, best DLs for humans occurred at a high (50 dB) SL, whereas best DLs for monkeys occurred at a moderate (30 dB) SL. Results are discussed in terms of various neural mechanisms that might be differentially engaged by humans and monkeys in performing these tasks; for example, different amounts of temporal versus rate coding in frequency discrimination, and different mechanisms for monitoring rate decreases in intensity discrimination. The implications of these data for using monkeys as models of human speech sound discrimination are also discussed.},
 bibtype = {article},
 author = {Sinnott, J. and Petersen, M. and Hopp, S.},
 number = {6}
}

@article{ikeuchi_arthroscopic_1982,
	title = {Arthroscopic treatment of the discoid lateral meniscus. {Technique} and long-term results},
	issn = {0009-921X},
	abstract = {Forty-five patients (49 knees) who had torn complete or incomplete discoid lateral menisci were treated during the period from 1968 to 1980. Both instrumentation and specific techniques considerably evolved in the arthroscopic complete excision the torn discoid meniscus. The current technique involves the initial removal of the anterior portion of the meniscus, as this allows clearer visualization during the procedure, more space for manipulating surgical instruments, and a reduced operative time. Twenty-four knees (22 patients) were followed for a mean of four years three months. Of this group, 78\% were rated excellent or good and 21\% were rated fair. There were no poor results. The results in the group treated by total meniscectomy were better than those in the group treated with partial meniscectomy. Three patients were treated by peripheral meniscal repair under arthroscopic control, but the long-term results are not available.},
	language = {eng},
	number = {167},
	journal = {Clinical orthopaedics and related research},
	author = {Ikeuchi, H},
	month = jul,
	year = {1982},
	pmid = {6896480},
	keywords = {Adolescent, Adult, Arthroscopy, Female, Follow-Up Studies, Humans, Knee Joint, Male, Menisci, Tibial, Methods, Middle Aged, Postoperative Complications},
	pages = {19--28}
}

@Article{Potter1975,
  author   = {Mary C. Potter},
  journal  = {Science},
  title    = {Meaning in visual search.},
  year     = {1975},
  number   = {4180},
  pages    = {965-6},
  volume   = {187},
  abstract = {Viewers briefly glimpsed pictures presented in a sequence at rates
	up to eight per second. They recognized a target picture as accurately
	and almost as rapidly when they knew only its meaning given by a
	name (for example, a boat) as when they had seen the picture itself
	in advance.},
  keywords = {Adult, Form Perception, Humans, Memory, Pattern Recognition, Reaction Time, Visual, 1145183},
}