@article{fitzpatrick_report_2023, title = {Report of the {WHO} technical consultation on the evaluation of respiratory syncytial virus prevention cost effectiveness in low- and middle-income countries, {April} 7-8, 2022}, volume = {41}, issn = {1873-2518}, doi = {10.1016/j.vaccine.2023.09.040}, abstract = {Policymakers often rely on impact and cost-effectiveness evaluations to inform decisions about the introduction of health interventions in low- and middle-income countries (LMICs); however, cost-effectiveness results for the same health intervention can differ by the choice of parameter inputs, modelling assumptions, and geography. Anticipating the near-term availability of new respiratory syncytial virus (RSV) prevention products, WHO convened a two-day virtual consultation in April 2022 with stakeholder groups and global experts in health economics, epidemiology, and vaccine implementation. The objective was to review methods, parameterization, and results of existing cost-effectiveness analyses for RSV prevention in LMICs; identify the most influential inputs and data limitations; and recommend and prioritize future data gathering and research to improve RSV prevention impact estimates in LMICs. Epidemiological parameters identified as both influential and uncertain were those associated with RSV hospitalization and death, specifically setting-specific hospitalization rates and RSV-attributable death rates. Influential economic parameters included product price, delivery costs, willingness-to-pay for health on the part of potential donors, and the cost of RSV-associated hospitalization. Some of the influential parameters identified at this meeting should be more precisely measured by further research. Other influential economic parameters that are highly uncertain may not be resolved, and it is appropriate to use sensitivity analyses to explore these within cost-effectiveness evaluations. This report highlights the presentations and major discussions of the meeting.}, language = {eng}, number = {48}, journal = {Vaccine}, author = {Fitzpatrick, Meagan C. and Laufer, Rachel S. and Baral, Ranju and Driscoll, Amanda J. and Feikin, Daniel R. and Fleming, Jessica A. and Jit, Mark and Kim, Sonnie and Koltai, Mihaly and Li, You and Li, Xiao and Nair, Harish and Neuzil, Kathleen M. and Pecenka, Clint and Sparrow, Erin and Srikantiah, Padmini and Ortiz, Justin R.}, month = nov, year = {2023}, pmid = {37777450}, pmcid = {PMC10680976}, keywords = {Humans, Infant, Respiratory Syncytial Virus Infections, Developing Countries, Cost-Effectiveness Analysis, Respiratory Syncytial Virus, Human, Cost-Benefit Analysis, Referral and Consultation, Hospitalization, World Health Organization, Cost effectiveness, Global health, Monoclonal antibody, Respiratory syncytial virus, Vaccine}, pages = {7047--7059}, }
@article{kissani_epilepsy_2021, title = {Epilepsy surgery in {Africa}: state of the art and challenges}, volume = {118}, issn = {15255050}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102646411&doi=10.1016%2fj.yebeh.2021.107910&partnerID=40&md5=2de0aadc0987fd3b901d76443e76b71d}, doi = {10.1016/j.yebeh.2021.107910}, language = {English}, journal = {Epilepsy and Behavior}, author = {Kissani, N. and Nafia, S. and El Khiat, A. and Bengamara, N. and Maiga, Y. and Sogoba, Y. and Ahmed A. Ibrahim, E. and Agbetou, M. and Massi Daniel, G. and Assogba, K. and Matar Gaye, N. and Kuate Tegueu, C. and Hussein Ragab, A. and Razafimahefa, J. and Wilmshurst, J. and Naidoo, A. and Jabang, J.N. and Watila, M.}, year = {2021}, note = {Publisher: Academic Press Inc.}, keywords = {Africa, Algeria, Article, Egypt, Electroencephalography, Epilepsy, Humans, Kenya, Morocco, Poverty, South Africa, Surveys and Questionnaires, Tunisia, Uganda, brain surgery, computer assisted tomography, e-mail, electroencephalography, electroencephalography monitoring, epilepsy, epileptologist, health care access, health care availability, health care cost, health care utilization, human, neurologist, nuclear magnetic resonance imaging, poverty, preoperative evaluation, questionnaire, single photon emission computed tomography}, }
@article{krohn_global_2021, title = {Global {Health} {Education} during the {COVID}-19 {Pandemic}: {Challenges}, {Adaptations}, and {Lessons} {Learned}}, volume = {105}, issn = {0002-9637}, shorttitle = {Perspective piece global health education during the {COVID}-19 pandemic}, doi = {10/gpgn7n}, abstract = {Global health education programs should strive continually to improve the quality of education, increase access, create communities that foster excellence in global health practices, and ensure sustainability. The COVID-19 pandemic forced the University of Minnesota's extensive global health education programs, which includes a decade of hybrid online and in-person programing, to move completely online. We share our experience, a working framework for evaluating global health educational programming, and lessons learned. Over the decades we have moved from a predominantly passive, lecture-based, in-person course to a hybrid online (passive) course with an intensive hands-on 2-week requirement. The pandemic forced us to explore new active online learning models. We retained our on-demand, online passive didactics, which used experts' time efficiently and was widely accessible and well received. In addition, we developed a highly effective synchronous online component that we felt replaced some of the hands-on activities effectively and led us to develop new and innovative “hands-on” experiences. This new, fully online model combining quality asynchronous and synchronous learning provided many unanticipated advantages, such as increasing access while decreasing our carbon footprint dramatically. By sharing our experience, lessons learned, and resources, we hope to inspire other programs likewise to innovate to improve quality, access, community, and sustainability in global health, especially if these innovations can help decrease negative aspects of global health education such as its environmental impact. Copyright © 2021 by The American Society of Tropical Medicine and Hygiene}, language = {English}, number = {6}, journal = {The American Journal of Tropical Medicine and Hygiene}, author = {Krohn, K.M. and Sundberg, M.A. and Quadri, N.S. and Stauffer, W.M. and Dhawan, A. and Pogemiller, H. and Leuche, V.T. and Kesler, S. and Gebreslasse, T.H. and Shaughnessy, M.K. and Pritt, B. and Habib, A. and Scudder, B. and Sponsler, S. and Dunlop, S. and Hendel-Paterson, B.}, year = {2021}, keywords = {Article, COVID-19, Curriculum, Education, Distance, Global Health, Health Education, Humans, SARS-CoV-2, Thailand, Uganda, United States, Universities, adaptation, carbon footprint, community, coronavirus disease 2019, curriculum, education, environmental impact, epidemiology, global health, health care access, health care quality, health education, health program, human, learning, online system, pandemic, university}, pages = {1463--1467}, }
@article{degenhardt_perceived_2021, title = {Perceived helpfulness of treatment for alcohol use disorders: {Findings} from the {World} {Mental} {Health} {Surveys}}, volume = {229}, issn = {03768716}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120963570&doi=10.1016%2fj.drugalcdep.2021.109158&partnerID=40&md5=134711ac79b2bfbba08a90b62df24d71}, doi = {10.1016/j.drugalcdep.2021.109158}, language = {English}, journal = {Drug and Alcohol Dependence}, author = {Degenhardt, L. and Bharat, C. and Chiu, W.T. and Sampson, N.A. and Kessler, R.C. and Kazdin, A.E. and Harris, M.G. and Harris, M.G. and McGrath, J.J. and Vigo, D.V. and Vigo, D.V. and Alonso, J. and Alonso, J. and Alonso, J. and Andrade, L.H. and Bruffaerts, R. and Bunting, B. and Cardoso, G. and de Girolamo, G. and Florescu, S. and Gureje, O. and Makanjuola, V. and Haro, J.M. and Hu, C. and Karam, A.N. and Karam, E.G. and Karam, E.G. and Karam, E.G. and Kovess-Masfety, V. and Lee, S. and McGrath, J.J. and McGrath, J.J. and Medina-Mora, M.E. and Moskalewicz, J. and Navarro-Mateu, F. and Navarro-Mateu, F. and Navarro-Mateu, F. and Posada-Villa, J. and Rapsey, C. and Stagnaro, J.C. and Tachimori, H. and ten Have, M. and Torres, Y. and Williams, D.R. and Zarkov, Z. and Al-Hamzawi, A. and Al-Kaisy, M.S. and Alonso, J. and Altwaijri, Y.A. and Andrade, L.H. and Atwoli, L. and Benjet, C. and Borges, G. and Bromet, E.J. and Bruffaerts, R. and Bunting, B. and Caldas-de-Almeida, J.M. and Cardoso, G. and Chatterji, S. and Cia, A.H. and Degenhardt, L. and Demyttenaere, K. and Florescu, S. and Girolamo, Giovanni de and Gureje, O. and Haro, J.M. and Harris, M.G. and Hinkov, H. and Hu, C.-Y. and Jonge, Peter de and Karam, A.N. and Karam, E.G. and Karam, G. and Kawakami, N. and Kessler, R.C. and Kiejna, A. and Kovess-Masfety, V. and Lee, S. and Lepine, J.-P. and McGrath, J.J. and Medina-Mora, M.E. and Mneimneh, Z. and Moskalewicz, J. and Navarro-Mateu, F. and Piazza, M. and Posada-Villa, J. and Scott, K.M. and Slade, T. and Stagnaro, J.C. and Stein, D.J. and Have, Margreet ten and Torres, Y. and Viana, M.C. and Vigo, D.V. and Whiteford, H. and Williams, D.R. and Wojtyniak, B.}, year = {2021}, note = {Publisher: Elsevier Ireland Ltd}, keywords = {Article, adult, aged, alcoholism, alternative medicine, controlled study, cooperation, drug abuse, female, help seeking behavior, high income country, human, low income country, male, middle income country, prevalence, probability, psychotherapy, treatment failure}, }
@article{filimonau_carbon_2021, title = {The carbon footprint of a {UK} {University} during the {COVID}-19 lockdown}, volume = {756}, issn = {0048-9697}, url = {https://www.sciencedirect.com/science/article/pii/S0048969720374957}, doi = {10/ghqb5t}, abstract = {The COVID-19 pandemic has provided a unique opportunity to compare the carbon intensity of higher education delivered on- and off-campus. This is attributed to governmental lockdown orders that have forced Universities to close their campuses, ban business travel and move all teaching and learning activities online. This study represents the first known attempt to compare the carbon footprint of a mid-sized UK University produced during the COVID-19 lockdown (April–June 2020) against that generated within the respective time period in previous years. Although the overall carbon footprint of the University decreased by almost 30\% during the lockdown, the carbon intensity of online teaching and learning was found to be substantial and almost equal to that of staff and student commute in the pre-lockdown period. The study contributed to an emerging academic discourse on the carbon (dis)benefits of different models of higher education provision in the UK and beyond. The study suggested that policy and management decisions on transferring education online should carefully consider the carbon implications of this transfer.}, language = {en}, urldate = {2022-03-15}, journal = {Science of The Total Environment}, author = {Filimonau, Viachaslau and Archer, Dave and Bellamy, Laura and Smith, Neil and Wintrip, Richard}, month = feb, year = {2021}, keywords = {Academic discourse, Article, Business travel, COVID-19, Carbon Footprint, Carbon footprint, Carbon intensity, Communicable Disease Control, E-learning, Education computing, Emission control, GHG emissions, Higher education, Humans, Management decisions, Online teaching, Online teaching and learning, Pandemic, Pandemics, Previous year, SARS-CoV-2, Sustainable development, Teaching, Teaching and learning, Tourism industry, United Kingdom, Universities, carbon, carbon footprint, communicable disease control, controlled study, coronavirus disease 2019, e-learning, environmental policy, greenhouse gas, higher education, human, pandemic, priority journal, quarantine, sustainable development, teaching, university, university student, viral disease}, pages = {143964}, }
@article{vinogradova_activity-guided_2020, title = {An {Activity}-{Guided} {Map} of {Electrophile}-{Cysteine} {Interactions} in {Primary} {Human} {T} {Cells}}, volume = {182}, issn = {0092-8674, 1097-4172}, url = {https://www.cell.com/cell/abstract/S0092-8674(20)30823-0}, doi = {10.1016/j.cell.2020.07.001}, language = {English}, number = {4}, urldate = {2022-08-18}, journal = {Cell}, author = {Vinogradova, Ekaterina V. and Zhang, Xiaoyu and Remillard, David and Lazar, Daniel C. and Suciu, Radu M. and Wang, Yujia and Bianco, Giulia and Yamashita, Yu and Crowley, Vincent M. and Schafroth, Michael A. and Yokoyama, Minoru and Konrad, David B. and Lum, Kenneth M. and Simon, Gabriel M. and Kemper, Esther K. and Lazear, Michael R. and Yin, Sifei and Blewett, Megan M. and Dix, Melissa M. and Nguyen, Nhan and Shokhirev, Maxim N. and Chin, Emily N. and Lairson, Luke L. and Melillo, Bruno and Schreiber, Stuart L. and Forli, Stefano and Teijaro, John R. and Cravatt, Benjamin F.}, month = aug, year = {2020}, pmid = {32730809}, note = {Publisher: Elsevier}, keywords = {BIRC3, ITK, T cells, activity-based protein profiling, chemical proteomics, covalent, cysteine, electrophiles, human, protein degradation}, pages = {1009--1026.e29}, }
@article{jansen_burden_2020, title = {Burden of {Illness} and {Quality} of {Life} in {Tuberous} {Sclerosis} {Complex}: {Findings} {From} the {TOSCA} {Study}}, volume = {11}, issn = {16642295}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090896990&doi=10.3389%2ffneur.2020.00904&partnerID=40&md5=1faa143e97a93bf95e1228ed0c704c24}, doi = {10.3389/fneur.2020.00904}, language = {English}, journal = {Frontiers in Neurology}, author = {Jansen, A.C. and Vanclooster, S. and de Vries, P.J. and Fladrowski, C. and Beaure d'Augères, G. and Carter, T. and Belousova, E. and Benedik, M.P. and Cottin, V. and Curatolo, P. and Dahlin, M. and D'Amato, L. and Ferreira, J.C. and Feucht, M. and Hertzberg, C. and Jozwiak, S. and Lawson, J.A. and Macaya, A. and Marques, R. and Nabbout, R. and O'Callaghan, F. and Qin, J. and Sander, V. and Sauter, M. and Shah, S. and Takahashi, Y. and Touraine, R. and Youroukos, S. and Zonnenberg, B. and Kingswood, J.C. and Shinohara, N. and Horie, S. and Kubota, M. and Tohyama, J. and Imai, K. and Kaneda, M. and Kaneko, H. and Uchida, Y. and Kirino, T. and Endo, S. and Inoue, Y. and Uruno, K. and Serdaroglu, A. and Yapici, Z. and Anlar, B. and Altunbasak, S. and Lvova, O. and Belyaev, O.V.B. and Agranovich, O. and Levitina, E.V.L. and Maksimova, Y.V.M. and Karas, A. and Jiang, Y. and Zou, L. and Xu, K. and Zhang, Y. and Luan, G. and Zhang, Y. and Wang, Y. and Jin, M. and Ye, D. and Ye, D. and Zhou, L. and Liu, J. and Liao, J. and YAN, B. and Deng, Y. and Jiang, L. and Liu, Z. and Huang, S. and Li, H. and Kim, K. and Chen, P.-L. and Lee, H.-F. and Tsai, J.-D. and Chi, C.-S. and Huang, C.-C. and Riney, K. and Yates, D. and Kwan, P. and Likasitwattanakul, S. and Nabangchang, C. and Chomtho, L.T.K. and Katanyuwong, K. and Sriudomkajorn, S. and Wilmshurst, J. and Segel, R. and Gilboa, T. and Tzadok, M. and Fattal-Valevski, T. and Papathanasopoulos, P. and Papavasiliou, A.S.P. and Giannakodimos, S. and Gatzonis, S. and Pavlou, E. and Tzoufi, M. and Vergeer, A.M.H. and Dhooghe, M. and Verhelst, H. and Roelens, F. and Nassogne, M.C.N. and Defresne, P. and Waele, L.D.W. and Leroy, P. and Demonceau, N. and Legros, B. and Bogaert, P.V.B. and Ceulemans, B. and Dom, L. and Castelnau, P. and Martin, A.D.S. and Riquet, A. and Milh, M. and Cances, C. and Pedespan, J.-M. and Ville, D. and Roubertie, A. and Auvin, S. and Berquin, P. and Richelme, C. and Allaire, C. and Gueden, S. and Tich, S.N.T. and Godet, B. and da Silva Oliveira Monteiro, J.P. and de Oliveira Ferreira Leao, M.J.S. and Planas, J.C.P. and Bermejo, A.M.B. and Dura, P.S.D. and Aparicio, S.R.A. and Gonzalez, M.J.M. and Pison, J.L.P. and Barca, M.O.B. and Laso, E.L.L. and Luengo, O.A.L. and Rodriguez, F.J.A. and Dieguez, I.M.D. and Salas, A.C.S. and Carrera, I.M.C. and Salcedo, E.M.S. and Petri, M.E.Y. and Candela, R.C.C. and da Conceicao Carrilho, I. and Vieira, J.P.V. and da Silva Oliveira Monteiro, J.P. and de Oliveira Ferreira Leao, M.J.S. and Luis, C.S.M.R. and Mendonca, C.P.M. and Endziniene, M. and Strautmanis, J. and Talvik, I. and Canevini, M.P.C. and Gambardella, A. and Pruna, D. and Buono, S. and Fontana, E. and Bernardina, B.D.B. and Burloiu, C. and Cosma, I.S.B. and Vintan, M.A.V. and Popescu, L. and Zitterbart, K. and Payerova, J. and Bratsky, L. and Zilinska, Z. and Sedlmayr, U.G. and Baumann, M. and Haberlandt, E. and Rostasy, K. and Pataraia, E. and Elmslie, F. and Johnston, C.A.J. and Crawford, P. and Uldall, P. and Uvebrant, P. and Rask, O. and Bjoernvold, M. and Brodtkorb, E. and Sloerdahl, A. and Solhoff, R. and Jaatun, M.S.G. and Mandera, M. and Radzikowska, E.J.R. and Wysocki, M. and Fischereder, M. and Kurlemann, G. and Wilken, B. and K-ruel, A.W.K. and Budde, K. and Marquard, K. and Knuf, M. and Hahn, A. and Hartmann, H. and Merkenschlager, A. and Trollmann, R. and Investigators, TOSCA Consortium TOSCA}, year = {2020}, note = {Publisher: Frontiers Media S.A.}, keywords = {Article, adolescent, adult, aged, career, caregiver, child, disease burden, educational status, employment, family life, female, human, informed consent, major clinical study, male, patient care, personal experience, psychological well-being, quality of life, questionnaire, social psychology, social support, tuberous sclerosis, unemployment, validation process}, }
@article{brakoulias_rates_2020, title = {The rates of co-occurring behavioural addictions in treatment-seeking individuals with obsessive-compulsive disorder: a preliminary report}, volume = {24}, issn = {13651501}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078016820&doi=10.1080%2f13651501.2019.1711424&partnerID=40&md5=f7662be6edcfacc238a638b465092af8}, doi = {10.1080/13651501.2019.1711424}, language = {English}, number = {2}, journal = {International Journal of Psychiatry in Clinical Practice}, author = {Brakoulias, V. and Starcevic, V. and Albert, U. and Arumugham, S.S. and Bailey, B.E. and Belloch, A. and Borda, T. and Dell’Osso, L. and Elias, J.A. and Falkenstein, M.J. and Ferrao, Y.A. and Fontenelle, L.F. and Jelinek, L. and Kay, B. and Lochner, C. and Maina, G. and Marazziti, D. and Matsunaga, H. and Miguel, E.C. and Morgado, P. and Pasquini, M. and Perez-Rivera, R. and Potluri, S. and Reddy, J.Y.C. and Riemann, B.C. and do Rosario, M.C. and Shavitt, R.G. and Stein, D.J. and Viswasam, K. and Fineberg, N.A.}, year = {2020}, note = {Publisher: Taylor and Francis Ltd}, keywords = {Addictive, Adolescent, Adult, Argentina, Article, Australia, Behavior, Brazil, Comorbidity, Female, Gambling, Germany, Humans, India, Internet, Internet Addiction Disorder, Italy, Japan, Male, Mexico, Middle Aged, Obsessive-Compulsive Disorder, Portugal, Sexual Behavior, South Africa, Spain, United Kingdom, United States, Video Games, Young Adult, addiction, adolescent, adult, behavioral addiction, clinical trial, comorbidity, compulsive buying, female, gambling, game addiction, help seeking behavior, human, internet addiction, major clinical study, male, middle aged, multicenter study, obsessive compulsive disorder, pathological gambling, priority journal, sexual behavior, video game, young adult}, pages = {173--175}, }
@article{lourens_acute_2020, title = {Acute pain assessment and management in the prehospital setting, in the {Western} {Cape}, {South} {Africa}: {A} knowledge, attitudes and practices survey}, volume = {20}, issn = {1471227X}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084107654&doi=10.1186%2fs12873-020-00315-0&partnerID=40&md5=6a9e1ed0ddf7e6a805a5a2f423b829e2}, doi = {10.1186/s12873-020-00315-0}, language = {English}, number = {1}, journal = {BMC Emergency Medicine}, author = {Lourens, A. and Hodkinson, P. and Parker, R.}, year = {2020}, note = {Publisher: BioMed Central Ltd.}, keywords = {Acute Pain, Adult, Article, Attitudes, Cross-Sectional Studies, Emergency Medical Technicians, Female, Health Knowledge, Humans, Internet, Male, Pain Measurement, Practice, Professional Competence, South Africa, Surveys and Questionnaires, adult, age, alcohol consumption, analgesia, analgesic agent, attitude, attitude to health, case study, clinical practice, controlled study, cross-sectional study, descriptive research, drug dependence, emergency care, female, gender, government, health personnel attitude, human, job experience, ketamine, male, medical education, middle aged, morphine, nitrous oxide plus oxygen, pain, pain assessment, pain measurement, patient-reported outcome, professional competence, questionnaire, rescue personnel, scoring system, validation study, young adult}, }
@article{dalvie_genomic_2020, title = {Genomic influences on self-reported childhood maltreatment}, volume = {10}, issn = {21583188}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079648385&doi=10.1038%2fs41398-020-0706-0&partnerID=40&md5=5c976b992182fd4f1c7a5d71edaccc98}, doi = {10.1038/s41398-020-0706-0}, language = {English}, number = {1}, journal = {Translational Psychiatry}, author = {Dalvie, S. and Maihofer, A.X. and Coleman, J.R.I. and Bradley, B. and Breen, G. and Brick, L.A. and Chen, C.-Y. and Choi, K.W. and Duncan, L.E. and Guffanti, G. and Haas, M. and Harnal, S. and Liberzon, I. and Nugent, N.R. and Provost, A.C. and Ressler, K.J. and Torres, K. and Amstadter, A.B. and Bryn Austin, S. and Baker, D.G. and Bolger, E.A. and Bryant, R.A. and Calabrese, J.R. and Delahanty, D.L. and Farrer, L.A. and Feeny, N.C. and Flory, J.D. and Forbes, D. and Galea, S. and Gautam, A. and Gelernter, J. and Hammamieh, R. and Jett, M. and Junglen, A.G. and Kaufman, M.L. and Kessler, R.C. and Khan, A. and Kranzler, H.R. and Lebois, L.A.M. and Marmar, C. and Mavissakalian, M.R. and McFarlane, A. and Donnell, M.O. and Orcutt, H.K. and Pietrzak, R.H. and Risbrough, V.B. and Roberts, A.L. and Rothbaum, A.O. and Roy-Byrne, P. and Ruggiero, K. and Seligowski, A.V. and Sheerin, C.M. and Silove, D. and Smoller, J.W. and Stein, M.B. and Teicher, M.H. and Ursano, R.J. and Van Hooff, M. and Winternitz, S. and Wolff, J.D. and Yehuda, R. and Zhao, H. and Zoellner, L.A. and Stein, D.J. and Koenen, K.C. and Nievergelt, C.M.}, year = {2020}, note = {Publisher: Springer Nature}, keywords = {Article, Child, Child Abuse, FOXP1 protein, Forkhead Transcription Factors, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Humans, Post-Traumatic, Repressor Proteins, Self Report, Stress Disorders, child, child abuse, depression, forkhead transcription factor, gene linkage disequilibrium, genetic correlation, genetic predisposition, genetic risk score, genetic variation, genome-wide association study, genomics, genotype, health status, heritability, human, mental health, molecular phylogeny, phenotype, posttraumatic stress disorder, repressor protein, self report, single nucleotide polymorphism}, }
@article{scott_intermittent_2020, title = {Intermittent explosive disorder subtypes in the general population: {Association} with comorbidity, impairment and suicidality}, issn = {20457960}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087734639&doi=10.1017%2fS2045796020000517&partnerID=40&md5=399528f230db3e40bed4b45d0ca11be3}, doi = {10.1017/S2045796020000517}, language = {English}, journal = {Epidemiology and Psychiatric Sciences}, author = {Scott, K.M. and De Vries, Y.A. and Aguilar-Gaxiola, S. and Al-Hamzawi, A. and Alonso, J. and Bromet, E.J. and Bunting, B. and Caldas-De-Almeida, J.M. and Ciá, A. and Florescu, S. and Gureje, O. and Hu, C.-Y. and Karam, E.G. and Karam, A. and Kawakami, N. and Kessler, R.C. and Lee, S. and McGrath, J. and Oladeji, B. and Posada-Villa, J. and Stein, D.J. and Zarkov, Z. and De Jonge, P.}, year = {2020}, note = {Publisher: Cambridge University Press}, keywords = {Adult, Anger, Comorbidity, Disruptive, Female, Health Surveys, Humans, Impulse Control, Impulsive Behavior, Male, Mental Disorders, Severity of Illness Index, Suicidal Ideation, Suicide, Violence, adult, and Conduct Disorders, anger, comorbidity, female, health survey, human, impulse control disorder, impulsiveness, male, mental disease, psychology, severity of illness index, suicidal ideation, suicide, violence}, }
@article{bhuyan_responding_2018, title = {Responding to the {Structural} {Violence} of {Migrant} {Domestic} {Work}: {Insights} from {Participatory} {Action} {Research} with {Migrant} {Caregivers} in {Canada}}, volume = {33}, issn = {08857482}, url = {https://search.proquest.com/docview/2087791145?accountid=12507}, doi = {10.1007/s10896-018-9988-x}, abstract = {This study explores international domestic workers’ response to employer abuse and exploitation following changes to Canada’s Live-in-Caregiver Program in 2014. This research followed an interpretive policy analysis research design, using feminist, participatory, and action research methods. University-based researchers, advocates, and peer researchers collaborated to develop and implement the project’s research and advocacy goals. Thirty-one caregivers in Toronto and Calgary participated in individual and/or focus group interviews to discuss access to permanent residence, working conditions and forms of support. Many shared examples of labor exploitation and psychological hardship due to precarious work conditions and long periods of family separation. Barriers to accessing services and fear of losing status led the majority of caregivers to rely primarily on informal networks for mutual aid and support. This paper identifies how changes in Canada’s temporary foreign worker program for live-in-caregivers exacerbates the structural violence of migrant care work, where the risk for abuse, exploitation, and risk of losing status is normalized. Migrant caregivers accept the precarious work conditions with the promise of permanent residence and the chance to improve their lives for themselves and their children. Towards envisioning improvements in social service delivery, our research highlighted the need for social services to increase outreach and safety planning for migrant workers who are vulnerable to abuse, exploitation, and the loss of legal immigration status. Our research also supports grassroots advocacy to call for all migrant workers to be granted permanent resident status upon arrival to ameliorate the structural violence of migrant labor.}, language = {English}, number = {8}, journal = {Journal of Family Violence}, author = {Bhuyan, Rupaleem and Valmadrid, Lorraine and {Esel Laxa Panlaqui} and Pendon, Novabella L and {Pearlita Juan}}, month = nov, year = {2018}, note = {Place: New York Publisher: Springer Nature B.V.}, keywords = {Abuse, Action Research, Action research, Advocacy services, Canada, Caregivers, Caregivers -- Psychosocial Factors, Children, Criminology And Law Enforcement, Delivery systems, Domestic labour, Domestic violence, Domestic workers, Exploitation, Fear \& phobias, Focus Groups, Focus group interviews, Human, Human Migration, Human Trafficking, Human trafficking, Immigrants -- Canada, Immigration, Immigration policy, Interviews, Labor, Migrant, Migrant workers, Outreach programmes, Participatory action research, Policy analysis, Precarious immigration, Research design, Research methodology, Researchers, Residence, Safety, Service delivery, Social networks, Social research, Social services, Violence, Violence against women, Vulnerability, Work environment, Working Conditions, Working conditions, Workplace Violence, caregivers, employer abuse, employer exploitation, migrant domestic work, participatory action research, permanent residence, policy analysis, structural violence, working conditions}, pages = {613--627}, }
@article{meneses_fernandez_using_2017, title = {Using communication and visualization technologies with senior citizens to facilitate cultural access and self-improvement}, volume = {66}, issn = {07475632}, url = {https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84991489830&doi=10.1016%2fj.chb.2016.10.001&partnerID=40&md5=28ad769cb901aea58030895ba49715d2}, doi = {10.1016/j.chb.2016.10.001}, abstract = {This paper presents the results of research that explores the social impacts and benefits of using digital visualization technologies, which include Augmented Reality (AR), Virtual Reality (VR) and Quick Response codes (QR codes). The target group for this study was senior citizens in an adult day care centre. This group was selected for two reasons: firstly, for belonging to a generation that has not grown up surrounded by digital technologies; and secondly, for therefore being at a disadvantage when it comes to adopting and using modern day information and communication technologies. Research was focused on the potential benefits of digital technologies and also on how senior citizens responded towards them, in particular how they felt these technologies were improving their social and personal well-being. Digital technologies were introduced into the day-to-day lives of senior citizens, providing them with a variety of alternative ways to access social media, communication tools or cultural content. Using digital technologies, they were also asked to perform activities related to their own personal and social well-being. © 2016 Elsevier Ltd}, language = {English}, journal = {Computers in Human Behavior}, author = {Meneses Fernández, M.D. and Santana Hernández, J.D. and Martín Gutiérrez, J. and Henríquez Escuela, M.R. and Rodríguez Fino, E.}, year = {2017}, keywords = {Augmented reality, Communication tools, Digital technologies, Digital visualization, Economic and social effects, Information and Communication Technologies, Mass media, Senior citizens, Social well-being, Virtual reality, Visualization, Visualization technologies, adult, adult day care, human, human experiment, mass medium, social media, virtual reality, wellbeing}, pages = {329--344} }
@misc{baker_s.c._systematic_2017, title = {Systematic {Review} of {Interventions} to {Reduce} {Psychiatric} {Morbidity} in {Parents} and {Children} {After} {PICU} {Admissions}}, url = {http://journals.lww.com/pccmjournal}, abstract = {OBJECTIVE:: To describe and evaluate interventions aimed at reducing psychiatric morbidity in parents and children discharged from PICU. DATA SOURCES:: A systematic review of the literature was undertaken, searching EMBASE, PSYCHinfo, MEDLINE, and CINAHL. Experts in the field were contacted to identify unpublished studies. STUDY SELECTION:: Exclusion criteria: Studies with participants above age 18 or drawn from a neonatal ICU, studies not in English, and those not measuring psychopathology. DATA EXTRACTION:: Seven hundred fifty-three articles initially identified were hand searched which identified three studies, with a further three studies found by contacting experts in the field. Of these, three were randomized controlled trials and three feasibility studies. DATA SYNTHESIS:: The interventions primarily targeted parents (particularly mothers), with the aim of reducing psychopathology especially posttraumatic stress disorder. Findings from these few studies demonstrated that interventions can lead to a reduction in parent and child psychopathology. Key ingredients of these interventions included psychoeducation, parent support after discharge, offering intervention to those families at high risk of developing psychopathology as identified by screening at the point of discharge, follow-up of all families with the aim of case finding, and specific interventions to target posttraumatic stress disorder symptoms. CONCLUSIONS:: Intervention studies are few but do lead to reductions in parent and child psychopathology. There is sufficient information to suggest some of these interventions could be supported and further evaluated. Copyright ©2017The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies}, journal = {Pediatric Critical Care Medicine}, author = {{Baker S.C.} and {Gledhill J.A.}}, year = {2017}, keywords = {*morbidity, *psychiatric intensive care unit, Child, Cinahl, Embase, Medline, Neonatal intensive care unit, PsycINFO, adult, case finding, controlled study, family study, feasibility study, female, follow up, human, intervention study, mental disease, mother, newborn, posttraumatic stress disorder, psychoeducation, screening, systematic review, young adult} }
@misc{dencker_a._midwife-led_2017, title = {Midwife-led maternity care in {Ireland} - a retrospective cohort study}, url = {http://www.biomedcentral.com/bmcpregnancychildbirth/}, abstract = {Background: Midwife-led maternity care is shown to be safe for women with low-risk during pregnancy. In Ireland, two midwife-led units (MLUs) were introduced in 2004 when a randomised controlled trial (the MidU study) was performed to compare MLU care with consultant-led care (CLU). Following study completion the two MLUs have remained as a maternity care option in Ireland. The aim of this study was to evaluate maternal and neonatal outcomes and transfer rates during six years in the larger of the MLU sites. Methods: MLU data for the six years 2008-2013 were retrospectively analysed, following ethical approval. Rates of transfer, reasons for transfer, mode of birth, and maternal and fetal outcomes were assessed. Linear-by-Linear Association trend analysis was used for categorical data to evaluate trends over the years and one-way ANOVA was used when comparing continuous variables. Results: During the study period, 3,884 women were registered at the MLU. The antenatal transfer rate was 37.4\% and 2,410 women came to labour in the MLU. Throughout labour and birth, 567 women (14.6\%) transferred to the CLU, of which 23 were transferred after birth due to need for suturing or postpartum hemorrhage. The most common reasons for intrapartum transfer were meconium stained liquor/abnormal fetal heart rate (30.3\%), delayed labour progress in first or second stage (24.9\%) and woman's wish for epidural analgesia (15.1\%). Of the 1,903 babies born in the MLU, 1,878 (98.7\%) were spontaneous vaginal births and 25 (1.3\%) were instrumental (ventouse/forceps). Only 25 babies (1.3\%) were admitted to neonatal intensive care unit. All spontaneous vaginal births from the MLU registered population, occurring in the study period in both the MLU and CLU settings (n = 2,785), were compared. In the MLU more often 1-2 midwives (90.9\% vs 69.7\%) cared for the women during birth, more women had three vaginal examinations or fewer (93.6\% vs 79.9\%) and gave birth in an upright position (standing, squatting or kneeling) (52.0\% vs 9.4\%), fewer women had an amniotomy (5.9\% vs 25.9\%) or episiotomy (3.4\% vs 9.7\%) and more women had a physiological management of third stage of labour (50.9\% vs 4.6\%). Conclusions: Midwife-led care is a safe option that could be offered to a large proportion of healthy pregnant women. With strict transfer criteria there are very few complications during labour and birth. Maternity units without the option of MLU care should consider its introduction. Copyright © 2017 The Author(s).}, journal = {BMC Pregnancy and Childbirth}, author = {{Dencker A.} and {Smith V.} and {McCann C.} and {Begley C.}}, year = {2017}, keywords = {*Ireland, *cohort analysis, *high risk pregnancy, *labor stage 3, *maternal care, *midwife, Neonatal intensive care unit, amniotomy, analysis of variance, consultation, controlled clinical trial, controlled study, epidural analgesia, episiotomy, female, fetus, fetus heart rate, fetus outcome, forceps, human, human tissue, liquid, major clinical study, male, meconium, newborn, pelvic examination, postpartum hemorrhage, pregnant woman, randomized controlled trial, standing, statistical model, vaginal delivery} }
@misc{kim_e.s._teduglutide:_2017, title = {Teduglutide: {A} {Review} in {Short} {Bowel} {Syndrome}}, url = {http://rd.springer.com/journal/40265}, abstract = {Subcutaneous teduglutide (Revestive), a glucagon-like peptide-2 analogue that increases intestinal absorption, is approved in the EU for the treatment of short bowel syndrome (SBS) in patients aged {\textgreater}1 year who are stable following a period of postsurgical intestinal adaptation. In a phase III trial in adults with SBS intestinal failure (IF) dependent on parenteral support (PS), a significantly greater proportion of teduglutide 0.05 mg/kg/day than placebo recipients achieved a {\textgreater}20\% reduction in weekly PS volume from baseline to week 20 and maintained it to week 24. The proportion of patients who had a reduction in one or more days on PS was also significant with teduglutide compared with placebo. Improved intestinal absorption and reduced PS requirements were generally maintained in the longer term. Results from a phase III trial in paediatric patients with SBS-IF dependent on PS were consistent with those in adults. Adverse events were mostly of mild to moderate severity and generally consistent with the underlying condition or known mechanism of the drug (e.g. central line-related issues, gastrointestinal events). Teduglutide is therefore a useful treatment option in children (aged {\textgreater}1 year), adolescents and adults with SBS. Copyright © 2017, Springer International Publishing Switzerland. All Right Reserved.}, journal = {Drugs}, author = {{Kim E.S.} and {Keam S.J.}}, year = {2017}, keywords = {*short bowel syndrome, *short bowel syndrome/dt [Drug Therapy], *short bowel syndrome/th [Therapy], *teduglutide, *teduglutide/ae [Adverse Drug Reaction], *teduglutide/dt [Drug Therapy], *teduglutide/pd [Pharmacology], *teduglutide/pk [Pharmacokinetics], *teduglutide/sc [Subcutaneous Drug Administration], Child, Parenteral nutrition, abdominal distension/si [Side Effect], acute cholecystitis/si [Side Effect], adolescent, adult, adverse drug reaction, article, catheter infection/co [Complication], central venous catheter, central venous catheter/am [Adverse Device Effect], clinical study, clinical trial, controlled clinical trial, controlled study, decreased appetite/si [Side Effect], disease severity, drug efficacy, drug therapy, drug tolerability, gastrointestinal dysplasia/si [Side Effect], gastrointestinal polyposis/si [Side Effect], gastrointestinal symptom/si [Side Effect], gastrointestinal tract, gastrointestinal tumor/si [Side Effect], human, infant, influenza/si [Side Effect], injection site erythema/si [Side Effect], intestinal failure, intestine absorption, intestine polyp/si [Side Effect], intestine stenosis/si [Side Effect], multicenter study (topic), nonhuman, peripheral edema/si [Side Effect], pharmacodynamic parameters, phase 3 clinical trial, phase 3 clinical trial (topic), placebo, recipient, rectum polyp/si [Side Effect], rhinopharyngitis/si [Side Effect], sepsis/co [Complication], short bowel syndrome/dt [Drug Therapy], side effect, stomach adenoma/si [Side Effect], systematic review, upper abdominal pain/si [Side Effect]} }
@misc{barrington_k.j._nitric_2017, title = {Nitric oxide for respiratory failure in infants born at or near term}, url = {http://as.wiley.com/WileyCDA/Brand/id-6.html}, abstract = {Background: Nitric oxide (NO) is a major endogenous regulator of vascular tone. Inhaled nitric oxide (iNO) gas has been investigated as treatment for persistent pulmonary hypertension of the newborn. Objectives: To determine whether treatment of hypoxaemic term and near-term newborn infants with iNO improves oxygenation and reduces rate of death and use of extracorporeal membrane oxygenation (ECMO), or affects long-term neurodevelopmental outcomes. Search methods: We used the standard search strategy of the Cochrane Neonatal Review Group to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE via PubMed (1966 to January 2016), Embase (1980 to January 2016) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 to January 2016). We searched clinical trials databases, conference proceedings and reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials. We contacted the principal investigators of studies published as abstracts to ascertain the necessary information. Selection criteria: Randomised studies of iNO in term and near-term infants with hypoxic respiratory failure, with clinically relevant outcomes, including death, use of ECMO and oxygenation. Data collection and analysis: We analysed trial reports to assess methodological quality using the criteria of the Cochrane Neonatal Review Group. We tabulated mortality, oxygenation, short-term clinical outcomes (particularly use of ECMO) and long-term developmental outcomes. Statistics: For categorical outcomes, we calculated typical estimates for risk ratios and risk differences. For continuous variables, we calculated typical estimates for weighted mean differences. We used 95\% confidence intervals and assumed a fixed-effect model for meta-analysis. Main results: We found 17 eligible randomised controlled studies that included term and near-term infants with hypoxia. Ten trials compared iNO versus control (placebo or standard care without iNO) in infants with moderate or severe severity of illness scores (Ninos 1996; Roberts 1996; Wessel 1996; Davidson 1997; Ninos 1997; Mercier 1998; Christou 2000; Clark 2000; INNOVO 2007; Liu 2008). Mercier 1998 compared iNO versus control but allowed back-up treatment with iNO for infants who continued to satisfy the same criteria for severity of illness after two hours. This trial enrolled both preterm and term infants but reported most results separately for the two groups. Ninos 1997 studied only infants with congenital diaphragmatic hernia. One trial compared iNO versus high-frequency ventilation (Kinsella 1997). Six trials enrolled infants with moderate severity of illness scores (oxygenation index (OI) or alveolar-arterial oxygen difference (A-aDO2)) and randomised them to immediate iNO treatment or iNO treatment only after deterioration to more severe criteria (Barefield 1996; Day 1996; Sadiq 1998; Cornfield 1999; Konduri 2004; Gonzalez 2010). Inhaled nitric oxide appears to have improved outcomes in hypoxaemic term and near-term infants by reducing the incidence of the combined endpoint of death or use of ECMO (high-quality evidence). This reduction was due to a reduction in use of ECMO (with number needed to treat for an additional beneficial outcome (NNTB) of 5.3); mortality was not affected. Oxygenation was improved in approximately 50\% of infants receiving iNO. The OI was decreased by a (weighted) mean of 15.1 within 30 to 60 minutes after the start of therapy, and partial pressure of arterial oxygen (PaO2) was increased by a mean of 53 mmHg. Whether infants had clear echocardiographic evidence of persistent pulmonary hypertension of the newborn (PPHN) did not appear to affect response to iNO. Outcomes of infants with diaphragmatic hernia were not improved; outcomes were slightly, but not significantly, worse with iNO (moderate-quality evidence). Infants who received iNO at less severe criteria did not have better clinical outcomes than those who were enrolled but received treatment only if their condition deteriorated. Fewer of the babies who received iNO early satisfied late treatment criteria, showing that earlier iNO reduced progression of the disease but did not further decrease mortality nor the need for ECMO (moderate-quality evidence). Incidence of disability, incidence of deafness and infant development scores were all similar between tested survivors who received iNO and those who did not. Authors' conclusions: Inhaled nitric oxide is effective at an initial concentration of 20 ppm for term and near-term infants with hypoxic respiratory failure who do not have a diaphragmatic hernia. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley \& Sons, Ltd.}, journal = {Cochrane Database of Systematic Reviews}, author = {{Barrington K.J.} and {Finer N.} and {Pennaforte T.} and {Altit G.}}, year = {2017}, keywords = {*childbirth, *nitric oxide, *respiratory failure, Cinahl, Cochrane Library, Embase, Medline, arterial oxygen tension, attributable risk, cerebral palsy, child development, clinical outcome, confidence interval, congenital diaphragm hernia, controlled clinical trial, controlled study, death, deterioration, disability, disease severity, exposure, extracorporeal oxygenation, hearing impairment, high frequency ventilation, human, hypoxia, infant, infant mortality, information processing, lung vascular resistance, meta analysis, mortality, newborn, oxygen, oxygenation, partial pressure, persistent pulmonary hypertension, placebo, priority journal, randomized controlled trial, review, sensitivity analysis, statistics, survivor, systematic review, tissue oxygenation} }
@misc{hibbert_t._exploring_2017, title = {Exploring the role of health beliefs and pregnancy related experience of women with recent gestational diabetes, in maintaining healthy lifestyles after childbirth: {Focus} group experience from a large general practice surgery in {Newham}, {East} {London}}, abstract = {Introduction: Gestational diabetes (GDM), a well recognised risk factor for subsequent Type 2 diabetes, is increasing in places with large multi-ethnic populations like East London. Aims: 1. Recruit women who have been through recent GDM pregnancy from one general practice GDM register to a focus group. 2. Understand their challenges and perceptions postpartum. Method: Twenty-seven postal invitations were sent (one in five women selected randomly from the GDM register) followed up by a telephone call to every third woman until there were ten confirmed attendees. A text message reminder was sent the day before the focus group which was facilitated by an independent researcher at a local leisure centre. Results: Two initial responses following postal invitations with a further eight after the telephone call, with 100\% attendance on the day. Focus group feedback: * There was good knowledge of diabetes risk following GDM. * An acknowledgement that it was difficult to sustain intensive lifestyle changes after delivery, but gradual improvement was possible. * Many viewed hospital consultants as "scare mongering" and felt specialist nurses conveyed messages better. * All agreed they had received intensive antenatal care but postnatal follow-up was patchy; better support immediately postpartum, preferably locally e.g. GP surgery would help them maintain antenatal changes. Conclusions: Women with previous GDM prefer sustained lifestyle support continued immediately postpartum, through more bespoke programmes, delivered locally, addressing the needs of new mothers. Participation is improved by personal invitation and telephone reminders. This is useful when delivering postpartum diabetes prevention programmes.}, journal = {Diabetic Medicine}, author = {{Hibbert T.} and {Collard A.} and {Vijayaraghavan S.}}, year = {2017}, keywords = {*England, *childbirth, *general practice, *health belief, *healthy lifestyle, *pregnancy diabetes mellitus, clinical article, consultation, doctor patient relation, female, follow up, human, lifestyle modification, mother, nurse, perception, prenatal care, prevention, scientist, surgery, telephone} }
@misc{totonchi_z._effect_2017, title = {Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: {A} randomized trial}, url = {http://cardiovascmed.com/72535.pdf}, abstract = {Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.}, journal = {Research in Cardiovascular Medicine}, author = {{Totonchi Z.} and {Rezvani H.} and {Ghorbanloo M.} and {Yazdanian F.} and {Mahdavi M.} and {Babaali N.} and {Salajegheh S.} and {Chitsazan M.}}, year = {2017}, keywords = {*chemical stress, *dexmedetomidine, *dexmedetomidine/ct [Clinical Trial], *diastolic blood pressure, *heart surgery, *hemodynamics, *infusion, *open heart surgery, *stress, Anesthesia, C reactive protein, C reactive protein/ec [Endogenous Compound], Child, adjuvant, artery catheter, article, cardiopulmonary bypass, central venous catheter, central venous pressure, clinical article, clinical trial, continuous infusion, control group, controlled clinical trial, controlled study, diastolic blood pressure, drug therapy, endogenous compound, female, fentanyl, heart rate, human, hypertension, hypotension, incidence, infant, inflammation, intensive care unit, interleukin 6, interleukin 6/ec [Endogenous Compound], lactate dehydrogenase/ec [Endogenous Compound], lactic acid, loading drug dose, lymphotoxin beta, maintenance drug dose, male, midazolam, normal human, preschool child, prospective study, randomized controlled trial, sampling, single blind procedure, skin incision, sodium chloride, sternotomy, systolic blood pressure, tumor necrosis factor/ec [Endogenous Compound]} }
@misc{paterson_m.a._increasing_2017, title = {Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with {Type} 1 diabetes mellitus}, url = {http://www3.interscience.wiley.com/journal/119818374/grouphome/home.html}, abstract = {Aim: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods: Participants with Type 1 diabetes [aged 10-40 years, HbA1c {\textless} 64 mmol/mol (8\%), BMI {\textless} 91st percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12.5, 25, 50 and 75 g. A standardized dose of insulin was given for the carbohydrate. Postprandial glycaemia was assessed by 5 h of continuous glucose monitoring. Results: Data were collected from 27 participants (15 male). A dose-response relationship was found with increasing amount of protein. A significant negative relationship between protein dose and mean excursion was seen at the 30- and 60-min time points (P = 0.007 and P = 0.002, respectively). No significant relationship was seen at the 90- and 120-min time points. Thereafter, the dose-response relationship inverted, such that there was a significant positive relationship for each of the 150-300-min time points (P {\textless} 0.004). Mean glycaemic excursions were significantly greater for all protein-added test drinks from 150 to 300 min (P {\textless} 0.005) with the 75-g protein load, resulting in a mean excursion that was 5 mmol/l higher when compared with the control test drink (P {\textless} 0.001). Conclusions: Increasing protein quantity in a low-fat meal containing consistent amounts of carbohydrate decreases glucose excursions in the early (0-60-min) postprandial period and then increases in the later postprandial period in a dose-dependent manner. Copyright © 2017 Diabetes UK.}, journal = {Diabetic Medicine}, author = {{Paterson M.A.} and {Smart C.E.M.} and {Lopez P.E.} and {Howley P.} and {Mcelduff P.} and {Attia J.} and {Morbey C.} and {King B.R.}}, year = {2017}, keywords = {*blood glucose monitoring, *insulin dependent diabetes mellitus, Child, body mass, clinical article, clinical trial, controlled clinical trial, controlled study, dose response, female, glucose, hemoglobin A1c, human, insulin, insulin treatment, lipid, lipid diet, male, postprandial state, randomized controlled trial, school child, whey} }
@article{mccarthy_pash_2016, title = {{PASH} syndrome: {A} case report with bony destruction}, volume = {74}, issn = {0190-9622}, url = {http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L72275278}, abstract = {A 44-year-old man with severe refractory hidradenitis suppurativa (HS) was admitted with cachexia and fatigue. He had a longstanding history of HS, beginning in childhood, cutaneous ulceration and acne. Since the age of 24 he had recurrent abscesses in the axillae and anogenital skin as well as cutaneous ulceration on the penile shaft, abdomen, forearms and thighs consistent with pyoderma gangrenosum (PG). On examination there was rope like dermal thickening of skin on the buttocks and perineum with florid erythema and multiple fistula openings with purulent discharge consistent with Hurley stage III disease. Large atrophic telangiectatic scars were present on the abdomen and thighs suggestive of quiescent pyoderma gangrenosum. CT scan of thorax, abdomen and pelvis showed lytic destruction of the sacrum most likely reflecting chronic osteomyelitis from direct extension of the inflammatory process through subcutaneous tissue and bone into the presacral space. The patient was treated with meropenem 1 g/day for seven days with marked improvement in HS. Inflammatory markers returned to normal and infliximab (0.5 mg/kg) was commenced to maintain remission. Hidradenitis suppurativa is a chronic autoinflammatory disorder characterized by acneiform follicular occlusion and inflammation of the terminal follicular epithelium in apocrine gland bearing skin that leads to relapsing purulent infections, scarring and sinus formation. The clinical presentation of severe HS, acne, pilonidal sinus and PG may be consistent with the recently recognised PASH syndrome. Our patient has never had joint symptoms suggestive of arthritis and therefore clinically does not fit with previously described PAPA (pyogenic sterile arthritis, PG, acne) or PAPASH (PAPA plus HS) syndromes. Imaging plays an important role in assessing extent of disease, characterizing active lesions and recognizing complications. To our knowledge this is the first case report of bony destruction of the coccyx by direct extension of HS.}, number = {5}, journal = {Journal of the American Academy of Dermatology}, author = {McCarthy, S. and Foley, C. and Dvorakova, V. and Quinlan, C. and Murphy, M. and Maher, M.}, year = {2016}, keywords = {American, abdomen, abscess, acne, apocrine gland, arthritis, autoinflammatory disease, axilla, bone, buttock, cachexia, case report, childhood, chronic osteomyelitis, coccygeal bone, computer assisted tomography, dermatology, epithelium, erythema, examination, fatigue, fistula, forearm, human, imaging, infection, inflammation, infliximab, male, marker, meropenem, occlusion, patient, pelvis, perineum, pilonidal sinus, pyoderma gangrenosum, remission, sacrum, scar, scar formation, skin, subcutaneous tissue, suppurative hidradenitis, thigh, thorax, ulcer}, pages = {AB65} }
@misc{ferre_c.l._caregiver-directed_2016, title = {Caregiver-directed home-based intensive bimanual training in young children with unilateral spastic cerebral palsy: {A} randomized trial}, url = {http://www.wiley.com/bw/journal.asp?ref=0012-1622&site=1}, abstract = {Aim: To examine the efficacy of caregiver-directed, home-based intensive bimanual training in children with unilateral spastic cerebral palsy (USCP) using a randomized control trial. Method: Twenty-four children (ages 2y 6mo-10y 1mo; 10 males, 14 females) performed home-based activities directed by a caregiver for 2 hours per day, 5 days per week, for 9 weeks (total=90h). Cohorts of children were age-matched into groups and randomized to receive home-based hand-arm bimanual intensive therapy (H-HABIT; n=12) or lower-limb functional intensive training (LIFT-control; n=12). Caregivers were trained before the intervention and supervised remotely via telerehabilitation. Dexterity and bimanual hand function were assessed using the Box and Blocks test (BBT) and the Assisting Hand Assessment (AHA) respectively. Caregiver perception of functional goals was measured using the Canadian Occupational Performance Measure (COPM). Results: H-HABIT showed greater improvement on the BBT compared to LIFT-control and no improvement on the AHA. H-HABIT demonstrated significant improvement in COPM-Performance compared to LIFT-control and both groups showed equal improvement in COPM-Satisfaction. Interpretation: H-HABIT improved dexterity and performance of functional goals, but not bimanual performance, in children with USCP compared to a control group receiving intervention of equal intensity/duration that also controlled for increased caregiver attention. Home-based models provide a valuable, family-centered approach to achieve increased treatment intensity. Copyright © 2016 Mac Keith Press.}, journal = {Developmental Medicine and Child Neurology}, author = {{Ferre C.L.} and {Brandao M.} and {Surana B.} and {Dew A.P.} and {Moreau N.G.} and {Gordon A.M.}}, year = {2016}, keywords = {*caregiver, *cerebral palsy, Child, attention, clinical article, clinical trial, control group, controlled clinical trial, controlled study, endogenous compound, female, hand function, human, intensive care, lower limb, male, model, perception, preschool child, randomized controlled trial, satisfaction, telerehabilitation} }
@article{martinez-rios_sterile_2016, title = {Sterile pyogenic arthritis pyoderma gangrenosum, and acne ({PAPA}) syndrome: {Musculoskeletal} imaging findings and common differential diagnosis in children}, volume = {46}, issn = {1432-1998}, url = {http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L72287938}, abstract = {Purpose or Case Report: Sterile pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA syndrome) is a rare autosomal dominant inherited entity due to a missense mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene, characterized by typical recurrent episodes of sterile pyogenic arthritis, either spontaneous or following a trauma, and skin manifestations characterized by pyoderma gangrenosum and acne. The articular manifestation is seen in the first decade of life, where most of the initial episodes are treated as septic arthritis. Cutaneous manifestations appear in early adulthood. Although uncommon, the potential therapeutic and clinical implications due to the rapidly destructive nature of PAPA syndrome warrant a prompt diagnosis. We present two unrelated pediatric patients from different institutions with genetically confirmed PAPA syndrome. The purpose of this study was to illustrate the musculoskeletal radiologic spectrum of findings of PAPA syndrome, and to discuss the differential diagnostic entities commonly seen in children. A second objective was to review the clinical and laboratory findings that allow diagnosis of PAPA syndrome Methods \& Materials: Patients' consent were obtained. We reviewed the imaging features of PAPA syndrome in different imaging modalities including plain radiograph, ultrasound, and magnetic resonance imaging, and we included representative cases of more common musculoskeletal diagnostic entities that present with similar imaging and clinical features in children Results: Many of the imaging features seen in PAPA syndrome overlap with other clinical conditions including septic arthritis, osteomyelitis and juvenile idiopathic arthritis, including joint effusion, synovial thickening and extensive soft tissue swelling Conclusions: PAPA syndrome would not be suspected initially based on imaging appearance alone, but should be considered in cases of recurrent septic arthritis or in those demonstrating skin manifestations. Radiologists familiarization with the syndrome may allow them to recognize the condition earlier in its course.}, number = {(Jariwala M.; Highmore K.; Duffy K.W.; Laxer R.; Stimec J.)}, journal = {Pediatric Radiology}, author = {Martinez-Rios, C. and Jariwala, M. and Highmore, K. and Duffy, K.W. and Laxer, R. and Stimec, J.}, year = {2016}, keywords = {PAPA syndrome, X ray film, acne, adulthood, autosomal dominant inheritance, bacterial arthritis, case report, child, clinical feature, diagnosis, differential diagnosis, edema, gene, human, imaging, injury, joint effusion, juvenile rheumatoid arthritis, laboratory, missense mutation, nuclear magnetic resonance imaging, osteomyelitis, patient, phosphatase, proline, pyoderma gangrenosum, radiologist, radiology, serine, skin manifestation, soft tissue, synapsin I, threonine, ultrasound}, pages = {S246} }
@misc{ratnayake_a._pharmacokinetics_2016, title = {Pharmacokinetics and pharmacodynamics of albuterol multidose dry powder inhaler and albuterol hydrofluoroalkane in children with asthma}, url = {http://www.ingentaconnect.com/search/download?pub=infobike%3a%2f%2focean%2faap%2f2016%2f00000037%2f00000005%2fart00011&mimetype=application%2fpdf&exitTargetId=1473325081442}, abstract = {Background: Many children struggle with the use of albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. Objective: To compare the pharmacokinetics (PK), pharmacodynamics (PD), and tolerability of albuterol MDPI and albuterol HFA after a single inhaled dose in children with asthma. Methods: This single-center, open-label, two-period crossover study randomized children to albuterol MDPI or HFA 180 mug on two treatment days with a 4- to 14-day washout. Plasma albuterol concentrations were measured before the dose and up to 10 hours after the dose to determine the primary PK values of area under the plasma concentration-versus-time curve from time 0 to the last measurable concentration (AUC0-t), maximum observed concentration (Cmax), and AUC from time 0 extrapolated to infinity (AUC0-inf). Heart rate and blood pressure before the dose and after the dose were monitored for PD effects, and adverse events (AE) were monitored for overall safety. Results: Fifteen children, ages 6-11 years, were included (PK, n = 13 for time to Cmax and terminal half-life of elimination; n = 12 for AUC and Cmax due to incomplete data). AUC0-t (geometric mean ratio [GMR] 1.056 [90\% confidence interval \{CI\}, 0.88 -1.268]) and AUC0-inf (GMR 0.971 [90\% CI, 0.821-1.147]) were comparable between treatments. Cmax was larger for albuterol MDPI versus HFA (GMR 1.340 [90\% CI, 1.098 -1.636]). PD parameters between the treatments were comparable. No deaths, serious AEs, treatment-emergent AEs, or withdrawals due to AEs were reported for either treatment. Conclusion: Albuterol MDPI and albuterol HFA had comparable PK and PD in children after a single 180-mug dose. Copyright ©2016, OceanSide Publications, Inc., U.S.A.}, journal = {Allergy and Asthma Proceedings}, author = {{Ratnayake A.} and {Taveras H.} and {Iverson H.} and {Shore P.}}, year = {2016}, keywords = {*albuterol hydrofluoroalkane/ae [Adverse Drug Reaction], *albuterol hydrofluoroalkane/cm [Drug Comparison], *albuterol hydrofluoroalkane/ct [Clinical Trial], *albuterol hydrofluoroalkane/dt [Drug Therapy], *albuterol hydrofluoroalkane/ih [Inhalational Drug Administration], *albuterol hydrofluoroalkane/pk [Pharmacokinetics], *antiasthmatic agent/ae [Adverse Drug Reaction], *antiasthmatic agent/cm [Drug Comparison], *antiasthmatic agent/ct [Clinical Trial], *antiasthmatic agent/dt [Drug Therapy], *antiasthmatic agent/ih [Inhalational Drug Administration], *antiasthmatic agent/pk [Pharmacokinetics], *asthma, *asthma/dt [Drug Therapy], *dry powder inhaler, *dry powder inhaler/ct [Clinical Trial], *dry powder inhaler/dc [Device Comparison], *inhaler, *inhaler/ct [Clinical Trial], *inhaler/dc [Device Comparison], *multidose dry powder inhaler, *multidose dry powder inhaler/ct [Clinical Trial], *multidose dry powder inhaler/dc [Device Comparison], *pharmacodynamics, *salbutamol, *salbutamol/ae [Adverse Drug Reaction], *salbutamol/cm [Drug Comparison], *salbutamol/cr [Drug Concentration], *salbutamol/ct [Clinical Trial], *salbutamol/dt [Drug Therapy], *salbutamol/ih [Inhalational Drug Administration], *salbutamol/pk [Pharmacokinetics], Child, Pharmacokinetics, adverse drug reaction, area under the curve, asthma/dt [Drug Therapy], blood pressure, blood pressure monitoring, clinical article, clinical trial, conference paper, confidence interval, controlled clinical trial, controlled study, crossover procedure, death, drug blood level, drug efficacy, drug elimination, drug half life, drug monitoring, drug safety, drug withdrawal, female, fluorinated hydrocarbon, half life time, heart rate, human, human tissue, male, maximum plasma concentration, pharmacodynamics, phase 1 clinical trial, plasma concentration-time curve, preschool child, randomized controlled trial, safety, side effect, time to maximum plasma concentration, unclassified drug, unspecified side effect/si [Side Effect]} }
@incollection{godfrey_end--life_2016, title = {End-of-life issues for {LGBT} elders}, url = {http://uml.idm.oclc.org/login?url=https://search.proquest.com/docview/1862755771?accountid=14569}, abstract = {This chapter explores the end-of-life issues and what makes end-of-life issues different for LGBT adults. The laws and policies relating to end-of-life have many presumptions that favor family, specifically biological or adoptive family and family from marriage. These presumptions impact health care decision-making, visitation policies, health insurance, health benefits, retirement plans, taxation, and inheritance rules. The expansion of same-sex marriage is changing this picture, but a great deal of work remains to be done. Societal homophobia impacts access to care, relationship recognition, and even funeral planning. Ageism is common in some parts of the LGBT community, casting a shadow over many LGBT elders. Many of die current generation of LGBT elders survived the darkest days of AIDS and HIV, and this experience influences their views on aging and end-of-life. (PsycINFO Database Record (c) 2017 APA, all rights reserved) (Source: chapter)}, language = {English}, booktitle = {Handbook of {LGBT} elders: {An} interdisciplinary approach to principles, practices, and policies}, publisher = {Springer Science + Business Media, New York, NY}, author = {Godfrey, David}, editor = {Harley, Debra A. and Teaster, Pamela B.}, year = {2016}, note = {DOI: 10.1007/978-3-319-03623-6\_22}, keywords = {3370:Health \& Mental Health Services, Adulthood (18 yrs \& older), Age Discrimination, Aged (65 yrs \& older), Ageism, Clinical Case Study, Decision Making, Disabilities, Female, Guardianship, Health Care Services, Human, Incapacity, Inheritance, Male, Palliative Care, Presumptions, Professional Ethics, Psychology: Professional \& Research, Quality of Life, Surrogate, bookitem}, pages = {439--454, Chapter xviii, 691 Pages} }
@incollection{harley_impact_2016, title = {Impact of healthcare reform on {LGBT} elders}, url = {http://uml.idm.oclc.org/login?url=https://search.proquest.com/docview/1862755097?accountid=14569}, abstract = {The purpose of this chapter was to examine the impact of healthcare reform in the USA on LGBT elders, especially the Affordable Care Act (ACA). Attention is given to health disparities and coming out risk factors for LGBT elders, health systems challenges for LGBT elders, advantages and disadvantages of healthcare reform on LGBT elders, and future directions of healthcare reform in the USA. Where appropriate, discussion from an international perspective is included, especially Canada and the UK. It is not the intent of this chapter to endorse any point of view over the other or to be advisory about healthcare issues. The intent is to present multiple perspectives concerning the benefits and debates of healthcare reform on seniors, especially LGBT elders. (PsycINFO Database Record (c) 2017 APA, all rights reserved) (Source: chapter)}, language = {English}, booktitle = {Handbook of {LGBT} elders: {An} interdisciplinary approach to principles, practices, and policies}, publisher = {Springer Science + Business Media, New York, NY}, author = {Harley, Debra A.}, editor = {Harley, Debra A. and Teaster, Pamela B.}, year = {2016}, note = {DOI: 10.1007/978-3-319-03623-6\_19}, keywords = {3370:Health \& Mental Health Services, Adulthood (18 yrs \& older), Aged (65 yrs \& older), Aging, Cross Cultural Differences, Empirical Study, Female, Health Care Reform, Health Disparities, Healthcare reform, Human, LGBT elders' health, LGBT health disparities, Longitudinal Study, Male, Psychology: Professional \& Research, Quantitative Study, Retrospective Study, Risk Factors, Transgender, bookitem}, pages = {375--389, Chapter xviii, 691 Pages} }
@article{tang_tools_2016, title = {Tools for {Predicting} the {Functional} {Impact} of {Nonsynonymous} {Genetic} {Variation}}, volume = {203}, issn = {1943-2631}, doi = {10.1534/genetics.116.190033}, abstract = {As personal genome sequencing becomes a reality, understanding the effects of genetic variants on phenotype-particularly the impact of germline variants on disease risk and the impact of somatic variants on cancer development and treatment-continues to increase in importance. Because of their clear potential for affecting phenotype, nonsynonymous genetic variants (variants that cause a change in the amino acid sequence of a protein encoded by a gene) have long been the target of efforts to predict the effects of genetic variation. Whole-genome sequencing is identifying large numbers of nonsynonymous variants in each genome, intensifying the need for computational methods that accurately predict which of these are likely to impact disease phenotypes. This review focuses on nonsynonymous variant prediction with two aims in mind: (1) to review the prioritization methods that have been developed to date and the principles on which they are based and (2) to discuss the challenges to further improving these methods.}, language = {eng}, number = {2}, journal = {Genetics}, author = {Tang, Haiming and Thomas, Paul D.}, year = {2016}, pmid = {27270698}, pmcid = {PMC4896183}, keywords = {Genome, Human, Genome-Wide Association Study, Genomics, Humans, Polymorphism, Genetic, genetic variation, human disease, phenotypic effects, protein mutation}, pages = {635--647}, }
@misc{bannon_l._impact_2016, title = {Impact of non-pharmacological interventions on prevention and treatment of delirium in critically ill patients: {Protocol} for a systematic review of quantitative and qualitative research}, url = {http://www.systematicreviewsjournal.com/}, abstract = {Background: Critically ill patients have an increased risk of developing delirium during their intensive care stay. To date, pharmacological interventions have not been shown to be effective for delirium management but non-pharmacological interventions have shown some promise. The aim of this systematic review is to identify effective non-pharmacological interventions for reducing the incidence or the duration of delirium in critically ill patients. Methods: We will search MEDLINE, EMBASE, CINAHL, Web of Science, AMED, psycINFO and the Cochrane Library. We will include studies of critically ill adults and children. We will include randomised trials and controlled trials which measure the effectiveness of one or more non-pharmacological interventions in reducing incidence or duration of delirium in critically ill patients. We will also include qualitative studies that provide an insight into patients and their families' experiences of delirium and non-pharmacological interventions. Two independent reviewers will assess studies for eligibility, extract data and appraise quality. We will conduct meta-analyses if possible or present results narratively. Qualitative studies will also be reviewed by two independent reviewers, and a specially designed quality assessment tool incorporating the CASP framework and the POPAY framework will be used to assess quality. Discussion: Although non-pharmacological interventions have been studied in populations outside of intensive care units and multicomponent interventions have successfully reduced incidence and duration of delirium, no systematic review of non-pharmacological interventions specifically targeting delirium in critically ill patients have been undertaken to date. This systematic review will provide evidence for the development of a multicomponent intervention for delirium management of critically ill patients that can be tested in a subsequent multicentre randomised trial. Systematic review registration: PROSPERO CRD42015016625 Copyright © 2016 Bannon et al.}, journal = {Systematic Reviews}, author = {{Bannon L.} and {McGaughey J.} and {Clarke M.} and {McAuley D.F.} and {Blackwood B.}}, year = {2016}, keywords = {*critical illness, *critically ill patient, *delirium, *delirium/pc [Prevention], *delirium/th [Therapy], *intensive care unit, *medical procedures, *qualitative research, *registration, Child, Cinahl, Cochrane Library, Embase, Medline, PsycINFO, Web of Science, adult, article, bright light therapy, cognitive therapy, controlled clinical trial, critically ill patient, ear plug, education, exercise, extract, eye mask, family study, human, incidence, intensive care unit, lighting control, mask, meta analysis, music therapy, noise reduction, orientation, outcome assessment, physiotherapy, priority journal, publication, qualitative research, quality control, quantitative study, randomized controlled trial, randomized controlled trial (topic), risk factor, scientific literature, sensitivity analysis, systematic review} }
@inProceedings{ title = {FreeSense: Indoor Human Identification with Wi-Fi Signals}, type = {inProceedings}, year = {2016}, identifiers = {[object Object]}, keywords = {80211,analysis,analysissensorsshapetime,analysissmart,analysiswireless,biometric,channelscsi,characteristicschannel,component,computer,discrete,environmentdynamic,environmentfeature,extractionieee,home,human,identificationdtw,identificationmotion,identificationprincipal,information,interactionindoor,lanwireless,locomotionprincipal,navigationprincipal,patternnonintrusive,rf,series,seriescsi,seriesdiscrete,shape,signalbody,standardlegged,state,techniquedwtfreesensepcawi-fi,techniquehuman-computer,time,transformdomestic,transformshuman,warping,waveform-based,wavelet}, pages = {1-7}, websites = {http://dx.doi.org/10.1109/GLOCOM.2016.7841847}, publisher = {IEEE}, id = {973cb24b-ec5f-3be9-a1e4-da55d505d19a}, created = {2018-07-12T21:32:38.958Z}, file_attached = {false}, profile_id = {f954d000-ce94-3da6-bd26-b983145a920f}, group_id = {b0b145a3-980e-3ad7-a16f-c93918c606ed}, last_modified = {2018-07-12T21:32:38.958Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {xin2016}, source_type = {inproceedings}, private_publication = {false}, bibtype = {inProceedings}, author = {Xin, T and Guo, B and Wang, Z and Li, M and Yu, Z and Zhou, X}, booktitle = {Global Communications Conference (GLOBECOM)} }
@article{ho_findings_2016, title = {Findings from a community-based vaccination programme against influenza and pneumococcal disease for seniors in {Singapore}}, volume = {45}, issn = {0304-4602}, url = {http://www.annals.edu.sg/pdf/45VolNo9Sep2016/SHBC2016.pdf http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed17&NEWS=N&AN=612898367}, abstract = {Background \& Hypothesis: In Singapore, influenza and pneumococcal vaccine uptake rates in the elderly are very low. Our institution organised a community-based programme providing these vaccines at no cost to seniors, to encourage vaccine uptake and to monitor its impact on health outcomes. Method(s): Our institution collaborated with multiple community-based and government stakeholders. Active recruitment was carried out using educational talks and engagement by our community partners. The events were sited at various community venues and comprised vaccinations given by our institution's Travel Clinic nurses, as well as educational sessions on healthy ageing topics. Result(s): Nine vaccination events were held from November 2015 to January 2016. A total of 656 seniors were vaccinated, with 636 receiving influenza vaccine and 632 receiving pneumococcal conjugate (PCV13) vaccine. The median age of participants was 72 years (interquartile range 62-77 years). Majority were female (64.6\%), of Chinese ethnicity (84.4\%), received primary school level education (42.4\%), and resided in 1- or 2-room government housing rental flats (44.4\%). Chronic disease prevalence was high, with 60.8\% having hypertension, 57.6\% having hyperlipidaemia and 28.1\% having diabetes. Four percent reported influenza vaccination in the past year, and 4.3\% reporting previous pneumococcal (PPSV23) vaccination. Post-vaccination, 1 patient reported systemic side effects (persistent rash for 1 month). Discussion \& Conclusion(s): In this cohort of seniors, a high proportion came from the lower education and lower income strata. The burden of chronic disease was high and baseline vaccination rates were low. Community-based partnerships are a suitable means of recruiting such elderly participants for vaccination, to reduce their risk of severe illness from pneumonia and influenza.}, language = {English}, number = {9 Supplement 1}, journal = {Annals of the Academy of Medicine Singapore}, author = {Ho, H. and Chen, W. K. and Lim, P. L. and Chow, A.}, year = {2016}, keywords = {*Singapore, *influenza vaccination, *pneumococcal infection, Pneumococcus vaccine, aged, aging, case report, conjugate, controlled study, diabetes mellitus, ethnicity, female, government, hospital, housing, human, hyperlipidemia, hypertension, influenza vaccine, nurse, pneumonia, prevalence, primary school, rash, travel}, pages = {S232}, }
@article{selmouni_acceptability_2015, title = {Acceptability of the human papilloma virus vaccine among {Moroccan} parents: a population-based crosssectional study.}, volume = {21}, issn = {1020-3397}, url = {http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=110150320&site=ehost-live}, doi = {10.26719/2015.21.8.555}, abstract = {Data about the public's awareness and acceptability of the human papilloma virus (HPV) vaccine are lacking in the Eastern Mediterranean Region. This study aimed to explore parental acceptability of HPV vaccination for their daughters in Morocco. A cross-sectional survey was carried out among mothers and fathers of girls aged 12-15 years at 12 middle schools from 6 regions of Morocco. Despite weak knowledge of genital warts and HPV infection, acceptability of the HPV vaccine was 76.8\% (95\% CI: 73.3-79.9\%) among mothers and 68.9\% (95\% CI: 65.2-72.5\%) among fathers. Only 8.8\% of mothers and 7.0\% of fathers were against administration of the HPV vaccine to their daughters. Predictors of parents' acceptance of the HPV vaccine were living in precarious housing/slums and low household income (for mothers) and living in urban areas (for fathers). These results will be useful for preparing the introduction of the HPV vaccine in health ministry programmes.}, number = {8}, journal = {Eastern Mediterranean Health Journal}, author = {Selmouni, F. and Zidouh, A. and Nejjari, C. and Bekkali, R.}, month = aug, year = {2015}, note = {Publisher: World Health Organization}, keywords = {Academic Medical Centers, Adolescence, Adult, Cervix Neoplasms -- Prevention and Control, Confidence Intervals, Cross Sectional Studies, Data Analysis Software, Descriptive Statistics, Female, Funding Source, Human, Interviews, Male, Middle Age, Morocco, Multicenter Studies, Multivariate Analysis, Odds Ratio, Papillomavirus Vaccine -- Classification, Papillomavirus Vaccine -- Therapeutic Use, Parental Attitudes, Surveys}, pages = {555--563}, }
@article{ title = {Vaccines for the prevention of seasonal influenza in patients with diabetes: systematic review and meta-analysis}, type = {article}, year = {2015}, identifiers = {[object Object]}, pages = {53}, volume = {13}, websites = {http://www.biomedcentral.com/1741-7015/13/53}, id = {2cc07ac9-3895-3d7d-840a-282f79e47294}, created = {2015-09-09T15:56:50.000Z}, file_attached = {true}, profile_id = {7a0fec24-6ec6-312f-956e-f210abd2cdb7}, group_id = {943817ab-6073-3383-a1c5-963a6e7efbea}, last_modified = {2015-09-14T17:18:41.000Z}, tags = {VDECGA,VDECICIDFLUREV,VDECL4,VDECVI}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {VDECICIDFLUREV; VDECSG; GA}, bibtype = {article}, author = {Remschmidt, Cornelius and Wichmann, Ole and Harder, Thomas}, journal = {BMC Medicine}, number = {1} }
@book{ title = {Redox ‑ and non ‑ redox ‑ metal ‑ induced formation of free radicals and their role in human disease}, type = {book}, year = {2015}, identifiers = {[object Object]}, keywords = {disease,human,metals,oxidative stress,reactive oxygen species,toxicity}, id = {fff866b0-4ed8-3a96-a2ca-265b853809ec}, created = {2016-08-10T10:10:09.000Z}, file_attached = {true}, profile_id = {5d250c3e-485a-3099-8087-b35242bd2203}, group_id = {a9625e9e-5a77-317b-ab12-c1d6dcc9ef27}, last_modified = {2016-08-10T10:10:35.000Z}, read = {true}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Toxicol2015}, bibtype = {book}, author = {Toxicol, Arch and Valko, Marian and Jomova, Klaudia and Rhodes, Christopher J and Kuc, Kamil} }
@misc{plambech_m.z._dexmedetomidine_2015, title = {Dexmedetomidine in the pediatric population: {A} review}, url = {http://www.minervamedica.it/en/getpdf/sbNvoPlJhvv6bbyfsqY76tEZcB64PRPRZhQ7XFLHe60Q6OIPvcRxmU6QbTTdsDC59xcyai%252BPQuY95g446wPjIA%253D%253D/R02Y2015N03A0320.pdf}, abstract = {Dexmedetomidine, an alpha-2 agonist approved only for sedation in adult intensive care patients, is increasingly used off-label in- and outside Europe in the pediatric setting for various indications such as to prevent agitation, as premedication in the form of intranasal, buccal and oral solution, as adjunct for elective surgery, as sedative for magnetic resonance imaging, as intraoperative analgesia, for extracorporeal shock wave lithotripsy, and as adjuvant to ropi- and bupivacaine for nerve blocks. Dexmedetomidine is also used intravenously at different intensive care units with the purpose of sedation of children. In this paper, we assess 51 minor trials in the form of 44 randomized controlled trials and 7 prospective observational studies in an attempt to update the available evidence on dexmedetomidine use in pediatrics. Furthermore, we discuss its potential indications, benefits and adverse effects. However, it is important to state that much of the existing evidence favoring dexmedetomidine in children is either extrapolated from adult studies or based on small randomized controlled trials and observational studies with their inherent methodological shortcomings and confounding factors. Based on the best current evidence dexmedetomidine is found suitable and safe for various indications. However, in order to discover its full potential, indications, dosing and safety profile for various ages and procedures, it should urgently be examined by conducting good quality pediatric trials. Finally, we provide the readers with guidance on how to apply and dose dexmedetomidine for pediatric sedation and for other indications. Copyright COPYRIGHT © 2015 EDIZIONI MINERVA MEDICA.}, journal = {Minerva Anestesiologica}, author = {{Plambech M.Z.} and {Afshari A.}}, year = {2015}, keywords = {*anesthesia, *child, *deep sedation, *dexmedetomidine, *dexmedetomidine/ae [Adverse Drug Reaction], *dexmedetomidine/ct [Clinical Trial], *dexmedetomidine/na [Intranasal Drug Administration], *human, *pediatrics, *population, Child, Europe, adjuvant, adolescent, adult, adverse drug reaction, agitation, agonist, analgesia, article, bupivacaine, cardiovascular effect, clinical protocol, elective surgery, extracorporeal lithotripsy, human, infant, intensive care, intensive care unit, intranasal drug administration, intraoperative analgesia, intraoperative period, meta analysis (topic), nerve block, newborn, nuclear magnetic resonance imaging, observational study, patient, pediatrics, perioperative period, phase 1 clinical trial (topic), premedication, procedures, randomized controlled trial (topic), reading, safety, sedation, sedative agent, side effect/si [Side Effect], systematic review (topic)} }
@article{ kidd_influenza_2014, title = {Influenza viruses: update on epidemiology, clinical features, treatment and vaccination}, volume = {20}, issn = {1531-6971}, shorttitle = {Influenza viruses}, doi = {10.1097/MCP.0000000000000049}, abstract = {PURPOSE OF REVIEW: In the last decade, sporadic and lethal human disease caused by zoonotic avian influenza viruses, and the seasonal activity of human H1N1 2009 pandemic type have driven intense epidemiological and laboratory studies into the virus life cycle. This article highlights major developments from mid-2012 to early 2014. RECENT FINDINGS: Advances in molecular techniques and efficient rollout of diagnostic tests have enabled the rapid identification of clinical cases and detailed genetic sequencing of viral genomes. Studies have contributed widely to the understanding of how and when influenza viruses circulate, what determines their innate pathogenicity in particular hosts and whether host cofactors influence disease severity. Other imperatives include investigations into how influenza can be better prevented by vaccination, or treated with antiviral drugs. SUMMARY: Avian influenza viruses present a continuous threat to human populations. There is a need for sustained surveillance and downstream research to evaluate the potential for future pandemics.}, language = {eng}, number = {3}, journal = {Current Opinion in Pulmonary Medicine}, author = {Kidd, Mike}, month = {May}, year = {2014}, pmid = {24637227}, keywords = {Animals, Antiviral Agents, DNA, Viral, Drug Resistance, Viral, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H7N9 Subtype, Influenza A virus, Influenza in Birds, Influenza, Human, Male, Pandemics, Poultry, Seasons, Sentinel Surveillance, Sequence Analysis, DNA, Viral Vaccines, Zanamivir}, pages = {242--246} }
@article{ vellozzi_guillain-barre_2014, title = {Guillain-{Barre} syndrome, influenza, and influenza vaccination: the epidemiologic evidence}, volume = {58}, issn = {1537-6591}, shorttitle = {Guillain-{Barre} syndrome, influenza, and influenza vaccination}, doi = {10.1093/cid/ciu005}, abstract = {Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide, and is thought to be immune-mediated. It is preceded by upper respiratory or gastrointestinal infection in about two-thirds of cases and is associated with some viral infections, including influenza. GBS has also been associated with the 1976 swine-influenza vaccine. Thereafter, some studies have shown a small increased risk of GBS following receipt of seasonal and 2009 H1N1 monovalent influenza vaccines. Studies over the years have also shown an increased risk of GBS following influenza infection, and the magnitude of risk is several times greater than that following influenza vaccination. Because GBS is rare, and even rarer following vaccination, it is difficult to estimate precise risk. We try to shed light on the complex relationship of GBS and its association with influenza and influenza vaccines over the past 35 years.}, language = {eng}, number = {8}, journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America}, author = {Vellozzi, Claudia and Iqbal, Shahed and Broder, Karen}, month = {April}, year = {2014}, pmid = {24415636}, keywords = {Guillain-Barre Syndrome, Humans, Incidence, Influenza Vaccines, Influenza, Human, Vaccination}, pages = {1149--1155} }
@article{ thomas_is_2014, title = {Is influenza-like illness a useful concept and an appropriate test of influenza vaccine effectiveness?}, volume = {32}, issn = {1873-2518}, doi = {10.1016/j.vaccine.2014.02.059}, abstract = {PURPOSE: To assess the utility of "influenza-like illness" (ILI) and whether it appropriately tests influenza vaccine effectiveness. PRINCIPAL RESULTS: The WHO and CDC definitions of "influenza-like illness" are similar. However many studies use other definitions, some not specifying a temperature and requiring specific respiratory and/or systemic symptoms, making many samples non-comparable. Most ILI studies find less than 25% of cases are RT-PCR-positive, those which test for other viruses and bacteria usually find multiple other pathogens, and most identify no pathogen in about 50% of cases. ILI symptom and symptom combinations do not have high sensitivity or specificity in identifying PCR-positive influenza cases. Rapid influenza diagnostic tests are increasingly used to screen ILI cases and they have low sensitivity and high specificity when compared to RT-PCR in identifying influenza. MAIN CONCLUSIONS: The working diagnosis of ILI presumes influenza may be involved until proven otherwise. Health care workers would benefit by renaming the WHO and CDC ILI symptoms and signs as "acute respiratory illness" and also using the WHO acute severe respiratory illness definition if the illness is severe and meets this criterion. This renaming would shift attention to identify the viral and bacterial pathogens in cases and epidemics, identify new pathogens, implement vaccination plans appropriate to the identified pathogens, and estimate workload during the viral season. Randomised controlled trials testing the effectiveness of influenza vaccine require all participants to be assessed by a gold standard (RT-PCR). ILI has no role in measuring influenza vaccine effectiveness. ILI is well established in the literature and in the operational definition of many surveillance databases and its imprecise definition may be inhibiting progress in research and treatment. The current ILI definition could with benefit be renamed "acute respiratory illness," with additional definitions for "severe acute respiratory illness" (SARI) with RT-PCR testing for pathogens to facilitate prevention and treatment.}, language = {eng}, number = {19}, journal = {Vaccine}, author = {Thomas, Roger E.}, month = {April}, year = {2014}, pmid = {24582634}, keywords = {Centers for Disease Control and Prevention (U.S.), Global Health, Humans, Influenza Vaccines, Influenza, Human, Respiratory Tract Diseases, United States, Vaccination}, pages = {2143--2149} }
@article{ title = {Eye-hand coordination in on-line visuomotor adjustments}, type = {article}, year = {2014}, identifiers = {[object Object]}, keywords = {Automatic pilot,Eye-hand coordination,Human,On-line motor control,Reaching,Saccades}, pages = {441-445}, volume = {25}, id = {e0f30b19-5716-3785-a1ba-b6a930209236}, created = {2018-11-22T20:16:45.910Z}, file_attached = {true}, profile_id = {320a2cca-e89a-3024-8447-b202ac8efe57}, group_id = {1378139f-e3de-3b78-a9d2-5c85c2da309f}, last_modified = {2018-11-22T20:17:17.774Z}, tags = {Author=A,Type=small}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Abekawa2014}, private_publication = {false}, abstract = {When we perform a visually guided reaching action, the brain coordinates our hand and eye movements. Eye-hand coordination has been examined widely, but it remains unclear whether the hand and eye motor systems are coordinated during on-line visuomotor adjustments induced by a target jump during a reaching movement. As such quick motor responses are required when we interact with dynamic environments, eye and hand movements could be coordinated even during on-line motor control. Here, we examine the relationship between online hand adjustment and saccadic eye movement. In contrast to the well-known temporal order of eye and hand initiations where the hand follows the eyes, we found that on-line hand adjustment was initiated before the saccade onset. Despite this order reversal, a correlation between hand and saccade latencies was observed, suggesting that the hand motor system is not independent of eye control even when the hand response was induced before the saccade. Moreover, the latency of the hand adjustment with saccadic eye movement was significantly shorter than that with eye fixation. This hand latency modulation cannot be ascribed to any changes of visual or oculomotor reafferent information as the saccade was not yet initiated when the hand adjustment started. Taken together, the hand motor system would receive preparation signals rather than reafference signals of saccadic eye movements to provide quick manual adjustments of the goal-directed eye-hand movements.}, bibtype = {article}, author = {Abekawa, Naotoshi and Inui, Toshio and Gomi, Hiroaki}, journal = {NeuroReport}, number = {7} }
@article{ jit_key_2013, title = {Key issues for estimating the impact and cost-effectiveness of seasonal influenza vaccination strategies}, volume = {9}, issn = {2164-554X}, doi = {10.4161/hv.23637}, abstract = {Many countries have considered or are considering modifying their seasonal influenza immunization policies. Estimating the impact of such changes requires understanding the existing clinical and economic burden of influenza, as well as the potential impact of different vaccination options. Previous studies suggest that vaccinating clinical risk groups, health care workers, children and the elderly may be cost-effective. However, challenges in such estimation include: (1) potential cases are not usually virologically tested; (2) cases have non-specific symptoms and are rarely reported to surveillance systems; (3) endpoints for influenza proxies (such as influenza-like illness) need to be matched to case definitions for treatment costs, (4) disease burden estimates vary from year to year with strain transmissibility, virulence and prior immunity, (5) methods to estimate productivity losses due to influenza vary, (6) vaccine efficacy estimates from trials differ due to variation in subtype prevalence, vaccine match and case ascertainment, and (7) indirect (herd) protection from vaccination depends on setting-specific variables that are difficult to directly measure. Given the importance of knowing the impact of changes to influenza policy, such complexities need careful treatment using tools such as population-based trial designs, meta-analyses, time-series analyses and transmission dynamic models.}, language = {eng}, number = {4}, journal = {Human Vaccines \& Immunotherapeutics}, author = {Jit, Mark and Newall, Anthony T. and Beutels, Philippe}, month = {April}, year = {2013}, pmid = {23357859}, pmcid = {PMC3903903}, keywords = {Cost-Benefit Analysis, Humans, Influenza Vaccines, Influenza, Human, Vaccination}, pages = {834--840} }
@article{ subbarao_prospects_2013, title = {The prospects and challenges of universal vaccines for influenza}, volume = {21}, issn = {1878-4380}, doi = {10.1016/j.tim.2013.04.003}, abstract = {Vaccination is the most effective way to reduce the impact of epidemic as well as pandemic influenza. However, the licensed inactivated influenza vaccine induces strain-specific immunity and must be updated annually. When novel viruses appear, matched vaccines are not likely to be available in time for the first wave of a pandemic. Yet, the enormous diversity of influenza A viruses in nature makes it impossible to predict which subtype or strain will cause the next pandemic. Several recent scientific advances have generated renewed enthusiasm and hope for universal vaccines that will induce broad protection from a range of influenza viruses.}, language = {eng}, number = {7}, journal = {Trends in Microbiology}, author = {Subbarao, Kanta and Matsuoka, Yumiko}, month = {July}, year = {2013}, pmid = {23685068}, pmcid = {PMC3700639}, keywords = {Cross Protection, Drug Discovery, Humans, Influenza Vaccines, Influenza, Human}, pages = {350--358} }
@article{ schmidt_quality_2013, title = {Do the quality of the trials and the year of publication affect the efficacy of intervention to improve seasonal influenza vaccination among healthcare workers?: {Results} of a systematic review}, volume = {9}, issn = {2164-554X}, shorttitle = {Do the quality of the trials and the year of publication affect the efficacy of intervention to improve seasonal influenza vaccination among healthcare workers?}, abstract = {INTRODUCTION: Despite longstanding recommendations by public-health authorities vaccination coverage in health care workers worldwide are poor. The aim of this study is to conduct a systematic review of the trials conducted to increase seasonal influenza vaccination rates among health care workers. RESULTS: Ten articles met the pre-determined criteria. For all article the score calculation was performed. DISCUSSION: The combination of an educational and a promotional element appared the most effective in augmenting the influenza vaccination coverage among health care workers. But some cases, the intervention did not contribute to increasing the vaccination rates among health care workers. In any case, the quality of controlled trials plays an important role in the results obtained by carrying out a specific intervention and contributed to obtaining this debatable results. MATERIALS AND METHODS: Research was conducted using Scopus and PubMed database. We selected all clinical trials to perform the meta-analyses.}, language = {eng}, number = {2}, journal = {Human Vaccines \& Immunotherapeutics}, author = {Schmidt, Silvia and Saulle, Rosella and Di Thiene, Domitilla and Boccia, Antonio and La Torre, Giuseppe}, month = {February}, year = {2013}, pmid = {23291943}, pmcid = {PMC3859758}, keywords = {Behavior Therapy, Education, Medical, Guideline Adherence, Health Personnel, Health Promotion, Humans, Influenza Vaccines, Influenza, Human, Vaccination}, pages = {349--361} }
@article{ title = {Reference-free population genomics from next-generation transcriptome data and the vertebrate-invertebrate gap.}, type = {article}, year = {2013}, identifiers = {[object Object]}, keywords = {Animals,Base Sequence,Drosophila,Drosophila: genetics,Genome,Genotype,Hares,Hares: genetics,High-Throughput Nucleotide Sequencing,Human,Humans,Invertebrates,Invertebrates: genetics,Isoptera,Isoptera: genetics,Metagenomics,Ostreidae,Ostreidae: genetics,Polymorphism,Single Nucleotide,Transcriptome,Transcriptome: genetics,Turtles,Turtles: genetics,Urochordata,Urochordata: genetics,Vertebrates,Vertebrates: genetics}, pages = {e1003457}, volume = {9}, websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3623758&tool=pmcentrez&rendertype=abstract}, month = {4}, id = {3639b6ed-7592-301f-8fc7-56d3d09c7c76}, created = {2017-09-18T09:15:16.356Z}, accessed = {2013-08-21}, file_attached = {true}, profile_id = {1c95d708-d42d-399e-b365-9d34fead1a19}, last_modified = {2017-09-18T09:21:29.525Z}, read = {true}, starred = {false}, authored = {true}, confirmed = {true}, hidden = {false}, citation_key = {Gayral2013}, source_type = {article}, notes = { <m:bold>From Duplicate 2 ( </m:bold> <m:bold> <m:italic>Reference-free population genomics from next-generation transcriptome data and the vertebrate-invertebrate gap.</m:italic> </m:bold> <m:bold> - Gayral, Philippe; Melo-Ferreira, José; Glémin, Sylvain; Bierne, Nicolas; Carneiro, Miguel; Nabholz, Benoit; Lourenco, Joao M; Alves, Paulo C; Ballenghien, Marion; Faivre, Nicolas; Belkhir, Khalid; Cahais, Vincent; Loire, Etienne; Bernard, Aurélien; Galtier, Nicolas )<m:linebreak></m:linebreak> </m:bold> <m:linebreak></m:linebreak> <m:linebreak></m:linebreak> <m:linebreak></m:linebreak> }, abstract = {In animals, the population genomic literature is dominated by two taxa, namely mammals and drosophilids, in which fully sequenced, well-annotated genomes have been available for years. Data from other metazoan phyla are scarce, probably because the vast majority of living species still lack a closely related reference genome. Here we achieve de novo, reference-free population genomic analysis from wild samples in five non-model animal species, based on next-generation sequencing transcriptome data. We introduce a pipe-line for cDNA assembly, read mapping, SNP/genotype calling, and data cleaning, with specific focus on the issue of hidden paralogy detection. In two species for which a reference genome is available, similar results were obtained whether the reference was used or not, demonstrating the robustness of our de novo inferences. The population genomic profile of a hare, a turtle, an oyster, a tunicate, and a termite were found to be intermediate between those of human and Drosophila, indicating that the discordant genomic diversity patterns that have been reported between these two species do not reflect a generalized vertebrate versus invertebrate gap. The genomic average diversity was generally higher in invertebrates than in vertebrates (with the notable exception of termite), in agreement with the notion that population size tends to be larger in the former than in the latter. The non-synonymous to synonymous ratio, however, did not differ significantly between vertebrates and invertebrates, even though it was negatively correlated with genetic diversity within each of the two groups. This study opens promising perspective regarding genome-wide population analyses of non-model organisms and the influence of population size on non-synonymous versus synonymous diversity.}, bibtype = {article}, author = {Gayral, Philippe and Melo-Ferreira, José and Glémin, Sylvain and Bierne, Nicolas and Carneiro, Miguel and Nabholz, Benoit and Lourenco, Joao M and Alves, Paulo C and Ballenghien, Marion and Faivre, Nicolas and Belkhir, Khalid and Cahais, Vincent and Loire, Etienne and Bernard, Aurélien and Galtier, Nicolas}, journal = {PLoS genetics}, number = {4} }
@article{de_oliveira_socio-demographic_2013, title = {Socio-demographic factors and oral health conditions in the elderly: {A} population-based study.}, volume = {57}, issn = {0167-4943}, url = {http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=89884612&site=ehost-live}, doi = {10.1016/j.archger.2013.05.004}, abstract = {Abstract: The aim of the present study was to analyze the relationship between oral health conditions and socio-demographic factors in an elderly population from Macaíba/RN (Brazil). A questionnaire was used to characterize the socio-demographic profiles and a clinical examination was performed to assess oral health conditions such as tooth decay, gum disease, use of dental prosthesis, need for dental prosthesis and soft tissue injuries. The technique of random sampling by conglomerates was used, taken from randomly selected census drafts, with a total sample of 441 individuals. The prevalence of edentulism, bleeding and dental calculus was 50.8\%, 27.2\% and 32\%, respectively, excluding all sextants in 59\% of the elderly. Data analysis was conducted using the chi-squared test with the level of significance set at 5\%. Prior to association tests, the dependant variables were submitted to principal component analysis. Four factors were extracted to represent the oral health conditions of elderly individuals. A statistically significant association was found between the following variables: gender and the presence of a caregiver with gum disease; age, residence area, presence of a caregiver and household density with need for dental prosthesis; and household density with soft tissue injuries. Therefore, precarious oral health conditions were found among the elderly and associations were found between these conditions and the socio-demographic factors, particularly gender, age and residence area. The results obtained demonstrated the need for improved oral health conditions in the elderly. The study of these conditions, allied to socio-demographic factors, is important in terms of both dental care and public policy planning related to these individuals.}, number = {3}, journal = {Archives of Gerontology \& Geriatrics}, author = {de Oliveira, Tamires Carneiro and da Silva, Diviane Alves and Leite de Freitas, Yan Nogueira and da Silva, Romerito Lins and Pegado, Carla Patrícia de Castro and de Lima, Kenio Costa}, month = nov, year = {2013}, note = {Publisher: Elsevier B.V.}, keywords = {Age Factors, Aged, Aged, 80 and over, Brazil, Brazil/epidemiology, Census, Chi Square Test, Cross-sectional studies, DMF Index, Educational Status, Elderly, Elderly Oral health and socio-demographic conditions Poverty Sampling studies Cross-sectional studies, Elderly people, Female, Gender, Households, Human, Humans, Male, Middle Aged, Oral Health -- Brazil, Oral Health/*statistics \& numerical data, Oral health, Oral health and socio-demographic conditions, Poverty, Prosthesis, Public Policy -- Brazil, Random Sample, Sampling Studies, Sampling studies, Sex Factors, Sociodemographic aspects, Socioeconomic Factors, Socioeconomic Factors -- Brazil, article}, pages = {389--397}, }
@article{wong_are_2012, title = {Are there socioeconomic disparities in women having discussions on human papillomavirus vaccine with health care providers?}, volume = {12}, issn = {1472-6874}, url = {http://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104306777&site=ehost-live}, doi = {10.1186/1472-6874-12-33}, number = {1}, journal = {BMC Women's Health}, author = {Wong, Ker Yi and Do, Young Kyung}, year = {2012}, keywords = {Adult, Attitude to Health, Cross Sectional Studies, Female, Health Services Accessibility -- Statistics and Numerical Data, Human, Immunization Programs, Middle Age, Papillomavirus Infections -- Prevention and Control, Papillomavirus Vaccine -- Administration and Dosage, Patient Attitudes, Poverty, Professional-Patient Relations, Singapore, Social Class, Socioeconomic Factors, Women's Health, Young Adult}, pages = {33--33}, }
@misc{domingo_j.d._impact_2012, title = {The impact of childhood acute rotavirus gastroenteritis on the parents' quality of life: prospective observational study in {European} primary care medical practices}, url = {http://www.biomedcentral.com/1471-2431/12/58}, abstract = {Background: Rotavirus (RV) is the commonest cause of acute gastroenteritis in infants and young children worldwide. A Quality of Life study was conducted in primary care in three European countries as part of a larger epidemiological study (SPRIK) to investigate the impact of paediatric rotavirus gastroenteritis (RVGE) on affected children and their parents.Methods: A self-administered questionnaire was linguistically validated in Spanish, Italian and Polish. The questionnaire was included in an observational multicentre prospective study of 302 children aged {\textless}5 years presenting to a general practitioner or paediatrician for RVGE at centres in Spain, Italy or Poland. RV infection was confirmed by polymerase chain reaction (PCR) testing (n = 264). The questionnaire was validated and used to assess the emotional impact of paediatric RVGE on the parents.Results: Questionnaire responses showed that acute RVGE in a child adversely affects the parents' daily life as well as the child. Parents of children with RVGE experience worry, distress and impact on their daily activities. RVGE of greater clinical severity (assessed by the Vesikari scale) was associated with higher parental worries due to symptoms and greater changes in the child's behaviour, and a trend to higher impact on parents' daily activities and higher parental distress, together with a higher score on the symptom severity scale of the questionnaire.Conclusions: Parents of a child with acute RVGE presenting to primary care experience worry, distress and disruptions to daily life as a result of the child's illness. Prevention of this disease through prophylactic vaccination will improve the daily lives of parents and children. 2012 Diez-Domingo et al.; licensee BioMed Central Ltd.}, journal = {BMC Pediatrics}, author = {{Domingo J.D.} and {Patrzalek M.} and {Cantarutti L.} and {Arnould B.} and {Meunier J.} and {Soriano-Gabarro M.} and {Meyer N.} and {Pircon J.-Y.} and {Holl K.}}, year = {2012}, keywords = {*Rotavirus infection/dm [Disease Management], *acute gastroenteritis/dm [Disease Management], *childhood disease/dm [Disease Management], *viral gastroenteritis/dm [Disease Management], Child, Female, Infant, Male, article, daily life activity, disease severity, human, major clinical study, medical practice, parent, parental stress, polymerase chain reaction, preschool child, primary medical care, quality of life, questionnaire, scoring system}, }
@article{hsu_comparison_2012, title = {Comparison of neutralizing antibody and cell-mediated immune responses to pandemic {H1N1} 2009 influenza virus before and after {H1N1} 2009 influenza vaccination of elderly subjects and healthcare workers}, volume = {16}, issn = {1201-9712 1878-3511}, url = {http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed13&NEWS=N&AN=52061773}, doi = {10.1016/j.ijid.2012.04.010}, abstract = {Background: The recent H1N1 pandemic virus that emerged in 2009 resulted in high morbidity rates mainly in younger individuals, albeit with relatively low mortality. We investigated both humoral and cellular immune responses against the pandemic H1N1 2009 virus before and after immunization with inactivated H1N1 2009 vaccine. Method(s): We obtained paired blood specimens from a cohort of participants from nursing homes (n=108) and a public hospital (n=60) in Singapore. Serum samples were tested for neutralizing antibodies against H1N1 2009 using microneutralization assays, while peripheral blood mononuclear cells were subjected to interferon-gamma enzyme-linked immunosorbent spot (ELISPOT) assays for whole virus-specific T-cell responses. Result(s): We observed significant increases in geometric mean titers of neutralizing antibodies after H1N1 2009 vaccination (from 23.6 pre-vaccination to 94.7 post-vaccination). Approximately 77\% and 54\% of the cohort exhibited {\textgreater}=2-fold and {\textgreater}=4-fold increases in neutralizing antibody titers following vaccination; 89.9\% of the cohort had a post-vaccination antibody titer of {\textgreater}=32. Adjusted for gender, participants aged {\textgreater}=60 years were less likely to have a {\textgreater}=4-fold increase in antibody titers after vaccination than those aged {\textless}60 years (0.48; 95\% confidence interval (95\% CI) 0.32-0.71, p=0.007). There was a 1.4-fold elevation in H1N1 2009-specific T-cell responses after vaccination (p{\textless}0.05). Adjusted for gender, age {\textgreater}=60 years was positively associated with a greater increase in T-cell response (beta=4.9, 95\% CI 1.58-8.29, p=0.018). No significant correlation was observed between humoral and cellular immune responses. Conclusion(s): Influenza vaccination elicits significant neutralizing antibody and T-cell responses to pandemic H1N1 2009 influenza virus. However, in response to vaccination, increases in neutralizing antibody titers were comparatively lower but T-cell responses were higher in older participants. Therefore, our study suggests that memory T-cells may play a crucial role in protecting older individuals against pandemic H1N1 2009 infection. © 2012 International Society for Infectious Diseases.}, language = {English}, number = {8}, journal = {International Journal of Infectious Diseases}, author = {Hsu, J. P. and Phoon, M. C. and Koh, G. C. H. and Chen, M. I. C. and Lee, V. J. and Wu, Y. and Xie, M. L. and Cheong, A. and Leo, Y. S. and Chow, V. T. K.}, year = {2012}, keywords = {*2009 H1N1 influenza/dt [Drug Therapy], *2009 H1N1 influenza/et [Etiology], *2009 H1N1 influenza/pc [Prevention], *influenza vaccine/dt [Drug Therapy], *influenza vaccine/pd [Pharmacology], *neutralizing antibody/ec [Endogenous Compound], 2009 H1N1 influenza/dt [Drug Therapy], Influenza virus A H1N1, Singapore, adult, aged, aging, animal cell, antibody titer, article, cell strain, cellular immunity, controlled study, enzyme linked immunospot assay, female, health care personnel, human, human cell, humoral immunity, influenza vaccination, major clinical study, male, memory T lymphocyte, morbidity, nonhuman, pandemic influenza, peripheral blood mononuclear cell, sex difference}, pages = {e621--e627}, }
@misc{carlo_w.a._neurodevelopmental_2012, title = {Neurodevelopmental outcomes in infants requiring resuscitation in developing countries}, abstract = {OBJECTIVE: To determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment., STUDY DESIGN: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported., RESULTS: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index {\textless}85 on the Bayley Scales of Infant Development-II (primary outcome; 18\% versus 12\%; P = .22) and in other neurodevelopmental outcomes., CONCLUSIONS: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments. Copyright © 2012 Mosby, Inc. All rights reserved.}, journal = {The Journal of pediatrics}, author = {{Carlo W.A.} and {Goudar S.S.} and {Pasha O.} and {Chomba E.} and {McClure E.M.} and {Biasini F.J.} and {Wallander J.L.} and {Thorsten V.} and {Chakraborty H.} and {Wright L.L.}}, year = {2012}, keywords = {*adverse effects, *procedures, Developmental Disabilities/di [Diagnosis], Developmental Disabilities/ep [Epidemiology], India, Learning Disorders/di [Diagnosis], Learning Disorders/ep [Epidemiology], Mental Disorders/di [Diagnosis], Mental Disorders/ep [Epidemiology], Pakistan, Respiratory Distress Syndrome, Newborn/th [Therapy], Zambia, child development, clinical trial, comparative study, controlled study, developing country, female, human, incidence, infant, male, multicenter study, neuropsychological test, newborn, physiology, prematurity, randomized controlled trial, reference value, resuscitation, risk assessment, rural population, severity of illness index, survival analysis, very low birth weight} }
@misc{tu_h.a.t._health_2012, title = {Health economics of rotavirus immunization in {Vietnam}: {Potentials} for favorable cost-effectiveness in developing countries}, abstract = {Introduction: Rotavirus is the most common cause of severe diarrhoea worldwide. Vietnam is situated in the region of high rotavirus infection incidence and eligible for financial support to introduce rotavirus vaccines into the Expanded Program of Immunization (EPI) from the GAVI. This study was designed to assess the cost-effectiveness of rotavirus immunization in Vietnam, explicitly the use of Rotateq and to assess the affordability of implementing universal rotavirus immunization based on GAVI-subsidized vaccine price in the context of Vietnamese healthcare system for the next 5 years. Methodology: An age-structured cohort model was developed for the 2009 birth cohort in Vietnam. Two strategies were compared: one being the current situation without vaccination, and the other being mass universal rotavirus vaccination. The time horizon of the model was 5 years with time cycles of 1 month for children less than 1 year of age and annual analysis thereafter. Outcomes included mild, moderate, severe cases and death. Multiple outcomes per rotavirus infection are possible in the model. Monte Carlo simulations were used to examine the acceptability and affordability of the rotavirus vaccination. All costs were expressed in 2009 US\$. Results: Rotavirus vaccination would not completely protect young children against rotavirus infection due to partial nature of vaccine immunity, however, would effectively reduce severe cases of rotavirus by roughly 55\% during the first 5 years of life. Under GAVI-subsidized vaccine price (US\$ 0.3/dose), the vaccine cost would amount to US\$ 5.5 million per annum for 3-dose of the Rotateq vaccine. In the base-case, the incremental cost per quality-adjusted-life-year (QALY) was US\$ 665 from the health system perspective, much lower than per-capita GDP of {\textasciitilde}US\$ 1150 in 2009. Affordability results showed that at the GAVI-subsidized vaccine price, rotavirus vaccination could be affordable for Vietnamese health system. Conclusion: Rotavirus vaccination in Vietnam would be a cost-effective health intervention. Vaccination only becomes affordable if the country receives GAVI's financial support due to the current high market vaccine price. Given the high mortality rate of under-five-year children, the results showed that rotavirus immunization is the " best hope" for prevention of rotavirus-related diarrhoeal disease in Vietnam. In the next five years, Vietnam is definitely in debt to financial support from international organizations in implementing rotavirus immunization. It is recommended that new rotavirus vaccine candidates be developed at cheaper price to speed up the introduction of rotavirus immunization in the developing world in general. 2011 Elsevier Ltd.}, journal = {Vaccine}, author = {{Tu H.A.T.} and {Rozenbaum M.H.} and {Coyte P.C.} and {Li S.C.} and {Woerdenbag H.J.} and {Postma M.J.}}, year = {2012}, keywords = {*Rotavirus infection/dm [Disease Management], *Rotavirus infection/dt [Drug Therapy], *Rotavirus infection/pc [Prevention], *Rotavirus vaccine/dt [Drug Therapy], *Rotavirus vaccine/pe [Pharmacoeconomics], *drug cost, Child, Infant, Monte Carlo method, Vaccination, Viet Nam, article, cost effectiveness analysis, drug efficacy, health care system, health economics, human, major clinical study, mortality, preschool child, priority journal, quality of life}, }
@inProceedings{ id = {a6b630ec-5c73-3f94-95b6-8a2d0b39d6a3}, title = {Do Different Hint Techniques Embedded in a Digital Game-Based Learning Tool have an effect on students ’ behavior ?}, type = {inProceedings}, year = {2011}, keywords = {computer interaction,digital game based learning,education,human,learn to play and,mental thinking,periodic table of,play to learn}, created = {2013-03-26T11:06:32.000Z}, file_attached = {true}, profile_id = {e7747f90-d244-30f0-8ab8-040e1ce7fcca}, group_id = {eb547711-a9bc-34f4-87c4-f439162c9d1c}, last_modified = {2014-10-22T17:07:45.000Z}, read = {true}, starred = {false}, authored = {false}, confirmed = {false}, hidden = {false}, bibtype = {inProceedings}, author = {Hjert-bernardi, Kiira and Hernández-leo, Davinia and Melero, Javier and Blat, Josep}, booktitle = {Workshop Ambient Games on International Joint Conference on Ambient Intelligence} }
@incollection{tinwell_uncanny_2011, address = {Hershey PA}, title = {Uncanny {Speech}}, booktitle = {Game {Sound} {Technology} and {Player} {Interaction}: {Concepts} and {Developments}}, publisher = {IGI Global}, author = {Tinwell, Angela and Grimshaw, Mark and Williams, Andrew}, editor = {Grimshaw, Mark}, year = {2011}, keywords = {cross-modality, facial expression, fidelity, human, lip-synch, speech, uncanniness, uncanny valley}, pages = {213--234}, }
@article{ mcelhaney_influenza_2011, title = {Influenza vaccine responses in older adults}, volume = {10}, issn = {1872-9649}, doi = {10.1016/j.arr.2010.10.008}, abstract = {The most profound consequences of immune senescence with respect to public health are the increased susceptibility to influenza and loss of efficacy of the current split-virus influenza vaccines in older adults, which are otherwise very effective in younger populations. Influenza infection is associated with high rates of complicated illness including pneumonia, heart attacks and strokes in the 65+ population. Changes in both innate and adaptive immune function not only converge in the reduced response to vaccination and protection against influenza, but present significant challenges to new vaccine development. In older adults, the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity. Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy. Further, antibody responses to vaccination as a correlate of protection may fail to detect important changes in cellular immunity and enhanced vaccine-mediated protection against influenza illness in older people. This article will discuss the impact of influenza in older adults, immunologic targets for improved efficacy of the vaccines, and alternative correlates of clinical protection against influenza that are needed for more effective translation of novel vaccination strategies to improved protection against influenza in older adults.}, language = {eng}, number = {3}, journal = {Ageing Research Reviews}, author = {McElhaney, Janet E.}, month = {July}, year = {2011}, pmid = {21055484}, pmcid = {PMC3061971}, keywords = {Adaptive Immunity, Aged, Aged, 80 and over, Aging, Humans, Immunity, Innate, Influenza Vaccines, Influenza, Human, T-Lymphocytes, Treatment Outcome}, pages = {379--388} }
@article{birrell_bayesian_2011, title = {Bayesian modeling to unmask and predict influenza {A}/{H}1N1pdm dynamics in {London}}, volume = {108}, issn = {1091-6490}, doi = {10.1073/pnas.1103002108}, abstract = {The tracking and projection of emerging epidemics is hindered by the disconnect between apparent epidemic dynamics, discernible from noisy and incomplete surveillance data, and the underlying, imperfectly observed, system. Behavior changes compound this, altering both true dynamics and reporting patterns, particularly for diseases with nonspecific symptoms, such as influenza. We disentangle these effects to unravel the hidden dynamics of the 2009 influenza A/H1N1pdm pandemic in London, where surveillance suggests an unusual dominant peak in the summer. We embed an age-structured model into a bayesian synthesis of multiple evidence sources to reveal substantial changes in contact patterns and health-seeking behavior throughout the epidemic, uncovering two similar infection waves, despite large differences in the reported levels of disease. We show how this approach, which allows for real-time learning about model parameters as the epidemic progresses, is also able to provide a sequence of nested projections that are capable of accurately reflecting the epidemic evolution.}, language = {eng}, number = {45}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, author = {Birrell, Paul J. and Ketsetzis, Georgios and Gay, Nigel J. and Cooper, Ben S. and Presanis, Anne M. and Harris, Ross J. and Charlett, André and Zhang, Xu-Sheng and White, Peter J. and Pebody, Richard G. and De Angelis, Daniela}, month = nov, year = {2011}, pmid = {22042838}, pmcid = {PMC3215054}, keywords = {Bayes Theorem, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, London}, pages = {18238--18243} }
@article{pentland_key_2011, title = {Key characteristics of knowledge transfer and exchange in healthcare: integrative literature review}, volume = {67}, issn = {1365-2648}, shorttitle = {Key characteristics of knowledge transfer and exchange in healthcare}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2648.2011.05631.x}, doi = {10/bbmtr4}, language = {en}, number = {7}, urldate = {2019-01-13}, journal = {Journal of Advanced Nursing}, author = {Pentland, Duncan and Forsyth, Kirsty and Maciver, Donald and Walsh, Mike and Murray, Richard and Irvine, Linda and Sikora, Simon}, year = {2011}, keywords = {\#à lire 📖}, pages = {1408--1425} }
@article{schroeder_neonatal_2011, title = {Neonatal {DNA} methylation patterns associate with gestational age.}, volume = {6}, issn = {1559-2308}, url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3256334&tool=pmcentrez&rendertype=abstract}, doi = {10.4161/epi.6.12.18296}, abstract = {Risk for adverse neonatal outcome increases with declining gestational age (GA), and changes in DNA methylation may contribute to the relationship between GA and adverse health outcomes in offspring. To test this hypothesis, we evaluated the association between GA and more than 27,000 CpG sites in neonatal DNA extracted from umbilical cord blood from two prospectively-characterized cohorts: (1) a discovery cohort consisting of 259 neonates from women with a history of neuropsychiatric disorders and (2) a replication cohort consisting of 194 neonates of uncomplicated mothers. GA was determined by obstetrician report and maternal last menstrual period. The associations between proportion of DNA methylated and GA were evaluated by fitting a separate linear mixed effects model for each CpG site, adjusting for relevant covariates including neonatal sex, race, parity, birth weight percentile and chip effects. CpG sites in 39 genes were associated with GA (false discovery rate {\textless} 0.05) in the discovery cohort. The same CpG sites in 25 of these genes replicated in the replication cohort, with each association replicating in the same direction. Notably, these CpG sites were located in genes previously implicated in labor and delivery (e.g., AVP, OXT, CRHBP and ESR1) or that may influence the risk for adverse health outcomes later in life (e.g., DUOX2, TMEM176A and CASP8). All associations were independent of method of delivery or induction of labor. These results suggest neonatal DNA methylation varies with GA even in term deliveries. The potential contribution of these changes to clinically significant postnatal outcomes warrants further investigation.}, number = {12}, urldate = {2015-05-26}, journal = {Epigenetics : official journal of the DNA Methylation Society}, author = {Schroeder, James W and Conneely, Karen N and Cubells, Joseph C and Kilaru, Varun and Newport, D Jeffrey and Knight, Bettina T and Stowe, Zachary N and Brennan, Patricia A and Krushkal, Julia and Tylavsky, Frances A and Taylor, Robert N and Adkins, Ronald M and Smith, Alicia K}, month = dec, year = {2011}, pmid = {22139580}, keywords = {Birth Weight, Birth Weight: genetics, Cohort Studies, CpG Islands, CpG Islands: genetics, DNA Methylation, DNA Methylation: genetics, Female, Fetal Blood, Fetal Blood: metabolism, Genome, Human, Gestational Age, Humans, Infant, Newborn, Male, Pregnancy, Pregnancy Outcome}, pages = {1498--504}, }
@article{win_influenza_2010, title = {Influenza {B} {Outbreak} among influenza-vaccinated welfare home residents in {Singapore}}, volume = {39}, issn = {0304-4602}, url = {http://www.annals.edu.sg/pdf/39VolNo6Jun2010/V39N6p448.pdf http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed11&NEWS=N&AN=359159306}, abstract = {Introduction: Outbreaks of acute respiratory illness occur commonly in long-term care facilities (LTCF), due to the close proximity of residents. Most influenza outbreak reports have been from temperate countries. This study reports an outbreak of infl uenza B among a highly immunised resident population in a welfare home in tropical Singapore, and discusses vaccine effi cacy and the role of acute respiratory illness surveillance for outbreak prevention and control. Material(s) and Method(s): During the period from 16 to 21 March 2007, outbreak investigations and active case fi nding were carried out among residents and nursing staff at the welfare home. Interviews and medical notes review were conducted to obtain epidemiological and clinical data. Hospitalised patients were tested for respiratory pathogens. Further genetic studies were also carried out on positive respiratory samples. Result(s): The overall clinical attack rate was 9.4\% (17/180) in residents and 6.7\% (2/30) in staff. All infected residents and staff had received infl uenza immunisation. Fifteen residents were hospitalised, with 2 developing severe complications. Genetic sequencing revealed that the outbreak strain had an 8.2\% amino acid difference from B/Malaysia/2506/2004, the 2006 southern hemisphere infl uenza vaccine strain, which the residents and staff had earlier received. Conclusion(s): A mismatch between the vaccine and circulating infl uenza virus strains can result in an outbreak in a highly immunised LTCF resident population. Active surveillance for acute respiratory illness in LTCFs could be implemented for rapid detection of antigenic drift. Enhanced infection control and other preventive measures can then be deployed in a timely manner to mitigate the effect of any outbreaks.}, language = {English}, number = {6}, journal = {Annals of the Academy of Medicine Singapore}, author = {Win, M. K. and Chow, A. and Chen, M. and Lau, Y. F. and Ooi, E. E. and Leo, Y. S.}, year = {2010}, keywords = {*influenza B/dt [Drug Therapy], *influenza B/pc [Prevention], *influenza vaccination, *influenza vaccine/dt [Drug Therapy], Singapore, adult, aged, article, case finding, clinical article, clinical feature, controlled study, disease severity, disease surveillance, drug efficacy, epidemic, gene sequence, hospitalization, human, infection control, influenza B/dt [Drug Therapy], polymerase chain reaction, residential home, strain difference, thorax radiography, virus strain}, pages = {448--452}, }
@book{sudbery_human_2010, address = {London ; New York}, series = {Student social work}, title = {Human growth and development: an introduction for social workers}, isbn = {978-0-415-43994-7 978-0-415-43995-4 978-0-203-87194-2}, shorttitle = {Human growth and development}, publisher = {Routledge}, author = {Sudbery, John}, year = {2010}, note = {OCLC: ocn312444673}, keywords = {Developmental psychobiology, Human growth, Life cycle, Human, Social service}, }
@misc{oryan_m._update_2009, title = {Update on {Rotarix}: {An} oral human rotavirus vaccine}, abstract = {Worldwide, rotaviruses are the single most important agents of severe gastroenteritis in infants and young children. Globally, it is estimated that every year rotavirus gastroenteritis causes more than 125 million episodes of diarrhea and nearly 527,000 deaths, mainly in developing countries. The development of new effective and safe rotavirus vaccines was recognized as the most effective intervention strategy that could yield a significant impact on the burden of rotavirus disease. Rotarix is an oral live-attenuated human rotavirus vaccine containing a single G1P[8] strain. The first oral dose may be administered as early as 6 weeks of age, with a minimum interval of 4 weeks prior to second dose; the vaccination course should be completed by the age of 24 weeks according to the manufacturer. In the USA, the upper age limit for the second dose has recently been recommended at 32 weeks of age by the Advisory Committee on Immunization Practices. The development program for Rotarix including Phase I, II and III multicenter studies involving over 100,000 infants has been established in Latin America, Europe, Asia and Africa. The vaccine proved to be well tolerated, immunogenic, efficacious, safe and not associated with intussusception. It provided 85-96\% protection against severe rotavirus gastroenteritis caused by G1 and non-G1 serotypes in Latin American and European clinical trials; and of public health importance, Rotarix reduced hospitalizations of all-cause gastroenteritis by 40 and 75\%, respectively. Efficacy against G2P[4] strains ranged from 41\% in Latin America to 81\% in Europe. In the former, Rotarix afforded sustained high protection (80.5\%; 95\% CI: 71.3-87.1) against severe rotavirus gastroenteritis during the first 2 years of life in a region with a changing pattern of wild-type rotavirus circulation. In a recently completed vaccine trial in South Africa and Malawi, Rotarix showed an overall efficacy of 61.2\% (95\% CI: 44.0-73.2) by 1 year of age. Although these rates are lower than those from developed and middle-income countries, they look promising given the lack of other effective interventions. With the expanding introduction of rotavirus vaccines into national immunization programs, postmarketing surveillance should be conducted to measure the impact of rotavirus vaccination, as well as continued monitoring of circulating rotavirus strains. 2009 Expert Reviews Ltd.}, journal = {Expert Review of Vaccines}, author = {{O'Ryan M.} and {Linhares A.C.}}, year = {2009}, keywords = {*Gastroenteritis/ep [Epidemiology], *Rotavirus vaccine/ad [Drug Administration], *Rotavirus vaccine/ct [Clinical Trial], *Rotavirus vaccine/do [Drug Dose], *Rotavirus vaccine/dt [Drug Therapy], *Rotavirus vaccine/dv [Drug Development], *Rotavirus vaccine/pd [Pharmacology], *Rotavirus vaccine/po [Oral Drug Administration], *gastroenteritis/dt [Drug Therapy], *gastroenteritis/pc [Prevention], *vaccination, Africa, Asia, Clinical trial, Diarrhea, Europe, Hospitalization, Human rotavirus, Immunogenicity, Intussusception, Malawi, Malnutrition, Serotype, South Africa, South and Central America, United States, advisory committee, death, developing country, drug cost, drug efficacy, drug industry, drug safety, drug tolerability, health program, human, immunization, multicenter study, nonhuman, placebo, postmarketing surveillance, prematurity, preventive health service, priority journal, protection, quality of life, recommended drug dose, review, virus infection/dt [Drug Therapy], virus strain, wild type}, }
@article{ title = {A stressor-independent test for biodiversity – ecosystem function relationships during a 23-year whole-lake experiment}, type = {article}, year = {2009}, identifiers = {[object Object]}, pages = {1903-1909}, volume = {66}, id = {9c690c6c-6704-3425-aed4-a218c69deab7}, created = {2019-07-12T15:07:48.375Z}, file_attached = {true}, profile_id = {3c181434-ae75-3e95-a723-2bfcc2f14c0b}, group_id = {db3318bf-b2fb-3b86-9f1d-17188c0ddfa3}, last_modified = {2019-07-24T17:15:23.073Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Vinebrooke2009a}, private_publication = {false}, abstract = {Abstract: Anthropogenic stressors are the current drivers of loss of global biodiversity and deterioration of ecosystem function (e.g., primary production). However, it is debatable whether human stressors or associated changes in biodiversity better predict the impairment of ecosystem function. Variation in plankton communities during a whole-lake experiment (Lake 302S, Experimental Lakes Area, Canada) was examined to test whether the stressor treatment effect or subsequent stressor-independent variation in species richness best explained interannual variation in aggregate functional properties, such as productivity or net total biomass. Although significant ‘‘biodiversity – ecosystem function’’ relationships were de- tected, these correlations were confounded by the negative effect of experimental acidification on species richness. The stressor effect was removed by plotting functional properties against the residuals from the species richness – pH regres- sions, which generated either negative or nonsignificant relationships. The lack of significant stressor-independent positive relationships between functional properties and species richness highlights the potential greater importance of other media- ting factors, such as interactions among multiple stressors, species identity, and altered trophic interactions, at the whole- ecosystem scale. Re ´sume ´ : Les stress anthropiques sont les causes courantes de la perte de la biodiversite ´ globale et de la de ´rioration du ´te fonctionnement des e ´cosyste `mes (par ex., de la production primaire). Il n’est pas clair, cependant, si ce sont les facteurs anthropiques de stress ou les changements de biodiversite ´ qui leur sont associe ´s qui pre ´disent le mieux la de ´rioration du ´te fonctionnement des e ´cosyste `mes. Nous avons examine ´ la variation des communaute ´s de plancton dans une expe ´rience a ` l’e ´chelle d’un lac entier (lac 302S, Re ´gion des lacs expe ´rimentaux, Canada) afin de ve ´rifier si la variation interannuelle des proprie ´s fonctionnelles globales, telles que la productivite ´te ´ ou la biomasse totale nette, s’expliquent mieux par les ef- fets du traitement de stress ou par la variation subse ´quente de la richesse spe ´cifique qui est inde ´pendante du facteur de stress. Bien que des relations significatives « biodiversite ´ – fonction e ´cosyste ´mique » puissent e ˆtre de ´cele ´es, ces corre ´lations sont obscurcies par l’effet ne ´gatif de l’acidification expe ´rimentale sur la richesse spe ´cifique. L’effet du facteur de stress est retire ´ en repre ´sentant sur un graphique les proprie ´s fonctionnelles en fonction des re ´te ´sidus des re ´gressions de la ri- chesse spe ´cifique sur le pH, ce qui ge `re des relations ne ´ne ´gatives ou alors non significatives. L’absence de relations posi- tives significatives inde ´pendantes du facteur de stress entre les proprie ´s fonctionnelles et la richesse spe ´te ´cifique souligne l’importance potentiellement supe ´rieure d’autres facteurs explicatifs, tels que les interactions entre les multiples facteurs de stress, l’identite ´ des espe `ces et l’alte ´ration des relations trophiques a ` l’e ´chelle de l’e ´cosyste `me entier. [Traduit par la Re ´daction] Introduction}, bibtype = {article}, author = {Vinebrooke, R. D. and Turner, M. A. and Findlay, D. L. and Paterson, M. J.}, journal = {Canadian Journal of Fisheries and Aquatic Sciences}, number = {11}, keywords = {ACIDIFICATION,BIODIVERSITY,ELA,HUMAN,L302S,Multiple stressors,PH,PHYTOPLANKTON,PRIMARY PRODUCTION,SCALE,SPECIES DIVERSITY,Whole-lake manipulation,ZOOPLANKTON} }
@article{ title = {Rapid prototyping of microfluidic devices with a wax printer.}, type = {article}, year = {2007}, identifiers = {[object Object]}, keywords = {Humans,Immunohistochemistry,Mammary Glands, Human,Mammary Glands, Human: cytology,Microfluidics,Microfluidics: instrumentation}, pages = {384-7}, volume = {7}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/17330171}, month = {3}, id = {9b46b840-7d64-3402-8cd7-aa51f24a09a8}, created = {2016-06-24T20:49:45.000Z}, accessed = {2014-05-10}, file_attached = {false}, profile_id = {954a987f-819f-3985-95a4-2991e0cf0552}, group_id = {8440dcff-74cc-3783-aef7-fe2749cfc7ef}, last_modified = {2016-06-24T20:49:45.000Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Kaigala2007}, abstract = {We demonstrate a rapid and inexpensive approach for the fabrication of high resolution poly(dimethylsiloxane) (PDMS)-based microfluidic devices. The complete process of fabrication could be performed in several hours (or less) without any specialized equipment other than a consumer-grade wax printer. The channels produced by this method are of high enough quality that we are able to demonstrate the sizing and separation of DNA fragments using capillary electrophoresis (CE) with no apparent loss of resolution over that found with glass chips fabricated by conventional photolithographic methods. We believe that this method will greatly improve the accessibility of rapid prototyping methods.}, bibtype = {article}, author = {Kaigala, Govind V and Ho, Sunny and Penterman, Roel and Backhouse, Christopher J}, journal = {Lab on a chip}, number = {3} }
@article{hippisley-cox_qflu:_2006, title = {{QFLU}: new influenza monitoring in {UK} primary care to support pandemic influenza planning}, volume = {11}, issn = {1560-7917}, shorttitle = {{QFLU}}, language = {eng}, number = {6}, journal = {Euro Surveillance: Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin}, author = {Hippisley-Cox, J. and Smith, S. and Smith, G. and Porter, A. and Heaps, M. and Holland, R. and Fenty, J. and Harcourt, S. and George, R. and Charlett, A. and Pebody, R. G. and Painter, M.}, year = {2006}, pmid = {16819130}, keywords = {Communicable Disease Control, Disease Notification, Disease Outbreaks, Family Practice, Great Britain, Health Planning, Humans, Influenza, Human, Population Surveillance, Primary Health Care, Risk Assessment, Risk Factors, incidence}, pages = {E060622.4} }
@article{ title = {The knowledge-value chain: A conceptual framework for knowledge translation in health}, type = {article}, year = {2006}, identifiers = {[object Object]}, keywords = {Biomedical Research,Humans,Information Dissemination,Information Systems,Public Health Administration,conceptual framework,education policy,evidence based medicine,health care organization,health care policy,health practitioner,health program,health service,human,human relation,knowledge,learning,medical literature,medical practice,medical research,professional knowledge,public health,review,systematic review,world health organization}, pages = {597-602}, volume = {84}, websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33748346673&partnerID=40&md5=07c2c903c1ddffd98d455121833cb07e}, city = {Affiliation: Department of Management, Faculty of Business, Laval University, Québec City, Que. G1K 7P4, Canada; Affiliation: Department of Knowledge Management and Sharing, World Health Organization, 1211 Geneva 27, Switzerland; Affiliation: Canadian Hea}, id = {db3b79d4-cc6a-393c-b38b-1e9fdae127d4}, created = {2016-08-21T22:17:40.000Z}, file_attached = {false}, profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597}, group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4}, last_modified = {2017-03-14T09:54:45.334Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {JOUR}, notes = {Cited By (since 1996): 34}, folder_uuids = {028056a6-dab5-46a4-b9bf-02542e7cfa2b}, private_publication = {false}, abstract = {This article briefly discusses knowledge translation and lists the problems associated with it. Then it uses knowledge-management literature to develop and propose a knowledge-value chain framework in order to provide an integrated conceptual model of knowledge management and application in public health organizations. The knowledge-value chain is a non-linear concept and is based on the management of five dyadic capabilities: mapping and acquisition, creation and destruction, integration and sharing/transfer, replication and protection, and performance and innovation.}, bibtype = {article}, author = {Landry, R and Amara, N and Pablos-Mendes, A and Shademani, R and Gold, I}, journal = {Bulletin of the World Health Organization}, number = {8} }
@article{lee_influenza_2006, title = {Influenza and the pandemic threat}, volume = {47}, issn = {0037-5675}, url = {http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed9&NEWS=N&AN=43900491}, abstract = {With the increasing concern of an imminent influenza pandemic, Singapore and many other countries have been developing preparedness plans. Influenza affects an estimated 20 percent of the population of Singapore annually, and local outbreaks can last for more than 12 weeks and occur at different periods of the year. The 1968 pandemic in Singapore had a clinical attack rate of about 20 percent and resulted in infections with fever that lasted up to five days. However, absenteeism from work due to seasonal influenza-like illnesses was estimated to be less than one day per person in Singapore. The next pandemic in Singapore is predicted to cause an average of 1,105 deaths and 3,338 hospitalisations, while a severe pandemic will cause more healthcare damage. Preventive strategies include national public health initiatives, vaccination, anti-viral therapy, and hygiene measures. To develop effective preparedness plans, it is important for healthcare workers to understand the disease's epidemiology, outcomes, and treatment and prevention strategies available.}, language = {English}, number = {6}, journal = {Singapore Medical Journal}, author = {Lee, V. J. and Fernandez, G. G. and Chen, M. I. and Lye, D. and Leo, Y. S.}, year = {2006}, keywords = {*influenza/di [Diagnosis], *influenza/dt [Drug Therapy], *influenza/ep [Epidemiology], *influenza/et [Etiology], *influenza/pc [Prevention], Influenza virus, Singapore, absenteeism, adamantane derivative/dt [Drug Therapy], amantadine/dt [Drug Therapy], clinical feature, diagnostic procedure, epidemic, hospitalization, human, hygiene, infection prevention, influenza vaccine/dt [Drug Therapy], mortality, nonhuman, oseltamivir/ae [Adverse Drug Reaction], oseltamivir/cm [Drug Comparison], oseltamivir/dt [Drug Therapy], pathogenesis, review, rimantadine/dt [Drug Therapy], sialidase inhibitor/dt [Drug Therapy], unspecified side effect/si [Side Effect], vaccination, virology, virus infectivity, withdrawal syndrome/si [Side Effect], zanamivir/ad [Drug Administration], zanamivir/dt [Drug Therapy], zanamivir/ih [Inhalational Drug Administration], zanamivir/pa [Parenteral Drug Administration]}, pages = {463--469}, }
@misc{botha_j.f._small_2006, title = {Small bowel transplantation: {Literature} review 2003-2005}, abstract = {The rapid expansion of the volume of peer reviewed publications in recent years, including a large increase in the number of new biomedical journals, makes it difficult for the practicing clinician to stay up to date with the medical literature. This review is part of a new series that will provide succinct summaries of the recent medical literature in the field of pediatric transplantation. In this review, we summarize important articles in the field of pediatric intestine transplantation that have been published over the last 21/2; years (2003-2005). The review is intended to be comprehensive but not exhaustive. 2005 Blackwell Munksgaard.}, journal = {Pediatric Transplantation}, author = {{Botha J.F.} and {Horslen S.P.}}, year = {2006}, keywords = {*Hirschsprung disease/su [Surgery], *graft rejection/co [Complication], *graft rejection/dt [Drug Therapy], *graft rejection/pc [Prevention], *granzyme B/ec [Endogenous Compound], *immunosuppressive agent/cb [Drug Combination], *immunosuppressive agent/dt [Drug Therapy], *immunosuppressive treatment, *intestine transplantation, *perforin/ec [Endogenous Compound], *short bowel syndrome/su [Surgery], Adenovirus, Adult, Asia, B lymphocyte, Canada, Child, Europe, Incidence, Middle East, OKT 3/cb [Drug Combination], OKT 3/dt [Drug Therapy], South America, T lymphocyte, United States, abdominal wall, aciclovir/cb [Drug Combination], aciclovir/dt [Drug Therapy], aciclovir/po [Oral Drug Administration], acute graft rejection/co [Complication], acute graft rejection/dt [Drug Therapy], age distribution, alemtuzumab/cb [Drug Combination], alemtuzumab/dt [Drug Therapy], apoptosis, azathioprine/cb [Drug Combination], azathioprine/dt [Drug Therapy], basiliximab/cb [Drug Combination], basiliximab/dt [Drug Therapy], blood group ABO system, body weight, chronic graft rejection/co [Complication], chronic graft rejection/dt [Drug Therapy], corticosteroid/cb [Drug Combination], corticosteroid/dt [Drug Therapy], cyclophosphamide/cb [Drug Combination], cyclophosphamide/dt [Drug Therapy], cytomegalovirus infection/co [Complication], cytotoxic T lymphocyte, daclizumab/cb [Drug Combination], daclizumab/dt [Drug Therapy], death, food allergy/co [Complication], ganciclovir/cb [Drug Combination], ganciclovir/dt [Drug Therapy], ganciclovir/iv [Intravenous Drug Administration], graft survival, histopathology, human, ileostomy, immunohistochemistry, immunotherapy, interleukin 2 receptor/ec [Endogenous Compound], intestine biopsy, intestine brush border, irradiation, length of stay, liver transplantation, living donor, microvillus inclusion disease/su [Surgery], mortality, mycophenolic acid 2 morpholinoethyl ester/cb [Drug Combination], mycophenolic acid 2 morpholinoethyl ester/dt [Drug Therapy], natural killer T cell, opportunistic infection/co [Complication], parenteral nutrition, peer review, prognosis, quality of life, rapamycin/cb [Drug Combination], rapamycin/dt [Drug Therapy], review, risk factor, rotavirus, sclerosing peritonitis/co [Complication], survival rate, systematic review, tacrolimus/cb [Drug Combination], tacrolimus/dt [Drug Therapy], thymocyte antibody/cb [Drug Combination], thymocyte antibody/dt [Drug Therapy], transplantation tolerance, twins, vascular disease/co [Complication], vascular disease/dt [Drug Therapy], vascular disease/pc [Prevention], viral gastroenteritis/co [Complication], viral gastroenteritis/dt [Drug Therapy], viral gastroenteritis/et [Etiology], viral gastroenteritis/pc [Prevention]}, }
@article{kinzig_effects_2005-1, title = {The effects of human socioeconomic status and cultural characteristics on urban patterns of biodiversity}, volume = {10}, abstract = {We present evidence that there can be substantial variation in species richness in residential areas differing in their socioeconomic and cultural characteristics. Many analyses of the impacts of urbanization on biodiversity rely on traditional “urban-to-rural}, number = {1}, journal = {Ecology and Society}, author = {Kinzig, A. P. and Warren, P. S. and Martin, C. and Hope, D. and Katti, M.}, year = {2005}, keywords = {BES, biodiversity, urban, social aspects, human} }
@article{chen_over_2004, title = {Over 20\% of human transcripts might form sense-antisense pairs.}, volume = {32}, issn = {1362-4962}, url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=519112&tool=pmcentrez&rendertype=abstract}, doi = {10.1093/nar/gkh818}, abstract = {The major challenge to identifying natural sense- antisense (SA) transcripts from public databases is how to determine the correct orientation for an expressed sequence, especially an expressed sequence tag sequence. In this study, we established a set of very stringent criteria to identify the correct orientation of each human transcript. We used these orientation-reliable transcripts to create 26 741 transcription clusters in the human genome. Our analysis shows that 22\% (5880) of the human transcription clusters form SA pairs, higher than any previous estimates. Our orientation-specific RT-PCR results along with the comparison of experimental data from previous studies confirm that our SA data set is reliable. This study not only demonstrates that our criteria for the prediction of SA transcripts are efficient, but also provides additional convincing data to support the view that antisense transcription is quite pervasive in the human genome. In-depth analyses show that SA transcripts have some significant differences compared with other types of transcripts, with regard to chromosomal distribution and Gene Ontology-annotated categories of physiological roles, functions and spatial localizations of gene products.}, number = {16}, journal = {Nucleic acids research}, author = {Chen, Jianjun and Sun, Miao and Kent, W James and Huang, Xiaoqiu and Xie, Hanqing and Wang, Wenquan and Zhou, Guolin and Shi, Run Zhang and Rowley, Janet D}, month = jan, year = {2004}, pmid = {15356298}, keywords = {Antisense, Antisense: analysis, Antisense: chemistry, Antisense: genetics, Base Pairing, Chromosomes, Genetic, Genome, Human, Humans, Messenger, Messenger: chemistry, RNA, Reverse Transcriptase Polymerase Chain Reaction, Transcription}, pages = {4812--20} }
@article{ title = {Effectiveness and efficiency of guideline dissemination and implementation strategies}, type = {article}, year = {2004}, identifiers = {[object Object]}, keywords = {Cochrane Library,EMBASE,MEDLINE,United Kingdom,clinical practice,clinical research,cost benefit analysis,cost effectiveness analysis,education,epidemiology,feasibility study,health care organization,health care personnel,health care planning,health care policy,health economics,health survey,human,information dissemination,information retrieval,medical audit,medical decision making,practice guideline,primary medical care,register,review}, pages = {iii-72}, volume = {8}, websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-10744224331&partnerID=40&md5=3c257899cd02a20f42bae7e74745d8b2}, city = {Affiliation: Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom; Affiliation: Health Economics Research Unit, University of Aberdeen, Aberdeen, United Kingdom; Affiliation: Dept. of Epidemiology/Public Health, University of Ne}, id = {f9c473fa-9431-320d-9e25-c5cf0ccc5bb0}, created = {2016-08-21T22:17:35.000Z}, file_attached = {false}, profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597}, group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4}, last_modified = {2017-03-14T09:54:45.334Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {JOUR}, notes = {Cited By (since 1996): 851}, folder_uuids = {028056a6-dab5-46a4-b9bf-02542e7cfa2b}, private_publication = {false}, abstract = {Objectives: To undertake a systematic review of the effectiveness and costs of different guideline development, dissemination and implementation strategies. To estimate the resource implications of these strategies. To develop a framework for deciding when it is efficient to develop anal introduce clinical guidelines. Data sources: Medline, Healthstar, Cochrane Controlled Trial Register, EMBASE, SIGLE and the specialised register of the Cochrane Effective Practice and Organisation of Care (EPOC) group. Review methods: Single estimates of dichotomous process variables were derived for each study comparison based upon the primary end-point or the median measure across several reported end-points. Separate analyses were undertaken for comparisons of different types of intervention. The study also explored whether the effects of multifaceted interventions increased with the number of intervention components. Studies reporting economic data were also critically appraised. A survey to estimate the feasibility and likely resource requirements of guideline dissemination and implementation strategies in UK settings was carried out with key informants from primary and secondary care. Results: In total, 235 studies reporting 309 comparisons met the inclusion criteria; of these 73% of comparisons evaluated multifaceted interventions, although the maximum number of replications of a specific multifaceted intervention was 11 comparisons. Overall, the majority of comparisons reporting dichotomous process data observed improvements in care; however, there was considerable variation in the observed effects both within and across interventions. Commonly evaluated single interventions were reminders, dissemination of educational materials, and audit and feedback. There were 23 comparisons of multifaceted interventions involving educational outreach. The majority of interventions observed modest to moderate improvements in care. No relationship was found between the number of component interventions and the effects of multifaceted interventions. Only 29.4% of comparisons reported any economic data. The majority of studies only reported costs of treatment; only 25 studies reported data on the costs of guideline development or guideline dissemination and implementation. The majority of studies used process measures for their primary end-point, despite the fact that only three guidelines were explicitly evidence based (and may not have been efficient). Respondents to the key informant survey rarely identified existing budgets to support guideline dissemination and implementation strategies. In general, the respondents thought that only dissemination of educational materials and short (lunchtime) educational meetings were generally feasible within current resources. Conclusions: There is an imperfect evidence base to support decisions about which guideline dissemination and implementation strategies are likely to be efficient under different circumstances. Decision makers need to use considerable judgement about how best to use the limited resources they have for clinical governance and related activities to maximise population benefits. They need to consider the potential clinical areas for clinical effectiveness activities, the likely benefits and costs required to introduce guidelines and the likely benefits and costs as a result of any changes in provider behaviour. Further research is required to: develop and validate a coherent theoretical framework of health professional and organisational behaviour and behaviour change to inform better the choice of interventions in research and service settings, and to estimate the efficiency of dissemination and implementation strategies in the presence of different barriers and effect modifiers. © Queen's Printer and Controller of HMSO 2004. All rights reserved.}, bibtype = {article}, author = {Grimshaw, J M and Thomas, R E and MacLennan, G and Fraser, C and Ramsay, C R and Vale, L and Whitty, P and Eccles, M P and Matowe, L and Shirran, L and Wensing, M and Dijkstra, R and Donaldson, C}, journal = {Health technology assessment}, number = {6} }
@article{ title = {A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor.}, type = {article}, year = {2003}, identifiers = {[object Object]}, keywords = {Adult,Chromosomes, Human, Pair 22,Ependymoma,Ependymoma: diagnosis,Ependymoma: genetics,Female,Genes, Neurofibromatosis 2,Germ-Line Mutation,Humans,Loss of Heterozygosity,Male,Microsatellite Repeats,Pedigree,Spinal Neoplasms,Spinal Neoplasms: genetics}, pages = {598-602}, volume = {48}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/14566482}, month = {1}, id = {27bbabe4-815b-349a-bf02-494ff0fc34a0}, created = {2014-08-02T22:29:07.000Z}, accessed = {2014-08-02}, file_attached = {true}, profile_id = {be299c88-7105-3a8d-a1cd-3aa95c25e2c4}, group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2}, last_modified = {2014-12-29T21:45:19.000Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {Familial ependymal tumors are a very rare disease, the pathogenesis of which is unknown. Previous studies indicate an involvement of tumor suppressor genes localized within chromosomal region 22q, whereas details are still unclear. Here we report a non-neurofibromatosis type-2 (non-NF2) Japanese family in which two of the four members are affected with cervical spinal cord ependymoma, and one of the four is affected with schwannoma. Loss of heterozygosity (LOH) studies were carried out searching for common allelic loss at chromosomal region 22q11.2-qtel in two of the affected patients. Our findings support a prediction for existence of a tumor suppressor gene on chromosome 22 especially related to the tumorigenesis of familial ependymal tumors.}, bibtype = {article}, author = {Yokota, Takashi and Tachizawa, Takayuki and Fukino, Koichi and Teramoto, Akira and Kouno, Jun and Matsumoto, Koshi and Emi, Mitsuru}, journal = {Journal of human genetics}, number = {11} }
@Article{Antonov2003, author = {Igor Antonov and Irina Antonova and Eric R Kandel and Robert D Hawkins}, journal = {Neuron}, title = {Activity-dependent presynaptic facilitation and hebbian {LTP} are both required and interact during classical conditioning in {A}plysia.}, year = {2003}, number = {1}, pages = {135-47}, volume = {37}, abstract = {Using a simplified preparation of the Aplysia siphon-withdrawal reflex, we previously found that associative plasticity at synapses between sensory neurons and motor neurons contributes importantly to classical conditioning of the reflex. We have now tested the roles in that plasticity of two associative cellular mechanisms: activity-dependent enhancement of presynaptic facilitation and postsynaptically induced long-term potentiation. By perturbing molecular signaling pathways in individual neurons, we have provided the most direct evidence to date that each of these mechanisms contributes to behavioral learning. In addition, our results suggest that the two mechanisms are not independent but rather interact through retrograde signaling.}, keywords = {Amygdala, Animals, Evaluation Studies, Hippocampus, Human, Learning, Long-Term Potentiation, Memory, Models, Neurological, Neural Pathways, Neuronal Plasticity, Support, Non-U.S. Gov't, Synapses, 2-Amino-5-phosphonovalerate, Electric Stimulation, Isomerism, Rats, Receptors, N-Methyl-D-Aspartate, Neurotransmitter, Valine, Visual Perception, Action Potentials, Calcium Signaling, Central Nervous System, Chelating Agents, Conditioning (Psychology), Cyclic AMP-Dependent Protein Kinases, Enzyme Inhibitors, Excitatory Amino Acid Antagonists, Motor Neurons, Neurons, Afferent, Reaction Time, Reflex, Signal Transduction, U.S. Gov't, P.H.S., Synaptic Transmission, 12526779}, }
@Article{Fishbach2003, author = {Alon Fishbach and Yehezkel Yeshurun and Israel Nelken}, journal = {J Neurophysiol}, title = {Neural model for physiological responses to frequency and amplitude transitions uncovers topographical order in the auditory cortex.}, year = {2003}, number = {6}, pages = {3663-78}, volume = {90}, abstract = {We characterize primary auditory cortex (AI) units using a neural model for the detection of frequency and amplitude transitions. The model is a generalization of a model for the detection of amplitude transition. A set of neurons, tuned in the spectrotemporal domain, is created by means of neural delays and frequency filtering. The sensitivity of the model to frequency and amplitude transitions is achieved by applying a 2-dimensional rotatable receptive field to the set of spectrotemporally tuned neurons. We evaluated the model using data recorded in AI of anesthetized ferrets. We show that the model is able to fit the responses of AI units to variety of stimuli, including single tones, delayed 2-tone stimuli and various frequency-modulated tones, using only a small number of parameters. Furthermore, we show that the topographical order in maps of the model parameters is higher than in maps created from response indices extracted directly from the responses to any single stimulus. These results suggest a possible ordered organization of a simple rotatable spectrotemporal receptive field in the mammalian AI.}, doi = {10.1152/jn.00654.2003}, keywords = {Acoustic Stimulation, Algorithms, Artificial Intelligence, Auditory Cortex, Brain Mapping, Cluster Analysis, Computer Simulation, Human, Loudness Perception, Models, Neurological, Neurons, Pitch Perception, Reproducibility of Results, Support, U.S. Gov, ', t, Non-P.H.S., 14665682}, }
@article{pylyshyn_mental_2002, title = {Mental imagery: in search of a theory}, volume = {25}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12744144}, doi = {10/dsk54w}, abstract = {It is generally accepted that there is something special about reasoning by using mental images. The question of how it is special, however, has never been satisfactorily spelled out, despite more than thirty years of research in the post-behaviorist tradition. This article considers some of the general motivation for the assumption that entertaining mental images involves inspecting a picture-like object. It sets out a distinction between phenomena attributable to the nature of mind to what is called the cognitive architecture, and ones that are attributable to tacit knowledge used to simulate what would happen in a visual situation. With this distinction in mind, the paper then considers in detail the widely held assumption that in some important sense images are spatially displayed or are depictive, and that examining images uses the same mechanisms that are deployed in visual perception. I argue that the assumption of the spatial or depictive nature of images is only explanatory if taken literally, as a claim about how images are physically instantiated in the brain, and that the literal view fails for a number of empirical reasons--for example, because of the cognitive penetrability of the phenomena cited in its favor. Similarly, while it is arguably the case that imagery and vision involve some of the same mechanisms, this tells us very little about the nature of mental imagery and does not support claims about the pictorial nature of mental images. Finally, I consider whether recent neuroscience evidence clarifies the debate over the nature of mental images. I claim that when such questions as whether images are depictive or spatial are formulated more clearly, the evidence does not provide support for the picture-theory over a symbol-structure theory of mental imagery. Even if all the empirical claims were true, they do not warrant the conclusion that many people have drawn from them: that mental images are depictive or are displayed in some (possibly cortical) space. Such a conclusion is incompatible with what is known about how images function in thought. We are then left with the provisional counterintuitive conclusion that the available evidence does not support rejection of what I call the "null hypothesis"; namely, that reasoning with mental images involves the same form of representation and the same processes as that of reasoning in general, except that the content or subject matter of thoughts experienced as images includes information about how things would look.}, number = {2}, journal = {Behavioral and Brain Sciences}, author = {Pylyshyn, Z.W.}, year = {2002}, keywords = {*Psychological Theory, Awareness/physiology, Cerebral Cortex/physiology, Concept Formation/physiology, Human, Imagination/*physiology, Pattern Recognition, Visual/*physiology, Reproducibility of Results, Space Perception/*physiology, Support, U.S. Gov't, P.H.S., Thinking/*physiology, Visual Pathways/physiology}, pages = {157--182; discussion 182--237}, }
@article{ title = {Linkage disequilibrium and the mapping of complex human traits}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {*Linkage Disequilibrium,Chromosome Mapping,Genetics, Population,Genome, Human,Haplotypes,Human,Support, U.S. Gov't, P.H.S.}, pages = {19-24}, volume = {18}, id = {7d822191-046f-3d40-ba67-325d8361f589}, created = {2017-06-19T13:45:30.585Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:30.763Z}, tags = {03/07/22}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article</m:note>}, abstract = {The potential value of haplotypes defined by several single nucleotide polymorphisms has attracted recent interest. With sufficient linkage disequilibrium (LD), haplotypes could be used in association studies to map common alleles that might influence the susceptibility to common diseases, as well as for reconstructing the evolution of the genome. It has been proposed that a globally useful resource need only be based on high frequency variants, identified from a few modest samples. Rapid progress has been made in quantifying the pattern of human LD and haplotypes defined by such common variants within and among populations. However, the quality and utility of the proposed LD-based resource could be seriously compromised if important sampling and analytical factors are overlooked in its design. The LD map should be based on adequately justified criteria defined by sound population genetic principles.}, bibtype = {article}, author = {Weiss, K M and Clark, A G}, journal = {Trends Genet}, number = {1} }
@article{ title = {Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {*Pedigree,Algorithms,Alleles,Bayes Theorem,Bias (Epidemiology),Case-Control Studies,Chromosome Mapping/*methods/statistics & numerical,Computer Simulation,Cystic Fibrosis Transmembrane Conductance Regulato,Cystic Fibrosis/*genetics,Female,Genetic Heterogeneity,Genetic Markers/genetics,Haplotypes/genetics,Human,Linkage Disequilibrium/genetics,Male,Markov Chains,Models, Genetic,Monte Carlo Method,Mutation/genetics,Phylogeny,Probability,Recombination, Genetic/genetics,Sequence Deletion,Support, Non-U.S. Gov't}, pages = {686-707.}, volume = {70}, id = {b7168238-9085-3a82-81a6-a75268e0c428}, created = {2017-06-19T13:42:46.478Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:46.621Z}, tags = {02/04/26}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {We present a Bayesian, Markov-chain Monte Carlo method for fine-scale linkage-disequilibrium gene mapping using high-density marker maps. The method explicitly models the genealogy underlying a sample of case chromosomes in the vicinity of a putative disease locus, in contrast with the assumption of a star-shaped tree made by many existing multipoint methods. Within this modeling framework, we can allow for missing marker information and for uncertainty about the true underlying genealogy and the makeup of ancestral marker haplotypes. A crucial advantage of our method is the incorporation of the shattered coalescent model for genealogies, allowing for multiple founding mutations at the disease locus and for sporadic cases of disease. Output from the method includes approximate posterior distributions of the location of the disease locus and population-marker haplotype proportions. In addition, output from the algorithm is used to construct a cladogram to represent genetic heterogeneity at the disease locus, highlighting clusters of case chromosomes sharing the same mutation. We present detailed simulations to provide evidence of improvements over existing methodology. Furthermore, inferences about the location of the disease locus are shown to remain robust to modeling assumptions.}, bibtype = {article}, author = {Morris, A P and Whittaker, J C and Balding, D J}, journal = {Am J Hum Genet}, number = {3} }
@article{ title = {Harvesting the fruits of the human genome}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {*Genome,Gene Expression,Genetic Techniques,Human,Human Genome Project,Oligonucleotide Array Sequence Analysis,Polymorphism,Single Nucleotide}, pages = {227-8.}, volume = {27}, id = {bd123f8b-9bfd-34a8-9c41-b68042248e9d}, created = {2017-06-19T13:42:23.436Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:23.560Z}, tags = {01/11/30}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Comment<m:linebreak/>Editorial<m:linebreak/>Review<m:linebreak/>Review, Tutorial</m:note>}, bibtype = {article}, author = {Editorial, undefined}, journal = {Nat Genet}, number = {3} }
@article{ title = {Inbreeding in Gredos mountain range (Spain): contribution of multiple consanguinity and intervalley variation}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {*Consanguinity,Ethnic Groups/*genetics,Geography,Human,Probability,Socioeconomic Factors,Spain,Support, Non-U.S. Gov't,Time Factors}, pages = {249-70.}, volume = {73}, id = {cbd6acf1-d154-3cbf-8680-aafc30f04c2c}, created = {2017-06-19T13:42:23.243Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:23.412Z}, tags = {02/02/13}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {The present paper examines consanguineous marriages occurring between 1874 and 1975 in three valleys (Tormes, Alberche, and Tietar) in the Sierra de Gredos mountain range, Avila province, Spain. Information was obtained from parish registers of 42 localities, corresponding to a total of 41,696 weddings. Consanguineous marriages were defined as those up to the third degree of consanguinity (second cousins). From 1874 to 1975 the percentage of related mates was 4.45% and the inbreeding coefficient was 0.0011868 (for 1874 to 1917 corresponding figures up to the fourth degree were 16.44% and 0.00 19085, respectively). In order to ascertain the characteristics and evolution of mating patterns in Gredos, the contribution of each degree of kinship was analyzed as a whole and then for each valley separately. Regarding total consanguineous marriages in Gredos, there is a low frequency of uncle-niece matings (0.21%) and a first-second cousin mating ratio (C22/C33) of 0.23 (up to the third degree of consanguinity). Before 1918 multiple matings (i.e., those involving more than a single relationship) accounted for 19.16% of consanguineous marriages (up to the fourth degree). The observed frequencies of multiple consanguineous marriages was, on average, about twice that expected at random, and the proportion of such marriages to total inbreeding was 34.65%. The temporal change of the Gredos inbreeding pattern was characterized by a recent decrease; the highest inbreeding levels correspond to the period from 1915 to 1944. Finally, intervalley differences (maximum inbreeding coefficient in the Tormes, minimum in the Tietar) are interpreted considering the geography, population size, and population mobility for each valley}, bibtype = {article}, author = {Fuster, V and Jimenez, A M and Colantonio, S E}, journal = {Hum Biol}, number = {2} }
@article{ title = {Genomewide scans of complex human diseases: true linkage is hard to find.}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {Asthma,Asthma: genetics,Chromosome Mapping,Databases, Genetic,Diabetes Mellitus, Type 2,Diabetes Mellitus, Type 2: genetics,Disease,Genetic Linkage,Genetic Linkage: genetics,Genome, Human,Humans,Multifactorial Inheritance,Multifactorial Inheritance: genetics,Regression Analysis}, pages = {936-50}, volume = {69}, websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1274370&tool=pmcentrez&rendertype=abstract}, month = {11}, id = {5d3be54c-8b02-31dc-a3b4-3edb22218ebf}, created = {2017-06-19T13:41:50.038Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:41:50.188Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {Many "complex" human diseases, which involve multiple genetic and environmental determinants, have increased in incidence during the past 2 decades. During the same time period, considerable effort and expense have been expended in whole-genome screens aimed at detection of genetic loci contributing to the susceptibility to complex human diseases. However, the success of positional cloning attempts based on whole-genome screens has been limited, and many of the fundamental questions relating to the genetic epidemiology of complex human disease remain unanswered. Both to review the success of the positional cloning paradigm as applied to complex human disease and to investigate the characteristics of the whole-genome scans undertaken to date, we created a database of 101 studies of complex human disease, which were found by a systematic Medline search (current as of December 2000). We compared these studies, concerning 31 different human complex diseases, with regard to design, methods, and results. The "significance" categorizations proposed by Lander and Kruglyak were used as criteria for the "success" of a study. Most (66.3% [n=67]) of the studies did not show "significant" linkage when the criteria of Lander and Kruglyak (1995) were used, and the results of studies of the same disease were often inconsistent. Our analyses suggest that no single study design consistently produces more-significant results. Multivariate analysis suggests that the only factors independently associated with increased study success are (a) an increase in the number of individuals studied and (b) study of a sample drawn from only one ethnic group. Positional cloning based on whole-genome screens in complex human disease has proved more difficult than originally had been envisioned; detection of linkage and positional cloning of specific disease-susceptibility loci remains elusive.}, bibtype = {article}, author = {Altmüller, J and Palmer, L J and Fischer, G and Scherb, H and Wjst, M}, journal = {American journal of human genetics}, number = {5} }
@article{ title = {Differences in disease frequency between Europeans and Polynesians: directions for future research into genetic risk factors}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {Cardiovascular Diseases/epidemiology/ethnology/gen,Communicable Diseases/epidemiology/ethnology/genet,Comparative Study,Cross-Sectional Studies,Ethnic Groups/*genetics,Europe,Female,Genetic Predisposition to Disease/*ethnology,Human,Male,Mental Disorders/epidemiology/ethnology/genetics,Neoplasms/epidemiology/ethnology/genetics,Polynesia,Respiratory Tract Infections/epidemiology/ethnolog,Risk Factors,Support, Non-U.S. Gov't}, pages = {129-56.}, volume = {8}, id = {d2b1e45e-388c-3f80-aade-5bb60895ae60}, created = {2017-06-19T13:43:59.928Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:44:00.074Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article<m:linebreak/>Review<m:linebreak/>Review, Academic</m:note>}, abstract = {The purpose of this review is to identify complex genetic diseases that might be common in Polynesian ethnic groups because of a high frequency of susceptibility genes. Since a number of Polynesian ethnic groups are descended from recent founder populations, they may be especially suitable for studies designed to identify these genes. We have reviewed the epidemiological literature looking for diseases that i) have a higher frequency in at least two Polynesian groups than in Europeans living in the same geographic areas, ii) are not at high frequency in Polynesia entirely because of high levels of known environmental risk factors, and iii) are known to be inherited in other ethnic groups. Twenty-one diseases fulfilling these three criteria were identified. It may be possible to design studies to identify the genes that cause these diseases in Polynesian ethnic groups.}, bibtype = {article}, author = {Abbott, W and Scragg, R and Marbrook, J}, journal = {Pac Health Dialog}, number = {1} }
@Article{Wolff2001, author = {C Wolff and E Schr\"oger}, journal = {Brain Res Cogn Brain Res}, title = {Activation of the auditory pre-attentive change detection system by tone repetitions with fast stimulation rate.}, year = {2001}, number = {3}, pages = {323-7}, volume = {10}, abstract = {The human automatic pre-attentive change detection system indexed by the mismatch negativity (MMN) component of the auditory event-related brain potential is known to be highly adaptive. The present study showed that even infrequent repetitions of tones can elicit MMN, independently of attention, when tones of varying frequency are rapidly presented in an isochronous rhythm. This demonstrates that frequency variation can be extracted as an invariant feature of the acoustic environment revealing the capacity for adaptation of the auditory pre-attentive change detection system. It is argued that this capacity is related to the temporal-window of integration.}, keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, Broca, Encephalitis, Herpes Simplex, Infarction, Middle Cerebral Artery, X-Ray Computed, 11167055}, }
@article{ title = {After BRCA1 and BRCA2-what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {Age Factors,Age of Onset,Australia,BRCA1 Protein/*genetics,BRCA2 Protein,Breast Neoplasms/*genetics,Cohort Studies,Family Health,Female,Heterozygote,Human,Male,Models, Genetic,Molecular Sequence Data,Mutation,Neoplasm Proteins/*genetics,Pedigree,Probability,Risk Factors,Statistics,Support, Non-U.S. Gov't,Support, U.S. Gov't, P.H.S.,Transcription Factors/*genetics}, pages = {420-31.}, volume = {68}, id = {23f12ce0-3889-312a-be6e-926c320ad4f9}, created = {2017-06-19T13:45:18.919Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:19.048Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Mutations in BRCA1 and BRCA2 that cause a dominantly inherited high risk of female breast cancer seem to explain only a small proportion of the aggregation of the disease. To study the possible additional genetic components, we conducted single-locus and two-locus segregation analyses, with and without a polygenic background, using three-generation families ascertained through 858 women with breast cancer diagnosed at age <40 years, ascertained through population cancer registries in Melbourne and Sydney, Australia. Extensive testing for deleterious mutations in BRCA1 and BRCA2, to date, has identified 34 carriers. Our analysis suggested that, after other possible unmeasured familial factors are adjusted for and the known BRCA1 and BRCA2 mutation carriers are excluded, there appears to be a residual dominantly inherited risk of female breast cancer in addition to that derived from mutations in BRCA1 and BRCA2. This study also suggests that there is a substantial recessively inherited risk of early-onset breast cancer. According to the best-fitting model, after excluding known carriers of mutations in BRCA1 and BRCA2, about 1/250 (95% confidence interval [CI] 1/500 to 1/125) women have a recessive risk of 86% (95% CI 69%-100%) by age 50 years and of almost 100% by age 60 years. Possible reasons that our study has implicated a novel strong recessive effect include our inclusion of data on lineal aunts and grandmothers, study of families ascertained through women with early-onset breast cancer, allowance for multiple familial factors in the analysis, and removal of families for whom the cause (i.e., BRCA1 or BRCA2) is known. Our findings may have implications for attempts to identify new breast cancer-susceptibility genes.}, bibtype = {article}, author = {Cui, J and Antoniou, A C and Dite, G S and Southey, M C and Venter, D J and Easton, D F and Giles, G G and McCredie, M R and Hopper, J L}, journal = {Am J Hum Genet}, number = {2} }
@Article{Thoroughman2000, author = {KA Thoroughman and R Shadmehr}, journal = {Nature}, title = {Learning of action through adaptive combination of motor primitives.}, year = {2000}, number = {6805}, pages = {742-7}, volume = {407}, abstract = {Understanding how the brain constructs movements remains a fundamental challenge in neuroscience. The brain may control complex movements through flexible combination of motor primitives, where each primitive is an element of computation in the sensorimotor map that transforms desired limb trajectories into motor commands. Theoretical studies have shown that a system's ability to learn action depends on the shape of its primitives. Using a time-series analysis of error patterns, here we show that humans learn the dynamics of reaching movements through a flexible combination of primitives that have gaussian-like tuning functions encoding hand velocity. The wide tuning of the inferred primitives predicts limitations on the brain's ability to represent viscous dynamics. We find close agreement between the predicted limitations and the subjects' adaptation to new force fields. The mathematical properties of the derived primitives resemble the tuning curves of Purkinje cells in the cerebellum. The activity of these cells may encode primitives that underlie the learning of dynamics.}, doi = {10.1038/35037588}, keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, 11048700}, }
@article{lee_mapping_2000, title = {Mapping of functional organization in human visual cortex: electrical cortical stimulation}, volume = {54}, doi = {10/gpckkm}, abstract = {OBJECTIVES: To investigate the pattern of functional organization in the human visual cortex through electrical cortical stimulation. METHODS: Electrical cortical stimulation was applied to the occipital cortex and adjacent cortices using subdural grid electrodes in 23 epilepsy patients. Diverse visual responses were recorded. These responses were divided into different categories according to the specific response modalities, such as form, color, and motion. Form visual responses were further subdivided into simple, intermediate, and complex responses. The cortical localization of subdural electrodes was identified using MRI-CT coregistration. The cortical distribution of different visual responses was projected into three-dimensional surface renderings of the brain. The distribution and frequency of subdural electrodes showing different visual responses were quantified by calculating the percentage of the number of electrodes showing one specific type of visual response at the corresponding anatomic region to the total number of electrodes in all brain regions that produced the same response. RESULTS: Simple form responses were obtained mostly at the occipital pole and the inferior occipital gyrus (47.4\%) and the striate cortex (42.4\%). Intermediate form responses occurred mainly on the peristriate cortex (52.5\%) and the lateral occipital (28.0\%) and fusiform gyri (19.5\%). Complex forms were produced by stimulation of the basal temporo-occipital region (57.6\%) and the lateral temporal or lateral temporo-occipital junctional region (42.4\%). Color responses occurred on the basal occipital area, mostly at the fusiform (40.0\%) and lingual gyri (36.0\%). Moving sensations were evoked by stimulation of the basal temporo-occipital (28.4\%) and the mesial parieto-occipital or temporo-parieto-occipital junctional regions (23.9\%). CONCLUSIONS: Different modalities of vision, such as form, color, and moving sensation, appeared to be distributed and organized in different areas of the human visual cortex.}, number = {4}, journal = {Neurology}, author = {Lee, H.W. and Hong, S.B. and Seo, D.W. and Tae, W.S. and Hong, S.C.}, year = {2000}, keywords = {\#nosource, Adolescence, Adult, Brain Mapping, Electric Stimulation, Epilepsy/*pathology/*physiopathology, Female, Human, Magnetic Resonance Imaging, Male, Support, Non-U.S. Gov't, Visual Cortex/*pathology/*physiopathology}, pages = {849--54}, }
@article{ title = {Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry}, type = {article}, year = {1999}, identifiers = {[object Object]}, keywords = {Base Sequence,Canada,Canada/ethnology,Canada: ethnology,DNA-Binding Proteins,DNA-Binding Proteins/*genetics,DNA-Binding Proteins: genetics,Ethnic Groups,Ethnic Groups/*genetics,Ethnic Groups: genetics,Female,France,France/ethnology,France: ethnology,Human,Humans,Louisiana,Male,Microsatellite Repeats,Microsatellite Repeats/*genetics,Microsatellite Repeats: genetics,Muscular Dystrophies,Muscular Dystrophies/*genetics,Muscular Dystrophies: genetics,Non-U.S. Gov't,Pedigree,Poly(A)-Binding Protein II,Support}, pages = {477-481}, volume = {86}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/10508991}, month = {10}, day = {29}, id = {45d065a8-6799-3e6b-880b-3fa24b3356fa}, created = {2017-06-19T13:42:02.365Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:02.505Z}, tags = {04/09/07}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note> <m:bold>From Duplicate 1 ( </m:bold> <m:bold> </m:bold><m:bold><m:italic>Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry</m:italic></m:bold><m:bold> </m:bold> <m:bold> - Scacheri, P C; Garcia, C; Hebert, R; Hoffman, E P )<m:linebreak/> </m:bold> <m:linebreak/>Journal Article<m:linebreak/> <m:linebreak/> </m:note>}, abstract = {Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset autosomal dominant myopathy found world-wide, but with the highest incidence in French-Canadians. Short GCG expansions in the poly(A) binding protein 2 (PABP2) gene were identified recently as the molecular basis for OPMD in French-Canadians. All French-Canadian cases of OPMD have been traced to a single founder couple [Bouchard, 1997: Neuromuscul Disord 7(Suppl):S5-S11]. Cultural links between French-Canadians and Cajuns suggest that this same founder couple may have transmitted the OPMD mutation to Cajuns as well. To determine if OPMD patients from Louisiana share a founder effect with French-Canadian families, we collected blood samples and muscle biopsies from several Cajuns with OPMD for mutation and linkage studies. We found a unique 'GCA GCG GCG' insertion mutation in Cajuns. Consistent with these sequence data, we identified a disease haplotype in our Cajun families that is different from the ancestral haplotype defined in French-Canadians. These data prove that different founders introduced the PABP2 mutation to Cajuns and French-Canadians and lend support to emerging genealogical data suggesting that French-Canadians and Cajuns represent distinct immigrant groups from France.}, bibtype = {article}, author = {Scacheri, P C and Garcia, C and Hébert, R and Hoffman, E P and Hebert, R}, journal = {Am J Med Genet}, number = {5} }
@article{ title = {Visual-proprioceptive mapping in children with developmental coordination disorder}, type = {article}, year = {1999}, identifiers = {[object Object]}, keywords = {Case-Control Studies,Child,Female,Growth Disorders,Humans,Male,Motor Skills,Preschool,Proprioception,Vision,physiopathology,psychology}, pages = {247-254}, volume = {41}, id = {2a1d6312-9620-3630-b63f-f17c2d8e07ef}, created = {2016-01-12T14:17:48.000Z}, file_attached = {false}, profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd}, last_modified = {2017-03-16T06:19:45.131Z}, read = {false}, starred = {false}, authored = {true}, confirmed = {true}, hidden = {false}, abstract = {Developmental coordination disorder (DCD) occurs in a small but significant proportion of children who present with impaired body-eye coordination and show poor acquisition of motor skills. This study investigated the visual-proprioceptive mapping ability of children with DCD from a small selected group, with particular reference to the use of vision in matching tasks. The children with DCD in this study were significantly poorer than control children on all matching tasks. They seemed to have particular difficulty in cross-modal judgements that required the use of visual information to guide proprioceptive judgements of limb position. A distinction is drawn between tasks that can be achieved purely through sensory matching and those that require body-centred spatial judgements, suggesting that it is the latter that posits a particular difficulty for children with DCD}, bibtype = {article}, author = {Mon-Williams, M A and Wann, J P and Pascal, E}, journal = {Developmental Medicine & Child Neurology}, number = {4} }
@article{ title = {The conceptual structure of research utilization}, type = {article}, year = {1999}, identifiers = {[object Object]}, id = {e8334dc3-a5a9-376c-ad94-9ea7843d072d}, created = {2016-12-15T22:52:55.000Z}, file_attached = {false}, profile_id = {369acd69-1fe7-313d-821e-cb7bbe1ddab2}, last_modified = {2017-03-25T14:39:59.517Z}, read = {false}, starred = {false}, authored = {true}, confirmed = {false}, hidden = {false}, private_publication = {false}, bibtype = {article}, author = {Estabrooks, C A} }
@Article{Eimas1999, author = {PD Eimas}, journal = {Science}, title = {Do infants learn grammar with algebra or statistics?}, year = {1999}, number = {5413}, pages = {435-6; author reply 436-7}, volume = {284}, keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, 9872745}, }
@article{rodriguez_perceptions_1999, title = {Perception's shadow: long-distance synchronization of human brain activity}, volume = {397}, doi = {10/fw7v3w}, abstract = {Transient periods of synchronization of oscillating neuronal discharges in the frequency range 30-80 Hz (gamma oscillations) have been proposed to act as an integrative mechanism that may bring a widely distributed set of neurons together into a coherent ensemble that underlies a cognitive act. Results of several experiments in animals provide support for this idea. In humans, gamma oscillations have been described both on the scalp (measured by electroencephalography and magnetoencephalography) and in intracortical recordings, but no direct participation of synchrony in a cognitive task has been demonstrated so far. Here we record electrical brain activity from subjects who are viewing ambiguous visual stimuli (perceived either as faces or as meaningless shapes). We show for the first time, to our knowledge, that only face perception induces a long-distance pattern of synchronization, corresponding to the moment of perception itself and to the ensuing motor response. A period of strong desynchronization marks the transition between the moment of perception and the motor response. We suggest that this desynchronization reflects a process of active uncoupling of the underlying neural ensembles that is necessary to proceed from one cognitive state to another.}, number = {6718}, journal = {Nature}, author = {Rodriguez, E. and George, N. and Lachaux, J.P. and Martinerie, J. and Renault, B. and Varela, F.J.}, year = {1999}, keywords = {\#nosource, *Cortical Synchronization, Adult, Cognition/*physiology, Electroencephalography, Face, Female, Human, Male, Reaction Time, Support, Non-U.S. Gov't, Visual Perception/*physiology}, pages = {430--433}, }
@article{ title = {Which of our genes makes us human?}, type = {article}, year = {1998}, keywords = {*Chromosomes, Human,*Genome,*Genome, Human,*Human Characteristics,*Sequence Analysis, DNA,Animal,Chromosome Mapping,Gene Expression,Human,Mutation,Pan troglodytes/genetics,Pongidae/*genetics,Sialic Acids/chemistry/physiology,Species Specificity}, pages = {1432-1434}, volume = {281}, id = {85b008be-1b1d-3c94-bd62-2d641fa111cc}, created = {2017-06-19T13:42:20.922Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:21.018Z}, tags = {03/11/21}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>News</m:note>}, bibtype = {article}, author = {Gibbons, A}, journal = {Science}, number = {5382} }
@article{ title = {Isonymy and the genetic structure of Switzerland. II. Isolation by distance}, type = {article}, year = {1998}, identifiers = {[object Object]}, keywords = {*Genetics, Population,*Names,Human,Support, Non-U.S. Gov't,Switzerland}, pages = {533-40.}, volume = {25}, id = {72003c35-a39f-3f4f-9304-3b9ab1179b6e}, created = {2017-06-19T13:45:55.271Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:55.408Z}, tags = {02/02/13}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Isolation by distance in Switzerland was detected comparing the surname distributions between Cantons. The decay of isonymy with geographic distance between Cantons was consistent with Malecot's exponential decay of kinship. Lasker's distance was defined as the negative value of the logarithm of isonymy between localities, and it was found that it is linearly and significantly correlated with the log of geographic distance, both within and between languages. The peculiar geographic and linguistic structure of the Confederation, where mountain barriers exist at short distances separating different languages, might explain the rapid changes in surname similarity. It was predicted that the frequency of markers linked to the Y chromosome would show a similar association with distance in Switzerland.}, bibtype = {article}, author = {Rodriguez-Larralde, A and Scapoli, C and Beretta, M and Nesti, C and Mamolini, E and Barrai, I}, journal = {Ann Hum Biol}, number = {6} }
@Article{Hahn1998, author = {U Hahn and N Chater}, journal = {Cognition}, title = {Similarity and rules: {D}istinct? {E}xhaustive? {E}mpirically distinguishable?}, year = {1998}, number = {2-3}, pages = {197-230}, volume = {65}, abstract = {The distinction between rule-based and similarity-based processes in cognition is of fundamental importance for cognitive science, and has been the focus of a large body of empirical research. However, intuitive uses of the distinction are subject to theoretical difficulties and their relation to empirical evidence is not clear. We propose a 'core' distinction between rule- and similarity-based processes, in terms of the way representations of stored information are 'matched' with the representation of a novel item. This explication captures the intuitively clear-cut cases of processes of each type, and resolves apparent problems with the rule/similarity distinction. Moreover, it provides a clear target for assessing the psychological and AI literatures. We show that many lines of psychological evidence are less conclusive than sometimes assumed, but suggest that converging lines of evidence may be persuasive. We then argue that the AI literature suggests that approaches which combine rules and similarity are an important new focus for empirical work.}, keywords = {Cognition, Concept Formation, Discrimination Learning, Human, Mental Recall, Problem Solving, Problem-Based Learning, Support, Non-U.S. Gov't, Thinking, 9557383}, }
@article{ title = {The twinning rates and epidemiological characteristics of births in southeast Uttar Pradesh, India}, type = {article}, year = {1997}, identifiers = {[object Object]}, keywords = {Adult,Birth Rate,Female,Human,India/epidemiology,Maternal Age,Parity,Pregnancy,Pregnancy Complications/*epidemiology,Pregnancy, Multiple/*statistics & numerical data,Seasons,Twins, Dizygotic,Twins, Monozygotic,Twins/*statistics & numerical data}, pages = {47-56}, volume = {46}, id = {529933bb-e6ef-3768-86f0-68daccc174e2}, created = {2017-06-19T13:43:38.550Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:43:38.682Z}, tags = {03/11/06}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article<m:linebreak/>Twin Study</m:note>}, abstract = {Birth statistics over a period of 5 years were analyzed to study epidemiological characteristics of twinning in Southeast Uttar Pradesh, India. The data revealed higher incidence of breech twins (11.84% of all cotwins) as compared to breech single births (2.18%). But the perinatal mortality and caesarean section rates were similar in both twin and singleton pregnancies. The cumulative twinning rate over the studied period was 11.70 per 1000 live births. The MZ and DZ twinning rates were estimated respectively as 3.67 and 8.03 per mill. The mean maternal age of sampled mothers was 26.42 years with one standard deviation of 5.30 years. The twinning rate for mothers over 35 years of age was about four times higher than that in mothers younger than 20 years. Incidentally, the twinning rate was the highest at parity four and a non-linear curve could more appropriately be fitted to the series of data. Seasonal variations were observed for both twin and singleton births. The highest frequency of births was observed from August through October. But seasonal index for twinning rate showed a clear bimodal distribution with peaks in April (223) and September (167).}, bibtype = {article}, author = {Sharma, K}, journal = {Acta Genet Med Gemellol (Roma)}, number = {1} }
@Article{Kitzes1996, author = {LM Kitzes and GS Hollrigel}, journal = {Hear Res}, title = {Response properties of units in the posterior auditory field deprived of input from the ipsilateral primary auditory cortex.}, year = {1996}, note = {as cited in \citeNP{Heil1998}}, number = {1-2}, pages = {120-30}, volume = {100}, abstract = {The influence of the ipsilateral primary auditory field (AI) on the response properties of neurons in the posterior auditory field (Field P) was examined in three cats anesthetized with sodium pentobarbital. Rate/level functions were obtained, by extracellular recording, from single units in Field P before (n = 38) and after (n = 50) subpial aspiration of AI. The ablations were primarily confined to the medial ectosylvian gyrus, although in one case extended into the high-frequency portion of the anterior auditory field. Comparisons between the behavior of units isolated before and after AI ablation failed to demonstrate any changes in the response properties of neurons in Field P attributable to the ablation. Nonmonotonic response profiles, first spike latency, variability in latency, threshold and maximal discharge rates of the units to acoustic stimuli were not significantly altered by the AI ablation. These results indicate that the basic response properties of neurons in Field P do not depend on input from the ipsilateral AI. This suggests that these properties are most likely determined by thalamic input or by circuitry within Field P.}, keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, 8922986}, }
@article{ title = {The heritability of happiness}, type = {article}, year = {1996}, identifiers = {[object Object]}, keywords = {*Genes,*Happiness,Chromosome Mapping,Human}, pages = {125-6.}, volume = {14}, id = {a34de1c6-d224-3664-9b15-aa17ba004a09}, created = {2017-06-19T13:43:59.225Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:43:59.319Z}, tags = {02/02/28}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>News</m:note>}, bibtype = {article}, author = {Hamer, D H}, journal = {Nat Genet}, number = {2} }
@article{ title = {The genetical archaeology of the human genome}, type = {article}, year = {1996}, identifiers = {[object Object]}, keywords = {*Gene Pool,*Genome, Human,DNA, Mitochondrial/genetics,Evolution, Molecular,Female,Human,Male,Models, Genetic,Phylogeny,Support, Non-U.S. Gov't,Variation (Genetics)/*genetics}, pages = {135-140}, volume = {14}, id = {da42c725-f648-32fa-a720-c48d07c5c47c}, created = {2017-06-19T13:46:05.495Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:46:05.676Z}, tags = {03/09/17}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article<m:linebreak/>Review<m:linebreak/>Review, Tutorial</m:note>}, abstract = {Palaentology and archaeology are disciplines that traditionally deal with the reconstruction of human origins and history. Recently, however, molecular genetics has come to make increasing contributions to this area. In particular, several data sets indicate that variation of the human gene pool originated in Africa within the last 200,000 years. Furthermore, the study of DNA sequences allows the detection of expansions in population size. Here we briefly summarize and exemplify how DNA sequences can be used to reconstruct the history of populations.}, bibtype = {article}, author = {von Haeseler, A and Sajantila, A and Paabo, S}, journal = {Nat Genet}, number = {2} }
@article{ title = {Variability of the genetic contribution of Quebec population founders associated to some deleterious genes}, type = {article}, year = {1995}, identifiers = {[object Object]}, keywords = {*Variation (Genetics),Genes/*genetics,Genetic Diseases,Human,Inborn/*genetics,Non-U.S. Gov't,Quebec,Support}, pages = {970-8.}, volume = {56}, id = {aca70703-612e-37dc-ad8a-67357d5d675c}, created = {2017-06-19T13:45:32.514Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:32.692Z}, tags = {03/06/15}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Relatively high frequencies of some rare inherited disorders can be found in the Saguenay Region (Quebec). To understand this phenomenon, a research project on the 17th-century founder effect that led to the formation of French Canadians' gene pool is being carried out. The focus of this study is on founders who contributed to the Saguenay gene pool and who are related to contemporary probands suffering from any one of five hereditary diseases: cystic fibrosis, tyrosinemia, hemochromatosis, Charlevoix-Saguenay spastic ataxia, and sensorimotor polyneuropathia with or without agenesis of the corpus callosum. A control group has been added for comparison purposes. Altogether, 545 ascending genealogies have been reconstructed, using the Interuniversity Institute for Population Research's RETRO database, leading to > 2,500 founders. The genetic contribution of each founder to each group has been measured. Results show that (1) nearly 80% of the individuals' gene pool come from founders who settled in Nouvelle-France in the 17th century, whatever the group; (2) 15% of the founders explain 90% of the total genetic contribution of the founders, but this pattern varies from one group to another; (3) there is no subgroup of founders more related to any given group of individuals.}, bibtype = {article}, author = {Heyer, E and Tremblay, M}, journal = {Am J Hum Genet}, number = {4} }
@article{seki_efficacy_1995, title = {The efficacy of kinesthetic reading treatment for pure alexia}, volume = {33}, doi = {10/bd5t4s}, abstract = {This paper presents an effective treatment for pure alexia by a type of single-case design, which we termed a "material-control single-case design" [Sugishita et al., Neuropsychologia, Vol. 31, 559-569, 1993]. Two patients with pure alexia were treated using kinesthetic reading (reading by tracing or copying the outline of each letter with the patient's finger). The results clearly demonstrated that both patients significantly improved their reading and copying performances. Their recovery of reading performance arose from improvement in copying. The results of tachistoscopic reading tests suggested that the patient obtained the ability to read without kinesthetic movements.}, number = {5}, journal = {Neuropsychologia}, author = {Seki, K. and Yajima, M. and Sugishita, M.}, year = {1995}, keywords = {\#nosource, *Kinesthesis, Adult, Brain/*physiopathology, Case Report, Dyslexia, Acquired/diagnosis/physiopathology/*therapy, Human, Language Disorders/etiology/therapy, Language Therapy, Magnetic Resonance Imaging, Male, Support, Non-U.S. Gov't, Thrombosis/complications/diagnosis/*physiopathology}, pages = {595--609}, }
@Article{Bavelier1994, author = {D Bavelier}, journal = {Cognition}, title = {Repetition blindness between visually different items: {T}he case of pictures and words.}, year = {1994}, number = {3}, pages = {199-236}, volume = {51}, abstract = {Repetition blindness (RB) is the failure to see or recall the second of two visually similar or identical items in rapid serial visual presentation. It was initially demonstrated by Kanwisher (1987), who proposed that a second token of a given word or object type cannot be established when the two items occur close in time. Bavelier and Potter (1992) showed that RB also occurs between visually different items that are phonologically similar. They proposed that RB may occur not only when the targets are physically similar, but also when they have to be registered or encoded in short-term memory (STM) along dimensions on which they are similar. This hypothesis predicts that RB between visually different items should not be restricted to words, but should occur with any stimuli, as long as the task requires these stimuli to be encoded along dimensions on which they are similar. Moreover, it also implies that a task that changes the preferred code of targets will affect the size of RB. The first prediction was confirmed by establishing RB between phonologically similar pictures and words, whether semantically related (the picture of a cat and the word "cat") or not (the picture of a sun and the word "son"), when using a task that requires phonological encoding (Experiments 1 and 2). The second prediction was also supported: the magnitude of RB depended on whether the task required similar or different codes for pictures and words (Experiments 3 and 4). These experiments confirm that RB between visually different items is due to the similarity of the codes initially used in STM. The results suggest that RB can occur at any step during the instantiation of a token, arising not only from a failure to create a new token, but also from a failure to stabilize an opened token. In this view, tokens are to be seen as dynamical entities, built over time as a function of type activation and task requirements, and varying in stability as a function of the information that is entered into them.}, keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, 8194301}, }
@article{ title = {Isolation by distance on the Island of Korcula: correlation analysis of distance measures}, type = {article}, year = {1988}, identifiers = {[object Object]}, keywords = {*Anthropometry,*Dermatoglyphics,*Genetics, Population,*Rural Population,*Social Environment,*Social Isolation,Female,Human,Male,Support, U.S. Gov't, Non-P.H.S.,Yugoslavia}, pages = {97-103.}, volume = {77}, id = {17517e63-11e9-3896-8f0a-960853e28e9c}, created = {2017-06-19T13:42:46.587Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:46.723Z}, tags = {02/03/08}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Within the framework of holistic anthropological investigations of the rural populations on the Island of Korcula, various measures of biological distances between eight villages were estimated (Mahalanobis' D2 for anthropometric, physiological, and dermatoglyphic traits); socio-cultural similarities and distances were determined (kinship coefficient estimated from migrational data and Hemming similarity measure estimated from linguistic data). A matrix of Spearman's rank correlation coefficients among these measures demonstrated a pattern of interdependencies, which we analysed further by principal components analysis. The first component reflects the cumulative effect of different processes acting on the initial gene distribution over a long period of time; the second component represents initial population structure; and the third component reflects recent migration influences.}, bibtype = {article}, author = {Rudan, P and Simic, D and Bennett, L A}, journal = {Am J Phys Anthropol}, number = {1} }
@Article{Phillips1985, author = {DP Phillips and JR Mendelson and MS Cynader and RM Douglas}, journal = {Exp Brain Res}, title = {Responses of single neurones in cat auditory cortex to time-varying stimuli: {F}requency-modulated tones of narrow excursion.}, year = {1985}, number = {3}, pages = {443-54}, volume = {58}, abstract = {In the primary auditory cortex of cats anaesthetized with nitrous oxide, single neurones were examined with respect to their responses to tone bursts and linear modulations of the frequency of an on-going continuous tone. Using FM ramps of 2.0 kHz excursion and varying centre frequency, each of 39 neurones was examined for its preference for the direction of frequency change of a ramp whose centre frequency was varied in and around the neurone's response area. Direction preference was strictly associated with the slopes of the cell's spike count-versus-frequency function over the frequency range covered by the ramp. Preferences for upward- and downward-directed ramps were associated with the low- and high-frequency slopes of the spike count function, respectively. The strength of the cell's direction preference was associated with the relative steepness of the spike count function over the frequency range covered by the ramp. The timing of discharges elicited by the frequency modulations was found to be the sum of the cell's latent period for tone bursts plus the time after ramp onset that the stimulus frequency fell within the neurone's response area. The implications of these data for the processing of narrow and broad frequency-modulated ramps are discussed.}, keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, 4007088}, }
@article{rothi_alexia_1981, title = {Alexia and agraphia with spared spelling and letter recognition abilities}, volume = {12}, doi = {10/df6tn2}, number = {1}, journal = {Brain and Language}, author = {Rothi, L.J. and Heilman, K.M.}, year = {1981}, keywords = {\#nosource, Agraphia/*physiopathology, Brain/physiopathology, Case Report, Dyslexia, Acquired/*physiopathology, Human, Language Tests, Male, Middle Age, Reading, Support, U.S. Gov't, P.H.S., Writing}, pages = {1--13}, }
@Article{Banks1975, author = {MS Banks and Richard N Aslin and RD Letson}, journal = {Science}, title = {Sensitive period for the development of human binocular vision.}, year = {1975}, number = {4215}, pages = {675-7}, volume = {190}, abstract = {Twenty-four subjects with abnormal binocular experience, due to a condition of convergent strabismus that existed during different periods of their lives, were tested. Interocular transfer of the tilt-aftereffect was used to assess binocularity. Individuals between 1 and 3 years of age are most susceptible to abnormal binocular experience.}, keywords = {Adolescent, Adult, Age Factors, Child, Preschool, Human, Infant, Newborn, Strabismus, Support, U.S. Gov't, P.H.S., Visual Cortex, Visual Perception, 1188363}, }