@article{oldfield_experiences_2022,
	title = {Experiences, patient interactions and knowledge regarding the use of cannabis as a medicine in a cohort of {New} {Zealand} doctors in an oncology setting},
	volume = {98},
	issn = {1469-0756},
	doi = {10.1136/postgradmedj-2020-139013},
	abstract = {PURPOSE OF STUDY: To explore the experiences, patient interactions and knowledge regarding the use of cannabis as a medicine in New Zealand doctors in an oncology setting.
STUDY DESIGN: An observational cross-sectional survey undertaken between November 2019 and January 2020 across four secondary-care hospital oncology departments within New Zealand (Auckland, Wellington, Christchurch and Dunedin). Participants were a convenience sample of doctors; consultants, registrars, medical officers of special status and house surgeons working in oncology departments. Of 53 individuals approached, 45 participated (85\% Response Rate). The primary outcome was reporteddoctor-patient interactions. Secondary outcomes included knowledge of cannabis-based products, their efficacy, prescribing regulations and educational access.
RESULTS: Of 44 doctors, 37 (84\%, 95\% CI: 70 to 93) reported patient requests to prescribe cannabis-based products and 43 (98\%, 95\% CI: 88 to 100) reported patients using illicit cannabis for medical symptoms. Primary request reasons were pain, nausea/vomiting and cancer treatment. 33/45 (73\%, 95\% CI: 58 to 85) cited knowledge of at least one cannabis-based product and 27/45 (60\%, 95\% CI: 44 to 74) indicated at least one condition that had evidence of efficacy. 36/44 (82\%, 95\% CI: 67 to 92) expressed future prescribing concerns but all were willing to use a cannabis-based product developed with traditional medical provenance.
CONCLUSION: In the oncology setting, patients are asking doctors about symptomatic and curative treatment with cannabis-based products. Doctors are not biased against the use of products showing medical provenance; however, NZ-specific clinical and regulatory guidelines are essential to support patient discussions and appropriate prescribing.},
	language = {eng},
	number = {1155},
	journal = {Postgraduate Medical Journal},
	author = {Oldfield, Karen and Eathorne, Allie and Tewhaiti-Smith, Jordan and Beasley, Richard and Semprini, Alex and Braithwaite, Irene},
	month = jan,
	year = {2022},
	pmid = {33218966},
	keywords = {Adult, Aged, Attitude of Health Personnel, Cannabis, Cross-Sectional Studies, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Medical Marijuana, Medicine, Middle Aged, Neoplasms, New Zealand, Oncology, Physician-Patient Relations, Physicians, chemotherapy, complementary medicine, education \& training (see medical education \& training), pain management},
	pages = {35--42},
}

@article{li_risk_2021,
	title = {Risk factors for poor outcomes in hospitalised {COVID}-19 patients: {A} systematic review and meta-analysis},
	volume = {11},
	issn = {2047-2986},
	shorttitle = {Risk factors for poor outcomes in hospitalised {COVID}-19 patients},
	doi = {10.7189/jogh.11.10001},
	abstract = {Background: Understanding the risk factors for poor outcomes among COVID-19 patients could help identify vulnerable populations who would need prioritisation in prevention and treatment for COVID-19. We aimed to critically appraise and synthesise published evidence on the risk factors for poor outcomes in hospitalised COVID-19 patients.
Methods: We searched PubMed, medRxiv and the WHO COVID-19 literature database for studies that reported characteristics of COVID-19 patients who required hospitalisation. We included studies published between January and May 2020 that reported adjusted effect size of any demographic and/or clinical factors for any of the three poor outcomes: mortality, intensive care unit (ICU) admission, and invasive mechanical ventilation. We appraised the quality of the included studies using Joanna Briggs Institute appraisal tools and quantitatively synthesised the evidence through a series of random-effect meta-analyses. To aid data interpretation, we further developed an interpretation framework that indicated strength of the evidence, informed by both quantity and quality of the evidence.
Results: We included a total of 40 studies in our review. Most of the included studies (29/40, 73\%) were assessed as "good quality", with assessment scores of 80 or more. We found that male sex (pooled odds ratio (OR) = 1.32 (95\% confidence interval (CI) = 1.18-1.48; 20 studies), older age (OR = 1.05, 95\% CI = 1.04-1.07, per one year of age increase; 10 studies), obesity (OR = 1.59, 95\% CI = 1.02-2.48; 4 studies), diabetes (OR = 1.25, 95\% CI = 1.11-1.40; 11 studies) and chronic kidney diseases (6 studies; OR = 1.57, 95\% CI = 1.27-1.93) were associated with increased risks for mortality with the greatest strength of evidence based on our interpretation framework. We did not find increased risk of mortality for several factors including chronic obstructive pulmonary diseases (5 studies), cancer (4 studies), or current smoker (5 studies); however, this does not indicate absence of risk due to limited data on each of these factors.
Conclusion: Male sex, older age, obesity, diabetes and chronic kidney diseases are important risk factors of COVID-19 poor outcomes. Our review provides not only an appraisal and synthesis of evidence on the risk factors of COVID-19 poor outcomes, but also a data interpretation framework that could be adopted by relevant future research.},
	language = {eng},
	journal = {Journal of Global Health},
	author = {Li, You and Ashcroft, Thulani and Chung, Alexandria and Dighero, Izzie and Dozier, Marshall and Horne, Margaret and McSwiggan, Emilie and Shamsuddin, Azwa and Nair, Harish},
	month = mar,
	year = {2021},
	pmid = {33767855},
	pmcid = {PMC7980087},
	keywords = {Aged, COVID-19, Comorbidity, Female, Hospitalization, Humans, Intensive Care Units, Male, Respiration, Artificial, Risk Factors, SARS-CoV-2, Severity of Illness Index},
	pages = {10001},
}

Paper  doi  bibtex   

@article{degenhardt_perceived_2021,
	title = {Perceived helpfulness of treatment for alcohol use disorders: {Findings} from the {World} {Mental} {Health} {Surveys}},
	volume = {229},
	issn = {03768716},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120963570&doi=10.1016%2fj.drugalcdep.2021.109158&partnerID=40&md5=134711ac79b2bfbba08a90b62df24d71},
	doi = {10.1016/j.drugalcdep.2021.109158},
	language = {English},
	journal = {Drug and Alcohol Dependence},
	author = {Degenhardt, L. and Bharat, C. and Chiu, W.T. and Sampson, N.A. and Kessler, R.C. and Kazdin, A.E. and Harris, M.G. and Harris, M.G. and McGrath, J.J. and Vigo, D.V. and Vigo, D.V. and Alonso, J. and Alonso, J. and Alonso, J. and Andrade, L.H. and Bruffaerts, R. and Bunting, B. and Cardoso, G. and de Girolamo, G. and Florescu, S. and Gureje, O. and Makanjuola, V. and Haro, J.M. and Hu, C. and Karam, A.N. and Karam, E.G. and Karam, E.G. and Karam, E.G. and Kovess-Masfety, V. and Lee, S. and McGrath, J.J. and McGrath, J.J. and Medina-Mora, M.E. and Moskalewicz, J. and Navarro-Mateu, F. and Navarro-Mateu, F. and Navarro-Mateu, F. and Posada-Villa, J. and Rapsey, C. and Stagnaro, J.C. and Tachimori, H. and ten Have, M. and Torres, Y. and Williams, D.R. and Zarkov, Z. and Al-Hamzawi, A. and Al-Kaisy, M.S. and Alonso, J. and Altwaijri, Y.A. and Andrade, L.H. and Atwoli, L. and Benjet, C. and Borges, G. and Bromet, E.J. and Bruffaerts, R. and Bunting, B. and Caldas-de-Almeida, J.M. and Cardoso, G. and Chatterji, S. and Cia, A.H. and Degenhardt, L. and Demyttenaere, K. and Florescu, S. and Girolamo, Giovanni de and Gureje, O. and Haro, J.M. and Harris, M.G. and Hinkov, H. and Hu, C.-Y. and Jonge, Peter de and Karam, A.N. and Karam, E.G. and Karam, G. and Kawakami, N. and Kessler, R.C. and Kiejna, A. and Kovess-Masfety, V. and Lee, S. and Lepine, J.-P. and McGrath, J.J. and Medina-Mora, M.E. and Mneimneh, Z. and Moskalewicz, J. and Navarro-Mateu, F. and Piazza, M. and Posada-Villa, J. and Scott, K.M. and Slade, T. and Stagnaro, J.C. and Stein, D.J. and Have, Margreet ten and Torres, Y. and Viana, M.C. and Vigo, D.V. and Whiteford, H. and Williams, D.R. and Wojtyniak, B.},
	year = {2021},
	note = {Publisher: Elsevier Ireland Ltd},
	keywords = {Article, adult, aged, alcoholism, alternative medicine, controlled study, cooperation, drug abuse, female, help seeking behavior, high income country, human, low income country, male, middle income country, prevalence, probability, psychotherapy, treatment failure},
}

Paper  doi  bibtex   

@article{jansen_burden_2020,
	title = {Burden of {Illness} and {Quality} of {Life} in {Tuberous} {Sclerosis} {Complex}: {Findings} {From} the {TOSCA} {Study}},
	volume = {11},
	issn = {16642295},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090896990&doi=10.3389%2ffneur.2020.00904&partnerID=40&md5=1faa143e97a93bf95e1228ed0c704c24},
	doi = {10.3389/fneur.2020.00904},
	language = {English},
	journal = {Frontiers in Neurology},
	author = {Jansen, A.C. and Vanclooster, S. and de Vries, P.J. and Fladrowski, C. and Beaure d'Augères, G. and Carter, T. and Belousova, E. and Benedik, M.P. and Cottin, V. and Curatolo, P. and Dahlin, M. and D'Amato, L. and Ferreira, J.C. and Feucht, M. and Hertzberg, C. and Jozwiak, S. and Lawson, J.A. and Macaya, A. and Marques, R. and Nabbout, R. and O'Callaghan, F. and Qin, J. and Sander, V. and Sauter, M. and Shah, S. and Takahashi, Y. and Touraine, R. and Youroukos, S. and Zonnenberg, B. and Kingswood, J.C. and Shinohara, N. and Horie, S. and Kubota, M. and Tohyama, J. and Imai, K. and Kaneda, M. and Kaneko, H. and Uchida, Y. and Kirino, T. and Endo, S. and Inoue, Y. and Uruno, K. and Serdaroglu, A. and Yapici, Z. and Anlar, B. and Altunbasak, S. and Lvova, O. and Belyaev, O.V.B. and Agranovich, O. and Levitina, E.V.L. and Maksimova, Y.V.M. and Karas, A. and Jiang, Y. and Zou, L. and Xu, K. and Zhang, Y. and Luan, G. and Zhang, Y. and Wang, Y. and Jin, M. and Ye, D. and Ye, D. and Zhou, L. and Liu, J. and Liao, J. and YAN, B. and Deng, Y. and Jiang, L. and Liu, Z. and Huang, S. and Li, H. and Kim, K. and Chen, P.-L. and Lee, H.-F. and Tsai, J.-D. and Chi, C.-S. and Huang, C.-C. and Riney, K. and Yates, D. and Kwan, P. and Likasitwattanakul, S. and Nabangchang, C. and Chomtho, L.T.K. and Katanyuwong, K. and Sriudomkajorn, S. and Wilmshurst, J. and Segel, R. and Gilboa, T. and Tzadok, M. and Fattal-Valevski, T. and Papathanasopoulos, P. and Papavasiliou, A.S.P. and Giannakodimos, S. and Gatzonis, S. and Pavlou, E. and Tzoufi, M. and Vergeer, A.M.H. and Dhooghe, M. and Verhelst, H. and Roelens, F. and Nassogne, M.C.N. and Defresne, P. and Waele, L.D.W. and Leroy, P. and Demonceau, N. and Legros, B. and Bogaert, P.V.B. and Ceulemans, B. and Dom, L. and Castelnau, P. and Martin, A.D.S. and Riquet, A. and Milh, M. and Cances, C. and Pedespan, J.-M. and Ville, D. and Roubertie, A. and Auvin, S. and Berquin, P. and Richelme, C. and Allaire, C. and Gueden, S. and Tich, S.N.T. and Godet, B. and da Silva Oliveira Monteiro, J.P. and de Oliveira Ferreira Leao, M.J.S. and Planas, J.C.P. and Bermejo, A.M.B. and Dura, P.S.D. and Aparicio, S.R.A. and Gonzalez, M.J.M. and Pison, J.L.P. and Barca, M.O.B. and Laso, E.L.L. and Luengo, O.A.L. and Rodriguez, F.J.A. and Dieguez, I.M.D. and Salas, A.C.S. and Carrera, I.M.C. and Salcedo, E.M.S. and Petri, M.E.Y. and Candela, R.C.C. and da Conceicao Carrilho, I. and Vieira, J.P.V. and da Silva Oliveira Monteiro, J.P. and de Oliveira Ferreira Leao, M.J.S. and Luis, C.S.M.R. and Mendonca, C.P.M. and Endziniene, M. and Strautmanis, J. and Talvik, I. and Canevini, M.P.C. and Gambardella, A. and Pruna, D. and Buono, S. and Fontana, E. and Bernardina, B.D.B. and Burloiu, C. and Cosma, I.S.B. and Vintan, M.A.V. and Popescu, L. and Zitterbart, K. and Payerova, J. and Bratsky, L. and Zilinska, Z. and Sedlmayr, U.G. and Baumann, M. and Haberlandt, E. and Rostasy, K. and Pataraia, E. and Elmslie, F. and Johnston, C.A.J. and Crawford, P. and Uldall, P. and Uvebrant, P. and Rask, O. and Bjoernvold, M. and Brodtkorb, E. and Sloerdahl, A. and Solhoff, R. and Jaatun, M.S.G. and Mandera, M. and Radzikowska, E.J.R. and Wysocki, M. and Fischereder, M. and Kurlemann, G. and Wilken, B. and K-ruel, A.W.K. and Budde, K. and Marquard, K. and Knuf, M. and Hahn, A. and Hartmann, H. and Merkenschlager, A. and Trollmann, R. and Investigators, TOSCA Consortium TOSCA},
	year = {2020},
	note = {Publisher: Frontiers Media S.A.},
	keywords = {Article, adolescent, adult, aged, career, caregiver, child, disease burden, educational status, employment, family life, female, human, informed consent, major clinical study, male, patient care, personal experience, psychological well-being, quality of life, questionnaire, social psychology, social support, tuberous sclerosis, unemployment, validation process},
}

Paper  doi  abstract   bibtex   

@article{widerstrom_aspects_2019,
	title = {Aspects influencing clinical reasoning and decision-making when matching treatment to patients with low back pain in primary healthcare},
	volume = {41},
	issn = {2468-7812},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30818071},
	doi = {10.1016/j.msksp.2019.02.003},
	abstract = {BACKGROUND: It is unclear how physiotherapists match treatment to patients with low-back pain (LBP) in primary healthcare. A further exploration of physiotherapists' perspective of matching treatments to the individual patient in this setting is needed. OBJECTIVE: The aim of this study was to explore and describe aspects influencing physiotherapists' clinical reasoning in the decision-making on individualized treatment of LBP in primary healthcare. DESIGN: This was an explorative study using qualitative content analysis. METHOD: Fifteen semi-structured individual interviews were conducted with physiotherapists, men and women, experienced and novice, working in primary healthcare settings in one sparsely populated region and in one larger city in Sweden. FINDINGS: Two overarching themes were identified influencing decision-making for individualized treatment of LBP: 1) Matching requires differentiation and adaptation, with categories describing specific patient characteristics, assessment findings and treatment adaptations (classification of pain and bodily findings; patient physical capacity and emotions; patient awareness and motivation; treatment combinations and atypical treatment rationales): and 2) The tension between trust and barriers; with categories describing aspects of physiotherapists' convictions, constraints and working environment (confidence in treatments and oneself; physiotherapists' terms overrule patients' preferences; personal constraints and workplace approach and priorities). CONCLUSION: This study describes aspects of the patients, the physiotherapists and their workplaces that influence decisions for individualized treatment of LBP. The findings underpin the need for clinician self-reflection, initiatives for skilled clinical competence and the weight clinician observations carry on the complex treatment selection process which need to be appreciated when implementing evidence-based recommendations in clinical practice.},
	language = {eng},
	journal = {Musculoskeletal science \& practice},
	author = {Widerström, Birgitta and Rasmussen-Barr, Eva and Boström, Carina},
	month = jun,
	year = {2019},
	keywords = {*Attitude of Health Personnel, *Health Knowledge, Attitudes, Practice, *Professional-Patient Relations, Adult, Aged, Aged, 80 and over, Decision Making, Female, Humans, Low Back Pain/*therapy, Male, Middle Aged, Patient Preference/*psychology, Physical Therapists/*psychology, Primary Health Care/*methods, Qualitative Research},
	pages = {6--14},
}

Paper  doi  abstract   bibtex   

@article{barbour_d_l_online_2019,
	title = {Online {Machine} {Learning} {Audiometry}},
	volume = {40},
	issn = {1538-4667},
	url = {https://journals.lww.com/ear-hearing/Abstract/2019/07000/Online_Machine_Learning_Audiometry.14.aspx},
	doi = {10.1097/AUD.0000000000000669},
	abstract = {OBJECTIVES: A confluence of recent developments in cloud computing, real-time web audio and machine learning psychometric function estimation has made wide dissemination of sophisticated turn-key audiometric assessments possible. The authors have combined these capabilities into an online (i.e., web-based) pure-tone audiogram estimator intended to empower researchers and clinicians with advanced hearing tests without the need for custom programming or special hardware. The objective of this study was to assess the accuracy and reliability of this new online machine learning audiogram method relative to a commonly used hearing threshold estimation technique also implemented online for the first time in the same platform.
DESIGN: The authors performed air conduction pure-tone audiometry on 21 participants between the ages of 19 and 79 years (mean 41, SD 21) exhibiting a wide range of hearing abilities. For each ear, two repetitions of online machine learning audiogram estimation and two repetitions of online modified Hughson-Westlake ascending-descending audiogram estimation were acquired by an audiologist using the online software tools. The estimated hearing thresholds of these two techniques were compared at standard audiogram frequencies (i.e., 0.25, 0.5, 1, 2, 4, 8 kHz).
RESULTS: The two threshold estimation methods delivered very similar threshold estimates at standard audiogram frequencies. Specifically, the mean absolute difference between threshold estimates was 3.24 ± 5.15 dB. The mean absolute differences between repeated measurements of the online machine learning procedure and between repeated measurements of the Hughson-Westlake procedure were 2.85 ± 6.57 dB and 1.88 ± 3.56 dB, respectively. The machine learning method generated estimates of both threshold and spread (i.e., the inverse of psychometric slope) continuously across the entire frequency range tested from fewer samples on average than the modified Hughson-Westlake procedure required to estimate six discrete thresholds.
CONCLUSIONS: Online machine learning audiogram estimation in its current form provides all the information of conventional threshold audiometry with similar accuracy and reliability in less time. More importantly, however, this method provides additional audiogram details not provided by other methods. This standardized platform can be readily extended to bone conduction, masking, spectrotemporal modulation, speech perception, etc., unifying audiometric testing into a single comprehensive procedure efficient enough to become part of the standard audiologic workup.},
	language = {eng},
	number = {4},
	journal = {Ear and Hearing},
	author = {{Barbour, D. L.} and Howard, Rebecca T. and Song, Xinyu D. and Metzger, Nikki and Sukesan, Kiron A. and DiLorenzo, James C. and Snyder, Braham R. D. and Chen, Jeff Y. and Degen, Eleanor A. and Buchbinder, Jenna M. and Heisey, Katherine L.},
	month = aug,
	year = {2019},
	pmid = {30358656},
	pmcid = {PMC6476703},
	keywords = {Adult, Aged, Audiometry, Pure-Tone, Female, Hearing Loss, Humans, Internet, Machine Learning, Male, Middle Aged, Reproducibility of Results, Severity of Illness Index, Young Adult},
	pages = {918--926},
}

@article {650292,
	title = {Ovarian Cancer: Prevalence in Incidental Simple Adnexal Cysts Initially Identified in CT Examinations of the Abdomen and Pelvis},
	journal = {Radiology},
	volume = {286},
	number = {1},
	year = {2018},
	month = {2018 01},
	pages = {196-204},
	abstract = {Purpose To evaluate the rate of malignancy in incidentally detected simple adnexal cysts at computed tomography (CT) to determine if simple-appearing cysts require follow-up. Materials and Methods In this HIPAA-compliant, institutional review board-approved retrospective cohort study, an institutional database was searched for abdominal and pelvic CT studies performed between June 2003 and December 2010 in women reported to have adnexal cysts. Adnexal cyst characterization was determined by prospective report description as well as image review by a research fellow and by a fellowship-trained abdominal radiologist for examinations with disagreement between the original report and the research fellow{\textquoteright}s assessment. Patients with known ovarian cysts or ovarian cancer at time of the index CT examination were excluded. Clinical outcome was assessed by using follow-up imaging studies, medical records, and the state cancer registry. Benign outcome was determined by benign findings at surgery, a decrease in size or resolution of a simple-appearing cyst at follow-up imaging, or stability of the cyst for at least 1 year. Descriptive statistics and 95\% confidence intervals (CIs) were calculated. Results Among 42 111 women who underwent abdominal and pelvic CT examinations in the study period, 2763 (6.6\%; 95\% CI: 6.3\%, 6.8\%) (mean age, 48.1 years {\textpm} 18.1; range, 15-102 years) had a newly detected finding of ovarian cyst described in the body or impression section of the report. Median cyst size was 3.1 cm (range, 0.8-20.0 cm). Eighteen (0.7\%; 95\% CI: 0.4\%, 1.0\%) of 2763 patients were found to have ovarian cancer after an average follow-up of 5.1 years {\textpm} 3.8 (range, 0-12.8 years). None (95\% CI: 0\%, 0.4\%) of 1031 women with simple-appearing cysts were given a diagnosis of ovarian cancer. This included none (95\% CI: 0\%, 0.4\%) of 904 women with simple-appearing cysts with an adequate reference standard for benign outcome. Conclusion The prevalence of previously unknown adnexal cysts at CT was 6.6\%, with an ovarian cancer rate of 0.7\% (95\% CI: 0.4\%, 1.0\%). All simple-appearing cysts were benign (95\% CI: 99.6\%, 100\%).  RSNA, 2017 Online supplemental material is available for this article.},
	keywords = {Abdomen, Adult, Aged, Female, Humans, Incidental Findings, Middle Aged, Ovarian Cysts, Ovarian Neoplasms, Pelvis, Retrospective Studies, Tomography, X-Ray Computed},
	issn = {1527-1315},
	doi = {10.1148/radiol.2017162139},
	author = {Johannes Boos and Olga R Brook and Jieming Fang and Alexander Brook and Levine, Deborah}
}

@article{bousiges_cerebrospinal_2018-1,
	title = {Cerebrospinal fluid {Alzheimer} biomarkers can be useful for discriminating dementia with {Lewy} bodies from {Alzheimer}'s disease at the prodromal stage},
	volume = {89},
	issn = {1468-330X},
	doi = {10.1136/jnnp-2017-316385},
	abstract = {BACKGROUND: Differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) is not straightforward, especially in the early stages of disease. We compared AD biomarkers (phospho-Tau181, total-Tau, Aβ42 and Aβ40) in cerebrospinal fluid (CSF) of patients with DLB and AD, focusing especially on the prodromal stage.
METHODS: A total of 1221 CSF were collected in different memory centres (ePLM network) in France and analysed retrospectively. Samples were obtained from patients with prodromal DLB (pro-DLB; n=57), DLB dementia (DLB-d; n=154), prodromal AD (pro-AD; n=132) and AD dementia (n=783), and control subjects (CS; n=95). These centres use the same diagnostic procedure and criteria to evaluate the patients.
RESULTS: In patients with pro-DLB, CSF Aβ42 levels appeared much less disrupted than in patients at the demented stage (DLB-d) (P{\textless}0.05 CS{\textgreater}pro-DLB; P{\textless}0.001 CS{\textgreater}DLB-d). On average, Aβ40 levels in patients with DLB (pro-DLB and DLB-d) were much below those in patients with pro-AD (P{\textless}0.001 DLB groups{\textless}pro-AD). The Aβ42/Aβ40 ratio in patients with pro-DLB remained close to that of CS. t-Tau and phospho-Tau181 levels were unaltered in patients with DLB (pro-DLB and DLB-d).
CONCLUSIONS: Reduced levels of CSF Aβ42 were found in patients with DLB but rather at a later stage, reaching those of patients with AD, in whom Aβ42 levels were decreased even at the prodromal stage. At the prodromal stage of DLB, the majority of patients presented a normal CSF profile. CSF t-Tau and phospho-Tau181 were the best biomarkers to discriminate between AD and DLB, whatever the stage of disease.},
	language = {eng},
	number = {5},
	journal = {Journal of Neurology, Neurosurgery, and Psychiatry},
	author = {Bousiges, Olivier and Bombois, Stephanie and Schraen, Susanna and Wallon, David and Quillard, Muriel Muraine and Gabelle, Audrey and Lehmann, Sylvain and Paquet, Claire and Amar-Bouaziz, Elodie and Magnin, Eloi and Miguet-Alfonsi, Carole and Delbeuck, Xavier and Lavaux, Thomas and Anthony, Pierre and Philippi, Nathalie and Blanc, Frederic and {ePLM network and collaborators}},
	month = may,
	year = {2018},
	pmid = {29321140},
	keywords = {Aged, Alzheimer Disease, Amyloid beta-Peptides, Biomarkers, Case-Control Studies, Diagnosis, Differential, Female, Humans, Lewy Body Disease, Male, Middle Aged, Peptide Fragments, Prodromal Symptoms, Retrospective Studies, tau Proteins},
	pages = {467--475},
}

@article{alcalay_alpha_2018,
	title = {Alpha galactosidase {A} activity in {Parkinson}'s disease},
	volume = {112},
	issn = {1095-953X},
	doi = {10.1016/j.nbd.2018.01.012},
	abstract = {Glucocerebrosidase (GCase, deficient in Gaucher disease) enzymatic activity measured in dried blood spots of Parkinson's Disease (PD) cases is within healthy range but reduced compared to controls. It is not known whether activities of additional lysosomal enzymes are reduced in dried blood spots in PD. To test whether reduction in lysosomal enzymatic activity in PD is specific to GCase, we measured GCase, acid sphingomyelinase (deficient in Niemann-Pick disease types A and B), alpha galactosidase A (deficient in Fabry), acid alpha-glucosidase (deficient in Pompe) and galactosylceramidase (deficient in Krabbe) enzymatic activities in dried blood spots of PD patients (n = 648) and controls (n = 317) recruited from Columbia University. Full sequencing of glucocerebrosidase (GBA) and the LRRK2 G2019S mutation was performed. Enzymatic activities were compared between PD cases and controls using t-test and regression models adjusted for age, gender, and GBA and LRRK2 G2019S mutation status. Alpha galactosidase A activity was lower in PD cases compared to controls both when only non-carriers were included (excluding all GBA and LRRK2 G2019S carriers and PD cases with age-at-onset below 40) [2.85 μmol/l/h versus 3.12 μmol/l/h, p = 0.018; after controlling for batch effect, p = 0.006 (468 PD cases and 296 controls)], and when including the entire cohort (2.89 μmol/l/h versus 3.10 μmol/l/h, p = 0.040; after controlling for batch effect, p = 0.011). Because the alpha galactosidase A gene is X-linked, we stratified the analyses by sex. Among women who were non-carriers of GBA and LRRK2 G2019S mutations (PD, n = 155; control, n = 194), alpha galactosidase A activity was lower in PD compared to controls (2.77 μmol/l/h versus 3.10 μmol/l/h, p = 0.044; after controlling for a batch effect, p = 0.001). The enzymatic activity of acid sphingomyelinase, acid alpha-glucosidase and galactosylceramidase was not significantly different between PD and controls. In non-carriers, most lysosomal enzyme activities were correlated, with the strongest association in GCase, acid alpha-glucosidase, and alpha galactosidase A (Pearson correlation coefficient between 0.382 and 0.532). In a regression model with all five enzymes among non-carriers (adjusted for sex and age), higher alpha galactosidase A activity was associated with lower odds of PD status (OR = 0.54; 95\% CI:0.31-0.95; p = 0.032). When LRRK2 G2019S PD carriers (n = 37) were compared to non-carriers with PD, carriers had higher GCase, acid sphingomyelinase and alpha galactosidase A activity. We conclude that alpha galactosidase A may have a potential independent role in PD, in addition to GCase.},
	language = {eng},
	journal = {Neurobiology of Disease},
	author = {Alcalay, R. N. and Wolf, P. and Levy, O. A. and Kang, U. J. and Waters, C. and Fahn, S. and Ford, B. and Kuo, S. H. and Vanegas, N. and Shah, H. and Liong, C. and Narayan, S. and Pauciulo, M. W. and Nichols, W. C. and Gan-Or, Z. and Rouleau, G. A. and Chung, W. K. and Oliva, P. and Keutzer, J. and Marder, K. and Zhang, X. K.},
	month = apr,
	year = {2018},
	pmid = {29369793},
	pmcid = {PMC5811339},
	keywords = {Aged, Biomarkers, Cohort Studies, Enzyme Activation, Female, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Lysosomal storage disease, Male, Middle Aged, Movement disorders, Neurodegeneration, Parkinson Disease, Parkinson's disease, alpha-Galactosidase},
	pages = {85--90},
}

@article{koyama_serum_2017,
	title = {Serum ferritin level is a prognostic marker in patients with peripheral {T}-cell lymphoma},
	volume = {39},
	issn = {1751-553X},
	doi = {10.1111/ijlh.12592},
	abstract = {INTRODUCTION

The prognostic value of serum ferritin level in patients with peripheral T-cell lymphoma (PTCL) remains unknown.


METHODS

We retrospectively analyzed clinical data from 78 consecutive patients with newly diagnosed PTCL that were treated with anthracycline-containing regimens between 1998 and 2011.


RESULTS

The patients consisted of 50 males and 28 females with a median age of 64 years (range, 16-83 years). The subtypes of PTCL were 39 PTCL, not otherwise specified and 39 angioimmunoblastic T-cell lymphoma (AITL). The median observation period for the surviving patients was 50 months. The overall survival (OS) was poorer in patients with serum ferritin level above the upper normal limit (n = 28), compared with patients with serum ferritin level within normal range (n = 50; 4-year OS: 23\% vs. 72\%; P {\textless} 0.001). In the multivariate analysis, poor performance status (P = 0.006) and elevated serum ferritin level (P = 0.018) were independent risk factors for poor OS.


CONCLUSION

Serum ferritin level is a useful prognostic marker for PTCL.},
	number = {1},
	journal = {International journal of laboratory hematology},
	author = {Koyama, S and Fujisawa, S and Watanabe, R and Itabashi, M and Ishibashi, D and Ishii, Y and Hattori, Y and Nakajima, Y and Motohashi, K and Takasaki, H and Kawasaki, R and Hashimoto, C and Yamazaki, E and Koharazawa, H and Takemura, S and Tomita, N and Sakai, R and Motomura, S and Nakajima, H},
	month = feb,
	year = {2017},
	pmid = {27885817},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Anthracyclines, Disease-Free Survival, Female, Ferritins, Humans, Lymphoma, T-Cell, Peripheral, Male, Middle Aged, Retrospective Studies, Survival Rate},
	pages = {112--117}
}

Paper  abstract   bibtex   

@article{correa-selm_use_2017,
	title = {Use of {Biologics} in {Private} {Practice}: {Nine} {Years} of {Lessons} and {Learning}},
	volume = {16},
	copyright = {All rights reserved},
	issn = {1545-9616 (Print) 1545-9616 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/28301616},
	abstract = {{\textless}p{\textgreater}Over a decade ago, the FDA approved biologics for psoriasis, which changed how the disease is treated and, in most cases, has a significant positive impact on the lives of patients. Side effects primarily identified during the investigational and research phase led to the development of specific guidelines for treatment. The treatment guidelines have been amended to incorporate better understandings of side-effects over the years that the disease has been treated. In this study, we focused on a chart review that included assessing the current guidelines and their alignment with modern patient management and the recent side effects presented. This life-cycle evaluation included over 100 patients, management of their treatment, laboratory abnormalities, criteria for choosing or changing to a different biologic, and the effects of the treatments management throughout the years. The review identified some recommended changes in the application and treatment of psoriasis with biologics. To further evidence our findings, we hope to expand this study to a larger scale with more patients.{\textless}/p{\textgreater} {\textless}p{\textgreater}{\textless}em{\textgreater}J Drugs Dermatol. 2017;16(3):215-217.{\textless}/em{\textgreater}{\textless}/p{\textgreater}.},
	number = {3},
	journal = {J Drugs Dermatol},
	author = {Correa-Selm, L. M. and Alamgir, M. and Rao, B. K.},
	month = mar,
	year = {2017},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Biological Products/administration \& dosage/adverse effects/*therapeutic use, Child, Female, Humans, Male, Middle Aged, Practice Guidelines as Topic, Private Practice/*trends, Psoriasis/blood/*drug therapy, Quality of Life, Retrospective Studies, Severity of Illness Index, Young Adult},
	pages = {215--217},
}

@article{de_reuck_frequency_2017,
	title = {Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia: a post-mortem 7-tesla magnetic resonance imaging study with neuropathological correlates},
	volume = {55},
	issn = {1509-572X},
	shorttitle = {Frequency and topography of small cerebrovascular lesions in vascular and in mixed dementia},
	doi = {10.5114/fn.2017.66711},
	abstract = {\textit{\textbf{Introduction}: Mixed dementia (MixD) refers to a combination of definite Alzheimer's disease (AD) and vascular encephalopathy. The existence of a "pure" type of vascular dementia (VaD) is controversial. There is a need to find magnetic resonance imaging (MRI) characteristics allowing the distinction between VaD and MixD. The present post-mortem 7.0-tesla MRI compares the frequency or severity and the topography of the small cerebrovascular lesions in brains of patients with VaD and with MixD. \textbf{Material and methods}: Based on neuropathological criteria, 14 brains were classified as VaD, 24 as MixD and 11 as controls. Three coronal sections of a cerebral hemisphere and a horizontal section of a cerebellar hemisphere underwent T2 and T2* 7.0-tesla MRI examination. The mean values and topographic distribution of white matter changes (WMCs), lacunar infarcts (LIs), cortical microbleeds (CoMBs) and cortical microinfarcts (CoMIs) were determined and compared between the different groups. \textbf{Results}: Compared to the controls, both VaD and MixD brains had significantly more severe WMCs and increased numbers of CoMBs and CoMIs. Lacunar infarcts predominated only in the VaD cases. On mutual comparison of VaD and MixD brains, CoMBs and CoMIs predominated in the frontal lobe and the cerebellum of VaD, while were mainly present in the occipital lobe of MixD. White matter changes predominated in the temporal lobe of MixD cases. Lacunar infarcts were significantly increased in the corona radiata and putamen of VaD patients. \textbf{Conclusions}: The present post-mortem MRI study shows clear differences in the distribution and the types of cerebrovascular lesions on high-field MRI, confirming that VaD and MixD are different diseases. }.},
	language = {eng},
	number = {1},
	journal = {Folia Neuropathologica},
	author = {De Reuck, Jacques and Auger, Florent and Durieux, Nicolas and Deramecourt, Vincent and Maurage, Claude-Alain and Cordonnier, Charlotte and Pasquier, Florence and Leys, Didier and Bordet, Regis},
	year = {2017},
	pmid = {28430290},
	keywords = {Aged, Humans, Magnetic Resonance Imaging, Dementia, Female, Male, Brain, Autopsy, vascular dementia, cortical microbleeds, cortical microinfarcts, lacunar infarcts, mixed dementia, post-mortem 7.0-tesla MRI, topographic distribution of small cerebrovascular lesions, white matter changes},
	pages = {31--37}
}

@article{pascual_bloodstream_2016,
	title = {Bloodstream infections caused by {Escherichia} coli producing {AmpC} β-lactamases: epidemiology and clinical features},
	volume = {35},
	issn = {1435-4373},
	shorttitle = {Bloodstream infections caused by {Escherichia} coli producing {AmpC} β-lactamases},
	doi = {10.1007/s10096-016-2752-3},
	abstract = {The aim of the study was to investigate the epidemiology and clinical features of bloodstream infections due to Escherichia coli producing AmpC β-lactamases (AmpC-Ec-BSI). In a multi-centre case-control study, all third-generation-cephalosporin-resistant Escherichia coli BSI (3GC-Ec-BSI) isolates were analysed. Acquired bla AmpC (bla ac-AmpC) detection was done by polymerase chain reaction (PCR) and sequencing. Chromosomal bla AmpC (bla c-AmpC) expression was quantified by real-time PCR. Cases were patients with AmpC-Ec-BSI. Controls were patients with cephalosporin-susceptible E. coli BSI, matched 1:1 by sex and age. Demographics, comorbidities, intrinsic and extrinsic risk factors for antimicrobial resistance, clinical presentation and outcomes were investigated. Among 841 E. coli BSI, 17 were caused by AmpC-Ec (2 \%). Eleven isolates (58.8 \%) had bla ac-AmpC and six were bla c-AmpC overproducers. The mean age of cases was 66.2 years and 71 \% were men. Cases were more frequently healthcare-related (82 vs. 52 \% controls, p {\textless} 0.05) and presented more intrinsic and extrinsic risk factors. At least one risk factor was present in 94.1 \% of cases vs. 41.7 \% of controls (p = 0.002). Severity and length of stay (LOS) were higher among cases (mean Pitt Score 2.6 vs. 0.38 in controls, p = 0.03; LOS 17.5 days vs. 6 in controls, p = 0.02). Inappropriate empirical therapy (IET) was administered to 70.6 \% of cases and 23.5 \% of controls (p {\textless} 0.003). No differences were found in terms of cure rate at the 14th day and mortality. Bloodstream infections due to AmpC-Ec (mostly plasmid-mediated) are infrequent in our area. AmpC-Ec-BSI affects mainly patients with intrinsic risk factors and those with previous antibiotic exposure. A high proportion received IET.},
	language = {eng},
	number = {12},
	journal = {European Journal of Clinical Microbiology \& Infectious Diseases: Official Publication of the European Society of Clinical Microbiology},
	author = {Pascual, V. and Alonso, N. and Simó, M. and Ortiz, G. and Garcia, M. C. and Xercavins, M. and Rivera, A. and Morera, M. A. and Miró, E. and Espejo, E. and Navarro, F. and Gurguí, M. and Pérez, J. and Rodríguez-Carballeira, M. and Garau, J. and Calbo, E.},
	year = {2016},
	pmid = {27549108},
	keywords = {Adult, Age Distribution, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacteremia, Bacterial Proteins, Case-Control Studies, DNA, Bacterial, Escherichia coli, Escherichia coli Infections, Female, Humans, Length of Stay, Male, Middle Aged, Polymerase Chain Reaction, Risk Factors, Sequence Analysis, DNA, Severity of Illness Index, Treatment Outcome, beta-Lactamases},
	pages = {1997--2003},
}

@article{kiadaliri_absolute_2016,
	title = {Absolute and relative educational inequalities in obesity among adults in {Tehran}: {Findings} from the {Urban} {HEART} {Study}-2.},
	volume = {10 Suppl 1},
	issn = {1871-403X},
	shorttitle = {Absolute and relative educational inequalities in obesity among adults in {Tehran}},
	doi = {10.1016/j.orcp.2015.05.002},
	abstract = {BACKGROUND: The prevalence of obesity is increasing in Iran. Previous studies showed mixed results in relation to association between socioeconomic status and obesity in the country. The current study aimed to examine educational inequalities among adults in Tehran in 2011.
METHOD: Data on 90,435 persons 18 years and older from Urban Health Equity Assessment and Response Tool (Urban HEART-2) were analyzed. The Slope Index of Inequality (SII) and the Relative Index of Inequality (RII) were used for assessing educational inequalities in obesity. These measures were quantified using generalized linear models for the binomial family adjusted for sex and age. Subgroup analysis was conducted across sex, age groups and the 22 districts of Tehran.
RESULTS: Both SII and RII showed substantial educational inequalities in obesity in favour of more educated adults [RII and SII (95\% CI were equal to 2.91 (2.71-3.11) and 0.12 (0.12-0.13)), respectively]. These educational inequalities were persistent even after adjusting for employment, marital status and smoking. Subgroup analysis revealed that educational inequalities were more profound among women. While among men educational inequalities were generally increasing with age, an inverse trend was observed among women. Educational inequalities were observed within all 22 districts of Tehran and generally there were no statistically significant differences between districts.
CONCLUSION: An inverse association between education and obesity was observed in the current study. To decrease educational inequalities in Tehran, priority should be given to younger women and older men. Further analyses are needed to explain these inequalities.},
	language = {eng},
	journal = {Obesity Research \& Clinical Practice},
	author = {Kiadaliri, Aliasghar A. and Asadi-Lari, Mohsen and Kalantari, Naser and Jafari, Mehdi and Vaez Mahdavi, Mohammad Reza and Faghihzadeh, Soghrat},
	month = sep,
	year = {2016},
	pmid = {26003304},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Educational Status, Educational inequality, Female, Generalized linear model, Humans, Iran, Male, Middle Aged, Obesity, Sex Factors, Social Class, Socioeconomic Factors, Urban-HEART, Young Adult},
	pages = {S57--S63},
}

@article{hirvasniemi_correlation_2016,
	title = {Correlation of {Subchondral} {Bone} {Density} and {Structure} from {Plain} {Radiographs} with {Micro} {Computed} {Tomography} {Ex} {Vivo}},
	volume = {44},
	issn = {1573-9686},
	doi = {10.1007/s10439-015-1452-y},
	abstract = {Osteoarthritis causes changes in the subchondral bone structure and composition. Plain radiography is a cheap, fast, and widely available imaging method. Bone tissue can be well seen from plain radiograph, which however is only a 2D projection of the actual 3D structure. Therefore, the aim was to investigate the relationship between bone density- and structure-related parameters from 2D plain radiograph and 3D bone parameters assessed from micro computed tomography (µCT) ex vivo. Right tibiae from eleven cadavers without any diagnosed joint disease were imaged using radiography and with µCT. Bone density- and structure-related parameters were calculated from four different locations from the radiographs of proximal tibia and compared with the volumetric bone microarchitecture from the corresponding regions. Bone density from the plain radiograph was significantly related with the bone volume fraction (r = 0.86; n = 44; p {\textless} 0.01). Mean homogeneity index for orientation of local binary patterns (HI(angle,mean)) and fractal dimension of vertical structures (FD(Ver)) were related (p {\textless} 0.01) with connectivity density (HI(angle,mean): r = -0.73, FD(Ver): r = 0.69) and trabecular separation (HI(angle,mean): r = 0.73, FD(Ver): r = -0.70) when all ROIs were pooled together (n = 44). Bone density and structure in tibia from standard clinically available 2D radiographs are significantly correlated with true 3D microstructure of bone.},
	language = {eng},
	number = {5},
	journal = {Annals of Biomedical Engineering},
	author = {Hirvasniemi, Jukka and Thevenot, Jérôme and Kokkonen, Harri T. and Finnilä, Mikko A. and Venäläinen, Mikko S. and Jämsä, Timo and Korhonen, Rami K. and Töyräs, Juha and Saarakkala, Simo},
	month = may,
	year = {2016},
	pmid = {26369637},
	pmcid = {PMC4696139},
	keywords = {Adult, Aged, Bone, Bone Density, Female, Humans, Imaging, Three-Dimensional, Male, Micro computed tomography, Middle Aged, Osteoarthritis, Radiography, Structural analysis, Texture analysis, Tibia, X-Ray Microtomography},
	pages = {1698--1709},
}

@article{silverberg_cumulative_2015,
	title = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}: {A} {Cohort} {Study}},
	volume = {163},
	issn = {1539-3704},
	shorttitle = {Cumulative {Incidence} of {Cancer} {Among} {Persons} {With} {HIV} in {North} {America}},
	doi = {10.7326/M14-2768},
	abstract = {BACKGROUND: Cancer is increasingly common among persons with HIV.
OBJECTIVE: To examine calendar trends in cumulative cancer incidence and hazard rate by HIV status.
DESIGN: Cohort study.
SETTING: North American AIDS Cohort Collaboration on Research and Design during 1996 to 2009.
PARTICIPANTS: 86 620 persons with HIV and 196 987 uninfected adults.
MEASUREMENTS: Cancer type-specific cumulative incidence by age 75 years and calendar trends in cumulative incidence and hazard rates, each by HIV status.
RESULTS: Cumulative incidences of cancer by age 75 years for persons with and without HIV, respectively, were as follows: Kaposi sarcoma, 4.4\% and 0.01\%; non-Hodgkin lymphoma, 4.5\% and 0.7\%; lung cancer, 3.4\% and 2.8\%; anal cancer, 1.5\% and 0.05\%; colorectal cancer, 1.0\% and 1.5\%; liver cancer, 1.1\% and 0.4\%; Hodgkin lymphoma, 0.9\% and 0.09\%; melanoma, 0.5\% and 0.6\%; and oral cavity/pharyngeal cancer, 0.8\% and 0.8\%. Among persons with HIV, calendar trends in cumulative incidence and hazard rate decreased for Kaposi sarcoma and non-Hodgkin lymphoma. For anal, colorectal, and liver cancer, increasing cumulative incidence, but not hazard rate trends, were due to the decreasing mortality rate trend (-9\% per year), allowing greater opportunity to be diagnosed. Despite decreasing hazard rate trends for lung cancer, Hodgkin lymphoma, and melanoma, cumulative incidence trends were not seen because of the compensating effect of the declining mortality rate.
LIMITATION: Secular trends in screening, smoking, and viral co-infections were not evaluated.
CONCLUSION: Cumulative cancer incidence by age 75 years, approximating lifetime risk in persons with HIV, may have clinical utility in this population. The high cumulative incidences by age 75 years for Kaposi sarcoma, non-Hodgkin lymphoma, and lung cancer support early and sustained antiretroviral therapy and smoking cessation.},
	language = {eng},
	number = {7},
	journal = {Annals of Internal Medicine},
	author = {Silverberg, Michael J. and Lau, Bryan and Achenbach, Chad J. and Jing, Yuezhou and Althoff, Keri N. and D'Souza, Gypsyamber and Engels, Eric A. and Hessol, Nancy A. and Brooks, John T. and Burchell, Ann N. and Gill, M. John and Goedert, James J. and Hogg, Robert and Horberg, Michael A. and Kirk, Gregory D. and Kitahata, Mari M. and Korthuis, Philip T. and Mathews, William C. and Mayor, Angel and Modur, Sharada P. and Napravnik, Sonia and Novak, Richard M. and Patel, Pragna and Rachlis, Anita R. and Sterling, Timothy R. and Willig, James H. and Justice, Amy C. and Moore, Richard D. and Dubrow, Robert and {North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AIDS}},
	month = oct,
	year = {2015},
	pmid = {26436616},
	pmcid = {PMC4711936},
	keywords = {Adult, Age Distribution, Aged, Anus Neoplasms, Cohort Studies, Colorectal Neoplasms, Comorbidity, Female, HIV Infections, Humans, Incidence, Liver Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Male, Middle Aged, Neoplasms, North America, Proportional Hazards Models, Sarcoma, Kaposi},
	pages = {507--518},
}

@article{svege_exercise_2015,
	title = {Exercise therapy may postpone total hip replacement surgery in patients with hip osteoarthritis: a long-term follow-up of a randomised trial},
	volume = {74},
	issn = {1468-2060},
	shorttitle = {Exercise therapy may postpone total hip replacement surgery in patients with hip osteoarthritis},
	doi = {10.1136/annrheumdis-2013-203628},
	abstract = {BACKGROUND: Exercise treatment is recommended for all patients with hip osteoarthritis (OA), but its effect on the long-term need for total hip replacement (THR) is unknown.
METHODS: We conducted a long-term follow-up of a randomised trial investigating the efficacy of exercise therapy and patient education versus patient education only on the 6-year cumulative survival of the native hip to THR in 109 patients with symptomatic and radiographic hip OA. Results regarding the primary outcome measure of the trial, self-reported pain at 16 months follow-up, have been reported previously.
RESULTS: There were no group differences at baseline. The response rate at follow-up was 94\%. 22 patients in the group receiving both exercise therapy and patient education and 31 patients in the group receiving patient education only underwent THR during the follow-up period, giving a 6-year cumulative survival of the native hip of 41\% and 25\%, respectively (p=0.034). The HR for survival of the native hip was 0.56 (CI 0.32 to 0.96) for the exercise therapy group compared with the control group. Median time to THR was 5.4 and 3.5 years, respectively. The exercise therapy group had better self-reported hip function prior to THR or end of study, but no significant differences were found for pain and stiffness.
CONCLUSIONS: Our findings in this explanatory study suggest that exercise therapy in addition to patient education can reduce the need for THR by 44\% in patients with hip OA. ClinicalTrials.gov number NCT00319423 (original project protocol) and NCT01338532 (additional protocol for long-term follow-up).},
	language = {eng},
	number = {1},
	journal = {Annals of the Rheumatic Diseases},
	author = {Svege, Ida and Nordsletten, Lars and Fernandes, Linda and Risberg, May Arna},
	month = jan,
	year = {2015},
	pmid = {24255546},
	pmcid = {PMC4283660},
	keywords = {Aged, Arthroplasty, Replacement, Hip, Exercise Therapy, Female, Follow-Up Studies, Humans, Male, Middle Aged, Orthopedic Surgery, Osteoarthritis, Osteoarthritis, Hip, Patient Education as Topic, Physcial therapy, Rehabilitation, Time Factors},
	pages = {164--169},
}

@article{
 title = {Quality of life in older people with dementia: a multilevel study of individual attributes and residential care center characteristics},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 keywords = {Aged,Aged, 80 and over,Cross-Sectional Studies,Dementia/epidemiology/psychology,Female,Health Status,Humans,Institutionalization,Male,Middle Aged,Nursing Homes,Quality of Life,Questionnaires,Retrospective Studies,Spain/epidemiology,dementia,multilevel analysis,older adults,residential care centers},
 pages = {104-110},
 volume = {15},
 month = {1},
 publisher = {Japan Geriatrics Society},
 city = {Department "G.F. Ingrassia", Hygiene and Public Health, University of Catania, Catania, Italy; National School of Public Health, Carlos III Institute of Health, Madrid, Spain.},
 id = {35f0e744-a287-3daf-8594-25c38c57ad04},
 created = {2016-08-20T16:52:14.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {CI: (c) 2014; JID: 101135738; OTO: NOTNLM; 2013/12/10 [accepted]; 2014/01/24 [aheadofprint]; ppublish},
 folder_uuids = {f1983289-bfcc-4bbc-aa58-64df97457698},
 private_publication = {false},
 abstract = {AIM: To analyze how the characteristics of institutionalized older people with dementia and residential care centers are associated with the individual's quality of life (QoL). METHODS: Data were collected from a survey carried out on 525 elderly people aged 60 years or older in 14 nursing care homes across Spain. Multilevel linear analysis to assess the differences in QoL level between centers and individuals was carried out. RESULTS: The characteristics of the individuals that were associated with a higher QoL were functional independence, health status and gathering with family, friends or neighbors. In contrast, higher levels of dementia, depression and the length of institutionalization had a negative effect on QoL. In relation to the residential care center characteristics, the availability of geriatricians was associated with higher QoL, compared with those centers with no geriatricians on staff. In addition, public centers (public ownership and publicly-funded residents) were also associated with higher QoL than private/mixed centers. The multilevel analysis showed that the 16.4% of the differences in QoL was related to residence factors. CONCLUSION: These results reflect the importance of the functional, social, mental and residential dimensions in the QoL of older adults with dementia. Actions devoted to improving these key dimensions would contribute to promote the well-being of this vulnerable population.},
 bibtype = {article},
 author = {Marventano, S and Prieto-Flores, M E and Sanz-Barbero, B and Martin-Garcia, S and Fernandez-Mayoralas, G and Rojo-Perez, F and Martinez-Martin, P and Forjaz, M J and Ageing, Spanish Research Group on Quality of Life and},
 journal = {Geriatrics & gerontology international},
 number = {1}
}

@article{hippisley-cox_performance_2014,
	title = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice: a validation study},
	volume = {4},
	issn = {2044-6055},
	shorttitle = {The performance of seven {QPrediction} risk scores in an independent external sample of patients from general practice},
	doi = {10.1136/bmjopen-2014-005809},
	abstract = {OBJECTIVES: To validate the performance of a set of risk prediction algorithms developed using the QResearch database, in an independent sample from general practices contributing to the Clinical Research Data Link (CPRD).
SETTING: Prospective open cohort study using practices contributing to the CPRD database and practices contributing to the QResearch database.
PARTICIPANTS: The CPRD validation cohort consisted of 3.3 million patients, aged 25-99 years registered at 357 general practices between 1 Jan 1998 and 31 July 2012. The validation statistics for QResearch were obtained from the original published papers which used a one-third sample of practices separate to those used to derive the score. A cohort from QResearch was used to compare incidence rates and baseline characteristics and consisted of 6.8 million patients from 753 practices registered between 1 Jan 1998 and until 31 July 2013.
OUTCOME MEASURES: Incident events relating to seven different risk prediction scores: QRISK2 (cardiovascular disease); QStroke (ischaemic stroke); QDiabetes (type 2 diabetes); QFracture (osteoporotic fracture and hip fracture); QKidney (moderate and severe kidney failure); QThrombosis (venous thromboembolism); QBleed (intracranial bleed and upper gastrointestinal haemorrhage). Measures of discrimination and calibration were calculated.
RESULTS: Overall, the baseline characteristics of the CPRD and QResearch cohorts were similar though QResearch had higher recording levels for ethnicity and family history. The validation statistics for each of the risk prediction scores were very similar in the CPRD cohort compared with the published results from QResearch validation cohorts. For example, in women, the QDiabetes algorithm explained 50\% of the variation within CPRD compared with 51\% on QResearch and the receiver operator curve value was 0.85 on both databases. The scores were well calibrated in CPRD.
CONCLUSIONS: Each of the algorithms performed practically as well in the external independent CPRD validation cohorts as they had in the original published QResearch validation cohorts.},
	language = {eng},
	number = {8},
	journal = {BMJ open},
	author = {Hippisley-Cox, Julia and Coupland, Carol and Brindle, Peter},
	year = {2014},
	pmid = {25168040},
	pmcid = {PMC4156807},
	keywords = {Adult, Aged, Aged, 80 and over, Algorithms, Calibration, Cardiovascular Diseases, Cprd, Ethnic Groups, Family, Female, General Practice, Hemorrhage, Humans, Kidney Diseases, Male, Middle Aged, Osteoporotic Fractures, Prognosis, Prospective Studies, QResearch, Qrisk2, Risk, Validation, Venous Thromboembolism, diabetes mellitus},
	pages = {e005809}
}

@article{
 title = {How much do residential aged care staff members know about the nutritional needs of residents?},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Attitude of Health Personnel,Cross-Sectional Studies,Dementia/nursing,Female,Geriatric Nursing/methods,Health Care Surveys,Health Knowledge, Attitudes, Practice,Humans,Male,Malnutrition/nursing,Meals,Middle Aged,Nursing Staff,Nutrition Assessment,Quality of Life/psychology,Residential Facilities,malnutrition,mealtime practices,nutrition knowledge,old age,residential care,staff},
 pages = {54-64},
 volume = {9},
 month = {3},
 publisher = {Blackwell Publishing Ltd},
 city = {Dementia Collaborative Research Centre: Carers & Consumers, Queensland University of Technology, Brisbane, Australia; Dementia Training Studies Centre, Queensland University of Technology, Brisbane, Australia; School of Nursing, Queensland University of T},
 id = {ddcbb97d-cbf9-341d-982c-c02ae2ebd52c},
 created = {2016-08-20T16:52:30.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {ID: 74113; CI: (c) 2013; JID: 101267281; OTO: NOTNLM; 2012/08/03 [received]; 2012/11/21 [accepted]; 2013/02/11 [aheadofprint]; ppublish},
 folder_uuids = {06271a48-ad48-43cc-b073-52e57f10f5e1},
 private_publication = {false},
 abstract = {BACKGROUND: Undernutrition, weight loss and dehydration are major clinical issues for people with dementia in residential care, with excessive weight loss contributing to increased risk of frailty, immobility, illness and premature morbidity. This paper discusses a nutritional knowledge and attitudes survey conducted as part of a larger project focused on improving nutritional intake of people with dementia within a residential care facility in Brisbane, Australia. AIMS: The specific aims of the survey were to identify (i) knowledge of the nutritional needs of aged care facility residents; (ii) mealtime practices; and (iii) attitudes towards mealtime practices and organisation. METHODS: A survey based on those used in other healthcare settings was completed by 76 staff members. The survey included questions about nutritional knowledge, opinions of the food service, frequency of feeding assistance provided and feeding assessment practices. RESULTS: Nutritional knowledge scores ranged from 1 to 9 of a possible 10, with a mean score of 4.67. While 76% of respondents correctly identified risk factors associated with malnutrition in nursing home residents, only 38% of participants correctly identified the need for increased protein and energy in residents with pressure ulcers, and just 15% exhibited correct knowledge of fluid requirements. Further, while nutritional assessment was considered an important part of practice by 83% of respondents, just 53% indicated that they actually carried out such assessments. Identified barriers to promoting optimal nutrition included insufficient time to observe residents (56%); being unaware of residents' feeding issues (46%); poor knowledge of nutritional assessments (44%); and unappetising appearance of food served (57%). CONCLUSION: An important step towards improving health and quality of life for residents of aged care facilities would be to enhance staff nutritional awareness and assessment skills. This should be carried out through increased attention to both preservice curricula and on-the-job training. IMPLICATIONS FOR PRACTICE: The residential facility staff surveyed demonstrated low levels of nutrition knowledge, which reflects findings from the international literature. This has implications for the provision of responsive care to residents of these facilities and should be explored further.},
 bibtype = {article},
 author = {Beattie, E and O'Reilly, M and Strange, E and Franklin, S and Isenring, E},
 journal = {International journal of older people nursing},
 number = {1}
}

@article{wiwatanadate_acute_2014,
	title = {Acute air pollution-related symptoms among residents in {Chiang} {Mai}, {Thailand}},
	volume = {76},
	issn = {0022-0892},
	abstract = {Open burnings (forest fires, agricultural, and garbage burnings) are the major sources of air pollution in Chiang Mai, Thailand. A time series prospective study was conducted in which 3025 participants were interviewed for 19 acute symptoms with the daily records of ambient air pollutants: particulate matter less than 10 microm in size (PM10), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3). PM10 was positively associated with blurred vision with an adjusted odds ratio (OR) of 1.009. CO was positively associated with lower lung and heart symptoms with adjusted ORs of 1.137 and 1.117. NO2 was positively associated with nosebleed, larynx symptoms, dry cough, lower lung symptoms, heart symptoms, and eye irritation with the range of adjusted ORs (ROAORs) of 1.024 to 1.229. SO2 was positively associated with swelling feet, skin symptoms, eye irritation, red eyes, and blurred vision with ROAORs of 1.205 to 2.948. Conversely, O3 was negatively related to running nose, burning nose, dry cough, body rash, red eyes, and blurred vision with ROAORs of 0.891 to 0.979.},
	language = {eng},
	number = {6},
	journal = {Journal of Environmental Health},
	author = {Wiwatanadate, Phongtape},
	month = feb,
	year = {2014},
	pmid = {24645417},
	note = {00003 },
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Environmental Exposure, Female, Humans, Male, Middle Aged, Odds Ratio, Particulate Matter, Prospective Studies, Respiration Disorders, Thailand, Weather},
	pages = {76--84}
}

@article{
 title = {Living in uncertain times: trajectories to death in residential care homes},
 type = {article},
 year = {2014},
 identifiers = {[object Object]},
 keywords = {Advance Care Planning/organization & administratio,Aged,Aged, 80 and over,Attitude of Health Personnel,England/epidemiology,Frail Elderly,Health Services Research,Homes for the Aged/organization & administration,Hospitalization,Humans,Nursing Homes,Policy Making,Primary Health Care,Professional-Patient Relations,Prospective Studies,Qualitative Research,Terminal Care/organization & administration,care homes,dying trajectories,end-of-life care,palliative care},
 pages = {e576-83},
 volume = {64},
 month = {9},
 city = {Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge.; International Observatory on End of Life Care, Faculty of Health and Medicine, Lancaster University, Lancaster.; Primary Care Unit, Department of Public },
 id = {5fd4a42e-17f3-3187-820a-582da2218f36},
 created = {2016-08-20T16:52:36.000Z},
 file_attached = {false},
 profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597},
 group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4},
 last_modified = {2017-03-14T09:54:45.334Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {CI: (c) British Journal of General Practice 2014; JID: 9005323; OID: NLM: PMC4141615; OTO: NOTNLM; ppublish},
 folder_uuids = {cbf07968-bdea-492d-b4e4-d50a2e1cb62d},
 private_publication = {false},
 abstract = {BACKGROUND: Older people living in care homes often have limited life expectancy. Practitioners and policymakers are increasingly questioning the appropriateness of many acute hospital admissions and the quality of end-of-life care provided in care homes. AIM: To describe care home residents' trajectories to death and care provision in their final weeks of life. DESIGN AND SETTING: Prospective study of residents in six residential care homes in three sociodemographically varied English localities: Hertfordshire, Essex, and Cambridgeshire. METHOD: Case note reviews and interviews with residents, care home staff, and healthcare professionals. RESULTS: Twenty-three out of 121 recruited residents died during the study period. Four trajectories to death were identified: 'anticipated dying' with an identifiable end-of-life care period and death in the care home (n = 9); 'unexpected dying' with death in the care home that was not anticipated and often sudden (n = 3); 'uncertain dying' with a period of diagnostic uncertainty or difficult symptom management leading to hospital admission and inpatient death (n = 7); and 'unpredictable dying' with an unexpected event leading to hospital admission and inpatient death (n = 4). End-of-life care tools were rarely used. Most residents who had had one or more acute hospital admission were still alive at the end of the study. CONCLUSION: For some care home residents there was an identifiable period when they were approaching the end-of-life and planned care was put in place. For others, death came unexpectedly or during a period of considerable uncertainty, with care largely unplanned and reactive to events.},
 bibtype = {article},
 author = {Barclay, S and Froggatt, K and Crang, C and Mathie, E and Handley, M and Iliffe, S and Manthorpe, J and Gage, H and Goodman, C},
 journal = {The British journal of general practice : the journal of the Royal College of General Practitioners},
 number = {626}
}

Paper  doi  abstract   bibtex   

@article{aboukais_surgery_2014,
	title = {Surgery followed by radiosurgery: a deliberate valuable strategy in the treatment of intracranial meningioma},
	volume = {124},
	issn = {1872-6968 (Electronic) 0303-8467 (Linking)},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25043442},
	doi = {10.1016/j.clineuro.2014.06.035},
	abstract = {OBJECTIVE: The aim of our study is to show that surgery followed by Gamma Knife Radiosurgery is an effective and safe combined treatment for the control of intracranial meningiomas located close to critical structures. MATERIALS AND METHODS: This retrospective study followed 31 patients with intracranial meningioma between 2005 and 2010. We included patients when initial therapeutic decision was deliberate subtotal surgical resection preparing a target for early postoperative GKR. Early MRI was performed to evaluate the tumor residual volume after surgical procedure. Annual MRI was performed to detect any tumor progression. RESULTS: The mean follow-up was 4.5 years. The mean margin dose was 14.5 Gy and the mean target volume was 2.4 cm3. The mean progression free survival after combined treatment was 4.4 years in the irradiated target volume and 3.9 years on the limit or remotely of irradiated target volume. Of all patients, we recorded 5 tumor progressions after combined treatment, in-field in 1 case and out-of-field in 4 cases. All tumor progressions were high-grade meningiomas. CONCLUSION: Surgery followed by radiosurgery is a safe and effective combined treatment for intracranial meningiomas. We recommend it in case of meningioma located close to critical structures for which it is safer to leave in place a tumor remnant to reduce morbidity.},
	journal = {Clin Neurol Neurosurg},
	author = {Aboukais, R. and Zairi, F. and Reyns, N. and Le Rhun, E. and Touzet, G. and Blond, S. and Lejeune, J. P.},
	month = sep,
	year = {2014},
	keywords = {*Neoplasm Recurrence, Adult, Aged, Disease-Free Survival, Female, Humans, Local, Male, Meningeal Neoplasms/*surgery, Meningioma/*surgery, Middle Aged, Neurosurgical Procedures/*methods, Radiosurgery/*methods, Retrospective Studies, Treatment Outcome},
	pages = {123--6},
}

Website  abstract   bibtex   

@article{
 title = {Dynamic data during hypotensive episode improves mortality predictions among patients with sepsis and hypotension.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {80 and over,Adult,Aged,Algorithms,Cohort Studies,Comorbidity,Critical Illness,Critical Illness: mortality,Female,Great Britain,Hospital Mortality,Hospital Mortality: trends,Humans,Hypotension,Hypotension: mortality,Intensive Care Units,Male,Middle Aged,Outcome Assessment (Health Care),Predictive Value of Tests,Prognosis,Retrospective Studies,Sepsis,Sepsis: mortality},
 pages = {954-62},
 volume = {41},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3609896&tool=pmcentrez&rendertype=abstract},
 month = {4},
 publisher = {NIH Public Access},
 id = {95d7042f-e668-3f25-aeb3-4f00b98dda28},
 created = {2016-03-29T18:26:56.000Z},
 file_attached = {false},
 profile_id = {304786e8-5116-360a-80be-e62833097578},
 group_id = {d7b44578-07c1-3210-ae74-3bcd7f980767},
 last_modified = {2017-03-14T15:45:25.917Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Mayaud_Crit_Care_April_2013},
 source_type = {article},
 private_publication = {false},
 abstract = {OBJECTIVES: To determine if a prediction rule for hospital mortality using dynamic variables in response to treatment of hypotension in patients with sepsis performs better than current models.\n\nDESIGN: Retrospective cohort study.\n\nSETTING: All ICUs at a tertiary care hospital.\n\nPATIENTS: Adult patients admitted to ICUs between 2001 and 2007 of whom 2,113 met inclusion criteria and had sufficient data.\n\nINTERVENTIONS: None.\n\nMEASUREMENTS AND MAIN RESULTS: We developed a prediction algorithm for hospital mortality in patients with sepsis and hypotension requiring medical intervention using data from the Multiparameter Intelligent Monitoring in Intensive Care II. We extracted 189 candidate variables, including treatments, physiologic variables and laboratory values collected before, during, and after a hypotensive episode. Thirty predictors were identified using a genetic algorithm on a training set (n=1500) and validated with a logistic regression model on an independent validation set (n=613). The final prediction algorithm used included dynamic information and had good discrimination (area under the receiver operating curve=82.0%) and calibration (Hosmer-Lemeshow C statistic=10.43, p=0.06). This model was compared with Acute Physiology and Chronic Health Evaluation IV using reclassification indices and was found to be superior with an Net Reclassification Improvement of 0.19 (p<0.001) and an Integrated Discrimination Improvement of 0.09 (p<0.001).\n\nCONCLUSIONS: Hospital mortality predictions based on dynamic variables surrounding a hypotensive event is a new approach to predicting prognosis. A model using these variables has good discrimination and calibration and offers additional predictive prognostic information beyond established ones.},
 bibtype = {article},
 author = {Mayaud, Louis and Lai, Peggy S and Clifford, Gari D and Tarassenko, Lionel and Celi, Leo Anthony and Annane, Djillali},
 journal = {Critical Care Medicine},
 number = {4}
}

Paper  abstract   bibtex   

@article{
 title = {A multi-center retrospective analysis of treatment effects and quality of life in adult patients with cranial ependymomas},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Brain Neoplasms,Brain Neoplasms: mortality,Brain Neoplasms: pathology,Brain Neoplasms: therapy,Combined Modality Therapy,Cranial Irradiation,Ependymoma,Ependymoma: mortality,Ependymoma: pathology,Ependymoma: therapy,Female,Follow-Up Studies,Humans,Male,Middle Aged,Neurosurgical Procedures,Prognosis,Quality of Life,Retrospective Studies,Survival Rate,Young Adult},
 pages = {319-27},
 volume = {114},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/23813228},
 month = {9},
 id = {f45c71d6-e421-3cd5-8da7-0d79c822397d},
 created = {2014-04-16T20:14:36.000Z},
 accessed = {2014-04-16},
 file_attached = {true},
 profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T21:45:19.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Long term quality of life data of adult patients harboring intracranial ependymomas have not been reported. The role of adjuvant radiation therapy in Grade II ependymomas is unclear and differs from study to study. We therefore sought to retrospectively analyze outcome and quality of life of adult patients that were operated on intracranial ependymomas at four different surgical centers in two countries. All patients were attempted to be contacted via telephone to assess quality of life (QoL) at the time of the telephone interview. The standard EORTC QoL Questionnaire C30 (EORTC QLQ-C30) and the EORTC QLQ-Brain Cancer Module (QLQ-BN20) were used. 64 adult patients with intracranial ependymomas were included in the study. The only factor that was associated with increased survival was age <55 years (p < 0.001). Supratentorial location was correlated with shorter progression free survival than infratentorial location (PFS; p = 0.048). In WHO Grade II tumors local irradiation did not lead to increased PFS (p = 0.888) or overall survival (p = 0.801). Even for incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS (p = 0.911). In a multivariate analysis of QoL, irradiated patients had significantly worse scores in the item "fatigue" (p = 0.037) than non-irradiated patients. Here we present QoL data of adult patients with intracranial ependymomas. Our data show that local radiation therapy may have long-term effects on patients' QoL. Since in the incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS in this retrospective study, prospective randomized studies are necessary. In addition to age, supratentorial tumor location is associated with a worse prognosis in adult ependymoma patients.},
 bibtype = {article},
 author = {Dützmann, Stephan and Schatlo, Bawarjan and Lobrinus, Alexander and Murek, Michael and Wostrack, Maria and Weiss, Carolin and Schaller, Karl and Raabe, Andreas and Meyer, Bernhard and Goldbrunner, Roland and Franz, Kea and Seifert, Volker and Senft, Christian},
 journal = {Journal of Neuro-Oncology},
 number = {3}
}

Website  abstract   bibtex   

@article{
 title = {Dedicated orthopedic operating room unit improves operating room efficiency},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {*Arthroplasty, Replacement, Hip,*Arthroplasty, Replacement, Knee,*Operating Rooms/og [Organization & Administration,*Process Assessment (Health Care),Aged,Chi-Square Distribution,Comorbidity,Efficiency, Organizational,Female,Humans,Logistic Models,Male,Middle Aged,Operative Time,Propensity Score,Retrospective Studies,Time Management},
 pages = {1066-1071.e2},
 volume = {28},
 websites = {http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=23540542},
 id = {8091b854-98a0-398e-98d0-e184b2c6c718},
 created = {2019-03-19T15:08:10.483Z},
 file_attached = {false},
 profile_id = {59e4d4d9-485f-3c31-ad40-2ced068886ad},
 group_id = {e95745c0-49e9-3434-b20f-63583e8a5d27},
 last_modified = {2019-04-08T15:08:01.163Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 source_type = {Journal Article},
 language = {English},
 notes = {Small, Travis J
Gad, Bishoy V
Klika, Alison K
Mounir-Soliman, Loran S
Gerritsen, Ryan L
Barsoum, Wael K
S0883-5403(13)00160-5},
 folder_uuids = {f8a142dd-eb80-496b-b5d6-fb6d3b05d3d1},
 private_publication = {false},
 abstract = {We investigated the effectiveness of dedicated orthopedic operating rooms (OR) on minimizing time spent on perioperative processes to increase OR throughput in total knee and hip arthroplasty procedures. The use of a dedicated orthopedic unit that included 6 ORs with staff allocated only for those ORs was compared to the use of a traditional staffing model. After matching to simulate randomization, each group consisted of 422 procedures. The dedicated orthopedic unit improved average anesthesia controlled time by 4 minutes (P<.001), operative time by 7 minutes (P=.004) and turnover time by 8 minutes (P<.001). An overall improvement of 19 minutes per procedure using the dedicated unit was observed. Utilizing a dedicated orthopedic unit can save time without increasing adverse events.Copyright © 2013 Elsevier Inc. All rights reserved.},
 bibtype = {article},
 author = {Small, T J and Gad, B V and Klika, A K and Mounir-Soliman, L S and Gerritsen, R L and Barsoum, W K},
 journal = {Journal of Arthroplasty},
 number = {7}
}

@article{becquemont_national_2013,
	title = {National observatory on the therapeutic management in ambulatory care patients aged 65 and over, with type 2 diabetes, chronic pain or atrial fibrillation},
	volume = {68},
	issn = {0040-5957},
	doi = {10.2515/therapie/2013043},
	abstract = {The primary objective of the S.AGES cohort is to describe the real-life therapeutic care of elderly patients. Patients and methods. This is a prospective observational cohort study of 3 700 non-institutionalized patients over the age of 65 years with either type 2 diabetes mellitus (T2DM), chronic pain or atrial fibrillation (AF) recruited by French general practitioners (GPs). Follow-up is planned for 3 years. Baseline characteristics. In the chronic pain sub-cohort, 33\% of patients are treated with only grade 1 analgesics, 29\% with grade 2 analgesics and 3\% with grade 3 analgesics, and 22\% have no pain treatment. In the T2DM sub-cohort, 61\% of patients have well-controlled diabetes (Hb1c{\textless}7\%) and 18\% are treated with insulin. In the AF sub-cohort, 65\% of patients have a CHADS2 score greater than 2, 77\% are treated with oral anticoagulants, 17\% with platelet inhibitors, 40\% with antiarrhythmic drugs and 56\% with rate slowing medications. Conclusion. The S.AGES cohort presents a unique opportunity to clarify the real-life therapeutic management of ambulatory elderly subjects and will help to identify the factors associated with the occurrence of major clinical events.},
	language = {eng},
	number = {4},
	journal = {Therapie},
	author = {Becquemont, Laurent and Benattar-Zibi, Linda and Bertin, Philippe and Berrut, Gilles and Corruble, Emmanuelle and Danchin, Nicolas and Delespierre, Tiba and Derumeaux, Geneviève and Falissard, Bruno and Forette, Francoise and Hanon, Olivier and Pasquier, Florence and Pinget, Michel and Ourabah, Rissane and Piedvache, Céline and {S.AGES investigators}},
	month = aug,
	year = {2013},
	pmid = {23981265},
	keywords = {Aged, Humans, Female, Male, Aged, 80 and over, Cohort Studies, France, Ambulatory Care, Atrial Fibrillation, Chronic Pain, Diabetes Mellitus, Type 2, Residence Characteristics},
	pages = {265--283}
}

@article{tan_identification_2013,
	title = {Identification of a new cyclovirus in cerebrospinal fluid of patients with acute  central nervous system infections.},
	volume = {4},
	issn = {2150-7511},
	doi = {10.1128/mBio.00231-13},
	abstract = {Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4\% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58\%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus.},
	language = {eng},
	number = {3},
	journal = {mBio},
	author = {Tan, Le Van and van Doorn, H. Rogier and Nghia, Ho Dang Trung and Chau, Tran Thi Hong and Tu, Le Thi Phuong and de Vries, Michel and Canuti, Marta and Deijs, Martin and Jebbink, Maarten F. and Baker, Stephen and Bryant, Juliet E. and Tham, Nguyen Thi and BKrong, Nguyen Thi Thuy Chinh and Boni, Maciej F. and Loi, Tran Quoc and Phuong, Le Thi and Verhoeven, Joost T. P. and Crusat, Martin and Jeeninga, Rienk E. and Schultsz, Constance and Chau, Nguyen Van Vinh and Hien, Tran Tinh and van der Hoek, Lia and Farrar, Jeremy and de Jong, Menno D.},
	month = jun,
	year = {2013},
	pmid = {23781068},
	pmcid = {PMC3684831},
	keywords = {Adolescent, Adult, Aged, Animals, Central Nervous System Infections/epidemiology/*virology, Child, Child, Preschool, Circoviridae Infections/epidemiology/*virology, Circoviridae/*classification/genetics/*isolation \& purification, Cluster Analysis, DNA, Viral/chemistry/genetics, Female, Genome, Viral, Humans, Infant, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Prevalence, Prospective Studies, Sequence Analysis, DNA, Vietnam, Young Adult},
	pages = {e00231--00213},
}

@article{theophile_comparison_2013,
	title = {Comparison of three methods (an updated logistic probabilistic method, the {Naranjo} and {Liverpool} algorithms) for the evaluation of routine pharmacovigilance case reports using consensual expert judgement as reference},
	volume = {36},
	issn = {1179-1942},
	doi = {10.1007/s40264-013-0083-1},
	abstract = {BACKGROUND: An updated probabilistic causality assessment method and the Liverpool algorithm presented as an improved version of the Naranjo algorithm, one of the most used and accepted causality assessment methods, have recently been proposed.
OBJECTIVE: In order to test the validity of the probabilistic method in routine pharmacovigilance, results provided by the Naranjo and Liverpool algorithms, as well as the updated probabilistic method, were each compared with a consensual expert judgement taken as reference.
METHODS: A sample of 59 drug-event pairs randomly sampled from spontaneous reports to the French pharmacovigilance system was assessed by expert judgement until reaching consensus and by members of a pharmacovigilance unit using the updated probabilistic method, the Naranjo and Liverpool algorithms. Probabilities given by the probabilistic method, and categories obtained by both the Naranjo and the Liverpool algorithms were compared as well as their sensitivity, specificity, positive and negative predictive values.
RESULTS: The median probability for drug causation given by the consensual expert judgement was 0.70 (inter-quartile range, IQR 0.54-0.84) versus 0.77 (IQR 0.54-0.91) for the probabilistic method. For the Naranjo algorithm, the 'possible' causality category was predominant (61 \%), followed by 'probable' (35 \%), 'doubtful', and 'almost certain' categories (2 \% each). Category distribution obtained with the Liverpool algorithm was similar to that obtained by the Naranjo algorithm with a majority of 'possible' (61 \%) and 'probable' (30 \%) followed by 'definite' (7 \%) and 'unlikely' (2 \%). For the probabilistic method, sensitivity, specificity, positive and negative predictive values were 0.96, 0.56, 0.92 and 0.71, respectively. For the Naranjo algorithm, depending on whether the 'possible' category was considered in favour or in disfavour of drug causation, sensitivity was, respectively, 1 or 0.42, specificity 0.11 or 0.89, negative predictive value 1 or 0.22 and positive predictive value 0.86 or 0.95; results were identical for the Liverpool algorithm.
CONCLUSION: The logistic probabilistic method gave results closer to the consensual expert judgment than either the Naranjo or Liverpool algorithms whose performance were strongly dependent on the meaning given to the 'possible' category. Owing to its good sensitivity and positive predictive value and by providing results as continuous probabilities, the probabilistic method seems worthy to use for a trustable assessment of adverse drug reactions in routine practice.},
	language = {eng},
	number = {10},
	journal = {Drug Safety},
	author = {Théophile, Hélène and André, Manon and Miremont-Salamé, Ghada and Arimone, Yannick and Bégaud, Bernard},
	month = oct,
	year = {2013},
	pmid = {23828659},
	keywords = {Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Algorithms, Child, Preschool, Consensus, Drug-Related Side Effects and Adverse Reactions, Expert Testimony, Female, France, Humans, Infant, Judgment, Logistic Models, Male, Middle Aged, Pharmaceutical Preparations, Pharmacovigilance, Sensitivity and Specificity},
	pages = {1033--1044}
}

@article{jameson_impact_2013,
	title = {Impact of lipid-lowering therapy on the prevalence of dyslipidaemia in patients at high-risk of cardiovascular events in {UK} primary care - a retrospective database study},
	volume = {67},
	issn = {1742-1241},
	doi = {10.1111/ijcp.12238},
	abstract = {AIMS: To estimate the prevalence of dyslipidaemias in high-risk patients new to lipid-modifying therapy (LMT), and establish the extent to which these lipid abnormalities are addressed by treatment in UK clinical practice.
METHODS: The PRIMULA study was a retrospective analysis, conducted using the UK General Practice Research Database. Two periods were studied as follows: a pretreatment period, defined as the 12 months before initiation of LMT (the index date), and a follow-up period of at least 12 months. Patients included in the study (n = 25,011) had dyslipidaemia with at least one abnormal lipid measurement [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) or triglycerides (TG)] in the pretreatment period. All patients were at high risk of cardiovascular events, which was defined as having a history of cardiovascular disease, a 10-year Framingham risk score higher than 20\%, diabetes or hypertension, as defined by the Joint British Societies 2 guidelines.
RESULTS: At the index date, 98\% of patients were initiated on statin monotherapy. After 12 months of treatment, 15.2\% (sub-group range: 11.0-22.9\%) of all high-risk patients had no lipid abnormalities. The proportions of patients with high TC or LDL-C levels decreased from 98.8\% to 68.9\%, and from 99.2\% to 68.7\%, respectively, over 12 months. The prevalence of high TG levels decreased from 45.0\% to 26.9\%, whereas that of low HDL-C levels increased, from 16.6\% to 18.0\%. Risk factors for cardiovascular events were not consistently associated with the likelihood of attaining optimal lipid levels.
CONCLUSIONS: Despite widespread use of statins, many individuals at high risk of cardiovascular events have persistently abnormal lipid levels, with over two-thirds of patients not achieving target levels of LDL-C or TC. Management of dyslipidaemia is therefore suboptimal in this important high-risk group in UK standard practice.},
	language = {eng},
	number = {12},
	journal = {International Journal of Clinical Practice},
	author = {Jameson, K. and Amber, V. and D'Oca, K. and Mills, D. and Giles, A. and Ambegaonkar, B.},
	month = dec,
	year = {2013},
	pmid = {23944233},
	pmcid = {PMC4232237},
	keywords = {Adult, Aged, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, LDL, Cross-Sectional Studies, Dyslipidemias, Female, Great Britain, Humans, Hypolipidemic Agents, Male, Middle Aged, Prevalence, Retrospective Studies, Risk Factors},
	pages = {1228--1237}
}

@article{zhao_efficacy_2013,
	title = {Efficacy of extracorporeal shockwave therapy for knee osteoarthritis: a randomized controlled trial},
	volume = {185},
	issn = {1095-8673},
	shorttitle = {Efficacy of extracorporeal shockwave therapy for knee osteoarthritis},
	doi = {10.1016/j.jss.2013.07.004},
	abstract = {BACKGROUND: Extracorporeal shockwave therapy (ESWT) has been widely used for pain relief and treatment of musculoskeletal disorders. We aimed to assess ESWT for knee osteoarthritis (OA) over 12 wk by comparison with placebo treatment.
MATERIALS AND METHODS: We randomized 70 patients to receive placebo (n = 36) or ESWT (n = 34). For ESWT, patients received 4000 pulses of shockwave at 0.25 mJ/mm(2) weekly for 4 wk. In the placebo group, patients received shockwave at 0 mJ/mm(2) in the same area. The effect on OA was assessed by pain on a visual analog scale and disability on the Lequesne index, Western Ontario and McMaster University Osteoarthritis Index, and patient perception of the clinical severity of OA. Evaluation was performed at baseline and after 1, 4, and 12 wk.
RESULTS: We found no adverse events during and after ESWT. ESWT was more effective than placebo in reducing pain on movement at each period (P {\textless} 0.01). The mean visual analog scale score with ESWT was 3.83 at 12 wk versus 7.56 at baseline (P {\textless} 0.01). The Lequesne index and the Western Ontario and McMaster University Osteoarthritis Index score were reduced with ESWT. Moreover, patient perception of clinical severity of OA was significantly greater with ESWT than that with placebo (P {\textless} 0.01).
CONCLUSIONS: ESWT is effective in reducing pain and improving knee function, with better results than placebo during the 12-wk treatment. However, further pilot studies are needed to determine whether ESWT should be recommended at an early or later stage of OA or combined with conventional therapies.},
	language = {eng},
	number = {2},
	journal = {The Journal of Surgical Research},
	author = {Zhao, Zhe and Jing, Rufang and Shi, Zhan and Zhao, Bin and Ai, Quan and Xing, Gengyan},
	month = dec,
	year = {2013},
	pmid = {23953895},
	keywords = {Aged, Arthralgia, Extracorporeal shockwave therapy, Female, High-Energy Shock Waves, Humans, Knee, Knee Joint, Male, Middle Aged, Osteoarthritis, Osteoarthritis, Knee, Placebos, Prospective Studies, Recovery of Function, Rehabilitation, Single-Blind Method, Treatment Outcome},
	pages = {661--666}
}

@article{ganten_role_2013,
	title = {The role of perfusion effects in monitoring of chemoradiotherapy of rectal carcinoma using diffusion-weighted imaging},
	volume = {13},
	issn = {1470-7330},
	doi = {10.1102/1470-7330.2013.0045},
	abstract = {PURPOSE: The aim of this study was to characterize and understand the therapy-induced changes in diffusion parameters in rectal carcinoma under chemoradiotherapy (CRT). The current literature shows conflicting results in this regard. We applied the intravoxel incoherent motion model, which allows for the differentiation between diffusion (D) and perfusion (f) effects, to further elucidate potential underlying causes for these divergent reports.
MATERIALS AND METHODS: Eighteen patients with primary rectal carcinoma undergoing preoperative CRT were examined before, during, and after neoadjuvant CRT using diffusion-weighted imaging. Using the intravoxel incoherent motion approach, f and D were extracted and compared with postoperative tumor downstaging and volume.
RESULTS: Initial diffusion-derived parameters were within a narrow range (D1 = 0.94 ± 0.12 × 10(-3) mm(2)/s). At follow-up, D rose significantly (D2 = 1.18 ± 0.13 × 10(-3) mm(2)/s; P {\textless} 0.0001) and continued to increase significantly after CRT (D3 = 1.24 ± 0.14 × 10(-3) mm(2)/s; P {\textless} 0.0001). The perfusion fraction f did not change significantly (f1 = 9.4 ± 2.0\%, f2 = 9.4 ± 1.7\%, f3 = 9.5 ± 2.7\%). Mean volume (V) decreased significantly (V1 = 16,992 ± 13,083 mm(3); V2 = 12,793 ± 8317 mm(3), V3 = 9718 ± 6154 mm(3)). T-downstaging (10:18 patients) showed no significant correlation with diffusion-derived parameters.
CONCLUSIONS: Conflicting results in the literature considering apparent diffusion coefficient (ADC) changes in rectal carcinoma under CRT for patients showing T-downstaging are unlikely to be due to perfusion effects. Our data support the view that under effective therapy, an increase in D/ADC can be observed.},
	language = {eng},
	number = {4},
	journal = {Cancer Imaging: The Official Publication of the International Cancer Imaging Society},
	author = {Ganten, Maria-Katharina and Schuessler, Maximilian and Bäuerle, Tobias and Muenter, Marc and Schlemmer, Heinz-Peter and Jensen, Alexandra and Brand, Karsten and Dueck, Margret and Dinkel, Julien and Kopp-Schneider, Annette and Maier-Hein*, Klaus and Stieltjes, Bram},
	year = {2013},
	keywords = {Adult, Aged, Aged, 80 and over, Chemoradiotherapy, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Rectal Neoplasms, Tumor Burden},
	pages = {548--556}
}

Paper  doi  abstract   bibtex   

@article{hirai_distribution_2012,
	title = {Distribution of polybrominated diphenyl ethers in {Japanese} autopsy tissue and body fluid samples.},
	volume = {19},
	issn = {1614-7499},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22544599},
	doi = {10.1007/s11356-012-0915-z},
	abstract = {Brominated flame retardants are components of many plastics and are used in products such as cars, textiles, televisions, and personal computers. Human exposure to polybrominated diphenyl ether (PBDE) flame retardants has increased exponentially during the last three decades. Our objective was to measure the body burden and distribution of PBDEs and to determine the concentrations of the predominant PBDE congeners in samples of liver, bile, adipose tissue, and blood obtained from Japanese autopsy cases. Tissues and body fluids obtained from 20 autopsy cases were analyzed. The levels of 25 PBDE congeners, ranging from tri- to hexa-BDEs, were assessed. The geometric means of the sum of the concentrations of PBDE congeners having detection frequencies {\textbackslash}textgreater50 \% (ΣPBDE) in the blood, liver, bile, and adipose tissue were 2.4, 2.6, 1.4, and 4.3 ng/g lipid, respectively. The most abundant congeners were BDE-47 and BDE-153, followed by BDE-100, BDE-99, and BDE-28+33. These concentrations of PBDE congeners were similar to other reports of human exposure in Japan but were notably lower than concentrations than those reported in the USA. Significant positive correlations were observed between the concentrations of predominant congeners and ΣPBDE among the samples analyzed. The ΣPBDE concentration was highest in the adipose tissue, but PBDEs were distributed widely among the tissues and body fluids analyzed. The PBDE levels observed in the present study are similar to those reported in previous studies in Japan and significantly lower than those reported in the USA.},
	number = {8},
	journal = {Environmental science and pollution research international},
	author = {Hirai, Tetsuya and Fujimine, Yoshinori and Watanabe, Shaw and Nakano, Takeshi},
	month = sep,
	year = {2012},
	pmid = {22544599},
	keywords = {80 and over, Adipose Tissue, Adipose Tissue: chemistry, Adult, Aged, Asian Continental Ancestry Group, Bile, Bile: chemistry, Body Burden, Cadaver, Female, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Halogenated Diphenyl Ethers: blood, Humans, Liver, Liver: chemistry, Male, Middle Aged},
	pages = {3538--46},
}

@article{looker_lumbar_2012-1,
	title = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: {United} {States}, 2005-2008},
	issn = {0083-1980},
	shorttitle = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area},
	abstract = {OBJECTIVE: This report presents bone measurement data from dual-energy X-ray absorptiometry scans of the lumbar spine and proximal femur for persons aged 8 years and over from the National Health and Nutrition Examination Survey (NHANES) 2005-2008.
METHODS: Means, standard deviations, and selected percentiles were calculated for the proximal femur and lumbar spine (total and subregions) by sex, race and ethnicity, and age. Smoothed mean total lumbar spine and femur neck bone mineral density (BMD) were plotted by age, sex, and race and ethnicity. Multiple regression was used to test for significant interactions and to calculate mean total lumbar spine and femur neck BMD after adjusting for age, sex, and race and ethnicity. Differences by sex, race and ethnicity, and age were summarized by calculating the percent difference in adjusted means.
RESULTS: Among scanned individuals, 11\% lacked total lumbar spine data due to invalid data for one or more lumbar vertebrae, and 4\% had invalid data for the proximal femur. Non-Hispanic black persons had 6\% higher total lumbar spine BMD and 9\%-10\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD and femur neck BMD did not differ between Mexican-American and non-Hispanic white persons in those under age 20. For those aged 20 and over, Mexican-American persons had 4\% lower total lumbar spine BMD but 1\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD was 8\%-17\% higher in females aged 8-15 compared with males of the same age. In the age group 16-49, mean total lumbar spine BMD was similar or slightly higher for females compared with males, but after age 50 it was 60\%-15\% lower for females compared with males. Mean femur neck BMD was 5\%-13\% lower for females than males in all age groups except 12-15.},
	language = {eng},
	number = {251},
	journal = {Vital and Health Statistics. Series 11, Data from the National Health Survey},
	author = {Looker, Anne C. and Borrud, Lori G. and Hughes, Jeffery P. and Fan, Bo and Shepherd, John A. and Melton, L. Joseph},
	month = mar,
	year = {2012},
	pmid = {24261130},
	keywords = {Absorptiometry, Photon, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bone Density, Child, Ethnic Groups, Female, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Nutrition Surveys, Regression Analysis, Sex Factors, United States, Young Adult},
	pages = {1--132}
}

@article{spoendlin_study_2012,
	title = {A study on the epidemiology of rosacea in the {U}.{K}},
	volume = {167},
	issn = {1365-2133},
	doi = {10.1111/j.1365-2133.2012.11037.x},
	abstract = {BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09\% to 22\%. To our knowledge, incidence rates have not been quantified before.
OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5\% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80\% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8\% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95\% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.},
	language = {eng},
	number = {3},
	journal = {The British Journal of Dermatology},
	author = {Spoendlin, J. and Voegel, J. J. and Jick, S. S. and Meier, C. R.},
	month = sep,
	year = {2012},
	pmid = {22564022},
	keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alcohol Drinking, Child, Child, Preschool, Diagnosis, Differential, Epidemiologic Methods, Female, Great Britain, Humans, Infant, Life Style, Male, Middle Aged, Rosacea, Smoking, Young Adult, incidence},
	pages = {598--605}
}

@article{fuchs_icu_2012,
	title = {{ICU} admission characteristics and mortality rates among elderly and very elderly patients},
	volume = {38},
	issn = {1432-1238},
	doi = {10.1007/s00134-012-2629-6},
	abstract = {PURPOSE: The effect of advanced age per se versus severity of chronic and acute diseases on the short- and long-term survival of older patients admitted to the intensive care unit (ICU) remains unclear.
METHODS: Intensive care unit admissions to the surgical ICU and medical ICU of patients older than 65 years were analyzed. Patients were divided into three age groups: 65-74, 75-84, and 85 and above. The primary endpoints were 28-day and 1-year mortality.
RESULTS: The analysis focused on 7,265 patients above the age of 65, representing 45.7 \% of the total ICU population. From the first to third age group there was increased prevalence of heart failure (25.9-40.3 \%), cardiac arrhythmia (24.6-43.5 \%), and valvular heart disease (7.5-15.8 \%). There was reduced prevalence of diabetes complications (7.5-2.4 \%), alcohol abuse (4.1-0.6 \%), chronic obstructive pulmonary disease (COPD) (24.4-17.4 \%), and liver failure (5.0-1.0 \%). Logistic regression analysis adjusted for gender, sequential organ failure assessment, do not resuscitate, and Elixhauser score found that patients from the second and third age group had odds ratios of 1.38 [95 \% confidence interval (CI) 1.19-1.59] and 1.53 (95 \% CI 1.29-1.81) for 28-day mortality as compared with the first age group. Cox regression analysis for 1-year mortality in all populations and in 28-day survivors showed the same trend.
CONCLUSIONS: The proportion of elderly patients from the total ICU population is high. With advancing age, the proportion of various preexisting comorbidities and the primary reason for ICU admission change. Advanced age should be regarded as a significant independent risk factor for mortality, especially for ICU patients older than 75.},
	language = {eng},
	number = {10},
	journal = {Intensive Care Medicine},
	author = {Fuchs, Lior and Chronaki, Catherine E. and Park, Shinhyuk and Novack, Victor and Baumfeld, Yael and Scott, Daniel and McLennan, Stuart and Talmor, Daniel and Celi, Leo},
	month = oct,
	year = {2012},
	pmid = {22797350},
	pmcid = {PMC5718912},
	keywords = {Acute Disease, Aged, Aged, 80 and over, Chronic Disease, Comorbidity, Critical Care, Demography, Female, Hospital Mortality, Hospitalization, Humans, Intensive Care Units, Male, Outcome Assessment (Health Care), Patient Admission, Risk Factors, Survival Analysis},
	pages = {1654--1661}
}

@article{kimura_clinical_2012,
	title = {Clinical characteristics of patients with remitting seronegative symmetrical synovitis with pitting edema compared to patients with pure polymyalgia rheumatica},
	volume = {39},
	issn = {0315-162X},
	doi = {10.3899/jrheum.110558},
	abstract = {OBJECTIVE: To compare clinical features of patients with remitting seronegative symmetrical synovitis with pitting edema (RS3PE) and patients with polymyalgia rheumatica (PMR) and to explore the purported association between RS3PE and malignancy.
METHODS: We did a retrospective chart review of patients with RS3PE and PMR treated in a community-based hospital between January 2000 and December 2009. Outcomes assessed were clinical course of disease and associated malignancies.
RESULTS: We identified 28 patients with RS3PE and 123 with pure PMR. All patients with RS3PE fulfilled PMR criteria as well. Age, comorbidity, erythrocyte sedimentation rate, duration and progression of symptoms, treatment response to initial low-dose steroids, and steroid complication rates were similar in both groups. Patients with RS3PE were more likely to be male (79\% vs 41\%; p = 0.001) and to have a history of smoking (39\% vs 15\%; p = 0.008) and a higher rate of depression (11\% vs 2\%; p = 0.044) at diagnosis. Among those with RS3PE, hip pain was less common (39\% vs 74\%; p = 0.001) than in the PMR group. No patients with RS3PE and 6 patients with pure PMR (4.9\%) developed another rheumatological disease during followup. Seven of 9 patients (78\%) with concurrent cancer presented slightly more frequently with systemic symptoms compared to patients without cancer (48\%; p = 0.098), especially with fatigue (56\% vs 22\%; p = 0.037) and anorexia (33\% vs 9.0\%; p = 0.047). Despite rigorous cancer screening in patients with RS3PE, however, the rate of associated malignancy was not statistically different from that of patients with pure PMR [2 (7\%) vs 7 (6\%), respectively; p = 0.673].
CONCLUSION: Despite evidence that RS3PE is clinically distinct from PMR, we observed characteristics, treatment response, and outcomes like those expected in pure PMR. Compared to patients with pure PMR, patients with RS3PE are more likely to be male, to be depressed, and to smoke. Contrary to earlier studies, no clear association of RS3PE with malignancy was found despite rigorous cancer screening, although clinicians should be aware that patients with concurrent cancer may manifest more systemic signs and symptoms, as well as steroid resistance.},
	language = {eng},
	number = {1},
	journal = {The Journal of Rheumatology},
	author = {Kimura, Makiko and Tokuda, Yasuharu and Oshiawa, Hideto and Yoshida, Kazuki and Utsunomiya, Masako and Kobayashi, Tatsuo and Deshpande, Gautam A. and Matsui, Kazuo and Kishimoto, Mitsumasa},
	month = jan,
	year = {2012},
	pmid = {22174210},
	keywords = {Adrenal Cortex Hormones, Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Diagnosis, Differential, Disease Progression, Edema, Female, Humans, Male, Middle Aged, Neoplasms, Polymyalgia Rheumatica, Retrospective Studies, Synovitis},
	pages = {148--153}
}

@article{oconnor_combinatorial_2012,
	title = {Combinatorial pharmacogenetic interactions of bucindolol and β1, α2C adrenergic receptor polymorphisms},
	volume = {7},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0044324},
	abstract = {BACKGROUND: Pharmacogenetics involves complex interactions of gene products affecting pharmacodynamics and pharmacokinetics, but there is little information on the interaction of multiple genetic modifiers of drug response. Bucindolol is a β-blocker/sympatholytic agent whose efficacy is modulated by polymorphisms in the primary target (β(1) adrenergic receptor [AR] Arg389 Gly on cardiac myocytes) and a secondary target modifier (α(2C) AR Ins [wild-type (Wt)] 322-325 deletion [Del] on cardiac adrenergic neurons). The major allele homozygotes and minor allele carriers of each polymorphism are respectively associated with efficacy enhancement and loss, creating the possibility for genotype combination interactions that can be measured by clinical trial methodology.
METHODOLOGY: In a 1,040 patient substudy of a bucindolol vs. placebo heart failure clinical trial, we tested the hypothesis that combinations of β(1)389 and α(2C)322-325 polymorphisms are additive for both efficacy enhancement and loss. Additionally, norepinephrine (NE) affinity for β(1)389 AR variants was measured in human explanted left ventricles.
PRINCIPAL FINDINGS: The combination of β(1)389 Arg+α(2C)322-325 Wt major allele homozygotes (47\% of the trial population) was non-additive for efficacy enhancement across six clinical endpoints, with an average efficacy increase of 1.70-fold vs. 2.32-fold in β(1)389 Arg homozygotes+α(2C)322-325 Del minor allele carriers. In contrast, the minor allele carrier combination (13\% subset) exhibited additive efficacy loss. These disparate effects are likely due to the higher proportion (42\% vs. 8.7\%, P = 0.009) of high-affinity NE binding sites in β(1)389 Arg vs. Gly ARs, which converts α(2C)Del minor allele-associated NE lowering from a therapeutic liability to a benefit.
CONCLUSIONS: On combination, the two sets of AR polymorphisms 1) influenced bucindolol efficacy seemingly unpredictably but consistent with their pharmacologic interactions, and 2) identified subpopulations with enhanced (β(1)389 Arg homozygotes), intermediate (β(1)389 Gly carriers+α(2C)322-325 Wt homozygotes), and no (β(1)389 Gly carriers+α(2C)322-325 Del carriers) efficacy.},
	language = {eng},
	number = {10},
	journal = {PloS One},
	author = {O'Connor, Christopher M. and Fiuzat, Mona and Carson, Peter E. and Anand, Inder S. and Plehn, Jonathan F. and Gottlieb, Stephen S. and Silver, Marc A. and Lindenfeld, JoAnn and Miller, Alan B. and White, Michel and Walsh, Ryan and Nelson, Penny and Medway, Allen and Davis, Gordon and Robertson, Alastair D. and Port, J. David and Carr, James and Murphy, Guinevere A. and Lazzeroni, Laura C. and Abraham, William T. and Liggett, Stephen B. and Bristow, Michael R.},
	year = {2012},
	pmid = {23071495},
	pmcid = {PMC3468617},
	keywords = {Adrenergic beta-Antagonists, Adult, Aged, Female, Heart Failure, Heart Ventricles, Humans, Male, Middle Aged, Norepinephrine, Pharmacogenetics, Polymorphism, Genetic, Propanolamines, Receptors, Adrenergic, alpha-2, Receptors, Adrenergic, beta-1},
	pages = {e44324}
}

Paper  doi  bibtex   

@article{budzik_jf_diffusion_2011,
title = {Diffusion tensor imaging and fibre tracking in cervical spondylotic myelopathy},
volume = {21},
issn = {0938-7994},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20725834},
DOI = {10.1007/s00330-010-1927-z},
Language = {English},
Journal = {Eur. Radiol.},
author = {{Budzik JF} and {Balbi V} and {Le Thuc V} and {Duhamel A} and {Assaker R} and {Cotten A}},
year = {2011},
keywords = {Adult, Aged, Diffusion Tensor Imaging/methods*, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated/pathology*, Reproducibility of Results, Sensitivity and Specificity, Spinal Cord Compression/etiology*, Spinal Cord Compression/pathology*, Spondylosis/complications*, Spondylosis/pathology*},
pages = {426-433}
}

@article{kelly_london_2011,
	title = {The {London} low emission zone baseline study},
	issn = {1041-5505},
	abstract = {On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter {\textless} or = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these suggested that the clearest signals of change were most likely to be measured near roadsides. The seven key areas were also likely to be of importance in carrying out a study to assess the health outcomes of an air quality intervention like the LEZ. Of the seven key areas, two already had monitoring sites with a full complement of equipment, four had monitoring sites that required upgrades of existing equipment, and one required a completely new installation. With the upgrades and new installations in place, fully ratified (verified) pollutant data (for PM10, PM with an aerodynamic diameter {\textless} or = 2.5 microm [PM2.5], nitrogen oxides [NOx], and ozone [O3] at all sites as well as for particle number, black smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites) were then collected for analysis. In addition, the seven key monitoring sites were supported by other sites in the London Air Quality Network (LAQN). From these, a robust set of baseline air quality data was produced. Data from automatic and manual traffic counters as well as automatic license-plate recognition cameras were used to compile detailed vehicle profiles. This enabled us to establish more precise associations between ambient pollutant concentrations and vehicle emissions. An additional goal of the study was to collect baseline PM data in order to test the hypothesis that changes in traffic densities and vehicle mixes caused by the LEZ would affect the oxidative potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM data set was the first to describe, in detail, the oxidative potential and metal content of the PM10 and PM2.5 of a major city's airshed. PM in London has considerable oxidative potential; clear differences in this measure were found from site to site, with evidence that the oxidative potential of both PM10 and PM2.5 at roadside monitoring sites was higher than at urban background locations. In the PM10 samples this increased oxidative activity appeared to be associated with increased concentrations of copper (Cu), barium (Ba), and bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. In the PM2.5 samples, no simple association could be seen, suggesting that other unmeasured components were driving the increased oxidative potential in this fraction of the roadside samples. These data suggest that two components were contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10 microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived for this baseline study confirmed key observations from a more limited spatial mapping exercise published in our earlier HEI report on the introduction of the London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In addition, the data set in the current report provided robust baseline information on the oxidative potential and metal content of PM found in the London airshed in the period before implementation of the LEZ; the finding that a proportion of the oxidative potential appears in the PM coarse mode and is apparently related to brake wear raises important issues regarding the nature of traffic management schemes. The final goal of this baseline study was to establish the feasibility, in ethical and operational terms, of using the U.K.'s electronic primary-care records to evaluate the effects of the LEZ on human health outcomes. Data on consultations and prescriptions were compiled from a pilot group of general practices (13 distributed across London, with 100,000 patients; 29 situated in the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals were obtained to link individual primary-care records to modeled NOx concentrations by means of post-codes. (To preserve anonymity, the postcodes were removed before delivery to the research team.) A wide range of NOx exposures was found across London as well as within and between the practices examined. Although we observed little association between NOx exposure and smoking status, a positive relationship was found between exposure and increased socioeconomic deprivation. The health outcomes we chose to study were asthma, chronic obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory tract infections, ischemic heart disease, heart failure, and atrial fibrillation. These outcomes were measured as prevalence or incidence. Their distributions by age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord with those reported in the epidemiology literature. No cross-sectional positive associations were found between exposure to NOx and any of the studied health outcomes; some associations were significantly negative. After the pilot study, a suitable primary-care database of London patients was identified, the General Practice Research Database responsible for giving us access to these data agreed to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring privacy of the records was agreed upon. The database included about 350,000 patients who had remained at the same address over the four-year period of the study. Power calculations for a controlled longitudinal analysis were then performed, indicating that for outcomes such as consultations for respiratory illnesses or prescriptions for asthma there was sufficient power to identify a 5\% to 10\% reduction in consultations for patients most exposed to the intervention compared with patients presumed to not be exposed to it. In conclusion, the work undertaken in this study provides a good foundation for future LEZ evaluations. Our extensive monitoring network, measuring a comprehensive set of pollutants (and a range of particle metrics), will continue to provide a valuable tool both for assessing the impact of LEZ regulations on air quality in London and for furthering understanding of the link between PM's composition and toxicity. Finally, we believe that in combination with our modeling of the predicted population-based changes in pollution exposure in London, the use of primary-care databases forms a sound basis and has sufficient statistical power for the evaluation of the potential impact of the LEZ on human health.},
	language = {eng},
	number = {163},
	journal = {Research Report (Health Effects Institute)},
	author = {Kelly, Frank and Armstrong, Ben and Atkinson, Richard and Anderson, H. Ross and Barratt, Ben and Beevers, Sean and Cook, Derek and Green, Dave and Derwent, Dick and Mudway, Ian and Wilkinson, Paul and {HEI Health Review Committee}},
	month = nov,
	year = {2011},
	pmid = {22315924},
	keywords = {Adolescent, Adult, Aged, Air Pollutants, Air Pollution, Child, Child, Preschool, Cross-Sectional Studies, Environmental Exposure, Environmental Monitoring, Female, Health Status, Humans, Infant, London, Longitudinal Studies, Male, Metals, Middle Aged, Nitrogen Oxides, Particulate Matter, Pilot Projects, Primary Health Care, Small-Area Analysis, Smoking, Socioeconomic Factors, Vehicle Emissions, Young Adult},
	pages = {3--79}
}

@article{ mcelhaney_influenza_2011,
  title = {Influenza vaccine responses in older adults},
  volume = {10},
  issn = {1872-9649},
  doi = {10.1016/j.arr.2010.10.008},
  abstract = {The most profound consequences of immune senescence with respect to public health are the increased susceptibility to influenza and loss of efficacy of the current split-virus influenza vaccines in older adults, which are otherwise very effective in younger populations. Influenza infection is associated with high rates of complicated illness including pneumonia, heart attacks and strokes in the 65+ population. Changes in both innate and adaptive immune function not only converge in the reduced response to vaccination and protection against influenza, but present significant challenges to new vaccine development. In older adults, the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity. Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy. Further, antibody responses to vaccination as a correlate of protection may fail to detect important changes in cellular immunity and enhanced vaccine-mediated protection against influenza illness in older people. This article will discuss the impact of influenza in older adults, immunologic targets for improved efficacy of the vaccines, and alternative correlates of clinical protection against influenza that are needed for more effective translation of novel vaccination strategies to improved protection against influenza in older adults.},
  language = {eng},
  number = {3},
  journal = {Ageing Research Reviews},
  author = {McElhaney, Janet E.},
  month = {July},
  year = {2011},
  pmid = {21055484},
  pmcid = {PMC3061971},
  keywords = {Adaptive Immunity, Aged, Aged, 80 and over, Aging, Humans, Immunity, Innate, Influenza Vaccines, Influenza, Human, T-Lymphocytes, Treatment Outcome},
  pages = {379--388}
}

@article{hollingworth_common_2011,
	title = {Common variants at {ABCA7}, {MS4A6A}/{MS4A4E}, {EPHA1}, {CD33} and {CD2AP} are associated with {Alzheimer}'s disease},
	volume = {43},
	issn = {1546-1718},
	doi = {10.1038/ng.803},
	abstract = {We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).},
	language = {eng},
	number = {5},
	journal = {Nature Genetics},
	author = {Hollingworth, Paul and Harold, Denise and Sims, Rebecca and Gerrish, Amy and Lambert, Jean-Charles and Carrasquillo, Minerva M. and Abraham, Richard and Hamshere, Marian L. and Pahwa, Jaspreet Singh and Moskvina, Valentina and Dowzell, Kimberley and Jones, Nicola and Stretton, Alexandra and Thomas, Charlene and Richards, Alex and Ivanov, Dobril and Widdowson, Caroline and Chapman, Jade and Lovestone, Simon and Powell, John and Proitsi, Petroula and Lupton, Michelle K. and Brayne, Carol and Rubinsztein, David C. and Gill, Michael and Lawlor, Brian and Lynch, Aoibhinn and Brown, Kristelle S. and Passmore, Peter A. and Craig, David and McGuinness, Bernadette and Todd, Stephen and Holmes, Clive and Mann, David and Smith, A. David and Beaumont, Helen and Warden, Donald and Wilcock, Gordon and Love, Seth and Kehoe, Patrick G. and Hooper, Nigel M. and Vardy, Emma R. L. C. and Hardy, John and Mead, Simon and Fox, Nick C. and Rossor, Martin and Collinge, John and Maier, Wolfgang and Jessen, Frank and Rüther, Eckart and Schürmann, Britta and Heun, Reiner and Kölsch, Heike and van den Bussche, Hendrik and Heuser, Isabella and Kornhuber, Johannes and Wiltfang, Jens and Dichgans, Martin and Frölich, Lutz and Hampel, Harald and Gallacher, John and Hüll, Michael and Rujescu, Dan and Giegling, Ina and Goate, Alison M. and Kauwe, John S. K. and Cruchaga, Carlos and Nowotny, Petra and Morris, John C. and Mayo, Kevin and Sleegers, Kristel and Bettens, Karolien and Engelborghs, Sebastiaan and De Deyn, Peter P. and Van Broeckhoven, Christine and Livingston, Gill and Bass, Nicholas J. and Gurling, Hugh and McQuillin, Andrew and Gwilliam, Rhian and Deloukas, Panagiotis and Al-Chalabi, Ammar and Shaw, Christopher E. and Tsolaki, Magda and Singleton, Andrew B. and Guerreiro, Rita and Mühleisen, Thomas W. and Nöthen, Markus M. and Moebus, Susanne and Jöckel, Karl-Heinz and Klopp, Norman and Wichmann, H.-Erich and Pankratz, V. Shane and Sando, Sigrid B. and Aasly, Jan O. and Barcikowska, Maria and Wszolek, Zbigniew K. and Dickson, Dennis W. and Graff-Radford, Neill R. and Petersen, Ronald C. and {Alzheimer's Disease Neuroimaging Initiative} and van Duijn, Cornelia M. and Breteler, Monique M. B. and Ikram, M. Arfan and DeStefano, Anita L. and Fitzpatrick, Annette L. and Lopez, Oscar and Launer, Lenore J. and Seshadri, Sudha and {CHARGE consortium} and Berr, Claudine and Campion, Dominique and Epelbaum, Jacques and Dartigues, Jean-François and Tzourio, Christophe and Alpérovitch, Annick and Lathrop, Mark and {EADI1 consortium} and Feulner, Thomas M. and Friedrich, Patricia and Riehle, Caterina and Krawczak, Michael and Schreiber, Stefan and Mayhaus, Manuel and Nicolhaus, S. and Wagenpfeil, Stefan and Steinberg, Stacy and Stefansson, Hreinn and Stefansson, Kari and Snaedal, Jon and Björnsson, Sigurbjörn and Jonsson, Palmi V. and Chouraki, Vincent and Genier-Boley, Benjamin and Hiltunen, Mikko and Soininen, Hilkka and Combarros, Onofre and Zelenika, Diana and Delepine, Marc and Bullido, Maria J. and Pasquier, Florence and Mateo, Ignacio and Frank-Garcia, Ana and Porcellini, Elisa and Hanon, Olivier and Coto, Eliecer and Alvarez, Victoria and Bosco, Paolo and Siciliano, Gabriele and Mancuso, Michelangelo and Panza, Francesco and Solfrizzi, Vincenzo and Nacmias, Benedetta and Sorbi, Sandro and Bossù, Paola and Piccardi, Paola and Arosio, Beatrice and Annoni, Giorgio and Seripa, Davide and Pilotto, Alberto and Scarpini, Elio and Galimberti, Daniela and Brice, Alexis and Hannequin, Didier and Licastro, Federico and Jones, Lesley and Holmans, Peter A. and Jonsson, Thorlakur and Riemenschneider, Matthias and Morgan, Kevin and Younkin, Steven G. and Owen, Michael J. and O'Donovan, Michael and Amouyel, Philippe and Williams, Julie},
	month = may,
	year = {2011},
	pmid = {21460840},
	pmcid = {PMC3084173},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Aged, 80 and over, Genetic Predisposition to Disease, Case-Control Studies, Genome-Wide Association Study, Adaptor Proteins, Signal Transducing, Polymorphism, Single Nucleotide, Antigens, CD, Antigens, Differentiation, Myelomonocytic, ATP-Binding Cassette Transporters, Cytoskeletal Proteins, Databases, Genetic, Genetic Variation, Membrane Proteins, Multigene Family, Receptor, EphA1, Sialic Acid Binding Ig-like Lectin 3},
	pages = {429--435}
}

@article{humes_concurrent_2011,
	title = {Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study},
	volume = {60},
	issn = {1468-3288},
	shorttitle = {Concurrent drug use and the risk of perforated colonic diverticular disease},
	doi = {10.1136/gut.2010.217281},
	abstract = {OBJECTIVE: To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists.
DESIGN, SETTING AND PARTICIPANTS: Case-control analysis using conditional logistic regression analysis of data from the UK General Practice Research Database. The study involved 899 cases of incident diverticular perforation and 8980 population controls from 1990 to 2005.
MAIN OUTCOME MEASURES: Odds ratios (ORs) are presented for perforation associated with use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists. Data were adjusted for smoking, comorbidity, prior abdominal pain and body mass index.
RESULTS: A total of 899 patients with an incident diagnosis of perforated diverticular disease were identified. Current use of opiate analgesics (OR=2.16; 95\% CI 1.55 to 3.01) and oral corticosteroids (OR=2.74; 95\% CI 1.63 to 4.61) was associated with a two- and threefold increase in the risk of diverticular perforation, respectively. Current use of a calcium antagonist and aspirin were not associated with an increased risk of diverticular perforation. Current statin use was associated with a reduction in the risk of perforation (OR=0.44; 95\% CI 0.20 to 0.95).
CONCLUSION: Perforated diverticular disease is a serious surgical emergency with current opiate analgesics and oral corticosteroids being strongly associated with an increased risk of diverticular perforation.},
	language = {eng},
	number = {2},
	journal = {Gut},
	author = {Humes, David J. and Fleming, Kate M. and Spiller, Robin C. and West, Joe},
	month = feb,
	year = {2011},
	pmid = {20940283},
	keywords = {Aged, Aged, 80 and over, Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Cardiovascular Agents, Comorbidity, Confounding Factors (Epidemiology), Diverticulum, Colon, Drug-Related Side Effects and Adverse Reactions, Epidemiologic Methods, Female, Glucocorticoids, Great Britain, Humans, Intestinal Perforation, Male, Middle Aged},
	pages = {219--224}
}

Paper  doi  abstract   bibtex   

@article{gow_stability_2011,
	title = {Stability and change in intelligence from age 11 to ages 70, 79, and 87: the {Lothian} {Birth} {Cohorts} of 1921 and 1936.},
	volume = {26},
	issn = {1939-1498},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/20973608},
	doi = {10.1037/a0021072},
	abstract = {Investigating the predictors of age-related cognitive change is a research priority. However, it is first necessary to discover the long-term stability of measures of cognitive ability because prior cognitive ability level might contribute to the amount of cognitive change experienced within old age. These two issues were examined in the Lothian Birth Cohorts of 1921 and 1936. Cognitive ability data were available from age 11 years when the participants completed the Moray House Test No. 12 (MHT). The Lothian Birth Cohort 1936 (LBC1936) completed the MHT a second time at age 70. The Lothian Birth Cohort 1921 (LBC1921) completed the MHT at ages 79 and 87. We examined cognitive stability and change from childhood to old age in both cohorts, and within old age in the LBC1921. Raw stability coefficients for the MHT from 11-70, 11-79, and 11-87 years were .67, .66, and .51, respectively; and larger when corrected for range restriction in the samples. Therefore, minimum estimates of the variance in later-life MHT accounted for by childhood performance on the same test ranged from 26-44\%. This study also examined, in the LBC1921, whether MHT score at age 11 influenced the amount of change in MHT between ages 79 and 87. It did not. Higher intelligence from early life was apparently protective of intelligence in old age due to the stability of cognitive function across the lifespan, rather than because it slowed the decline experienced in later life.},
	number = {1},
	urldate = {2012-07-23},
	journal = {Psychology and aging},
	author = {Gow, Alan J and Johnson, Wendy and Pattie, Alison and Brett, Caroline E and Roberts, Beverly and Starr, John M and Deary, Ian J},
	month = mar,
	year = {2011},
	pmid = {20973608},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Aging, Aging: physiology, Aging: psychology, Child, Cognition, Cognition: physiology, Female, Humans, Intelligence, Intelligence Tests, Intelligence: physiology, Longitudinal Studies, Male, Middle Aged, Scotland, Young Adult},
	pages = {232--40},
}

@article{filion_thiazolidinediones_2011,
	title = {Thiazolidinediones and the risk of incident congestive heart failure among patients with type 2 diabetes mellitus},
	volume = {20},
	issn = {1099-1557},
	doi = {10.1002/pds.2165},
	abstract = {BACKGROUND: Clinical trials suggest that thiazolidinediones (TZDs) may increase the risk of congestive heart failure (CHF). However, their effect on the risk of incident CHF in unselected populations has not been thoroughly investigated.
METHODS: Using data from the UK's General Practice Research Database, we conducted a case-control study within a population-based cohort of patients with type 2 diabetes. Cases were identified by a clinical diagnosis of incident CHF and were then classified as possible or probable cases using prescription data. A 90-day drug exposure window was used in the primary analysis, which compared patients prescribed TZDs with those with no prescriptions for anti-diabetic medications.
RESULTS: We identified 3405 incident cases (2632 probable and 773 possible) of CHF and 32,042 corresponding controls. TZDs were prescribed in 6.4\% of cases and 6.3\% of controls. Prescription of TZDs was associated with an increased rate of possible or probable CHF (adjusted rate ratio (RR) = 1.24, 95\% CI = 1.01, 1.54 and adjusted RR = 1.24, 95\% CI = 0.98, 1.58, respectively). Similar results were obtained when using a 180-day exposure window (RR = 1.38, 95\% CI = 1.11, 1.72 and RR = 1.44, 95\% CI = 1.12, 1.84, respectively).
CONCLUSIONS: Given the totality of the evidence from this and previous studies, the probability of an increased risk for CHF with these agents remains high. However, any increase in CHF risk associated with TZDs may be lower than previously reported.},
	language = {eng},
	number = {8},
	journal = {Pharmacoepidemiology and Drug Safety},
	author = {Filion, Kristian B. and Joseph, Lawrence and Boivin, Jean-François and Suissa, Samy and Brophy, James M.},
	month = aug,
	year = {2011},
	pmid = {21671441},
	keywords = {Aged, Aged, 80 and over, Case-Control Studies, Databases, Factual, Diabetes Mellitus, Type 2, Female, Great Britain, Heart Failure, Humans, Hypoglycemic Agents, Male, Middle Aged, Risk, Thiazolidinediones},
	pages = {785--796}
}

@article{persell_changes_2011,
	title = {Changes in performance after implementation of a multifaceted electronic-health-record-based quality improvement system},
	volume = {49},
	issn = {1537-1948},
	doi = {10.1097/MLR.0b013e318202913d},
	abstract = {BACKGROUND: Electronic health record (EHR) systems have the potential to revolutionize quality improvement (QI) methods by enhancing quality measurement and integrating multiple proven QI strategies.
OBJECTIVES: To implement and evaluate a multifaceted QI intervention using EHR tools to improve quality measurement (including capture of contraindications and patient refusals), make point-of-care reminders more accurate, and provide more valid and responsive clinician feedback (including lists of patients not receiving essential medications) for 16 chronic disease and preventive service measures.
DESIGN: Time series analysis at a large internal medicine practice using a commercial EHR.
SUBJECTS: All adult patients eligible for each measure (range approximately 100-7500).
MEASURES: The proportion of eligible patients who satisfied each measure after removing those with exceptions from the denominator.
RESULTS: During the year before the intervention, performance improved significantly for 8 measures. During the year after the intervention, performance improved significantly for 14 measures. For 9 measures, the primary outcome improved more rapidly during the intervention year than during the previous year (P {\textless} 0.001 for 8 measures, P = 0.02 for 1). Four other measures improved at rates that were not significantly different from the previous year. Improvements resulted from increases in patients receiving the service, documentation of exceptions, or a combination of both. For 5 drug-prescribing measures, more than half of physicians achieved 100\% performance.
CONCLUSIONS: Implementation of a multifaceted QI intervention using EHR tools to improve quality measurement and the accuracy and timeliness of clinician feedback improved performance and/or accelerated the rate of improvement for multiple measures simultaneously.},
	language = {eng},
	number = {2},
	journal = {Medical Care},
	author = {Persell, Stephen D. and Kaiser, Darren and Dolan, Nancy C. and Andrews, Beth and Levi, Sue and Khandekar, Janardan and Gavagan, Thomas and Thompson, Jason A. and Friesema, Elisha M. and Baker, David W.},
	month = feb,
	year = {2011},
	pmid = {21178789},
	keywords = {Aged, Chicago, Coronary Disease, Decision Support Systems, Clinical, Diabetes Mellitus, Documentation, Drug Prescriptions, Electronic Health Records, Female, Heart Failure, Humans, Internal Medicine, Linear Models, Longitudinal Studies, Male, Middle Aged, Outcome Assessment (Health Care), Physician's Practice Patterns, Point-of-Care Systems, Program Evaluation, Quality Indicators, Health Care, Reminder Systems, Total Quality Management},
	pages = {117--125}
}

Paper  abstract   bibtex   

@article{win_influenza_2010,
	title = {Influenza {B} {Outbreak} among influenza-vaccinated welfare home residents in {Singapore}},
	volume = {39},
	issn = {0304-4602},
	url = {http://www.annals.edu.sg/pdf/39VolNo6Jun2010/V39N6p448.pdf http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed11&NEWS=N&AN=359159306},
	abstract = {Introduction: Outbreaks of acute respiratory illness occur commonly in long-term care facilities (LTCF), due to the close proximity of residents. Most influenza outbreak reports have been from temperate countries. This study reports an outbreak of infl uenza B among a highly immunised resident population in a welfare home in tropical Singapore, and discusses vaccine effi cacy and the role of acute respiratory illness surveillance for outbreak prevention and control. Material(s) and Method(s): During the period from 16 to 21 March 2007, outbreak investigations and active case fi nding were carried out among residents and nursing staff at the welfare home. Interviews and medical notes review were conducted to obtain epidemiological and clinical data. Hospitalised patients were tested for respiratory pathogens. Further genetic studies were also carried out on positive respiratory samples. Result(s): The overall clinical attack rate was 9.4\% (17/180) in residents and 6.7\% (2/30) in staff. All infected residents and staff had received infl uenza immunisation. Fifteen residents were hospitalised, with 2 developing severe complications. Genetic sequencing revealed that the outbreak strain had an 8.2\% amino acid difference from B/Malaysia/2506/2004, the 2006 southern hemisphere infl uenza vaccine strain, which the residents and staff had earlier received. Conclusion(s): A mismatch between the vaccine and circulating infl uenza virus strains can result in an outbreak in a highly immunised LTCF resident population. Active surveillance for acute respiratory illness in LTCFs could be implemented for rapid detection of antigenic drift. Enhanced infection control and other preventive measures can then be deployed in a timely manner to mitigate the effect of any outbreaks.},
	language = {English},
	number = {6},
	journal = {Annals of the Academy of Medicine Singapore},
	author = {Win, M. K. and Chow, A. and Chen, M. and Lau, Y. F. and Ooi, E. E. and Leo, Y. S.},
	year = {2010},
	keywords = {*influenza B/dt [Drug Therapy], *influenza B/pc [Prevention], *influenza vaccination, *influenza vaccine/dt [Drug Therapy], Singapore, adult, aged, article, case finding, clinical article, clinical feature, controlled study, disease severity, disease surveillance, drug efficacy, epidemic, gene sequence, hospitalization, human, infection control, influenza B/dt [Drug Therapy], polymerase chain reaction, residential home, strain difference, thorax radiography, virus strain},
	pages = {448--452},
}

@article{laumet_study_2010,
	title = {A study of the association between the {ADAM12} and {SH3PXD2A} ({SH3MD1}) genes and {Alzheimer}'s disease},
	volume = {468},
	issn = {1872-7972},
	doi = {10.1016/j.neulet.2009.10.040},
	abstract = {Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to beta-amyloid (Abeta) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Abeta. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for ADAM12). A recent study reported a statistically significant interaction between 2 variants of these genes (rs3740473 for SH3PXD2A and rs11244787 for ADAM12) with respect to the risk of developing AD. With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results.},
	language = {eng},
	number = {1},
	journal = {Neuroscience Letters},
	author = {Laumet, Geoffroy and Petitprez, Vincent and Sillaire, Adeline and Ayral, Anne-Marie and Hansmannel, Franck and Chapuis, Julien and Hannequin, Didier and Pasquier, Florence and Scarpini, Elio and Galimberti, Daniela and Lendon, Corinne and Campion, Dominique and Amouyel, Philippe and Lambert, Jean-Charles},
	month = jan,
	year = {2010},
	pmid = {19837132},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Genetic Predisposition to Disease, Risk Factors, Case-Control Studies, Polymorphism, Single Nucleotide, European Continental Ancestry Group, Membrane Proteins, ADAM Proteins, ADAM12 Protein, Adaptor Proteins, Vesicular Transport},
	pages = {1--2}
}

@article{hippisley-cox_individualising_2010,
	title = {Individualising the risks of statins in men and women in {England} and {Wales}: population-based cohort study},
	volume = {96},
	issn = {1468-201X},
	shorttitle = {Individualising the risks of statins in men and women in {England} and {Wales}},
	doi = {10.1136/hrt.2010.199034},
	abstract = {OBJECTIVE: To derive and validate risk algorithms so that the risks of four clinical outcomes associated with statin use can be estimated for individual patients.
DESIGN: Prospective open cohort study using routinely collected data from 368 QResearch general practices in England and Wales to develop the scores. The scores were validated using two separate sets of practices-188 separate QResearch practices and 364 practices contributing to the THIN database.
SUBJECTS: In the QResearch derivation cohort 225 922 new users of statins and 1 778 770 non-users of statins were studied. In the QResearch validation cohort 118 372 statin users and 877 812 non-users of statins were studied. In the THIN validation cohort, we studied 282 056 statin users and 1 923 840 non-users of statins were studied.
METHODS: Cox proportional hazards models in the derivation cohort to derive risk equations. Measures of calibration and discrimination in both validation cohorts.
OUTCOMES: 5-Year risk of moderate/serious myopathic events; moderate/serious liver dysfunction; acute renal failure and cataract.
RESULTS: The performance of three of the risk prediction algorithms in the THIN cohort was very good. For example, in women, the algorithm for moderate/serious myopathy explained 42.15\% of the variation. The corresponding D statistics was 1.75. The acute renal failure algorithm explained 59.62\% of the variation (D statistic=2.49). The cataract algorithm explained 59.14\% of the variation (D statistic=2.46). The algorithms to predict moderate/severe liver dysfunction only explained 15.55\% of the variation (D statistics=0.89). The performance of each algorithm was similar for both sexes when tested on the QResearch validation cohort.
CONCLUSIONS: The algorithms to predict acute renal failure, moderate/serious myopathy and cataract could be used to identify patients at increased risk of these adverse effects enabling patients to be monitored more closely. Further research is needed to develop a better algorithm to predict liver dysfunction.},
	language = {eng},
	number = {12},
	journal = {Heart (British Cardiac Society)},
	author = {Hippisley-Cox, Julia and Coupland, Carol},
	month = jun,
	year = {2010},
	pmid = {20489220},
	keywords = {Acute Kidney Injury, Adult, Aged, Aged, 80 and over, Algorithms, Body Mass Index, Cataract, Drug-Induced Liver Injury, England, Epidemiologic Methods, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Muscular Diseases, Wales},
	pages = {939--947}
}

Paper  doi  bibtex   

@article{tacelli_n_assessment_2010,
title = {Assessment of Non-Small Cell Lung Cancer Perfusion: Pathologic-CT Correlation in 15 Patients},
volume = {257},
issn = {0033-8419},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20843993},
DOI = {10.1148/radiol.10100181},
Language = {English},
Journal = {Radiology},
author = {{Tacelli N} and {Remy-Jardin M} and {Copin MC} and {Scherpereel A} and {Mensier E} and {Jaillard S} and {Lafitte JJ} and {Klotz E} and {Duhamel A} and {Remy J}},
year = {2010},
keywords = {Aged, Carcinoma, Non-Small-Cell Lung/blood supply, Carcinoma, Non-Small-Cell Lung/diagnostic imaging*, Carcinoma, Non-Small-Cell Lung/pathology, Chi-Square Distribution, Contrast Media, Female, Humans, Iohexol/analogs & derivatives, Lung Neoplasms/blood supply, Lung Neoplasms/diagnostic imaging*, Lung Neoplasms/pathology, Male, Middle Aged, Prospective Studies, Statistics, Nonparametric, Tomography, X-Ray Computed/methods*},
pages = {863-871}
}

@article{hansmannel_is_2010,
	title = {Is the urea cycle involved in {Alzheimer}'s disease?},
	volume = {21},
	issn = {1875-8908},
	doi = {10.3233/JAD-2010-100630},
	abstract = {Since previous observations indicated that the urea cycle may have a role in the Alzheimer's disease (AD) process, we set out to quantify the expression of each gene involved in the urea cycle in control and AD brains and establish whether these genes could be genetic determinants of AD. We first confirmed that all the urea cycle enzyme genes are expressed in the AD brain. The expression of arginase 2 was greater in the AD brain than in the control brain. The presence of the rare arginase 2 allele rs742869 was associated with an increase in the risk of AD in men and with an earlier age-at-onset for both genders. None of the other genes in the pathway appeared to be differentially expressed in the AD brain or act as genetic determinants of the disease.},
	language = {eng},
	number = {3},
	journal = {Journal of Alzheimer's disease: JAD},
	author = {Hansmannel, Franck and Sillaire, Adeline and Kamboh, M. Ilyas and Lendon, Corinne and Pasquier, Florence and Hannequin, Didier and Laumet, Geoffroy and Mounier, Anais and Ayral, Anne-Marie and DeKosky, Steven T. and Hauw, Jean-Jacques and Berr, Claudine and Mann, David and Amouyel, Philippe and Campion, Dominique and Lambert, Jean-Charles},
	year = {2010},
	pmid = {20693631},
	pmcid = {PMC2945690},
	keywords = {Aged, Alzheimer Disease, Humans, Female, Male, Middle Aged, Brain, Aged, 80 and over, Chi-Square Distribution, Risk Factors, Alleles, Genotype, Case-Control Studies, Genetic Association Studies, Arginase, Urea},
	pages = {1013--1021}
}

@article{fan_does_2010,
	title = {Does standardized {BMD} still remove differences between {Hologic} and {GE}-{Lunar} state-of-the-art {DXA} systems?},
	volume = {21},
	issn = {1433-2965},
	doi = {10.1007/s00198-009-1062-3},
	abstract = {The standardized bone mineral density (sBMD) values, derived using universal standardized equations, were shown to be equivalent within 1.0\% for hip but significantly different for spine for state-of-art fan-beam dual X-ray absorptiometry (DXA) Hologic and GE-Lunar systems. Spine L1-L4 and L2-L4 sBMD mean differences between the two systems were 0.042 g/cm(2) (4.1\%) and 0.035 g/cm(2) (3.2\%), respectively.
INTRODUCTION: The objective of this study is to validate the 1994 pencil-beam DXA "universal standardization equations" for state-of-the-art fan-beam DXA systems.
METHODS: The spine and bilateral femurs of 87 postmenopausal women were scanned on both Hologic Delphi and GE-Lunar Prodigy DXA systems at three different clinical centers. The scans were analyzed using Hologic Apex and GE-Lunar EnCore software. The BMD results were converted to sBMD using the equations previously developed. Linear regression analysis was used to describe the relationship of the two systems' BMD results. Bland-Altman analysis was used to assess the differences in measures.
RESULTS: The Apex and Prodigy sBMD values were highly correlated (r ranged from 0.92 to 0.98). Spine L1-L4 and L2-L4 sBMD values had significant intercepts and slopes for Bland-Altman regression, with mean differences of 0.042 g/cm(2) (4.1\%) and 0.035 g/cm(2) (3.2\%), respectively. The total hip and neck sBMD showed no significant intercept and slope, except left total sBMD had a significant difference between the two systems of 0.009 g/cm(2) (1.0\%).
CONCLUSIONS: The sBMD values were shown to be equivalent within 1.0\% for hip but were significantly different for spine on the two systems. Biases may persist in pooled sBMD data from different manufacturers, and further study is necessary to determine the cause.},
	language = {eng},
	number = {7},
	journal = {Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA},
	author = {Fan, B. and Lu, Y. and Genant, H. and Fuerst, T. and Shepherd, J.},
	month = jul,
	year = {2010},
	pmid = {19859644},
	pmcid = {PMC2906746},
	keywords = {Absorptiometry, Photon, Aged, Aged, 80 and over, Bone Density, Female, Femur Neck, Hip Joint, Humans, Lumbar Vertebrae, Middle Aged, Reproducibility of Results},
	pages = {1227--1236}
}

@article{mehta_patients_2010,
	title = {Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the {General} {Practice} {Research} {Database}},
	volume = {31},
	issn = {1522-9645},
	shorttitle = {Patients with severe psoriasis are at increased risk of cardiovascular mortality},
	doi = {10.1093/eurheartj/ehp567},
	abstract = {AIMS: Psoriasis is a common chronic inflammatory T-helper cell-1/17 mediated skin disease. Recent studies suggest that psoriasis, particularly if severe, may be an independent risk factor for atherosclerosis, myocardial infarction (MI), and stroke. We conducted a cohort study using the General Practice Research Database to determine if severe psoriasis patients have an increased risk of cardiovascular (CV) mortality.
METHODS AND RESULTS: Severe psoriasis was defined as patients who received a psoriasis diagnosis and systemic therapy consistent with severe psoriasis (n = 3603). Up to four unexposed patients without psoriasis were selected from the same practices and start dates for each psoriasis patient (n = 14 330). For every death, the cause was determined by review of the electronic medical record. Severe psoriasis was an independent risk factor for CV mortality (HR 1.57; 95\% CI 1.26, 1.96) when adjusting for age, sex, smoking, diabetes, hypertension, and hyperlipidaemia. Overall, severe psoriasis patients experienced one extra CV death per 283 patients per year, even when adjusting for major CV risk factors. The relative risk of CV mortality was modified by age. For example, the RR of CV death for a 40-year-old and 60-year-old with severe psoriasis was 2.69 (1.45, 4.99) and 1.92 (1.41, 2.62), respectively. The findings were robust to multiple sensitivity analyses.
CONCLUSION: Patients with severe psoriasis have an increased risk of CV mortality that is independent of traditional CV risk factors. Additional studies are needed to determine the mechanism of this association and the impact that control of psoriasis has on CV risk.},
	language = {eng},
	number = {8},
	journal = {European Heart Journal},
	author = {Mehta, Nehal N. and Azfar, Rahat S. and Shin, Daniel B. and Neimann, Andrea L. and Troxel, Andrea B. and Gelfand, Joel M.},
	month = apr,
	year = {2010},
	pmid = {20037179},
	pmcid = {PMC2894736},
	keywords = {Adult, Aged, Cardiovascular Diseases, Dermatologic Agents, Female, Great Britain, Humans, Male, Middle Aged, Psoriasis, Risk Factors, incidence},
	pages = {1000--1006}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease.},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Aged,Blood Pressure,Blood Pressure: drug effects,Blood Pressure: physiology,Coronary Artery Disease,Environmental Exposure,Environmental Exposure: adverse effects,Environmental Exposure: analysis,Female,Humans,Los Angeles,Male,Monitoring, Ambulatory,Vehicle Emissions,Vehicle Emissions: analysis,Vehicle Emissions: toxicity},
 pages = {396-404},
 volume = {21},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/20335815},
 month = {5},
 institution = {Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617, USA. rdelfino@uci.edu},
 id = {01e147e5-41ed-3ae1-b25a-37200eaf1f36},
 created = {2014-06-01T21:16:03.000Z},
 accessed = {2013-05-26},
 file_attached = {true},
 profile_id = {9edae5ec-3a23-3830-8934-2c27bef6ccbe},
 group_id = {63e349d6-2c70-3938-9e67-2f6483f6cbab},
 last_modified = {2014-11-19T06:03:46.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 abstract = {BACKGROUND: Associations between blood pressure (BP) and ambient air pollution have been inconsistent. No studies have used ambulatory BP monitoring and outdoor home air-pollutant measurements with time-activity-location data. We address these gaps in a study of 64 elderly subjects with coronary artery disease, living in retirement communities in the Los Angeles basin. METHODS: Subjects were followed up for 10 days with hourly waking ambulatory BP monitoring (n = 6539 total measurements), hourly electronic diaries for perceived exertion and location, and real-time activity monitors (actigraphs). We measured hourly outdoor home pollutant gases, particle number, PM2.5, organic carbon, and black carbon. Data were analyzed with mixed models controlling for temperature, posture, actigraph activity, hour, community, and season. RESULTS: We found positive associations of systolic and diastolic BP with air pollutants. The strongest associations were with organic carbon (especially its estimated fossil-fuel- combustion fraction), multiday average exposures, and time periods when subjects were at home. An interquartile increase in 5-day average organic carbon (5.2 microg/m) was associated with 8.2 mm Hg higher mean systolic BP (95% confidence interval = 3.0-13.4) and 5.8 mm Hg higher mean diastolic BP (3.0-8.6). Associations of BP with 1-8 hour average air pollution were stronger with reports of moderate to strenuous physical exertion but not with higher actigraph motion. Associations were also stronger among 12 obese subjects. CONCLUSIONS: Exposure to primary organic components of fossil fuel combustion near the home were strongly associated with increased ambulatory BP in a population at potential risk of heart attack. Low fitness or obesity may increase the effects of pollutants.},
 bibtype = {article},
 author = {Delfino, Ralph J and Tjoa, Thomas and Gillen, Daniel L and Staimer, Norbert and Polidori, Andrea and Arhami, Mohammad and Jamner, Larry and Sioutas, Constantinos and Longhurst, John},
 journal = {Epidemiology Cambridge Mass},
 number = {3}
}

@article{allin_baseline_2009,
	title = {Baseline {C}-reactive protein is associated with incident cancer and survival in patients with cancer},
	volume = {27},
	issn = {1527-7755},
	doi = {10.1200/JCO.2008.19.8440},
	abstract = {PURPOSE: We tested the hypothesis that baseline plasma levels of C-reactive protein (CRP) are associated with risk of incident cancer in the general population and early death in patients with cancer.
PATIENTS AND METHODS: A total of 10,408 individuals from the Danish general population who had CRP measured at baseline were observed for up to 16 years; 1,624 developed cancer, and of these, 998 patients died during follow-up. Follow-up was 100\% complete. We excluded individuals with a cancer diagnosis at baseline.
RESULTS: Baseline CRP levels more than 3 versus less than 1 mg/L were associated with multifactorially adjusted hazard ratios of 1.3 (95\% CI, 1.0 to 1.6) for cancer of any type, 2.2 (95\% CI, 1.0 to 4.6) for lung cancer, 1.9 (95\% CI, 0.8 to 4.6) for colorectal cancer, and 0.7 (95\% CI, 0.4 to 1.4) for breast cancer. Corresponding hazard ratios for the highest versus the lowest quintile of baseline CRP levels were 1.3 (95\% CI, 1.0 to 1.6), 2.1 (95\% CI, 1.2 to 3.8), 1.7 (95\% CI, 0.8 to 3.2), and 0.9 (95\% CI, 0.5 to 1.7), respectively. Multifactorially adjusted hazard ratios for early death in patients with cancer were 1.8 (95\% CI, 1.2 to 2.7) for CRP more than 3 versus less than 1 mg/L and 1.4 (95\% CI, 1.1 to 1.7) for the highest versus the lowest quintile. Elevated CRP levels were associated with early death in patients with cancer having localized disease, but not in those with metastases (interaction; P = .03).
CONCLUSION: Elevated levels of CRP in cancer-free individuals are associated with increased risk of cancer of any type, of lung cancer, and possibly of colorectal cancer. Moreover, elevated levels of baseline CRP associate with early death after a diagnosis of any cancer, particularly in patients without metastases.},
	language = {eng},
	number = {13},
	journal = {Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology},
	author = {Allin, Kristine H. and Bojesen, Stig E. and Nordestgaard, Børge G.},
	month = may,
	year = {2009},
	pmid = {19289618},
	keywords = {Adult, Aged, C-Reactive Protein, Cohort Studies, Female, Humans, Male, Middle Aged, Neoplasms, Prospective Studies},
	pages = {2217--2224},
}

Paper  doi  bibtex   

@article{agosta_apolipoprotein_2009,
	title = {Apolipoprotein {E} epsilon4 is associated with disease-specific effects on brain atrophy in {Alzheimer}'s disease and frontotemporal dementia},
	volume = {106},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19164761},
	doi = {10.1073/pnas.0812697106},
	number = {6},
	journal = {Proc Natl Acad Sci U S A},
	author = {Agosta, F. and Vossel, K.A. and Miller, B.L. and Migliaccio, R. and Bonasera, S.J. and Filippi, M. and Boxer, A.L. and Karydas, A. and Possin, K.L. and Gorno-Tempini, M.L.},
	year = {2009},
	keywords = {\#nosource, Adult, Aged, Aged, 80 and over, Alzheimer Disease/*pathology, Apolipoprotein E4/*genetics, Atrophy, Brain Mapping, Brain/*pathology, Case-Control Studies, Dementia/*pathology, Gene Frequency, Hippocampus/pathology, Humans, Middle Aged, Parietal Lobe/pathology, Prognosis, Temporal Lobe/*pathology},
	pages = {2018--22},
}

@article{lutgers_skin_2009,
	title = {Skin autofluorescence provides additional information to the {UK} {Prospective} {Diabetes} {Study} ({UKPDS}) risk score for the estimation of cardiovascular prognosis in type 2 diabetes mellitus},
	volume = {52},
	issn = {1432-0428},
	doi = {10.1007/s00125-009-1308-9},
	abstract = {AIMS/HYPOTHESIS: The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin autofluorescence for cardiovascular events in combination with the UKPDS risk engine in a cohort of patients with type 2 diabetes managed in primary care.
METHODS: Clinical, UKPDS risk engine and skin autofluorescence data were obtained at baseline in 2001-2002 in the type 2 diabetes group (n = 973). Follow-up data concerning fatal and non-fatal cardiovascular events (primary endpoint) were obtained till 2005. Patients were classified as 'low risk' when their 10 year UKPDS risk score for fatal cardiovascular events was {\textless}10\%, and 'high risk' if {\textgreater}10\%. Skin autofluorescence was measured non-invasively with an autofluorescence reader. Skin autofluorescence was classified by the median (i.e. low risk {\textless} median, high risk {\textgreater} median).
RESULTS: The incidence of cardiovascular events was 119 (44 fatal, 75 non-fatal). In multivariate analysis, skin autofluorescence, age, sex and diabetes duration were predictors for the primary endpoint. Addition of skin autofluorescence information to that from the UKPDS risk engine resulted in re-classification of 55 of 203 patients from the low-risk to the high-risk group. The 10 year cardiovascular event rate was higher in patients with a UKPDS score {\textgreater}10\% when skin autofluorescence was above the median (55.8\% vs 38.9\%).
CONCLUSIONS/INTERPRETATION: Skin autofluorescence provides additional information to the UKPDS risk engine which can result in risk re-classification of a substantial number of patients. It furthermore identifies patients who have a particularly high risk for developing cardiovascular events.},
	language = {eng},
	number = {5},
	journal = {Diabetologia},
	author = {Lutgers, H. L. and Gerrits, E. G. and Graaff, R. and Links, T. P. and Sluiter, W. J. and Gans, R. O. and Bilo, H. J. and Smit, A. J.},
	month = may,
	year = {2009},
	pmid = {19274450},
	keywords = {AGE Reader in diabetes, Aged, Analysis of Variance, Arm, Blood Pressure, Cardiovascular Diseases, Cohort Studies, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Fluorescence, Glycated Hemoglobin A, Glycation End Products, Advanced, Humans, Key Publications, Light, Male, Middle Aged, Multivariate Analysis, Physicians, Family, Prognosis, Risk Assessment, Skin, United Kingdom},
	pages = {789--797},
}

Paper  doi  abstract   bibtex   

@article{filipits_low_2009,
	title = {Low p27 expression predicts early relapse and death in postmenopausal hormone receptor-positive breast cancer patients receiving adjuvant tamoxifen therapy},
	volume = {15},
	issn = {1078-0432},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19723645},
	doi = {10.1158/1078-0432.CCR-09-0728},
	abstract = {PURPOSE: Previously, we have shown that p27 may be a potential predictive biomarker for the selection of premenopausal women with early-stage hormone-responsive breast cancer for adjuvant endocrine therapy. The purpose of the present study was to assess the clinical relevance of p27 expression in postmenopausal hormone receptor-positive breast cancer patients who were treated with adjuvant tamoxifen therapy. EXPERIMENTAL DESIGN: We determined the expression of p27 by immunohistochemistry in the surgical specimens of breast carcinoma patients who had been enrolled in Austrian Breast and Colorectal Cancer Study Group Trial 06 and received tamoxifen for 5 years. Early relapse and death within the first 5 years of follow-up were analyzed using Cox models adjusted for clinical and pathologic factors. RESULTS: p27 expression was high ({\textgreater}70\% p27-positive tumor cells) in 252 of 483 (52\%) tumor specimens and was associated with favorable outcome of the patients. Women with high p27 expression had a significantly longer disease-free survival (adjusted hazard ratio for relapse, 0.22; 95\% confidence interval, 0.11-0.42; P {\textless} 0.001) and overall survival (adjusted hazard ratio for death, 0.39; 95\% confidence interval, 0.21-0.72; P = 0.002) as compared with women with low p27 expression. CONCLUSION: Low p27 expression independently predicts early relapse and death in postmenopausal women with early-stage, hormone receptor-positive breast cancer who received adjuvant tamoxifen for 5 years.},
	number = {18},
	urldate = {2010-04-20},
	journal = {Clinical Cancer Research: An Official Journal of the American Association for Cancer Research},
	author = {Filipits, Martin and Rudas, Margaretha and Heinzl, Harald and Jakesz, Raimund and Kubista, Ernst and Lax, Sigurd and Schippinger, Walter and Dietze, Otto and Greil, Richard and Stiglbauer, Wolfgang and Kwasny, Werner and Nader, Alexander and Stierer, Michael and Gnant, Michael F X},
	month = sep,
	year = {2009},
	pmid = {19723645},
	keywords = {Aged, Antineoplastic Agents, Hormonal, Breast Neoplasms, Chemotherapy, Adjuvant, Cyclin-Dependent Kinase Inhibitor p27, Female, Follow-Up Studies, Humans, Immunohistochemistry, Kaplan-Meiers Estimate, Middle Aged, Multivariate Analysis, Postmenopause, Predictive Value of Tests, Prognosis, Receptors, Progesterone, Recurrence, Survival Analysis, Survival Rate, Tamoxifen, Treatment Outcome},
	pages = {5888--5894},
}

Paper  abstract   bibtex   

@article{
 id = {8364c8e1-57a1-3484-94df-1bd37d5d7010},
 title = {Nonlinear measure of synchrony between blood oxygen saturation and heart rate from nocturnal pulse oximetry in obstructive sleep apnoea syndrome.},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Aged, 80 and over,Algorithms,Data Interpretation, Statistical,Entropy,Female,Heart Rate,Heart Rate: physiology,Humans,Male,Middle Aged,Nonlinear Dynamics,Oximetry,Oxygen,Oxygen: blood,Polysomnography,ROC Curve,Reproducibility of Results,Sleep Apnea, Obstructive,Sleep Apnea, Obstructive: blood,Sleep Apnea, Obstructive: physiopathology,Young Adult},
 created = {2012-06-13T03:54:21.000Z},
 pages = {967-82},
 volume = {30},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19696463},
 month = {9},
 accessed = {2010-08-14},
 file_attached = {true},
 profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
 group_id = {ba0deb47-e19a-3151-83cc-b6262d5edb6e},
 last_modified = {2014-07-19T19:17:42.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Alvarez2009b},
 client_data = {"desktop_id":"5adc2c25-73db-4b77-aed2-d32a75858a27"},
 abstract = {This study focuses on analysis of the relationship between changes in blood oxygen saturation (SaO(2)) and heart rate (HR) recordings from nocturnal pulse oximetry (NPO) in patients suspected of suffering from obstructive sleep apnoea (OSA) syndrome. Two different analyses were developed: a classical frequency analysis based on the magnitude squared coherence (MSC) and a nonlinear analysis by means of a recently developed measure of synchrony, the cross-approximate entropy (cross-ApEn). A data set of 187 subjects was studied. We found significantly higher correlation and synchrony between oximetry signals from OSA positive patients compared with OSA negative subjects. We assessed the diagnostic ability to detect OSA syndrome of both the classical and nonlinear approaches by means of receiver operating characteristic (ROC) analyses with tenfold cross-validation. The nonlinear measure of synchrony significantly improved the results obtained with classical MSC: 69.2% sensitivity, 90.9% specificity and 78.1% accuracy were reached with MSC, whereas 83.7% sensitivity, 84.3% specificity and 84.0% accuracy were obtained with cross-ApEn. Our results suggest that the use of nonlinear measures of synchrony could provide essential information from oximetry signals, which cannot be obtained with classical spectral analysis.},
 bibtype = {article},
 author = {Alvarez, D and Hornero, R and Abásolo, D and del Campo, F and Zamarrón, C and López, M},
 journal = {Physiological measurement},
 number = {9}
}

@article{watts_prevalence_2009,
	title = {Prevalence and incidence of {Wegener}'s granulomatosis in the {UK} general practice research database},
	volume = {61},
	issn = {0004-3591},
	doi = {10.1002/art.24544},
	abstract = {OBJECTIVE: Wegener's granulomatosis (WG) is a systemic vasculitis of unknown etiology. The UK General Practice Research Database (GPRD) contains the complete primary care records of approximately 3.6 million people. There are no data on the incidence and prevalence of WG from primary care. The aim of the study was to estimate the incidence and prevalence of WG in the GPRD population.
METHODS: We identified all patients who had a first diagnosis of WG during 1990-2005, using Oxford Information System and Read codes. The diagnosis was verified by review of a randomly selected sample of 35 records that had identifying data removed. The annual incidence was calculated as the number of incident cases divided by the total person-years.
RESULTS: A total of 295 patients (51.2\% male) with a first diagnosis of WG were identified during 1990-2005. The median age was 59 years (interquartile range 47-70 years). The overall annual incidence of WG was 8.4 per million (95\% confidence interval [95\% CI] 7.5-9.4). The annual rate in women and men was 8.1 per million (95\% CI 6.8-9.6), and 8.8 per million (95\% CI 7.4-10.3), respectively. The incidence was stable throughout the study period. There was an increase in the annual prevalence from 28.8 per million in 1990 to 64.8 per million in 2005. The diagnosis was verified in 28 of 31 available case records.
CONCLUSION: This is the first study of the incidence and prevalence of WG in a database from a primary care population. The results are similar to previous studies from secondary and tertiary care and suggest that these studies are representative of the general population. The increasing prevalence with a constant incidence suggests that survival is improving with modern treatment protocols.},
	language = {eng},
	number = {10},
	journal = {Arthritis and Rheumatism},
	author = {Watts, Richard A. and Al-Taiar, Abdullah and Scott, David G. I. and Macgregor, Alex J.},
	month = oct,
	year = {2009},
	pmid = {19790134},
	keywords = {Aged, Databases, Factual, Female, Granulomatosis with polyangiitis, Great Britain, Humans, Male, Middle Aged, Prevalence, Primary Health Care, incidence},
	pages = {1412--1416}
}

@article{setakis_changes_2008,
	title = {Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib},
	volume = {59},
	issn = {0004-3591},
	doi = {10.1002/art.23925},
	abstract = {OBJECTIVE: To evaluate the impact of rofecoxib withdrawal on the characteristics of patients prescribed selective cyclooxygenase 2 (COX-2) inhibitors.
METHODS: The General Practice Research Database was used to identify patients age {\textgreater} or =18 years who were prescribed a selective COX-2 inhibitor. Various patient characteristics were noted at the start of therapy: age, sex, nonsteroidal antiinflammatory drug-related risk factors for upper gastrointestinal (GI) events, and the Framingham risk score for cardiovascular disease. Logistic regression was used to compare patients using selective COX-2 inhibitors before and after September 2004.
RESULT: The study population included 171,645 patients receiving selective COX-2 inhibitors. The number of users substantially increased over time until September 2004 and sharply declined thereafter. Approximately 80\% stopped selective COX-2 inhibitor therapy within 6 months. Patients receiving selective COX-2 inhibitors after September 2004 were younger and included more men compared with those receiving therapy before September 2004. There was no change before and after September 2004 in the proportion of patients with GI risk factors or high Framingham risk scores, after adjustment for age and sex. A correlation was found between presence of GI risk factors and high Framingham risk scores. Only 20\% of patients receiving selective COX-2 inhibitors had GI risk factors but low Framingham risk score, which did not change after September 2004.
CONCLUSION: There was no channeling in the usage of selective COX-2 inhibitors toward patients with a high risk of GI and low risk of cardiovascular disease following the withdrawal of rofecoxib.},
	language = {eng},
	number = {8},
	journal = {Arthritis and Rheumatism},
	author = {Setakis, E. and Leufkens, H. G. M. and van Staa, T. P.},
	month = aug,
	year = {2008},
	pmid = {18668614},
	keywords = {Adolescent, Adult, Aged, Cardiovascular Diseases, Cyclooxygenase 2 Inhibitors, Databases, Factual, Drug Prescriptions, Drug Utilization Review, Female, Gastrointestinal Diseases, Great Britain, Humans, Lactones, Logistic Models, Male, Middle Aged, Rheumatic Diseases, Risk Factors, Sulfones, incidence},
	pages = {1105--1111}
}

@article{haute_autorite_de_santee_has_diagnosis_2008,
	title = {[{Diagnosis} and management of {Alzheimer}'s disease and related diseases]},
	volume = {164},
	issn = {0035-3787},
	doi = {10.1016/j.neurol.2008.06.007},
	language = {fre},
	number = {8-9},
	journal = {Revue Neurologique},
	author = {{Haute Autorité de Santée (HAS)}},
	month = sep,
	year = {2008},
	pmid = {19031533},
	keywords = {Aged, Alzheimer Disease, Humans, Neurodegenerative Diseases, Neuropsychological Tests, Survival Analysis, Psychiatric Status Rating Scales, Electroencephalography, Mental Disorders, Diagnosis, Differential, Early Diagnosis, Patient Education as Topic, Terminology as Topic},
	pages = {754--774}
}

@article{boussekey_pilot_2008,
	title = {A pilot randomized study comparing high and low volume hemofiltration on vasopressor use in septic shock.},
	volume = {34},
	issn = {0342-4642 0342-4642},
	doi = {10.1007/s00134-008-1127-3},
	abstract = {OBJECTIVE: High volume hemofiltration (HVHF) has shown potential benefits in septic animals and a few reports suggested a hemodynamic improvement in humans. However, randomized studies are still lacking. Our goal was to evaluate the hemodynamic effects of HVHF in septic shock patients with acute renal failure (ARF). DESIGN AND SETTING: Prospective randomized study in an intensive care unit (ICU). PATIENTS: Twenty patients with septic shock and ARF. INTERVENTIONS: Patients were randomized to either high volume hemofiltration [HVHF 65 ml/(kg h)] or low volume hemofiltration [LVHF 35 ml/(kg h). Vasopressor dose was adjusted to reach a mean arterial pressure (MAP) {\textgreater} 65 mmHg. MEASUREMENTS AND RESULTS: We performed six hourly measurements of MAP, norepinephrine dose, PaO(2)/FiO(2) and  lactate, and four daily urine output and logistic organ dysfunction (LOD) score.  Baseline characteristics of the two groups were comparable on randomization. Mean norepinephrine dose decreased more rapidly after 24 h of HVHF treatment compared  to LVHF treatment (P = 0.004) whereas lactate and PaO(2)/FiO(2) did not differ between the two treatment groups. During the 4-day follow-up, urine output was slightly increased in the HVHF group (P = 0.059) but the LOD score evolution was  not different. Duration of mechanical ventilation, renal replacement therapy and  ICU length of stay were also comparable. Survival on day 28 was not affected. CONCLUSION: HVHF decreased vasopressor requirement and tended to increase urine output in septic shock patients with renal failure. However, a larger trial is required to confirm our results and perhaps to show a benefit in survival.},
	language = {eng},
	number = {9},
	journal = {Intensive care medicine},
	author = {Boussekey, Nicolas and Chiche, Arnaud and Faure, Karine and Devos, Patrick and Guery, Benoit and d'Escrivan, Thibaud and Georges, Hugues and Leroy, Olivier},
	month = sep,
	year = {2008},
	pmid = {18542921},
	keywords = {Humans, Adult, Female, Aged, Intensive Care Units, Male, Middle Aged, Aged, 80 and over, *Hospital Mortality, Acute Kidney Injury/*complications/*therapy, APACHE, Blood Pressure/drug effects, Hemofiltration/*methods, Norepinephrine/administration \& dosage/*therapeutic use, Respiration, Artificial, Shock, Septic/classification/*complications/*therapy, Vasoconstrictor Agents/administration \& dosage/*therapeutic use},
	pages = {1646--1653}
}

@article{annweiler_association_2008,
	title = {Association of angiitis of central nervous system, cerebral amyloid angiopathy, and {Alzheimer}'s disease: report of an autopsy case},
	volume = {4},
	issn = {1178-2048},
	shorttitle = {Association of angiitis of central nervous system, cerebral amyloid angiopathy, and {Alzheimer}'s disease},
	abstract = {The association of angiitis of central nervous system (ACNS) with cerebral amyloid angiopathy (CAA) suggests a physiopathological relationship between these two affections. Few cases are reported in patients with Alzheimer's disease (AD). We describe here a clinicopathological case associating ACNS, CAA, and AD. We discuss the aetiology of ACNS and its relationship with cerebral deposition of beta A4 amyloid protein (betaA4).},
	language = {eng},
	number = {6},
	journal = {Vascular Health and Risk Management},
	author = {Annweiler, Cédric and Paccalin, Marc and Berrut, Gilles and Hommet, Caroline and Lavigne, Christian and Saint-André, Jean-Paul and Beauchet, Olivier},
	year = {2008},
	pmid = {19337561},
	pmcid = {PMC2663463},
	keywords = {Aged, Alzheimer Disease, Amyloid beta-Peptides, Autopsy, Brain, Brain Chemistry, Cerebral Amyloid Angiopathy, Fatal Outcome, Female, Humans, Treatment Outcome, Vasculitis, Central Nervous System},
	pages = {1471--1474}
}

@article{lebert_patients_2007,
	title = {Patients characteristics with cholinesterase inhibitor resistant hallucinations in dementia with {Lewy} bodies},
	volume = {78},
	issn = {1468-330X},
	doi = {10.1136/jnnp.2007.119446},
	language = {eng},
	number = {12},
	journal = {Journal of Neurology, Neurosurgery, and Psychiatry},
	author = {Lebert, Florence and Pasquier, Florence},
	month = dec,
	year = {2007},
	pmid = {17846112},
	pmcid = {PMC2095616},
	keywords = {Aged, Cholinesterase Inhibitors, Drug Resistance, Female, Hallucinations, Humans, Lewy Body Disease, Male, Neuropsychological Tests},
	pages = {1415--1416},
}

@article{fox_prevalence_2006,
	title = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database: {A} series of retrospective analyses of data from 1998 through 2002},
	volume = {28},
	issn = {0149-2918},
	shorttitle = {Prevalence of inadequate glycemic control among patients with type 2 diabetes in the {United} {Kingdom} general practice research database},
	doi = {10.1016/j.clinthera.2006.03.005},
	abstract = {BACKGROUND: Since the mid-1990s, the development of new oral antidiabetic agents (OAs) and treatment guidelines have created an opportunity to improve glycemic control in patients with type 2 diabetes.
OBJECTIVES: This study aimed to assess the prevalence of good and inadequate glycemic control across a 5-year period among patients with diabetes in the United Kingdom. It also investigated the factors associated with achieving glycemic targets.
METHODS: This was a retrospective, cross-sectional analysis of data from the General Practice Research Database. Three limits were used to assess glycosylated hemoglobin (HbA1c): 6.5\%, 7.0\%, or 7.5\%. Values above the cutoffs indicated inadequate control of HbA1c; those at or below the cutoffs indicated good control. The study evaluated clinical and pharmacy data from the years 1998 to 2002 for patients with type 2 diabetes, {\textgreater} or =2 years of follow-up, and {\textgreater} or =2 HbA1c measurements during the first year. Five independent cross-sectional analyses were conducted, grouping data by year. Statistical significance was determined by Student t and chi2 tests.
RESULTS: Data were analyzed for 10,663 patients aged 17 to 98 years. The number of total eligible type 2 diabetes patients increased over the course of the study period: 5674 patients in 1998, 6553 in 1999, 7314 in 2000, 7323 in 2001, and 6192 in 2002. Overall, the study population had a mean (SD) age of 66 (11.0) years, was 53\% male (3033/5674), and had a body mass index of 29 kg/m(2). Seventy-six percent of patients had HbA1c {\textgreater}7.0\% and 37\% were taking {\textgreater} or =2 oral agents. In 1998 and 2002, 79\% (4482/5674) and 76\% (4732/6192) of patients, respectively, had inadequate glycemic control, defined as HbA1c {\textgreater}7.0\%. When defined as HbA1c {\textgreater}7.5\%, 69\% (3923/5674) and 62\% (3814/6192) of patients, respectively, had inadequate control. Finally, when defined as HbA1c {\textgreater}6.5\%, 88\% (5011/5674) of patients in both 1998 and 2002 had inadequate control. Compared with patients with good disease control (HbA1c {\textless} or =7.0\%), patients with inadequate control were approximately 2 years younger (P {\textless} 0.001) and had been prescribed more OAs: 41\% received {\textgreater} or =2 OAs in 1998 and 52\% in 2002, compared with 23\% and 34\% (both, P = 0.001), respectively, of patients with good glycemic control (P {\textless} 0.02). Sex, number of diabetes complications, and number of comorbidities did not differ between groups (P = NS).
CONCLUSIONS: Despite the introduction of new OAs and treatment guidelines, the prevalence of inadequate glycemic control remains high ({\textgreater}60\%) in patients with type 2 diabetes in the United Kingdom. Regardless of the HbA1c cutoff, patients with inadequate control were younger and received prescriptions for more OAs than patients with good control.},
	language = {eng},
	number = {3},
	journal = {Clinical Therapeutics},
	author = {Fox, Kathleen M. and Gerber Pharmd, Robert A. and Bolinder, Bjorn and Chen, Jack and Kumar, Sanjaya},
	month = mar,
	year = {2006},
	pmid = {16750453},
	keywords = {Administration, Oral, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Family Practice, Female, Great Britain, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Prevalence, Retrospective Studies, databases as topic},
	pages = {388--395}
}

@article{shepherd_comparison_2006,
	title = {Comparison of {BMD} precision for {Prodigy} and {Delphi} spine and femur scans},
	volume = {17},
	issn = {0937-941X},
	doi = {10.1007/s00198-006-0127-9},
	abstract = {INTRODUCTION: Precision error in bone mineral density (BMD) measurement can be affected by patient positioning, variations in scan analysis, automation of software, and both short- and long-term fluctuations of the densitometry equipment. Minimization and characterization of these errors is essential for reliable assessment of BMD change over time.
METHODS: We compared the short-term precision error of two dual-energy X-ray absorptiometry (DXA) devices: the Lunar Prodigy (GE Healthcare) and the Delphi (Hologic). Both are fan-beam DXA devices predominantly used to measure BMD of the spine and proximal femur. In this study, 87 women (mean age 61.6+/-8.9 years) were measured in duplicate, with repositioning, on both systems, at one of three clinical centers. The technologists were International Society for Clinical Densitometry (ISCD) certified and followed manufacturer-recommended procedures. All scans were acquired using 30-s scan modes. Precision error was calculated as the root-mean-square standard deviation (RMS-SD) and coefficient of variation (RMS-\%CV) for the repeated measurements. Right and left femora were evaluated individually and as a combined dual femur precision. Precision error of Prodigy and Delphi measurements at each measurement region was compared using an F test to determine significance of any observed differences.
RESULTS: While precision errors for both systems were low, Prodigy precision errors were significantly lower than Delphi at L1-L4 spine (1.0\% vs 1.2\%), total femur (0.9\% vs 1.3\%), femoral neck (1.5\% vs 1.9\%), and dual total femur (0.6\% vs 0.9\%). Dual femur modes decreased precision errors by approximately 25\% compared with single femur results.
CONCLUSIONS: This study suggests that short-term BMD precision errors are skeletal-site and manufacturer specific. In clinical practice, precision should be considered when determining: (a) the minimum time interval between baseline and follow-up scans and (b) whether a statistically significant change in the patient's BMD has occurred.},
	language = {eng},
	number = {9},
	journal = {Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA},
	author = {Shepherd, J. A. and Fan, B. and Lu, Y. and Lewiecki, E. M. and Miller, P. and Genant, H. K.},
	year = {2006},
	pmid = {16823544},
	keywords = {Absorptiometry, Photon, Aged, Aged, 80 and over, Bone Density, Female, Femur, Femur Neck, Hip Joint, Humans, Lumbar Vertebrae, Middle Aged, Osteoporosis, Postmenopausal, Postmenopause, Reproducibility of Results},
	pages = {1303--1308}
}

@Article{Rasouli_2006_906,
  author = {Rasouli, M.L. and Shavelle, D.M. and French, W.J. and McKay, C.R. and Budoff, M.J.},
 journal = {Coronary Artery Dispatch},
 note = {0954-6928 (Print) Clinical Trial Comparative Study Journal Article Research Support, Non-U.S. Gov't},
 number = {4},
 pages = {359-364},
 title = {Assessment of coronary plaque morphology by contrast-enhanced computed tomographic angiography: {C}omparison with intravascular ultrasound},
 volume = {17},
 year = {2006},
 keywords = {Contrast, Media, Coronary, Angiography/*methods, Coronary, Arteriosclerosis/*radiography/*ultrasonography, Coronary, Vessels/pathology/ultrasonography, Female, Humans, Image, Processing, Computer-Assisted, Male, Middle, Aged, Tomography, X-Ray, Computed/*methods, Ultrasonography, Interventional/*methods},
 title_with_no_special_chars = {Assessment of coronary plaque morphology by contrastenhanced computed tomographic angiography Comparison with intravascular ultrasound}
}

@article{hernan_nonsteroidal_2006,
	title = {Nonsteroidal anti-inflammatory drugs and the incidence of {Parkinson} disease},
	volume = {66},
	issn = {1526-632X},
	doi = {10.1212/01.wnl.0000204446.82823.28},
	abstract = {Animal and epidemiologic studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the incidence of Parkinson disease (PD). The authors studied 1,258 PD cases and 6,638 controls from the General Practice Research Database. The odds ratios (95\% CI) for ever vs never use were 0.93 (0.80 to 1.08) for nonaspirin NSAIDs, 1.29 (1.05 to 1.58) for aspirin, and 1.16 (1.00 to 1.35) for acetaminophen. Nonaspirin NSAID use was associated with a higher risk in women and a lower risk in men.},
	language = {eng},
	number = {7},
	journal = {Neurology},
	author = {Hernán, Miguel A. and Logroscino, Giancarlo and García Rodríguez, Luis A.},
	month = apr,
	year = {2006},
	pmid = {16606925},
	keywords = {Acetaminophen, Aged, Anti-Inflammatory Agents, Non-Steroidal, Antiparkinson Agents, Aspirin, Case-Control Studies, Cohort Studies, Databases, Factual, Family Practice, Female, Great Britain, Humans, Male, Parkinson Disease, Sex Characteristics, Tremor, incidence},
	pages = {1097--1099}
}

@article{frank_effects_2005,
	title = {Effects of compulsory treatment orders on time to hospital readmission},
	volume = {56},
	issn = {1075-2730},
	doi = {10.1176/appi.ps.56.7.867},
	abstract = {To evaluate the effect of compulsory community treatment orders on subsequent time out of the hospital, the authors studied the admission dates of psychotic patients who had repeated hospitalizations in Quebec, Canada, and divided each admission according to its time in relation to the index admission, during which the judicial order was obtained. The data were stratified by type of admission (early, preindex, index, or postindex), and the hypothesis tested was that the median time to readmission would be greatest for the index admission. The hypothesis was confirmed, supporting previous findings that judicial orders that mandate severely ill psychotic patients to undergo compulsory community treatment are associated with decreased time spent in the hospital and thus increased personal freedom.},
	language = {eng},
	number = {7},
	journal = {Psychiatric Services (Washington, D.C.)},
	author = {Frank, Daniel and Perry, J. Christopher and Kean, Dana and Sigman, Maxine and Geagea, Khalil},
	month = jul,
	year = {2005},
	pmid = {16020822},
	keywords = {Adult, Aged, Aged, 80 and over, Commitment of Mentally Ill, Community Mental Health Services, Female, Follow-Up Studies, Hospitalization, Humans, Male, Mental Disorders, Middle Aged, Patient Admission, Quebec, Time Factors, Treatment Outcome},
	pages = {867--869},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Biological evidence for inheritance of exceptional longevity},
 type = {article},
 year = {2005},
 identifiers = {[object Object]},
 keywords = {Age Factors,Aged,Aged, 80 and over,Aging/*ethnology/*genetics,Alleles,Carrier Proteins/genetics,Case-Control Studies,Genotype,Glycoproteins/genetics,Homozygote,Humans,Lipids/metabolism,Lipoproteins, HDL/genetics/metabolism,Lipoproteins, LDL/genetics/metabolism,Longevity/*genetics,Phenotype,Polymorphism, Genetic,Valine/genetics},
 pages = {341-345},
 volume = {126},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15621216},
 id = {ac53ce7e-fc6c-35da-8438-be74b645fce9},
 created = {2017-06-19T13:45:30.857Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:45:31.024Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0047-6374<m:linebreak/>Journal Article</m:note>},
 abstract = {Subjects with exceptional longevity have a lower incidence and/or significant delay in the onset of age-related disease, and their family members may inherit biological factors that modulate aging processes and disease susceptibility. In a case control study, we aim to determine phenotype and genotype of exceptional longevity in a genetically homogenous population (Ashkenazi Jews), and their offspring, while an age-matched control group of Ashkenazi Jews was used as control groups. We demonstrated that exceptional longevity and healthy aging in humans is an inherited phenotype across three generations. Moreover, we demonstrated that subjects with exceptional longevity and their offspring have significantly larger high-density lipoprotein (HDL) levels and particle sizes and low-density lipoprotein (LDL) levels that reflect on their health and cognitive function performance. This phenotype have led us to study candidate genes involved in lipoprotein metabolism, and to the implication of homozygosity for the 405 valine (V) allele of cholesteryl ester transfer protein (CETP). A markedly higher frequency of a functional CETP variant that led to increased particle sizes of HDL and LDL and thus a better health performance is the first example of a phenotype and an associated genotype in humans with exceptional longevity. Hopefully, this line of research will lead us to establish which genotype is necessary (although not necessary sufficient) for a prolonged disease-free aging.},
 bibtype = {article},
 author = {Atzmon, G and Rincon, M and Rabizadeh, P and Barzilai, N},
 journal = {Mech Ageing Dev},
 number = {2}
}

@Article{Weber_2005_1074,
  author = {Weber, C. and Begemann, P. and Wedegartner, U. and Meinertz, T. and Adam, G.},
 journal = {Rofo},
 note = {1438-9029 (Print) Comparative Study English Abstract Journal Article},
 number = {1},
 pages = {50--9},
 title = {Calcium scoring and coronary angiography performed with multislice spiral CT - clinical experience},
 volume = {177},
 year = {2005},
 keywords = {Adult, Aged, Aged, 80, and, over, Calcinosis/diagnosis/*radiography, Chi-Square, Distribution, *Coronary, Angiography, Coronary, Arteriosclerosis/diagnosis/radiography, Coronary, Disease/diagnosis/*radiography, Coronary, Stenosis/diagnosis/radiography, Electrocardiography, Female, Humans, Male, Middle, Aged, Prospective, Studies, Risk, Factors, Software, Tomography, Spiral, Computed/*methods},
 title_with_no_special_chars = {Calcium scoring and coronary angiography performed with multislice spiral CT  clinical experience}
}

@article{fischer_discontinuation_2004,
	title = {Discontinuation of nonsteroidal anti-inflammatory drug therapy and risk of acute myocardial infarction},
	volume = {164},
	issn = {0003-9926},
	doi = {10.1001/archinte.164.22.2472},
	abstract = {BACKGROUND: Systemic inflammation has been shown to be associated with an increased risk of acute myocardial infarction (AMI). However, the effect of the use of nonsteroidal anti-inflammatory drugs (NSAIDs) on the risk of AMI has not yet been well defined. We therefore studied the risk of AMI during NSAID exposure and after the cessation of NSAID therapy.
METHODS: We conducted a large case-control analysis on the British General Practice Research Database. The study included 8688 cases with a first-time AMI between 1995 and 2001 and 33 923 controls, matched to cases on age, sex, calendar time, and general practice attended.
RESULTS: After adjusting for hypertension, hyperlipidemia, diabetes mellitus, ischemic heart disease, rheumatoid arthritis, systemic lupus erythematosus, acute chest infection, body mass index, smoking, and aspirin use, the risk of AMI was 1.52 (95\% confidence interval [CI], 1.33-1.74) for subjects who stopped taking NSAIDs 1 to 29 days prior to the index date, compared with nonusers. The risk was highest in subjects with rheumatoid arthritis or systemic lupus erythematosus (adjusted OR, 3.68 [95\% CI, 2.36-5.74]) and for subjects who discontinued therapy with NSAIDs after previous long-term use (adjusted OR, 2.60 [95\% CI, 1.84-3.68]). Current and past NSAID use (discontinued therapy {\textgreater}/=60 days prior to the index date) were not associated with an increased risk of AMI (adjusted OR, 1.07 [95\% CI, 0.96-1.19] and 1.05 [95\% CI, 0.99-1.12], respectively).
CONCLUSION: Our findings suggest that the risk of AMI is increased during several weeks after the cessation of NSAID therapy.},
	language = {eng},
	number = {22},
	journal = {Archives of Internal Medicine},
	author = {Fischer, Lorenz M. and Schlienger, Raymond G. and Matter, Christian M. and Jick, Hershel and Meier, Christoph R.},
	month = dec,
	year = {2004},
	pmid = {15596638},
	keywords = {Aged, Aged, 80 and over, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Rheumatoid, Female, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Myocardial Infarction, Substance Withdrawal Syndrome},
	pages = {2472--2476}
}

Paper  doi  abstract   bibtex   

@article{lohmander_high_2004,
	title = {High prevalence of knee osteoarthritis, pain, and functional limitations in female soccer players twelve years after anterior cruciate ligament injury.},
	volume = {50},
	issn = {0004-3591},
	url = {http://dx.doi.org/10.1002/art.20589},
	doi = {10.1002/art.20589},
	abstract = {OBJECTIVE: To determine the prevalence of radiographic knee osteoarthritis (OA) as well as knee-related symptoms and functional limitations in female soccer players 12 years after an anterior cruciate ligament (ACL) injury.
METHODS: Female soccer players who sustained an ACL injury 12 years earlier were examined with standardized weight-bearing knee radiography and 2 self-administered patient questionnaires, the Knee Injury and Osteoarthritis Outcome Score questionnaire and the Short Form 36-item health survey. Joint space narrowing and osteophytes were graded according to the radiographic atlas of the Osteoarthritis Research Society International. The cutoff value to define radiographic knee OA approximated a Kellgren/Lawrence grade of 2.
RESULTS: Of the available cohort of 103 female soccer players, 84 (82\%) answered the questionnaires and 67 (65\%) consented to undergo knee radiography. The mean age at assessment was 31 years (range 26-40 years) and mean body mass index was 23 kg/m2 (range 18-40 kg/m2). Fifty-five women (82\%) had radiographic changes in their index knee, and 34 (51\%) fulfilled the criterion for radiographic knee OA. Of the subjects answering the questionnaires, 63 (75\%) reported having symptoms affecting their knee-related quality of life, and 28 (42\%) were considered to have symptomatic radiographic knee OA. Slightly more than 60\% of the players had undergone reconstructive surgery of the ACL. Using multivariate analyses, surgical reconstruction was found to have no significant influence on knee symptoms.
CONCLUSION: A very high prevalence of radiographic knee OA, pain, and functional limitations was observed in young women who sustained an ACL tear during soccer play 12 years earlier. These findings constitute a strong rationale to direct increased efforts toward prevention and better treatment of knee injury.},
	language = {eng},
	number = {10},
	journal = {Arthritis and Rheumatism},
	author = {Lohmander, L. S. and Ostenberg, A. and Englund, M. and Roos, H.},
	month = oct,
	year = {2004},
	pmid = {15476248},
	keywords = {Adult, Aged, Anterior Cruciate Ligament, Female, Humans, Knee, Middle Aged, Multivariate Analysis, Osteoarthritis, Knee, Pain, Prevalence, Quality of Life, Soccer, Surveys and Questionnaires, Time Factors},
	pages = {3145--3152},
}

Website  abstract   bibtex   

@article{
 title = {Genetic factors in longevity},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {*Polymorphism,Aged,Apolipoproteins E/genetics,English Abstract,Environment,Genetic,Genetic Markers,Humans,Longevity/*genetics,Middle Aged,Twin Studies},
 pages = {365-369},
 volume = {32},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12712685},
 id = {362160a5-7ac7-38b4-a59b-5cbf995c24d1},
 created = {2017-06-19T13:43:48.429Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:48.541Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0755-4982<m:linebreak/>Journal Article</m:note>},
 abstract = {TO IDENTIFY THE GENETIC FACTORS: Family and twin studies showed that longevity results from the interaction of genetic and environmental factors. Despite progress the performed made in the study of animal models highlighting some interesting metabolic pathways, characterization of genetic factors remains difficult in human beings. Two genetic approaches are currently available: association studies and sib-pair analyses. ASSOCIATION STUDIES: The first method is based on the comparison of polymorphism repartitions on candidate genes in two matched populations of old people and young controls. SIB-PAIR ANALYSES: The second requires genotyping of brothers and/or sisters on a set of highly polymorphic markers, in order to identify new candidate regions on the genome. APOE: Until now, the only gene that remains clearly associated with longevity is the Apolipoprotein E gene.},
 bibtype = {article},
 author = {Blanche, H},
 journal = {Presse Med},
 number = {8}
}

@article{peyriere_adverse_2003,
	title = {Adverse drug events associated with hospital admission},
	volume = {37},
	issn = {1060-0280},
	abstract = {OBJECTIVE: To increase the knowledge base on the frequency, causality, and avoidability of adverse drug events (ADEs) as a cause for admission in internal medicine or when occurring during hospitalization.
METHODS: A prospective study was performed for 6 periods of 8 days each. Epidemiologic data (e.g., age, gender, medical history), drug utilization, and adverse drug reactions on patients hospitalized during these periods were collected by a pharmacy student.
RESULTS: A total of 156 patients (70 men and 86 women) were included in the study. The patients' mean age +/- SD was 66.5 +/- 18.1 years and mean length of stay was 13.2 +/- 9 days. Renal and hepatic insufficiency and previous history of drug intolerance were observed in 17.9\%, 10.2\%, and 2\% of the hospitalized patients, respectively. Thirty-eight ADEs occurred in 32 patients; in 15 cases, ADEs were identified as the reason for admission, 10 cases occurred during hospitalization, and 13 cases were present at admission, but were not the cause of admission. The most frequent ADEs involved the neurologic (23.6\%), renal (15.7\%), and hematologic (13.1\%) systems. Among these 38 ADEs, 22 were considered avoidable (57.9\%); 20 of these were associated with therapeutic errors (inappropriate administration, drug-drug interactions, dosage error, drug not stopped despite the onset of ADEs). Patients with ADEs stayed longer in the hospital and took more drugs both before and during their hospital stay (p {\textless} 0.05).
CONCLUSIONS: Most of the ADEs observed in this study were avoidable. The risk/benefit ratio of administered drugs could be improved with better knowledge of the patients' medical history and the risk factors of ADEs.},
	language = {eng},
	number = {1},
	journal = {The Annals of Pharmacotherapy},
	author = {Peyriere, Hélène and Cassan, Stéphanie and Floutard, Edith and Riviere, Sophie and Blayac, Jean-Pierre and Hillaire-Buys, Dominique and Le Quellec, Alain and Hansel, Sylvie},
	month = jan,
	year = {2003},
	pmid = {12503925},
	keywords = {Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Drug Hypersensitivity, Drug-Related Side Effects and Adverse Reactions, Female, Hospitalization, Humans, Length of Stay, Male, Medication Errors, Middle Aged, Pharmacy Service, Hospital, Prospective Studies, Risk Factors},
	pages = {5--11}
}

@Article{Ridker_2002_1393,
  author = {Ridker, P.M. and Rifai, N. and Rose, L. and Buring, J.E. and Cook, N.R.},
 journal = {New England Journal of Medicine},
 note = {Hl-43851/hl/nhlbi Hl-58755/hl/nhlbi Hl-63293/hl/nhlbi Comparative Study Evaluation Studies Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United States},
 number = {20},
 pages = {1557-1565},
 title = {Comparison of {C}-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events},
 volume = {347},
 year = {2002},
 keywords = {Aged, Biological, Markers/blood, C-Reactive, Protein/*analysis, Cardiovascular, Diseases/blood/*epidemiology, Cholesterol, LDL/*blood, Disease-Free, Survival, Female, Hormone, Replacement, Therapy, Humans, Incidence, Longitudinal, Studies, Middle, Aged, Multivariate, Analysis, Prognosis, ROC, Curve, Risk, Risk, Factors},
 title_with_no_special_chars = {Comparison of Creactive protein and lowdensity lipoprotein cholesterol levels in the prediction of first cardiovascular events}
}

@article{schlienger_use_2002,
	title = {Use of nonsteroidal anti-inflammatory drugs and the risk of first-time acute myocardial infarction},
	volume = {54},
	issn = {0306-5251},
	abstract = {AIMS: Aspirin decreases the risk of clinical manifestations of atherothrombosis. This effect is mainly due to inhibition of platelet aggregation and potentially due to anti-inflammatory properties of aspirin. To evaluate whether use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) may also be associated with a decreased risk of first-time acute myocardial infarction (AMI), we performed a population-based case-control analysis using the United Kingdom-based General Practice Research Database (GPRD) METHODS: We identified first-time AMI-patients free of preexisting diagnosed cardiovascular or metabolic diseases. We compared use of NSAIDs prior to the index date between cases and control patients who were matched to cases on age, gender, practice and calendar time.
RESULTS: A total of 3319 cases ({\textless}or=75 years) with a diagnosis of first-time AMI between 1992 and 1997 and 13139 controls (matched to cases on age, sex, general practice attended, calendar time, years of prior history in the GPRD) were included. Overall, the relative risk estimate of AMI (adjusted for smoking, body mass index, hormone replacement therapy and aspirin) in current NSAID users was 1.17 (95\% CI 0.99, 1.37). Long-term current NSAID use ({\textgreater}or=30 prescriptions) yielded an adjusted odds ratio (OR) of 1.20 (95\% CI 0.94, 1.55). Stratification by age ({\textless}65 years vs{\textgreater}or=65 years) and sex did not materially change the results.
CONCLUSIONS: Our findings indicate that current NSAID exposure in patients free of diagnosed cardiovascular or metabolic conditions predisposing to cardiovascular diseases does not decrease the risk of AMI.},
	language = {eng},
	number = {3},
	journal = {British Journal of Clinical Pharmacology},
	author = {Schlienger, Raymond G. and Jick, Hershel and Meier, Christoph R.},
	month = sep,
	year = {2002},
	pmid = {12236854},
	pmcid = {PMC1874430},
	keywords = {Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Female, Great Britain, Humans, Male, Middle Aged, Myocardial Infarction, Risk Assessment, Risk Factors},
	pages = {327--332}
}

Paper  doi  bibtex   

@article{leroy_o_HOSPITALACQUIRED_2002,
title = {Hospital-acquired pneumonia: microbiological data and potential adequacy of antimicrobial regimens},
volume = {20},
issn = {0903-1936},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12212978},
DOI = {10.1183/09031936.02.00267602},
Language = {English},
Journal = {Eur. Resp. J.},
author = {{Leroy O} and {Giradie P} and {Yazdanpanah Y} and {Georges H} and {Alfandari S} and {Sanders V} and {Devos P} and {Beaucaire G}},
year = {2002},
keywords = {Aged, Anti-Bacterial Agents/therapeutic use*, Cross Infection/drug therapy*, Cross Infection/etiology, Cross Infection/microbiology*, Female, Gram-Negative Bacteria/drug effects*, Gram-Negative Bacteria/isolation & purification*, Humans, Male, Middle Aged, Outcome Assessment, Health Care, Pneumonia/drug therapy*, Pneumonia/etiology, Pneumonia/microbiology*, Retrospective Studies, Risk Factors, Severity of Illness Index, Time Factors},
pages = {432-439}
}

Paper  Website  abstract   bibtex   

@article{
 title = {The dementias.},
 type = {article},
 year = {2002},
 identifiers = {[object Object]},
 keywords = {Age Distribution,Aged,Alzheimer Disease,Alzheimer Disease: etiology,Alzheimer Disease: genetics,Alzheimer Disease: mortality,Cholinesterase Inhibitors,Cholinesterase Inhibitors: therapeutic use,Dementia,Dementia: classification,Dementia: epidemiology,Dementia: physiopathology,Female,Humans,Lewy Body Disease,Lewy Body Disease: drug therapy,Lewy Body Disease: physiopathology,Long-Term Care,Male,Molecular Biology,Prevalence,Sex Distribution},
 pages = {1759-66},
 volume = {360},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/12480441},
 month = {11},
 day = {30},
 id = {cca45e46-8add-385a-b55b-d8f89f835359},
 created = {2017-06-19T13:41:24.205Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:41:24.353Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Dementia affects about 5% of the elderly population over age 65 years and has an unexplained predominance in women and a low rate in some cultures. Different forms of dementia are now distinguished-Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, and dementia secondary to disease, such as AIDS dementia. However, such nosological boundaries are being re-evaluated because different dementias are believed to have common underlying neuropathology. Neurochemical and neurobiological research has led to advances in understanding causes of dementia, and functional imaging has allowed identification of possible biomarkers; from these, a range of potential treatment approaches have arisen that focus on enhancement of neurotransmitter function, intervention at the level of amyloid production and deposition, and reduction of secondary risk factors such as hypertension, depression, and hypolipidaemia. Molecular diagnostic testing and genetic counselling for families with autosomal dominant early-onset dementia are new developments; however, this approach is not useful for late-onset dementia, in which the identified candidate susceptibility genes have a relatively small effect on risk. While fundamental research works towards new biological treatment strategies, much remains to be done in the area of disease management and the development of appropriate models of long-term care.},
 bibtype = {article},
 author = {Ritchie, Karen and Lovestone, Simon},
 journal = {Lancet},
 number = {9347}
}

Paper  doi  abstract   bibtex   

@article{mendez_posterior_2002,
	title = {Posterior cortical atrophy: clinical characteristics and differences compared to {Alzheimer}'s disease},
	volume = {14},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12053130},
	doi = {10/frtbxr},
	abstract = {BACKGROUND: Predominant and progressive complex visual disorders are often due to posterior cortical atrophy (PCA), a rare early-onset dementing syndrome presenting with visual complaints. In clinicopathological studies, PCA is most commonly considered a form of Alzheimer's disease (AD); no prior study has evaluated clinical differences between PCA and AD. METHODS: This study identified 15 patients who presented with progressive complex visual disorders and predominant occipitoparietal hypoperfusion on SPECT. These patients were retrospectively compared on clinical variables with 30 patients with clinically probable AD matched for gender, age and duration of illness. RESULTS: The PCA patients presented with alexia, elements of Balint's syndrome, apperceptive visual agnosia, dressing apraxia and environmental disorientation along with elements of Gerstmann's syndrome. Compared to the AD patients, the 15 PCA patients (mean age of onset 58 years, range 51-64) had significantly better verbal fluency, less memory difficulty, more depression and greater insight into their illness but similar familial and apolipoprotein E risk factors. In the PCA patients, MRI often showed occipitoparietal atrophy without detectable mesiotemporal atrophy. CONCLUSIONS: PCA is a distinct clinical syndrome and not just AD with prominent visual deficits. Compared to AD controls, PCA patients have better language and memory but more insight and depression and more posterior atrophy on MRI. These results indicate clinical criteria for the diagnosis of PCA and recommend specific interventions such as visual aids and antidepressant medications. Similar risk factors and course suggest that PCA is most commonly an early-onset posteriorly shifted AD variant.},
	number = {1},
	journal = {Dement Geriatr Cogn Disord},
	author = {Mendez, M.F. and Ghajarania, M. and Perryman, K.M.},
	year = {2002},
	keywords = {Aged, Alzheimer Disease/*pathology, Atrophy/pathology, Cerebral Cortex/*pathology, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Retrospective Studies, Vision Disorders/*etiology},
	pages = {33--40},
}

@Article{Burke_2001_1516,
  author = {Burke, A. P. and Kolodgie, F. D. and Farb, A. and Weber, D. K. and Malcom, G. T. and Smialek, J. and Virmani, R.},
 journal = {Circulation},
 note = {DA - 20010222 NOT IN FILE},
 number = {7},
 pages = {934-940},
 title = {Healed plaque ruptures and sudden coronary death: {E}vidence that subclinical rupture has a role in plaque progression},
 volume = {103},
 year = {2001},
 keywords = {Arteries, Atherosclerosis, Cell, Differentiation, Cell, Division, complications, Coronary, Arteriosclerosis, Coronary, Vessels, Death, Sudden, Cardiac, Demography, epidemiology, etiology, Humans, Immunohistochemistry, Male, methods, Middle, Aged, Muscle, Smooth, Vascular, Myocardial, Infarction, Organ, Size, pathology, Research, Support, U.S.Gov't, P.H.S., Risk, Factors, Rupture, Rupture, Spontaneous, Wound, Healing},
 title_with_no_special_chars = {Healed plaque ruptures and sudden coronary death Evidence that subclinical rupture has a role in plaque progression}
}

@article{garcia_rodriguez_relative_2001,
	title = {Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs},
	volume = {12},
	issn = {1044-3983},
	abstract = {Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with an increase in upper gastrointestinal complications. There is no agreement, however, on whether all conventional NSAIDs have a similar relative risk (RR), and epidemiologic data are limited on acetaminophen. We studied the association between these medications and the risk of upper gastrointestinal bleed/perforation in a population-based cohort of 958,397 persons in the United Kingdom between 1993 and 1998. Our nested case-control analysis included 2,105 cases and 11,500 controls. RR estimates were adjusted for several factors known to be associated with upper gastrointestinal bleed/perforation. Compared with non-users, users of acetaminophen at doses less than 2 gm did not have an increased risk of upper gastrointestinal complications. The adjusted RR for acetaminophen at doses greater than 2 gm was 3.6 [95\% confidence interval (95\% CI) = 2.6-5.1]. The corresponding RRs for low/medium and high doses of NSAIDs were 2.4 (95\% CI = 1.9-3.1) and 4.9 (95\% CI = 4.1-5.8). The RR was 3.1 (95\% CI = 2.5, 3.8) for short plasma half-life, 4.5 (95\% CI = 3.5-5.9) for long half-life, and 5.4 (95\% CI = 4.0-7.1) for slow-release formulations of NSAIDs. After adjusting for daily dose, the differences in RR between individual NSAIDs tended to diminish except for apazone. Users of H2 receptor antagonists, omeprazole, and misoprostol had RRs of 1.4 (95\% CI = 1.2-1.8), 0.6 (95\% CI = 0.4-0.9), and 0.6 (95\% CI = 0.4-1.0), respectively. Among NSAID users, use of nitrates was associated with an RR of 0.6 (95\% CI = 0.4-1.0).},
	language = {eng},
	number = {5},
	journal = {Epidemiology (Cambridge, Mass.)},
	author = {García Rodríguez, L. A. and Hernández-Díaz, S.},
	month = sep,
	year = {2001},
	pmid = {11505178},
	keywords = {Acetaminophen, Adult, Aged, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Dose-Response Relationship, Drug, Female, Gastrointestinal Hemorrhage, Great Britain, Half-Life, Humans, Logistic Models, Male, Middle Aged, Peptic Ulcer, Population Surveillance, Risk, incidence},
	pages = {570--576}
}

@article{josling_preventing_2001,
	title = {Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey},
	volume = {18},
	issn = {0741-238X},
	shorttitle = {Preventing the common cold with a garlic supplement},
	doi = {10.1007/BF02850113},
	abstract = {One hundred forty-six volunteers were randomized to receive a placebo or an allicin-containing garlic supplement, one capsule daily, over a 12-week period between November and February. They used a five-point scale to assess their health and recorded any common cold infections and symptoms in a daily diary. The active-treatment group had significantly fewer colds than the placebo group (24 vs 65, P {\textless} .001). The placebo group, in contrast, recorded significantly more days challenged virally (366 vs 111, P {\textless} .05) and a significantly longer duration of symptoms (5.01 vs 1.52 days, P {\textless} .001). Consequently, volunteers in the active group were less likely to get a cold and recovered faster if infected. Volunteers taking placebo were much more likely to get more than one cold over the treatment period. An allicin-containing supplement can prevent attack by the common cold virus.},
	language = {eng},
	number = {4},
	journal = {Advances in Therapy},
	author = {Josling, P.},
	month = aug,
	year = {2001},
	pmid = {11697022},
	keywords = {Adult, Aged, Anti-Infective Agents, Common Cold, Dietary Supplements, Female, Garlic, Humans, Male, Middle Aged, Probability, Reference Values, Sulfinic Acids, Treatment Outcome},
	pages = {189--193},
}

@article{van_staa_oral_2000,
	title = {Oral corticosteroids and fracture risk: relationship to daily and cumulative doses},
	volume = {39},
	issn = {1462-0324},
	shorttitle = {Oral corticosteroids and fracture risk},
	abstract = {OBJECTIVE: This study examined the effects of daily and cumulative oral corticosteroid doses on the risk of fractures.
METHODS: Information was obtained from the General Practice Research Database, which contains medical records of general practitioners in England and Wales. The study included 244 235 oral corticosteroid users and 244 235 controls.
RESULTS: Patients taking higher doses (at least 7. 5 mg daily of prednisolone or equivalent) had significantly increased risks of non-vertebral fracture [relative rate (RR)=1.44, 95\% confidence interval (CI) 1.34-1.54], hip fracture (RR=2.21, 95\% CI 1.85-2.64) and vertebral fracture (RR=2.83, 95\% CI 2.35-2.40) relative to patients using oral corticosteroids at lower doses (less than 2.5 mg per day). Fracture risk was also elevated among people with higher cumulative exposure to oral corticosteroids over the study period, but this effect was almost wholly removed by adjustment for daily dose, age, gender and other confounding variables.
CONCLUSIONS: These findings suggest that the adverse skeletal effects of oral corticosteroids manifest rapidly and are related to daily dose. The level of previous exposure to oral corticosteroids was not a strong determinant of the risk of fracture. Preventive measures against corticosteroid-induced osteoporosis should therefore be instituted as soon after the commencement of glucocorticoid therapy as possible.},
	language = {eng},
	number = {12},
	journal = {Rheumatology (Oxford, England)},
	author = {van Staa, T. P. and Leufkens, H. G. and Abenhaim, L. and Zhang, B. and Cooper, C.},
	month = dec,
	year = {2000},
	pmid = {11136882},
	keywords = {Administration, Oral, Adrenal Cortex Hormones, Adult, Aged, Dose-Response Relationship, Drug, Female, Fractures, Bone, Humans, Middle Aged, Osteoporosis, Registries, Risk Factors},
	pages = {1383--1389}
}

@Article{Thoroughman2000,
  author   = {KA Thoroughman and R Shadmehr},
  journal  = {Nature},
  title    = {Learning of action through adaptive combination of motor primitives.},
  year     = {2000},
  number   = {6805},
  pages    = {742-7},
  volume   = {407},
  abstract = {Understanding how the brain constructs movements remains a fundamental
	challenge in neuroscience. The brain may control complex movements
	through flexible combination of motor primitives, where each primitive
	is an element of computation in the sensorimotor map that transforms
	desired limb trajectories into motor commands. Theoretical studies
	have shown that a system's ability to learn action depends on the
	shape of its primitives. Using a time-series analysis of error patterns,
	here we show that humans learn the dynamics of reaching movements
	through a flexible combination of primitives that have gaussian-like
	tuning functions encoding hand velocity. The wide tuning of the inferred
	primitives predicts limitations on the brain's ability to represent
	viscous dynamics. We find close agreement between the predicted limitations
	and the subjects' adaptation to new force fields. The mathematical
	properties of the derived primitives resemble the tuning curves of
	Purkinje cells in the cerebellum. The activity of these cells may
	encode primitives that underlie the learning of dynamics.},
  doi      = {10.1038/35037588},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, 11048700},
}

Paper  abstract   bibtex   

@article{niemeier_exploratory_2000,
	title = {Exploratory saccades show no direction-specific deficit in neglect},
	volume = {54},
	issn = {0028-3878},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/10668730},
	abstract = {In patients with spatial neglect, contralesional reflexive saccades toward suddenly appearing targets show direction-specific deficits. We examined whether these deficits also occur during free exploration of space. Neglect patients' voluntary eye movements showed reduced amplitudes for saccades in all directions but no direction-specific deficit. The results argue against an interpretation of spatial neglect as a general deficit to disengage attention or to program saccades in contralesional direction.},
	number = {2},
	urldate = {2009-01-14},
	journal = {Neurology},
	author = {Niemeier, M and Karnath, H O},
	month = jan,
	year = {2000},
	pmid = {10668730},
	keywords = {\#nosource, Aged, Attention, Darkness, Female, Fixation, Ocular, Functional Laterality, Humans, Male, Middle Aged, Parietal Lobe, Perceptual Disorders, Photic Stimulation, Saccades, Space Perception, Volition},
	pages = {515--8},
}

@article{hubbard_exposure_2000,
	title = {Exposure to antidepressants and the risk of cryptogenic fibrosing alveolitis: a case-control study},
	volume = {16},
	issn = {0903-1936},
	shorttitle = {Exposure to antidepressants and the risk of cryptogenic fibrosing alveolitis},
	abstract = {The explanations for the emergence of cryptogenic fibrosing alveolitis as a new clinical entity during the second half of the 20th century are unclear. The authors have previously reported evidence of an increased risk of cryptogenic fibrosing alveolitis in relation to the use of antidepressant drugs. The authors have now tested this hypothesis a priori in an analysis of computerized general practice records for 890 cases of cryptogenic fibrosing alveolitis and 5,884 matched controls drawn from the UK General Practice Research Database. Exposure to antidepressants at the time of diagnosis was increased in cases compared to controls (odds ratio (OR) 1.52, 95\% confidence interval (95\% CI) 1.24-1.86), and this increase remained if the analysis was restricted to exposures 4 yrs prior to diagnosis (OR 1.50, 95\% CI 0.98-2.30). However this increased prescribing was not specific to any particular class of antidepressant or individual drug, and there was no evidence of a dose-response relationship between exposure to amitriptyline (the most commonly prescribed antidepressant) and disease. The presented data do not allow any firm conclusion to be made as to whether there is a causal relationship between antidepressant exposure and cryptogenic fibrosing alveolitis, but it seems unlikely that exposure to tricyclic antidepressants shortly before diagnosis is a strong risk factor for cryptogenic fibrosing alveolitis.},
	language = {eng},
	number = {3},
	journal = {The European Respiratory Journal},
	author = {Hubbard, R. and Venn, A. and Britton, J.},
	month = sep,
	year = {2000},
	pmid = {11028652},
	keywords = {Aged, Amitriptyline, Antidepressive Agents, Antidepressive Agents, Tricyclic, Case-Control Studies, Confidence Intervals, Female, Furosemide, Humans, Male, Medical Records, Middle Aged, Pulmonary Fibrosis},
	pages = {409--413}
}

Paper  doi  abstract   bibtex   

@article{irving-bell_distortion_1999,
	title = {A distortion of perceived space in patients with right-hemisphere lesions and visual hemineglect},
	volume = {37},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10426517},
	doi = {10/drssvr},
	abstract = {In twelve patients with left visuospatial hemineglect following acute right hemisphere cerebrovascular accident (CVA), and in twelve normal controls, we used a matching task to investigate judgement of the length of lines. Their task was to choose which of three lines of different length matched a separate single line. On each trial, the lines were all vertical or all horizontal. The set of three lines was presented either to the left or the right of the single line. When the lines were vertical, the choices made both by normal subjects and patients were nearly always correct. However, when the lines were horizontal and the set of comparison lines was on the left, patients mostly selected a line that was longer than the sample on the right, and never chose shorter lines, suggesting that the length of horizontal lines on the left was underestimated. When the set of three lines was on the right, patients chose the correct line more often, but made errors in both directions, i.e. longer or shorter, although shorter lines were chosen more often than longer lines. The rare errors made by normal subjects were in the same directions as those observed in the patients. The results provide further evidence for a non-Euclidean distortion of perceptual space in patients with left sided visuospatial neglect, and suggest that this distortion could be a gross exaggeration of normal performance or a product of diminished spatial attention, or both.},
	number = {8},
	journal = {Neuropsychologia},
	author = {Irving-Bell, L. and Small, M. and Cowey, A.},
	year = {1999},
	keywords = {\#nosource, *Laterality, *Visual Perception, Aged, Attention, Brain/*pathology/physiopathology, Case-Control Studies, Cerebrovascular Disorders/*complications/pathology/physiopathology, Female, Humans, Male, Middle Aged, Perceptual Disorders/*etiology/physiopathology, Research Support, Non-U.S. Gov't, Size Perception, Space Perception},
	pages = {919--25},
}

Paper  abstract   bibtex   

@article{parrens_angiome_1998,
	title = {L'angiome à cellules littorales: une tumeur vasculaire rare de la rate [{Littoral} cell angioma: a rare vascular splenic tumor]},
	volume = {18},
	issn = {0242-6498},
	shorttitle = {[{Littoral} cell angioma},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/10051916},
	abstract = {Littoral cell angioma is a rare primitive vascular tumor of the spleen considered as benign. Its clinical presentation is non specific. The diagnostic is based on histological and immunohistological analysis. The lesion is composed of anastomosing vascular channels often featuring papillary projections. They are lined by tumoral cells which exhibit an immunoreactivity for vascular and histiomonocytic markers. We report one case of littoral cell angioma and we discuss the diagnosis and the histogenesis of this tumor.},
	number = {6},
	urldate = {2012-03-26},
	journal = {Annales De Pathologie},
	author = {Parrens, M and Nouts, C and Belleanne, G and Dubus, P and Beylot, J and de Mascarel, A},
	month = dec,
	year = {1998},
	pmid = {10051916},
	keywords = {Aged, Antigens, CD, Antigens, CD31, Antigens, Differentiation, Myelomonocytic, Factor VIII, Hemangioma, Humans, Immunohistochemistry, Male, Spleen, Splenic Neoplasms, von Willebrand Factor},
	pages = {484--487},
}

@article{van_staa_postmarketing_1998,
	title = {Postmarketing surveillance of the safety of cyclic etidronate},
	volume = {18},
	issn = {0277-0008},
	abstract = {To evaluate the safety of cyclic etidronate in routine clinical practice, we obtained information from 550 general practices in the United Kingdom that provide the medical records to the General Practice Research Database. A group of 7977 patients taking cyclic etidronate and two age-, gender-, and practice-matched control groups, one with osteoporosis and one without, were analyzed. For the group taking cyclic etidronate, the average age was 71.6 years and follow-up was 10,328 person-years. Conditions that do not induce osteoporosis generally occurred in these patients at a rate comparable to that in the control groups. The incidence of osteomalacia was low and comparable between patients taking cyclic etidronate and controls with osteoporosis. No medically significant increases in frequency were observed among patients taking cyclic etidronate for a broad group of diseases that may potentially be induced by exposure to the drug. These data support the favorable risk:benefit ratio of cyclic etidronate.},
	language = {eng},
	number = {5},
	journal = {Pharmacotherapy},
	author = {van Staa, T. P. and Leufkens, H. and Abenhaim, L. and Cooper, C.},
	month = oct,
	year = {1998},
	pmid = {9758324},
	keywords = {Aged, Cohort Studies, Etidronic Acid, Female, Great Britain, Humans, Male, Osteoporosis, Product Surveillance, Postmarketing, Quality Control, Retrospective Studies},
	pages = {1121--1128}
}

Paper  abstract   bibtex   

@article{bisceglia_littoral_1998,
	title = {Littoral cell angioma of the spleen: an additional report of four cases with emphasis on the association with visceral organ cancers},
	volume = {84},
	issn = {0300-8916},
	shorttitle = {Littoral cell angioma of the spleen},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/9862523},
	abstract = {AIMS AND BACKGROUND

Littoral cell angioma (LCA) is an uncommon vascular tumor of the spleen recently described and interpreted as the tumoral counterpart of the normally present littoral cells lining the splenic sinus channels of red pulp. The diagnosis of LCA is suggested by a quite characteristic morphology and confirmed by the demonstration of a hybrid endothelial/histiocytic phenotype.


METHODS

Four original and previously unreported cases of LCA are presented. All four splenic vascular tumors were investigated by light microscopy and immunohistochemistry for endothelial and histiocytic markers.


RESULTS

All four cases were associated with visceral epithelial malignancies (colorectal adenocarcinoma in two cases, renal and pancreatic adenocarcinoma in one case each). One case was also associated with an intracranial tentorial meningioma.


CONCLUSIONS

We consider our findings as a novelty and signal the possible existence of a clinical syndrome. Five of a total of 21 previously reported cases in the literature were also described as being associated with other cancers (non-Hodgkin's lymphoma in two cases, two not further specified tumors of the liver and brain, an epithelial ovarian cancer, and a non-small cell lung cancer in one case each). Close follow-up and careful investigation in search of a second visceral neoplasm are strongly recommended in cases of LCA, but further clinical observations and more in-depth genetic and molecular studies are needed before any valid conclusions can be drawn.},
	number = {5},
	urldate = {2012-03-26},
	journal = {Tumori},
	author = {Bisceglia, M and Sickel, J Z and Giangaspero, F and Gomes, V and Amini, M and Michal, M},
	month = oct,
	year = {1998},
	pmid = {9862523},
	keywords = {Aged, Brain Neoplasms, Colonic Neoplasms, Female, Hemangioma, Humans, Kidney Neoplasms, Male, Middle Aged, Neoplasms, Multiple Primary, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Splenic Neoplasms},
	pages = {595--599},
}

@article{murphy_audit_1998-1,
	title = {Audit of patients on oral anticoagulants with {International} normalized ratios of eight or above},
	volume = {20},
	issn = {0141-9854},
	abstract = {We reviewed retrospectively the medical records of all patients (n = 77, mean age 74.2) on oral anticoagulants with an International normalized ratio (INR) of eight or above in a 12-month period in the Leicestershire District Health Authority (DHA). From a total of 55,625 INRs, 131 (0.24\%) were {\textbackslash}textgreater or = 8. A major cause of over-anticoagulation was unsatisfactory dose loading during in-hospital commencement of oral anticoagulation. The incidence of major bleeding was 12.9\% of total episodes of INR {\textbackslash}textgreater or = 8 with two haemorrhage-related fatalities. Therapy of major haemorrhage with fresh frozen plasma (FFP) and intravenous (i.v) vitamin K proved effective but was not given in a majority of such cases. In conclusion, improvements in initial dose loading of oral anticoagulation and in the management of major haemorrhage are required. Severely over-anticoagulated patients without obvious bleeding should nevertheless receive small dose vitamin K therapy to reduce the risk of haemorrhage related morbidity and mortality without compromising subsequent oral anti-coagulant control.},
	language = {eng},
	number = {4},
	journal = {Clinical and Laboratory Haematology},
	author = {Murphy, P. T. and Casey, M. C. and Abrams, K. R.},
	month = aug,
	year = {1998},
	pmid = {9777273},
	keywords = {80 and over, Adult, Aged, Anticoagulants, Cardiovascular Diseases, Drug Interactions, Female, Heart Failure, Hemorrhage, Humans, International Normalized Ratio, Male, Medical Audit, Middle Aged, Retrospective Studies, Thrombosis, United Kingdom},
	pages = {253--257},
}

Website  abstract   bibtex   

@article{
 title = {Asthma on Tristan da Cunha: looking for the genetic link. The University of Toronto Genetics of Asthma Research Group},
 type = {article},
 year = {1996},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Age Distribution,Aged,Aged, 80 and over,Allergens/diagnostic use,Asthma/epidemiology/*genetics,Atlantic Ocean,Bronchoconstrictor Agents/diagnostic use,Child,Child, Preschool,Consanguinity,Female,Forced Expiratory Volume,Founder Effect,Humans,Linkage (Genetics),Male,Methacholine Chloride/diagnostic use,Middle Aged,Prevalence,Research Support, Non-U.S. Gov't,Sex Distribution,Skin Tests},
 pages = {1902-1906},
 volume = {153},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8665053},
 id = {ba377ad3-36ac-3937-b8d3-44f6b08c99e3},
 created = {2017-06-19T13:44:45.103Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:44:45.287Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>1073-449x<m:linebreak/>Journal Article</m:note>},
 abstract = {Although asthma has a significant heritable component, the mode of inheritance remains controversial because of the complexity of the disease and the influence of environmental factors. Isolated, inbred populations serve to reduce variability, thus increasing the probability of gene localization. We studied the inbred population of the remote island of Tristan da Cunha to document asthma prevalence for the purpose of genetic linkage analysis. Medical histories and skin atopy were determined on 282 islanders, representing 97% of the population, and airway responsiveness was measured in 254; 226 by methacholine challenge (tidal breathing method) and 28 by bronchodilator response (400 micrograms salbutamol aerosol). Blood samples were collected from 275 islanders. Participants ranged in age from 3 to 94 yr. Asthma was defined as increased airway responsiveness (AR+: PC20 < 4 mg/ml or > or = 15% increase in FEV1 postbronchodilator) combined with a positive history (Hx+). Fifty-seven percent of the islanders had at least partial evidence of asthma (Hx+ and/or AR+) and 23% had a definitive diagnosis of asthma (AR+ with Hx+). Overall 47% of the population were atopic, atopy was proportionally higher in asthmatics (74%) than nonasthmatics (32%; p < 0.01). Analysis of the methacholine dose-response curves demonstrated that asthmatics were significantly (p < 0.01) more responsive than those with AR+ only, and nonasthmatics (AR-, Hx-) were more responsive than laboratory control subjects (p < 0.05), suggesting that these islanders may also carry an airway hyperresponsiveness gene. A frequency plot of the percent fall in FEV1 for all Hx- subjects compared with control data suggests a bimodal distribution consistent with a major gene mechanism for airway responsiveness. Genealogy mapping revealed that the islanders are direct descendants of the 15 original settlers, and historical records suggest at least two founders may have been asthmatic. The data confirm previous reports of a high asthma prevalence on Tristan and support the postulate that this prevalence is a result of gene enrichment occurring in isolated populations by virtue of extensive inbreeding and a probable founder effect.},
 bibtype = {article},
 author = {Zamel, N and McClean, P A and Sandell, P R and Siminovitch, K A and Slutsky, A S},
 journal = {Am J Respir Crit Care Med},
 number = {6 Pt 1}
}

Paper  doi  abstract   bibtex   

@article{rao_relationship_1994,
	title = {The relationship between basal cell epithelioma and seborrheic keratosis. {A} study of 60 cases},
	volume = {20},
	copyright = {All rights reserved},
	issn = {0148-0812 (Print) 0148-0812 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/7962939},
	doi = {10.1111/j.1524-4725.1994.tb03201.x},
	abstract = {BACKGROUND: Various skin tumors can be seen rarely in association with seborrheic keratosis. We present 60 cases of seborrheic keratosis related to a basal cell epithelioma in the same specimen. OBJECTIVE: To report association of basal cell epithelioma with seborrheic keratosis and discuss the possibility of malignant change in seborrheic keratosis. METHODS: Sixty cases of seborrheic keratosis associated with basal cell epithelioma were studied. Tissues were fixed in neutral buffered formalin, processed, and stained with standard hematoxylin and eosin techniques. RESULTS: Histological evaluation showed a seborrheic keratosis associated with basal cell epithelioma in all of the cases. Basal cell epithelioma was attached with seborrheic keratosis in a majority of the cases (40/60) and appeared to represent a part of the same tumor. Both tumors were lying adjacent to each other in the rest of the cases (20/60). CONCLUSION: Malignant change in seborrheic keratosis is controversial. We recommend the histological evaluation of seborrheic keratosis especially when inflamed or atypical in appearance. This should not be taken as a mandate for pathological evaluation or for treatment of every seborrheic keratosis as though it was potentially malignant.},
	number = {11},
	journal = {J Dermatol Surg Oncol},
	author = {Rao, B. K. and Freeman, R. G. and Poulos, E. G. and Arbesfeld, L. and Rendon, M.},
	month = nov,
	year = {1994},
	keywords = {Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell/*complications/pathology, Cell Transformation, Neoplastic, Female, Humans, Keratosis, Seborrheic/*complications/pathology, Male, Middle Aged, Skin Neoplasms/*complications/pathology},
	pages = {761--4},
}

@Article{Farb_1990_1874,
  author = {Farb, A. and Virmani, R. and Atkinson, J. B. and Kolodgie, F. D.},
 journal = {J.Am.Coll.Cardiol.},
 note = {DA - 19901227 NOT IN FILE},
 number = {6},
 pages = {1421-1429},
 title = {Plaque morphology and pathologic changes in arteries from patients dying after coronary balloon angioplasty},
 volume = {16},
 year = {1990},
 keywords = {Aged, Angioplasty, Transluminal, Percutaneous, Coronary, Arteries, Autopsy, Coronary, Arteriosclerosis, Coronary, Vessels, Humans, Male, Middle, Aged, mortality, pathology, Retrospective, Studies, Survival, Analysis, therapy},
 title_with_no_special_chars = {Plaque morphology and pathologic changes in arteries from patients dying after coronary balloon angioplasty}
}

@Article{Phillips1985,
  author   = {DP Phillips and JR Mendelson and MS Cynader and RM Douglas},
  journal  = {Exp Brain Res},
  title    = {Responses of single neurones in cat auditory cortex to time-varying stimuli: {F}requency-modulated tones of narrow excursion.},
  year     = {1985},
  number   = {3},
  pages    = {443-54},
  volume   = {58},
  abstract = {In the primary auditory cortex of cats anaesthetized with nitrous
	oxide, single neurones were examined with respect to their responses
	to tone bursts and linear modulations of the frequency of an on-going
	continuous tone. Using FM ramps of 2.0 kHz excursion and varying
	centre frequency, each of 39 neurones was examined for its preference
	for the direction of frequency change of a ramp whose centre frequency
	was varied in and around the neurone's response area. Direction preference
	was strictly associated with the slopes of the cell's spike count-versus-frequency
	function over the frequency range covered by the ramp. Preferences
	for upward- and downward-directed ramps were associated with the
	low- and high-frequency slopes of the spike count function, respectively.
	The strength of the cell's direction preference was associated with
	the relative steepness of the spike count function over the frequency
	range covered by the ramp. The timing of discharges elicited by the
	frequency modulations was found to be the sum of the cell's latent
	period for tone bursts plus the time after ramp onset that the stimulus
	frequency fell within the neurone's response area. The implications
	of these data for the processing of narrow and broad frequency-modulated
	ramps are discussed.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, 4007088},
}

Paper  doi  abstract   bibtex   

@article{healton_subcortical_1982,
	title = {Subcortical neglect},
	volume = {32},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7201116},
	doi = {10/grrsst},
	abstract = {Unilateral neglect is usually caused by lesions of the right cerebral cortex, especially parietal. Neglect after subcortical lesions has been reported rarely in thalamic or striatal hemorrhage, and after infarction of thalamus or striatum and internal capsule shown by CT. In these patients, there may have been compression or ischemia of overlying cerebral cortex and white matter. We report a patient with sensory hemineglect, asomatognosia, and anosognosia caused by infarction of striatum and deep white matter, with involvement of neither cortex nor thalamus and without mass effect. This is the first autopsy-confirmed example of human neglect with involvement of only the striatum and deep white matter.},
	number = {7},
	journal = {Neurology},
	author = {Healton, E.B. and Navarro, C. and Bressman, S. and Brust, J.C.},
	year = {1982},
	keywords = {\#nosource, *Sensation, Aged, Brain/*pathology, Cerebral Infarction/*pathology, Corpus Striatum/pathology, Female, Humans, Laterality},
	pages = {776--778},
}

@article{franklin_sex_2009,
	title = {Sex differences in the association between body mass index and total hip or knee joint replacement resulting from osteoarthritis},
	volume = {68},
	issn = {1468-2060},
	doi = {10.1136/ard.2007.086868},
	abstract = {{OBJECTIVE}: To examine the association between body mass index ({BMI}) and osteoarthritis ({OA}) leading to total hip ({THR}) or knee ({TKR}) joint replacement.
{METHODS}: Case-control study design. All patients still living in Iceland who had had a {THR} or {TKR} resulting from {OA} before the end of 2002 were invited to participate. First-degree relatives of participating patients served as controls. A total of 1473 patients (872 women) and 1103 controls (599 women), all born between 1910 and 1939 and who had answered a questionnaire including questions about height and weight, were analysed. A randomly selected sample, representative of the Icelandic population, was used as a secondary control group.
{RESULTS}: The {OR}, adjusted for age, occupation and presence of hand {OA}, for having a {THR} was 1.1 (95\% {CI} 0.9 to 1.5) for overweight men and 1.7 (95\% {CI} 1.0 to 2.9) for obese men. The {OR} for having a {TKR} was 1.7 (95\% {CI} 1.1 to 2.6) for overweight men and 5.3 (95\% {CI} 2.8 to 10.1) for obese men. The {OR} for having a {THR} was 1.0 (95\% {CI} 0.8 to 1.3) for overweight women and 1.0 (95\% {CI} 0.6 to 1.5) for obese women. The {OR} for having a {TKR} was 1.6 (95\% {CI} 1.1 to 2.2) for overweight women and 4.0 (95\% {CI} 2.6 to 6.1) for obese women.
{CONCLUSION}: This study supports a positive association between high {BMI} and {TKR} in both sexes, but for {THR} the association with {BMI} seems to be weaker, and possibly negligible for women.},
	pages = {536--540},
	number = {4},
	journaltitle = {Annals of the Rheumatic Diseases},
	shortjournal = {Ann. Rheum. Dis.},
	author = {Franklin, J. and Ingvarsson, T. and Englund, M. and Lohmander, L. S.},
	date = {2009-04},
	pmid = {18504290},
	keywords = {Aged, 80 and over, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Body Mass Index, Case-Control Studies, Family, Female, Humans, Iceland, Male, Obesity, Occupational Diseases, Odds Ratio, Osteoarthritis, Hip, Osteoarthritis, Knee, Overweight, Regression Analysis, Risk Assessment, Sex Factors}
}