@article{oldfield_experiences_2022,
	title = {Experiences, patient interactions and knowledge regarding the use of cannabis as a medicine in a cohort of {New} {Zealand} doctors in an oncology setting},
	volume = {98},
	issn = {1469-0756},
	doi = {10.1136/postgradmedj-2020-139013},
	abstract = {PURPOSE OF STUDY: To explore the experiences, patient interactions and knowledge regarding the use of cannabis as a medicine in New Zealand doctors in an oncology setting.
STUDY DESIGN: An observational cross-sectional survey undertaken between November 2019 and January 2020 across four secondary-care hospital oncology departments within New Zealand (Auckland, Wellington, Christchurch and Dunedin). Participants were a convenience sample of doctors; consultants, registrars, medical officers of special status and house surgeons working in oncology departments. Of 53 individuals approached, 45 participated (85\% Response Rate). The primary outcome was reporteddoctor-patient interactions. Secondary outcomes included knowledge of cannabis-based products, their efficacy, prescribing regulations and educational access.
RESULTS: Of 44 doctors, 37 (84\%, 95\% CI: 70 to 93) reported patient requests to prescribe cannabis-based products and 43 (98\%, 95\% CI: 88 to 100) reported patients using illicit cannabis for medical symptoms. Primary request reasons were pain, nausea/vomiting and cancer treatment. 33/45 (73\%, 95\% CI: 58 to 85) cited knowledge of at least one cannabis-based product and 27/45 (60\%, 95\% CI: 44 to 74) indicated at least one condition that had evidence of efficacy. 36/44 (82\%, 95\% CI: 67 to 92) expressed future prescribing concerns but all were willing to use a cannabis-based product developed with traditional medical provenance.
CONCLUSION: In the oncology setting, patients are asking doctors about symptomatic and curative treatment with cannabis-based products. Doctors are not biased against the use of products showing medical provenance; however, NZ-specific clinical and regulatory guidelines are essential to support patient discussions and appropriate prescribing.},
	language = {eng},
	number = {1155},
	journal = {Postgraduate Medical Journal},
	author = {Oldfield, Karen and Eathorne, Allie and Tewhaiti-Smith, Jordan and Beasley, Richard and Semprini, Alex and Braithwaite, Irene},
	month = jan,
	year = {2022},
	pmid = {33218966},
	keywords = {Adult, Aged, Attitude of Health Personnel, Cannabis, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Medical Marijuana, Medicine, Middle Aged, Neoplasms, New Zealand, Oncology, Physician-Patient Relations, Physicians, chemotherapy, complementary medicine, education \& training (see medical education \& training), pain management},
	pages = {35--42},
}

@article{rao_global_2022,
	title = {A {Global} {Survey} of {Ethnic} {Indian} {Women} {Living} with {Polycystic} {Ovary} {Syndrome}: {Co}-{Morbidities}, {Concerns}, {Diagnosis} {Experiences}, {Quality} of {Life}, and {Use} of {Treatment} {Methods}},
	volume = {19},
	issn = {1660-4601},
	shorttitle = {A {Global} {Survey} of {Ethnic} {Indian} {Women} {Living} with {Polycystic} {Ovary} {Syndrome}},
	doi = {10.3390/ijerph192315850},
	abstract = {BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is highly prevalent in women of Indian ethnicity. Clinical practice guidelines do not adequately consider ethnic-cultural differences in the diagnosing and care of women with PCOS. This study aimed to understand co-morbidities, key concerns, quality of life (QoL), and diagnosis experiences of ethnic Indian women living with PCOS.
METHODS: Global online survey of ethnic Indian women of reproductive age living with PCOS.
RESULTS: Respondents (n = 4409) had a mean age of 26.8 (SD 5.5) years and reported having a family history of type 2 diabetes (43\%) and PCOS (18\%). Most of them (64\%) were diagnosed with one or more co-morbidities (anxiety/depression being the most common). Irregular periods, cysts on the ovaries, and excess unwanted facial hair growth were their three top concerns. On average, women experienced symptoms of PCOS at the age of 19.0 (SD 5.0) and were diagnosed at the age of 20.8 years (SD 4.8). We report a one-year delay in seeking medical help and a seven-month diagnostic delay, which were associated with poor satisfaction with the information provided related to PCOS and its treatment options (p {\textless} 0.01). Women living outside India reported difficulty losing weight as their most key concern; however, they had higher dissatisfaction with the information provided on diet (OR, 0.74; 95\% CI, 0.6 to 0.8; p = 0.002), exercise (OR, 0.74; 95\% CI, 0.6 to 0.9; p = 0.002) and behavioural advice (OR, 0.74; 95\% CI, 0.6 to 0.9; p = 0.004) than women living in India. Most women reported poor QoL in weight and emotion domains.
CONCLUSIONS: Ethnic Indian women experience early onset of PCOS symptoms and delay in seeking professional help. Timely diagnosis, providing cultural-specific education related to lifestyle and weight management, and improving psycho-emotional support are key areas that should be addressed in clinical practice and future research.},
	language = {eng},
	number = {23},
	journal = {International Journal of Environmental Research and Public Health},
	author = {Rao, Vibhuti Samarth and Cowan, Stephanie and Armour, Mike and Smith, Caroline A. and Cheema, Birinder S. and Moran, Lisa and Lim, Siew and Gupta, Sabrina and Manincor, Michael De and Sreedhar, Vikram and Ee, Carolyn},
	month = nov,
	year = {2022},
	pmid = {36497927},
	pmcid = {PMC9740300},
	keywords = {Adult, Delayed Diagnosis, Diabetes Mellitus, Type 2, Female, Humans, Indian migrant women, Indian women, Menstruation Disturbances, PCOS, Polycystic Ovary Syndrome, Quality of Life, Young Adult, diagnosis, key concerns, polycystic ovary syndrome, quality of life, satisfaction, survey, treatment methods},
	pages = {15850},
}

@article{hildebrandt_randomized_2020,
	title = {Randomized {Controlled} {Trial} {Comparing} {Health} {Coach}-{Delivered} {Smartphone}-{Guided} {Self}-{Help} {With} {Standard} {Care} for {Adults} {With} {Binge} {Eating}.},
	volume = {177},
	issn = {1535-7228 0002-953X},
	doi = {10/ghsrqp},
	abstract = {OBJECTIVE: Cognitive-behavioral therapy (CBT) has shown efficacy in the treatment of eating disorders. The authors conducted a randomized controlled telemedicine trial  of CBT-guided self-help (CBT-GSH) assisted with a smartphone app, Noom Monitor, for  binge eating with or without purging. They hypothesized that coach-delivered CBT-GSH  telemedicine sessions plus Noom Monitor would yield greater reductions in symptoms  of binge eating, purging, and eating disorders compared with standard care. METHODS:  Fifty-two-week outcomes for CBT-GSH plus Noom Monitor (N=114) were compared with  outcomes for standard care (N=111) among members of an integrated health care system  in the Pacific Northwest. Patients in the health system who met inclusion criteria  were ≥18 years old, had a body mass index ≥18.5, met criteria for DSM-5 binge eating  disorder or bulimia nervosa, had 12 months of continuous health care enrollment in  Kaiser Permanente Northwest, and had a personal smartphone. Participants received  eight CBT-GSH telemedicine sessions over 12 weeks administered by health coaches,  and outcomes were assessed at baseline and at weeks 4, 8, 12, 26, and 52. The use of  available treatment offered within the Kaiser Permanente health care system was  permitted for participants assigned to standard care. RESULTS: Participants who  received CBT-GSH plus Noom Monitor reported significant reductions in objective  binge-eating days (β=-0.66, 95\% CI=-1.06, -0.25; Cohen's d=-1.46, 95\% CI=-4.63,  -1.09) and achieved higher rates of remission (56.7\% compared with 30\%; number  needed to treat=3.74) at 52 weeks compared with participants in standard care, none  of whom received any eating disorder treatment during the intervention period  (baseline and weeks 1-12). Similar patterns emerged for compensatory behaviors  (vomiting, use of laxatives, and excessive exercise; 76.3\% compared with 56.8\%;  number needed to treat=5.11), eating disorder symptoms (body shape, weight, eating  concerns, and dietary restraint), and clinical impairment (Cohen's d=-10.07, -2.15).  CONCLUSIONS: These results suggest that CBT-GSH plus Noom Monitor delivered via  telemedicine by routine-practice health coaches in a nonacademic health care system  yields reductions in symptoms and impairment over 52 weeks compared with standard  care.},
	language = {eng},
	number = {2},
	journal = {The American journal of psychiatry},
	author = {Hildebrandt, Tom and Michaeledes, Andreas and Mayhew, Meghan and Greif, Rebecca and Sysko, Robyn and Toro-Ramos, Tatiana and DeBar, Lynn},
	month = feb,
	year = {2020},
	pmid = {32008396},
	note = {Place: United States},
	keywords = {*Cognitive, *Cognitive Behavioral Therapy, *Computers, *Eating Disorders, *Gender Differences, *Metabolism, *Obsessive-Compulsive Disorder, *Smartphone, Adolescent, Adult, Binge-Eating Disorder/*therapy, Female, Humans, Male, Mentoring, Middle Aged, Telemedicine/*methods, Young Adult},
	pages = {134--142},
}

@article{burt_marijuana_2020,
	title = {Marijuana use and coronary artery disease in young adults},
	volume = {15},
	issn = {1932-6203 (Electronic) 1932-6203 (Linking)},
	doi = {10.1371/journal.pone.0228326},
	abstract = {BACKGROUND: Marijuana is the most popular drug of abuse in the United States. The association between its use and coronary artery disease has not yet been fully elucidated. This study aims to determine the frequency of coronary artery disease among young to middle aged adults presenting with chest pain who currently use marijuana as compared to nonusers. METHODS: In this retrospective study, 1,420 patients with chest pain or angina equivalent were studied. Only men between 18 and 40 years and women between 18 and 50 years of age without history of cardiac disease were included. All patients were queried about current or prior cannabis use and underwent coronary CT angiography. Each coronary artery on coronary CT angiography was assessed based on the CAD-RADS reporting system. RESULTS: A total of 146 (10.3\%) out of 1,420 patients with chest pain were identified as marijuana users. Only 6.8\% of the 146 marijuana users had evidence of coronary artery disease on coronary CT angiography. In comparison, the rate was 15.0\% among the 1,274 marijuana nonusers (p = 0.008). After accounting for other cardiac risk factors in a multivariate analysis, the negative association between marijuana use and coronary artery disease on coronary CT angiography diminished (p = 0.12, 95\% CI 0.299-1.15). A majority of marijuana users were younger than nonusers and had a lower frequency of hypertension and diabetes than nonusers. There was no statistical difference in lipid panel values between the two groups. Only 2 out of 10 marijuana users with coronary artery disease on coronary CT angiography had hemodynamically significant stenosis. CONCLUSION: Among younger patients being evaluated for chest pain, self-reported cannabis use conferred no additional risk of coronary artery disease as detected on coronary CT angiography.},
	number = {1},
	journal = {PLoS One},
	author = {Burt, J. R. and Agha, A. M. and Yacoub, B. and Zahergivar, A. and Pepe, J.},
	year = {2020},
	pmcid = {PMC6988970},
	keywords = {Adult, Case-Control Studies, Computed Tomography Angiography, Coronary Artery Disease/diagnostic imaging/*epidemiology, Female, Humans, Male, Marijuana Use/adverse effects/*epidemiology, Middle Aged, Retrospective Studies, United States/epidemiology, Young Adult},
	pages = {e0228326},
}

Paper  doi  bibtex   

@article{jansen_burden_2020,
	title = {Burden of {Illness} and {Quality} of {Life} in {Tuberous} {Sclerosis} {Complex}: {Findings} {From} the {TOSCA} {Study}},
	volume = {11},
	issn = {16642295},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090896990&doi=10.3389%2ffneur.2020.00904&partnerID=40&md5=1faa143e97a93bf95e1228ed0c704c24},
	doi = {10.3389/fneur.2020.00904},
	language = {English},
	journal = {Frontiers in Neurology},
	author = {Jansen, A.C. and Vanclooster, S. and de Vries, P.J. and Fladrowski, C. and Beaure d'Augères, G. and Carter, T. and Belousova, E. and Benedik, M.P. and Cottin, V. and Curatolo, P. and Dahlin, M. and D'Amato, L. and Ferreira, J.C. and Feucht, M. and Hertzberg, C. and Jozwiak, S. and Lawson, J.A. and Macaya, A. and Marques, R. and Nabbout, R. and O'Callaghan, F. and Qin, J. and Sander, V. and Sauter, M. and Shah, S. and Takahashi, Y. and Touraine, R. and Youroukos, S. and Zonnenberg, B. and Kingswood, J.C. and Shinohara, N. and Horie, S. and Kubota, M. and Tohyama, J. and Imai, K. and Kaneda, M. and Kaneko, H. and Uchida, Y. and Kirino, T. and Endo, S. and Inoue, Y. and Uruno, K. and Serdaroglu, A. and Yapici, Z. and Anlar, B. and Altunbasak, S. and Lvova, O. and Belyaev, O.V.B. and Agranovich, O. and Levitina, E.V.L. and Maksimova, Y.V.M. and Karas, A. and Jiang, Y. and Zou, L. and Xu, K. and Zhang, Y. and Luan, G. and Zhang, Y. and Wang, Y. and Jin, M. and Ye, D. and Ye, D. and Zhou, L. and Liu, J. and Liao, J. and YAN, B. and Deng, Y. and Jiang, L. and Liu, Z. and Huang, S. and Li, H. and Kim, K. and Chen, P.-L. and Lee, H.-F. and Tsai, J.-D. and Chi, C.-S. and Huang, C.-C. and Riney, K. and Yates, D. and Kwan, P. and Likasitwattanakul, S. and Nabangchang, C. and Chomtho, L.T.K. and Katanyuwong, K. and Sriudomkajorn, S. and Wilmshurst, J. and Segel, R. and Gilboa, T. and Tzadok, M. and Fattal-Valevski, T. and Papathanasopoulos, P. and Papavasiliou, A.S.P. and Giannakodimos, S. and Gatzonis, S. and Pavlou, E. and Tzoufi, M. and Vergeer, A.M.H. and Dhooghe, M. and Verhelst, H. and Roelens, F. and Nassogne, M.C.N. and Defresne, P. and Waele, L.D.W. and Leroy, P. and Demonceau, N. and Legros, B. and Bogaert, P.V.B. and Ceulemans, B. and Dom, L. and Castelnau, P. and Martin, A.D.S. and Riquet, A. and Milh, M. and Cances, C. and Pedespan, J.-M. and Ville, D. and Roubertie, A. and Auvin, S. and Berquin, P. and Richelme, C. and Allaire, C. and Gueden, S. and Tich, S.N.T. and Godet, B. and da Silva Oliveira Monteiro, J.P. and de Oliveira Ferreira Leao, M.J.S. and Planas, J.C.P. and Bermejo, A.M.B. and Dura, P.S.D. and Aparicio, S.R.A. and Gonzalez, M.J.M. and Pison, J.L.P. and Barca, M.O.B. and Laso, E.L.L. and Luengo, O.A.L. and Rodriguez, F.J.A. and Dieguez, I.M.D. and Salas, A.C.S. and Carrera, I.M.C. and Salcedo, E.M.S. and Petri, M.E.Y. and Candela, R.C.C. and da Conceicao Carrilho, I. and Vieira, J.P.V. and da Silva Oliveira Monteiro, J.P. and de Oliveira Ferreira Leao, M.J.S. and Luis, C.S.M.R. and Mendonca, C.P.M. and Endziniene, M. and Strautmanis, J. and Talvik, I. and Canevini, M.P.C. and Gambardella, A. and Pruna, D. and Buono, S. and Fontana, E. and Bernardina, B.D.B. and Burloiu, C. and Cosma, I.S.B. and Vintan, M.A.V. and Popescu, L. and Zitterbart, K. and Payerova, J. and Bratsky, L. and Zilinska, Z. and Sedlmayr, U.G. and Baumann, M. and Haberlandt, E. and Rostasy, K. and Pataraia, E. and Elmslie, F. and Johnston, C.A.J. and Crawford, P. and Uldall, P. and Uvebrant, P. and Rask, O. and Bjoernvold, M. and Brodtkorb, E. and Sloerdahl, A. and Solhoff, R. and Jaatun, M.S.G. and Mandera, M. and Radzikowska, E.J.R. and Wysocki, M. and Fischereder, M. and Kurlemann, G. and Wilken, B. and K-ruel, A.W.K. and Budde, K. and Marquard, K. and Knuf, M. and Hahn, A. and Hartmann, H. and Merkenschlager, A. and Trollmann, R. and Investigators, TOSCA Consortium TOSCA},
	year = {2020},
	note = {Publisher: Frontiers Media S.A.},
	keywords = {Article, adolescent, adult, aged, career, caregiver, child, disease burden, educational status, employment, family life, female, human, informed consent, major clinical study, male, patient care, personal experience, psychological well-being, quality of life, questionnaire, social psychology, social support, tuberous sclerosis, unemployment, validation process},
}

@article{wu_carotenoid_2020,
	title = {Carotenoid {Intake} and {Circulating} {Carotenoids} {Are} {Inversely} {Associated} with the {Risk} of {Bladder} {Cancer}: {A} {Dose}-{Response} {Meta}-analysis},
	volume = {11},
	issn = {2156-5376},
	shorttitle = {Carotenoid {Intake} and {Circulating} {Carotenoids} {Are} {Inversely} {Associated} with the {Risk} of {Bladder} {Cancer}},
	doi = {10.1093/advances/nmz120},
	abstract = {Some evidence indicates that carotenoids may reduce the risk of bladder cancer (BC), but the association is unclear. We conducted a systematic review and meta-analysis of case-control and cohort studies investigating the relation between carotenoid intake or circulating carotenoid concentrations and BC risk in men and women. All relevant epidemiologic studies were identified by a search of PubMed and Scopus databases, and the Cochrane Library from inception to April 2019 with no restrictions. A random-effects model was used to calculate pooled RRs and their 95\% CIs across studies for high compared with low categories of intake or circulating concentrations. We also performed a dose-response meta-analysis using the Greenland and Longnecker method and random-effects models. A total of 22 studies involving 516,740 adults were included in the meta-analysis. The pooled RRs of BC for the highest compared with the lowest category of carotenoid intake and circulating carotenoid concentrations were 0.88 (95\% CI: 0.76, 1.03) and 0.36 (95\% CI: 0.12, 1.07), respectively. The pooled RR of BC for the highest compared with lowest circulating lutein and zeaxanthin concentrations was 0.53 (95\% CI: 0.33, 0.84). Dose-response analysis showed that BC risk decreased by 42\% for every 1 mg increase in daily dietary β-cryptoxanthin intake (RR: 0.58; 95\% CI: 0.36, 0.94); by 76\% for every 1 μmol/L increase in circulating concentration of α-carotene (RR: 0.24; 95\% CI: 0.08, 0.67); by 27\% for every 1 μmol/L increase in circulating concentration of β-carotene (RR: 0.73; 95\% CI: 0.57, 0.94); and by 56\% for every 1 μmol/L increase in circulating concentrations of lutein and zeaxanthin (RR: 0.44; 95\% CI: 0.28, 0.67). Dietary β-cryptoxanthin intake and circulating concentrations of α-carotene, β-carotene, and lutein and zeaxanthin were inversely associated with BC risk. The protocol was registered at PROSPERO as CRD42019133240.},
	language = {eng},
	number = {3},
	journal = {Advances in Nutrition (Bethesda, Md.)},
	author = {Wu, Shenghui and Liu, Yanning and Michalek, Joel E. and Mesa, Ruben A. and Parma, Dorothy Long and Rodriguez, Ronald and Mansour, Ahmed M. and Svatek, Robert and Tucker, Thomas C. and Ramirez, Amelie G.},
	month = may,
	year = {2020},
	pmid = {31800007},
	pmcid = {PMC7231589},
	keywords = {Adult, Carotenoids, Female, Humans, Lutein, Male, Urinary Bladder Neoplasms, Zeaxanthins, beta Carotene, bladder cancer, blood, carotenoids, diet, lutein, lycopene, zeaxanthin, α-carotene, β-carotene, β-cryptoxanthin},
	pages = {630--643},
}

Paper  doi  bibtex   

@article{brakoulias_rates_2020,
	title = {The rates of co-occurring behavioural addictions in treatment-seeking individuals with obsessive-compulsive disorder: a preliminary report},
	volume = {24},
	issn = {13651501},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078016820&doi=10.1080%2f13651501.2019.1711424&partnerID=40&md5=f7662be6edcfacc238a638b465092af8},
	doi = {10.1080/13651501.2019.1711424},
	language = {English},
	number = {2},
	journal = {International Journal of Psychiatry in Clinical Practice},
	author = {Brakoulias, V. and Starcevic, V. and Albert, U. and Arumugham, S.S. and Bailey, B.E. and Belloch, A. and Borda, T. and Dell’Osso, L. and Elias, J.A. and Falkenstein, M.J. and Ferrao, Y.A. and Fontenelle, L.F. and Jelinek, L. and Kay, B. and Lochner, C. and Maina, G. and Marazziti, D. and Matsunaga, H. and Miguel, E.C. and Morgado, P. and Pasquini, M. and Perez-Rivera, R. and Potluri, S. and Reddy, J.Y.C. and Riemann, B.C. and do Rosario, M.C. and Shavitt, R.G. and Stein, D.J. and Viswasam, K. and Fineberg, N.A.},
	year = {2020},
	note = {Publisher: Taylor and Francis Ltd},
	keywords = {Addictive, Adolescent, Adult, Argentina, Article, Australia, Behavior, Brazil, Comorbidity, Female, Gambling, Germany, Humans, India, Internet, Internet Addiction Disorder, Italy, Japan, Male, Mexico, Middle Aged, Obsessive-Compulsive Disorder, Portugal, Sexual Behavior, South Africa, Spain, United Kingdom, United States, Video Games, Young Adult, addiction, adolescent, adult, behavioral addiction, clinical trial, comorbidity, compulsive buying, female, gambling, game addiction, help seeking behavior, human, internet addiction, major clinical study, male, middle aged, multicenter study, obsessive compulsive disorder, pathological gambling, priority journal, sexual behavior, video game, young adult},
	pages = {173--175},
}

Paper  doi  bibtex   

@article{lourens_acute_2020,
	title = {Acute pain assessment and management in the prehospital setting, in the {Western} {Cape}, {South} {Africa}: {A} knowledge, attitudes and practices survey},
	volume = {20},
	issn = {1471227X},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084107654&doi=10.1186%2fs12873-020-00315-0&partnerID=40&md5=6a9e1ed0ddf7e6a805a5a2f423b829e2},
	doi = {10.1186/s12873-020-00315-0},
	language = {English},
	number = {1},
	journal = {BMC Emergency Medicine},
	author = {Lourens, A. and Hodkinson, P. and Parker, R.},
	year = {2020},
	note = {Publisher: BioMed Central Ltd.},
	keywords = {Acute Pain, Adult, Article, Attitudes, Cross-Sectional Studies, Emergency Medical Technicians, Female, Health Knowledge, Humans, Internet, Male, Pain Measurement, Practice, Professional Competence, South Africa, Surveys and Questionnaires, adult, age, alcohol consumption, analgesia, analgesic agent, attitude, attitude to health, case study, clinical practice, controlled study, cross-sectional study, descriptive research, drug dependence, emergency care, female, gender, government, health personnel attitude, human, job experience, ketamine, male, medical education, middle aged, morphine, nitrous oxide plus oxygen, pain, pain assessment, pain measurement, patient-reported outcome, professional competence, questionnaire, rescue personnel, scoring system, validation study, young adult},
}

Website  abstract   bibtex   

@article{
 title = {Intrinsic functional and structural connectivity of emotion regulation networks in obsessive-compulsive disorder},
 type = {article},
 year = {2019},
 identifiers = {[object Object]},
 keywords = {Adult,Amygdala,Case-Control Studies,Emotions,Female,Humans,Magnetic Resonance Imaging,Male,Obsessive-Compulsive Disorder},
 pages = {110-120},
 volume = {36},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/30253000},
 id = {da7dfdeb-3ba9-322b-bbdc-f9d9b860019d},
 created = {2020-09-17T09:27:48.121Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:48.121Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {Despite emotion regulation being altered in patients with obsessive-compulsive disorder (OCD), no studies have investigated its relation to multimodal amygdala connectivity. We compared corticolimbic functional and structural connectivity between OCD patients and healthy controls (HCs), and correlated this with the dispositional use of emotion regulation strategies and with OCD severity. OCD patients (n = 73) and HCs (n = 42) were assessed for suppression and reappraisal strategies using the Emotion Regulation Questionnaire (ERQ) and for OCD severity using the Yale-Brown Obsessive-Compulsive Scale. Resting-state functional magnetic resonance imaging (rs-fMRI) connectivity maps were generated using subject-specific left amygdala (LA) and right amygdala (RA) masks. We identified between-group differences in amygdala whole-brain connectivity, and evaluated the moderating effect of ERQ strategies. Significant regions and amygdala seeds were used as targets in probabilistic tractography analysis. Patients scored higher in suppression and lower in reappraisal. We observed higher rs-fMRI RA-right postcentral gyrus (PCG) connectivity in HC, and in patients this was correlated with symptom severity. Reappraisal scores were associated with higher negative LA-left insula connectivity in HC, and suppression scores were negatively associated with LA-precuneus and angular gyri connectivity in OCD. Structurally, patients showed higher mean diffusivity in tracts connecting the amygdala with the other targets. RA-PCG connectivity is diminished in patients, while disrupted emotion regulation is related to altered amygdala connectivity with the insula and posterior brain regions. Our results are the first showing, from a multimodal perspective, the association between amygdala connectivity and specific emotional processing domains, emphasizing the importance of amygdala connectivity in OCD pathophysiology.},
 bibtype = {article},
 author = {Picó-Pérez, Maria and Ipser, Jonathan and Taylor, Paul and Alonso, Pino and López-Solà, Clara and Real, Eva and Segalàs, Cinto and Roos, Annerine and Menchón, José M and Stein, Dan J and Soriano-Mas, Carles},
 journal = {Depression and Anxiety},
 number = {2}
}

Paper  doi  abstract   bibtex   

@article{costa_impact_2019,
	title = {The impact of intimate partner violence on forgone healthcare: a population-based, multicentre {European} study},
	volume = {29},
	issn = {1464-360X},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30169658},
	doi = {10.1093/eurpub/cky167},
	abstract = {BACKGROUND: To examine the relationship between forgone healthcare and involvement in intimate partner violence (IPV) as victims, perpetrators or both. METHODS: This cross-sectional multicentre study assessed community non-institutionalized residents (n = 3496, aged 18-64) randomly selected from six European cities: Athens, Budapest, London, Östersund, Porto, Stuttgart. A common questionnaire was used, including self-reports of IPV and forgone healthcare ('Have you been in need of a certain care service in the past year, but did not seek any help?'). Odds ratios (ORs), 95\% confidence intervals (CIs) were computed fitting logistic regression models adjusted for city, chronic disease, self-assessed health status and financial strain. RESULTS: Participants experiencing past year IPV (vs. no violence) reported more often to forgone healthcare (n = 3279, 18.6\% vs. 15.3\%, P = 0.016). IPV experienced as both a victim and perpetrator was associated with forgone healthcare (adjusted OR, 95\%CI: 1.32, 1.02-1.70). CONCLUSION: IPV was associated with forgone healthcare, particularly for those experiencing violence as both victims and perpetrators. Results suggest that preventing IPV among adults may improve timely healthcare uptake.},
	language = {eng},
	number = {2},
	journal = {European journal of public health},
	author = {Costa, Diogo and Hatzidimitriadou, Eleni and Ioannidi-Kapolo, Elli and Lindert, Jutta and Soares, Joaquim and Sundin, Örjan and Toth, Olga and Barros, Henrique},
	month = apr,
	year = {2019},
	keywords = {Adolescent, Adult, Cross-Sectional Studies, Europe, Female, Health Status, Humans, Intimate Partner Violence/*statistics \& numerical data, Male, Middle Aged, Patient Acceptance of Health Care/*statistics \& numerical data, Socioeconomic Factors, Spouse Abuse/statistics \& numerical data, Young Adult},
	pages = {359--364},
}

Paper  doi  abstract   bibtex   

@article{widerstrom_aspects_2019,
	title = {Aspects influencing clinical reasoning and decision-making when matching treatment to patients with low back pain in primary healthcare},
	volume = {41},
	issn = {2468-7812},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30818071},
	doi = {10.1016/j.msksp.2019.02.003},
	abstract = {BACKGROUND: It is unclear how physiotherapists match treatment to patients with low-back pain (LBP) in primary healthcare. A further exploration of physiotherapists' perspective of matching treatments to the individual patient in this setting is needed. OBJECTIVE: The aim of this study was to explore and describe aspects influencing physiotherapists' clinical reasoning in the decision-making on individualized treatment of LBP in primary healthcare. DESIGN: This was an explorative study using qualitative content analysis. METHOD: Fifteen semi-structured individual interviews were conducted with physiotherapists, men and women, experienced and novice, working in primary healthcare settings in one sparsely populated region and in one larger city in Sweden. FINDINGS: Two overarching themes were identified influencing decision-making for individualized treatment of LBP: 1) Matching requires differentiation and adaptation, with categories describing specific patient characteristics, assessment findings and treatment adaptations (classification of pain and bodily findings; patient physical capacity and emotions; patient awareness and motivation; treatment combinations and atypical treatment rationales): and 2) The tension between trust and barriers; with categories describing aspects of physiotherapists' convictions, constraints and working environment (confidence in treatments and oneself; physiotherapists' terms overrule patients' preferences; personal constraints and workplace approach and priorities). CONCLUSION: This study describes aspects of the patients, the physiotherapists and their workplaces that influence decisions for individualized treatment of LBP. The findings underpin the need for clinician self-reflection, initiatives for skilled clinical competence and the weight clinician observations carry on the complex treatment selection process which need to be appreciated when implementing evidence-based recommendations in clinical practice.},
	language = {eng},
	journal = {Musculoskeletal science \& practice},
	author = {Widerström, Birgitta and Rasmussen-Barr, Eva and Boström, Carina},
	month = jun,
	year = {2019},
	keywords = {*Attitude of Health Personnel, *Health Knowledge, Attitudes, Practice, *Professional-Patient Relations, Adult, Aged, Aged, 80 and over, Decision Making, Female, Humans, Low Back Pain/*therapy, Male, Middle Aged, Patient Preference/*psychology, Physical Therapists/*psychology, Primary Health Care/*methods, Qualitative Research},
	pages = {6--14},
}

@article {650292,
	title = {Ovarian Cancer: Prevalence in Incidental Simple Adnexal Cysts Initially Identified in CT Examinations of the Abdomen and Pelvis},
	journal = {Radiology},
	volume = {286},
	number = {1},
	year = {2018},
	month = {2018 01},
	pages = {196-204},
	abstract = {Purpose To evaluate the rate of malignancy in incidentally detected simple adnexal cysts at computed tomography (CT) to determine if simple-appearing cysts require follow-up. Materials and Methods In this HIPAA-compliant, institutional review board-approved retrospective cohort study, an institutional database was searched for abdominal and pelvic CT studies performed between June 2003 and December 2010 in women reported to have adnexal cysts. Adnexal cyst characterization was determined by prospective report description as well as image review by a research fellow and by a fellowship-trained abdominal radiologist for examinations with disagreement between the original report and the research fellow{\textquoteright}s assessment. Patients with known ovarian cysts or ovarian cancer at time of the index CT examination were excluded. Clinical outcome was assessed by using follow-up imaging studies, medical records, and the state cancer registry. Benign outcome was determined by benign findings at surgery, a decrease in size or resolution of a simple-appearing cyst at follow-up imaging, or stability of the cyst for at least 1 year. Descriptive statistics and 95\% confidence intervals (CIs) were calculated. Results Among 42 111 women who underwent abdominal and pelvic CT examinations in the study period, 2763 (6.6\%; 95\% CI: 6.3\%, 6.8\%) (mean age, 48.1 years {\textpm} 18.1; range, 15-102 years) had a newly detected finding of ovarian cyst described in the body or impression section of the report. Median cyst size was 3.1 cm (range, 0.8-20.0 cm). Eighteen (0.7\%; 95\% CI: 0.4\%, 1.0\%) of 2763 patients were found to have ovarian cancer after an average follow-up of 5.1 years {\textpm} 3.8 (range, 0-12.8 years). None (95\% CI: 0\%, 0.4\%) of 1031 women with simple-appearing cysts were given a diagnosis of ovarian cancer. This included none (95\% CI: 0\%, 0.4\%) of 904 women with simple-appearing cysts with an adequate reference standard for benign outcome. Conclusion The prevalence of previously unknown adnexal cysts at CT was 6.6\%, with an ovarian cancer rate of 0.7\% (95\% CI: 0.4\%, 1.0\%). All simple-appearing cysts were benign (95\% CI: 99.6\%, 100\%).  RSNA, 2017 Online supplemental material is available for this article.},
	keywords = {Abdomen, Adult, Aged, Female, Humans, Incidental Findings, Middle Aged, Ovarian Cysts, Ovarian Neoplasms, Pelvis, Retrospective Studies, Tomography, X-Ray Computed},
	issn = {1527-1315},
	doi = {10.1148/radiol.2017162139},
	author = {Johannes Boos and Olga R Brook and Jieming Fang and Alexander Brook and Levine, Deborah}
}

@article{lally_remission_2017-1,
	title = {Remission and recovery from first-episode psychosis in adults: systematic review and meta-analysis of long-term outcome studies},
	volume = {211},
	issn = {1472-1465},
	shorttitle = {Remission and recovery from first-episode psychosis in adults},
	doi = {10.1192/bjp.bp.117.201475},
	abstract = {BackgroundRemission and recovery rates for people with first-episode psychosis (FEP) remain uncertain.AimsTo assess pooled prevalence rates of remission and recovery in FEP and to investigate potential moderators.MethodWe conducted a systematic review and meta-analysis to assess pooled prevalence rates of remission and recovery in FEP in longitudinal studies with more than 1 year of follow-up data, and conducted meta-regression analyses to investigate potential moderators.ResultsSeventy-nine studies were included representing 19072 patients with FEP. The pooled rate of remission among 12301 individuals with FEP was 58\% (60 studies, mean follow-up 5.5 years). Higher remission rates were moderated by studies from more recent years. The pooled prevalence of recovery among 9642 individuals with FEP was 38\% (35 studies, mean follow-up 7.2 years). Recovery rates were higher in North America than in other regions.ConclusionsRemission and recovery rates in FEP may be more favourable than previously thought. We observed stability of recovery rates after the first 2 years, suggesting that a progressive deteriorating course of illness is not typical. Although remission rates have improved over time recovery rates have not, raising questions about the effectiveness of services in achieving improved recovery.},
	language = {eng},
	number = {6},
	journal = {The British Journal of Psychiatry: The Journal of Mental Science},
	author = {Lally, John and Ajnakina, Olesya and Stubbs, Brendon and Cullinane, Michael and Murphy, Kieran C. and Gaughran, Fiona and Murray, Robin M.},
	month = dec,
	year = {2017},
	pmid = {28982659},
	keywords = {Adult, Humans, Outcome Assessment (Health Care), Psychotic Disorders},
	pages = {350--358}
}

Paper  doi  abstract   bibtex   

@article{meneses_fernandez_using_2017,
	title = {Using communication and visualization technologies with senior citizens to facilitate cultural access and self-improvement},
	volume = {66},
	issn = {07475632},
	url = {https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84991489830&doi=10.1016%2fj.chb.2016.10.001&partnerID=40&md5=28ad769cb901aea58030895ba49715d2},
	doi = {10.1016/j.chb.2016.10.001},
	abstract = {This paper presents the results of research that explores the social impacts and benefits of using digital visualization technologies, which include Augmented Reality (AR), Virtual Reality (VR) and Quick Response codes (QR codes). The target group for this study was senior citizens in an adult day care centre. This group was selected for two reasons: firstly, for belonging to a generation that has not grown up surrounded by digital technologies; and secondly, for therefore being at a disadvantage when it comes to adopting and using modern day information and communication technologies. Research was focused on the potential benefits of digital technologies and also on how senior citizens responded towards them, in particular how they felt these technologies were improving their social and personal well-being. Digital technologies were introduced into the day-to-day lives of senior citizens, providing them with a variety of alternative ways to access social media, communication tools or cultural content. Using digital technologies, they were also asked to perform activities related to their own personal and social well-being. © 2016 Elsevier Ltd},
	language = {English},
	journal = {Computers in Human Behavior},
	author = {Meneses Fernández, M.D. and Santana Hernández, J.D. and Martín Gutiérrez, J. and Henríquez Escuela, M.R. and Rodríguez Fino, E.},
	year = {2017},
	keywords = {Augmented reality, Communication tools, Digital technologies, Digital visualization, Economic and social effects, Information and Communication Technologies, Mass media, Senior citizens, Social well-being, Virtual reality, Visualization, Visualization technologies, adult, adult day care, human, human experiment, mass medium, social media, virtual reality, wellbeing},
	pages = {329--344}
}

Paper  abstract   bibtex   

@misc{baker_s.c._systematic_2017,
	title = {Systematic {Review} of {Interventions} to {Reduce} {Psychiatric} {Morbidity} in {Parents} and {Children} {After} {PICU} {Admissions}},
	url = {http://journals.lww.com/pccmjournal},
	abstract = {OBJECTIVE:: To describe and evaluate interventions aimed at reducing psychiatric morbidity in parents and children discharged from PICU. DATA SOURCES:: A systematic review of the literature was undertaken, searching EMBASE, PSYCHinfo, MEDLINE, and CINAHL. Experts in the field were contacted to identify unpublished studies. STUDY SELECTION:: Exclusion criteria: Studies with participants above age 18 or drawn from a neonatal ICU, studies not in English, and those not measuring psychopathology. DATA EXTRACTION:: Seven hundred fifty-three articles initially identified were hand searched which identified three studies, with a further three studies found by contacting experts in the field. Of these, three were randomized controlled trials and three feasibility studies. DATA SYNTHESIS:: The interventions primarily targeted parents (particularly mothers), with the aim of reducing psychopathology especially posttraumatic stress disorder. Findings from these few studies demonstrated that interventions can lead to a reduction in parent and child psychopathology. Key ingredients of these interventions included psychoeducation, parent support after discharge, offering intervention to those families at high risk of developing psychopathology as identified by screening at the point of discharge, follow-up of all families with the aim of case finding, and specific interventions to target posttraumatic stress disorder symptoms. CONCLUSIONS:: Intervention studies are few but do lead to reductions in parent and child psychopathology. There is sufficient information to suggest some of these interventions could be supported and further evaluated. Copyright ©2017The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies},
	journal = {Pediatric Critical Care Medicine},
	author = {{Baker S.C.} and {Gledhill J.A.}},
	year = {2017},
	keywords = {*morbidity, *psychiatric intensive care unit, Child, Cinahl, Embase, Medline, Neonatal intensive care unit, PsycINFO, adult, case finding, controlled study, family study, feasibility study, female, follow up, human, intervention study, mental disease, mother, newborn, posttraumatic stress disorder, psychoeducation, screening, systematic review, young adult}
}

@article{koyama_serum_2017,
	title = {Serum ferritin level is a prognostic marker in patients with peripheral {T}-cell lymphoma},
	volume = {39},
	issn = {1751-553X},
	doi = {10.1111/ijlh.12592},
	abstract = {INTRODUCTION

The prognostic value of serum ferritin level in patients with peripheral T-cell lymphoma (PTCL) remains unknown.


METHODS

We retrospectively analyzed clinical data from 78 consecutive patients with newly diagnosed PTCL that were treated with anthracycline-containing regimens between 1998 and 2011.


RESULTS

The patients consisted of 50 males and 28 females with a median age of 64 years (range, 16-83 years). The subtypes of PTCL were 39 PTCL, not otherwise specified and 39 angioimmunoblastic T-cell lymphoma (AITL). The median observation period for the surviving patients was 50 months. The overall survival (OS) was poorer in patients with serum ferritin level above the upper normal limit (n = 28), compared with patients with serum ferritin level within normal range (n = 50; 4-year OS: 23\% vs. 72\%; P {\textless} 0.001). In the multivariate analysis, poor performance status (P = 0.006) and elevated serum ferritin level (P = 0.018) were independent risk factors for poor OS.


CONCLUSION

Serum ferritin level is a useful prognostic marker for PTCL.},
	number = {1},
	journal = {International journal of laboratory hematology},
	author = {Koyama, S and Fujisawa, S and Watanabe, R and Itabashi, M and Ishibashi, D and Ishii, Y and Hattori, Y and Nakajima, Y and Motohashi, K and Takasaki, H and Kawasaki, R and Hashimoto, C and Yamazaki, E and Koharazawa, H and Takemura, S and Tomita, N and Sakai, R and Motomura, S and Nakajima, H},
	month = feb,
	year = {2017},
	pmid = {27885817},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Anthracyclines, Disease-Free Survival, Female, Ferritins, Humans, Lymphoma, T-Cell, Peripheral, Male, Middle Aged, Retrospective Studies, Survival Rate},
	pages = {112--117}
}

Paper  abstract   bibtex   

@article{correa-selm_use_2017,
	title = {Use of {Biologics} in {Private} {Practice}: {Nine} {Years} of {Lessons} and {Learning}},
	volume = {16},
	copyright = {All rights reserved},
	issn = {1545-9616 (Print) 1545-9616 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/28301616},
	abstract = {{\textless}p{\textgreater}Over a decade ago, the FDA approved biologics for psoriasis, which changed how the disease is treated and, in most cases, has a significant positive impact on the lives of patients. Side effects primarily identified during the investigational and research phase led to the development of specific guidelines for treatment. The treatment guidelines have been amended to incorporate better understandings of side-effects over the years that the disease has been treated. In this study, we focused on a chart review that included assessing the current guidelines and their alignment with modern patient management and the recent side effects presented. This life-cycle evaluation included over 100 patients, management of their treatment, laboratory abnormalities, criteria for choosing or changing to a different biologic, and the effects of the treatments management throughout the years. The review identified some recommended changes in the application and treatment of psoriasis with biologics. To further evidence our findings, we hope to expand this study to a larger scale with more patients.{\textless}/p{\textgreater} {\textless}p{\textgreater}{\textless}em{\textgreater}J Drugs Dermatol. 2017;16(3):215-217.{\textless}/em{\textgreater}{\textless}/p{\textgreater}.},
	number = {3},
	journal = {J Drugs Dermatol},
	author = {Correa-Selm, L. M. and Alamgir, M. and Rao, B. K.},
	month = mar,
	year = {2017},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Biological Products/administration \& dosage/adverse effects/*therapeutic use, Child, Female, Humans, Male, Middle Aged, Practice Guidelines as Topic, Private Practice/*trends, Psoriasis/blood/*drug therapy, Quality of Life, Retrospective Studies, Severity of Illness Index, Young Adult},
	pages = {215--217},
}

@article{engels_cancer-attributable_2017,
	title = {Cancer-{Attributable} {Mortality} {Among} {People} {With} {Treated} {Human} {Immunodeficiency} {Virus} {Infection} in {North} {America}},
	volume = {65},
	issn = {1537-6591},
	doi = {10.1093/cid/cix392},
	abstract = {Background: Cancer remains an important cause of morbidity and mortality in people with human immunodeficiency virus (PWHIV) on effective antiretroviral therapy (ART). Estimates of cancer-attributable mortality can inform public health efforts.
Methods: We evaluated 46956 PWHIV receiving ART in North American HIV cohorts (1995-2009). Using information on incident cancers and deaths, we calculated population-attributable fractions (PAFs), estimating the proportion of deaths due to cancer. Calculations were based on proportional hazards models adjusted for age, sex, race, HIV risk group, calendar year, cohort, CD4 count, and viral load.
Results: There were 1997 incident cancers and 8956 deaths during 267145 person-years of follow-up, and 11.9\% of decedents had a prior cancer. An estimated 9.8\% of deaths were attributable to cancer (cancer-attributable mortality rate 327 per 100000 person-years). PAFs were 2.6\% for AIDS-defining cancers (ADCs, including non-Hodgkin lymphoma, 2.0\% of deaths) and 7.1\% for non-AIDS-defining cancers (NADCs: lung cancer, 2.3\%; liver cancer, 0.9\%). PAFs for NADCs were higher in males and increased strongly with age, reaching 12.5\% in PWHIV aged 55+ years. Mortality rates attributable to ADCs and NADCs were highest for PWHIV with CD4 counts {\textless}100 cells/mm3. PAFs for NADCs increased during 1995-2009, reaching 10.1\% in 2006-2009.
Conclusions: Approximately 10\% of deaths in PWHIV prescribed ART during 1995-2009 were attributable to cancer, but this fraction increased over time. A large proportion of cancer-attributable deaths were associated with non-Hodgkin lymphoma, lung cancer, and liver cancer. Deaths due to NADCs will likely grow in importance as AIDS mortality declines and PWHIV age.},
	language = {eng},
	number = {4},
	journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
	author = {Engels, Eric A. and Yanik, Elizabeth L. and Wheeler, Willian and Gill, M. John and Shiels, Meredith S. and Dubrow, Robert and Althoff, Keri N. and Silverberg, Michael J. and Brooks, John T. and Kitahata, Mari M. and Goedert, James J. and Grover, Surbhi and Mayor, Angel M. and Moore, Richard D. and Park, Lesley S. and Rachlis, Anita and Sigel, Keith and Sterling, Timothy R. and Thorne, Jennifer E. and Pfeiffer, Ruth M. and {North American AIDS Cohort Collaboration on Research and
                    Design of the International Epidemiologic Databases to Evaluate AIDS} and {North American AIDS Cohort Collaboration on Research and Design
                    of the International Epidemiologic Databases to Evaluate AIDS}},
	month = aug,
	year = {2017},
	pmid = {29017269},
	pmcid = {PMC5849088},
	keywords = {AIDS, Adolescent, Adult, CD4 Lymphocyte Count, Female, HIV, HIV Infections, Humans, Male, Middle Aged, Neoplasms, North America, Proportional Hazards Models, Retrospective Studies, Viral Load, Young Adult, aging, cancer, mortality},
	pages = {636--643},
}

@article{pascual_bloodstream_2016,
	title = {Bloodstream infections caused by {Escherichia} coli producing {AmpC} β-lactamases: epidemiology and clinical features},
	volume = {35},
	issn = {1435-4373},
	shorttitle = {Bloodstream infections caused by {Escherichia} coli producing {AmpC} β-lactamases},
	doi = {10.1007/s10096-016-2752-3},
	abstract = {The aim of the study was to investigate the epidemiology and clinical features of bloodstream infections due to Escherichia coli producing AmpC β-lactamases (AmpC-Ec-BSI). In a multi-centre case-control study, all third-generation-cephalosporin-resistant Escherichia coli BSI (3GC-Ec-BSI) isolates were analysed. Acquired bla AmpC (bla ac-AmpC) detection was done by polymerase chain reaction (PCR) and sequencing. Chromosomal bla AmpC (bla c-AmpC) expression was quantified by real-time PCR. Cases were patients with AmpC-Ec-BSI. Controls were patients with cephalosporin-susceptible E. coli BSI, matched 1:1 by sex and age. Demographics, comorbidities, intrinsic and extrinsic risk factors for antimicrobial resistance, clinical presentation and outcomes were investigated. Among 841 E. coli BSI, 17 were caused by AmpC-Ec (2 \%). Eleven isolates (58.8 \%) had bla ac-AmpC and six were bla c-AmpC overproducers. The mean age of cases was 66.2 years and 71 \% were men. Cases were more frequently healthcare-related (82 vs. 52 \% controls, p {\textless} 0.05) and presented more intrinsic and extrinsic risk factors. At least one risk factor was present in 94.1 \% of cases vs. 41.7 \% of controls (p = 0.002). Severity and length of stay (LOS) were higher among cases (mean Pitt Score 2.6 vs. 0.38 in controls, p = 0.03; LOS 17.5 days vs. 6 in controls, p = 0.02). Inappropriate empirical therapy (IET) was administered to 70.6 \% of cases and 23.5 \% of controls (p {\textless} 0.003). No differences were found in terms of cure rate at the 14th day and mortality. Bloodstream infections due to AmpC-Ec (mostly plasmid-mediated) are infrequent in our area. AmpC-Ec-BSI affects mainly patients with intrinsic risk factors and those with previous antibiotic exposure. A high proportion received IET.},
	language = {eng},
	number = {12},
	journal = {European Journal of Clinical Microbiology \& Infectious Diseases: Official Publication of the European Society of Clinical Microbiology},
	author = {Pascual, V. and Alonso, N. and Simó, M. and Ortiz, G. and Garcia, M. C. and Xercavins, M. and Rivera, A. and Morera, M. A. and Miró, E. and Espejo, E. and Navarro, F. and Gurguí, M. and Pérez, J. and Rodríguez-Carballeira, M. and Garau, J. and Calbo, E.},
	year = {2016},
	pmid = {27549108},
	keywords = {Adult, Age Distribution, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacteremia, Bacterial Proteins, Case-Control Studies, DNA, Bacterial, Escherichia coli, Escherichia coli Infections, Female, Humans, Length of Stay, Male, Middle Aged, Polymerase Chain Reaction, Risk Factors, Sequence Analysis, DNA, Severity of Illness Index, Treatment Outcome, beta-Lactamases},
	pages = {1997--2003},
}

@article{silverberg_cumulative_2015,
	title = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}: {A} {Cohort} {Study}},
	volume = {163},
	issn = {1539-3704},
	shorttitle = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}},
	doi = {10.7326/M14-2768},
	abstract = {BACKGROUND: Cancer is increasingly common among persons with HIV.
OBJECTIVE: To examine calendar trends in cumulative cancer incidence and hazard rate by HIV status.
DESIGN: Cohort study.
SETTING: North American AIDS Cohort Collaboration on Research and Design during 1996 to 2009.
PARTICIPANTS: 86 620 persons with HIV and 196 987 uninfected adults.
MEASUREMENTS: Cancer type-specific cumulative incidence by age 75 years and calendar trends in cumulative incidence and hazard rates, each by HIV status.
RESULTS: Cumulative incidences of cancer by age 75 years for persons with and without HIV, respectively, were as follows: Kaposi sarcoma, 4.4\% and 0.01\%; non-Hodgkin lymphoma, 4.5\% and 0.7\%; lung cancer, 3.4\% and 2.8\%; anal cancer, 1.5\% and 0.05\%; colorectal cancer, 1.0\% and 1.5\%; liver cancer, 1.1\% and 0.4\%; Hodgkin lymphoma, 0.9\% and 0.09\%; melanoma, 0.5\% and 0.6\%; and oral cavity/pharyngeal cancer, 0.8\% and 0.8\%. Among persons with HIV, calendar trends in cumulative incidence and hazard rate decreased for Kaposi sarcoma and non-Hodgkin lymphoma. For anal, colorectal, and liver cancer, increasing cumulative incidence, but not hazard rate trends, were due to the decreasing mortality rate trend (-9\% per year), allowing greater opportunity to be diagnosed. Despite decreasing hazard rate trends for lung cancer, Hodgkin lymphoma, and melanoma, cumulative incidence trends were not seen because of the compensating effect of the declining mortality rate.
LIMITATION: Secular trends in screening, smoking, and viral co-infections were not evaluated.
CONCLUSION: Cumulative cancer incidence by age 75 years, approximating lifetime risk in persons with HIV, may have clinical utility in this population. The high cumulative incidences by age 75 years for Kaposi sarcoma, non-Hodgkin lymphoma, and lung cancer support early and sustained antiretroviral therapy and smoking cessation.},
	language = {eng},
	number = {7},
	journal = {Annals of Internal Medicine},
	author = {Silverberg, Michael J. and Lau, Bryan and Achenbach, Chad J. and Jing, Yuezhou and Althoff, Keri N. and D'Souza, Gypsyamber and Engels, Eric A. and Hessol, Nancy A. and Brooks, John T. and Burchell, Ann N. and Gill, M. John and Goedert, James J. and Hogg, Robert and Horberg, Michael A. and Kirk, Gregory D. and Kitahata, Mari M. and Korthuis, Philip T. and Mathews, William C. and Mayor, Angel and Modur, Sharada P. and Napravnik, Sonia and Novak, Richard M. and Patel, Pragna and Rachlis, Anita R. and Sterling, Timothy R. and Willig, James H. and Justice, Amy C. and Moore, Richard D. and Dubrow, Robert and {North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS}},
	month = oct,
	year = {2015},
	pmid = {26436616},
	pmcid = {PMC4711936},
	keywords = {Adult, Age Distribution, Aged, Anus Neoplasms, Cohort Studies, Colorectal Neoplasms, Comorbidity, Female, HIV Infections, Humans, Incidence, Liver Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Male, Middle Aged, Neoplasms, North America, Proportional Hazards Models, Sarcoma, Kaposi},
	pages = {507--518},
}

Paper  doi  abstract   bibtex   

@article{selmouni_acceptability_2015,
	title = {Acceptability of the human papilloma virus vaccine among {Moroccan} parents: a population-based crosssectional study.},
	volume = {21},
	issn = {1020-3397},
	url = {http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=110150320&site=ehost-live},
	doi = {10.26719/2015.21.8.555},
	abstract = {Data about the public's awareness and acceptability of the human papilloma virus (HPV) vaccine are lacking in the Eastern Mediterranean Region. This study aimed to explore parental acceptability of HPV vaccination for their daughters in Morocco. A cross-sectional survey was carried out among mothers and fathers of girls aged 12-15 years at 12 middle schools from 6 regions of Morocco. Despite weak knowledge of genital warts and HPV infection, acceptability of the HPV vaccine was 76.8\% (95\% CI: 73.3-79.9\%) among mothers and 68.9\% (95\% CI: 65.2-72.5\%) among fathers. Only 8.8\% of mothers and 7.0\% of fathers were against administration of the HPV vaccine to their daughters. Predictors of parents' acceptance of the HPV vaccine were living in precarious housing/slums and low household income (for mothers) and living in urban areas (for fathers). These results will be useful for preparing the introduction of the HPV vaccine in health ministry programmes.},
	number = {8},
	journal = {Eastern Mediterranean Health Journal},
	author = {Selmouni, F. and Zidouh, A. and Nejjari, C. and Bekkali, R.},
	month = aug,
	year = {2015},
	note = {Publisher: World Health Organization},
	keywords = {Academic Medical Centers, Adolescence, Adult, Cervix Neoplasms -- Prevention and Control, Confidence Intervals, Cross Sectional Studies, Data Analysis Software, Descriptive Statistics, Female, Funding Source, Human, Interviews, Male, Middle Age, Morocco, Multicenter Studies, Multivariate Analysis, Odds Ratio, Papillomavirus Vaccine -- Classification, Papillomavirus Vaccine -- Therapeutic Use, Parental Attitudes, Surveys},
	pages = {555--563},
}

@article{hippisley-cox_performance_2014,
	title = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice: a validation study},
	volume = {4},
	issn = {2044-6055},
	shorttitle = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice},
	doi = {10.1136/bmjopen-2014-005809},
	abstract = {OBJECTIVES: To validate the performance of a set of risk prediction algorithms developed using the QResearch database, in an independent sample from general practices contributing to the Clinical Research Data Link (CPRD).
SETTING: Prospective open cohort study using practices contributing to the CPRD database and practices contributing to the QResearch database.
PARTICIPANTS: The CPRD validation cohort consisted of 3.3 million patients, aged 25-99 years registered at 357 general practices between 1 Jan 1998 and 31 July 2012. The validation statistics for QResearch were obtained from the original published papers which used a one-third sample of practices separate to those used to derive the score. A cohort from QResearch was used to compare incidence rates and baseline characteristics and consisted of 6.8 million patients from 753 practices registered between 1 Jan 1998 and until 31 July 2013.
OUTCOME MEASURES: Incident events relating to seven different risk prediction scores: QRISK2 (cardiovascular disease); QStroke (ischaemic stroke); QDiabetes (type 2 diabetes); QFracture (osteoporotic fracture and hip fracture); QKidney (moderate and severe kidney failure); QThrombosis (venous thromboembolism); QBleed (intracranial bleed and upper gastrointestinal haemorrhage). Measures of discrimination and calibration were calculated.
RESULTS: Overall, the baseline characteristics of the CPRD and QResearch cohorts were similar though QResearch had higher recording levels for ethnicity and family history. The validation statistics for each of the risk prediction scores were very similar in the CPRD cohort compared with the published results from QResearch validation cohorts. For example, in women, the QDiabetes algorithm explained 50\% of the variation within CPRD compared with 51\% on QResearch and the receiver operator curve value was 0.85 on both databases. The scores were well calibrated in CPRD.
CONCLUSIONS: Each of the algorithms performed practically as well in the external independent CPRD validation cohorts as they had in the original published QResearch validation cohorts.},
	language = {eng},
	number = {8},
	journal = {BMJ open},
	author = {Hippisley-Cox, Julia and Coupland, Carol and Brindle, Peter},
	year = {2014},
	pmid = {25168040},
	pmcid = {PMC4156807},
	keywords = {Adult, Aged, Aged, 80 and over, Algorithms, Calibration, Cardiovascular Diseases, Cprd, Ethnic Groups, Family, Female, General Practice, Hemorrhage, Humans, Kidney Diseases, Male, Middle Aged, Osteoporotic Fractures, Prognosis, Prospective Studies, QResearch, Qrisk2, Risk, Validation, Venous Thromboembolism, diabetes mellitus},
	pages = {e005809}
}

@article{gawri_link_2014,
	title = {Link {N} is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity},
	volume = {32},
	issn = {1554-527X},
	doi = {10.1002/jor.22653},
	abstract = {Presently, there are no established treatments to prevent, stop or even retard back pain arising from disc degeneration. Previous studies have shown that Link N can act as a growth factor and stimulate the synthesis of proteoglycans and collagens, in IVD. However, the sequences in Link N involved in modulating cellular activity are not well understood. To determine if disc cells can proteolytically process Link N, human disc cells were exposed to native Link N over a 48 h period and mass spectrometric analysis revealed that a peptide spanning residues 1-8 was generated in the presence of AF cells but not NP cells. Link N 1-8 significantly induced proteoglycan production in the presence of IL-1β NP and AF cells, confirming that the biological effect is maintained in the first 8 amino acids of the peptide and indicating that the effect is sustained in an inflammatory environment. Thus Link-N 1-8 could be a promising candidate for biologically induced disc repair, and the identification of such a stable specific peptide may facilitate the design of compounds to promote disc repair and provide alternatives to surgical intervention for early stage disc degeneration.},
	language = {eng},
	number = {9},
	journal = {Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society},
	author = {Gawri, Rahul and Ouellet, Jean and Önnerfjord, Patrik and Alkhatib, Bashar and Steffen, Thomas and Heinegård, Dick and Roughley, Peter and Antoniou, John and Mwale, Fackson and Haglund, Lisbet},
	month = sep,
	year = {2014},
	pmid = {24861010},
	keywords = {Adolescent, Adult, Amino Acid Sequence, Animals, Biological Factors, Cattle, Cells, Cultured, Collagen, Female, Humans, IVD degeneration and regeneration, Intercellular Signaling Peptides and Proteins, Intervertebral Disc, Intervertebral Disc Degeneration, Link N, Lumbar Vertebrae, Male, Middle Aged, Molecular Sequence Data, Peptide Fragments, Proteoglycans, Regeneration, Thoracic Vertebrae, Young Adult, biological repair, organ culture},
	pages = {1189--1197},
}

@article{
 title = {How much do residential aged care staff members know about the nutritional needs of residents?},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Attitude of Health Personnel,Cross-Sectional Studies,Dementia/nursing,Female,Geriatric Nursing/methods,Health Care Surveys,Health Knowledge, Attitudes, Practice,Humans,Male,Malnutrition/nursing,Meals,Middle Aged,Nursing Staff,Nutrition Assessment,Quality of Life/psychology,Residential Facilities,malnutrition,mealtime practices,nutrition knowledge,old age,residential care,staff},
 pages = {54-64},
 volume = {9},
 month = {3},
 publisher = {Blackwell Publishing Ltd},
 city = {Dementia Collaborative Research Centre: Carers & Consumers, Queensland University of Technology, Brisbane, Australia; Dementia Training Studies Centre, Queensland University of Technology, Brisbane, Australia; School of Nursing, Queensland University of T},
 id = {ddcbb97d-cbf9-341d-982c-c02ae2ebd52c},
 created = {2016-08-20T16:52:30.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 74113; CI: (c) 2013; JID: 101267281; OTO: NOTNLM; 2012/08/03 [received]; 2012/11/21 [accepted]; 2013/02/11 [aheadofprint]; ppublish},
 folder_uuids = {06271a48-ad48-43cc-b073-52e57f10f5e1},
 private_publication = {false},
 abstract = {BACKGROUND: Undernutrition, weight loss and dehydration are major clinical issues for people with dementia in residential care, with excessive weight loss contributing to increased risk of frailty, immobility, illness and premature morbidity. This paper discusses a nutritional knowledge and attitudes survey conducted as part of a larger project focused on improving nutritional intake of people with dementia within a residential care facility in Brisbane, Australia. AIMS: The specific aims of the survey were to identify (i) knowledge of the nutritional needs of aged care facility residents; (ii) mealtime practices; and (iii) attitudes towards mealtime practices and organisation. METHODS: A survey based on those used in other healthcare settings was completed by 76 staff members. The survey included questions about nutritional knowledge, opinions of the food service, frequency of feeding assistance provided and feeding assessment practices. RESULTS: Nutritional knowledge scores ranged from 1 to 9 of a possible 10, with a mean score of 4.67. While 76% of respondents correctly identified risk factors associated with malnutrition in nursing home residents, only 38% of participants correctly identified the need for increased protein and energy in residents with pressure ulcers, and just 15% exhibited correct knowledge of fluid requirements. Further, while nutritional assessment was considered an important part of practice by 83% of respondents, just 53% indicated that they actually carried out such assessments. Identified barriers to promoting optimal nutrition included insufficient time to observe residents (56%); being unaware of residents' feeding issues (46%); poor knowledge of nutritional assessments (44%); and unappetising appearance of food served (57%). CONCLUSION: An important step towards improving health and quality of life for residents of aged care facilities would be to enhance staff nutritional awareness and assessment skills. This should be carried out through increased attention to both preservice curricula and on-the-job training. IMPLICATIONS FOR PRACTICE: The residential facility staff surveyed demonstrated low levels of nutrition knowledge, which reflects findings from the international literature. This has implications for the provision of responsive care to residents of these facilities and should be explored further.},
 bibtype = {article},
 author = {Beattie, E and O'Reilly, M and Strange, E and Franklin, S and Isenring, E},
 journal = {International journal of older people nursing},
 number = {1}
}

@article{jhunjhunwala_profile_2014,
	title = {Profile of extrapyramidal manifestations in 85 patients with spinocerebellar ataxia type 1, 2 and 3.},
	volume = {21},
	copyright = {Copyright (c) 2013 Elsevier Ltd. All rights reserved.},
	issn = {1532-2653 0967-5868},
	doi = {10.1016/j.jocn.2013.10.021},
	abstract = {This study aimed to determine the prevalence and type of extrapyramidal signs (EPS) in spinocerebellar ataxia (SCA) type 1, 2 and 3. Eighty-five patients with genetically confirmed SCA (SCA1=40, SCA2=28, SCA3=17) were evaluated for the prevalence and types of EPS. Forty-one SCA patients (48.2\%) had one or more types of EPS. The prevalence of EPS was 60.7\% in SCA2, 52.9\% in SCA3, and 37.5\% in SCA1. Among SCA2 patients, bradykinesia was the most frequent (35.3\%), followed by reduced facial expression, postural tremor and dystonia (29.4\% each), rest tremor, titubation and rigidity (23.5\% each), and lip/jaw tremor and chorea (11.8\% each). In SCA3 the common EPS were bradykinesia (44.4\%), staring look, postural tremor and dystonia (33.3\% each), and reduced facial expression and rigidity (22.2\% each). In SCA1, staring look was the most common (53.3\%), followed by dystonia and bradykinesia (33.3\% each), and postural tremor (26.7\%). In all three groups, there was no significant difference in the mean length of repeat of the abnormal allele between those with and without EPS. To conclude bradykinesia, staring look, dystonia and postural tremor were the most frequent EPS observed in SCA. In SCA1, these signs were seen more often in younger patients with early onset of symptoms.},
	language = {eng},
	number = {6},
	journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
	author = {Jhunjhunwala, Ketan and Netravathi, M. and Purushottam, Meera and Jain, Sanjeev and Pal, Pramod Kumar},
	month = jun,
	year = {2014},
	pmid = {24602359},
	note = {Place: Scotland},
	keywords = {*Alleles, Adult, Basal Ganglia Diseases/*diagnosis/epidemiology/*genetics, Cohort Studies, Dystonia, Extrapyramidal signs, Female, Humans, Male, Middle Aged, Movement disorders, Parkinsonism, Spinocerebellar Ataxias/*diagnosis/epidemiology/*genetics, Spinocerebellar ataxia, Tremor, Young Adult},
	pages = {1002--1006},
}

@article{vytal_sustained_2014,
	title = {Sustained anxiety increases amygdala-dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults.},
	volume = {39},
	copyright = {All rights reserved},
	issn = {1488-2434 1180-4882},
	doi = {10.1503/jpn.130145},
	abstract = {BACKGROUND: Neuroimaging research has traditionally explored fear and anxiety in response to discrete threat cues (e.g., during fear conditioning). However,  anxiety is a sustained aversive state that can persist in the absence of discrete  threats. Little is known about mechanisms that maintain anxiety states over a  prolonged period. Here, we used a robust translational paradigm (threat of shock)  to induce sustained anxiety. Recent translational work has implicated an  amygdala-prefrontal cortex (PFC) circuit in the maintenance of anxiety in  rodents. To explore the functional homologues of this circuitry in humans, we  used a novel paradigm to examine the impact of sustained anticipatory anxiety on  amygdala-PFC intrinsic connectivity. METHODS: Task-independent fMRI data were  collected in healthy participants during long-duration periods of shock  anticipation and safety. We examined intrinsic functional connectivity. RESULTS:  Our study involved 20 healthy participants. During sustained anxiety, amygdala  activity was positively coupled with dorsomedial PFC (DMPFC) activity. High trait  anxiety was associated with increased amygdala-DMPFC coupling. In addition,  induced anxiety was associated with positive coupling between regions involved in  defensive responding, and decreased coupling between regions involved in  emotional control and the default mode network. LIMITATIONS: Inferences regarding  anxious pathology should be made with caution because this study was conducted in  healthy participants. CONCLUSION: Findings suggest that anticipatory anxiety  increases intrinsic amygdala-DMPFC coupling and that the DMPFC may serve as a  functional homologue for the rodent prefrontal regions by sustaining anxiety.  Future research may use this defensive neural context to identify biomarkers of  risk for anxious pathology and target these circuits for therapeutic  intervention.},
	language = {eng},
	number = {5},
	journal = {Journal of psychiatry \& neuroscience : JPN},
	author = {Vytal, Katherine E. and Overstreet, Cassie and Charney, Danielle R. and Robinson, Oliver J. and Grillon, Christian},
	month = sep,
	year = {2014},
	pmid = {24886788},
	pmcid = {PMC4160361},
	note = {Place: Canada},
	keywords = {Adult, Amygdala/*physiopathology, Anticipation, Anticipation, Psychological/physiology, Anxiety/*physiopathology, Brain Mapping, Electroshock, Fear/physiology, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways/physiopathology, Neuropsychological Tests, Personality, Prefrontal Cortex/*physiopathology, Psychological/physiology, Psychophysics, Young Adult},
	pages = {321--329},
}

Paper  doi  abstract   bibtex   

@article{johnson_growing_2014,
	title = {Growing up after extremely preterm birth: {Lifespan} mental health outcomes},
	volume = {19},
	issn = {1744165X},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/24290907},
	doi = {10.1016/j.siny.2013.11.004},
	abstract = {There is growing interest in the long-term mental health sequelae of extremely preterm birth. In this paper we review literature relating to mental health outcomes across the lifespan. Studies conducted in the preschool years, school age and adolescence, and adulthood show continuity in outcomes and point to an increased risk for inattention, socio-communicative problems and emotional difficulties in individuals born extremely preterm. Both behavioural and neuroimaging studies also provide evidence of a neurodevelopmental origin for mental health disorders in this population. Here we summarise contemporary evidence and highlight key methodological considerations for carrying out and interpreting studies in this field.},
	number = {2},
	urldate = {2015-03-11},
	journal = {Seminars in Fetal and Neonatal Medicine},
	author = {Johnson, Samantha and Marlow, Neil},
	month = apr,
	year = {2014},
	pmid = {24290907},
	keywords = {Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: dia, Child, Child Behavior Disorders, Child Behavior Disorders: diagnosis, Child, Preschool, Developmental Disabilities, Developmental Disabilities: diagnosis, Humans, Infant, Extremely Premature, Infant, Newborn, Mental Health, Risk Factors},
	pages = {97--104},
}

@article{wiwatanadate_acute_2014,
	title = {Acute air pollution-related symptoms among residents in {Chiang} {Mai}, {Thailand}},
	volume = {76},
	issn = {0022-0892},
	abstract = {Open burnings (forest fires, agricultural, and garbage burnings) are the major sources of air pollution in Chiang Mai, Thailand. A time series prospective study was conducted in which 3025 participants were interviewed for 19 acute symptoms with the daily records of ambient air pollutants: particulate matter less than 10 microm in size (PM10), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3). PM10 was positively associated with blurred vision with an adjusted odds ratio (OR) of 1.009. CO was positively associated with lower lung and heart symptoms with adjusted ORs of 1.137 and 1.117. NO2 was positively associated with nosebleed, larynx symptoms, dry cough, lower lung symptoms, heart symptoms, and eye irritation with the range of adjusted ORs (ROAORs) of 1.024 to 1.229. SO2 was positively associated with swelling feet, skin symptoms, eye irritation, red eyes, and blurred vision with ROAORs of 1.205 to 2.948. Conversely, O3 was negatively related to running nose, burning nose, dry cough, body rash, red eyes, and blurred vision with ROAORs of 0.891 to 0.979.},
	language = {eng},
	number = {6},
	journal = {Journal of Environmental Health},
	author = {Wiwatanadate, Phongtape},
	month = feb,
	year = {2014},
	pmid = {24645417},
	note = {00003 },
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Environmental Exposure, Female, Humans, Male, Middle Aged, Odds Ratio, Particulate Matter, Prospective Studies, Respiration Disorders, Thailand, Weather},
	pages = {76--84}
}

@article{taylor_all-cause_2013,
	title = {All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large {U}.{K}. primary care database},
	volume = {36},
	issn = {1935-5548},
	doi = {10.2337/dc12-1513},
	abstract = {OBJECTIVE: Middle-aged people with diabetes have been reported to have significantly higher risks of cardiovascular events than people without diabetes. However, recent falls in cardiovascular disease rates and more active management of risk factors may have abolished the increased risk. We aimed to provide an up-to-date assessment of the relative risks associated with type 2 diabetes of all-cause and cardiovascular mortality in middle-aged people in the U.K.
RESEARCH DESIGN AND METHODS: Using data from the General Practice Research Database, from 2004 to 2010, we conducted a cohort study of 87,098 people, 40-65 years of age at baseline, comparing 21,798 with type 2 diabetes and 65,300 without diabetes, matched on age, sex, and general practice. We produced hazard ratios (HRs) for mortality and compared rates of blood pressure testing, cholesterol monitoring, and use of aspirin, statins, and antihypertensive drugs. RESULTS People with type 2 diabetes, compared with people without diabetes, had a twofold increased risk of all-cause mortality (HR 2.07 [95\% CI 1.95-2.20], adjusted for smoking) and a threefold increased risk of cardiovascular mortality (3.25 [2.87-3.68], adjusted for smoking). Women had a higher relative risk than men, and people {\textless}55 years of age had a higher relative risk than those {\textgreater}55 years of age. Monitoring and medication rates were higher in those with diabetes (all P {\textless} 0.001).
CONCLUSIONS: Despite efforts to manage risk factors, administer effective treatments, and develop new therapies, middle-aged people with type 2 diabetes remain at significantly increased risk of death.},
	language = {eng},
	number = {8},
	journal = {Diabetes Care},
	author = {Taylor, Kathryn S. and Heneghan, Carl J. and Farmer, Andrew J. and Fuller, Alice M. and Adler, Amanda I. and Aronson, Jeffrey K. and Stevens, Richard J.},
	month = aug,
	year = {2013},
	pmid = {23435157},
	pmcid = {PMC3714501},
	keywords = {Adult, Cardiovascular Diseases, Cause of Death, Databases, Factual, Diabetes Mellitus, Type 2, Female, Great Britain, Humans, Male, Middle Aged, Risk, Sex Factors},
	pages = {2366--2371}
}

Paper  doi  abstract   bibtex   

@article{bourne_neuropsychological_2013,
	title = {Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis.},
	volume = {128},
	issn = {1600-0447},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23617548},
	doi = {10.1111/acps.12133},
	abstract = {OBJECTIVE: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view.

METHOD: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task.

RESULTS: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression.

CONCLUSION: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment.},
	number = {3},
	urldate = {2015-05-01},
	journal = {Acta psychiatrica Scandinavica},
	author = {Bourne, C and Aydemir, Ö and Balanzá-Martínez, V and Bora, E and Brissos, S and Cavanagh, J T O and Clark, L and Cubukcuoglu, Z and Dias, V V and Dittmann, S and Ferrier, I N and Fleck, D E and Frangou, S and Gallagher, P and Jones, L and Kieseppä, T and Martínez-Aran, A and Melle, I and Moore, P B and Mur, M and Pfennig, A and Raust, A and Senturk, V and Simonsen, C and Smith, D J and Bio, D S and Soeiro-de-Souza, M G and Stoddart, S D R and Sundet, K and Szöke, A and Thompson, J M and Torrent, C and Zalla, T and Craddock, N and Andreassen, O A and Leboyer, M and Vieta, E and Bauer, M and Worhunsky, P D and Tzagarakis, C and Rogers, R D and Geddes, J R and Goodwin, G M},
	month = sep,
	year = {2013},
	pmid = {23617548},
	keywords = {Adult, Affect, Affective Symptoms, Affective Symptoms: psychology, Age of Onset, Bipolar Disorder, Bipolar Disorder: complications, Bipolar Disorder: diagnosis, Bipolar Disorder: drug therapy, Bipolar Disorder: epidemiology, Cognition Disorders, Cognition Disorders: diagnosis, Cognition Disorders: drug therapy, Cognition Disorders: epidemiology, Cognition Disorders: etiology, Confounding Factors (Epidemiology), Female, Humans, Male, Mental Competency, Mental Processes, Mental Processes: drug effects, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Psychotropic Drugs, Psychotropic Drugs: administration \& dosage, Psychotropic Drugs: adverse effects, Risk Factors},
	pages = {149--62},
}

Website  abstract   bibtex   

@article{
 title = {Are forward and backward recall the same? A dual-task study of digit recall.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Adult,Attention,Attention: physiology,Executive Function,Executive Function: physiology,Humans,Mathematical Concepts,Mental Recall,Mental Recall: physiology,Space Perception,Space Perception: physiology,Young Adult},
 pages = {519-32},
 volume = {41},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/23263876},
 id = {99159d3e-5274-3213-bef9-d024aca4812a},
 created = {2016-01-12T16:04:56.000Z},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {There is some debate surrounding the cognitive resources underlying backward digit recall. Some researchers consider it to differ from forward digit recall due to the involvement of executive control, while others suggest that backward recall involves visuospatial resources. Five experiments therefore investigated the role of executive-attentional and visuospatial resources in both forward and backward digit recall. In the first, participants completed visuospatial 0-back and 2-back tasks during the encoding of information to be remembered. The concurrent tasks did not differentially disrupt performance on backward digit recall, relative to forward digit recall. Experiment 2 shifted concurrent load to the recall phase instead and, in this case, revealed a larger effect of both tasks on backward recall, relative to forwards recall, suggesting that backward recall may draw on additional resources during the recall phase and that these resources are visuospatial in nature. Experiments 3 and 4 then further investigated the role of visual processes in forward and backward recall using dynamic visual noise (DVN). In Experiment 3, DVN was presented during encoding of information to be remembered and had no effect upon performance. However, in Experiment 4, it was presented during the recall phase, and the results provided evidence of a role for visual imagery in backward digit recall. These results were replicated in Experiment 5, in which the same list length was used for forward and backward recall tasks. The findings are discussed in terms of both theoretical and practical implications.},
 bibtype = {article},
 author = {St Clair-Thompson, H. L. and Allen, R. J.},
 journal = {Memory & cognition},
 number = {4}
}

Paper  doi  bibtex   

@article{robinson_role_2013,
	title = {The role of serotonin in the neurocircuitry of negative affective bias: {Serotonergic} modulation of the dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit},
	volume = {78},
	copyright = {All rights reserved},
	issn = {1053-8119},
	shorttitle = {The role of serotonin in the neurocircuitry of negative affective bias: {Serotonergic} modulation of the dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit},
	url = {http://www.sciencedirect.com/science/article/pii/S1053811913003303},
	doi = {10.1016/j.neuroimage.2013.03.075},
	journal = {Neuroimage},
	author = {Robinson, Oliver J. and Overstreet, Cassie and Allen, Philip S. and Letkiewicz, Alison and Vytal, Katherine and Pine, Daniel S. and Grillon, Christian},
	year = {2013},
	note = {0},
	keywords = {ATD, Adult, Affect/drug effects/physiology, Affective Symptoms, Amygdala, Amygdala/*metabolism/physiopathology, Anxiety/metabolism/physiopathology, Aversive amplification, Bias, Computer-Assisted, Cross-Over Studies, DMPFC, Depression/metabolism/physiopathology, Double-Blind Method, Emotions/drug effects/physiology, Female, Humans, Image Interpretation, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Negative bias, Neural Pathways/*metabolism/physiopathology, Prefrontal Cortex/*metabolism/physiopathology, Serotonin Receptor Agonists/pharmacology, Serotonin/*metabolism, Tryptophan/pharmacology, serotonin},
	pages = {217--223},
}

@article{cameron_development_2013,
	title = {The development of scientific communication skills: a qualitative study of the perceptions of trainees and their mentors},
	volume = {88},
	issn = {1938-808X},
	shorttitle = {The development of scientific communication skills},
	doi = {10.1097/ACM.0b013e3182a34f36},
	abstract = {PURPOSE: Scientific communication, both written and oral, is the cornerstone of success in biomedical research, yet formal instruction is rarely provided. Trainees with little exposure to standard academic English may find developing scientific communication skills challenging. In this exploratory, hypothesis-generating qualitative study, the authors examined the process by which mentored junior researchers learn scientific communication skills, their feelings about the challenges, and their mentor's role in the process.
METHOD: In 2010, the authors conducted semistructured focus groups and interviews to explore research trainees' and faculty mentors' perceptions and practices regarding scientific communication skills development, as part of the development phase of a larger quantitative study. The facilitator took detailed notes and verified their accuracy with participants during the sessions; a second member of the research team observed and verified the recorded notes. Three coders performed a thematic analysis, and the other authors reviewed it.
RESULTS: Forty-three trainees and 50 mentors participated. Trainees and mentors had diverging views on the role of mentoring in fostering communication skills development. Trainees expressed varying levels of self-confidence but considerable angst. Mentors felt that most trainees have low self-confidence. Trainees expressed interest in learning scientific communication skills, but mentors reported that some trainees were insufficiently motivated and seemed resistant to guidance. Both groups agreed that trainees found mentors' feedback difficult to accept.
CONCLUSIONS: The degree of distress, dissatisfaction, and lack of mutual understanding between mentors and trainees was striking. These themes have important implications for best practices and resource development.},
	language = {eng},
	number = {10},
	journal = {Academic Medicine: Journal of the Association of American Medical Colleges},
	author = {Cameron, Carrie and Collie, Candice L. and Baldwin, Constance D. and Bartholomew, L. Kay and Palmer, J. Lynn and Greer, Marilyn and Chang, Shine},
	month = oct,
	year = {2013},
	pmid = {23969363},
	pmcid = {PMC3809893},
	keywords = {Adult, Biomedical Research, Communication, Female, Focus Groups, Humans, Interviews as Topic, Language, Male, Mentors, Perception, Qualitative Research, Research Personnel},
	pages = {1499--1506},
}

Website  abstract   bibtex   

@article{
 title = {Dynamic data during hypotensive episode improves mortality predictions among patients with sepsis and hypotension.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {80 and over,Adult,Aged,Algorithms,Cohort Studies,Comorbidity,Critical Illness,Critical Illness: mortality,Female,Great Britain,Hospital Mortality,Hospital Mortality: trends,Humans,Hypotension,Hypotension: mortality,Intensive Care Units,Male,Middle Aged,Outcome Assessment (Health Care),Predictive Value of Tests,Prognosis,Retrospective Studies,Sepsis,Sepsis: mortality},
 pages = {954-62},
 volume = {41},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3609896&tool=pmcentrez&rendertype=abstract},
 month = {4},
 publisher = {NIH Public Access},
 id = {95d7042f-e668-3f25-aeb3-4f00b98dda28},
 created = {2016-03-29T18:26:56.000Z},
 file_attached = {false},
 profile_id = {304786e8-5116-360a-80be-e62833097578},
 group_id = {d7b44578-07c1-3210-ae74-3bcd7f980767},
 last_modified = {2017-03-14T15:45:25.917Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Mayaud_Crit_Care_April_2013},
 source_type = {article},
 private_publication = {false},
 abstract = {OBJECTIVES: To determine if a prediction rule for hospital mortality using dynamic variables in response to treatment of hypotension in patients with sepsis performs better than current models.\n\nDESIGN: Retrospective cohort study.\n\nSETTING: All ICUs at a tertiary care hospital.\n\nPATIENTS: Adult patients admitted to ICUs between 2001 and 2007 of whom 2,113 met inclusion criteria and had sufficient data.\n\nINTERVENTIONS: None.\n\nMEASUREMENTS AND MAIN RESULTS: We developed a prediction algorithm for hospital mortality in patients with sepsis and hypotension requiring medical intervention using data from the Multiparameter Intelligent Monitoring in Intensive Care II. We extracted 189 candidate variables, including treatments, physiologic variables and laboratory values collected before, during, and after a hypotensive episode. Thirty predictors were identified using a genetic algorithm on a training set (n=1500) and validated with a logistic regression model on an independent validation set (n=613). The final prediction algorithm used included dynamic information and had good discrimination (area under the receiver operating curve=82.0%) and calibration (Hosmer-Lemeshow C statistic=10.43, p=0.06). This model was compared with Acute Physiology and Chronic Health Evaluation IV using reclassification indices and was found to be superior with an Net Reclassification Improvement of 0.19 (p<0.001) and an Integrated Discrimination Improvement of 0.09 (p<0.001).\n\nCONCLUSIONS: Hospital mortality predictions based on dynamic variables surrounding a hypotensive event is a new approach to predicting prognosis. A model using these variables has good discrimination and calibration and offers additional predictive prognostic information beyond established ones.},
 bibtype = {article},
 author = {Mayaud, Louis and Lai, Peggy S and Clifford, Gari D and Tarassenko, Lionel and Celi, Leo Anthony and Annane, Djillali},
 journal = {Critical Care Medicine},
 number = {4}
}

Paper  abstract   bibtex   

@article{
 title = {A multi-center retrospective analysis of treatment effects and quality of life in adult patients with cranial ependymomas},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Brain Neoplasms,Brain Neoplasms: mortality,Brain Neoplasms: pathology,Brain Neoplasms: therapy,Combined Modality Therapy,Cranial Irradiation,Ependymoma,Ependymoma: mortality,Ependymoma: pathology,Ependymoma: therapy,Female,Follow-Up Studies,Humans,Male,Middle Aged,Neurosurgical Procedures,Prognosis,Quality of Life,Retrospective Studies,Survival Rate,Young Adult},
 pages = {319-27},
 volume = {114},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/23813228},
 month = {9},
 id = {f45c71d6-e421-3cd5-8da7-0d79c822397d},
 created = {2014-04-16T20:14:36.000Z},
 accessed = {2014-04-16},
 file_attached = {true},
 profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T21:45:19.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Long term quality of life data of adult patients harboring intracranial ependymomas have not been reported. The role of adjuvant radiation therapy in Grade II ependymomas is unclear and differs from study to study. We therefore sought to retrospectively analyze outcome and quality of life of adult patients that were operated on intracranial ependymomas at four different surgical centers in two countries. All patients were attempted to be contacted via telephone to assess quality of life (QoL) at the time of the telephone interview. The standard EORTC QoL Questionnaire C30 (EORTC QLQ-C30) and the EORTC QLQ-Brain Cancer Module (QLQ-BN20) were used. 64 adult patients with intracranial ependymomas were included in the study. The only factor that was associated with increased survival was age <55 years (p < 0.001). Supratentorial location was correlated with shorter progression free survival than infratentorial location (PFS; p = 0.048). In WHO Grade II tumors local irradiation did not lead to increased PFS (p = 0.888) or overall survival (p = 0.801). Even for incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS (p = 0.911). In a multivariate analysis of QoL, irradiated patients had significantly worse scores in the item "fatigue" (p = 0.037) than non-irradiated patients. Here we present QoL data of adult patients with intracranial ependymomas. Our data show that local radiation therapy may have long-term effects on patients' QoL. Since in the incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS in this retrospective study, prospective randomized studies are necessary. In addition to age, supratentorial tumor location is associated with a worse prognosis in adult ependymoma patients.},
 bibtype = {article},
 author = {Dützmann, Stephan and Schatlo, Bawarjan and Lobrinus, Alexander and Murek, Michael and Wostrack, Maria and Weiss, Carolin and Schaller, Karl and Raabe, Andreas and Meyer, Bernhard and Goldbrunner, Roland and Franz, Kea and Seifert, Volker and Senft, Christian},
 journal = {Journal of Neuro-Oncology},
 number = {3}
}

@article{ radua_new_2012,
  title = {A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps},
  volume = {27},
  issn = {1778-3585},
  doi = {10.1016/j.eurpsy.2011.04.001},
  abstract = {Meta-analyses are essential to summarize the results of the growing number of neuroimaging studies in psychiatry, neurology and allied disciplines. Image-based meta-analyses use full image information (i.e. the statistical parametric maps) and well-established statistics, but images are rarely available making them highly unfeasible. Peak-probability meta-analyses such as activation likelihood estimation (ALE) or multilevel kernel density analysis (MKDA) are more feasible as they only need reported peak coordinates. Signed-differences methods, such as signed differential mapping (SDM) build upon the positive features of existing peak-probability methods and enable meta-analyses of studies comparing patients with controls. In this paper we present a new version of SDM, named Effect Size SDM (ES-SDM), which enables the combination of statistical parametric maps and peak coordinates and uses well-established statistics. We validated the new method by comparing the results of an ES-SDM meta-analysis of studies on the brain response to fearful faces with the results of a pooled analysis of the original individual data. The results showed that ES-SDM is a valid and reliable coordinate-based method, whose performance might be additionally increased by including statistical parametric maps. We anticipate that ES-SDM will be a helpful tool for researchers in the fields of psychiatry, neurology and allied disciplines.},
  language = {eng},
  number = {8},
  journal = {European Psychiatry: The Journal of the Association of European Psychiatrists},
  author = {Radua, J. and Mataix-Cols, D. and Phillips, M. L. and El-Hage, W. and Kronhaus, D. M. and Cardoner, N. and Surguladze, S.},
  month = {November},
  year = {2012},
  pmid = {21658917},
  keywords = {Adult, Brain, Brain Mapping, Facial Expression, Humans, Magnetic Resonance Imaging, Neuroimaging, Neuropsychological Tests, Reproducibility of Results},
  pages = {605--611}
}

Website  abstract   bibtex   

@article{
 title = {Quantitative evaluation of white matter tract DTI parameter changes in gliomas using nonlinear registration.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Anisotropy,Brain Mapping,Brain Mapping: methods,Brain Neoplasms,Brain Neoplasms: pathology,Computer-Assisted,Diffusion Magnetic Resonance Imaging,Diffusion Magnetic Resonance Imaging: methods,Female,Glioma,Glioma: pathology,Humans,Image Interpretation,Male,Middle Aged},
 pages = {2309-15},
 volume = {60},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22387173},
 month = {5},
 day = {1},
 id = {52c453a0-39cf-3063-98b2-f969182bb93f},
 created = {2014-02-21T01:56:21.000Z},
 accessed = {2014-01-28},
 file_attached = {false},
 profile_id = {c9197201-0e1b-30a7-a154-39d024463beb},
 last_modified = {2017-03-16T10:25:05.903Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {Diffusion tensor imaging (DTI) has been used extensively to investigate white matter architecture in the brain. In the context of neurological disease, quantification of DTI data sets enables objective characterisation of the associated pathological changes. The aim of this study is to propose a method of evaluating DTI parameter changes in gliomas in the internal capsule using nonlinear registration to delineate the white matter and enable quantitative assessment of DTI derived parameters. 20 patients selected pre-operatively with probable grade 2 or grade 3 glioma on structural MRI along with ten normal volunteers were included in this study. DTI fractional anisotropy (FA) maps were used to define a common segmented FA skeleton that was projected back onto the original individual FA maps. Objective segment classification as normal or abnormal was achieved by comparison to prediction intervals of FA and mean diffusivity (MD) defined in normal subjects. The internal capsules of each patient were segmented into 10 regions of interest (ROI) with 20 and 16 segments across the group having significantly increased or decreased FA and MD values respectively. Seven glioma patients had abnormal DTI parameters in the internal capsule. We show that the classification of tract segments was consistent with disruption, oedema or compression. The results suggest that this method could be used to detect changes in eloquent white matter tracts in individual patients.},
 bibtype = {article},
 author = {Miller, P and Coope, D and Thompson, G and Jackson, A and Herholz, K},
 journal = {NeuroImage},
 number = {4}
}

Website  abstract   bibtex   

@article{
 title = {Blood/air distribution of volatile organic compounds (VOCs) in a nationally representative sample.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Air Pollutants,Air Pollutants: analysis,Air Pollutants: blood,Child,Chlorobenzenes,Chlorobenzenes: analysis,Chlorobenzenes: blood,Drinking Water,Environmental Monitoring,Female,Gas Chromatography-Mass Spectrometry,Humans,Linear Models,Male,Middle Aged,Multivariate Analysis,Nutrition Surveys,Questionnaires,Smoking,Smoking: blood,Solid Phase Microextraction,United States,Volatile Organic Compounds,Volatile Organic Compounds: analysis,Volatile Organic Compounds: blood,Young Adult},
 pages = {225-32},
 volume = {419},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22285084},
 publisher = {Elsevier B.V.},
 id = {33341907-add2-3a89-9999-74cba0377b37},
 created = {2015-03-09T20:40:30.000Z},
 file_attached = {true},
 profile_id = {03bdbf9c-0848-344e-95e3-9d552532f95c},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 folder_uuids = {94112c8a-2c34-4696-add4-3937d89cec61},
 private_publication = {false},
 abstract = {Volatile organic compounds (VOCs) in human blood are an effective biomarker of environmental exposure and are closely linked to health outcomes. Unlike VOC concentrations in air, which are routinely collected, blood VOC data are not as readily available. This study aims to develop the quantitative relationship between air and blood VOCs by deriving population-based blood/air distribution coefficients (popKs) of ten common VOCs in the general U.S. population. Air and human blood samples were collected from 364 adults aged 20-59 years in 1999-2000 National Health and Nutrition Examination Survey (NHANES). Determinants of popKs were identified using weighted multivariate regression models. In the non-smoking population, median popKs ranged from 3.1 to 77.3, comparable to values obtained in the laboratory. PopKs decreased with increasing airborne VOC concentrations. Smoking elevated popKs by 1.5-3.5 times for aromatic compounds, but did not affect the popKs for methyl tert-butyl ether (MTBE) or chlorinated compounds. Drinking water concentration was a modifier of MTBE's popK. Age, gender, body composition, nor ethnicity affected popKs. PopKs were predictable using linear models with air concentration as the independent variable for both adults and children. This is the first study to estimate blood/air distribution coefficients using simultaneous environmental and biological monitoring on a national population sample. This study was also the first to determine the blood/air distribution coefficient of p-dichlorobenzene, a compound frequently found in indoor environments. These results have applications in exposure assessment, pharmacokinetic analysis, physiologically-based pharmacokinetic (PBPK) modeling, and uncertainty analysis.},
 bibtype = {article},
 author = {Jia, Chunrong and Yu, Xinhua and Masiak, Wasim},
 journal = {The Science of the total environment}
}

Paper  doi  abstract   bibtex   

@article{hirai_distribution_2012,
	title = {Distribution of polybrominated diphenyl ethers in {Japanese} autopsy tissue and body fluid samples.},
	volume = {19},
	issn = {1614-7499},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22544599},
	doi = {10.1007/s11356-012-0915-z},
	abstract = {Brominated flame retardants are components of many plastics and are used in products such as cars, textiles, televisions, and personal computers. Human exposure to polybrominated diphenyl ether (PBDE) flame retardants has increased exponentially during the last three decades. Our objective was to measure the body burden and distribution of PBDEs and to determine the concentrations of the predominant PBDE congeners in samples of liver, bile, adipose tissue, and blood obtained from Japanese autopsy cases. Tissues and body fluids obtained from 20 autopsy cases were analyzed. The levels of 25 PBDE congeners, ranging from tri- to hexa-BDEs, were assessed. The geometric means of the sum of the concentrations of PBDE congeners having detection frequencies {\textbackslash}textgreater50 \% (ΣPBDE) in the blood, liver, bile, and adipose tissue were 2.4, 2.6, 1.4, and 4.3 ng/g lipid, respectively. The most abundant congeners were BDE-47 and BDE-153, followed by BDE-100, BDE-99, and BDE-28+33. These concentrations of PBDE congeners were similar to other reports of human exposure in Japan but were notably lower than concentrations than those reported in the USA. Significant positive correlations were observed between the concentrations of predominant congeners and ΣPBDE among the samples analyzed. The ΣPBDE concentration was highest in the adipose tissue, but PBDEs were distributed widely among the tissues and body fluids analyzed. The PBDE levels observed in the present study are similar to those reported in previous studies in Japan and significantly lower than those reported in the USA.},
	number = {8},
	journal = {Environmental science and pollution research international},
	author = {Hirai, Tetsuya and Fujimine, Yoshinori and Watanabe, Shaw and Nakano, Takeshi},
	month = sep,
	year = {2012},
	pmid = {22544599},
	keywords = {80 and over, Adipose Tissue, Adipose Tissue: chemistry, Adult, Aged, Asian Continental Ancestry Group, Bile, Bile: chemistry, Body Burden, Cadaver, Female, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Halogenated Diphenyl Ethers: blood, Humans, Liver, Liver: chemistry, Male, Middle Aged},
	pages = {3538--46},
}

@article{looker_lumbar_2012-1,
	title = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: {United} {States}, 2005-2008},
	issn = {0083-1980},
	shorttitle = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area},
	abstract = {OBJECTIVE: This report presents bone measurement data from dual-energy X-ray absorptiometry scans of the lumbar spine and proximal femur for persons aged 8 years and over from the National Health and Nutrition Examination Survey (NHANES) 2005-2008.
METHODS: Means, standard deviations, and selected percentiles were calculated for the proximal femur and lumbar spine (total and subregions) by sex, race and ethnicity, and age. Smoothed mean total lumbar spine and femur neck bone mineral density (BMD) were plotted by age, sex, and race and ethnicity. Multiple regression was used to test for significant interactions and to calculate mean total lumbar spine and femur neck BMD after adjusting for age, sex, and race and ethnicity. Differences by sex, race and ethnicity, and age were summarized by calculating the percent difference in adjusted means.
RESULTS: Among scanned individuals, 11\% lacked total lumbar spine data due to invalid data for one or more lumbar vertebrae, and 4\% had invalid data for the proximal femur. Non-Hispanic black persons had 6\% higher total lumbar spine BMD and 9\%-10\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD and femur neck BMD did not differ between Mexican-American and non-Hispanic white persons in those under age 20. For those aged 20 and over, Mexican-American persons had 4\% lower total lumbar spine BMD but 1\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD was 8\%-17\% higher in females aged 8-15 compared with males of the same age. In the age group 16-49, mean total lumbar spine BMD was similar or slightly higher for females compared with males, but after age 50 it was 60\%-15\% lower for females compared with males. Mean femur neck BMD was 5\%-13\% lower for females than males in all age groups except 12-15.},
	language = {eng},
	number = {251},
	journal = {Vital and Health Statistics. Series 11, Data from the National Health Survey},
	author = {Looker, Anne C. and Borrud, Lori G. and Hughes, Jeffery P. and Fan, Bo and Shepherd, John A. and Melton, L. Joseph},
	month = mar,
	year = {2012},
	pmid = {24261130},
	keywords = {Absorptiometry, Photon, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bone Density, Child, Ethnic Groups, Female, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Nutrition Surveys, Regression Analysis, Sex Factors, United States, Young Adult},
	pages = {1--132}
}

@article{spoendlin_study_2012,
	title = {A study on the epidemiology of rosacea in the {U}.{K}},
	volume = {167},
	issn = {1365-2133},
	doi = {10.1111/j.1365-2133.2012.11037.x},
	abstract = {BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09\% to 22\%. To our knowledge, incidence rates have not been quantified before.
OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5\% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80\% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8\% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95\% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.},
	language = {eng},
	number = {3},
	journal = {The British Journal of Dermatology},
	author = {Spoendlin, J. and Voegel, J. J. and Jick, S. S. and Meier, C. R.},
	month = sep,
	year = {2012},
	pmid = {22564022},
	keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alcohol Drinking, Child, Child, Preschool, Diagnosis, Differential, Epidemiologic Methods, Female, Great Britain, Humans, Infant, Life Style, Male, Middle Aged, Rosacea, Smoking, Young Adult, incidence},
	pages = {598--605}
}

@article{bhargav_evidence_2012,
	title = {Evidence for extended age dependent maternal immunity in infected children: mother to child transmission of {HIV} infection and potential interventions including  sulfatides of the human fetal adnexa and complementary or alternative medicines.},
	volume = {7},
	issn = {1556-8539},
	abstract = {The two neighboring southwestern states of India, Karnataka and Maharashtra, have high incidence of HIV/AIDS and are among the six most high prevalence HIV infected  states. In Karnataka state, the northern districts of Bagalkot, Belgaum and Bijapur  (the three Bs) and in Maharashtra state, the southern districts of Sangli, Satara,  and Solapur (the three Ss) are the areas with the highest incidence of HIV/AIDS. We  have evaluated the incidence of maternal to child transmission (MTCT) of HIV-1  infection in Belgaum District which is more than 500 kilometers distance by road  from the campus in greater Bangalore (Karnataka State). We have obtained the  prenatal CD4 counts of HIV infected pregnant mothers. We have also screened the HIV  infected children in two orphanages (rehabilitation centres for HIV infected  children) in Belgaum District. The clinical conditions of these infected children  were assessed for their CD4 counts, anti-retroviral therapy (ART) intake status,  outpatient illnesses and body composition. We have observed that there is an  influence of the age factor on the CD4 counts of the HIV infected children. Further,  in view of the role of our recently found involvement of sulfatide, 3-O-  galactosylceramide, in inhibition of HIV-1 replication and enhancement of  hematopoiesis which is otherwise inhibited due to such infection, we have discussed  the possible role of sulfatides that biologically occur in the fetal adnexa  (placentatrophoblasts /amnion/chorion-umbilical cord), in containing HIV infection  as a potential safer alternative to the ART regimens currently approved to be  clinically practiced. Lastly, we have discussed the complementary and alternative  medicine (CAM) therapies such as evidence based yoga and ayurveda as add-on to ART  in potential elimination of MTCT of HIV infection. Out of a total of 150 children  delivered by HIV infected mothers, 13 children were found to be positive as  determined by the dried blood smear (DBS) for virological testing, giving an  incidence of about 8.66\% in the Belgaum district during the last two years, in spite  of the prescription of currently available ART regimens. All the 13 HIV-transmitting  mothers had normal vaginal deliveries. Though 12\% of the total 150 deliveries  required lower segment caesarean section (LSCS), none among them resulted in MTCT of  HIV. Comparison of the prenatal CD4 counts between transmitting and non-transmitting  mothers did not show significant differences (p=0.25) thus suggesting indirectly  that HIV-1 proviral loads (undetermined / unavailable) need not necessarily  determine the fate of incidence of vertical transmission. The mean age of 44 HIV  infected children (14 females, 30 males) that were screened in two orphanages was  10.8±3.1 years. Out of these 44 children, 27 were taking ART (61.36\%) with mean  duration of consumption being 2.8±2.28 years. Fifty percent (n=22) of the children  were suffering from at least one outpatient illness, out of which 13 were taking  ART. Their mean basal metabolic rate (BMR), body mass index (BMI), muscle mass, fat  mass and fat \% were 795.45±106.9, 14.55±1.9 kg/m(2), 9.54±3.4 kg, 3.69±2.24 kg and  15.04±7.8\% respectively. Comparison between the children taking ART (on-ART, n=27)  and those not taking ART (non-ART, n= 17) showed that though there was no  significant difference in the average age of the two groups, on-ART children had  significantly higher BMR (p=0.05), and muscle mass (p=0.004), than non-ART. The CD4  counts, BMI, fat mass and fat percentage did not show significant statistical  differences between the two groups. The CD4 counts of the children (both on-ART and  non-ART) of age 8 years and below (n=12) were found to be significantly higher  (p=0.04) than those of age 14 and above (n=10). All the children in age group of 14  years and above (n=10) except one child were on ART, whereas 7 out of 12 children in  age group of 8 years and below were on-ART. In one of the rehabilitation centers  called Aadhar, among non-ART children, a significant correlation was observed  between the age of the child and CD4 counts (measured separately in the months of  June 2011 and December 2011). Both the CD4 counts measured in June 2011 (n=6;  r=-0.82, p= 0.04) as well as in December 2011 (n=6; r=-0.97, p=0.001) showed a  significant decline as the age progressed. Also, at the same center, among on-ART  children, the CD4 counts in June 2011 (n=7) and December 2011 (n=8) were  significantly different between the children in the age group of 8 below years, and  those in the age group of 14 years and above (p= 0.005). As HIV infected children  grow in age, they may lose maternal derived immunity as shown by the decrease in CD4  counts, irrespective of their ART status. It is to be expected from these results  that the conferred maternal immunity (possibly primarily humoral and secondarily  cytotoxic immune responses) to the virus acquired at child birth taper off and  eventually overcome by the generation of mutant HIV strains in the children, as the  life spans of the infected children progress. We have discussed safer therapeutic  interventions whose efficacy on HIV/AIDS may be synergistic to or even substitute  the existing treatment strategies. Some of such interventions may even be customized  to help eliminate MTCT. Further, these virus infected pregnant mother patient blood  / serum samples could prove useful in the vaccine development against HIV infection.},
	language = {eng},
	number = {3},
	journal = {Journal of stem cells},
	author = {Bhargav, Hemant and Huilgol, Vidya and Metri, Kashinath and Sundell, I. Birgitta and Tripathi, Satyam and Ramagouda, Nagaratna and Jadhav, Mahesh and Raghuram, Nagarathna and Ramarao, Nagendra Hongasandra and Koka, Prasad S.},
	year = {2012},
	pmid = {23619381},
	note = {Place: United States},
	keywords = {Humans, Adolescent, Adult, Female, Male, India, Age Factors, Pregnancy, Child, Child, Preschool, *Complementary Therapies, Amnion/immunology/metabolism/virology, Anti-Retroviral Agents/*therapeutic use, CD4 Lymphocyte Count, Chorion/immunology/metabolism/virology, HIV Infections/drug therapy/immunology/*transmission, HIV-1/drug effects/isolation \& purification, Infant, Infectious Disease Transmission, Vertical/*prevention \& control, Mothers, Placenta/immunology/metabolism/virology, Pregnancy Complications, Infectious/immunology/*virology, Sulfoglycosphingolipids/*therapeutic use, Umbilical Cord/immunology/metabolism/virology, Viral Load},
	pages = {127--153}
}

Paper  doi  bibtex   

@article{budzik_jf_diffusion_2011,
title = {Diffusion tensor imaging and fibre tracking in cervical spondylotic myelopathy},
volume = {21},
issn = {0938-7994},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20725834},
DOI = {10.1007/s00330-010-1927-z},
Language = {English},
Journal = {Eur. Radiol.},
author = {{Budzik JF} and {Balbi V} and {Le Thuc V} and {Duhamel A} and {Assaker R} and {Cotten A}},
year = {2011},
keywords = {Adult, Aged, Diffusion Tensor Imaging/methods*, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated/pathology*, Reproducibility of Results, Sensitivity and Specificity, Spinal Cord Compression/etiology*, Spinal Cord Compression/pathology*, Spondylosis/complications*, Spondylosis/pathology*},
pages = {426-433}
}

Paper  doi  abstract   bibtex   

@article{luchinger_eegbold_2011,
	title = {{EEG}–{BOLD} correlations during (post-) adolescent brain maturation},
	volume = {56},
	issn = {10538119},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21349336},
	doi = {10.1016/j.neuroimage.2011.02.050},
	abstract = {The transition from adolescence to adulthood is a critical stage in the human lifespan during which the brain still undergoes substantial structural and functional change. The changing frequency composition of the resting state EEG reflects maturation of brain function. This study investigated (post)adolescent brain maturation captured by two independently but simultaneously recorded neuronal signals: EEG and fMRI. Data were collected in a 20 min eyes-open/eyes-closed resting state paradigm. EEG, fMRI-BOLD signal and EEG-BOLD correlations were compared between groups of adults, age 25 (n=18), and adolescents, age 15 (n=18). A typical developmental decrease of low-frequency EEG power was observed even at this late stage of brain maturation. Frequency and condition specific EEG-fMRI correlations proved robust for multiple brain regions. However, no consistent change in the EEG-BOLD correlations was identified that would correspond to the neuronal maturation captured by the EEG. This result indicates that the EEG-BOLD correlation measures a distinct aspect of neurophysiological activity that presumably matures earlier, since it is less sensitive to late maturation than the neuronal activity captured by low-frequency EEG.},
	number = {3},
	urldate = {2015-04-10},
	journal = {NeuroImage},
	author = {Lüchinger, Rafael and Michels, Lars and Martin, Ernst and Brandeis, Daniel},
	month = jun,
	year = {2011},
	pmid = {21349336},
	keywords = {Adolescent, Adult, Aging, Aging: physiology, Alpha Rhythm, Alpha Rhythm: physiology, Brain, Brain: growth \& development, Data Interpretation, Delta Rhythm, Delta Rhythm: physiology, Electroencephalography, Female, Humans, Magnetic Resonance Imaging, Male, Models, Nerve Net, Nerve Net: growth \& development, Nerve Net: physiology, Neurological, Oxygen, Oxygen: blood, Photic Stimulation, Regression Analysis, Rest, Rest: physiology, Statistical, Theta Rhythm, Theta Rhythm: physiology, Young Adult},
	pages = {1493--1505},
}

@article{kelly_london_2011,
	title = {The {London} low emission zone baseline study},
	issn = {1041-5505},
	abstract = {On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter {\textless} or = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these suggested that the clearest signals of change were most likely to be measured near roadsides. The seven key areas were also likely to be of importance in carrying out a study to assess the health outcomes of an air quality intervention like the LEZ. Of the seven key areas, two already had monitoring sites with a full complement of equipment, four had monitoring sites that required upgrades of existing equipment, and one required a completely new installation. With the upgrades and new installations in place, fully ratified (verified) pollutant data (for PM10, PM with an aerodynamic diameter {\textless} or = 2.5 microm [PM2.5], nitrogen oxides [NOx], and ozone [O3] at all sites as well as for particle number, black smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites) were then collected for analysis. In addition, the seven key monitoring sites were supported by other sites in the London Air Quality Network (LAQN). From these, a robust set of baseline air quality data was produced. Data from automatic and manual traffic counters as well as automatic license-plate recognition cameras were used to compile detailed vehicle profiles. This enabled us to establish more precise associations between ambient pollutant concentrations and vehicle emissions. An additional goal of the study was to collect baseline PM data in order to test the hypothesis that changes in traffic densities and vehicle mixes caused by the LEZ would affect the oxidative potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM data set was the first to describe, in detail, the oxidative potential and metal content of the PM10 and PM2.5 of a major city's airshed. PM in London has considerable oxidative potential; clear differences in this measure were found from site to site, with evidence that the oxidative potential of both PM10 and PM2.5 at roadside monitoring sites was higher than at urban background locations. In the PM10 samples this increased oxidative activity appeared to be associated with increased concentrations of copper (Cu), barium (Ba), and bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. In the PM2.5 samples, no simple association could be seen, suggesting that other unmeasured components were driving the increased oxidative potential in this fraction of the roadside samples. These data suggest that two components were contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10 microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived for this baseline study confirmed key observations from a more limited spatial mapping exercise published in our earlier HEI report on the introduction of the London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In addition, the data set in the current report provided robust baseline information on the oxidative potential and metal content of PM found in the London airshed in the period before implementation of the LEZ; the finding that a proportion of the oxidative potential appears in the PM coarse mode and is apparently related to brake wear raises important issues regarding the nature of traffic management schemes. The final goal of this baseline study was to establish the feasibility, in ethical and operational terms, of using the U.K.'s electronic primary-care records to evaluate the effects of the LEZ on human health outcomes. Data on consultations and prescriptions were compiled from a pilot group of general practices (13 distributed across London, with 100,000 patients; 29 situated in the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals were obtained to link individual primary-care records to modeled NOx concentrations by means of post-codes. (To preserve anonymity, the postcodes were removed before delivery to the research team.) A wide range of NOx exposures was found across London as well as within and between the practices examined. Although we observed little association between NOx exposure and smoking status, a positive relationship was found between exposure and increased socioeconomic deprivation. The health outcomes we chose to study were asthma, chronic obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory tract infections, ischemic heart disease, heart failure, and atrial fibrillation. These outcomes were measured as prevalence or incidence. Their distributions by age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord with those reported in the epidemiology literature. No cross-sectional positive associations were found between exposure to NOx and any of the studied health outcomes; some associations were significantly negative. After the pilot study, a suitable primary-care database of London patients was identified, the General Practice Research Database responsible for giving us access to these data agreed to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring privacy of the records was agreed upon. The database included about 350,000 patients who had remained at the same address over the four-year period of the study. Power calculations for a controlled longitudinal analysis were then performed, indicating that for outcomes such as consultations for respiratory illnesses or prescriptions for asthma there was sufficient power to identify a 5\% to 10\% reduction in consultations for patients most exposed to the intervention compared with patients presumed to not be exposed to it. In conclusion, the work undertaken in this study provides a good foundation for future LEZ evaluations. Our extensive monitoring network, measuring a comprehensive set of pollutants (and a range of particle metrics), will continue to provide a valuable tool both for assessing the impact of LEZ regulations on air quality in London and for furthering understanding of the link between PM's composition and toxicity. Finally, we believe that in combination with our modeling of the predicted population-based changes in pollution exposure in London, the use of primary-care databases forms a sound basis and has sufficient statistical power for the evaluation of the potential impact of the LEZ on human health.},
	language = {eng},
	number = {163},
	journal = {Research Report (Health Effects Institute)},
	author = {Kelly, Frank and Armstrong, Ben and Atkinson, Richard and Anderson, H. Ross and Barratt, Ben and Beevers, Sean and Cook, Derek and Green, Dave and Derwent, Dick and Mudway, Ian and Wilkinson, Paul and {HEI Health Review Committee}},
	month = nov,
	year = {2011},
	pmid = {22315924},
	keywords = {Adolescent, Adult, Aged, Air Pollutants, Air Pollution, Child, Child, Preschool, Cross-Sectional Studies, Environmental Exposure, Environmental Monitoring, Female, Health Status, Humans, Infant, London, Longitudinal Studies, Male, Metals, Middle Aged, Nitrogen Oxides, Particulate Matter, Pilot Projects, Primary Health Care, Small-Area Analysis, Smoking, Socioeconomic Factors, Vehicle Emissions, Young Adult},
	pages = {3--79}
}

@article{kotz_incidence_2011,
	title = {Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in {England}, 2001 to 2005},
	volume = {127},
	issn = {1097-6825},
	doi = {10.1016/j.jaci.2010.11.021},
	abstract = {BACKGROUND: Previous descriptions of the epidemiology of peanut allergy have mainly been derived from small cross-sectional studies.
OBJECTIVE: To interrogate a large national research database to provide estimates for the incidence, prevalence, and trends of general practitioner (GP)-recorded diagnosis of peanut allergy in the English population.
METHODS: Version 10 of the QRESEARCH database was used with data from 2,958,366 patients who were registered with 422 United Kingdom general practices in the years 2001 to 2005. The primary outcome was a recording of clinician-diagnosed peanut allergy.
RESULTS: The age-sex standardized incidence rate of peanut allergy in 2005 was 0.08 per 1000 person-years (95\% CI, 0.07-0.08), and the prevalence rate was 0.51 per 1000 patients (95\% CI, 0.49-0.54). This translated into an estimated 4000 incident cases (95\% CI, 3500-4600) and 25,700 prevalent cases (95\% CI, 24,400-27,100) of GP-recorded diagnosis of peanut allergy in England in 2005. During the study period, the incidence rate of peanut allergy remained fairly stable, whereas the prevalence rate doubled. In those under 18 years of age, the crude lifetime prevalence rate was higher in males than females. A significant inverse relationship between prevalence and socioeconomic status was found.
CONCLUSION: These data on GP-recorded diagnosis of peanut allergy from a large general practice database suggest a much lower prevalence in peanut allergy than has hitherto been found. This difference may in part be explained by underrecording of peanut allergy in general practice. Further research is needed to assess the true frequency of peanut allergy in the population and whether there has been a true increase in recent years.},
	language = {eng},
	number = {3},
	journal = {The Journal of Allergy and Clinical Immunology},
	author = {Kotz, Daniel and Simpson, Colin R. and Sheikh, Aziz},
	month = mar,
	year = {2011},
	pmid = {21236479},
	keywords = {Adolescent, Adult, Child, Child, Preschool, England, Female, General Practitioners, Great Britain, Humans, Infant, Male, Medical Records, Peanut Hypersensitivity, Prevalence, incidence},
	pages = {623--630.e1}
}

@article{ wicclair_conscientious_2011,
  title = {Conscientious refusals by hospitals and emergency contraception},
  volume = {20},
  issn = {1469-2147},
  doi = {10.1017/S0963180110000691},
  language = {eng},
  number = {1},
  journal = {Cambridge quarterly of healthcare ethics: {CQ}: the international journal of healthcare ethics committees},
  author = {Wicclair, Mark R},
  month = {January},
  year = {2011},
  pmid = {21223617},
  keywords = {Adolescent, Adult, Catholicism, Child Abuse, Sexual, Choice Behavior, Conscience, Contraception, Postcoital, Contraceptives, Postcoital, Emergency Service, Hospital, Female, Humans, Personal Autonomy, Pregnancy, Pregnancy Tests, Prescription Drugs, Rape, Refusal to Treat, Sex Offenses, Young Adult},
  pages = {130--138}
}

@article{pich_patient-related_2011,
	title = {Patient-related violence at triage: {A} qualitative descriptive study.},
	volume = {19},
	issn = {1878-013X},
	abstract = {AIM: The aim of the study was to describe the experiences of a group of triage nurses with patient-related workplace violence during the previous month., BACKGROUND: Globally and within the Australian health industry, nurses have been reported to be the occupation at most risk of patient-related violence, with triage nurses identified as a high risk group for both verbal and physical violence., METHOD: The study took place in the Emergency Department of a tertiary referral and teaching hospital in regional New South Wales, Australia. Data were collected from August to September 2008, and a qualitative descriptive methodology was employed., FINDINGS: The participants all reported experiencing episodes of patient related violence that were perceived as inevitable and increasing in intensity and frequency. Themes included identification of precipitating factors such as long waiting times and alcohol and substance misuse. Organisational issues included lack of aggression minimisation training; lack of formal debriefing following episodes of violence and frustration at lengthy reporting processes., CONCLUSION: In the context of the Emergency Department where patients present with a range of diagnoses and behaviours, it is unlikely that the issue of patient-related violence can be totally eliminated. However it can be prevented or managed more effectively on many occasions. Strategies to support staff and prevent and manage violence effectively should be a priority to provide a safe working environment and occupational health and safety for staff. Copyright  2009 Elsevier Ltd. All rights reserved.},
	number = {1},
	journal = {International emergency nursing},
	author = {Pich, Jacqueline and Hazelton, Michael and Sundin, Deborah and Kable, Ashley},
	year = {2011},
	keywords = {*Emergency Nursing, *Nurse-Patient Relations, *Nursing Staff, Hospital/px [Psychology], *Occupational Exposure/sn [Statistics \& Numerical Data], *Triage, *Violence/sn [Statistics \& Numerical Data], Adult, Attitude of health personnel, Emergency Nursing/og [Organization \& Administration], Female, Hospitals, Public, Hospitals, Teaching, Male, Middle Aged, New South Wales, Nursing Methodology Research, Nursing Staff, Hospital/og [Organization \& Administration], Occupational Health/sn [Statistics \& Numerical Data], Qualitative Research, Safety Management, Trauma Centers, Triage/og [Organization \& Administration], Violence/pc [Prevention \& Control], Violence/px [Psychology], Workplace/og [Organization \& Administration], Workplace/px [Psychology], humans},
	pages = {12--9},
}

Paper  abstract   bibtex   

@article{win_influenza_2010,
	title = {Influenza {B} {Outbreak} among influenza-vaccinated welfare home residents in {Singapore}},
	volume = {39},
	issn = {0304-4602},
	url = {http://www.annals.edu.sg/pdf/39VolNo6Jun2010/V39N6p448.pdf http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed11&NEWS=N&AN=359159306},
	abstract = {Introduction: Outbreaks of acute respiratory illness occur commonly in long-term care facilities (LTCF), due to the close proximity of residents. Most influenza outbreak reports have been from temperate countries. This study reports an outbreak of infl uenza B among a highly immunised resident population in a welfare home in tropical Singapore, and discusses vaccine effi cacy and the role of acute respiratory illness surveillance for outbreak prevention and control. Material(s) and Method(s): During the period from 16 to 21 March 2007, outbreak investigations and active case fi nding were carried out among residents and nursing staff at the welfare home. Interviews and medical notes review were conducted to obtain epidemiological and clinical data. Hospitalised patients were tested for respiratory pathogens. Further genetic studies were also carried out on positive respiratory samples. Result(s): The overall clinical attack rate was 9.4\% (17/180) in residents and 6.7\% (2/30) in staff. All infected residents and staff had received infl uenza immunisation. Fifteen residents were hospitalised, with 2 developing severe complications. Genetic sequencing revealed that the outbreak strain had an 8.2\% amino acid difference from B/Malaysia/2506/2004, the 2006 southern hemisphere infl uenza vaccine strain, which the residents and staff had earlier received. Conclusion(s): A mismatch between the vaccine and circulating infl uenza virus strains can result in an outbreak in a highly immunised LTCF resident population. Active surveillance for acute respiratory illness in LTCFs could be implemented for rapid detection of antigenic drift. Enhanced infection control and other preventive measures can then be deployed in a timely manner to mitigate the effect of any outbreaks.},
	language = {English},
	number = {6},
	journal = {Annals of the Academy of Medicine Singapore},
	author = {Win, M. K. and Chow, A. and Chen, M. and Lau, Y. F. and Ooi, E. E. and Leo, Y. S.},
	year = {2010},
	keywords = {*influenza B/dt [Drug Therapy], *influenza B/pc [Prevention], *influenza vaccination, *influenza vaccine/dt [Drug Therapy], Singapore, adult, aged, article, case finding, clinical article, clinical feature, controlled study, disease severity, disease surveillance, drug efficacy, epidemic, gene sequence, hospitalization, human, infection control, influenza B/dt [Drug Therapy], polymerase chain reaction, residential home, strain difference, thorax radiography, virus strain},
	pages = {448--452},
}

@article{hippisley-cox_individualising_2010,
	title = {Individualising the risks of statins in men and women in {England} and {Wales}: population-based cohort study},
	volume = {96},
	issn = {1468-201X},
	shorttitle = {Individualising the risks of statins in men and women in {England} and {Wales}},
	doi = {10.1136/hrt.2010.199034},
	abstract = {OBJECTIVE: To derive and validate risk algorithms so that the risks of four clinical outcomes associated with statin use can be estimated for individual patients.
DESIGN: Prospective open cohort study using routinely collected data from 368 QResearch general practices in England and Wales to develop the scores. The scores were validated using two separate sets of practices-188 separate QResearch practices and 364 practices contributing to the THIN database.
SUBJECTS: In the QResearch derivation cohort 225 922 new users of statins and 1 778 770 non-users of statins were studied. In the QResearch validation cohort 118 372 statin users and 877 812 non-users of statins were studied. In the THIN validation cohort, we studied 282 056 statin users and 1 923 840 non-users of statins were studied.
METHODS: Cox proportional hazards models in the derivation cohort to derive risk equations. Measures of calibration and discrimination in both validation cohorts.
OUTCOMES: 5-Year risk of moderate/serious myopathic events; moderate/serious liver dysfunction; acute renal failure and cataract.
RESULTS: The performance of three of the risk prediction algorithms in the THIN cohort was very good. For example, in women, the algorithm for moderate/serious myopathy explained 42.15\% of the variation. The corresponding D statistics was 1.75. The acute renal failure algorithm explained 59.62\% of the variation (D statistic=2.49). The cataract algorithm explained 59.14\% of the variation (D statistic=2.46). The algorithms to predict moderate/severe liver dysfunction only explained 15.55\% of the variation (D statistics=0.89). The performance of each algorithm was similar for both sexes when tested on the QResearch validation cohort.
CONCLUSIONS: The algorithms to predict acute renal failure, moderate/serious myopathy and cataract could be used to identify patients at increased risk of these adverse effects enabling patients to be monitored more closely. Further research is needed to develop a better algorithm to predict liver dysfunction.},
	language = {eng},
	number = {12},
	journal = {Heart (British Cardiac Society)},
	author = {Hippisley-Cox, Julia and Coupland, Carol},
	month = jun,
	year = {2010},
	pmid = {20489220},
	keywords = {Acute Kidney Injury, Adult, Aged, Aged, 80 and over, Algorithms, Body Mass Index, Cataract, Drug-Induced Liver Injury, England, Epidemiologic Methods, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Muscular Diseases, Wales},
	pages = {939--947}
}

@article{allin_baseline_2009,
	title = {Baseline {C}-reactive protein is associated with incident cancer and survival in patients with cancer},
	volume = {27},
	issn = {1527-7755},
	doi = {10.1200/JCO.2008.19.8440},
	abstract = {PURPOSE: We tested the hypothesis that baseline plasma levels of C-reactive protein (CRP) are associated with risk of incident cancer in the general population and early death in patients with cancer.
PATIENTS AND METHODS: A total of 10,408 individuals from the Danish general population who had CRP measured at baseline were observed for up to 16 years; 1,624 developed cancer, and of these, 998 patients died during follow-up. Follow-up was 100\% complete. We excluded individuals with a cancer diagnosis at baseline.
RESULTS: Baseline CRP levels more than 3 versus less than 1 mg/L were associated with multifactorially adjusted hazard ratios of 1.3 (95\% CI, 1.0 to 1.6) for cancer of any type, 2.2 (95\% CI, 1.0 to 4.6) for lung cancer, 1.9 (95\% CI, 0.8 to 4.6) for colorectal cancer, and 0.7 (95\% CI, 0.4 to 1.4) for breast cancer. Corresponding hazard ratios for the highest versus the lowest quintile of baseline CRP levels were 1.3 (95\% CI, 1.0 to 1.6), 2.1 (95\% CI, 1.2 to 3.8), 1.7 (95\% CI, 0.8 to 3.2), and 0.9 (95\% CI, 0.5 to 1.7), respectively. Multifactorially adjusted hazard ratios for early death in patients with cancer were 1.8 (95\% CI, 1.2 to 2.7) for CRP more than 3 versus less than 1 mg/L and 1.4 (95\% CI, 1.1 to 1.7) for the highest versus the lowest quintile. Elevated CRP levels were associated with early death in patients with cancer having localized disease, but not in those with metastases (interaction; P = .03).
CONCLUSION: Elevated levels of CRP in cancer-free individuals are associated with increased risk of cancer of any type, of lung cancer, and possibly of colorectal cancer. Moreover, elevated levels of baseline CRP associate with early death after a diagnosis of any cancer, particularly in patients without metastases.},
	language = {eng},
	number = {13},
	journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
	author = {Allin, Kristine H. and Bojesen, Stig E. and Nordestgaard, Børge G.},
	month = may,
	year = {2009},
	pmid = {19289618},
	keywords = {Adult, Aged, C-Reactive Protein, Cohort Studies, Female, Humans, Male, Middle Aged, Neoplasms, Prospective Studies},
	pages = {2217--2224},
}

Paper  doi  bibtex   

@article{agosta_apolipoprotein_2009,
	title = {Apolipoprotein {E} epsilon4 is associated with disease-specific effects on brain atrophy in {Alzheimer}'s disease and frontotemporal dementia},
	volume = {106},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19164761},
	doi = {10.1073/pnas.0812697106},
	number = {6},
	journal = {Proc Natl Acad Sci U S A},
	author = {Agosta, F. and Vossel, K.A. and Miller, B.L. and Migliaccio, R. and Bonasera, S.J. and Filippi, M. and Boxer, A.L. and Karydas, A. and Possin, K.L. and Gorno-Tempini, M.L.},
	year = {2009},
	keywords = {\#nosource, Adult, Aged, Aged, 80 and over, Alzheimer Disease/*pathology, Apolipoprotein E4/*genetics, Atrophy, Brain Mapping, Brain/*pathology, Case-Control Studies, Dementia/*pathology, Gene Frequency, Hippocampus/pathology, Humans, Middle Aged, Parietal Lobe/pathology, Prognosis, Temporal Lobe/*pathology},
	pages = {2018--22},
}

@article{setakis_changes_2008,
	title = {Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib},
	volume = {59},
	issn = {0004-3591},
	doi = {10.1002/art.23925},
	abstract = {OBJECTIVE: To evaluate the impact of rofecoxib withdrawal on the characteristics of patients prescribed selective cyclooxygenase 2 (COX-2) inhibitors.
METHODS: The General Practice Research Database was used to identify patients age {\textgreater} or =18 years who were prescribed a selective COX-2 inhibitor. Various patient characteristics were noted at the start of therapy: age, sex, nonsteroidal antiinflammatory drug-related risk factors for upper gastrointestinal (GI) events, and the Framingham risk score for cardiovascular disease. Logistic regression was used to compare patients using selective COX-2 inhibitors before and after September 2004.
RESULT: The study population included 171,645 patients receiving selective COX-2 inhibitors. The number of users substantially increased over time until September 2004 and sharply declined thereafter. Approximately 80\% stopped selective COX-2 inhibitor therapy within 6 months. Patients receiving selective COX-2 inhibitors after September 2004 were younger and included more men compared with those receiving therapy before September 2004. There was no change before and after September 2004 in the proportion of patients with GI risk factors or high Framingham risk scores, after adjustment for age and sex. A correlation was found between presence of GI risk factors and high Framingham risk scores. Only 20\% of patients receiving selective COX-2 inhibitors had GI risk factors but low Framingham risk score, which did not change after September 2004.
CONCLUSION: There was no channeling in the usage of selective COX-2 inhibitors toward patients with a high risk of GI and low risk of cardiovascular disease following the withdrawal of rofecoxib.},
	language = {eng},
	number = {8},
	journal = {Arthritis and Rheumatism},
	author = {Setakis, E. and Leufkens, H. G. M. and van Staa, T. P.},
	month = aug,
	year = {2008},
	pmid = {18668614},
	keywords = {Adolescent, Adult, Aged, Cardiovascular Diseases, Cyclooxygenase 2 Inhibitors, Databases, Factual, Drug Prescriptions, Drug Utilization Review, Female, Gastrointestinal Diseases, Great Britain, Humans, Lactones, Logistic Models, Male, Middle Aged, Rheumatic Diseases, Risk Factors, Sulfones, incidence},
	pages = {1105--1111}
}

Paper  doi  abstract   bibtex   

@article{Hadjikhani2008a,
	title = {Pointing with the eyes: the role of gaze in communicating danger.},
	volume = {68},
	issn = {1090-2147},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2582139&tool=pmcentrez&rendertype=abstract},
	doi = {10.1016/j.bandc.2008.01.008},
	abstract = {Facial expression and direction of gaze are two important sources of social information, and what message each conveys may ultimately depend on how the respective information interacts in the eye of the perceiver. Direct gaze signals an interaction with the observer but averted gaze amounts to "pointing with the eyes", and in combination with a fearful facial expression may signal the presence of environmental danger. We used fMRI to examine how gaze direction influences brain processing of facial expression of fear. The combination of fearful faces and averted gazes activated areas related to gaze shifting (STS, IPS) and fear-processing (amygdala, hypothalamus, pallidum). Additional modulation of activation was observed in motion detection areas, in premotor areas and in the somatosensory cortex, bilaterally. Our results indicate that the direction of gaze prompts a process whereby the brain combines the meaning of the facial expression with the information provided by gaze direction, and in the process computes the behavioral implications for the observer.},
	number = {1},
	urldate = {2013-08-25},
	journal = {Brain and cognition},
	author = {Hadjikhani, Nouchine and Hoge, Rick and Snyder, Josh and de Gelder, Beatrice},
	month = oct,
	year = {2008},
	pmid = {18586370},
	keywords = {\#nosource, Adult, Amygdala, Amygdala: physiology, Analysis of Variance, Brain, Brain: physiology, Cerebral Cortex, Cerebral Cortex: physiology, Dominance, Cerebral, Dominance, Cerebral: physiology, Facial Expression, Fear, Fear: physiology, Female, Fixation, Ocular, Humans, Hypothalamus, Hypothalamus: physiology, Image Processing, Computer-Assisted, Image Processing, Computer-Assisted: methods, Magnetic Resonance Imaging, Magnetic Resonance Imaging: methods, Male, Pattern Recognition, Visual, Pattern Recognition, Visual: physiology, Photic Stimulation, Photic Stimulation: methods, Social Perception, Somatosensory Cortex, Somatosensory Cortex: physiology, Visual Perception, Visual Perception: physiology, Young Adult, cognitiva, humanos},
	pages = {1--8},
}

Paper  abstract   bibtex   

@article{farrant_takayasus_2008,
	title = {Takayasu's arteritis following {Crohn}'s disease in a young woman: any evidence for a common pathogenesis?},
	volume = {14},
	issn = {1007-9327},
	shorttitle = {Takayasu's arteritis following {Crohn}'s disease in a young woman},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/18609696},
	abstract = {Takayasu's arteritis and Crohn's disease are chronic inflammatory diseases of uncertain aetiology. They rarely occur together, with only twenty nine cases of co-existent Takayasu's arteritis and Crohn's disease reported in the literature. In 88\% of these cases, Takayasu's arteritis was diagnosed simultaneously or following a diagnosis of Crohn's disease. We present a case of a young Caucasian medical student, incidentally found to have bilateral carotid bruits on auscultation by a colleague. Magnetic resonance angiography revealed stenoses of the common carotid arteries with established collaterals, and a diagnosis of Type 1 Takayasu's arteritis was made. An 18(F)-fluorodeoxyglucose positron emission tomography scan revealed no active disease. Nine months later, she presented with a short history of abdominal pain, vomiting and abdominal distension. Barium follow-through and computer tomography revealed a terminal ileal stricture and proximal small bowel dilation. An extended right hemicoloectomy was performed and histopathology supported a diagnosis of Crohn's disease. This case report is presented with a particular focus on the temporal relationship between these two disease processes and explores whether their concurrence is more than just co-incidence.},
	number = {25},
	urldate = {2010-08-27},
	journal = {World Journal of Gastroenterology: WJG},
	author = {Farrant, Melissa- A L and Mason, Justin C and Wong, Newton A C S and Longman, Robert J},
	month = jul,
	year = {2008},
	pmid = {18609696},
	keywords = {Adult, Auscultation, Carotid Artery, Common, Colectomy, Collateral Circulation, Crohn Disease, Female, Humans, Incidental Findings, Magnetic Resonance Angiography, Takayasu Arteritis, Tomography, X-Ray Computed, Ultrasonography, Doppler, Color},
	pages = {4087--4090},
}

@article{boussekey_pilot_2008,
	title = {A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock.},
	volume = {34},
	issn = {0342-4642 0342-4642},
	doi = {10.1007/s00134-008-1127-3},
	abstract = {OBJECTIVE: High volume hemofiltration (HVHF) has shown potential benefits in septic animals and a few reports suggested a hemodynamic improvement in humans. However, randomized studies are still lacking. Our goal was to evaluate the hemodynamic effects of HVHF in septic shock patients with acute renal failure (ARF). DESIGN AND SETTING: Prospective randomized study in an intensive care unit (ICU). PATIENTS: Twenty patients with septic shock and ARF. INTERVENTIONS: Patients were randomized to either high volume hemofiltration [HVHF 65 ml/(kg h)] or low volume hemofiltration [LVHF 35 ml/(kg h). Vasopressor dose was adjusted to reach a mean arterial pressure (MAP) {\textgreater} 65 mmHg. MEASUREMENTS AND RESULTS: We performed six hourly measurements of MAP, norepinephrine dose, PaO(2)/FiO(2) and  lactate, and four daily urine output and logistic organ dysfunction (LOD) score.  Baseline characteristics of the two groups were comparable on randomization. Mean norepinephrine dose decreased more rapidly after 24 h of HVHF treatment compared  to LVHF treatment (P = 0.004) whereas lactate and PaO(2)/FiO(2) did not differ between the two treatment groups. During the 4-day follow-up, urine output was slightly increased in the HVHF group (P = 0.059) but the LOD score evolution was  not different. Duration of mechanical ventilation, renal replacement therapy and  ICU length of stay were also comparable. Survival on day 28 was not affected. CONCLUSION: HVHF decreased vasopressor requirement and tended to increase urine output in septic shock patients with renal failure. However, a larger trial is required to confirm our results and perhaps to show a benefit in survival.},
	language = {eng},
	number = {9},
	journal = {Intensive care medicine},
	author = {Boussekey, Nicolas and Chiche, Arnaud and Faure, Karine and Devos, Patrick and Guery, Benoit and d'Escrivan, Thibaud and Georges, Hugues and Leroy, Olivier},
	month = sep,
	year = {2008},
	pmid = {18542921},
	keywords = {Humans, Adult, Female, Aged, Intensive Care Units, Male, Middle Aged, Aged, 80 and over, *Hospital Mortality, Acute Kidney Injury/*complications/*therapy, APACHE, Blood Pressure/drug effects, Hemofiltration/*methods, Norepinephrine/administration \& dosage/*therapeutic use, Respiration, Artificial, Shock, Septic/classification/*complications/*therapy, Vasoconstrictor Agents/administration \& dosage/*therapeutic use},
	pages = {1646--1653}
}

@Article{Franklin2008,
  author   = {A. Franklin and G. V. Drivonikou and L. Bevis and I. R L Davies and P. Kay and T. Regier},
  journal  = {Proc Natl Acad Sci U S A},
  title    = {Categorical perception of color is lateralized to the right hemisphere in infants, but to the left hemisphere in adults.},
  year     = {2008},
  number   = {9},
  pages    = {3221-5},
  volume   = {105},
  abstract = {Both adults and infants are faster at discriminating between two colors
	from different categories than two colors from the same category,
	even when between- and within-category chromatic separation sizes
	are equated. For adults, this categorical perception (CP) is lateralized;
	the category effect is stronger for the right visual field (RVF)-left
	hemisphere (LH) than the left visual field (LVF)-right hemisphere
	(RH). Converging evidence suggests that the LH bias in color CP in
	adults is caused by the influence of lexical color codes in the LH.
	The current study investigates whether prelinguistic color CP is
	also lateralized to the LH by testing 4- to 6-month-old infants.
	A colored target was shown on a differently colored background, and
	time to initiate an eye movement to the target was measured. Target
	background pairs were either from the same or different categories,
	but with equal target-background chromatic separations. Infants were
	faster at initiating an eye movement to targets on different-category
	than same-category backgrounds, but only for targets in the LVF-RH.
	In contrast, adults showed a greater category effect when targets
	were presented to the RVF-LH. These results suggest that whereas
	color CP is stronger in the LH than RH in adults, prelinguistic CP
	in infants is lateralized to the RH. The findings suggest that language-driven
	CP in adults may not build on prelinguistic CP, but that language
	instead imposes its categories on a LH that is not categorically
	prepartitioned.},
  doi      = {10.1073/pnas.0712286105},
  keywords = {Adult, Age Factors, Color Perception, Functional Laterality, Humans, Infant, Language, Reaction Time, Visual Fields, 11163613},
}

Website  abstract   bibtex   

@article{
 title = {Impact of adalimumab treatment on health-related quality of life and other patient-reported outcomes: results from a 16-week randomized controlled trial in patients with moderate to severe plaque psoriasis},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {*Quality of Life/psychology,Adult,Anti-Inflammatory Agents/*administration & dosage/,Antibodies, Monoclonal/*administration & dosage/ad,Antirheumatic Agents/*administration & dosage/adve,Dose-Response Relationship, Drug,Epidemiologic Methods,Female,Health Status,Humans,Male,Methotrexate/*administration & dosage/adverse effe,Psoriasis/*drug therapy/immunology,Treatment Outcome},
 pages = {549-557},
 volume = {158},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18047521},
 edition = {2007/12/01},
 id = {4f1dcea9-d08a-37fa-acac-d56565114e6d},
 created = {2017-06-19T13:43:49.367Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:49.476Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Revicki, D<m:linebreak/>Willian, M K<m:linebreak/>Saurat, J-H<m:linebreak/>Papp, K A<m:linebreak/>Ortonne, J-P<m:linebreak/>Sexton, C<m:linebreak/>Camez, A<m:linebreak/>Multicenter Study<m:linebreak/>Randomized Controlled Trial<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>England<m:linebreak/>The British journal of dermatology<m:linebreak/>Bjd8236<m:linebreak/>Br J Dermatol. 2008 Mar;158(3):549-57. Epub 2007 Nov 28.</m:note>},
 abstract = {BACKGROUND: Health-related quality of life (HRQOL) and other patient-reported outcomes (PROs) are important in evaluating the impact of psoriasis and its treatment. OBJECTIVES: To assess the impact of adalimumab treatment on HRQOL and other PROs in patients with moderate to severe psoriasis. METHODS: A 16-week, double-blind, double-dummy, randomized controlled trial evaluated the efficacy and safety of adalimumab in 271 adults with moderate to severe chronic plaque psoriasis. Patients were randomized in a 2:2:1 ratio to adalimumab, methotrexate (MTX) or placebo. PROs were evaluated throughout the study and included the Dermatology Life Quality Index (DLQI), Patient's Global Assessment of disease severity, plaque psoriasis and psoriatic arthritis pain visual analogue scale (VAS), Psoriasis-Related Pruritus Assessment and EuroQOL 5D (EQ-5D). RESULTS: Statistically significant differences were observed between the adalimumab- and placebo-treated and the MTX-treated groups on mean DLQI total scores during the 16-week double-blind study (both P<0.001). Significant differences, favouring adalimumab compared with placebo, were also observed on the Patient's Global Assessment of disease severity (P<0.001), VAS for pain (P<0.001), Psoriasis-Related Pruritus Assessment (P<0.001), EQ-5D VAS (P<0.001) and EQ-5D index score (P<0.01). Compared with MTX, adalimumab resulted in statistically significantly greater improvements in the Patient's Global Assessment of disease severity (P<0.001), the VAS for pain (P<0.01) and the Psoriasis-Related Pruritus Assessment (P<0.001). CONCLUSIONS: Adalimumab was efficacious in improving dermatology-specific HRQOL, disease control and symptom outcomes in patients with moderate to severe psoriasis.},
 bibtype = {article},
 author = {Revicki, D and Willian, M K and Saurat, J H and Papp, K A and Ortonne, J P and Sexton, C and Camez, A},
 journal = {Br J Dermatol},
 number = {3}
}

@Article{Elliot2007,
  author   = {Andrew J Elliot and Markus A Maier and Arlen C Moller and Ron Friedman and J\"org Meinhardt},
  journal  = {J Exp Psychol Gen},
  title    = {Color and psychological functioning: the effect of red on performance attainment.},
  year     = {2007},
  number   = {1},
  pages    = {154-68},
  volume   = {136},
  abstract = {This research focuses on the relation between color and psychological
	functioning, specifically, that between red and performance attainment.
	Red is hypothesized to impair performance on achievement tasks, because
	red is associated with the danger of failure in achievement contexts
	and evokes avoidance motivation. Four experiments demonstrate that
	the brief perception of red prior to an important test (e.g., an
	IQ test) impairs performance, and this effect appears to take place
	outside of participants' conscious awareness. Two further experiments
	establish the link between red and avoidance motivation as indicated
	by behavioral (i.e., task choice) and psychophysiological (i.e.,
	cortical activation) measures. The findings suggest that care must
	be taken in how red is used in achievement contexts and illustrate
	how color can act as a subtle environmental cue that has important
	influences on behavior.},
  doi      = {10.1037/0096-3445.136.1.154},
  keywords = {Achievement, Adolescent, Adult, Color Perception, Escape Reaction, Female, Humans, Male, Psychology, 17324089},
}

Website  abstract   bibtex   

@article{
 title = {No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Adult,Apolipoproteins E/*genetics,Cell Adhesion Molecules/*genetics,Disease Progression,Female,Gene Frequency,Genotype,Humans,Male,Middle Aged,Multiple Sclerosis/*genetics/physiopathology,Severity of Illness Index},
 pages = {156-160},
 volume = {186},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17376543},
 edition = {2007/03/23},
 id = {97823616-1f4d-37f6-a788-8ec55f360a74},
 created = {2017-06-19T13:43:25.441Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:25.558Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Ramagopalan, S V<m:linebreak/>Deluca, G C<m:linebreak/>Morrison, K M<m:linebreak/>Herrera, B M<m:linebreak/>Dyment, D A<m:linebreak/>Orton, S<m:linebreak/>Bihoreau, M T<m:linebreak/>Degenhardt, A<m:linebreak/>Pugliatti, M<m:linebreak/>Sadovnick, A D<m:linebreak/>Sotgiu, S<m:linebreak/>Ebers, G C<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>Netherlands<m:linebreak/>Journal of neuroimmunology<m:linebreak/>S0165-5728(07)00061-6<m:linebreak/>J Neuroimmunol. 2007 May;186(1-2):156-60. Epub 2007 Mar 21.</m:note>},
 abstract = {Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. Apolipoprotein E (APOE) is involved in neuronal remodelling and several studies have attempted to examine the effect of APOE on MS disease severity, but its function in modifying the course of MS is controversial. It has been suggested recently that PVRL2, not APOE, is the locus on chromosome 19 which influences clinical outcome of MS. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of APOE and PVRL2 on MS disease severity. The MS cases selected represent the prognostic best 5% (benign MS) and worst 5% (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that APOE or PVRL2 have any outcome modifying activity. We conclude that APOE and PVRL2 have little or no effect on the clinical outcome of MS.},
 bibtype = {article},
 author = {Ramagopalan, S V and Deluca, G C and Morrison, K M and Herrera, B M and Dyment, D A and Orton, S and Bihoreau, M T and Degenhardt, A and Pugliatti, M and Sadovnick, A D and Sotgiu, S and Ebers, G C},
 journal = {J Neuroimmunol},
 number = {1-2}
}

@article{gentilini_is_2007,
	title = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours? {Lessons} from a series in a single institution},
	volume = {18},
	issn = {0923-7534},
	shorttitle = {Is avoiding post-mastectomy radiotherapy justified for patients with four or more involved axillary nodes and endocrine-responsive tumours?},
	doi = {10.1093/annonc/mdm182},
	abstract = {BACKGROUND: Current guidelines for post-mastectomy radiotherapy (PMRT) derive largely from extrapolating information from multicentre trials. The aim of this study was to describe outcomes of patients who underwent mastectomy without radiotherapy in a single institution.
PATIENTS AND METHODS: 650 patients had total mastectomy and axillary dissection without PMRT between 1997 and 2001. Median follow-up was 65 months.
RESULTS: 5-year cumulative incidence of loco-regional recurrence (LRR) was 6.8\% (3.0, 8.1, 9.9\% in node negative, 1-3, {\textgreater} or =4 positive nodes, respectively). At the multivariate analysis, positive lymph nodes and endocrine non-responsive tumours were found to shorten LRR disease-free survival. In patients with positive hormone receptors, 5-year cumulative incidence of LRR disease-free survival were 2.3\%, 7.6\% and 7.6\% for node negative, 1-3 and {\textgreater} or =4 positive lymph nodes, respectively. The same figures were 5.9\%, 10.3\% and 20.0\% in patients with endocrine non-responsive tumours.
CONCLUSIONS: patients with endocrine-responsive tumours treated by mastectomy and complete (level III) axillary dissection have a low risk of LRR even if four or more positive lymph nodes are involved, thus giving rise to doubts on the use of PMRT in this subset of patients. On the other hand, PMRT might play a role for patients with negative hormone receptors and four or more positive nodes.},
	language = {eng},
	number = {8},
	journal = {Annals of oncology: official journal of the European Society for Medical Oncology / ESMO},
	author = {Gentilini, O and Botteri, E and Rotmensz, N and Intra, M and Gatti, G and Silva, L and Peradze, N and Sahium, R C and Gil, L B and Luini, A and Veronesi, P and Galimberti, V and Gandini, S and Goldhirsh, A and Veronesi, U},
	month = aug,
	year = {2007},
	pmid = {17693648},
	keywords = {Adult, Axilla, Breast Neoplasms, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Lymph Node Excision, mastectomy, Middle Aged, Neoplasm Recurrence, Local, Radiotherapy, Adjuvant, Retrospective Studies, Treatment Outcome},
	pages = {1342--1347},
	file = {Ann Oncol-2007-Gentilini-1342-7.pdf:files/46589/Ann Oncol-2007-Gentilini-1342-7.pdf:application/pdf}
}

Paper  abstract   bibtex   

@article{
 id = {73730010-1674-38ad-8259-0a001e478b75},
 title = {Pre-eclampsia and nasal CPAP: part 2. Hypertension during pregnancy, chronic snoring, and early nasal CPAP intervention.},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Adult,Blood Pressure,Female,Humans,Polysomnography,Positive-Pressure Respiration,Positive-Pressure Respiration: methods,Pre-Eclampsia,Pre-Eclampsia: prevention & control,Pregnancy,Pregnancy Complications,Pregnancy Complications: prevention & control,Pregnancy Outcome,Prenatal Care,Prenatal Care: methods,Severity of Illness Index,Snoring,Snoring: prevention & control,Treatment Outcome,Women's Health},
 created = {2011-08-10T17:12:30.000Z},
 pages = {15-21},
 volume = {9},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/17644475},
 month = {12},
 accessed = {2011-08-10},
 file_attached = {true},
 profile_id = {6d353feb-efe4-367e-84a2-0815eb9ca878},
 group_id = {33f3e9ff-c95c-3e78-a54c-546e54c036da},
 last_modified = {2013-07-09T23:57:26.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Poyares2007},
 client_data = {"desktop_id":"65e3611f-d83d-4974-9542-3b3d33648568"},
 abstract = {To evaluate the potential benefit of nasal continuous positive airway pressure (CPAP) administration in pregnant women recognized to have hypertension early in pregnancy.},
 bibtype = {article},
 author = {Poyares, Dalva and Guilleminault, Christian and Hachul, Helena and Fujita, Luciane and Takaoka, Shanon and Tufik, Sergio and Sass, Nelson},
 journal = {Sleep medicine},
 number = {1}
}

@article{
 title = {Prefrontal regions orchestrate suppression of emotional memories via a two-phase process.},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Adult,Amygdala,Amygdala: physiology,Brain Mapping,Cognition,Cues,Emotions,Female,Frontal Lobe,Frontal Lobe: physiology,Hippocampus,Hippocampus: physiology,Humans,Magnetic Resonance Imaging,Male,Memory,Mental Recall,Prefrontal Cortex,Prefrontal Cortex: physiology,Pulvinar,Pulvinar: physiology,Repression, Psychology,Thinking,Visual Cortex,Visual Cortex: physiology},
 id = {e6052fbc-1b5a-343a-9182-d149433f5b27},
 created = {2016-01-05T19:45:07.000Z},
 file_attached = {false},
 profile_id = {50a856f4-e41b-3395-a32c-35f3a97eb9f9},
 group_id = {41f9b5d2-912d-3281-b756-e2d6e7ccfec5},
 last_modified = {2016-01-05T19:45:07.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 abstract = {Whether memories can be suppressed has been a controversial issue in psychology and cognitive neuroscience for decades. We found evidence that emotional memories are suppressed via two time-differentiated neural mechanisms: (i) an initial suppression by the right inferior frontal gyrus over regions supporting sensory components of the memory representation (visual cortex, thalamus), followed by (ii) right medial frontal gyrus control over regions supporting multimodal and emotional components of the memory representation (hippocampus, amygdala), both of which are influenced by fronto-polar regions. These results indicate that memory suppression does occur and, at least in nonpsychiatric populations, is under the control of prefrontal regions.},
 bibtype = {article},
 author = {Depue, Brendan E and Curran, Tim and Banich, Marie T},
 journal = {Science (New York, N.Y.)}
}

@article{fox_prevalence_2006,
	title = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database: {A} series of retrospective analyses of data from 1998 through 2002},
	volume = {28},
	issn = {0149-2918},
	shorttitle = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database},
	doi = {10.1016/j.clinthera.2006.03.005},
	abstract = {BACKGROUND: Since the mid-1990s, the development of new oral antidiabetic agents (OAs) and treatment guidelines have created an opportunity to improve glycemic control in patients with type 2 diabetes.
OBJECTIVES: This study aimed to assess the prevalence of good and inadequate glycemic control across a 5-year period among patients with diabetes in the United Kingdom. It also investigated the factors associated with achieving glycemic targets.
METHODS: This was a retrospective, cross-sectional analysis of data from the General Practice Research Database. Three limits were used to assess glycosylated hemoglobin (HbA1c): 6.5\%, 7.0\%, or 7.5\%. Values above the cutoffs indicated inadequate control of HbA1c; those at or below the cutoffs indicated good control. The study evaluated clinical and pharmacy data from the years 1998 to 2002 for patients with type 2 diabetes, {\textgreater} or =2 years of follow-up, and {\textgreater} or =2 HbA1c measurements during the first year. Five independent cross-sectional analyses were conducted, grouping data by year. Statistical significance was determined by Student t and chi2 tests.
RESULTS: Data were analyzed for 10,663 patients aged 17 to 98 years. The number of total eligible type 2 diabetes patients increased over the course of the study period: 5674 patients in 1998, 6553 in 1999, 7314 in 2000, 7323 in 2001, and 6192 in 2002. Overall, the study population had a mean (SD) age of 66 (11.0) years, was 53\% male (3033/5674), and had a body mass index of 29 kg/m(2). Seventy-six percent of patients had HbA1c {\textgreater}7.0\% and 37\% were taking {\textgreater} or =2 oral agents. In 1998 and 2002, 79\% (4482/5674) and 76\% (4732/6192) of patients, respectively, had inadequate glycemic control, defined as HbA1c {\textgreater}7.0\%. When defined as HbA1c {\textgreater}7.5\%, 69\% (3923/5674) and 62\% (3814/6192) of patients, respectively, had inadequate control. Finally, when defined as HbA1c {\textgreater}6.5\%, 88\% (5011/5674) of patients in both 1998 and 2002 had inadequate control. Compared with patients with good disease control (HbA1c {\textless} or =7.0\%), patients with inadequate control were approximately 2 years younger (P {\textless} 0.001) and had been prescribed more OAs: 41\% received {\textgreater} or =2 OAs in 1998 and 52\% in 2002, compared with 23\% and 34\% (both, P = 0.001), respectively, of patients with good glycemic control (P {\textless} 0.02). Sex, number of diabetes complications, and number of comorbidities did not differ between groups (P = NS).
CONCLUSIONS: Despite the introduction of new OAs and treatment guidelines, the prevalence of inadequate glycemic control remains high ({\textgreater}60\%) in patients with type 2 diabetes in the United Kingdom. Regardless of the HbA1c cutoff, patients with inadequate control were younger and received prescriptions for more OAs than patients with good control.},
	language = {eng},
	number = {3},
	journal = {Clinical Therapeutics},
	author = {Fox, Kathleen M. and Gerber Pharmd, Robert A. and Bolinder, Bjorn and Chen, Jack and Kumar, Sanjaya},
	month = mar,
	year = {2006},
	pmid = {16750453},
	keywords = {Administration, Oral, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Family Practice, Female, Great Britain, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Retrospective Studies, databases as topic},
	pages = {388--395}
}

Paper  bibtex   

@article{
 id = {d14cb890-55c2-3ae7-867b-c26ce0888855},
 title = {Deadspace: invasive or not?},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Breath Tests,Breath Tests: methods,Capnography,Carbon Dioxide,Carbon Dioxide: analysis,Humans,Respiratory Dead Space,Respiratory Distress Syndrome, Adult,Respiratory Distress Syndrome, Adult: physiopathol},
 created = {2009-07-23T22:42:16.000Z},
 pages = {4-7},
 volume = {96},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16357115},
 month = {1},
 file_attached = {true},
 profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
 group_id = {f87494e7-529d-3e68-b1f1-0e6d57d138db},
 last_modified = {2014-07-19T19:15:28.000Z},
 read = {false},
 starred = {true},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Drummond2006},
 client_data = {"desktop_id":"3003a2ac-bf9a-4502-9b9f-c80e15e72d57"},
 bibtype = {article},
 author = {Drummond, G B and Fletcher, R},
 journal = {British journal of anaesthesia},
 number = {1}
}

@article{westhoff_tacrolimus_2006,
	title = {Tacrolimus in steroid-resistant and steroid-dependent nephrotic syndrome.},
	volume = {65},
	issn = {0301-0430 0301-0430},
	abstract = {BACKGROUND: Steroid resistance and steroid dependence constitute a major problem  in the treatment of minimal-change disease and focal segmental glomerulosclerosis (FSGS). Cyclophosphamide and cyclosporine are well-established alternative immunomodulating agents, whereas data on FK 506 (tacrolimus) are rare. METHODS: The present work provides data from 10 patients of an open, monocentric, non-randomized, prospective trial. Five patients with steroid-dependent minimal-change nephrotic syndrome, 1 patient with steroid-refractory minimal-change disease and 4 patients with steroid-refractory FSGS were started on tacrolimus at trough levels of 5 10 microg/l. In case of steroid-dependence, prednisolone was tapered off in presence oftacrolimus within one month. RESULTS:  Within 6 months, complete remission was achieved in 5 patients (50\%) and partial  remission in 4 patients (40\%), yielding a final response rate of 90\%. One patient was primarily resistent to tacrolimus (steroid-refractory minimal-change), another patient became secondarily resistant to tacrolimus after an initial remission (steroid-refractory FSGS). Average proteinuria significantly decreased  by 77\% from 9.5 +/- 1.4 - 2.2 +/- 1.1 g/day (p {\textless} 0.01). Serum protein significantly raised from 55.0 +/- 1.9 - 64.6 +/- 1.9 g/l (p {\textless} 0.01). Tacrolimus  induced non-significant increases of blood glucose (4.9 +/- 0.1 - 5.1 +/- 0.2 mmol/l), systolic blood pressure (131.4 +/- 7.1 - 139.0 +/- 7.6 mmHg) and creatinine (93.2 +/- 13.9 103.2 +/- 15.3 mmol/l). Five patients have been tapered off tacrolimus so far, nephrotic syndrome relapsed in 4 of them (80\%). Relapse occurred at tacrolimus levels between 2.6 and 6.9 ng/ml. CONCLUSIONS: Our data suggest that tacrolimus may be a promising alternative to cyclosporine both in steroid-resistant and steroid-dependent nephrotic syndrome.},
	language = {eng},
	number = {6},
	journal = {Clinical nephrology},
	author = {Westhoff, T. H. and Schmidt, S. and Zidek, W. and Beige, J. and van der Giet, M.},
	month = jun,
	year = {2006},
	pmid = {16792133},
	keywords = {Adult, Blood Glucose/analysis, Blood Pressure/drug effects, Blood Proteins/analysis, Creatinine/urine, Drug Resistance, Drug Therapy, Combination, Female, Glomerulosclerosis, Focal Segmental/drug therapy, Humans, Male, Middle Aged, Nephrosis, Lipoid/drug therapy, Nephrotic Syndrome/*drug therapy, Prednisolone/therapeutic use, Proteinuria/drug therapy, Steroids/pharmacology/*therapeutic use, Tacrolimus/*therapeutic use},
	pages = {393--400}
}

@article{werbrouck_no_2006,
	title = {No difference in cycle pregnancy rate and in cumulative live-birth rate between women with surgically treated minimal to mild endometriosis and women with unexplained infertility after controlled ovarian hyperstimulation and intrauterine insemination},
	volume = {86},
	issn = {1556-5653},
	doi = {10.1016/j.fertnstert.2006.01.044},
	abstract = {OBJECTIVE: The association between infertility and minimal to mild endometriosis is controversial and poorly understood. The clinical pregnancy rate (PR) per cycle after controlled ovarian hyperstimulation (COH) with or without intrauterine insemination (IUI) is reportedly lower in women with surgically untreated minimal to mild endometriosis than in women with unexplained infertility. It is possible that prior laparoscopic removal of endometriosis has a positive effect on the clinical PR after COH and IUI. Therefore, we tested the hypothesis that after COH and IUI the PR per cycle and the cumulative live-birth rate (CLBR) are equal or higher in women with recently surgically treated minimal to mild endometriosis when compared with women with unexplained infertility.
DESIGN: A retrospective, controlled cohort study.
SETTING: Leuven University Fertility Centre, a tertiary academic referral center.
PATIENT(S): One hundred seven women treated during 259 cycles with COH and IUI including patients with endometriosis (n = 58, 137 cycles) and unexplained infertility (n = 49, 122 cycles). All patients with endometriosis had minimal (n = 41, 100 cycles) or mild (n = 17, 37 cycles) disease that had been laparoscopically removed within 7 months before the onset of treatment with COH and IUI.
INTERVENTION(S): Controlled ovarian hyperstimulation using clomiphene citrate (23 cycles) or gonadotrophins (236 cycles) in combination with IUI.
MAIN OUTCOME MEASURE(S): Clinical PR per cycle and CLBR within four cycles of treatment with COH and IUI.
RESULT(S): The clinical PR per cycle was comparable in women with minimal or mild endometriosis (21\% or 18.9\%, respectively) and in women with unexplained infertility (20.5\%). The CLBR within four cycles of COH and IUI was also comparable in women with minimal endometriosis, mild endometriosis, and unexplained infertility (70.2\%, 68.2 \%, 66.5\%, respectively).
CONCLUSION(S): The data from our study suggest that COH and IUI shortly after laparoscopic excision of endometriosis is as effective as COH and IUI in patients with unexplained subfertility.},
	language = {eng},
	number = {3},
	journal = {Fertility and Sterility},
	author = {Werbrouck, Erika and Spiessens, Carl and Meuleman, Christel and D'Hooghe, Thomas},
	month = sep,
	year = {2006},
	pmid = {16952506},
	keywords = {Adult, Comorbidity, Endometriosis, Female, Humans, Infertility, Insemination, Artificial, Laparoscopy, Live Birth, Menstrual Cycle, Ovulation Induction, Pregnancy, Pregnancy Rate, Prevalence, Prognosis, Retrospective Studies, Treatment Outcome},
	pages = {566--571}
}

@article{frank_effects_2005,
	title = {Effects of compulsory treatment orders on time to hospital readmission},
	volume = {56},
	issn = {1075-2730},
	doi = {10.1176/appi.ps.56.7.867},
	abstract = {To evaluate the effect of compulsory community treatment orders on subsequent time out of the hospital, the authors studied the admission dates of psychotic patients who had repeated hospitalizations in Quebec, Canada, and divided each admission according to its time in relation to the index admission, during which the judicial order was obtained. The data were stratified by type of admission (early, preindex, index, or postindex), and the hypothesis tested was that the median time to readmission would be greatest for the index admission. The hypothesis was confirmed, supporting previous findings that judicial orders that mandate severely ill psychotic patients to undergo compulsory community treatment are associated with decreased time spent in the hospital and thus increased personal freedom.},
	language = {eng},
	number = {7},
	journal = {Psychiatric Services (Washington, D.C.)},
	author = {Frank, Daniel and Perry, J. Christopher and Kean, Dana and Sigman, Maxine and Geagea, Khalil},
	month = jul,
	year = {2005},
	pmid = {16020822},
	keywords = {Adult, Aged, Aged, 80 and over, Commitment of Mentally Ill, Community Mental Health Services, Female, Follow-Up Studies, Hospitalization, Humans, Male, Mental Disorders, Middle Aged, Patient Admission, Quebec, Time Factors, Treatment Outcome},
	pages = {867--869},
}

Paper  doi  abstract   bibtex   

@article{mazard_neural_2005,
	title = {Neural impact of the semantic content of visual mental images and visual percepts},
	volume = {24},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16099355},
	doi = {10/cwgtzc},
	abstract = {The existence of hemispheric lateralization of visual mental imagery remains controversial. In light of the literature, we used fMRI to test whether processing of mental images of object drawings preferentially engages the left hemisphere to compared non-object drawings. An equivalent comparison was also made while participants actually perceived object and non-object drawings. Although these two conditions engaged both hemispheres, activation was significantly stronger in the left occipito-temporo-frontal network during mental inspection of object than of non-object drawings. This network was also activated when perception of object drawings was compared to that of non-object drawings. An interaction was nonetheless observed: this effect was stronger during imagery than during perception in the left inferior frontal and the left inferior temporal gyrus. Although the tasks subjects performed did not explicitly require semantic analysis, activation of this network probably reflected, at least in part, a semantic and possibly a verbal retrieval component when object drawings were processed. Mental imagery tasks elicited activation of early visual cortex at a lower level than perception tasks. In the context of the imagery debate, these findings indicate that, as previously suggested, figurative imagery could involve primary visual cortex and adjacent areas.},
	number = {3},
	journal = {Brain Res Cogn Brain Res},
	author = {Mazard, A. and Laou, L. and Joliot, M. and Mellet, E.},
	year = {2005},
	keywords = {\#nosource, Adolescent, Adult, Cerebral Cortex/*physiology, Data Interpretation, Statistical, Female, Functional Laterality/physiology, Humans, Image Processing, Computer-Assisted, Imagination/*physiology, Learning/physiology, Magnetic Resonance Imaging, Male, Memory/*physiology, Nerve Net/physiology, Photic Stimulation, Semantics, Visual Cortex/physiology, Visual Perception/*physiology},
	pages = {423--35},
}

@Article{Szenkovits2005,
  author   = {Gayaneh Szenkovits and Franck Ramus},
  journal  = {Dyslexia},
  title    = {Exploring dyslexics' phonological deficit {I}: lexical vs sub-lexical and input vs output processes.},
  year     = {2005},
  number   = {4},
  pages    = {253-68},
  volume   = {11},
  abstract = {We report a series of experiments designed to explore the locus of
	the phonological deficit in dyslexia. Phonological processing of
	dyslexic adults is compared to that of age- and IQ-matched controls.
	Dyslexics' impaired performance on tasks involving nonwords suggests
	that sub-lexical phonological representations are deficient. Contrasting
	nonword repetition vs auditory nonword discrimination suggests that
	dyslexics are specifically impaired in input phonological processing.
	These data are compatible with the hypothesis that the deficit initially
	affects input sub-lexical processes, and further spreads to output
	and lexical processes in the course of language acquisition. Further
	longitudinal research is required to confirm this scenario as well
	as to tease apart the role of the quality of phonological representations
	from that of verbal short-term memory processes.},
  keywords = {Adult, Dyslexia, Female, Humans, Male, Memory, Phonetics, Vocabulary, 16355747},
}

Paper  doi  bibtex   

@article{vuilleumier_cognitive_2005,
	title = {Cognitive science: staring fear in the face},
	volume = {433},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15635392},
	doi = {10/cj5nks},
	number = {7021},
	journal = {Nature},
	author = {Vuilleumier, P.},
	year = {2005},
	keywords = {\#nosource, *Facial Expression, Adult, Amygdala/*injuries/*physiopathology, Cues, Discrimination Learning/*physiology, Emotions/physiology, Eye, Face/physiology, Fear/*physiology, Female, Fixation, Ocular/physiology, Humans, Male, Photic Stimulation},
	pages = {22--3},
}

Paper  doi  abstract   bibtex   

@article{cherry_defining_2005,
	title = {Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives},
	volume = {24},
	issn = {0891-3668},
	shorttitle = {Defining pertussis epidemiology},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15876920},
	doi = {00006454-200505001-00005},
	abstract = {In the past decade, numerous sources have noted an increase in reported pertussis in highly immunized populations. This has been accompanied by a perceived change in disease epidemiology, characterized by a significant increase in reported pertussis incidence among adolescents and adults. In populations where children are routinely immunized, adolescents and adults now constitute the main source of infection in infants. However, a range of factors makes delineation of these epidemiologic trends difficult. Reported cases of pertussis represent only a fraction of the actual number of Bordetella pertussis symptomatic infections, because underconsulting, underrecognition and underdiagnosis are widespread and are a particular problem in adolescents and adults. Possible explanations for failure to diagnose pertussis include the heterogeneity in pertussis disease expression and low physician awareness and index of suspicion. Consequently defining pertussis from a clinical perspective is difficult, and this is reflected by a lack of consistency between case definitions. Although case definitions for specific circumstances have been established by the World Health Organization and the United States Centers for Disease Control, these are not universally useful, making intercountry comparisons and global evaluation difficult. Less-than-optimal and poorly performed laboratory tests, or their lack of availability, also make confirmation of B. pertussis infection difficult. To overcome these problems, clinical case definitions should be standardized for outbreak and endemic situations. Rapid, easy-to-use and inexpensive laboratory diagnostic techniques also must be made available and be widely implemented. In particular, polymerase chain reaction and single serum serology are 2 techniques that should be more widely adopted.},
	number = {5 Suppl},
	urldate = {2008-10-01},
	journal = {The Pediatric Infectious Disease Journal},
	author = {Cherry, James D and Grimprel, Emmanuel and Guiso, Nicole and Heininger, Ulrich and Mertsola, Jussi},
	month = may,
	year = {2005},
	pmid = {15876920},
	keywords = {Adolescent, Adult, Age Distribution, Bordetella pertussis, Child, Child, Preschool, Communicable Disease Control, Cough, Diphtheria-Tetanus-Pertussis Vaccine, Disease Notification, Female, Humans, Incidence, Infant, Male, Risk Assessment, Serologic Tests, Sex Distribution, Vaccination, Whooping Cough, World Health, World Health Organization},
	pages = {S25--34},
}

@Article{Backwell2004,
  author   = {Patricia R Y Backwell and Michael D Jennions},
  journal  = {Nature},
  title    = {Animal behaviour: {C}oalition among male fiddler crabs.},
  year     = {2004},
  number   = {6998},
  pages    = {417},
  volume   = {430},
  abstract = {Until now, no compelling evidence has emerged from studies of animal
	territoriality to indicate that a resident will strategically help
	a neighbour to defend its territory against an intruder. We show
	here that territory-owning Australian fiddler crabs will judiciously
	assist other crabs in defending their neighbouring territories. This
	cooperation supports the prediction that it is sometimes less costly
	to assist a familiar neighbour than to renegotiate boundaries with
	a new, and possibly stronger, neighbour.},
  doi      = {10.1038/430417a},
  keywords = {Animals, Attention, Brain, Decision Making, Face, Female, Haplorhini, Housing, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Pattern Recognition, Visual, Photic Stimulation, Prefrontal Cortex, Research Support, Non-U.S. Gov't, U.S. Gov't, P.H.S., Visual Perception, Choice Behavior, Cognition, Dopamine, Learning, Schizophrenia, Substance-Related Disorders, Generalization (Psychology), Motor Skills, Non-P.H.S., Nerve Net, Neuronal Plasticity, Perception, Cerebral Cortex, Memory, Neurons, Sound Localization, Synapses, Synaptic Transmission, Neural Pathways, Non-, Acoustic Stimulation, Adult, Age of Onset, Aging, Blindness, Child, Preschool, Infant, Newborn, Pitch Perception, Analysis of Variance, Animal Welfare, Laboratory, Behavior, Animal, Hybridization, Genetic, Maze Learning, Mice, Inbred C57BL, Inbred DBA, Phenotype, Reproducibility of Results, Darkness, Deafness, Finches, Sleep, Sound, Sunlight, Time Factors, Vocalization, Energy Metabolism, Evolution, Fossils, History, Ancient, Hominidae, Biological, Physical Endurance, Running, Skeleton, Walking, Acoustics, Auditory Perception, Cues, Discrimination Learning, Pair Bond, Social Behavior, Songbirds, Adolescent, England, Habituation (Psychophysiology), Korea, Language, Semantics, Vocabulary, Action Potentials, Hippocampus, Pyramidal Cells, Rats, Rotation, Australia, Brachyura, Cooperative Behavior, Logistic Models, Territoriality, 15269757},
}

Paper  abstract   bibtex   

@article{riva_use_2003,
	title = {The use of the internet in psychological research: comparison of online and offline questionnaires.},
	volume = {6},
	issn = {1094-9313},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/12650565},
	abstract = {The Internet can be an effective medium for the posting, exchange, and collection of information in psychology-related research and data. The relative ease and inexpensiveness of creating and maintaining Web-based applications, associated with the simplicity of use via the graphic-user interface format of form-based surveys, can establish a new research frontier for the social and behavioral sciences. To explore the possible use of Internet tools in psychological research, this study compared Web-based assessment techniques with traditional paper-based methods of different measures of Internet attitudes and behaviors in an Italian sample. The collected data were analyzed to identify both differences between the two samples and in the psychometric characteristics of the questionnaires. Even if we found significant differences between the two samples in the Internet attitudes and behaviors, no relevant differences were found in the psychometric properties of the different questionnaires. This result, similar to the ones previously obtained in Web-based assessments of personality constructs, is even more interesting given the lack of control on the characteristics of the online sample. These finding suggests that, if sampling control and validity assessment is provided, Internet-based questionnaires can be a suitable alternative to more traditional paper-based measures.},
	number = {1},
	urldate = {2012-07-29},
	journal = {Cyberpsychology \& behavior : the impact of the Internet, multimedia and virtual reality on behavior and society},
	author = {Riva, Giuseppe and Teruzzi, Tiziana and Anolli, Luigi},
	month = feb,
	year = {2003},
	keywords = {Adolescent, Adult, Female, Humans, Internet, Male, Psychology, Psychology: instrumentation, Psychometrics, Psychometrics: instrumentation, Questionnaires, Research, Research: instrumentation},
	pages = {73--80},
}

Paper  doi  abstract   bibtex   

@article{dault_does_2003,
	title = {Does articulation contribute to modifications of postural control during dual-task paradigms?},
	volume = {16},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12706223},
	doi = {10/bnt922},
	abstract = {Many studies have been carried out to investigate the attentional resources required for postural control, using a 'dual-task' methodology in which performance on mental and postural control tasks is compared when these are carried out separately and concurrently. Most mental tasks used in these dual-task studies have employed verbal responses. However, changes in respiration during speech production are known to produce changes in postural control. Hence, the goal of this study was to determine whether articulation might contribute to the changes found in postural sway when a spoken mental task is being performed and to determine if the type of postural control measurement might also have an impact on the outcome of the study. Twenty young healthy participants were asked to stand on a force platform while executing secondary tasks that were performed silently or required a verbal response, and that required high or low levels of attention. Vision and postural task difficulty were manipulated. Performance of all tasks produced an increased sway frequency and decreased sway amplitude relative to the no task baseline. However, tasks that required articulation resulted in a more pronounced increase in postural sway frequency and sway path than did the tasks that did not require any articulation. These findings could imply that the addition of a secondary task results in increased stiffness, whereas articulation results in a further increased frequency of sway, which leads to an increase in sway path. We conclude that changes in the various parameters of sway that accompany performance of secondary tasks are complex, and are not always wholly attributable to attentional load, but may also be partly due to the motor requirements of the task, such as those involved in articulation.},
	number = {3},
	journal = {Brain Res Cogn Brain Res},
	author = {Dault, M.C. and Yardley, L. and Frank, J.S.},
	year = {2003},
	keywords = {\#nosource, Adult, Attention/physiology, Heart Rate/physiology, Humans, Movement/*physiology, Musculoskeletal Equilibrium/physiology, Posture/*physiology, Psychomotor Performance/physiology, Respiratory Mechanics/physiology, Vision/physiology},
	pages = {434--40},
}

Paper  abstract   bibtex   

@article{
 title = {A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor.},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {Adult,Chromosomes, Human, Pair 22,Ependymoma,Ependymoma: diagnosis,Ependymoma: genetics,Female,Genes, Neurofibromatosis 2,Germ-Line Mutation,Humans,Loss of Heterozygosity,Male,Microsatellite Repeats,Pedigree,Spinal Neoplasms,Spinal Neoplasms: genetics},
 pages = {598-602},
 volume = {48},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/14566482},
 month = {1},
 id = {27bbabe4-815b-349a-bf02-494ff0fc34a0},
 created = {2014-08-02T22:29:07.000Z},
 accessed = {2014-08-02},
 file_attached = {true},
 profile_id = {be299c88-7105-3a8d-a1cd-3aa95c25e2c4},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T21:45:19.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Familial ependymal tumors are a very rare disease, the pathogenesis of which is unknown. Previous studies indicate an involvement of tumor suppressor genes localized within chromosomal region 22q, whereas details are still unclear. Here we report a non-neurofibromatosis type-2 (non-NF2) Japanese family in which two of the four members are affected with cervical spinal cord ependymoma, and one of the four is affected with schwannoma. Loss of heterozygosity (LOH) studies were carried out searching for common allelic loss at chromosomal region 22q11.2-qtel in two of the affected patients. Our findings support a prediction for existence of a tumor suppressor gene on chromosome 22 especially related to the tumorigenesis of familial ependymal tumors.},
 bibtype = {article},
 author = {Yokota, Takashi and Tachizawa, Takayuki and Fukino, Koichi and Teramoto, Akira and Kouno, Jun and Matsumoto, Koshi and Emi, Mitsuru},
 journal = {Journal of human genetics},
 number = {11}
}

@article{schlienger_use_2002,
	title = {Use of nonsteroidal anti-inflammatory drugs and the risk of first-time acute myocardial infarction},
	volume = {54},
	issn = {0306-5251},
	abstract = {AIMS: Aspirin decreases the risk of clinical manifestations of atherothrombosis. This effect is mainly due to inhibition of platelet aggregation and potentially due to anti-inflammatory properties of aspirin. To evaluate whether use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) may also be associated with a decreased risk of first-time acute myocardial infarction (AMI), we performed a population-based case-control analysis using the United Kingdom-based General Practice Research Database (GPRD) METHODS: We identified first-time AMI-patients free of preexisting diagnosed cardiovascular or metabolic diseases. We compared use of NSAIDs prior to the index date between cases and control patients who were matched to cases on age, gender, practice and calendar time.
RESULTS: A total of 3319 cases ({\textless}or=75 years) with a diagnosis of first-time AMI between 1992 and 1997 and 13139 controls (matched to cases on age, sex, general practice attended, calendar time, years of prior history in the GPRD) were included. Overall, the relative risk estimate of AMI (adjusted for smoking, body mass index, hormone replacement therapy and aspirin) in current NSAID users was 1.17 (95\% CI 0.99, 1.37). Long-term current NSAID use ({\textgreater}or=30 prescriptions) yielded an adjusted odds ratio (OR) of 1.20 (95\% CI 0.94, 1.55). Stratification by age ({\textless}65 years vs{\textgreater}or=65 years) and sex did not materially change the results.
CONCLUSIONS: Our findings indicate that current NSAID exposure in patients free of diagnosed cardiovascular or metabolic conditions predisposing to cardiovascular diseases does not decrease the risk of AMI.},
	language = {eng},
	number = {3},
	journal = {British Journal of Clinical Pharmacology},
	author = {Schlienger, Raymond G. and Jick, Hershel and Meier, Christoph R.},
	month = sep,
	year = {2002},
	pmid = {12236854},
	pmcid = {PMC1874430},
	keywords = {Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Female, Great Britain, Humans, Male, Middle Aged, Myocardial Infarction, Risk Assessment, Risk Factors},
	pages = {327--332}
}

Website  abstract   bibtex   

@article{
 title = {Grounding spatial language in perception: an empirical and computational investigation.},
 type = {article},
 year = {2001},
 identifiers = {[object Object]},
 keywords = {Adult,Discrimination Learning,Female,Humans,Male,Orientation,Pattern Recognition, Visual,Psycholinguistics,Semantics,Space Perception,Verbal Learning},
 pages = {273-98},
 volume = {130},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11409104},
 month = {6},
 id = {f03a3f85-fc38-3a50-8e63-ac6586b9fb9c},
 created = {2017-09-01T15:53:20.987Z},
 accessed = {2016-01-30},
 file_attached = {false},
 profile_id = {80da7853-f7b7-36a9-8e4c-d7ddb2d9e538},
 group_id = {a2333ea3-15a4-3d40-8d36-f0d9590ca926},
 last_modified = {2017-09-01T15:53:21.069Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Regier2001},
 abstract = {The present paper grounds the linguistic cdategorization of space in aspects of visual perception; specifically, the structure of projective spatial terms such as above are grounded in the process of attention and in vector-sum coding of overall direction. This is formalized in the attentional vector-sum (AVS) model. This computational model accurately predicts linguistic acceptability judgments for spatial terms, under a variety of spatial configurations. In 7 experiments, the predictions of the AVS model are tested against those of 3 competing models. The results support the AVS model and disconfirm its competitors. The authors conclude that the structure of linguistic spatial categories can be partially explained in terms of independently motivated perceptual processes.},
 bibtype = {article},
 author = {Regier, T and Carlson, L A},
 journal = {Journal of experimental psychology. General},
 number = {2}
}

Paper  doi  abstract   bibtex   

@article{steiniger_perifollicular_2001,
	title = {The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?},
	volume = {159},
	issn = {0002-9440},
	shorttitle = {The perifollicular and marginal zones of the human splenic white pulp},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11485909},
	doi = {10.1016/S0002-9440(10)61722-1},
	abstract = {We investigate the white pulp compartments of 73 human spleens and demonstrate that there are several microanatomical peculiarities in man that do not occur in rats or mice. Humans lack a marginal sinus separating the marginal zone (MZ) from the follicles or the follicular mantle zone. The MZ is divided into an inner and an outer compartment by a special type of fibroblasts. An additional compartment, termed the perifollicular zone, is present between the follicular MZ and the red pulp. The perifollicular zone contains sheathed capillaries and blood-filled spaces without endothelial lining. In the perifollicular zone, in the outer MZ, and in the T cell zone fibroblasts of an unusual phenotype occur. These cells stain for the adhesion molecules MAdCAM-1, VCAM-1 (CD106), and VAP-1; the Thy-1 (CD90) molecule; smooth muscle alpha-actin and smooth muscle myosin; cytokeratin 18; and thrombomodulin (CD141). They are, however, negative for the peripheral node addressin, the cutaneous lymphocyte antigen, CD34, PECAM-1 (CD31), and P- and E-selectin (CD62P and CD62E). In the MZ the fibroblasts are often tightly associated with CD4-positive T lymphocytes, whereas CD8-positive cells are almost absent. Our findings lead to the hypothesis, that recirculating CD4-positive T lymphocytes enter the human splenic white pulp from the open circulation of the perifollicular zone without crossing an endothelium. Specialized fibroblasts may attract these T cells and guide them into the periarteriolar T cell area.},
	number = {2},
	urldate = {2012-03-26},
	journal = {The American Journal of Pathology},
	author = {Steiniger, B and Barth, P and Hellinger, A},
	month = aug,
	year = {2001},
	pmid = {11485909},
	keywords = {Actins, Adult, Animals, Antigens, CD, Biological Markers, Cell Adhesion Molecules, Female, Fibroblasts, Humans, Keratins, Lymphocytes, Male, Mice, Myosins, Rats, Spleen, Splenectomy},
	pages = {501--512},
}

Paper  abstract   bibtex   

@article{krause_effects_2000,
	title = {The effects of memory load on event-related {EEG} desynchronization and synchronization.},
	volume = {111},
	issn = {1388-2457},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11068244},
	abstract = {OBJECTIVES: To examine the effects of working memory load on the event-related desynchronization (ERD) and synchronization (ERS) of several narrow EEG frequency bands.

METHODS: ERD/ERS responses of the 4-6, 6-8, 8-10 and 10-12 Hz EEG frequency bands were studied in 24 normal subjects performing a visual sequential letter task (so-called n-back task) in which memory load was varied from 0 to 2.

RESULTS: In the 4-6 Hz theta frequency band, a long-lasting synchronization was observed in the anterior electrodes, especially after the presentation of targets. In the 6-8 and 8-10 Hz frequency bands, anterior ERS was elicited especially in the 2-back condition (highest memory load). In contrast to the responses of the 8-10 Hz frequency band, in the 10-12 Hz frequency band the 2-back experimental condition elicited the greatest ERD.

CONCLUSIONS: In the highest memory load (2-back) experimental condition the attentional capacities were most probably exceeded, resulting in 6-8 and 8-10 Hz ERS. This might reflect an inhibition of such brain areas (frontal cortices) no longer involved in task completion when alternative strategies are needed and utilized. These more 'cognitive' strategies were then reflected as an increase in 10-12 Hz ERD. Additionally, our results support the assumption that the simultaneously recorded ERD/ERS responses of different narrow EEG frequency bands differ and reflect distinct aspects of information processing.},
	number = {11},
	urldate = {2015-05-08},
	journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
	author = {Krause, C M and Sillanmäki, L and Koivisto, M and Saarela, C and Häggqvist, A and Laine, M and Hämäläinen, H},
	month = nov,
	year = {2000},
	pmid = {11068244},
	keywords = {Adult, Brain, Brain: physiology, Cortical Synchronization, Electroencephalography, Evoked Potentials, Evoked Potentials: physiology, Female, Humans, Male, Memory, Memory: physiology},
	pages = {2071--8},
}

@article{van_staa_oral_2000,
	title = {Oral corticosteroids and fracture risk: relationship to daily and cumulative doses},
	volume = {39},
	issn = {1462-0324},
	shorttitle = {Oral corticosteroids and fracture risk},
	abstract = {OBJECTIVE: This study examined the effects of daily and cumulative oral corticosteroid doses on the risk of fractures.
METHODS: Information was obtained from the General Practice Research Database, which contains medical records of general practitioners in England and Wales. The study included 244 235 oral corticosteroid users and 244 235 controls.
RESULTS: Patients taking higher doses (at least 7. 5 mg daily of prednisolone or equivalent) had significantly increased risks of non-vertebral fracture [relative rate (RR)=1.44, 95\% confidence interval (CI) 1.34-1.54], hip fracture (RR=2.21, 95\% CI 1.85-2.64) and vertebral fracture (RR=2.83, 95\% CI 2.35-2.40) relative to patients using oral corticosteroids at lower doses (less than 2.5 mg per day). Fracture risk was also elevated among people with higher cumulative exposure to oral corticosteroids over the study period, but this effect was almost wholly removed by adjustment for daily dose, age, gender and other confounding variables.
CONCLUSIONS: These findings suggest that the adverse skeletal effects of oral corticosteroids manifest rapidly and are related to daily dose. The level of previous exposure to oral corticosteroids was not a strong determinant of the risk of fracture. Preventive measures against corticosteroid-induced osteoporosis should therefore be instituted as soon after the commencement of glucocorticoid therapy as possible.},
	language = {eng},
	number = {12},
	journal = {Rheumatology (Oxford, England)},
	author = {van Staa, T. P. and Leufkens, H. G. and Abenhaim, L. and Zhang, B. and Cooper, C.},
	month = dec,
	year = {2000},
	pmid = {11136882},
	keywords = {Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Dose-Response Relationship, Drug, Female, Fractures, Bone, Humans, Middle Aged, Osteoporosis, Registries, Risk Factors},
	pages = {1383--1389}
}

Website  abstract   bibtex   

@article{
 title = {Multivariate frailty model with a major gene: application to genealogical data},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {*Genetic Predisposition to Disease,*Models, Genetic,Adolescent,Adult,Alleles,Child,Child, Preschool,Female,Genotype,Humans,Infant,Infant, Newborn,Longevity/*genetics,Male,Mathematical Computing,Multivariate Analysis,Quebec,Risk,Software,Survival Analysis},
 pages = {412-416},
 volume = {77},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11187585},
 id = {23588418-0e3c-33dd-b0e4-fed475556b34},
 created = {2017-06-19T13:44:21.917Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:22.080Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0926-9630<m:linebreak/>Journal Article</m:note>},
 abstract = {Multivariate survival models are shown to be appropriate for the analysis of the genetic and the environmental nature of a human life-span. Models which involve continuously distributed individual frailty, play an important role in the genetic analysis of an individual's susceptibility to disease and death. These models, however, are not appropriate for the detection of the effects of separate genes on survival. For this purpose we developed a 'major gene' frailty model of multivariate survival and applied it to simulated and real pedigree data. The analysis shows that this model can be used for the detection of the presence of major genes in the population and for the evaluation of the effects of such genes on survival.},
 bibtype = {article},
 author = {Begun, A and Desjardins, B and Iachine, I and Yashin, A},
 journal = {Stud Health Technol Inform}
}

@Article{Thoroughman2000,
  author   = {KA Thoroughman and R Shadmehr},
  journal  = {Nature},
  title    = {Learning of action through adaptive combination of motor primitives.},
  year     = {2000},
  number   = {6805},
  pages    = {742-7},
  volume   = {407},
  abstract = {Understanding how the brain constructs movements remains a fundamental
	challenge in neuroscience. The brain may control complex movements
	through flexible combination of motor primitives, where each primitive
	is an element of computation in the sensorimotor map that transforms
	desired limb trajectories into motor commands. Theoretical studies
	have shown that a system's ability to learn action depends on the
	shape of its primitives. Using a time-series analysis of error patterns,
	here we show that humans learn the dynamics of reaching movements
	through a flexible combination of primitives that have gaussian-like
	tuning functions encoding hand velocity. The wide tuning of the inferred
	primitives predicts limitations on the brain's ability to represent
	viscous dynamics. We find close agreement between the predicted limitations
	and the subjects' adaptation to new force fields. The mathematical
	properties of the derived primitives resemble the tuning curves of
	Purkinje cells in the cerebellum. The activity of these cells may
	encode primitives that underlie the learning of dynamics.},
  doi      = {10.1038/35037588},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, 11048700},
}

@article{jick_risk_2000-1,
	title = {Risk of venous thromboembolism among users of third generation oral contraceptives compared with users of oral contraceptives with levonorgestrel before and after 1995: cohort and case-control analysis},
	volume = {321},
	issn = {0959-8138},
	shorttitle = {Risk of venous thromboembolism among users of third generation oral contraceptives compared with users of oral contraceptives with levonorgestrel before and after 1995},
	abstract = {OBJECTIVE: To compare the risk of idiopathic venous thromboembolism among women taking third generation oral contraceptives (with gestodene or desogestrel) with that among women taking oral contraceptives with levonorgestrel.
DESIGN: Cohort and case-control analyses derived from the General Practice Research Database.
SETTING: UK general practices, January 1993 to December 1999.
PARTICIPANTS: Women aged 15-39 taking third generation oral contraceptives or oral contraceptives with levonorgestrel.
MAIN OUTCOME MEASURES: Relative incidence (cohort study) and odds ratios (case-control study) as measures of the relative risk of venous thromboembolism.
RESULTS: The adjusted estimates of relative risk for venous thromboembolism associated with third generation oral contraceptives compared with oral contraceptives with levonorgestrel was 1.9 (95\% confidence interval 1.3 to 2.8) in the cohort analysis and 2.3 (1.3 to 3.9) in the case-control study. The estimates for the two types of oral contraceptives were similar before and after the warning issued by the Committee on Safety of Medicines in October 1995. A shift away from the use of third generation oral contraceptives after the scare was more pronounced among younger women (who have a lower risk of venous thromboembolism) than among older women. Fewer cases of venous thromboembolism occurred in 1996 and later than would have been expected if the use of oral contraceptives had remained unchanged.
CONCLUSIONS: These findings are consistent with previously reported studies, which found that compared with oral contraceptives with levonorgestrel, third generation oral contraceptives are associated with around twice the risk of venous thromboembolism.},
	language = {eng},
	number = {7270},
	journal = {BMJ (Clinical research ed.)},
	author = {Jick, H. and Kaye, J. A. and Vasilakis-Scaramozza, C. and Jick, S. S.},
	month = nov,
	year = {2000},
	pmid = {11073511},
	pmcid = {PMC27524},
	keywords = {Adolescent, Adult, Age Distribution, Body Mass Index, Case-Control Studies, Cohort Studies, Contraceptives, Oral, Contraceptives, Oral, Synthetic, Female, Humans, Levonorgestrel, Odds Ratio, Risk Factors, Smoking, Thromboembolism, Time Factors},
	pages = {1190--1195}
}

Paper  doi  abstract   bibtex   

@article{loeffelholz_comparison_1999,
	title = {Comparison of {PCR}, culture, and direct fluorescent-antibody testing for detection of {Bordetella} pertussis},
	volume = {37},
	issn = {0095-1137},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/10449467},
	doi = {10449467},
	abstract = {We prospectively compared the performance of culture, direct fluorescent-antibody testing (DFA), and an in-house-developed PCR test targeting the repeated insertion sequence IS481 for the detection of Bordetella pertussis in nasopharyngeal swab specimens. We tested 319 consecutive paired specimens on which all three tests were performed. A total of 59 specimens were positive by one or more tests. Of these, 5 were positive by all three tests, 2 were positive by culture and PCR, 16 were positive by PCR and DFA, 28 were positive by PCR only, and 8 were positive by DFA only. Any specimen positive by culture was considered to be a true positive, as were specimens positive by both PCR and DFA. Specimens positive only by PCR or DFA were considered discrepant, and their status was resolved by review of patient histories. Patients with symptoms meeting the Centers for Disease Control and Prevention clinical case definition for pertussis and who had a specimen positive by PCR or DFA were considered to have true B. pertussis infections. Of the 28 patients positive by PCR only, 20 met the clinical case definition for pertussis, while 3 of the 8 patients positive by DFA only met the clinical case definition. After resolution of the status of discrepant specimens, the sensitivity, specificity, positive predictive value, and negative predictive value were 15.2, 100, 100, and 87.5\%, respectively, for culture; 93.5, 97.1, 84.3, and 98.9\%, respectively, for PCR; and 52.2, 98.2, 82.8, and 92.4\%, respectively, for DFA. The actual positive predictive value of PCR was probably greater, as several PCR-positive patients who did not meet the clinical case definition had symptoms consistent with typical or atypical pertussis. PCR is a sensitive and specific method for the detection of B. pertussis.},
	number = {9},
	urldate = {2008-10-01},
	journal = {Journal of Clinical Microbiology},
	author = {Loeffelholz, M J and Thompson, C J and Long, K S and Gilchrist, M J},
	month = sep,
	year = {1999},
	pmid = {10449467},
	keywords = {Adult, Bordetella pertussis, Child, Fluorescent Antibody Technique, Direct, Humans, Nasopharynx, Polymerase Chain Reaction, Prospective Studies, Sensitivity and Specificity},
	pages = {2872--6},
}

@article{mathewson_using_1999,
	title = {Using telemedicine in the treatment of pressure ulcers},
	volume = {45},
	issn = {0889-5899},
	abstract = {Pressure ulcers are dynamic and therefore require frequent assessment and immediate treatment. For many patients who live long distances from rehabilitation hospitals, frequent assessment and immediate treatment are often unavailable. Recent advances during the last two decades have resulted in the development of telemedicine--long-distance delivery of medical education and services to patients. This pilot study reports on a patient enrolled in a telemedicine program during his fifth hospitalization for pressure ulcers in 16 months. Although this is only a single case study, the results suggest the potential efficacy of this new intervention.},
	language = {eng},
	number = {11},
	journal = {Ostomy/Wound Management},
	author = {Mathewson, C. and Adkins, V. K. and Lenyoun, M. A. and Schmidt, A. M. and Jones, M. L.},
	month = nov,
	year = {1999},
	pmid = {10687659},
	note = {Number: 11},
	keywords = {Adult, Community Health Nursing, Home Care Services, Humans, Male, Nurse Clinicians, Nursing Assessment, Pilot Projects, Pressure Ulcer, Rehabilitation Nursing, Spinal Cord Injuries, Telemedicine},
	pages = {58--62},
}

@article{hippisley-cox_are_1998,
	title = {Are spouses of patients with hypertension at increased risk of having hypertension? {A} population-based case-control study},
	volume = {48},
	issn = {0960-1643},
	shorttitle = {Are spouses of patients with hypertension at increased risk of having hypertension?},
	abstract = {BACKGROUND: Studies of couples, who tend to share an environment but are genetically dissimilar, can shed light on the contribution of environmental factors to hypertension. There has been renewed interest in these environmental factors following the re-analysis of the INTERSALT study.
AIM: To determine whether patients whose spouses have hypertension are at increased risk of hypertension, using a population-based case-control study.
METHOD: The total study population consisted of all 3923 patients over 30 years old registered with one general practice. Male cases with hypertension were matched to male controls without hypertension. Female cases with hypertension were matched to female controls without hypertension. The variables were: diagnosed hypertension; having a spouse with diagnosed hypertension; age; sex; weight; height; body-mass index; couple status; diabetes; and systolic and diastolic blood pressure readings.
RESULTS: On multivariate analysis, when age, body-mass index, diabetes, couple status, and having a blood pressure reading were included, men whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted odds ratio (OR) 2.24; 95\% CI 1.77-2.72; P = 0.001). Similarly, on multivariate analysis, women whose spouses had hypertension had a two-fold increased risk of hypertension (adjusted OR = 2.23; 95\% CI 1.75-2.72; P = 0.001). The risk for both male and female subjects persisted after adjustment for other variables. There was a significant correlation between systolic (r = 0.41; P {\textless} 0.0001) and diastolic (r = 0.25; P {\textless} 0.0001) blood pressures between spouse pairs.
CONCLUSION: The independent association between having a spouse with hypertension and increased risk of hypertension supports the view that there are significant environmental factors in the aetiology of hypertension. The finding has implications for the screening and treatment of hypertension in primary care.},
	language = {eng},
	number = {434},
	journal = {The British Journal of General Practice: The Journal of the Royal College of General Practitioners},
	author = {Hippisley-Cox, J. and Pringle, M.},
	month = sep,
	year = {1998},
	pmid = {9830183},
	pmcid = {PMC1313221},
	keywords = {Adult, Analysis of Variance, Case-Control Studies, England, Female, Humans, Hypertension, Male, Risk Assessment, Risk Factors, Rural Health, Spouses},
	pages = {1580--1583}
}

Paper  doi  abstract   bibtex   

@article{coull_differential_1998,
	title = {Differential activation of right superior parietal cortex and intraparietal sulcus by spatial and nonspatial attention},
	volume = {8},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9740760},
	doi = {10.1006/nimg.1998.0354},
	abstract = {Neuropsychological and functional neuroimaging studies have implicated the right posterior parietal cortex (PPC) in human spatial attention. We tested the hypothesis that this area is also involved in nonspatial aspects of attention and working memory using positron emission tomography in healthy volunteers. In an initial experiment, digits were presented in pseudo-random spatial locations, and subjects attended either to locations or digits in order to detect single targets (attention condition) or to sequences of stimuli (working memory (WM) condition). Right superior parietal cortex (BA7) and intraparietal sulcus (IPS) were active during both spatial (locations) and nonspatial (digits) tasks compared to rest, although more so for the former. Additionally, right PPC was activated to an even greater extent during tests of WM than of attention, especially for tests of spatial WM. There were no differences in activation of dorsolateral prefrontal cortex in the spatial versus nonspatial versions of the task, contrary to many previous studies. A follow-up experiment which presented abstract objects in a fixed, central location confirmed that right IPS was active during tests of nonspatial attention and also that this activation is not due to incidental spatial representation of digit stimuli. However, BA7 was not activated by this nonspatial, nondigit attentional task. Overall, these data suggest first that right IPS is recruited for both nonspatial and spatial attention and WM. Second, right BA7 is recruited specifically for spatial (both direct and indirect) forms of attentional processing. Finally, PPC activations in spatial WM tasks are likely to be due to a combination of spatial perception, attention, and WM, rather than to any of these individually.},
	number = {2},
	journal = {Neuroimage},
	author = {Coull, J.T. and Frith, C.D.},
	year = {1998},
	keywords = {\#nosource, *Brain Mapping, Adult, Arousal/physiology, Attention/*physiology, Frontal Lobe/physiology, Humans, Image Processing, Computer-Assisted, Male, Mental Recall/physiology, Orientation/*physiology, Parietal Lobe/*physiology, Pattern Recognition, Visual/*physiology, Research Support, Non-U.S. Gov't, Tomography, Emission-Computed},
	pages = {176--87},
}

@article{
 title = {The twinning rates and epidemiological characteristics of births in southeast Uttar Pradesh, India},
 type = {article},
 year = {1997},
 identifiers = {[object Object]},
 keywords = {Adult,Birth Rate,Female,Human,India/epidemiology,Maternal Age,Parity,Pregnancy,Pregnancy Complications/*epidemiology,Pregnancy, Multiple/*statistics & numerical data,Seasons,Twins, Dizygotic,Twins, Monozygotic,Twins/*statistics & numerical data},
 pages = {47-56},
 volume = {46},
 id = {529933bb-e6ef-3768-86f0-68daccc174e2},
 created = {2017-06-19T13:43:38.550Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:38.682Z},
 tags = {03/11/06},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>Journal Article<m:linebreak/>Twin Study</m:note>},
 abstract = {Birth statistics over a period of 5 years were analyzed to study epidemiological characteristics of twinning in Southeast Uttar Pradesh, India. The data revealed higher incidence of breech twins (11.84% of all cotwins) as compared to breech single births (2.18%). But the perinatal mortality and caesarean section rates were similar in both twin and singleton pregnancies. The cumulative twinning rate over the studied period was 11.70 per 1000 live births. The MZ and DZ twinning rates were estimated respectively as 3.67 and 8.03 per mill. The mean maternal age of sampled mothers was 26.42 years with one standard deviation of 5.30 years. The twinning rate for mothers over 35 years of age was about four times higher than that in mothers younger than 20 years. Incidentally, the twinning rate was the highest at parity four and a non-linear curve could more appropriately be fitted to the series of data. Seasonal variations were observed for both twin and singleton births. The highest frequency of births was observed from August through October. But seasonal index for twinning rate showed a clear bimodal distribution with peaks in April (223) and September (167).},
 bibtype = {article},
 author = {Sharma, K},
 journal = {Acta Genet Med Gemellol (Roma)},
 number = {1}
}

Website  abstract   bibtex   

@article{
 title = {Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group},
 type = {article},
 year = {1996},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Age Distribution,Aged,Aged, 80 and over,Allergens/diagnostic use,Asthma/epidemiology/*genetics,Atlantic Ocean,Bronchoconstrictor Agents/diagnostic use,Child,Child, Preschool,Consanguinity,Female,Forced Expiratory Volume,Founder Effect,Humans,Linkage (Genetics),Male,Methacholine Chloride/diagnostic use,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Sex Distribution,Skin Tests},
 pages = {1902-1906},
 volume = {153},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8665053},
 id = {ba377ad3-36ac-3937-b8d3-44f6b08c99e3},
 created = {2017-06-19T13:44:45.103Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:45.287Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1073-449x<m:linebreak/>Journal Article</m:note>},
 abstract = {Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus increasing the probability of gene localization. We studied the inbred population of the remote island of Tristan da Cunha to document asthma prevalence for the purpose of genetic linkage analysis. Medical histories and skin atopy were determined on 282 islanders, representing 97% of the population, and airway responsiveness was measured in 254; 226 by methacholine challenge (tidal breathing method) and 28 by bronchodilator response (400 micrograms salbutamol aerosol). Blood samples were collected from 275 islanders. Participants ranged in age from 3 to 94 yr. Asthma was defined as increased airway responsiveness (AR+: PC20 < 4 mg/ml or > or = 15% increase in FEV1 postbronchodilator) combined with a positive history (Hx+). Fifty-seven percent of the islanders had at least partial evidence of asthma (Hx+ and/or AR+) and 23% had a definitive diagnosis of asthma (AR+ with Hx+). Overall 47% of the population were atopic, atopy was proportionally higher in asthmatics (74%) than nonasthmatics (32%; p < 0.01). Analysis of the methacholine dose-response curves demonstrated that asthmatics were significantly (p < 0.01) more responsive than those with AR+ only, and nonasthmatics (AR-, Hx-) were more responsive than laboratory control subjects (p < 0.05), suggesting that these islanders may also carry an airway hyperresponsiveness gene. A frequency plot of the percent fall in FEV1 for all Hx- subjects compared with control data suggests a bimodal distribution consistent with a major gene mechanism for airway responsiveness. Genealogy mapping revealed that the islanders are direct descendants of the 15 original settlers, and historical records suggest at least two founders may have been asthmatic. The data confirm previous reports of a high asthma prevalence on Tristan and support the postulate that this prevalence is a result of gene enrichment occurring in isolated populations by virtue of extensive inbreeding and a probable founder effect.},
 bibtype = {article},
 author = {Zamel, N and McClean, P A and Sandell, P R and Siminovitch, K A and Slutsky, A S},
 journal = {Am J Respir Crit Care Med},
 number = {6 Pt 1}
}

@Article{Kitzes1996,
  author   = {LM Kitzes and GS Hollrigel},
  journal  = {Hear Res},
  title    = {Response properties of units in the posterior auditory field deprived of input from the ipsilateral primary auditory cortex.},
  year     = {1996},
  note     = {as cited in \citeNP{Heil1998}},
  number   = {1-2},
  pages    = {120-30},
  volume   = {100},
  abstract = {The influence of the ipsilateral primary auditory field (AI) on the
	response properties of neurons in the posterior auditory field (Field
	P) was examined in three cats anesthetized with sodium pentobarbital.
	Rate/level functions were obtained, by extracellular recording, from
	single units in Field P before (n = 38) and after (n = 50) subpial
	aspiration of AI. The ablations were primarily confined to the medial
	ectosylvian gyrus, although in one case extended into the high-frequency
	portion of the anterior auditory field. Comparisons between the behavior
	of units isolated before and after AI ablation failed to demonstrate
	any changes in the response properties of neurons in Field P attributable
	to the ablation. Nonmonotonic response profiles, first spike latency,
	variability in latency, threshold and maximal discharge rates of
	the units to acoustic stimuli were not significantly altered by the
	AI ablation. These results indicate that the basic response properties
	of neurons in Field P do not depend on input from the ipsilateral
	AI. This suggests that these properties are most likely determined
	by thalamic input or by circuitry within Field P.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, 8922986},
}

@article{adkin_effect_1995,
	title = {The effect of mannitol on the oral bioavailability of cimetidine},
	volume = {84},
	issn = {0022-3549 (Print) 0022-3549 (Linking)},
	doi = {10.1002/jps.2600841205},
	abstract = {The aim of the study was to investigate whether mannitol at amounts relevant to pharmaceutical formulations would alter the oral bioavailability of cimetidine, a drug primarily absorbed from the small bowel. Seven healthy male subjects each received four formulations, a chewable tablet or a solution, containing 0.200 g of cimetidine and either 2.264 g of mannitol or sucrose, in a randomized four-way cross-over study. Frequent blood samples were taken over a 24 h period to allow a cimetidine plasma profile to be obtained for each formulation. Transit of the radiolabeled formulations was followed by gamma scintigraphy. Statistically significant reductions in the AUC0-24 and maximum plasma concentration values were observed with the mannitol dosage forms compared to the sucrose controls. The mean small intestinal transit times were shortened after administration of the mannitol solution and tablet; the transit time of the solution was significantly shorter with values 23\% of those for the sucrose solution. The implication of the study findings is that excipients cannot always be regarded as "inert" substances that can be incorporated into a formulation without having any deleterious effect on the overall in vivo behaviour of the product.},
	number = {12},
	journal = {J Pharm Sci},
	author = {Adkin, D. A. and Davis, S. S. and Sparrow, R. A. and Huckle, P. D. and Wilding, I. R.},
	month = dec,
	year = {1995},
	keywords = {Administration, Oral, Adult, Anti-Ulcer Agents/*pharmacokinetics, Biological Availability, Cimetidine/*pharmacokinetics, Cross-Over Studies, Humans, Male, Mannitol/*pharmacology, Solutions, Sucrose/pharmacology, Tablets},
	pages = {1405--9},
}

@Article{Bavelier1994,
  author   = {D Bavelier},
  journal  = {Cognition},
  title    = {Repetition blindness between visually different items: {T}he case of pictures and words.},
  year     = {1994},
  number   = {3},
  pages    = {199-236},
  volume   = {51},
  abstract = {Repetition blindness (RB) is the failure to see or recall the second
	of two visually similar or identical items in rapid serial visual
	presentation. It was initially demonstrated by Kanwisher (1987),
	who proposed that a second token of a given word or object type cannot
	be established when the two items occur close in time. Bavelier and
	Potter (1992) showed that RB also occurs between visually different
	items that are phonologically similar. They proposed that RB may
	occur not only when the targets are physically similar, but also
	when they have to be registered or encoded in short-term memory (STM)
	along dimensions on which they are similar. This hypothesis predicts
	that RB between visually different items should not be restricted
	to words, but should occur with any stimuli, as long as the task
	requires these stimuli to be encoded along dimensions on which they
	are similar. Moreover, it also implies that a task that changes the
	preferred code of targets will affect the size of RB. The first prediction
	was confirmed by establishing RB between phonologically similar pictures
	and words, whether semantically related (the picture of a cat and
	the word "cat") or not (the picture of a sun and the word "son"),
	when using a task that requires phonological encoding (Experiments
	1 and 2). The second prediction was also supported: the magnitude
	of RB depended on whether the task required similar or different
	codes for pictures and words (Experiments 3 and 4). These experiments
	confirm that RB between visually different items is due to the similarity
	of the codes initially used in STM. The results suggest that RB can
	occur at any step during the instantiation of a token, arising not
	only from a failure to create a new token, but also from a failure
	to stabilize an opened token. In this view, tokens are to be seen
	as dynamical entities, built over time as a function of type activation
	and task requirements, and varying in stability as a function of
	the information that is entered into them.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, 8194301},
}

Paper  doi  abstract   bibtex   

@article{rao_relationship_1994,
	title = {The relationship between basal cell epithelioma and seborrheic keratosis. {A} study of 60 cases},
	volume = {20},
	copyright = {All rights reserved},
	issn = {0148-0812 (Print) 0148-0812 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/7962939},
	doi = {10.1111/j.1524-4725.1994.tb03201.x},
	abstract = {BACKGROUND: Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen. OBJECTIVE: To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis. METHODS: Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques. RESULTS: Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60). CONCLUSION: Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.},
	number = {11},
	journal = {J Dermatol Surg Oncol},
	author = {Rao, B. K. and Freeman, R. G. and Poulos, E. G. and Arbesfeld, L. and Rendon, M.},
	month = nov,
	year = {1994},
	keywords = {Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell/*complications/pathology, Cell Transformation, Neoplastic, Female, Humans, Keratosis, Seborrheic/*complications/pathology, Male, Middle Aged, Skin Neoplasms/*complications/pathology},
	pages = {761--4},
}

@article{
 title = {Frequency and intensity discrimination in humans and monkeys},
 type = {article},
 year = {1985},
 keywords = {Acoustic Stimulation,Adult,Animals,Auditory Perception/physiology,Cercopithecus aethiops/physiology,Female,Humans,Macaca/physiology,Male,Species Specificity,Speech Acoustics,Speech Perception/physiology,Vestibulocochlear Nerve/physiology},
 pages = {1977-1985},
 volume = {78},
 id = {163a1c5d-06e6-3686-9f07-6e1f76a6fc88},
 created = {2017-09-01T15:54:31.569Z},
 file_attached = {false},
 profile_id = {80da7853-f7b7-36a9-8e4c-d7ddb2d9e538},
 group_id = {a2333ea3-15a4-3d40-8d36-f0d9590ca926},
 last_modified = {2017-09-01T15:54:31.713Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 language = {eng},
 abstract = {Frequency and intensity DLs were compared in humans and monkeys using a repeating standard "yes-no" procedure in which subjects reported frequency increments, frequency decrements, intensity increments, or intensity decrements in an ongoing train of 1.0-kHz tone bursts. There was only one experimental condition (intensity increments) in which monkey DLs (1.5-2.0 dB) overlapped those of humans (1.0-1.8 dB). For discrimination of both increments and decrements in frequency, monkey DLs (16-33 Hz) were approximately seven times larger than those of humans (2.4-4.8 Hz), and for discrimination of intensity decrements, monkey DLs (4.4-7.0 dB) were very unstable and larger than those of humans (1.0-1.8 dB). For intensity increment discrimination, humans and monkeys also exhibited similar DLs as SL was varied. However, for frequency increment discrimination, best DLs for humans occurred at a high (50 dB) SL, whereas best DLs for monkeys occurred at a moderate (30 dB) SL. Results are discussed in terms of various neural mechanisms that might be differentially engaged by humans and monkeys in performing these tasks; for example, different amounts of temporal versus rate coding in frequency discrimination, and different mechanisms for monitoring rate decreases in intensity discrimination. The implications of these data for using monkeys as models of human speech sound discrimination are also discussed.},
 bibtype = {article},
 author = {Sinnott, J. and Petersen, M. and Hopp, S.},
 number = {6}
}

@Article{Phillips1985,
  author   = {DP Phillips and JR Mendelson and MS Cynader and RM Douglas},
  journal  = {Exp Brain Res},
  title    = {Responses of single neurones in cat auditory cortex to time-varying stimuli: {F}requency-modulated tones of narrow excursion.},
  year     = {1985},
  number   = {3},
  pages    = {443-54},
  volume   = {58},
  abstract = {In the primary auditory cortex of cats anaesthetized with nitrous
	oxide, single neurones were examined with respect to their responses
	to tone bursts and linear modulations of the frequency of an on-going
	continuous tone. Using FM ramps of 2.0 kHz excursion and varying
	centre frequency, each of 39 neurones was examined for its preference
	for the direction of frequency change of a ramp whose centre frequency
	was varied in and around the neurone's response area. Direction preference
	was strictly associated with the slopes of the cell's spike count-versus-frequency
	function over the frequency range covered by the ramp. Preferences
	for upward- and downward-directed ramps were associated with the
	low- and high-frequency slopes of the spike count function, respectively.
	The strength of the cell's direction preference was associated with
	the relative steepness of the spike count function over the frequency
	range covered by the ramp. The timing of discharges elicited by the
	frequency modulations was found to be the sum of the cell's latent
	period for tone bursts plus the time after ramp onset that the stimulus
	frequency fell within the neurone's response area. The implications
	of these data for the processing of narrow and broad frequency-modulated
	ramps are discussed.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, 4007088},
}

@Article{Potter1975,
  author   = {Mary C. Potter},
  journal  = {Science},
  title    = {Meaning in visual search.},
  year     = {1975},
  number   = {4180},
  pages    = {965-6},
  volume   = {187},
  abstract = {Viewers briefly glimpsed pictures presented in a sequence at rates
	up to eight per second. They recognized a target picture as accurately
	and almost as rapidly when they knew only its meaning given by a
	name (for example, a boat) as when they had seen the picture itself
	in advance.},
  keywords = {Adult, Form Perception, Humans, Memory, Pattern Recognition, Reaction Time, Visual, 1145183},
}