@article{grubbsMoralDisapprovalPerceived2018, title = {Moral Disapproval and Perceived Addiction to Internet Pornography: A Longitudinal Examination.}, author = {Grubbs, Joshua B. and Wilt, Joshua A. and Exline, Julie J. and Pargament, Kenneth I. and Kraus, Shane W.}, year = {2018}, month = apr, journal = {Addiction}, volume = {113}, number = {3}, pages = {496--506}, issn = {1360-0443 0965-2140}, doi = {10.1111/add.14007}, abstract = {BACKGROUND AND AIMS: Internet pornography use is an increasingly common, yet controversial, behavior. Whereas mental health communities are divided about potentially problematic use patterns, many lay people identify as feeling dysregulated or compulsive in their use. Prior work has labeled this tendency perceived addiction to internet pornography (PA). This study's aims were to (1) assess the association between PA at baseline and other factors, including actual levels of average daily pornography use and personality factors and (2) assess the associations between baseline variables and PA 1 year later. DESIGN: Two large-scale community samples were assessed using online survey methods, with subsets of each sample being recruited for follow-up surveys 1 year later. SETTING: United States. PARTICIPANTS: Participants were adults who had used pornography within the past 6 months recruited in two samples. Sample 1 (n = 1507) involved undergraduate students from three US universities and sample 2 (n = 782) involved web-using adults. Subsets of each sample (sample 1, n = 146; sample 2, n = 211) were surveyed again 1 year later. MEASUREMENTS: At baseline, we assessed average daily pornography use, PA and relevant predictors (e.g. trait neuroticism, trait self-control, trait entitlement, religiousness, moral disapproval of pornography use). One year later, we assessed PA. FINDINGS: Cross-sectionally, PA was correlated strongly with moral disapproval of pornography use [sample 1, Pearson's correlation: r = 0.68 (0.65, 0.70); sample 2, r = 0.58 (0.53, 0.63)]. Baseline moral disapproval [sample 1, r = 0.46 (0.33, 0.56); sample 2, r = 0.61 (0.51, 0.69)] and perceived addiction demonstrated relationships with perceived addiction 1 year later. We found inconclusive evidence of a substantial or significant association between pornography use and perceived addiction over time [sample 1, r = 0.13 (-0.02, 0.28); sample 2, r = 0.11 (-0.04, 0.25)]. CONCLUSIONS: Perceived addiction to internet pornography appears to be related strongly to moral scruples around pornography use, both concurrently and over time, rather than with the amount of daily pornography use itself.}, copyright = {(c) 2017 Society for the Study of Addiction.}, langid = {english}, pmid = {28833800}, keywords = {*Attitude to Health,*Compulsive sexual behavior,*Morals,*personality,*pornography,*religion,*self-perception,*sexuality,*Social Norms,Adult,Attitude to Health,Behavior; Addictive,Behavior; Addictive/*psychology,Compulsive sexual behavior,Control (Psychology),CONTROL (Psychology),Cross Sectional Studies,Cross-Sectional Studies,Descriptive Statistics,Erotica,Erotica/*psychology,ETHICS,Female,Follow-Up Studies,Human,Humans,Internet,INTERNET pornography addiction,Internet Pornography Addiction -- Classification,Longitudinal Studies,Male,Morality,Morals,Multicenter Studies,No terms assigned,Pearson's Correlation Coefficient,personality,Personality,PERSONALITY,pornography,Pornography,PORNOGRAPHY,PORNOGRAPHY -- Moral \& ethical aspects,Pornography -- Utilization,Prospective Studies,religion,Religion,self-perception,Self-Perception,self‐perception,Sexual Addiction,sexuality,Sexuality,Social Norms,Students,Students; Undergraduate,Students/psychology/statistics \& numerical data,Surveys and Questionnaires,United States,UNITED States,Universities,Young Adult}, file = {/Volumes/GoogleDrive/My Drive/Manuscripts/Zotero/storage/EIR8JK5B/Grubbs et al. - Moral disapproval and perceived addiction to inter.pdf;/Volumes/GoogleDrive/My Drive/Manuscripts/Zotero/storage/MCJ7KH6W/Grubbs et al. - 2018 - Moral disapproval and perceived addiction to inter.pdf;/Volumes/GoogleDrive/My Drive/Manuscripts/Zotero/storage/6SFFEZ33/abstract.html;/Volumes/GoogleDrive/My Drive/Manuscripts/Zotero/storage/B2BPPKVL/abstract.html} }
@misc{baker_s.c._systematic_2017, title = {Systematic {Review} of {Interventions} to {Reduce} {Psychiatric} {Morbidity} in {Parents} and {Children} {After} {PICU} {Admissions}}, url = {http://journals.lww.com/pccmjournal}, abstract = {OBJECTIVE:: To describe and evaluate interventions aimed at reducing psychiatric morbidity in parents and children discharged from PICU. DATA SOURCES:: A systematic review of the literature was undertaken, searching EMBASE, PSYCHinfo, MEDLINE, and CINAHL. Experts in the field were contacted to identify unpublished studies. STUDY SELECTION:: Exclusion criteria: Studies with participants above age 18 or drawn from a neonatal ICU, studies not in English, and those not measuring psychopathology. DATA EXTRACTION:: Seven hundred fifty-three articles initially identified were hand searched which identified three studies, with a further three studies found by contacting experts in the field. Of these, three were randomized controlled trials and three feasibility studies. DATA SYNTHESIS:: The interventions primarily targeted parents (particularly mothers), with the aim of reducing psychopathology especially posttraumatic stress disorder. Findings from these few studies demonstrated that interventions can lead to a reduction in parent and child psychopathology. Key ingredients of these interventions included psychoeducation, parent support after discharge, offering intervention to those families at high risk of developing psychopathology as identified by screening at the point of discharge, follow-up of all families with the aim of case finding, and specific interventions to target posttraumatic stress disorder symptoms. CONCLUSIONS:: Intervention studies are few but do lead to reductions in parent and child psychopathology. There is sufficient information to suggest some of these interventions could be supported and further evaluated. Copyright ©2017The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies}, journal = {Pediatric Critical Care Medicine}, author = {{Baker S.C.} and {Gledhill J.A.}}, year = {2017}, keywords = {*morbidity, *psychiatric intensive care unit, Child, Cinahl, Embase, Medline, Neonatal intensive care unit, PsycINFO, adult, case finding, controlled study, family study, feasibility study, female, follow up, human, intervention study, mental disease, mother, newborn, posttraumatic stress disorder, psychoeducation, screening, systematic review, young adult} }
@misc{dencker_a._midwife-led_2017, title = {Midwife-led maternity care in {Ireland} - a retrospective cohort study}, url = {http://www.biomedcentral.com/bmcpregnancychildbirth/}, abstract = {Background: Midwife-led maternity care is shown to be safe for women with low-risk during pregnancy. In Ireland, two midwife-led units (MLUs) were introduced in 2004 when a randomised controlled trial (the MidU study) was performed to compare MLU care with consultant-led care (CLU). Following study completion the two MLUs have remained as a maternity care option in Ireland. The aim of this study was to evaluate maternal and neonatal outcomes and transfer rates during six years in the larger of the MLU sites. Methods: MLU data for the six years 2008-2013 were retrospectively analysed, following ethical approval. Rates of transfer, reasons for transfer, mode of birth, and maternal and fetal outcomes were assessed. Linear-by-Linear Association trend analysis was used for categorical data to evaluate trends over the years and one-way ANOVA was used when comparing continuous variables. Results: During the study period, 3,884 women were registered at the MLU. The antenatal transfer rate was 37.4\% and 2,410 women came to labour in the MLU. Throughout labour and birth, 567 women (14.6\%) transferred to the CLU, of which 23 were transferred after birth due to need for suturing or postpartum hemorrhage. The most common reasons for intrapartum transfer were meconium stained liquor/abnormal fetal heart rate (30.3\%), delayed labour progress in first or second stage (24.9\%) and woman's wish for epidural analgesia (15.1\%). Of the 1,903 babies born in the MLU, 1,878 (98.7\%) were spontaneous vaginal births and 25 (1.3\%) were instrumental (ventouse/forceps). Only 25 babies (1.3\%) were admitted to neonatal intensive care unit. All spontaneous vaginal births from the MLU registered population, occurring in the study period in both the MLU and CLU settings (n = 2,785), were compared. In the MLU more often 1-2 midwives (90.9\% vs 69.7\%) cared for the women during birth, more women had three vaginal examinations or fewer (93.6\% vs 79.9\%) and gave birth in an upright position (standing, squatting or kneeling) (52.0\% vs 9.4\%), fewer women had an amniotomy (5.9\% vs 25.9\%) or episiotomy (3.4\% vs 9.7\%) and more women had a physiological management of third stage of labour (50.9\% vs 4.6\%). Conclusions: Midwife-led care is a safe option that could be offered to a large proportion of healthy pregnant women. With strict transfer criteria there are very few complications during labour and birth. Maternity units without the option of MLU care should consider its introduction. Copyright © 2017 The Author(s).}, journal = {BMC Pregnancy and Childbirth}, author = {{Dencker A.} and {Smith V.} and {McCann C.} and {Begley C.}}, year = {2017}, keywords = {*Ireland, *cohort analysis, *high risk pregnancy, *labor stage 3, *maternal care, *midwife, Neonatal intensive care unit, amniotomy, analysis of variance, consultation, controlled clinical trial, controlled study, epidural analgesia, episiotomy, female, fetus, fetus heart rate, fetus outcome, forceps, human, human tissue, liquid, major clinical study, male, meconium, newborn, pelvic examination, postpartum hemorrhage, pregnant woman, randomized controlled trial, standing, statistical model, vaginal delivery} }
@misc{kim_e.s._teduglutide:_2017, title = {Teduglutide: {A} {Review} in {Short} {Bowel} {Syndrome}}, url = {http://rd.springer.com/journal/40265}, abstract = {Subcutaneous teduglutide (Revestive), a glucagon-like peptide-2 analogue that increases intestinal absorption, is approved in the EU for the treatment of short bowel syndrome (SBS) in patients aged {\textgreater}1 year who are stable following a period of postsurgical intestinal adaptation. In a phase III trial in adults with SBS intestinal failure (IF) dependent on parenteral support (PS), a significantly greater proportion of teduglutide 0.05 mg/kg/day than placebo recipients achieved a {\textgreater}20\% reduction in weekly PS volume from baseline to week 20 and maintained it to week 24. The proportion of patients who had a reduction in one or more days on PS was also significant with teduglutide compared with placebo. Improved intestinal absorption and reduced PS requirements were generally maintained in the longer term. Results from a phase III trial in paediatric patients with SBS-IF dependent on PS were consistent with those in adults. Adverse events were mostly of mild to moderate severity and generally consistent with the underlying condition or known mechanism of the drug (e.g. central line-related issues, gastrointestinal events). Teduglutide is therefore a useful treatment option in children (aged {\textgreater}1 year), adolescents and adults with SBS. Copyright © 2017, Springer International Publishing Switzerland. All Right Reserved.}, journal = {Drugs}, author = {{Kim E.S.} and {Keam S.J.}}, year = {2017}, keywords = {*short bowel syndrome, *short bowel syndrome/dt [Drug Therapy], *short bowel syndrome/th [Therapy], *teduglutide, *teduglutide/ae [Adverse Drug Reaction], *teduglutide/dt [Drug Therapy], *teduglutide/pd [Pharmacology], *teduglutide/pk [Pharmacokinetics], *teduglutide/sc [Subcutaneous Drug Administration], Child, Parenteral nutrition, abdominal distension/si [Side Effect], acute cholecystitis/si [Side Effect], adolescent, adult, adverse drug reaction, article, catheter infection/co [Complication], central venous catheter, central venous catheter/am [Adverse Device Effect], clinical study, clinical trial, controlled clinical trial, controlled study, decreased appetite/si [Side Effect], disease severity, drug efficacy, drug therapy, drug tolerability, gastrointestinal dysplasia/si [Side Effect], gastrointestinal polyposis/si [Side Effect], gastrointestinal symptom/si [Side Effect], gastrointestinal tract, gastrointestinal tumor/si [Side Effect], human, infant, influenza/si [Side Effect], injection site erythema/si [Side Effect], intestinal failure, intestine absorption, intestine polyp/si [Side Effect], intestine stenosis/si [Side Effect], multicenter study (topic), nonhuman, peripheral edema/si [Side Effect], pharmacodynamic parameters, phase 3 clinical trial, phase 3 clinical trial (topic), placebo, recipient, rectum polyp/si [Side Effect], rhinopharyngitis/si [Side Effect], sepsis/co [Complication], short bowel syndrome/dt [Drug Therapy], side effect, stomach adenoma/si [Side Effect], systematic review, upper abdominal pain/si [Side Effect]} }
@misc{barrington_k.j._nitric_2017, title = {Nitric oxide for respiratory failure in infants born at or near term}, url = {http://as.wiley.com/WileyCDA/Brand/id-6.html}, abstract = {Background: Nitric oxide (NO) is a major endogenous regulator of vascular tone. Inhaled nitric oxide (iNO) gas has been investigated as treatment for persistent pulmonary hypertension of the newborn. Objectives: To determine whether treatment of hypoxaemic term and near-term newborn infants with iNO improves oxygenation and reduces rate of death and use of extracorporeal membrane oxygenation (ECMO), or affects long-term neurodevelopmental outcomes. Search methods: We used the standard search strategy of the Cochrane Neonatal Review Group to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE via PubMed (1966 to January 2016), Embase (1980 to January 2016) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 to January 2016). We searched clinical trials databases, conference proceedings and reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials. We contacted the principal investigators of studies published as abstracts to ascertain the necessary information. Selection criteria: Randomised studies of iNO in term and near-term infants with hypoxic respiratory failure, with clinically relevant outcomes, including death, use of ECMO and oxygenation. Data collection and analysis: We analysed trial reports to assess methodological quality using the criteria of the Cochrane Neonatal Review Group. We tabulated mortality, oxygenation, short-term clinical outcomes (particularly use of ECMO) and long-term developmental outcomes. Statistics: For categorical outcomes, we calculated typical estimates for risk ratios and risk differences. For continuous variables, we calculated typical estimates for weighted mean differences. We used 95\% confidence intervals and assumed a fixed-effect model for meta-analysis. Main results: We found 17 eligible randomised controlled studies that included term and near-term infants with hypoxia. Ten trials compared iNO versus control (placebo or standard care without iNO) in infants with moderate or severe severity of illness scores (Ninos 1996; Roberts 1996; Wessel 1996; Davidson 1997; Ninos 1997; Mercier 1998; Christou 2000; Clark 2000; INNOVO 2007; Liu 2008). Mercier 1998 compared iNO versus control but allowed back-up treatment with iNO for infants who continued to satisfy the same criteria for severity of illness after two hours. This trial enrolled both preterm and term infants but reported most results separately for the two groups. Ninos 1997 studied only infants with congenital diaphragmatic hernia. One trial compared iNO versus high-frequency ventilation (Kinsella 1997). Six trials enrolled infants with moderate severity of illness scores (oxygenation index (OI) or alveolar-arterial oxygen difference (A-aDO2)) and randomised them to immediate iNO treatment or iNO treatment only after deterioration to more severe criteria (Barefield 1996; Day 1996; Sadiq 1998; Cornfield 1999; Konduri 2004; Gonzalez 2010). Inhaled nitric oxide appears to have improved outcomes in hypoxaemic term and near-term infants by reducing the incidence of the combined endpoint of death or use of ECMO (high-quality evidence). This reduction was due to a reduction in use of ECMO (with number needed to treat for an additional beneficial outcome (NNTB) of 5.3); mortality was not affected. Oxygenation was improved in approximately 50\% of infants receiving iNO. The OI was decreased by a (weighted) mean of 15.1 within 30 to 60 minutes after the start of therapy, and partial pressure of arterial oxygen (PaO2) was increased by a mean of 53 mmHg. Whether infants had clear echocardiographic evidence of persistent pulmonary hypertension of the newborn (PPHN) did not appear to affect response to iNO. Outcomes of infants with diaphragmatic hernia were not improved; outcomes were slightly, but not significantly, worse with iNO (moderate-quality evidence). Infants who received iNO at less severe criteria did not have better clinical outcomes than those who were enrolled but received treatment only if their condition deteriorated. Fewer of the babies who received iNO early satisfied late treatment criteria, showing that earlier iNO reduced progression of the disease but did not further decrease mortality nor the need for ECMO (moderate-quality evidence). Incidence of disability, incidence of deafness and infant development scores were all similar between tested survivors who received iNO and those who did not. Authors' conclusions: Inhaled nitric oxide is effective at an initial concentration of 20 ppm for term and near-term infants with hypoxic respiratory failure who do not have a diaphragmatic hernia. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley \& Sons, Ltd.}, journal = {Cochrane Database of Systematic Reviews}, author = {{Barrington K.J.} and {Finer N.} and {Pennaforte T.} and {Altit G.}}, year = {2017}, keywords = {*childbirth, *nitric oxide, *respiratory failure, Cinahl, Cochrane Library, Embase, Medline, arterial oxygen tension, attributable risk, cerebral palsy, child development, clinical outcome, confidence interval, congenital diaphragm hernia, controlled clinical trial, controlled study, death, deterioration, disability, disease severity, exposure, extracorporeal oxygenation, hearing impairment, high frequency ventilation, human, hypoxia, infant, infant mortality, information processing, lung vascular resistance, meta analysis, mortality, newborn, oxygen, oxygenation, partial pressure, persistent pulmonary hypertension, placebo, priority journal, randomized controlled trial, review, sensitivity analysis, statistics, survivor, systematic review, tissue oxygenation} }
@misc{hibbert_t._exploring_2017, title = {Exploring the role of health beliefs and pregnancy related experience of women with recent gestational diabetes, in maintaining healthy lifestyles after childbirth: {Focus} group experience from a large general practice surgery in {Newham}, {East} {London}}, abstract = {Introduction: Gestational diabetes (GDM), a well recognised risk factor for subsequent Type 2 diabetes, is increasing in places with large multi-ethnic populations like East London. Aims: 1. Recruit women who have been through recent GDM pregnancy from one general practice GDM register to a focus group. 2. Understand their challenges and perceptions postpartum. Method: Twenty-seven postal invitations were sent (one in five women selected randomly from the GDM register) followed up by a telephone call to every third woman until there were ten confirmed attendees. A text message reminder was sent the day before the focus group which was facilitated by an independent researcher at a local leisure centre. Results: Two initial responses following postal invitations with a further eight after the telephone call, with 100\% attendance on the day. Focus group feedback: * There was good knowledge of diabetes risk following GDM. * An acknowledgement that it was difficult to sustain intensive lifestyle changes after delivery, but gradual improvement was possible. * Many viewed hospital consultants as "scare mongering" and felt specialist nurses conveyed messages better. * All agreed they had received intensive antenatal care but postnatal follow-up was patchy; better support immediately postpartum, preferably locally e.g. GP surgery would help them maintain antenatal changes. Conclusions: Women with previous GDM prefer sustained lifestyle support continued immediately postpartum, through more bespoke programmes, delivered locally, addressing the needs of new mothers. Participation is improved by personal invitation and telephone reminders. This is useful when delivering postpartum diabetes prevention programmes.}, journal = {Diabetic Medicine}, author = {{Hibbert T.} and {Collard A.} and {Vijayaraghavan S.}}, year = {2017}, keywords = {*England, *childbirth, *general practice, *health belief, *healthy lifestyle, *pregnancy diabetes mellitus, clinical article, consultation, doctor patient relation, female, follow up, human, lifestyle modification, mother, nurse, perception, prenatal care, prevention, scientist, surgery, telephone} }
@misc{totonchi_z._effect_2017, title = {Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: {A} randomized trial}, url = {http://cardiovascmed.com/72535.pdf}, abstract = {Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.}, journal = {Research in Cardiovascular Medicine}, author = {{Totonchi Z.} and {Rezvani H.} and {Ghorbanloo M.} and {Yazdanian F.} and {Mahdavi M.} and {Babaali N.} and {Salajegheh S.} and {Chitsazan M.}}, year = {2017}, keywords = {*chemical stress, *dexmedetomidine, *dexmedetomidine/ct [Clinical Trial], *diastolic blood pressure, *heart surgery, *hemodynamics, *infusion, *open heart surgery, *stress, Anesthesia, C reactive protein, C reactive protein/ec [Endogenous Compound], Child, adjuvant, artery catheter, article, cardiopulmonary bypass, central venous catheter, central venous pressure, clinical article, clinical trial, continuous infusion, control group, controlled clinical trial, controlled study, diastolic blood pressure, drug therapy, endogenous compound, female, fentanyl, heart rate, human, hypertension, hypotension, incidence, infant, inflammation, intensive care unit, interleukin 6, interleukin 6/ec [Endogenous Compound], lactate dehydrogenase/ec [Endogenous Compound], lactic acid, loading drug dose, lymphotoxin beta, maintenance drug dose, male, midazolam, normal human, preschool child, prospective study, randomized controlled trial, sampling, single blind procedure, skin incision, sodium chloride, sternotomy, systolic blood pressure, tumor necrosis factor/ec [Endogenous Compound]} }
@misc{paterson_m.a._increasing_2017, title = {Increasing the protein quantity in a meal results in dose-dependent effects on postprandial glucose levels in individuals with {Type} 1 diabetes mellitus}, url = {http://www3.interscience.wiley.com/journal/119818374/grouphome/home.html}, abstract = {Aim: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods: Participants with Type 1 diabetes [aged 10-40 years, HbA1c {\textless} 64 mmol/mol (8\%), BMI {\textless} 91st percentile] received a 30-g carbohydrate (negligible fat) test drink daily over 5 days in randomized order. Protein (whey isolate 0 g/kg carbohydrate, 0 g/kg lipid) was added in amounts of 0 (control), 12.5, 25, 50 and 75 g. A standardized dose of insulin was given for the carbohydrate. Postprandial glycaemia was assessed by 5 h of continuous glucose monitoring. Results: Data were collected from 27 participants (15 male). A dose-response relationship was found with increasing amount of protein. A significant negative relationship between protein dose and mean excursion was seen at the 30- and 60-min time points (P = 0.007 and P = 0.002, respectively). No significant relationship was seen at the 90- and 120-min time points. Thereafter, the dose-response relationship inverted, such that there was a significant positive relationship for each of the 150-300-min time points (P {\textless} 0.004). Mean glycaemic excursions were significantly greater for all protein-added test drinks from 150 to 300 min (P {\textless} 0.005) with the 75-g protein load, resulting in a mean excursion that was 5 mmol/l higher when compared with the control test drink (P {\textless} 0.001). Conclusions: Increasing protein quantity in a low-fat meal containing consistent amounts of carbohydrate decreases glucose excursions in the early (0-60-min) postprandial period and then increases in the later postprandial period in a dose-dependent manner. Copyright © 2017 Diabetes UK.}, journal = {Diabetic Medicine}, author = {{Paterson M.A.} and {Smart C.E.M.} and {Lopez P.E.} and {Howley P.} and {Mcelduff P.} and {Attia J.} and {Morbey C.} and {King B.R.}}, year = {2017}, keywords = {*blood glucose monitoring, *insulin dependent diabetes mellitus, Child, body mass, clinical article, clinical trial, controlled clinical trial, controlled study, dose response, female, glucose, hemoglobin A1c, human, insulin, insulin treatment, lipid, lipid diet, male, postprandial state, randomized controlled trial, school child, whey} }
@misc{soares_s.m.f._effects_2017, title = {The effects of tracheal tube cuffs filled with air, saline or alkalinised lidocaine on haemodynamic changes and laryngotracheal morbidity in children: a randomised, controlled trial}, url = {http://www.interscience.wiley.com/jpages/0003-2409}, abstract = {We studied the effects of tracheal tube cuffs filled with air, saline or alkalinised lidocaine on haemodynamic changes during tracheal extubation and postoperative laryngotracheal morbidity in children. We randomly allocated 164 children aged 3-13 years undergoing general anaesthesia to one of four groups; tracheal tube cuffs filled with air (n = 41); saline (n = 41); alkalinised lidocaine 0.5\% (n = 41); or alkalinised lidocaine 1\% (n = 41). Intracuff pressure was monitored and maintained below 20 cmH2O. The mean (SD) increases in systolic blood pressure after tracheal extubation compared with before extubation were 10.9 (10.8) mmHg, 7.3 (17.7) mmHg, 4.1 (10.5) mmHg and 1.9 (9.5) mmHg in the air, saline, 0.5\% and 1\% alkalinised lidocaine groups, respectively (p = 0.021). The mean (SD) increases in diastolic blood pressure after tracheal extubation compared with before extubation were 3.9 (9.7) mmHg, 7.9 (14.6) mmHg, 0.7 (10.4) mmHg and 3.6 (6.9) mmHg in the air, saline, 0.5\% and 1\% alkalinised lidocaine groups, respectively (p = 0.019). The mean (SD) increases in heart rate after tracheal extubation compared with before extubation were 14.2 (7.6) beats.min-1, 15.5 (13.1) beats.min-1, 5.2 (9.6) beats.min-1 and 4.1 (6.6) beats.min-1 in the air, saline, 0.5\% and 1\% alkalinised lidocaine groups, respectively (p {\textless} 0.001). The incidence of sore throat 8 h after tracheal extubation was 22.0\% in the air-filled group, 9.8\% in the saline group, 4.9\% in the 0.5\% alkalinised lidocaine group and 2.4\% in the 1\% alkalinised lidocaine group, p = 0.015. We conclude that filling the tracheal tube cuff with alkalinised lidocaine-filled reduces the haemodynamic response to tracheal extubation and postoperative laryngotracheal morbidity in children. Copyright © 2016 The Association of Anaesthetists of Great Britain and Ireland}, journal = {Anaesthesia}, author = {{Soares S.M.F.} and {Arantes V.M.} and {Modolo M.P.} and {dos Santos V.J.B.} and {Vane L.A.} and {Navarro e Lima L.H.} and {Braz L.G.} and {do Nascimento P.} and {Modolo N.S.P.}}, year = {2017}, keywords = {*air, *childhood mortality, *diastolic blood pressure, *endotracheal tube, *endotracheal tube cuff, *lidocaine, *lung hemodynamics, *morbidity, *pediatrics, *pneumatic cuff, *respiration control, *sodium chloride, *sore throat, Child, adolescent, alfentanil, anesthesia induction, article, atropine, controlled clinical trial, controlled study, diastolic blood pressure, dipyrone, extubation, female, fentanyl, general anesthesia, heart rate, human, major clinical study, male, neostigmine, ondansetron, postoperative analgesia, preschool child, pressure measurement, propofol, randomized controlled trial, rocuronium, sevoflurane, sore throat/co [Complication], surgery, systolic blood pressure, tramadol} }
@misc{carlos_r.v._effect_2017, title = {The effect of prior tetanic stimulation on train-of-four monitoring in paediatric patients}, url = {http://journals.lww.com/ejanaesthesiology/pages/default.aspx}, abstract = {Background In clinical research, neuromuscular monitoring must present a stable response for a period of 2 to 5 min before administration of a neuromuscular blocking agent. The time required to reach this stable response may be shortened by applying a 5-s tetanic stimulus. OBJECTIVES The aim of this study was to test whether tetanic stimulation interferes with onset and recovery times after a single dose of rocuronium 0.6 mg kg+/-1 followed by spontaneous recovery. DESIGN A randomised, open-label, controlled trial. SETTING A single-centre trial, study period from January 2014 to July 2015. PATIENTS Fifty children aged 2 to 11 years scheduled for elective paediatric surgery. INTERVENTION Patients were randomly allocated to receive either tetanic stimulation (group T) or not (group C) before calibration of the neuromuscular monitor. MAIN OUTCOME MEASURES Onset and recovery times. Initial and final T1 height, time to obtain initial T1 height stability and monitor settings were also analysed. RESULTS There was no significant difference in mean onset time [(C: 57.5 (+/- 16.9) vs. T: 58.3 (+/- 31.2) s; P = 0.917]. Mean times to normalised train-of-four (TOF) ratios of 0.7, 0.8 and 0.9 were significantly shorter in the tetanic stimulation group [C: 40.1 (+/-7.9) vs. T: 34.8 (+/-10) min; P = 0.047, C: 43.8 (+/-9.4) vs. T: 37.4 (+/-11) min; P = 0.045 and C: 49.9 (+/-12.2) vs. T: 41.7 (+/-13.1) min; P = 0.026, respectively]. The mean time required for T1 height stabilisation was similar in the two groups [C: 195.0 (+/- 203.0) vs. T: 116.0 (+/- 81.6) s; P = 0.093], but the initial and final T1 height values were significantly lower in the tetanic stimulation group (C: 98.0 vs. T: 82.7\%; P {\textless} 0.001 and C: 95.3 vs. T: 69.3\%; P {\textless} 0.001, respectively). CONCLUSION Tetanic stimulation shortened the mean times to normalised TOF ratios of 0.7, 0.8 and 0.9, but there was no difference in the mean onset time or the mean time required for T1 height stabilisation after a single dose of rocuronium 0.6 mg kg+/-1 followed by spontaneous recovery in children aged 2 to 11 years. Copyright © 2017 European Society of Anaesthesiology. All rights reserved.}, journal = {European Journal of Anaesthesiology}, author = {{Carlos R.V.} and {De Boer H.D.} and {Torres M.L.A.} and {Carmona M.J.C.}}, year = {2017}, keywords = {*monitoring, *muscle excitation, *neuromuscular monitoring, *stimulus response, *tetanic stimulation, *train of four monitoring, Child, anesthetic recovery, article, calibration, clinical article, controlled clinical trial, controlled study, elective surgery, electric peripheral nerve stimulator, female, gas analysis equipment, height, human, male, open study, parameters, patient monitoring, pediatric surgery, randomized controlled trial, remission, rocuronium, single drug dose, thermal regulating system} }
@misc{van_boetzelaer_e._universal_2017, title = {Universal versus conditional three-day follow up visit for children with uncomplicated fever at the community level: {Design} of a cluster-randomized, community-based, non-inferiority trial in {Tanganyika}, {Democratic} {Republic} of {Congo}}, url = {http://www.biomedcentral.com/bmcpediatr/}, abstract = {Background: The current recommendation within integrated Community Case Management guidelines that all children presenting with uncomplicated fever and no danger signs be followed up after three days may not be necessary. Such fevers often resolve rapidly (usually within 48-96 h), and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aim to determine the non-inferiority of a conditional versus a universal follow-up visit for these children. Methods: We are conducting a cluster-randomized, community-based, non-inferiority trial enrolling {\textasciitilde}4300 children (ages 2-59 months) presenting to community health workers (CHWs) with uncomplicated fever in Tanganyika Province, Democratic Republic of the Congo. Clusters (n = 28) of CHWs are randomized to advise caretakers of such children to either 1) return for a follow-up visit on Day 3 following the initial consultation (Day 1), regardless of illness resolution (as per current guidelines) or 2) return for a follow-up visit on Day 3 only if the child's signs have not resolved. Enrolled children are followed up at Day 7 for a repeat assessment and recording of the primary outcome of the study, "failure", which is defined as having fever, diarrhea, pneumonia or decline of health status (e.g. hospitalization, presenting danger signs, or death). Discussion: The results of this trial will be interpreted in conjunction with a similarly designed trial currently ongoing in Ethiopia. If a follow-up visit conditional on continued illness is shown to be non-inferior to current guidelines stipulating universal follow-up, appropriate updating of such guidelines could reduce time and human resource pressures on both providers and caregivers throughout communities of sub-Saharan Africa and South Asia. Trial registration: This trial was registered at ClinicalTrials.gov (NCT02595827) on November 2nd, 2015 Copyright © 2017 The Author(s).}, journal = {BMC Pediatrics}, author = {{van Boetzelaer E.} and {Ho L.S.} and {Gutman J.R.} and {Steinhardt L.C.} and {Wittcoff A.} and {Barbera Y.} and {Ngoy P.} and {Harvey S.A.} and {Mullany L.C.}}, year = {2017}, keywords = {*Democratic Republic Congo, *Tanzania, *case management, *conditional three day follow up visit, *fever, *follow up, *health auxiliary, *pediatrics, *registration, *uncomplicated fever, *universal follow up visit, Child, Democratic Republic Congo, Ethiopia, South Asia, arm circumference, article, caregiver, clinical assessment, clinical protocol, clinical trial, consultation, controlled clinical trial, controlled study, death, diarrhea, feedback system, female, health auxiliary, health status, hospitalization, human, infant, information processing, major clinical study, male, midupper upper arm circumference, mortality, outcome assessment, patient monitoring, pneumonia, practice guideline, preschool child, quality control, randomization, randomized controlled trial, sample size, study design} }
@misc{al-biltagi_m.a.m._beneficial_2017, title = {Beneficial {Effects} of {Omega}-3 {Supplement} to the {Enteral} {Feeding} in {Children} with {Mild} to {Moderate} {Sepsis}}, abstract = {Objective: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Methods: The study was a prospective randomized, double-blind, placebo-controlled study from January 2012 to June 2014, which included 2 groups of children with mild to moderate sepsis tolerating enteral feeding. Group A included 60 children supplemented with omega-3 fatty acids, whereas group B included 60 children who received enteral feeding without omega-3 supplementation. Both groups had complete blood pictures, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum albumin, and IL-6 before and after 7 days from supplementation. Results: There was a significant improvement in hemoglobin percentage (P {\textless}.0001), total white blood cell (WBC) count (P {\textless}.0001), and platelet count (P {\textless}.0001) and significant decrease in CRP (P {\textless}.0001), ESR (P {\textless}.0001), IL-6 (P {\textless}.0001), and albumin level (P {\textless}.001) in the supplemented group than the nonsupplemented group. The supplemented group also had a significantly shorter duration of stay in pediatric intensive care unit (PICU; P {\textless}.01) and decreased death rate than the nonsupplemented group. Conclusion: Children with mild to moderate sepsis showed significant improvement in inflammatory markers and had shorter PICU admission when enteral feeding was supplemented with omega-3 essential fatty acids. Copyright © The Author(s) 2015.}, journal = {Journal of Intensive Care Medicine}, author = {{Al-Biltagi M.A.M.} and {Abo-Elezz A.A.E.} and {Abd-Elhafez M.A.} and {Mabrouk M.M.} and {Suliman G.A.}}, year = {2017}, keywords = {*diet supplementation, *enteric feeding, *erythrocyte sedimentation rate, *interleukin 6, *omega 3 fatty acid/ct [Clinical Trial], *omega 3 fatty acid/dt [Drug Therapy], *sepsis, *sepsis/dt [Drug Therapy], C reactive protein, C reactive protein/ec [Endogenous Compound], Child, acute phase protein, albumin, albumin/ec [Endogenous Compound], article, clinical trial, controlled clinical trial, controlled study, disease severity, docosahexaenoic acid, double blind procedure, drug efficacy, endogenous compound, erythrocyte sedimentation rate, essential fatty acid, female, gene expression, hemoglobin, hemoglobin/ec [Endogenous Compound], human, icosapentaenoic acid, interleukin 6/ec [Endogenous Compound], length of stay, leukocyte count, major clinical study, male, mortality rate, nutritional assessment, omega 3 fatty acid, pediatric intensive care unit, placebo, preschool child, priority journal, prospective study, randomized controlled trial, sepsis/dt [Drug Therapy], serum albumin, thrombocyte count, visually impaired person} }
@article{ title = {Assessing the psychedelic "after-glow" in ayahuasca users: Post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities}, type = {article}, year = {2017}, identifiers = {[object Object]}, keywords = {Ayahuasca,Human,Magnetic resonance Imaging,Mindfulness,Psychedelic After-effects}, pages = {698-711}, volume = {20}, websites = {https://academic.oup.com/ijnp/article-lookup/doi/10.1093/ijnp/pyx036}, id = {3f5e337e-0d03-39b1-830b-5aade057fc25}, created = {2017-11-10T18:19:09.331Z}, file_attached = {false}, profile_id = {38c6dbcb-2394-3f18-9217-58d777c08c69}, group_id = {d9389c6c-8ab5-3b8b-86ed-33db09ca0198}, last_modified = {2019-10-23T13:46:49.607Z}, tags = {OA,WP}, read = {true}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Sampedro}, private_publication = {false}, abstract = {Background: Ayahuasca is a plant tea containing the psychedelic 5-HT2A agonist N,N-dimethyltryptamine and harmala monoamine-oxidase inhibitors. Acute administration leads to neurophysiological modifications in brain regions of the default mode network, purportedly through a glutamatergic mechanism. Post-acutely, ayahuasca potentiates mindfulness capacities in volunteers and induces rapid and sustained antidepressant effects in treatment-resistant patients. However, the mechanisms underlying these fast and maintained effects are poorly understood. Here, we investigated in an open-label uncontrolled study in 16 healthy volunteers ayahuasca-induced post-acute neurometabolic and connectivity modifications and their association with mindfulness measures. Methods: Using 1H-magnetic resonance spectroscopy and functional connectivity, we compared baseline and post-acute neurometabolites and seed-to-voxel connectivity in the posterior and anterior cingulate cortex after a single ayahuasca dose. Results: Magnetic resonance spectroscopy showed post-acute reductions in glutamate+glutamine, creatine, and N-acetylaspartate+N-acetylaspartylglutamate in the posterior cingulate cortex. Connectivity was increased between the posterior cingulate cortex and the anterior cingulate cortex, and between the anterior cingulate cortex and limbic structures in the right medial temporal lobe. Glutamate+glutamine reductions correlated with increases in the “nonjudging” subscale of the Five Facets Mindfulness Questionnaire. Increased anterior cingulate cortex-medial temporal lobe connectivity correlated with increased scores on the self-compassion questionnaire. Post-acute neural changes predicted sustained elevations in nonjudging 2 months later. Conclusions: These results support the involvement of glutamate neurotransmission in the effects of psychedelics in humans. They further suggest that neurometabolic changes in the posterior cingulate cortex, a key region within the default mode network, and increased connectivity between the anterior cingulate cortex and medial temporal lobe structures involved in emotion and memory potentially underlie the post-acute psychological effects of ayahuasca.}, bibtype = {article}, author = {Sampedro, Frederic and Revenga, Mario De La Fuente and Valle, Marta and Roberto, Natalia and Domínguez-Clavé, Elisabet and Elices, Matilde and Luna, Luís Eduardo and Crippa, José Alexandre S. and Hallak, Jaime Eduardo Cecilio and Araujo, Draulio Barros de and Friedlander, Pablo and Barker, Steven Andrew and Álvarez, Enrique and Soler, Joaquim and Pascual, Juan C. and Feilding, Amanda and Riba, Jordi}, journal = {International Journal of Neuropsychopharmacology}, number = {9} }
@misc{miyao_k._multicenter_2017, title = {A multicenter phase 2 study of empirical low-dose liposomal amphotericin {B} in patients with refractory febrile neutropenia}, url = {http://www.springer.com/west/home?SGWID=4-102-70-173744104-0&changeHeader=true}, abstract = {Invasive fungal infection (IFI) is a major life-threatening problem encountered by patients with hematological malignancies receiving intensive chemotherapy. Empirical antifungal agents are therefore important. Despite the availability of antifungal agents for such situations, the optimal agents and administration methods remain unclear. We conducted a prospective phase 2 study of empirical 1 mg/kg/day liposomal amphotericin B (L-AMB) in 80 patients receiving intensive chemotherapy for hematological malignancies. All enrolled patients were high-risk and had recurrent prolonged febrile neutropenia despite having received broad-spectrum antibacterial therapy for at least 72 hours. Fifty-three patients (66.3 \%) achieved the primary endpoint of successful treatment, thus exceeding the predefined threshold success rate. No patients developed IFI. The treatment completion rate was 73.8 \%, and only two cases ceased treatment because of adverse events. The most frequent events were reversible electrolyte abnormalities. We consider low-dose L-AMB to provide comparable efficacy and improved safety and cost-effectiveness when compared with other empirical antifungal therapies. Additional large-scale randomized studies are needed to determine the clinical usefulness of L-AMB relative to other empirical antifungal therapies. Copyright © 2016, The Japanese Society of Hematology.}, journal = {International Journal of Hematology}, author = {{Miyao K.} and {Sawa M.} and {Kurata M.} and {Suzuki R.} and {Sakemura R.} and {Sakai T.} and {Kato T.} and {Sahashi S.} and {Tsushita N.} and {Ozawa Y.} and {Tsuzuki M.} and {Kohno A.} and {Adachi T.} and {Watanabe K.} and {Ohbayashi K.} and {Inagaki Y.} and {Atsuta Y.} and {Emi N.}}, year = {2017}, keywords = {*amphotericin B lipid complex, *amphotericin B lipid complex/ae [Adverse Drug Reaction], *amphotericin B lipid complex/ct [Clinical Trial], *amphotericin B lipid complex/do [Drug Dose], *amphotericin B lipid complex/dt [Drug Therapy], *amphotericin B lipid complex/iv [Intravenous Drug Administration], *antifungal therapy, *febrile neutropenia, *febrile neutropenia/dt [Drug Therapy], *hematologic malignancy, *recurrent disease/dt [Drug Therapy], Pharmacokinetics, aciclovir, acute lymphoblastic leukemia/dt [Drug Therapy], acute myeloblastic leukemia/dt [Drug Therapy], adolescent, adult, adverse drug reaction, adverse drug reaction/si [Side Effect], aged, antibiotic therapy, antifungal therapy, antineoplastic agent/dt [Drug Therapy], article, cancer chemotherapy, chronic myeloid leukemia/dt [Drug Therapy], congenital malformation, controlled clinical trial, controlled study, cost effectiveness analysis, drug dose increase, drug efficacy, drug safety, drug therapy, electrolyte, febrile neutropenia/dt [Drug Therapy], female, high risk patient, human, infection prevention, intensive care, low drug dose, lymphoma/dt [Drug Therapy], major clinical study, male, multicenter study, multiple myeloma/dt [Drug Therapy], phase 2 clinical trial, prospective study, randomized controlled trial, recurrent disease/dt [Drug Therapy], safety, side effect, systemic mycosis/dt [Drug Therapy], treatment duration} }
@misc{sharp_w.g._systematic_2017, title = {A {Systematic} {Review} and {Meta}-{Analysis} of {Intensive} {Multidisciplinary} {Intervention} for {Pediatric} {Feeding} {Disorders}: {How} {Standard} {Is} the {Standard} of {Care}?}, url = {http://www.elsevier.com/inca/publications/store/6/2/3/3/1/1/index.htt}, abstract = {Objective To assess models of care and conduct a meta-analysis of program outcomes for children receiving intensive, multidisciplinary intervention for pediatric feeding disorders. Study design We searched Medline, PsycINFO, and PubMed databases (2000-2015) in peer-reviewed journals for studies that examined the treatment of children with chronic food refusal receiving intervention at day treatment or inpatient hospital programs. Inclusion criteria required the presentation of quantitative data on food consumption, feeding behavior, and/or growth status before and after intervention. Effect size estimates were calculated based on a meta-analysis of proportions. Results The systematic search yielded 11 studies involving 593 patients. Nine articles presented outcomes based on retrospective (nonrandomized) chart reviews; 2 studies involved randomized controlled trials. All samples involved children with complex medical and/or developmental histories who displayed persistent feeding concerns requiring formula supplementation. Behavioral intervention and tube weaning represented the most common treatment approaches. Core disciplines overseeing care included psychology, nutrition, medicine, and speech-language pathology/occupational therapy. The overall effect size for percentage of patients successfully weaned from tube feeding was 71\% (95\% CI 54\%-83\%). Treatment gains endured following discharge, with 80\% of patients (95\% CI 66\%-89\%) weaned from tube feeding at last follow-up. Treatment also was associated with increased oral intake, improved mealtime behaviors, and reduced parenting stress. Conclusions Results indicate intensive, multidisciplinary treatment holds benefits for children with severe feeding difficulties. Future research must address key methodological limitations to the extant literature, including improved measurement, more comprehensive case definitions, and standardization/examination of treatment approach. Copyright © 2016 Elsevier Inc.}, journal = {Journal of Pediatrics}, author = {{Sharp W.G.} and {Volkert V.M.} and {Scahill L.} and {McCracken C.E.} and {McElhanon B.}}, year = {2017}, keywords = {*child nutrition, *childhood disease/rh [Rehabilitation], *childhood disease/th [Therapy], *enteric feeding, *feeding behavior, *feeding difficulty, *feeding disorder/rh [Rehabilitation], *feeding disorder/th [Therapy], *health care quality, *treatment outcome, *weaning, Child, Medline, PsycINFO, article, clinical outcome, controlled study, effect size, enteric feeding, follow up, food intake, health program, hospital patient, hospitalization, human, human tissue, ideal body weight, medical record review, medicine, meta analysis, model, nutritional counseling, nutritional health, occupational therapy, parental stress, pediatric rehabilitation, priority journal, quantitative study, randomized controlled trial (topic), reinforcement, speech and language rehabilitation, speech disorder, standardization, study design, systematic review, weight reduction} }
@misc{kirton_a._transcranial_2017, title = {Transcranial direct current stimulation for children with perinatal stroke and hemiparesis}, url = {http://www.neurology.org}, abstract = {Objective: To determine whether the addition of transcranial direct current stimulation (tDCS) to intensive therapy increases motor function in children with perinatal stroke and hemiparetic cerebral palsy. Methods: This was a randomized, controlled, double-blind clinical trial. Participants were recruited from a population-based cohort with MRI-classified unilateral perinatal stroke, age of 6 to 18 years, and disabling hemiparesis. All completed a goal-directed, peer-supported, 2-week after-school motor learning camp (32 hours of therapy). Participants were randomized 1:1 to 1 mA cathodal tDCS over the contralesional primary motor cortex (M1) for the initial 20 minutes of daily therapy or sham. Primary subjective (Canadian Occupational Performance Measure [COPM]), objective (Assisting Hand Assessment [AHA]), safety, and secondary outcomes were measured at 1 week and 2 months after intervention. Analysis was by intention to treat. Results: Twenty-four participants were randomized (median age 11.8 +/- 2.7 years, range 6.7-17.8). COPM performance and satisfaction scores doubled at 1 week with sustained gains at 2 months (p {\textless} 0.001). COPM scores increased more with tDCS compared to sham control (p = 0.004). AHA scores demonstrated only mild increases at both time points with no tDCS effects. Procedures were safe and well tolerated with no decrease in either arm function or serious adverse events. Conclusion: TDCS trials appear feasible and safe in hemiparetic children. Lack of change in objective motor function may reflect underdosing of therapy. Marked gains in subjective function with tDCS warrant further study. ClinicalTrials.gov identifier: NCT02170285. Classification of evidence: This study provides Class II evidence that for children with perinatal stroke and hemiparetic cerebral palsy, the addition of tDCS to moderate-dose motor learning therapy does not significantly improve motor function as measured by the AHA. Copyright © 2016 American Academy of Neurology.}, journal = {Neurology}, author = {{Kirton A.} and {Ciechanski P.} and {Zewdie E.} and {Andersen J.} and {Nettel-Aguirre A.} and {Carlson H.} and {Carsolio L.} and {Herrero M.} and {Quigley J.} and {Mineyko A.} and {Hodge J.} and {Hill M.}}, year = {2017}, keywords = {*brain ischemia/th [Therapy], *cerebral palsy/th [Therapy], *cerebrovascular accident, *hemiparesis, *hemiparesis/th [Therapy], *perinatal morbidity, *transcranial direct current stimulation, Child, adolescent, adult, adverse drug reaction, adverse outcome, arm movement, article, assisting hand assessment, canadian occupational performance measure, cerebral palsy, classification, clinical article, clinical trial, controlled clinical trial, controlled study, cortical electrode, double blind procedure, female, human, intensive care, intention to treat analysis, male, motor learning, motor performance, neurologic disease assessment, nuclear magnetic resonance imaging, patient safety, peer group, population based case control study, primary motor cortex, priority journal, randomized controlled trial, safety, satisfaction, school child, side effect} }
@article{mccarthy_pash_2016, title = {{PASH} syndrome: {A} case report with bony destruction}, volume = {74}, issn = {0190-9622}, url = {http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L72275278}, abstract = {A 44-year-old man with severe refractory hidradenitis suppurativa (HS) was admitted with cachexia and fatigue. He had a longstanding history of HS, beginning in childhood, cutaneous ulceration and acne. Since the age of 24 he had recurrent abscesses in the axillae and anogenital skin as well as cutaneous ulceration on the penile shaft, abdomen, forearms and thighs consistent with pyoderma gangrenosum (PG). On examination there was rope like dermal thickening of skin on the buttocks and perineum with florid erythema and multiple fistula openings with purulent discharge consistent with Hurley stage III disease. Large atrophic telangiectatic scars were present on the abdomen and thighs suggestive of quiescent pyoderma gangrenosum. CT scan of thorax, abdomen and pelvis showed lytic destruction of the sacrum most likely reflecting chronic osteomyelitis from direct extension of the inflammatory process through subcutaneous tissue and bone into the presacral space. The patient was treated with meropenem 1 g/day for seven days with marked improvement in HS. Inflammatory markers returned to normal and infliximab (0.5 mg/kg) was commenced to maintain remission. Hidradenitis suppurativa is a chronic autoinflammatory disorder characterized by acneiform follicular occlusion and inflammation of the terminal follicular epithelium in apocrine gland bearing skin that leads to relapsing purulent infections, scarring and sinus formation. The clinical presentation of severe HS, acne, pilonidal sinus and PG may be consistent with the recently recognised PASH syndrome. Our patient has never had joint symptoms suggestive of arthritis and therefore clinically does not fit with previously described PAPA (pyogenic sterile arthritis, PG, acne) or PAPASH (PAPA plus HS) syndromes. Imaging plays an important role in assessing extent of disease, characterizing active lesions and recognizing complications. To our knowledge this is the first case report of bony destruction of the coccyx by direct extension of HS.}, number = {5}, journal = {Journal of the American Academy of Dermatology}, author = {McCarthy, S. and Foley, C. and Dvorakova, V. and Quinlan, C. and Murphy, M. and Maher, M.}, year = {2016}, keywords = {American, abdomen, abscess, acne, apocrine gland, arthritis, autoinflammatory disease, axilla, bone, buttock, cachexia, case report, childhood, chronic osteomyelitis, coccygeal bone, computer assisted tomography, dermatology, epithelium, erythema, examination, fatigue, fistula, forearm, human, imaging, infection, inflammation, infliximab, male, marker, meropenem, occlusion, patient, pelvis, perineum, pilonidal sinus, pyoderma gangrenosum, remission, sacrum, scar, scar formation, skin, subcutaneous tissue, suppurative hidradenitis, thigh, thorax, ulcer}, pages = {AB65} }
@misc{ferre_c.l._caregiver-directed_2016, title = {Caregiver-directed home-based intensive bimanual training in young children with unilateral spastic cerebral palsy: {A} randomized trial}, url = {http://www.wiley.com/bw/journal.asp?ref=0012-1622&site=1}, abstract = {Aim: To examine the efficacy of caregiver-directed, home-based intensive bimanual training in children with unilateral spastic cerebral palsy (USCP) using a randomized control trial. Method: Twenty-four children (ages 2y 6mo-10y 1mo; 10 males, 14 females) performed home-based activities directed by a caregiver for 2 hours per day, 5 days per week, for 9 weeks (total=90h). Cohorts of children were age-matched into groups and randomized to receive home-based hand-arm bimanual intensive therapy (H-HABIT; n=12) or lower-limb functional intensive training (LIFT-control; n=12). Caregivers were trained before the intervention and supervised remotely via telerehabilitation. Dexterity and bimanual hand function were assessed using the Box and Blocks test (BBT) and the Assisting Hand Assessment (AHA) respectively. Caregiver perception of functional goals was measured using the Canadian Occupational Performance Measure (COPM). Results: H-HABIT showed greater improvement on the BBT compared to LIFT-control and no improvement on the AHA. H-HABIT demonstrated significant improvement in COPM-Performance compared to LIFT-control and both groups showed equal improvement in COPM-Satisfaction. Interpretation: H-HABIT improved dexterity and performance of functional goals, but not bimanual performance, in children with USCP compared to a control group receiving intervention of equal intensity/duration that also controlled for increased caregiver attention. Home-based models provide a valuable, family-centered approach to achieve increased treatment intensity. Copyright © 2016 Mac Keith Press.}, journal = {Developmental Medicine and Child Neurology}, author = {{Ferre C.L.} and {Brandao M.} and {Surana B.} and {Dew A.P.} and {Moreau N.G.} and {Gordon A.M.}}, year = {2016}, keywords = {*caregiver, *cerebral palsy, Child, attention, clinical article, clinical trial, control group, controlled clinical trial, controlled study, endogenous compound, female, hand function, human, intensive care, lower limb, male, model, perception, preschool child, randomized controlled trial, satisfaction, telerehabilitation} }
@article{martinez-rios_sterile_2016, title = {Sterile pyogenic arthritis pyoderma gangrenosum, and acne ({PAPA}) syndrome: {Musculoskeletal} imaging findings and common differential diagnosis in children}, volume = {46}, issn = {1432-1998}, url = {http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L72287938}, abstract = {Purpose or Case Report: Sterile pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA syndrome) is a rare autosomal dominant inherited entity due to a missense mutation in the proline serine threonine phosphatase-interacting protein 1 (PSTPIP1/CD2BP1) gene, characterized by typical recurrent episodes of sterile pyogenic arthritis, either spontaneous or following a trauma, and skin manifestations characterized by pyoderma gangrenosum and acne. The articular manifestation is seen in the first decade of life, where most of the initial episodes are treated as septic arthritis. Cutaneous manifestations appear in early adulthood. Although uncommon, the potential therapeutic and clinical implications due to the rapidly destructive nature of PAPA syndrome warrant a prompt diagnosis. We present two unrelated pediatric patients from different institutions with genetically confirmed PAPA syndrome. The purpose of this study was to illustrate the musculoskeletal radiologic spectrum of findings of PAPA syndrome, and to discuss the differential diagnostic entities commonly seen in children. A second objective was to review the clinical and laboratory findings that allow diagnosis of PAPA syndrome Methods \& Materials: Patients' consent were obtained. We reviewed the imaging features of PAPA syndrome in different imaging modalities including plain radiograph, ultrasound, and magnetic resonance imaging, and we included representative cases of more common musculoskeletal diagnostic entities that present with similar imaging and clinical features in children Results: Many of the imaging features seen in PAPA syndrome overlap with other clinical conditions including septic arthritis, osteomyelitis and juvenile idiopathic arthritis, including joint effusion, synovial thickening and extensive soft tissue swelling Conclusions: PAPA syndrome would not be suspected initially based on imaging appearance alone, but should be considered in cases of recurrent septic arthritis or in those demonstrating skin manifestations. Radiologists familiarization with the syndrome may allow them to recognize the condition earlier in its course.}, number = {(Jariwala M.; Highmore K.; Duffy K.W.; Laxer R.; Stimec J.)}, journal = {Pediatric Radiology}, author = {Martinez-Rios, C. and Jariwala, M. and Highmore, K. and Duffy, K.W. and Laxer, R. and Stimec, J.}, year = {2016}, keywords = {PAPA syndrome, X ray film, acne, adulthood, autosomal dominant inheritance, bacterial arthritis, case report, child, clinical feature, diagnosis, differential diagnosis, edema, gene, human, imaging, injury, joint effusion, juvenile rheumatoid arthritis, laboratory, missense mutation, nuclear magnetic resonance imaging, osteomyelitis, patient, phosphatase, proline, pyoderma gangrenosum, radiologist, radiology, serine, skin manifestation, soft tissue, synapsin I, threonine, ultrasound}, pages = {S246} }
@misc{ratnayake_a._pharmacokinetics_2016, title = {Pharmacokinetics and pharmacodynamics of albuterol multidose dry powder inhaler and albuterol hydrofluoroalkane in children with asthma}, url = {http://www.ingentaconnect.com/search/download?pub=infobike%3a%2f%2focean%2faap%2f2016%2f00000037%2f00000005%2fart00011&mimetype=application%2fpdf&exitTargetId=1473325081442}, abstract = {Background: Many children struggle with the use of albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. Objective: To compare the pharmacokinetics (PK), pharmacodynamics (PD), and tolerability of albuterol MDPI and albuterol HFA after a single inhaled dose in children with asthma. Methods: This single-center, open-label, two-period crossover study randomized children to albuterol MDPI or HFA 180 mug on two treatment days with a 4- to 14-day washout. Plasma albuterol concentrations were measured before the dose and up to 10 hours after the dose to determine the primary PK values of area under the plasma concentration-versus-time curve from time 0 to the last measurable concentration (AUC0-t), maximum observed concentration (Cmax), and AUC from time 0 extrapolated to infinity (AUC0-inf). Heart rate and blood pressure before the dose and after the dose were monitored for PD effects, and adverse events (AE) were monitored for overall safety. Results: Fifteen children, ages 6-11 years, were included (PK, n = 13 for time to Cmax and terminal half-life of elimination; n = 12 for AUC and Cmax due to incomplete data). AUC0-t (geometric mean ratio [GMR] 1.056 [90\% confidence interval \{CI\}, 0.88 -1.268]) and AUC0-inf (GMR 0.971 [90\% CI, 0.821-1.147]) were comparable between treatments. Cmax was larger for albuterol MDPI versus HFA (GMR 1.340 [90\% CI, 1.098 -1.636]). PD parameters between the treatments were comparable. No deaths, serious AEs, treatment-emergent AEs, or withdrawals due to AEs were reported for either treatment. Conclusion: Albuterol MDPI and albuterol HFA had comparable PK and PD in children after a single 180-mug dose. Copyright ©2016, OceanSide Publications, Inc., U.S.A.}, journal = {Allergy and Asthma Proceedings}, author = {{Ratnayake A.} and {Taveras H.} and {Iverson H.} and {Shore P.}}, year = {2016}, keywords = {*albuterol hydrofluoroalkane/ae [Adverse Drug Reaction], *albuterol hydrofluoroalkane/cm [Drug Comparison], *albuterol hydrofluoroalkane/ct [Clinical Trial], *albuterol hydrofluoroalkane/dt [Drug Therapy], *albuterol hydrofluoroalkane/ih [Inhalational Drug Administration], *albuterol hydrofluoroalkane/pk [Pharmacokinetics], *antiasthmatic agent/ae [Adverse Drug Reaction], *antiasthmatic agent/cm [Drug Comparison], *antiasthmatic agent/ct [Clinical Trial], *antiasthmatic agent/dt [Drug Therapy], *antiasthmatic agent/ih [Inhalational Drug Administration], *antiasthmatic agent/pk [Pharmacokinetics], *asthma, *asthma/dt [Drug Therapy], *dry powder inhaler, *dry powder inhaler/ct [Clinical Trial], *dry powder inhaler/dc [Device Comparison], *inhaler, *inhaler/ct [Clinical Trial], *inhaler/dc [Device Comparison], *multidose dry powder inhaler, *multidose dry powder inhaler/ct [Clinical Trial], *multidose dry powder inhaler/dc [Device Comparison], *pharmacodynamics, *salbutamol, *salbutamol/ae [Adverse Drug Reaction], *salbutamol/cm [Drug Comparison], *salbutamol/cr [Drug Concentration], *salbutamol/ct [Clinical Trial], *salbutamol/dt [Drug Therapy], *salbutamol/ih [Inhalational Drug Administration], *salbutamol/pk [Pharmacokinetics], Child, Pharmacokinetics, adverse drug reaction, area under the curve, asthma/dt [Drug Therapy], blood pressure, blood pressure monitoring, clinical article, clinical trial, conference paper, confidence interval, controlled clinical trial, controlled study, crossover procedure, death, drug blood level, drug efficacy, drug elimination, drug half life, drug monitoring, drug safety, drug withdrawal, female, fluorinated hydrocarbon, half life time, heart rate, human, human tissue, male, maximum plasma concentration, pharmacodynamics, phase 1 clinical trial, plasma concentration-time curve, preschool child, randomized controlled trial, safety, side effect, time to maximum plasma concentration, unclassified drug, unspecified side effect/si [Side Effect]} }
@incollection{godfrey_end--life_2016, title = {End-of-life issues for {LGBT} elders}, url = {http://uml.idm.oclc.org/login?url=https://search.proquest.com/docview/1862755771?accountid=14569}, abstract = {This chapter explores the end-of-life issues and what makes end-of-life issues different for LGBT adults. The laws and policies relating to end-of-life have many presumptions that favor family, specifically biological or adoptive family and family from marriage. These presumptions impact health care decision-making, visitation policies, health insurance, health benefits, retirement plans, taxation, and inheritance rules. The expansion of same-sex marriage is changing this picture, but a great deal of work remains to be done. Societal homophobia impacts access to care, relationship recognition, and even funeral planning. Ageism is common in some parts of the LGBT community, casting a shadow over many LGBT elders. Many of die current generation of LGBT elders survived the darkest days of AIDS and HIV, and this experience influences their views on aging and end-of-life. (PsycINFO Database Record (c) 2017 APA, all rights reserved) (Source: chapter)}, language = {English}, booktitle = {Handbook of {LGBT} elders: {An} interdisciplinary approach to principles, practices, and policies}, publisher = {Springer Science + Business Media, New York, NY}, author = {Godfrey, David}, editor = {Harley, Debra A. and Teaster, Pamela B.}, year = {2016}, note = {DOI: 10.1007/978-3-319-03623-6\_22}, keywords = {3370:Health \& Mental Health Services, Adulthood (18 yrs \& older), Age Discrimination, Aged (65 yrs \& older), Ageism, Clinical Case Study, Decision Making, Disabilities, Female, Guardianship, Health Care Services, Human, Incapacity, Inheritance, Male, Palliative Care, Presumptions, Professional Ethics, Psychology: Professional \& Research, Quality of Life, Surrogate, bookitem}, pages = {439--454, Chapter xviii, 691 Pages} }
@incollection{harley_impact_2016, title = {Impact of healthcare reform on {LGBT} elders}, url = {http://uml.idm.oclc.org/login?url=https://search.proquest.com/docview/1862755097?accountid=14569}, abstract = {The purpose of this chapter was to examine the impact of healthcare reform in the USA on LGBT elders, especially the Affordable Care Act (ACA). Attention is given to health disparities and coming out risk factors for LGBT elders, health systems challenges for LGBT elders, advantages and disadvantages of healthcare reform on LGBT elders, and future directions of healthcare reform in the USA. Where appropriate, discussion from an international perspective is included, especially Canada and the UK. It is not the intent of this chapter to endorse any point of view over the other or to be advisory about healthcare issues. The intent is to present multiple perspectives concerning the benefits and debates of healthcare reform on seniors, especially LGBT elders. (PsycINFO Database Record (c) 2017 APA, all rights reserved) (Source: chapter)}, language = {English}, booktitle = {Handbook of {LGBT} elders: {An} interdisciplinary approach to principles, practices, and policies}, publisher = {Springer Science + Business Media, New York, NY}, author = {Harley, Debra A.}, editor = {Harley, Debra A. and Teaster, Pamela B.}, year = {2016}, note = {DOI: 10.1007/978-3-319-03623-6\_19}, keywords = {3370:Health \& Mental Health Services, Adulthood (18 yrs \& older), Aged (65 yrs \& older), Aging, Cross Cultural Differences, Empirical Study, Female, Health Care Reform, Health Disparities, Healthcare reform, Human, LGBT elders' health, LGBT health disparities, Longitudinal Study, Male, Psychology: Professional \& Research, Quantitative Study, Retrospective Study, Risk Factors, Transgender, bookitem}, pages = {375--389, Chapter xviii, 691 Pages} }
@misc{bannon_l._impact_2016, title = {Impact of non-pharmacological interventions on prevention and treatment of delirium in critically ill patients: {Protocol} for a systematic review of quantitative and qualitative research}, url = {http://www.systematicreviewsjournal.com/}, abstract = {Background: Critically ill patients have an increased risk of developing delirium during their intensive care stay. To date, pharmacological interventions have not been shown to be effective for delirium management but non-pharmacological interventions have shown some promise. The aim of this systematic review is to identify effective non-pharmacological interventions for reducing the incidence or the duration of delirium in critically ill patients. Methods: We will search MEDLINE, EMBASE, CINAHL, Web of Science, AMED, psycINFO and the Cochrane Library. We will include studies of critically ill adults and children. We will include randomised trials and controlled trials which measure the effectiveness of one or more non-pharmacological interventions in reducing incidence or duration of delirium in critically ill patients. We will also include qualitative studies that provide an insight into patients and their families' experiences of delirium and non-pharmacological interventions. Two independent reviewers will assess studies for eligibility, extract data and appraise quality. We will conduct meta-analyses if possible or present results narratively. Qualitative studies will also be reviewed by two independent reviewers, and a specially designed quality assessment tool incorporating the CASP framework and the POPAY framework will be used to assess quality. Discussion: Although non-pharmacological interventions have been studied in populations outside of intensive care units and multicomponent interventions have successfully reduced incidence and duration of delirium, no systematic review of non-pharmacological interventions specifically targeting delirium in critically ill patients have been undertaken to date. This systematic review will provide evidence for the development of a multicomponent intervention for delirium management of critically ill patients that can be tested in a subsequent multicentre randomised trial. Systematic review registration: PROSPERO CRD42015016625 Copyright © 2016 Bannon et al.}, journal = {Systematic Reviews}, author = {{Bannon L.} and {McGaughey J.} and {Clarke M.} and {McAuley D.F.} and {Blackwood B.}}, year = {2016}, keywords = {*critical illness, *critically ill patient, *delirium, *delirium/pc [Prevention], *delirium/th [Therapy], *intensive care unit, *medical procedures, *qualitative research, *registration, Child, Cinahl, Cochrane Library, Embase, Medline, PsycINFO, Web of Science, adult, article, bright light therapy, cognitive therapy, controlled clinical trial, critically ill patient, ear plug, education, exercise, extract, eye mask, family study, human, incidence, intensive care unit, lighting control, mask, meta analysis, music therapy, noise reduction, orientation, outcome assessment, physiotherapy, priority journal, publication, qualitative research, quality control, quantitative study, randomized controlled trial, randomized controlled trial (topic), risk factor, scientific literature, sensitivity analysis, systematic review} }
@inProceedings{ title = {FreeSense: Indoor Human Identification with Wi-Fi Signals}, type = {inProceedings}, year = {2016}, identifiers = {[object Object]}, keywords = {80211,analysis,analysissensorsshapetime,analysissmart,analysiswireless,biometric,channelscsi,characteristicschannel,component,computer,discrete,environmentdynamic,environmentfeature,extractionieee,home,human,identificationdtw,identificationmotion,identificationprincipal,information,interactionindoor,lanwireless,locomotionprincipal,navigationprincipal,patternnonintrusive,rf,series,seriescsi,seriesdiscrete,shape,signalbody,standardlegged,state,techniquedwtfreesensepcawi-fi,techniquehuman-computer,time,transformdomestic,transformshuman,warping,waveform-based,wavelet}, pages = {1-7}, websites = {http://dx.doi.org/10.1109/GLOCOM.2016.7841847}, publisher = {IEEE}, id = {973cb24b-ec5f-3be9-a1e4-da55d505d19a}, created = {2018-07-12T21:32:38.958Z}, file_attached = {false}, profile_id = {f954d000-ce94-3da6-bd26-b983145a920f}, group_id = {b0b145a3-980e-3ad7-a16f-c93918c606ed}, last_modified = {2018-07-12T21:32:38.958Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {xin2016}, source_type = {inproceedings}, private_publication = {false}, bibtype = {inProceedings}, author = {Xin, T and Guo, B and Wang, Z and Li, M and Yu, Z and Zhou, X}, booktitle = {Global Communications Conference (GLOBECOM)} }
@article{bradleyPerceivedAddictionInternet2016, title = {Perceived Addiction to Internet Pornography among Religious Believers and Nonbelievers.}, author = {Bradley, David F. and Grubbs, Joshua B. and Uzdavines, Alex and Exline, Julie J. and Pargament, Kenneth I.}, year = {2016}, month = apr, journal = {Sexual Addiction \& Compulsivity}, volume = {23}, number = {2/3}, pages = {225--243}, issn = {1072-0162}, doi = {10.1080/10720162.2016.1162237}, abstract = {The article presents an study on the relationship between religiousness and perceived addiction to Internet pornography among religious believers and nonbelievers. It discusses the definition of nonbelief, the connection of perceived addiction to various distress indicators and findings indicating increased perceived addiction among religious believers, self-indication as a predictor of perceived addiction and the relation of perceived addiction to psychological distress in both study groups.}, copyright = {All rights reserved}, keywords = {Addiction,Human,Internet,internet pornography,Internet Pornography Addiction,INTERNET pornography addiction,Perceived addiction,Pornography,psychological distress,PSYCHOLOGICAL stress,RELIGION,Religion and Religions -- United States,Religious Beliefs,religious believers,Self Assessment,SELF-evaluation,Spirituality,SPIRITUALITY,Stress; Psychological,United States,UNITED States}, file = {/Volumes/GoogleDrive/My Drive/Manuscripts/Zotero/storage/CPK6FF34/bradley2016.pdf} }
@incollection{pittman_magic_2016, title = {The magic of aging in the urban environment}, url = {http://uml.idm.oclc.org/login?url=https://search.proquest.com/docview/1769711053?accountid=14569}, abstract = {This chapter provides an entry into the section on aging among African Americans in urban environments. Briefly discussed in this section are a broader portrait of older African American adults living in urban communities and selected issues of importance such as caregiving, intergenerational dynamics of urban families, and coping with grief and loss in urban communities. Although not exhaustive, these selections are intended to initiate further discussion on not only people and contextual challenges but also the strengths and powers of people in contexts, in which lies the magic of aging in urban communities. Appropriately conceptualizing social work practice with the aging African American population in the urban environment is critical for promoting quality of life. That is, as discussed by Simpson, Giunta, and Vakalahi, older adults represent intersectional and multidimensional lived experiences, cultures, histories, and sociopolitical worldviews that challenge mainstream linear approaches and theories. (PsycINFO Database Record (c) 2016 APA, all rights reserved) (Source: chapter)}, language = {English}, booktitle = {Social work practice with {African} {Americans} in urban environments}, publisher = {Springer Publishing Co, New York, NY}, author = {Pittman, Margaret E. and Scheidt, Leeza M. and Munford, Merissa R. and Vakalahi, Halaevalu F. Ofahengaue}, editor = {Wells-Wilbon, Rhonda and McPhatter, Anna R. and Vakalahi, Halaevalu F. Ofahengaue}, year = {2016}, keywords = {2860:Gerontology, 3373:Community \& Social Services, Adulthood (18 yrs \& older), African Americans, Aged (65 yrs \& older), Aging, Blacks, Caregivers, Coping Behavior, Family, Grief, Human, Intergenerational Relations, Psychology: Professional \& Research, Social Casework, US, Urban Environments, aging, bookitem, caregiving, coping, family, grief, intergenerational dynamics, social work, urban environments}, pages = {225--234, Chapter xxv, 457 Pages} }
@misc{cherubini_v._long-acting_2016, title = {Long-acting {Insulin} {Analogs} {Effect} on gh/igf {Axis} of {Children} with {Type} 1 {Diabetes}: {A} {Randomized}, {Open}-label, {Two}-period, {Cross}-over {Trial}}, url = {http://www.thieme-connect.com/ejournals/toc/eced}, abstract = {Background: Growth hormone (GH) secretion is increased in pre-pubertal children with type 1 diabetes and GH excess produces insulin resistance. Early-morning insulinopenia contributes to lower insulin-like growth factor (IGF-I) levels and to GH hypersecretion. Objective: To evaluate differences in GH/IGF-I axis of pre-pubertal children with type 1 diabetes treated with glargine or detemir as long-acting insulin analogues, which was the main outcome measure, and to compare insulin effects in obtaining good metabolic control. Subjects: Children with type 1 diabetes. Methods: This was a 32-week, randomized, open-label, two-period, cross-over comparison between bedtime glargine and twice-daily detemir insulin, involving pre-pubertal children in care at a diabetes pediatric centre. After a 8-week-run-in period subjects were randomized to bedtime glargine or twice-daily detemir insulin administration. After a 12-week period treatments were inverted and continued for additional 12 weeks. Results: Overall, 15 pre-pubertal children (53.3\% males, mean age 8.6+/-1.5 years, duration of diabetes 4.2+/-1.5 years) completed the study. Groups did not differ for GH/IGF axis and HbA1c levels. Treatment with glargine was associated with lower fasting glucose values than treatment with detemir (8.1+/-1.5 vs. 8.2+/-1.7 mmol/L, p=0.01). Incidence rate of hypoglycemia was not different between insulin treatments (IRR=1.18, 95\%CI 1.00-1.38; p=0.07). Detemir treatment was associated with a higher increase in body weight (p=0.008) and height (p=0.02) when compared with glargine. Conclusion: Detemir and glargine not show significant differential effects on the GH/IGFI axis. The greater weight gain and height associated with detemir treatment, apparently not related to the level of pubertal growth, deserve further investigation. Copyright © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart New York.}, journal = {Experimental and Clinical Endocrinology and Diabetes}, author = {{Cherubini V.} and {Pintaudi B.} and {Iannilli A.} and {Pambianchi M.} and {Ferrito L.} and {Nicolucci A.}}, year = {2016}, keywords = {*growth hormone blood level, *growth hormone/ec [Endogenous Compound], *insulin dependent diabetes mellitus, *insulin dependent diabetes mellitus/dt [Drug Therapy], *insulin detemir/cm [Drug Comparison], *insulin detemir/ct [Clinical Trial], *insulin detemir/dt [Drug Therapy], *insulin glargine/cm [Drug Comparison], *insulin glargine/ct [Clinical Trial], *insulin glargine/dt [Drug Therapy], *long acting insulin, *protein blood level, *somatomedin/ec [Endogenous Compound], Child, article, bedtime dosage, blood glucose monitoring, body height, body weight, clinical article, clinical trial, comparative effectiveness, controlled clinical trial, controlled study, crossover procedure, diabetic patient, female, glucose blood level, glucose/ec [Endogenous Compound], growth hormone, height, hemoglobin A1c, hemoglobin A1c/ec [Endogenous Compound], hemoglobin blood level, human, hypoglycemia, incidence, insulin dependent diabetes mellitus/dt [Drug Therapy], insulin detemir, insulin glargine, insulin treatment, male, open study, pediatric hospital, prepuberty, priority journal, randomized controlled trial, somatomedin C, weight gain} }
@misc{clarke_s.l.n._juvenile_2016, title = {Juvenile idiopathic arthritis-associated uveitis}, url = {http://www.ped-rheum.com/}, abstract = {Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, with JIA-associated uveitis its most common extra-articular manifestation. JIA-associated uveitis is a potentially sight-threatening condition and thus carries a considerable risk of morbidity. The aetiology of the condition is autoimmune in nature with the predominant involvement of CD4+ T cells. However, the underlying pathogenic mechanisms remain unclear, particularly regarding interplay between genetic and environmental factors. JIA-associated uveitis comes in several forms, but the most common presentation is of the chronic anterior uveitis type. This condition is usually asymptomatic and thus screening for JIA-associated uveitis in at-risk patients is paramount. Early detection and treatment aims to stop inflammation and prevent the development of complications leading to visual loss, which can occur due to both active disease and burden of disease treatment. Visually disabling complications of JIA-associated uveitis include cataracts, glaucoma, band keratopathy and macular oedema. There is a growing body of evidence for the early introduction of systemic immunosuppressive therapies in order to reduce topical and systemic glucocorticoid use. This includes more traditional treatments, such as methotrexate, as well as newer biological therapies. This review highlights the epidemiology of JIA-associated uveitis, the underlying pathogenesis and how affected patients may present. The current guidelines and criteria for screening, diagnosis and monitoring are discussed along with approaches to management. Copyright © 2016 Clarke et al.}, journal = {Pediatric Rheumatology}, author = {{Clarke S.L.N.} and {Sen E.S.} and {Ramanan A.V.}}, year = {2016}, keywords = {*juvenile rheumatoid arthritis, *juvenile rheumatoid arthritis/di [Diagnosis], *juvenile rheumatoid arthritis/dt [Drug Therapy], *juvenile rheumatoid arthritis/ep [Epidemiology], *juvenile rheumatoid arthritis/et [Etiology], *uveitis/di [Diagnosis], *uveitis/dt [Drug Therapy], *uveitis/ep [Epidemiology], *uveitis/et [Etiology], CD4 T lymphocyte, CD4 antigen/ec [Endogenous Compound], CD8 antigen/ec [Endogenous Compound], CD8+T lymphocyte, Child, HLA B27 antigen/ec [Endogenous Compound], HLA DPB1 antigen/ec [Endogenous Compound], HLA DR1 antigen/ec [Endogenous Compound], HLA DR5 antigen/ec [Endogenous Compound], HLA DRB1 antigen/ec [Endogenous Compound], abatacept/ct [Clinical Trial], abatacept/dt [Drug Therapy], adalimumab/ae [Adverse Drug Reaction], adalimumab/cm [Drug Comparison], adalimumab/ct [Clinical Trial], adalimumab/dt [Drug Therapy], azathioprine/ae [Adverse Drug Reaction], azathioprine/dt [Drug Therapy], biological product/ct [Clinical Trial], biological product/dt [Drug Therapy], blindness, bone marrow suppression/si [Side Effect], cataract, cataract/co [Complication], cataract/si [Side Effect], cataract/su [Surgery], childhood, clinical feature, clinical study, corticosteroid/ae [Adverse Drug Reaction], corticosteroid/dt [Drug Therapy], cyclopentolate/dt [Drug Therapy], cycloplegic agent/dt [Drug Therapy], cyclosporin A/ae [Adverse Drug Reaction], cyclosporin A/dt [Drug Therapy], dexamethasone sodium phosphate/dt [Drug Therapy], diagnosis, disease association, drug substitution, drug withdrawal, environmental factor, etanercept/cm [Drug Comparison], etanercept/ct [Clinical Trial], etanercept/dt [Drug Therapy], ethnicity, eye pain, eye redness, gastrointestinal symptom/si [Side Effect], glaucoma, glaucoma/co [Complication], glaucoma/su [Surgery], glucocorticoid, glucocorticoid/ae [Adverse Drug Reaction], glucocorticoid/dt [Drug Therapy], groups by age, hair loss/si [Side Effect], headache, hematologic disease/si [Side Effect], human, hypertension/si [Side Effect], immunosuppressive agent/dt [Drug Therapy], immunosuppressive treatment, incidence, infection/si [Side Effect], infliximab/cm [Drug Comparison], infliximab/ct [Clinical Trial], infliximab/dt [Drug Therapy], iridocyclitis, juvenile rheumatoid arthritis/dt [Drug Therapy], keratopathy, kidney dysfunction/si [Side Effect], leflunomide/cm [Drug Comparison], leflunomide/dt [Drug Therapy], leukopenia/si [Side Effect], lipodystrophy/si [Side Effect], liver dysfunction/si [Side Effect], liver enzyme/ec [Endogenous Compound], macular edema, meta analysis (topic), methotrexate, methotrexate/ae [Adverse Drug Reaction], methotrexate/cb [Drug Combination], methotrexate/cm [Drug Comparison], methotrexate/ct [Clinical Trial], methotrexate/dt [Drug Therapy], methylprednisolone/dt [Drug Therapy], monitoring, morbidity, mycophenolate mofetil/ae [Adverse Drug Reaction], mycophenolate mofetil/cb [Drug Combination], mycophenolate mofetil/dt [Drug Therapy], nausea/si [Side Effect], pathogenesis, patient monitoring, phacoemulsification, photophobia, placebo, practice guideline, prednisolone acetate/dt [Drug Therapy], prevalence, prevention, priority journal, prognosis, randomized controlled trial (topic), review, risk assessment, screening, screening test, sex difference, systematic review (topic), tacrolimus/ae [Adverse Drug Reaction], tacrolimus/dt [Drug Therapy], topical drug administration, trabeculectomy, treatment failure, tropicamide/dt [Drug Therapy], unindexed drug, unspecified side effect/si [Side Effect], uveitis/dt [Drug Therapy]} }
@misc{hallet_c._two_2016, title = {Two different techniques of facial mask induction of anesthesia in children provide identical intubation conditions despite different anesthetic depth}, url = {http://www.arsmb-kvbmg.be/ramsb/contact.html}, abstract = {Background: Sevoflurane induction in children is performed using different techniques. Constricted, centered, and symmetrical pupils (CCSP) are classically the endpoint to be achieved before laryngoscopy is performed. Objectives: We investigated whether two different inhalation induction techniques with the same clinical end-point provided similar intubating conditions and comparable depth of anesthesia as assessed by the Bispectral Index (BIS). Methods: Following IRB approval, and informed parental consent, 20 children were recruited. They were scheduled for general anesthesia with tracheal intubation, and randomly assigned to Group 1, where the practitioner used 6\% inspired sevoflurane in 50\% O2/N2O, and no manually assisted ventilation, or Group 2, where inspired sevoflurane was 8\% in 50\% O2/N2O, and ventilation was manually supported upon loss of consciousness. BIS values were blinded. Laryngoscopy was performed after CCSP. Intubation conditions scoring was based on jaw relaxation (mobile = 1, partially mobile = 2, fixed = 3), position of vocal cords (open = 1, half-closed = 2, closed = 3), and cough (no cough = 1,1 or 2 coughing efforts = 2, persistent coughing = 3). A total score {\textgreater}3 corresponded to non-optimal conditions. Results: Upon CCSP, BIS values were significantly lower in Group 1 [mean (SD): 30 (8) - 48 (18), p {\textless} 0.001], despite significantly higher end-tidal sevoflurane concentration in Group 2 [mean (SD): 5.0 (0.7) - 6.2 (0.5); p {\textless} 0.001]. Time to CCSP was slightly shorter in Group 2. Intubation conditions were always optimal except for one patient of Group 1. Discussion: Both induction techniques achieve good intubating conditions. Possible explanations for the between-group BIS difference include variable appreciation of the CCSP endpoint, different induction lengths or sevoflurane equilibration times, or sevoflurane-induced increase in electroencephalogram power. A better indicator of the best time to intubate is needed to avoid too deep anesthesia in children. Copyright © Ada Anaesthesiologica Belgica, 2016.}, journal = {Acta Anaesthesiologica Belgica}, author = {{Hallet C.} and {Venneman I.} and {Hans G.} and {Bonhomme V.}}, year = {2016}, keywords = {*anesthesia induction, *anesthesia level, *bispectral index, *endotracheal intubation, *face, *pediatric face mask, *pediatric face mask/ct [Clinical Trial], *sevoflurane, Child, anesthesiology monitoring device, article, assisted ventilation, bispectral index, clinical article, clinical trial, controlled clinical trial, controlled study, coughing, double blind procedure, endotracheal tube cuff, exposure, general anesthesia, human, intermethod comparison, jaw, laryngoscopy, leisure, manual ventilation, mechanical ventilator, oxygen, parental consent, physician, prospective study, randomized controlled trial, rebreathing device, sevoflurane/ih [Inhalational Drug Administration], single blind procedure, unconsciousness, vocal cord} }
@misc{vassiliou_l.-v._impact_2016, title = {Impact of malignant cerebral artery infarction guidelines on the profile of the cranioplasty service}, abstract = {Background: Early decompressive craniectomy (DC) for malignant middle cerebral artery (MCA) infarction leads to improved survival, as demonstrated by three multicenter randomized controlled trials (DECIMAL, DESTINY, HAMLET). The survivors of a malignant MCA stroke manifest complex medical and neurological problems along with extensive calvarial defects that require cranioplasty.Aims and methodology: This is a retrospective study from a tertiary referral center. We assess the impact of the new MCA stroke guidelines in the number of craniectomy patients referred for cranioplasty. We analyze the postoperative course of this specific subgroup of patients and we compare it against the contemporary cranioplasties population (craniectomy defects following traumatic brain injury, hemorrhagic strokes, oncological ablation, or infections).Results: Data of 78 patients (46 male, 32 female) referred for cranioplasty were analyzed over a 2-year period. Mean age was 42 years (range 12-73). In a representative year (2011), prior to the new stroke guidelines, only 4/30 (13\%) cases had DC for malignant MCA infarction, whereas subsequently in 2015, 15/48 (31\%) of the cranioplasty candidates had previously suffered malignant MCA infarction. Whilst the majority of patients were discharged on the third postoperative day and the overall complication rate was low (7\%), the postoperative course of post-malignant MCA patients was often complicated due to associated medical comorbidities leading to prolonged hospital stay.Conclusion: Reconstruction of the cranial vault in patients post-craniectomy for malignant MCA infarction poses complex perioperative challenges. The increasing demand for cranioplasty in this subset of patients necessitates appropriate neuro-intensive care infrastructure and expertise.}, journal = {British Journal of Oral and Maxillofacial Surgery}, author = {{Vassiliou L.-V.} and {Kim E.E.-Y.} and {Williams L.} and {Bentley R.P.}}, year = {2016}, keywords = {*cerebral artery disease, *consensus development, *cranioplasty, Child, adolescent, adult, aged, brain hemorrhage, cancer epidemiology, clinical trial, comorbidity, controlled clinical trial, controlled study, decompressive craniectomy, female, hospitalization, human, infection, intensive care, major clinical study, male, multicenter study, randomized controlled trial, retrospective study, surgery, survivor, tertiary care center, traumatic brain injury} }
@article{ title = {Vaccines for the prevention of seasonal influenza in patients with diabetes: systematic review and meta-analysis}, type = {article}, year = {2015}, identifiers = {[object Object]}, pages = {53}, volume = {13}, websites = {http://www.biomedcentral.com/1741-7015/13/53}, id = {2cc07ac9-3895-3d7d-840a-282f79e47294}, created = {2015-09-09T15:56:50.000Z}, file_attached = {true}, profile_id = {7a0fec24-6ec6-312f-956e-f210abd2cdb7}, group_id = {943817ab-6073-3383-a1c5-963a6e7efbea}, last_modified = {2015-09-14T17:18:41.000Z}, tags = {VDECGA,VDECICIDFLUREV,VDECL4,VDECVI}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {VDECICIDFLUREV; VDECSG; GA}, bibtype = {article}, author = {Remschmidt, Cornelius and Wichmann, Ole and Harder, Thomas}, journal = {BMC Medicine}, number = {1} }
@book{ title = {Redox ‑ and non ‑ redox ‑ metal ‑ induced formation of free radicals and their role in human disease}, type = {book}, year = {2015}, identifiers = {[object Object]}, keywords = {disease,human,metals,oxidative stress,reactive oxygen species,toxicity}, id = {fff866b0-4ed8-3a96-a2ca-265b853809ec}, created = {2016-08-10T10:10:09.000Z}, file_attached = {true}, profile_id = {5d250c3e-485a-3099-8087-b35242bd2203}, group_id = {a9625e9e-5a77-317b-ab12-c1d6dcc9ef27}, last_modified = {2016-08-10T10:10:35.000Z}, read = {true}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Toxicol2015}, bibtype = {book}, author = {Toxicol, Arch and Valko, Marian and Jomova, Klaudia and Rhodes, Christopher J and Kuc, Kamil} }
@misc{plambech_m.z._dexmedetomidine_2015, title = {Dexmedetomidine in the pediatric population: {A} review}, url = {http://www.minervamedica.it/en/getpdf/sbNvoPlJhvv6bbyfsqY76tEZcB64PRPRZhQ7XFLHe60Q6OIPvcRxmU6QbTTdsDC59xcyai%252BPQuY95g446wPjIA%253D%253D/R02Y2015N03A0320.pdf}, abstract = {Dexmedetomidine, an alpha-2 agonist approved only for sedation in adult intensive care patients, is increasingly used off-label in- and outside Europe in the pediatric setting for various indications such as to prevent agitation, as premedication in the form of intranasal, buccal and oral solution, as adjunct for elective surgery, as sedative for magnetic resonance imaging, as intraoperative analgesia, for extracorporeal shock wave lithotripsy, and as adjuvant to ropi- and bupivacaine for nerve blocks. Dexmedetomidine is also used intravenously at different intensive care units with the purpose of sedation of children. In this paper, we assess 51 minor trials in the form of 44 randomized controlled trials and 7 prospective observational studies in an attempt to update the available evidence on dexmedetomidine use in pediatrics. Furthermore, we discuss its potential indications, benefits and adverse effects. However, it is important to state that much of the existing evidence favoring dexmedetomidine in children is either extrapolated from adult studies or based on small randomized controlled trials and observational studies with their inherent methodological shortcomings and confounding factors. Based on the best current evidence dexmedetomidine is found suitable and safe for various indications. However, in order to discover its full potential, indications, dosing and safety profile for various ages and procedures, it should urgently be examined by conducting good quality pediatric trials. Finally, we provide the readers with guidance on how to apply and dose dexmedetomidine for pediatric sedation and for other indications. Copyright COPYRIGHT © 2015 EDIZIONI MINERVA MEDICA.}, journal = {Minerva Anestesiologica}, author = {{Plambech M.Z.} and {Afshari A.}}, year = {2015}, keywords = {*anesthesia, *child, *deep sedation, *dexmedetomidine, *dexmedetomidine/ae [Adverse Drug Reaction], *dexmedetomidine/ct [Clinical Trial], *dexmedetomidine/na [Intranasal Drug Administration], *human, *pediatrics, *population, Child, Europe, adjuvant, adolescent, adult, adverse drug reaction, agitation, agonist, analgesia, article, bupivacaine, cardiovascular effect, clinical protocol, elective surgery, extracorporeal lithotripsy, human, infant, intensive care, intensive care unit, intranasal drug administration, intraoperative analgesia, intraoperative period, meta analysis (topic), nerve block, newborn, nuclear magnetic resonance imaging, observational study, patient, pediatrics, perioperative period, phase 1 clinical trial (topic), premedication, procedures, randomized controlled trial (topic), reading, safety, sedation, sedative agent, side effect/si [Side Effect], systematic review (topic)} }
@article{ title = {Right parietal cortex mediates recognition memory for melodies}, type = {article}, year = {2015}, identifiers = {[object Object]}, keywords = {human,memory for melodies,posterior parietal cortex,recognition,recollection,transcranial direct current}, websites = {http://doi.wiley.com/10.1111/ejn.12943}, id = {2d8a36c7-0e16-3011-ac6d-0a0f67b29e0f}, created = {2015-06-28T11:13:35.000Z}, file_attached = {true}, profile_id = {69574ccf-a202-3c13-b9e9-b6e77dadc9f9}, last_modified = {2015-06-28T11:13:52.000Z}, read = {false}, starred = {false}, authored = {true}, confirmed = {true}, hidden = {false}, bibtype = {article}, author = {Schaal, Nora K. and Javadi, Amir-Homayoun and Halpern, Andrea R. and Pollok, Bettina and Banissy, Michael J}, journal = {European Journal of Neuroscience} }
@article{gianella_vaginal_2015, title = {Vaginal {Cytomegalovirus} {Shedding} {Before} and {After} {Initiation} of {Antiretroviral} {Therapy} in {Rakai}, {Uganda}}, volume = {212}, issn = {1537-6613}, doi = {10.1093/infdis/jiv135}, abstract = {Vaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0\%) and 379 of 1080 individual visits (35.1\%). ART status, higher HIV RNA viral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P {\textless} .01). Compared to pre-ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.}, language = {eng}, number = {6}, journal = {The Journal of Infectious Diseases}, author = {Gianella, Sara and Redd, Andrew D. and Grabowski, Mary K. and Tobian, Aaron A. R. and Serwadda, David and Newell, Kevin and Patel, Eshan U. and Kalibbala, Sarah and Ssebbowa, Paschal and Gray, Ronald H. and Quinn, Thomas C. and Reynolds, Steven J.}, month = sep, year = {2015}, pmid = {25743428}, pmcid = {PMC4548459}, keywords = {Acyclovir, Adult, Anti-Retroviral Agents, CD4 Lymphocyte Count, Coinfection, Cytomegalovirus, Cytomegalovirus Infections, Double-Blind Method, Female, HIV Infections, Herpes Genitalis, Herpesvirus 2, Human, Humans, Longitudinal Studies, Uganda, Vagina, Virus Shedding, acyclovir, antiretroviral therapy (ART), cytomegalovirus (CMV), human immunodeficiency virus (HIV), immune reconstitution inflammatory syndrome (IRIS), reactivation}, pages = {899--903}, }
@article{ kidd_influenza_2014, title = {Influenza viruses: update on epidemiology, clinical features, treatment and vaccination}, volume = {20}, issn = {1531-6971}, shorttitle = {Influenza viruses}, doi = {10.1097/MCP.0000000000000049}, abstract = {PURPOSE OF REVIEW: In the last decade, sporadic and lethal human disease caused by zoonotic avian influenza viruses, and the seasonal activity of human H1N1 2009 pandemic type have driven intense epidemiological and laboratory studies into the virus life cycle. This article highlights major developments from mid-2012 to early 2014. RECENT FINDINGS: Advances in molecular techniques and efficient rollout of diagnostic tests have enabled the rapid identification of clinical cases and detailed genetic sequencing of viral genomes. Studies have contributed widely to the understanding of how and when influenza viruses circulate, what determines their innate pathogenicity in particular hosts and whether host cofactors influence disease severity. Other imperatives include investigations into how influenza can be better prevented by vaccination, or treated with antiviral drugs. SUMMARY: Avian influenza viruses present a continuous threat to human populations. There is a need for sustained surveillance and downstream research to evaluate the potential for future pandemics.}, language = {eng}, number = {3}, journal = {Current Opinion in Pulmonary Medicine}, author = {Kidd, Mike}, month = {May}, year = {2014}, pmid = {24637227}, keywords = {Animals, Antiviral Agents, DNA, Viral, Drug Resistance, Viral, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H7N9 Subtype, Influenza A virus, Influenza in Birds, Influenza, Human, Male, Pandemics, Poultry, Seasons, Sentinel Surveillance, Sequence Analysis, DNA, Viral Vaccines, Zanamivir}, pages = {242--246} }
@article{ vellozzi_guillain-barre_2014, title = {Guillain-{Barre} syndrome, influenza, and influenza vaccination: the epidemiologic evidence}, volume = {58}, issn = {1537-6591}, shorttitle = {Guillain-{Barre} syndrome, influenza, and influenza vaccination}, doi = {10.1093/cid/ciu005}, abstract = {Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis worldwide, and is thought to be immune-mediated. It is preceded by upper respiratory or gastrointestinal infection in about two-thirds of cases and is associated with some viral infections, including influenza. GBS has also been associated with the 1976 swine-influenza vaccine. Thereafter, some studies have shown a small increased risk of GBS following receipt of seasonal and 2009 H1N1 monovalent influenza vaccines. Studies over the years have also shown an increased risk of GBS following influenza infection, and the magnitude of risk is several times greater than that following influenza vaccination. Because GBS is rare, and even rarer following vaccination, it is difficult to estimate precise risk. We try to shed light on the complex relationship of GBS and its association with influenza and influenza vaccines over the past 35 years.}, language = {eng}, number = {8}, journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America}, author = {Vellozzi, Claudia and Iqbal, Shahed and Broder, Karen}, month = {April}, year = {2014}, pmid = {24415636}, keywords = {Guillain-Barre Syndrome, Humans, Incidence, Influenza Vaccines, Influenza, Human, Vaccination}, pages = {1149--1155} }
@article{ thomas_is_2014, title = {Is influenza-like illness a useful concept and an appropriate test of influenza vaccine effectiveness?}, volume = {32}, issn = {1873-2518}, doi = {10.1016/j.vaccine.2014.02.059}, abstract = {PURPOSE: To assess the utility of "influenza-like illness" (ILI) and whether it appropriately tests influenza vaccine effectiveness. PRINCIPAL RESULTS: The WHO and CDC definitions of "influenza-like illness" are similar. However many studies use other definitions, some not specifying a temperature and requiring specific respiratory and/or systemic symptoms, making many samples non-comparable. Most ILI studies find less than 25% of cases are RT-PCR-positive, those which test for other viruses and bacteria usually find multiple other pathogens, and most identify no pathogen in about 50% of cases. ILI symptom and symptom combinations do not have high sensitivity or specificity in identifying PCR-positive influenza cases. Rapid influenza diagnostic tests are increasingly used to screen ILI cases and they have low sensitivity and high specificity when compared to RT-PCR in identifying influenza. MAIN CONCLUSIONS: The working diagnosis of ILI presumes influenza may be involved until proven otherwise. Health care workers would benefit by renaming the WHO and CDC ILI symptoms and signs as "acute respiratory illness" and also using the WHO acute severe respiratory illness definition if the illness is severe and meets this criterion. This renaming would shift attention to identify the viral and bacterial pathogens in cases and epidemics, identify new pathogens, implement vaccination plans appropriate to the identified pathogens, and estimate workload during the viral season. Randomised controlled trials testing the effectiveness of influenza vaccine require all participants to be assessed by a gold standard (RT-PCR). ILI has no role in measuring influenza vaccine effectiveness. ILI is well established in the literature and in the operational definition of many surveillance databases and its imprecise definition may be inhibiting progress in research and treatment. The current ILI definition could with benefit be renamed "acute respiratory illness," with additional definitions for "severe acute respiratory illness" (SARI) with RT-PCR testing for pathogens to facilitate prevention and treatment.}, language = {eng}, number = {19}, journal = {Vaccine}, author = {Thomas, Roger E.}, month = {April}, year = {2014}, pmid = {24582634}, keywords = {Centers for Disease Control and Prevention (U.S.), Global Health, Humans, Influenza Vaccines, Influenza, Human, Respiratory Tract Diseases, United States, Vaccination}, pages = {2143--2149} }
@article{ title = {Eye-hand coordination in on-line visuomotor adjustments}, type = {article}, year = {2014}, identifiers = {[object Object]}, keywords = {Automatic pilot,Eye-hand coordination,Human,On-line motor control,Reaching,Saccades}, pages = {441-445}, volume = {25}, id = {e0f30b19-5716-3785-a1ba-b6a930209236}, created = {2018-11-22T20:16:45.910Z}, file_attached = {true}, profile_id = {320a2cca-e89a-3024-8447-b202ac8efe57}, group_id = {1378139f-e3de-3b78-a9d2-5c85c2da309f}, last_modified = {2018-11-22T20:17:17.774Z}, tags = {Author=A,Type=small}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Abekawa2014}, private_publication = {false}, abstract = {When we perform a visually guided reaching action, the brain coordinates our hand and eye movements. Eye-hand coordination has been examined widely, but it remains unclear whether the hand and eye motor systems are coordinated during on-line visuomotor adjustments induced by a target jump during a reaching movement. As such quick motor responses are required when we interact with dynamic environments, eye and hand movements could be coordinated even during on-line motor control. Here, we examine the relationship between online hand adjustment and saccadic eye movement. In contrast to the well-known temporal order of eye and hand initiations where the hand follows the eyes, we found that on-line hand adjustment was initiated before the saccade onset. Despite this order reversal, a correlation between hand and saccade latencies was observed, suggesting that the hand motor system is not independent of eye control even when the hand response was induced before the saccade. Moreover, the latency of the hand adjustment with saccadic eye movement was significantly shorter than that with eye fixation. This hand latency modulation cannot be ascribed to any changes of visual or oculomotor reafferent information as the saccade was not yet initiated when the hand adjustment started. Taken together, the hand motor system would receive preparation signals rather than reafference signals of saccadic eye movements to provide quick manual adjustments of the goal-directed eye-hand movements.}, bibtype = {article}, author = {Abekawa, Naotoshi and Inui, Toshio and Gomi, Hiroaki}, journal = {NeuroReport}, number = {7} }
@article{ hebsur_influenza_2014, title = {Influenza and coronary artery disease: exploring a clinical association with myocardial infarction and analyzing the utility of vaccination in prevention of myocardial infarction}, volume = {15}, issn = {1530-6550}, shorttitle = {Influenza and coronary artery disease}, abstract = {Both coronary artery disease and influenza outbreaks contribute significantly to worldwide morbidity and mortality. An increasing number of epidemiologic studies have concluded that a temporal association exists between acute viral illnesses and myocardial infarction. Viral illnesses such as influenza can cause or exacerbate coronary atherosclerosis by activating inflammatory pathways. Data from a large case-controlled trial and two randomized controlled trials suggest that influenza vaccination in patients with coronary artery disease may lead to a decrease in incidence, morbidity, and mortality from acute myocardial infarction. A meta-analysis of the two randomized controlled trials for cardiovascular death demonstrated a pooled relative risk of 0.39 (95% confidence interval, 0.20-0.77) for patients who received the influenza vaccine compared with placebo.}, language = {eng}, number = {2}, journal = {Reviews in Cardiovascular Medicine}, author = {Hebsur, Shrinivas and Vakil, Erik and Oetgen, William J. and Kumar, Princy N. and Lazarous, Daisy F.}, year = {2014}, pmid = {25051134}, keywords = {Humans, Inflammation, Influenza Vaccines, Influenza, Human, Myocardial Infarction, Prognosis, Risk Factors, Vaccination}, pages = {168--175} }
@article{ greenhawt_influenza_2014, title = {Influenza vaccination in asthmatic patients}, volume = {133}, issn = {1097-6825}, doi = {10.1016/j.jaci.2014.02.009}, language = {eng}, number = {4}, journal = {The Journal of Allergy and Clinical Immunology}, author = {Greenhawt, Matthew J.}, month = {April}, year = {2014}, pmid = {24679474}, keywords = {Adult, Asthma, Female, Humans, Influenza Vaccines, Influenza, Human, Vaccination}, pages = {1233--1234} }
@article{ jit_key_2013, title = {Key issues for estimating the impact and cost-effectiveness of seasonal influenza vaccination strategies}, volume = {9}, issn = {2164-554X}, doi = {10.4161/hv.23637}, abstract = {Many countries have considered or are considering modifying their seasonal influenza immunization policies. Estimating the impact of such changes requires understanding the existing clinical and economic burden of influenza, as well as the potential impact of different vaccination options. Previous studies suggest that vaccinating clinical risk groups, health care workers, children and the elderly may be cost-effective. However, challenges in such estimation include: (1) potential cases are not usually virologically tested; (2) cases have non-specific symptoms and are rarely reported to surveillance systems; (3) endpoints for influenza proxies (such as influenza-like illness) need to be matched to case definitions for treatment costs, (4) disease burden estimates vary from year to year with strain transmissibility, virulence and prior immunity, (5) methods to estimate productivity losses due to influenza vary, (6) vaccine efficacy estimates from trials differ due to variation in subtype prevalence, vaccine match and case ascertainment, and (7) indirect (herd) protection from vaccination depends on setting-specific variables that are difficult to directly measure. Given the importance of knowing the impact of changes to influenza policy, such complexities need careful treatment using tools such as population-based trial designs, meta-analyses, time-series analyses and transmission dynamic models.}, language = {eng}, number = {4}, journal = {Human Vaccines \& Immunotherapeutics}, author = {Jit, Mark and Newall, Anthony T. and Beutels, Philippe}, month = {April}, year = {2013}, pmid = {23357859}, pmcid = {PMC3903903}, keywords = {Cost-Benefit Analysis, Humans, Influenza Vaccines, Influenza, Human, Vaccination}, pages = {834--840} }
@article{ subbarao_prospects_2013, title = {The prospects and challenges of universal vaccines for influenza}, volume = {21}, issn = {1878-4380}, doi = {10.1016/j.tim.2013.04.003}, abstract = {Vaccination is the most effective way to reduce the impact of epidemic as well as pandemic influenza. However, the licensed inactivated influenza vaccine induces strain-specific immunity and must be updated annually. When novel viruses appear, matched vaccines are not likely to be available in time for the first wave of a pandemic. Yet, the enormous diversity of influenza A viruses in nature makes it impossible to predict which subtype or strain will cause the next pandemic. Several recent scientific advances have generated renewed enthusiasm and hope for universal vaccines that will induce broad protection from a range of influenza viruses.}, language = {eng}, number = {7}, journal = {Trends in Microbiology}, author = {Subbarao, Kanta and Matsuoka, Yumiko}, month = {July}, year = {2013}, pmid = {23685068}, pmcid = {PMC3700639}, keywords = {Cross Protection, Drug Discovery, Humans, Influenza Vaccines, Influenza, Human}, pages = {350--358} }
@article{ schmidt_quality_2013, title = {Do the quality of the trials and the year of publication affect the efficacy of intervention to improve seasonal influenza vaccination among healthcare workers?: {Results} of a systematic review}, volume = {9}, issn = {2164-554X}, shorttitle = {Do the quality of the trials and the year of publication affect the efficacy of intervention to improve seasonal influenza vaccination among healthcare workers?}, abstract = {INTRODUCTION: Despite longstanding recommendations by public-health authorities vaccination coverage in health care workers worldwide are poor. The aim of this study is to conduct a systematic review of the trials conducted to increase seasonal influenza vaccination rates among health care workers. RESULTS: Ten articles met the pre-determined criteria. For all article the score calculation was performed. DISCUSSION: The combination of an educational and a promotional element appared the most effective in augmenting the influenza vaccination coverage among health care workers. But some cases, the intervention did not contribute to increasing the vaccination rates among health care workers. In any case, the quality of controlled trials plays an important role in the results obtained by carrying out a specific intervention and contributed to obtaining this debatable results. MATERIALS AND METHODS: Research was conducted using Scopus and PubMed database. We selected all clinical trials to perform the meta-analyses.}, language = {eng}, number = {2}, journal = {Human Vaccines \& Immunotherapeutics}, author = {Schmidt, Silvia and Saulle, Rosella and Di Thiene, Domitilla and Boccia, Antonio and La Torre, Giuseppe}, month = {February}, year = {2013}, pmid = {23291943}, pmcid = {PMC3859758}, keywords = {Behavior Therapy, Education, Medical, Guideline Adherence, Health Personnel, Health Promotion, Humans, Influenza Vaccines, Influenza, Human, Vaccination}, pages = {349--361} }
@article{ title = {Reference-free population genomics from next-generation transcriptome data and the vertebrate-invertebrate gap.}, type = {article}, year = {2013}, identifiers = {[object Object]}, keywords = {Animals,Base Sequence,Drosophila,Drosophila: genetics,Genome,Genotype,Hares,Hares: genetics,High-Throughput Nucleotide Sequencing,Human,Humans,Invertebrates,Invertebrates: genetics,Isoptera,Isoptera: genetics,Metagenomics,Ostreidae,Ostreidae: genetics,Polymorphism,Single Nucleotide,Transcriptome,Transcriptome: genetics,Turtles,Turtles: genetics,Urochordata,Urochordata: genetics,Vertebrates,Vertebrates: genetics}, pages = {e1003457}, volume = {9}, websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3623758&tool=pmcentrez&rendertype=abstract}, month = {4}, id = {3639b6ed-7592-301f-8fc7-56d3d09c7c76}, created = {2017-09-18T09:15:16.356Z}, accessed = {2013-08-21}, file_attached = {true}, profile_id = {1c95d708-d42d-399e-b365-9d34fead1a19}, last_modified = {2017-09-18T09:21:29.525Z}, read = {true}, starred = {false}, authored = {true}, confirmed = {true}, hidden = {false}, citation_key = {Gayral2013}, source_type = {article}, notes = { <m:bold>From Duplicate 2 ( </m:bold> <m:bold> <m:italic>Reference-free population genomics from next-generation transcriptome data and the vertebrate-invertebrate gap.</m:italic> </m:bold> <m:bold> - Gayral, Philippe; Melo-Ferreira, José; Glémin, Sylvain; Bierne, Nicolas; Carneiro, Miguel; Nabholz, Benoit; Lourenco, Joao M; Alves, Paulo C; Ballenghien, Marion; Faivre, Nicolas; Belkhir, Khalid; Cahais, Vincent; Loire, Etienne; Bernard, Aurélien; Galtier, Nicolas )<m:linebreak></m:linebreak> </m:bold> <m:linebreak></m:linebreak> <m:linebreak></m:linebreak> <m:linebreak></m:linebreak> }, abstract = {In animals, the population genomic literature is dominated by two taxa, namely mammals and drosophilids, in which fully sequenced, well-annotated genomes have been available for years. Data from other metazoan phyla are scarce, probably because the vast majority of living species still lack a closely related reference genome. Here we achieve de novo, reference-free population genomic analysis from wild samples in five non-model animal species, based on next-generation sequencing transcriptome data. We introduce a pipe-line for cDNA assembly, read mapping, SNP/genotype calling, and data cleaning, with specific focus on the issue of hidden paralogy detection. In two species for which a reference genome is available, similar results were obtained whether the reference was used or not, demonstrating the robustness of our de novo inferences. The population genomic profile of a hare, a turtle, an oyster, a tunicate, and a termite were found to be intermediate between those of human and Drosophila, indicating that the discordant genomic diversity patterns that have been reported between these two species do not reflect a generalized vertebrate versus invertebrate gap. The genomic average diversity was generally higher in invertebrates than in vertebrates (with the notable exception of termite), in agreement with the notion that population size tends to be larger in the former than in the latter. The non-synonymous to synonymous ratio, however, did not differ significantly between vertebrates and invertebrates, even though it was negatively correlated with genetic diversity within each of the two groups. This study opens promising perspective regarding genome-wide population analyses of non-model organisms and the influence of population size on non-synonymous versus synonymous diversity.}, bibtype = {article}, author = {Gayral, Philippe and Melo-Ferreira, José and Glémin, Sylvain and Bierne, Nicolas and Carneiro, Miguel and Nabholz, Benoit and Lourenco, Joao M and Alves, Paulo C and Ballenghien, Marion and Faivre, Nicolas and Belkhir, Khalid and Cahais, Vincent and Loire, Etienne and Bernard, Aurélien and Galtier, Nicolas}, journal = {PLoS genetics}, number = {4} }
@misc{carlo_w.a._neurodevelopmental_2012, title = {Neurodevelopmental outcomes in infants requiring resuscitation in developing countries}, abstract = {OBJECTIVE: To determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment., STUDY DESIGN: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported., RESULTS: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index {\textless}85 on the Bayley Scales of Infant Development-II (primary outcome; 18\% versus 12\%; P = .22) and in other neurodevelopmental outcomes., CONCLUSIONS: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments. Copyright © 2012 Mosby, Inc. All rights reserved.}, journal = {The Journal of pediatrics}, author = {{Carlo W.A.} and {Goudar S.S.} and {Pasha O.} and {Chomba E.} and {McClure E.M.} and {Biasini F.J.} and {Wallander J.L.} and {Thorsten V.} and {Chakraborty H.} and {Wright L.L.}}, year = {2012}, keywords = {*adverse effects, *procedures, Developmental Disabilities/di [Diagnosis], Developmental Disabilities/ep [Epidemiology], India, Learning Disorders/di [Diagnosis], Learning Disorders/ep [Epidemiology], Mental Disorders/di [Diagnosis], Mental Disorders/ep [Epidemiology], Pakistan, Respiratory Distress Syndrome, Newborn/th [Therapy], Zambia, child development, clinical trial, comparative study, controlled study, developing country, female, human, incidence, infant, male, multicenter study, neuropsychological test, newborn, physiology, prematurity, randomized controlled trial, reference value, resuscitation, risk assessment, rural population, severity of illness index, survival analysis, very low birth weight} }
@article{ title = {Human evolutionary genomics: ethical and interpretive issues.}, type = {article}, year = {2012}, identifiers = {[object Object]}, keywords = {Animals,Bioethics,Evolution, Molecular,Genome, Human,Genomics,Humans,Selection, Genetic}, pages = {137-45}, volume = {28}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/22265990}, month = {3}, publisher = {Elsevier Ltd}, id = {89ec61e9-bb0e-313a-9fc8-3981b070543d}, created = {2017-06-19T13:41:03.874Z}, accessed = {2012-11-06}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:41:04.018Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {Genome-wide computational studies can now identify targets of natural selection. The unique information about humans these studies reveal, and the media attention they attract, indicate the need for caution and precision in communicating results. This need is exacerbated by ways in which evolutionary and genetic considerations have been misapplied to support discriminatory policies, by persistent misconceptions of these fields and by the social sensitivity surrounding discussions of racial ancestry. We discuss the foundations, accomplishments and future directions of human evolutionary genomics, attending to ways in which the interpretation of good science can go awry, and offer suggestions for researchers to prevent misapplication of their work.}, bibtype = {article}, author = {Vitti, Joseph J and Cho, Mildred K and Tishkoff, Sarah a and Sabeti, Pardis C}, journal = {Trends in genetics : TIG}, number = {3} }
@article{ title = {Efficacy and effectiveness of influenza vaccines: A systematic review and meta-analysis}, type = {article}, year = {2012}, identifiers = {[object Object]}, keywords = {Vaccine effectiveness}, pages = {36-44}, volume = {12}, id = {0f707827-12dc-3fde-a01c-bef2cbdbbf77}, created = {2015-09-09T15:56:50.000Z}, file_attached = {true}, profile_id = {7a0fec24-6ec6-312f-956e-f210abd2cdb7}, group_id = {943817ab-6073-3383-a1c5-963a6e7efbea}, last_modified = {2015-09-14T21:03:56.000Z}, tags = {VDECGA,VDECICIDFLUREV,VDECVE}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {Background: No published meta-analyses have assessed efficacy and effectiveness of licensed influenza vaccines in the USA with sensitive and highly specific diagnostic tests to confirm influenza. Methods: We searched Medline for randomised controlled trials assessing a relative reduction in influenza risk of all circulating influenza viruses during individual seasons after vaccination (efficacy) and observational studies meeting inclusion criteria (effectiveness). Eligible articles were published between Jan 1, 1967, and Feb 15, 2011, and used RT-PCR or culture for confirmation of influenza. We excluded some studies on the basis of study design and vaccine characteristics. We estimated random-effects pooled efficacy for trivalent inactivated vaccine (TIV) and live attenuated influenza vaccine (LAIV) when data were available for statistical analysis (eg, at least three studies that assessed comparable age groups). Findings: We screened 5707 articles and identified 31 eligible studies (17 randomised controlled trials and 14 observational studies). Efficacy of TIV was shown in eight (67%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 59% [95% CI 51-67] in adults aged 18-65 years). No such trials met inclusion criteria for children aged 2-17 years or adults aged 65 years or older. Efficacy of LAIV was shown in nine (75%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 83% [69-91]) in children aged 6 months to 7 years. No such trials met inclusion criteria for children aged 8-17 years. Vaccine effectiveness was variable for seasonal influenza: six (35%) of 17 analyses in nine studies showed significant protection against medically attended influenza in the outpatient or inpatient setting. Median monovalent pandemic H1N1 vaccine effectiveness in five observational studies was 69% (range 60-93). Interpretation: Influenza vaccines can provide moderate protection against virologically confirmed influenza, but such protection is greatly reduced or absent in some seasons. Evidence for protection in adults aged 65 years or older is lacking. LAIVs consistently show highest efficacy in young children (aged 6 months to 7 years). New vaccines with improved clinical efficacy and effectiveness are needed to further reduce influenza-related morbidity and mortality. Funding: Alfred P Sloan Foundation. © 2012 Elsevier Ltd.}, bibtype = {article}, author = {Osterholm, Michael T. and Kelley, Nicholas S. and Sommer, Alfred and Belongia, Edward a.}, journal = {The Lancet Infectious Diseases}, number = {1} }
@inProceedings{ id = {a6b630ec-5c73-3f94-95b6-8a2d0b39d6a3}, title = {Do Different Hint Techniques Embedded in a Digital Game-Based Learning Tool have an effect on students ’ behavior ?}, type = {inProceedings}, year = {2011}, keywords = {computer interaction,digital game based learning,education,human,learn to play and,mental thinking,periodic table of,play to learn}, created = {2013-03-26T11:06:32.000Z}, file_attached = {true}, profile_id = {e7747f90-d244-30f0-8ab8-040e1ce7fcca}, group_id = {eb547711-a9bc-34f4-87c4-f439162c9d1c}, last_modified = {2014-10-22T17:07:45.000Z}, read = {true}, starred = {false}, authored = {false}, confirmed = {false}, hidden = {false}, bibtype = {inProceedings}, author = {Hjert-bernardi, Kiira and Hernández-leo, Davinia and Melero, Javier and Blat, Josep}, booktitle = {Workshop Ambient Games on International Joint Conference on Ambient Intelligence} }
@article{ mcelhaney_influenza_2011, title = {Influenza vaccine responses in older adults}, volume = {10}, issn = {1872-9649}, doi = {10.1016/j.arr.2010.10.008}, abstract = {The most profound consequences of immune senescence with respect to public health are the increased susceptibility to influenza and loss of efficacy of the current split-virus influenza vaccines in older adults, which are otherwise very effective in younger populations. Influenza infection is associated with high rates of complicated illness including pneumonia, heart attacks and strokes in the 65+ population. Changes in both innate and adaptive immune function not only converge in the reduced response to vaccination and protection against influenza, but present significant challenges to new vaccine development. In older adults, the goal of vaccination is more realistically targeted to providing clinical protection against disease rather sterilizing immunity. Correlates of clinical protection may not be measured using standard techniques such as antibody titres to predict vaccine efficacy. Further, antibody responses to vaccination as a correlate of protection may fail to detect important changes in cellular immunity and enhanced vaccine-mediated protection against influenza illness in older people. This article will discuss the impact of influenza in older adults, immunologic targets for improved efficacy of the vaccines, and alternative correlates of clinical protection against influenza that are needed for more effective translation of novel vaccination strategies to improved protection against influenza in older adults.}, language = {eng}, number = {3}, journal = {Ageing Research Reviews}, author = {McElhaney, Janet E.}, month = {July}, year = {2011}, pmid = {21055484}, pmcid = {PMC3061971}, keywords = {Adaptive Immunity, Aged, Aged, 80 and over, Aging, Humans, Immunity, Innate, Influenza Vaccines, Influenza, Human, T-Lymphocytes, Treatment Outcome}, pages = {379--388} }
@article{birrell_bayesian_2011, title = {Bayesian modeling to unmask and predict influenza {A}/{H}1N1pdm dynamics in {London}}, volume = {108}, issn = {1091-6490}, doi = {10.1073/pnas.1103002108}, abstract = {The tracking and projection of emerging epidemics is hindered by the disconnect between apparent epidemic dynamics, discernible from noisy and incomplete surveillance data, and the underlying, imperfectly observed, system. Behavior changes compound this, altering both true dynamics and reporting patterns, particularly for diseases with nonspecific symptoms, such as influenza. We disentangle these effects to unravel the hidden dynamics of the 2009 influenza A/H1N1pdm pandemic in London, where surveillance suggests an unusual dominant peak in the summer. We embed an age-structured model into a bayesian synthesis of multiple evidence sources to reveal substantial changes in contact patterns and health-seeking behavior throughout the epidemic, uncovering two similar infection waves, despite large differences in the reported levels of disease. We show how this approach, which allows for real-time learning about model parameters as the epidemic progresses, is also able to provide a sequence of nested projections that are capable of accurately reflecting the epidemic evolution.}, language = {eng}, number = {45}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, author = {Birrell, Paul J. and Ketsetzis, Georgios and Gay, Nigel J. and Cooper, Ben S. and Presanis, Anne M. and Harris, Ross J. and Charlett, André and Zhang, Xu-Sheng and White, Peter J. and Pebody, Richard G. and De Angelis, Daniela}, month = nov, year = {2011}, pmid = {22042838}, pmcid = {PMC3215054}, keywords = {Bayes Theorem, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, London}, pages = {18238--18243} }
@article{pentland_key_2011, title = {Key characteristics of knowledge transfer and exchange in healthcare: integrative literature review}, volume = {67}, issn = {1365-2648}, shorttitle = {Key characteristics of knowledge transfer and exchange in healthcare}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2648.2011.05631.x}, doi = {10/bbmtr4}, language = {en}, number = {7}, urldate = {2019-01-13}, journal = {Journal of Advanced Nursing}, author = {Pentland, Duncan and Forsyth, Kirsty and Maciver, Donald and Walsh, Mike and Murray, Richard and Irvine, Linda and Sikora, Simon}, year = {2011}, keywords = {\#à lire 📖}, pages = {1408--1425} }
@article{ title = {Optimizing clinical environments for knowledge translation: strategies for nursing leaders.}, type = {article}, year = {2011}, identifiers = {[object Object]}, keywords = {Evidence-Based Nursing,Humans,Models, Nursing,Models, Organizational,Nurse Administrators,Nursing, Supervisory,Organizational Culture,Patient Care Team,evidence based nursing,human,leadership,methodology,model,nonbiological model,nurse administrator,nursing,nursing research,organization,organization and management,patient care,psychological aspect,review,social environment,uncertainty}, pages = {73-85}, volume = {24}, websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84857378230&partnerID=40&md5=01153990c31273801d8559dc71b43d25}, city = {Affiliation: Faculty of Nursing, University of Alberta, Edmonton, AB, Canada.; Correspondence Address: Scott, S.D.email: Shannon.scott@ualberta.ca}, id = {dd7d9064-764b-3047-b4c2-a2fbc91d7611}, created = {2016-08-21T22:17:39.000Z}, file_attached = {false}, profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597}, group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4}, last_modified = {2017-03-14T09:54:45.334Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {JOUR}, folder_uuids = {028056a6-dab5-46a4-b9bf-02542e7cfa2b}, private_publication = {false}, abstract = {Using findings from our recent study that found that a context of uncertainty in the work environment hindered nurses' research utilization, we suggest strategies for nurse managers and leaders to optimize clinical environments and support efforts to put research into clinical practice (knowledge translation). Two important sources of uncertainty were the complexity of teamwork and inconsistency in management and leadership styles. To reduce the uncertainty arising from teamwork, we propose (a) clarifying nurses' scopes of practice, (b) increasing knowledge sharing through supporting journal clubs and enhanced computer access and (c) creating safe venues for multidisciplinary dialogue. To reduce uncertainty arising from variations in management and leadership, we propose (a) developing policies that enhance the consistency of leadership and clarify the strategic direction of the management team, (b) clearly communicating those policies to nurses and (c) providing explicit rationales for treatment changes. Small, incremental steps can be taken to realize substantive changes in clinical environments in order to optimize nursing work environments for knowledge translation.}, bibtype = {article}, author = {Scott, S D and VandenBeld, B and Cummings, G G}, journal = {Nursing leadership (Toronto, Ont.)}, number = {3} }
@article{ title = {The human genetic history of Oceania: near and remote views of dispersal.}, type = {article}, year = {2010}, identifiers = {[object Object]}, keywords = {Chromosomes, Human, Y,Chromosomes, Human, Y: genetics,DNA, Mitochondrial,DNA, Mitochondrial: genetics,Demography,Emigration and Immigration,Female,Genetics, Population,Haplotypes,Haplotypes: genetics,History, Ancient,Humans,Linguistics,Male,Oceania,Oceanic Ancestry Group,Oceanic Ancestry Group: genetics,Oceanic Ancestry Group: history}, pages = {R194-201}, volume = {20}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/20178767}, month = {2}, publisher = {Elsevier Ltd}, day = {23}, id = {f76953c5-ce52-39a2-89de-966bf4392257}, created = {2017-06-19T13:46:17.041Z}, accessed = {2012-10-24}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:46:17.274Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {The human history of Oceania is unique in the way that it encompasses both the first out-of-Africa expansion of modern humans to New Guinea and Australia as well as the last regional human occupation of Polynesia. Other anthropological peculiarities of Oceania include features like the extraordinarily rich linguistic diversity especially of New Guinea with about 1,000 often very distinct languages, the independent and early development of agriculture in the highlands of New Guinea about 10,000 years ago, or the long-term isolation of the entire region from the outside world, which lasted as long as until the 1930s for most of the interior of New Guinea. This review will provide an overview on the genetic aspects of human population history of Oceania and how some of the anthropological peculiarities are reflected in human genetic data. Due to current data availability it will mostly focus on insights from sex-specifically inherited mitochondrial DNA and Y-chromosomal DNA, whereas more genome-wide autosomal DNA data are soon expected to add additional details or may correct views obtained from these two, albeit highly complex, genetic loci.}, bibtype = {article}, author = {Kayser, Manfred}, journal = {Current biology : CB}, number = {4} }
@ARTICLE{Adams2008, author = {Adams, Susan M. and Bosch, Elena and Balaresque, Patricia L. and Ballereau, Stéphane J. and Lee, Andrew C. and Arroyo, Eduardo and López-Parra, Ana M. and Aler, Mercedes and Grifo, Marina S. Gisbert and Brion, Maria and Carracedo, Angel and Lavinha, João and Martínez-Jarreta, Begoña and Quintana-Murci, Lluis and Picornell, Antònia and Ramon, Misericordia and Skorecki, Karl and Behar, Doron M. and Calafell, Francesc and Jobling, Mark A.}, title = {The Genetic Legacy of Religious Diversity and Intolerance: Paternal Lineages of Christians, Jews, and Muslims in the Iberian Peninsula}, journal = {The American Journal of Human Genetics}, year = {2008}, volume = {83}, pages = {725--736}, number = {6}, month = dec, file = {:Adamsetal08_humanIB.pdf:PDF}, issn = {0002-9297}, owner = {Tiago}, refid = {S0002-9297(08)00592-2 DOI - 10.1016/j.ajhg.2008.11.007}, subdatabase = {other}, timestamp = {2009.01.16}, url = {http://linkinghub.elsevier.com/retrieve/pii/S0002929708005922} }
@article{ title = {The effects of aging on researchers' publication and citation patterns}, type = {article}, year = {2008}, identifiers = {[object Object]}, keywords = {Authorship,Biomedical Research,Canada,Humans,National Institutes of Health (U.S.),Periodicals as Topic,Publications,Quebec,Research Personnel,United States,Universities,adult,age distribution,aged,aging,article,awards and prizes,career mobility,citation analysis,controlled study,human,job performance,medical research,middle aged,national health organization,personnel,productivity,publication,publishing,retirement,scientific literature,task performance,university,writing}, volume = {3}, websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-58149177148&partnerID=40&md5=ccd9ed40bda091b5b68abbe7fbcd7b9e}, city = {Observatoire des Sciences et des Technologies (OST), Centre Interuniversitaire de Recherche sur la Science et la Technologie (CIRST), Université du Québec à Montréal, Montréal, QC, Canada}, id = {7f2ad728-1627-38a2-9125-4c643ea075b4}, created = {2013-07-15T08:46:13.000Z}, file_attached = {true}, profile_id = {6b9e542c-4cf1-39ce-884a-25bca7f8496c}, group_id = {60cd19b5-2fd5-3898-a22e-e5732aded4d6}, last_modified = {2017-03-14T12:00:36.003Z}, read = {true}, starred = {true}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Gingras2008}, source_type = {JOUR}, notes = {Cited By (since 1996):22<br/><br/><br/>Export Date: 15 July 2013<br/><br/><br/>Source: Scopus<br/><br/><br/>Art. No.: e4048<br/><br/><br/>:doi 10.1371/journal.pone.0004048<br/><br/><br/>PubMed ID: 19112502<br/><br/><br/>Language of Original Document: English<br/><br/><br/>Correspondence Address: Gingras, Y.; Observatoire des Sciences et desTechnologies (OST), Centre Interuniversitaire de Recherche sur la Science et la Technologie (CIRST), Université du Québec à Montréal, Montréal, QC, Canada; email: gingras.yves@uqam.ca<br/><br/><br/>References: Holden, C., The incredible aging investigator (2008) Science, 31, p. 391; <br/>Numbers are, , http://grants.nih.gov/grants/new_investigators/resources.htm, available at: Accessed on March 3, 2008; <br/>Association of Universities and Colleges of Canada (2007) Trends in Higher Education-2: Faculty. Ottawa: Association of Universities and Colleges of Canada. 49 pLehman, H.C., (1953) Age and Achievement, , Princeton: Princeton University Press. 359 p; <br/>Feist, G.J., (2006) The psychology of science and the origins of the scientific mind, , For a good review of the topic, see, New Haven: Yale University Press. 316 p; <br/>Adams, C.W., The age at which scientists do their best work (1946) Isis, 36, pp. 166-169; <br/>Zuckerman, H., Merton, R.K., Age, aging and age structure in science (1973) The Sociology of Science, pp. 493-560. , Merton RK, ed, Chicago: Chicago University Press. pp; <br/>Zuckerman, H., (1977) Scientific elite: Nobel laureates in the United States, , New York: The Free Press. 335 p; <br/>Dietrich, A., Srinivasan, N., The optimal age to start a revolution (2007) J Creative Behav, 41, pp. 339-351; <br/>Shinn, T., Hiérarchie des chercheurs et formes de recherches. (1988) Act Rech Sci Soc, 74, pp. 2-22; <br/>Simonton, D.K., (1994) Greatness: Who makes history and why, , New York: Guilford Press. 502 p; <br/>Stern, S., Age and achievement in mathematics: A Case-Study in the Sociology of Science (1978) Soc Stud Sci, 8, pp. 127-140; <br/>Gieryn, T.F., The aging of a science and its exploitation of innovation: Lessons from X-ray and radio astronomy (1981) Scientometrics, 3, pp. 325-334; <br/>Over, R., Does scholarly impact decline with age? (1988) Scientometrics, 13, pp. 215-223; <br/>Horner, K.L., Rushton, J.P., Vernon, P.A., Relation between aging and research productivity of academic psychologists (1986) Psychology and Aging, 1, pp. 319-324; <br/>Cole, S., Age and Scientific Performance (1979) Am J Soc, 84, pp. 958-977; <br/>Dennis, W., Age and productivity among scientists (1956) Science, 123, pp. 724-725; <br/>Wray, K.B., Is science really a young man's game? (2003) Soc Stud Sci, 33, pp. 137-149; <br/>Wray, K.B., An examination of the contributions of young scientists in new fields (2004) Scientometrics, 61, pp. 117-128; <br/>Kyvik, S., Olsen, T.B., Does the aging of tenured academic staff affect the research performance of universities? (2008) Scientometrics, 76, pp. 439-455; <br/>Allison, P.D., Steward, J.A., Productivity differences among scientists: Evidence for accumulative advantage (1974) Am Soc Rev, 39, pp. 596-606; <br/>Simonton, D.K., Creative productivity and age: A mathematical model based on a two-step cognitive process (1984) Developmental Rev, 4, pp. 77-111; <br/>Simonton, D.K., A predictive and explanatory model of career trajectories and landmarks (1997) Psycho Rev, 104, pp. 251-267; <br/>Kuhn, T.S., (1962) The Structure of Scientific Revolutions, , Chicago: University of Chicago Press. 171 p; <br/>Merton, R.K., (1973) The sociology of science: Theoretical and empirical investivations, , Chicago: University of Chicago Press. 605 p; <br/>Merton, R.K., (1968) Social theory and social structure, , New York: The Free Press. 702 p; <br/>Bourdieu, P., The specificity of the scientific field and the social conditions of the progress of reason (1975) Social Science Information, 14, pp. 19-47; <br/>Le système universitaire québécois: Données et indicateurs (2006) Québec: Bibliothèque et Archives nationales du Québec, , CREPUQ , 120 p; <br/>http://scientific.thomsonreuters.com/products/scie, See:, http://scientific.thomsonreuters.com/products/ssci;http://scientific.thomsonreuters.com/products/ahciGarfield, E., How ISI selects journals for coverage: Quantitative and qualitative consideration (1990) Essays of an Information Scientist, 13, pp. 185-193; <br/>Larivière, V., Archambault, E., Gingras, Y., Vignola-Gagné, E., The place of serials in referencing practices: Comparing natural sciences and engineering with social sciences and humanities (2006) JASIST, 57, pp. 997-1004. , For an analysis of the difference of coverage between sciences and social science see; <br/>Archambault, E., Vignola-Gagné, E., Côté, G., Larivière, V., Gingras, Y., Benchmarking scientific output in the social sciences and humanities: The limits of existing databases (2006) Scientometrics, 68, pp. 329-342; <br/>Moed, H.F., Differences in the construction of SCI based bibliometric indicators among various producers: A first overview (1996) Scientometrics, 35, pp. 177-191; <br/>The SCI only indexes surname and initials of authors, which creates a high number of potential namesakesPrice, D.J.D., (1970) Citation measures of hard science, soft science, technology, and nonscience, pp. 155-179. , Nelson CE, Pollack DK, eds. Communication among scientists and engineers. New York: Columbia University Press. pp; <br/>This might the fact that the age of cited literature has been increasing steadily since the seventies. See: Larivière V, Archambault E, Gingras Y (2008) Long-term variations in the aging of scientific literature: From exponential growth to steady-state science 1900-2004, JASIST 59: 288-296Barnett, G.A., Fink, E.L., Impact of the internet and scholar age distribution on academic citation age (2008) JASIST, 59, pp. 526-534; <br/>It is a well know fact that, in the calculation of their impact factors, Thomson Scientific counts citations received by all document types published (articles reviews, editorials, news items, etc.) but then only divides these citations by the number of articles and reviews published, which are considered as citable items. This has the effect of artificially increasing the impact factor of journals with a higher ratio of non-citable items. For a historical review of impact factors' limits see: Archambault E, Larivière V (2009) History of the journal impact factor: Contingencies and consequences. Scientometrics. 79. In pressMoed, H.F., De Bruin, R.E., van Leeuwen, T.N., New bibliometric tools for the assessment of national research performance: Database description, overview of indicators and first applications (1995) Scientometrics, 33, pp. 381-422; <br/>Schubert, A., Braun, T., Relative indicators and relational charts for comparative assessment of publication output and citation impact (1986) Scientometrics, 9, pp. 281-291; <br/>Sigogneau A (2000) An analysis of document types published in journals related to physics: Proceeding papers recorded in the Science Citation Index database. Scientometrics 47(3): 589-604Biagioli, M., Galison, P., (2003) Scientific authorship: Credit and intellectual property in science, , New York: Routledge. 396 p; <br/>Birnholtz, J., What does it mean to be an author? The intersection of credit, contribution and collaboration in science (2006) JASIST, 57, pp. 1758-1770; <br/>Pontille, D., (2004) La signature scientifique: Une sociologie pragmatique de l'attribution, , Paris: CNRS Éditions. 200 p; <br/>Merton, R.K., The Matthew effect in science (1968) Science, 159, pp. 56-63; <br/>Liang, L., Guo, Y., Davis, M., Collaborative patterns and age structures in Chinese publications (2001) Scientometrics, 54, pp. 473-489; <br/>Kaiser, J., The graying of NIH research (2008) Science, 322, pp. 848-849}, private_publication = {false}, abstract = {The average age at which U.S. researchers receive their first grant from NIH has increased from 34.3 in 1970, to 41.7 in 2004. These data raise the crucial question of the effects of aging on the scientific productivity and impact of researchers. Drawing on a sizeable sample of 6,388 university professors in Quebec who have published at least one paper between 2000 and 2007, our results identify two turning points in the professors' careers. A first turning point is visible at age 40 years, where researchers start to rely on older literature and where their productivity increases at a slower pace - after having increased sharply since the beginning of their career. A second turning point can be seen around age 50, when researchers are the most productive whereas their average scientific impact is at its lowest. Our results also show that older professors publish fewer first-authored papers and move closer to the end of the list of co-authors. Although average scientific impact per paper decreases linearly until about age 50, the average number of papers in highly cited journals and among highly cited papers rises continuously until retirement. Our results show clearly that productivity and impact are not a simple and declining function of age and that we must take into account the collaborative aspects of scientific research. Science is a collective endeavor and, as our data shows, researchers of all ages play a significant role in its dynamic. © 2008 Gingras et al.}, bibtype = {article}, author = {Gingras, Y and Larivière, V and Macaluso, B and Robitaille, J.-P.}, journal = {PLoS ONE}, number = {12} }
@article{ title = {Rapid prototyping of microfluidic devices with a wax printer.}, type = {article}, year = {2007}, identifiers = {[object Object]}, keywords = {Humans,Immunohistochemistry,Mammary Glands, Human,Mammary Glands, Human: cytology,Microfluidics,Microfluidics: instrumentation}, pages = {384-7}, volume = {7}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/17330171}, month = {3}, id = {9b46b840-7d64-3402-8cd7-aa51f24a09a8}, created = {2016-06-24T20:49:45.000Z}, accessed = {2014-05-10}, file_attached = {false}, profile_id = {954a987f-819f-3985-95a4-2991e0cf0552}, group_id = {8440dcff-74cc-3783-aef7-fe2749cfc7ef}, last_modified = {2016-06-24T20:49:45.000Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {Kaigala2007}, abstract = {We demonstrate a rapid and inexpensive approach for the fabrication of high resolution poly(dimethylsiloxane) (PDMS)-based microfluidic devices. The complete process of fabrication could be performed in several hours (or less) without any specialized equipment other than a consumer-grade wax printer. The channels produced by this method are of high enough quality that we are able to demonstrate the sizing and separation of DNA fragments using capillary electrophoresis (CE) with no apparent loss of resolution over that found with glass chips fabricated by conventional photolithographic methods. We believe that this method will greatly improve the accessibility of rapid prototyping methods.}, bibtype = {article}, author = {Kaigala, Govind V and Ho, Sunny and Penterman, Roel and Backhouse, Christopher J}, journal = {Lab on a chip}, number = {3} }
@article{cachay_herpes_2007, title = {Herpes simplex virus type 2 infection does not influence viral dynamics during early {HIV}-1 infection}, volume = {195}, issn = {0022-1899}, doi = {10.1086/513568}, abstract = {OBJECTIVE: We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)-seropositive and -seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California. DESIGN: The study was a retrospective cohort analysis. METHODS: We categorized antiretroviral-naive subjects on the basis of HSV-2 serostatus at baseline using an HSV-2 enzyme immunoassay. Low positive results (1.1-3.5) were confirmed by Western blotting. We compared baseline HIV-1 loads of the 2 groups using a linear model. To detect differences in HIV-1 dynamics, we analyzed longitudinal viral loads using a flexible semiparametric model, controlling for the time to antiretroviral therapy and stratifying by HIV-1 infection stage at entry. RESULTS: We studied 294 adult men. Ninety percent reported sex with men as their main HIV-1 risk factor. The seroprevalence of HSV-2 was 41.5\%. The HSV-2-seropositive and -seronegative groups had similar baseline HIV-1 loads during acute infection (5.52 vs. 5.72 log(10) copies/mL; P=.39) and early infection (4.57 vs. 4.67 log(10) copies/mL; P=.5). Longitudinally, the difference in HIV-1 loads between HSV-2-seropositive and -seronegative men remained close to 0 during the first year of infection. CONCLUSIONS: HSV-2 serostatus has minimal influence on the dynamics of HIV-1 during acute and early HIV-1 infection.}, language = {eng}, number = {9}, journal = {The Journal of Infectious Diseases}, author = {Cachay, Edward R. and Frost, Simon D. W. and Richman, Douglas D. and Smith, Davey M. and Little, Susan J.}, month = may, year = {2007}, pmid = {17396995}, keywords = {Adult, California, Cohort Studies, HIV Infections, HIV-1, Herpes Simplex, Herpesvirus 2, Human, Humans, Longitudinal Studies, Male, Prevalence, Retrospective Studies, Viral Load}, pages = {1270--1277}, }
@article{hippisley-cox_qflu:_2006, title = {{QFLU}: new influenza monitoring in {UK} primary care to support pandemic influenza planning}, volume = {11}, issn = {1560-7917}, shorttitle = {{QFLU}}, language = {eng}, number = {6}, journal = {Euro Surveillance: Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin}, author = {Hippisley-Cox, J. and Smith, S. and Smith, G. and Porter, A. and Heaps, M. and Holland, R. and Fenty, J. and Harcourt, S. and George, R. and Charlett, A. and Pebody, R. G. and Painter, M.}, year = {2006}, pmid = {16819130}, keywords = {Communicable Disease Control, Disease Notification, Disease Outbreaks, Family Practice, Great Britain, Health Planning, Humans, Influenza, Human, Population Surveillance, Primary Health Care, Risk Assessment, Risk Factors, incidence}, pages = {E060622.4} }
@article{ title = {The knowledge-value chain: A conceptual framework for knowledge translation in health}, type = {article}, year = {2006}, identifiers = {[object Object]}, keywords = {Biomedical Research,Humans,Information Dissemination,Information Systems,Public Health Administration,conceptual framework,education policy,evidence based medicine,health care organization,health care policy,health practitioner,health program,health service,human,human relation,knowledge,learning,medical literature,medical practice,medical research,professional knowledge,public health,review,systematic review,world health organization}, pages = {597-602}, volume = {84}, websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33748346673&partnerID=40&md5=07c2c903c1ddffd98d455121833cb07e}, city = {Affiliation: Department of Management, Faculty of Business, Laval University, Québec City, Que. G1K 7P4, Canada; Affiliation: Department of Knowledge Management and Sharing, World Health Organization, 1211 Geneva 27, Switzerland; Affiliation: Canadian Hea}, id = {db3b79d4-cc6a-393c-b38b-1e9fdae127d4}, created = {2016-08-21T22:17:40.000Z}, file_attached = {false}, profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597}, group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4}, last_modified = {2017-03-14T09:54:45.334Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {JOUR}, notes = {Cited By (since 1996): 34}, folder_uuids = {028056a6-dab5-46a4-b9bf-02542e7cfa2b}, private_publication = {false}, abstract = {This article briefly discusses knowledge translation and lists the problems associated with it. Then it uses knowledge-management literature to develop and propose a knowledge-value chain framework in order to provide an integrated conceptual model of knowledge management and application in public health organizations. The knowledge-value chain is a non-linear concept and is based on the management of five dyadic capabilities: mapping and acquisition, creation and destruction, integration and sharing/transfer, replication and protection, and performance and innovation.}, bibtype = {article}, author = {Landry, R and Amara, N and Pablos-Mendes, A and Shademani, R and Gold, I}, journal = {Bulletin of the World Health Organization}, number = {8} }
@article{ title = {Knowledge translation and interprofessional collaboration: Where the rubber of evidence-based care hits the road of teamwork.}, type = {article}, year = {2006}, identifiers = {[object Object]}, keywords = {Canada,Evidence-Based Medicine,Health Knowledge, Attitudes, Practice,Humans,Patient Care Team,attitude to health,evidence based medicine,human,interdisciplinary communication,patient care,review}, pages = {46-54}, volume = {26}, websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-33646840490&partnerID=40&md5=d7aef5f3382da0e0f0962de30d58e307}, city = {Affiliation: Knowledge Translation Centre at St. Michael's Hospital and Department of Health Policy, Management and Evaluation, University of Toronto, Ontario.; Correspondence Address: Zwarenstein, M.}, id = {af161318-8eda-3182-9528-fd94c7c2a8ad}, created = {2016-08-21T22:17:35.000Z}, file_attached = {false}, profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597}, group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4}, last_modified = {2017-03-14T09:54:45.334Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {JOUR}, notes = {Cited By (since 1996): 45}, folder_uuids = {028056a6-dab5-46a4-b9bf-02542e7cfa2b}, private_publication = {false}, abstract = {Knowledge-translation interventions and interprofessional education and collaboration interventions all aim at improving health care processes and outcomes. Knowledge-translation interventions attempt to increase evidence-based practice by a single professional group and thus may fail to take into account barriers from difficulties in interprofessional relations. Interprofessional education and collaboration interventions aim to improve interprofessional relations, which may in turn facilitate the work of knowledge translation and thus evidence-based practice. We summarize systematic review work on the effects of interventions for interprofessional education and collaboration. The current evidence base contains mainly descriptive studies of these interventions. Knowledge is limited regarding the impact on care and outcomes and the extent to which the interventions increase the practice of evidence-based care. Rigorous multimethod research studies are needed to develop and strengthen the current evidence base in this field. We describe a Health Canada-funded randomized trial in which quantitative and qualitative data will be gathered in 20 general internal medicine units located at 5 Toronto, Ontario, teaching hospitals. The project examines the impact of interprofessional education and collaboration interventions on interprofessional relationships, health care processes (including evidence-based practice), and patient outcomes. Routes are suggested by which interprofessional education and collaboration interventions might affect knowledge translation and evidence-based practice.}, bibtype = {article}, author = {Zwarenstein, M and Reeves, S}, journal = {The Journal of continuing education in the health professions}, number = {1} }
@article{kinzig_effects_2005-1, title = {The effects of human socioeconomic status and cultural characteristics on urban patterns of biodiversity}, volume = {10}, abstract = {We present evidence that there can be substantial variation in species richness in residential areas differing in their socioeconomic and cultural characteristics. Many analyses of the impacts of urbanization on biodiversity rely on traditional “urban-to-rural}, number = {1}, journal = {Ecology and Society}, author = {Kinzig, A. P. and Warren, P. S. and Martin, C. and Hope, D. and Katti, M.}, year = {2005}, keywords = {BES, biodiversity, urban, social aspects, human} }
@article{ title = {Mapping genes of complex psychiatric diseases in Daghestan genetic isolates}, type = {article}, year = {2005}, identifiers = {[object Object]}, keywords = {Chromosome Mapping,Chromosomes, Human, Pair 12/genetics,Chromosomes, Human, Pair 17/genetics,Chromosomes, Human, Pair 22/genetics,Chromosomes, Human, Pair 3/genetics,Female,Founder Effect,Genetic Predisposition to Disease/*genetics,Humans,Linkage Disequilibrium,Male,Mental Disorders/ethnology/*genetics,Microsatellite Repeats,Multivariate Analysis,Pedigree,Phenotype,Research Support, Non-U.S. Gov't,Russia,Schizophrenia/ethnology/genetics}, pages = {76-84}, volume = {132}, websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15389762}, id = {8f6c6132-b713-390e-b626-dfb026249513}, created = {2017-06-19T13:42:34.074Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:34.225Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>1552-4841 (Print)<m:linebreak/>Journal Article</m:note>}, abstract = {Genetic isolates, which provide outstanding opportunities for identification of susceptibility genes for complex diseases, can be classified as primary (having an ancient demographic history in a stable environment) or secondary (having a younger demographic history) Neel [1992: Minority populations: Genetics, demography, and health, pp. 1-13]. Daghestan contains 26 out of 50 indigenous Caucasus ethnicities that have been in existence for hundreds of generations in the same highland region. The ethnic groups are subdivided into numerous primary isolates. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. These are expressed as inter-population differences in lifetime prevalence and features of certain complex clinical phenotypes and in patterns of genetic linkage and linkage disequilibrium (LD). Stable highland and ethnic-cultural environments have led to increased penetrance and a reduced number of phenocopies, which typically hamper the identification of any susceptibility genes for complex diseases. Owing to these characteristics of the primary isolates, a comparative linkage study in the primary isolates allows us to define the number of susceptibility genes for any complex disease and to identify the source of variability and non-replication of linkage analysis results. As part of an ongoing study, seven extended schizophrenia and one nonspecific mental retardation kindreds have been ascertained from Daghestan isolates. Lifetime morbid risk for schizophrenia in the isolates varied from 0 to 5%. A genome scan with markers spaced 10 cM apart was carried out on these pedigrees and linkage analysis was performed using descent graph methods, as implemented in Simwalk2. To identify regions containing susceptibility genes within these kindreds, we followed up those regions with non-parametric and parametric linkage analyses, with the choice of genetic model guided by the results obtained in the NPL. While the analyses are ongoing, the most positive findings were made in different isolated pedigrees on chromosomes 17p11, 3q24, and 22q for schizophrenia and on chromosome 12q for nonspecific mental retardation.}, bibtype = {article}, author = {Bulayeva, K B and Leal, S M and Pavlova, T A and Kurbanov, R M and Glatt, S J and Bulayev, O A and Tsuang, M T}, journal = {Am J Med Genet B Neuropsychiatr Genet}, number = {1} }
@article{chen_over_2004, title = {Over 20\% of human transcripts might form sense-antisense pairs.}, volume = {32}, issn = {1362-4962}, url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=519112&tool=pmcentrez&rendertype=abstract}, doi = {10.1093/nar/gkh818}, abstract = {The major challenge to identifying natural sense- antisense (SA) transcripts from public databases is how to determine the correct orientation for an expressed sequence, especially an expressed sequence tag sequence. In this study, we established a set of very stringent criteria to identify the correct orientation of each human transcript. We used these orientation-reliable transcripts to create 26 741 transcription clusters in the human genome. Our analysis shows that 22\% (5880) of the human transcription clusters form SA pairs, higher than any previous estimates. Our orientation-specific RT-PCR results along with the comparison of experimental data from previous studies confirm that our SA data set is reliable. This study not only demonstrates that our criteria for the prediction of SA transcripts are efficient, but also provides additional convincing data to support the view that antisense transcription is quite pervasive in the human genome. In-depth analyses show that SA transcripts have some significant differences compared with other types of transcripts, with regard to chromosomal distribution and Gene Ontology-annotated categories of physiological roles, functions and spatial localizations of gene products.}, number = {16}, journal = {Nucleic acids research}, author = {Chen, Jianjun and Sun, Miao and Kent, W James and Huang, Xiaoqiu and Xie, Hanqing and Wang, Wenquan and Zhou, Guolin and Shi, Run Zhang and Rowley, Janet D}, month = jan, year = {2004}, pmid = {15356298}, keywords = {Antisense, Antisense: analysis, Antisense: chemistry, Antisense: genetics, Base Pairing, Chromosomes, Genetic, Genome, Human, Humans, Messenger, Messenger: chemistry, RNA, Reverse Transcriptase Polymerase Chain Reaction, Transcription}, pages = {4812--20} }
@article{ title = {Effectiveness and efficiency of guideline dissemination and implementation strategies}, type = {article}, year = {2004}, identifiers = {[object Object]}, keywords = {Cochrane Library,EMBASE,MEDLINE,United Kingdom,clinical practice,clinical research,cost benefit analysis,cost effectiveness analysis,education,epidemiology,feasibility study,health care organization,health care personnel,health care planning,health care policy,health economics,health survey,human,information dissemination,information retrieval,medical audit,medical decision making,practice guideline,primary medical care,register,review}, pages = {iii-72}, volume = {8}, websites = {http://www.scopus.com/inward/record.url?eid=2-s2.0-10744224331&partnerID=40&md5=3c257899cd02a20f42bae7e74745d8b2}, city = {Affiliation: Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom; Affiliation: Health Economics Research Unit, University of Aberdeen, Aberdeen, United Kingdom; Affiliation: Dept. of Epidemiology/Public Health, University of Ne}, id = {f9c473fa-9431-320d-9e25-c5cf0ccc5bb0}, created = {2016-08-21T22:17:35.000Z}, file_attached = {false}, profile_id = {217ced55-4c79-38dc-838b-4b5ea8df5597}, group_id = {408d37d9-5f1b-3398-a9f5-5c1a487116d4}, last_modified = {2017-03-14T09:54:45.334Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {JOUR}, notes = {Cited By (since 1996): 851}, folder_uuids = {028056a6-dab5-46a4-b9bf-02542e7cfa2b}, private_publication = {false}, abstract = {Objectives: To undertake a systematic review of the effectiveness and costs of different guideline development, dissemination and implementation strategies. To estimate the resource implications of these strategies. To develop a framework for deciding when it is efficient to develop anal introduce clinical guidelines. Data sources: Medline, Healthstar, Cochrane Controlled Trial Register, EMBASE, SIGLE and the specialised register of the Cochrane Effective Practice and Organisation of Care (EPOC) group. Review methods: Single estimates of dichotomous process variables were derived for each study comparison based upon the primary end-point or the median measure across several reported end-points. Separate analyses were undertaken for comparisons of different types of intervention. The study also explored whether the effects of multifaceted interventions increased with the number of intervention components. Studies reporting economic data were also critically appraised. A survey to estimate the feasibility and likely resource requirements of guideline dissemination and implementation strategies in UK settings was carried out with key informants from primary and secondary care. Results: In total, 235 studies reporting 309 comparisons met the inclusion criteria; of these 73% of comparisons evaluated multifaceted interventions, although the maximum number of replications of a specific multifaceted intervention was 11 comparisons. Overall, the majority of comparisons reporting dichotomous process data observed improvements in care; however, there was considerable variation in the observed effects both within and across interventions. Commonly evaluated single interventions were reminders, dissemination of educational materials, and audit and feedback. There were 23 comparisons of multifaceted interventions involving educational outreach. The majority of interventions observed modest to moderate improvements in care. No relationship was found between the number of component interventions and the effects of multifaceted interventions. Only 29.4% of comparisons reported any economic data. The majority of studies only reported costs of treatment; only 25 studies reported data on the costs of guideline development or guideline dissemination and implementation. The majority of studies used process measures for their primary end-point, despite the fact that only three guidelines were explicitly evidence based (and may not have been efficient). Respondents to the key informant survey rarely identified existing budgets to support guideline dissemination and implementation strategies. In general, the respondents thought that only dissemination of educational materials and short (lunchtime) educational meetings were generally feasible within current resources. Conclusions: There is an imperfect evidence base to support decisions about which guideline dissemination and implementation strategies are likely to be efficient under different circumstances. Decision makers need to use considerable judgement about how best to use the limited resources they have for clinical governance and related activities to maximise population benefits. They need to consider the potential clinical areas for clinical effectiveness activities, the likely benefits and costs required to introduce guidelines and the likely benefits and costs as a result of any changes in provider behaviour. Further research is required to: develop and validate a coherent theoretical framework of health professional and organisational behaviour and behaviour change to inform better the choice of interventions in research and service settings, and to estimate the efficiency of dissemination and implementation strategies in the presence of different barriers and effect modifiers. © Queen's Printer and Controller of HMSO 2004. All rights reserved.}, bibtype = {article}, author = {Grimshaw, J M and Thomas, R E and MacLennan, G and Fraser, C and Ramsay, C R and Vale, L and Whitty, P and Eccles, M P and Matowe, L and Shirran, L and Wensing, M and Dijkstra, R and Donaldson, C}, journal = {Health technology assessment}, number = {6} }
@article{ title = {Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: evolutionary and demographic evidence.}, type = {article}, year = {2004}, identifiers = {[object Object]}, keywords = {Americas,Americas: epidemiology,Anthropology, Physical,Biological Evolution,Chromosomes, Human, Y,Chromosomes, Human, Y: genetics,DNA, Mitochondrial,DNA, Mitochondrial: genetics,DNA, Mitochondrial: history,Demography,Emigration and Immigration,Emigration and Immigration: history,Genetic Variation,Genetics, Population,Haplotypes,Haplotypes: genetics,History, Ancient,History, Early Modern 1451-1600,Humans,Indians, North American,Indians, North American: genetics,Indians, North American: history,Siberia,Siberia: ethnology}, pages = {420-39}, volume = {16}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/15214060}, id = {6115f219-4d19-3554-a306-d8479c2786a2}, created = {2017-06-19T13:41:23.972Z}, accessed = {2012-10-24}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:41:24.152Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {A number of important insights into the peopling of the New World have been gained through molecular genetic studies of Siberian and Native American populations. While there is no complete agreement on the interpretation of the mitochondrial DNA (mtDNA) and Y chromosome (NRY) data from these groups, several generalizations can be made. To begin with, the primary migration of ancestral Asians expanded from south-central Siberia into the New World and gave rise to ancestral Amerindians. The initial migration seems to have occurred between 20,000-15,000 calendar years before present (cal BP), i.e., before the emergence of Clovis lithic sites (13,350-12,895 cal BP) in North America. Because an interior route through northern North America was unavailable for human passage until 12,550 cal BP, after the last glacial maximum (LGM), these ancestral groups must have used a coastal route to reach South America by 14,675 cal BP, the date of the Monte Verde site in southern Chile. The initial migration appears to have brought mtDNA haplogroups A-D and NRY haplogroups P-M45a and Q-242/Q-M3 to the New World, with these genetic lineages becoming widespread in the Americas. A second expansion that perhaps coincided with the opening of the ice-free corridor probably brought mtDNA haplogroup X and NRY haplogroups P-M45b, C-M130, and R1a1-M17 to North and Central America. Finally, populations that formerly inhabited Beringia expanded into northern North America after the LGM, and gave rise to Eskimo-Aleuts and Na-Dené Indians.}, bibtype = {article}, author = {Schurr, Theodore G and Sherry, Stephen T}, journal = {American journal of human biology : the official journal of the Human Biology Council}, number = {4} }
@article{ title = {A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor.}, type = {article}, year = {2003}, identifiers = {[object Object]}, keywords = {Adult,Chromosomes, Human, Pair 22,Ependymoma,Ependymoma: diagnosis,Ependymoma: genetics,Female,Genes, Neurofibromatosis 2,Germ-Line Mutation,Humans,Loss of Heterozygosity,Male,Microsatellite Repeats,Pedigree,Spinal Neoplasms,Spinal Neoplasms: genetics}, pages = {598-602}, volume = {48}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/14566482}, month = {1}, id = {27bbabe4-815b-349a-bf02-494ff0fc34a0}, created = {2014-08-02T22:29:07.000Z}, accessed = {2014-08-02}, file_attached = {true}, profile_id = {be299c88-7105-3a8d-a1cd-3aa95c25e2c4}, group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2}, last_modified = {2014-12-29T21:45:19.000Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {Familial ependymal tumors are a very rare disease, the pathogenesis of which is unknown. Previous studies indicate an involvement of tumor suppressor genes localized within chromosomal region 22q, whereas details are still unclear. Here we report a non-neurofibromatosis type-2 (non-NF2) Japanese family in which two of the four members are affected with cervical spinal cord ependymoma, and one of the four is affected with schwannoma. Loss of heterozygosity (LOH) studies were carried out searching for common allelic loss at chromosomal region 22q11.2-qtel in two of the affected patients. Our findings support a prediction for existence of a tumor suppressor gene on chromosome 22 especially related to the tumorigenesis of familial ependymal tumors.}, bibtype = {article}, author = {Yokota, Takashi and Tachizawa, Takayuki and Fukino, Koichi and Teramoto, Akira and Kouno, Jun and Matsumoto, Koshi and Emi, Mitsuru}, journal = {Journal of human genetics}, number = {11} }
@article{ title = {Reduced Y-chromosome, but not mitochondrial DNA, diversity in human populations from West New Guinea}, type = {article}, year = {2003}, identifiers = {[object Object]}, keywords = {*DNA, Mitochondrial/analysis,*Genetic Variation,Chromosomes, Human, Y/*genetics,Gene Frequency,Genetic Markers,Haplotypes,Humans,Indonesia,Male,Pacific Islands,Papua New Guinea,Tandem Repeat Sequences}, pages = {281-302}, volume = {72}, websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12532283}, edition = {2003/01/18}, id = {728c0553-adbc-3116-a081-bec19690cfaa}, created = {2017-06-19T13:43:47.781Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:43:47.930Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, language = {eng}, notes = {<m:note>Kayser, Manfred<m:linebreak/>Brauer, Silke<m:linebreak/>Weiss, Gunter<m:linebreak/>Schiefenhovel, Wulf<m:linebreak/>Underhill, Peter<m:linebreak/>Shen, Peidong<m:linebreak/>Oefner, Peter<m:linebreak/>Tommaseo-Ponzetta, Mila<m:linebreak/>Stoneking, Mark<m:linebreak/>Comparative Study<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>United States<m:linebreak/>American journal of human genetics<m:linebreak/>S0002-9297(07)60539-4<m:linebreak/>Am J Hum Genet. 2003 Feb;72(2):281-302. Epub 2002 Jan 16.</m:note>}, abstract = {To investigate the paternal population history of New Guinea, 183 individuals from 11 regional populations of West New Guinea (WNG) and 131 individuals from Papua New Guinea (PNG) were analyzed at 26 binary markers and seven short-tandem-repeat loci from the nonrecombining part of the human Y chromosome and were compared with 14 populations of eastern and southeastern Asia, Polynesia, and Australia. Y-chromosomal diversity was low in WNG compared with PNG and with most other populations from Asia/Oceania; a single haplogroup (M-M4) accounts for 75% of WNG Y chromosomes, and many WNG populations have just one Y haplogroup. Four Y-chromosomal lineages (haplogroups M-M4, C-M208, C-M38, and K-M230) account for 94% of WNG Y chromosomes and 78% of all Melanesian Y chromosomes and were identified to have most likely arisen in Melanesia. Haplogroup C-M208, which in WNG is restricted to the Dani and Lani, two linguistically closely related populations from the central and western highlands of WNG, was identified as the major Polynesian Y-chromosome lineage. A network analysis of associated Y-chromosomal short-tandem-repeat haplotypes suggests two distinct population expansions involving C-M208--one in New Guinea and one in Polynesia. The observed low levels of Y-chromosome diversity in WNG contrast with high levels of mtDNA diversity reported for the same populations. This most likely reflects extreme patrilocality and/or biased male reproductive success (polygyny). Our data further provide evidence for primarily female-mediated gene flow within the highlands of New Guinea but primarily male-mediated gene flow between highland and lowland/coastal regions.}, bibtype = {article}, author = {Kayser, M and Brauer, S and Weiss, G and Schiefenhovel, W and Underhill, P and Shen, P and Oefner, P and Tommaseo-Ponzetta, M and Stoneking, M}, journal = {Am J Hum Genet}, number = {2} }
@article{ title = {A Tough Lesson on Medical Privacy: Pakistani Transcriber Threatens UCSF Over Back Pay}, type = {article}, year = {2003}, keywords = {fixnot-doi,fixnot-number,fixnot-volume,healthcare,human,privacy,threats}, pages = {A1+}, websites = {http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2003/10/22/MNGCO2FN8G1.DTL}, month = {10}, id = {e6646f6f-0e3c-301c-946b-0598331186a6}, created = {2018-07-12T21:32:12.018Z}, file_attached = {false}, profile_id = {f954d000-ce94-3da6-bd26-b983145a920f}, group_id = {b0b145a3-980e-3ad7-a16f-c93918c606ed}, last_modified = {2018-07-12T21:32:12.018Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, citation_key = {lazarus:lesson}, source_type = {article}, private_publication = {false}, abstract = {A woman in Pakistan doing cut-rate clerical work for UCSF Medical Center threatened to post patients' confidential files on the Internet unless she was paid more money. To show she was serious, the woman sent UCSF an e-mail earlier this month with actual patients' records attached.}, bibtype = {article}, author = {Lazarus, David}, journal = {The San Francisco Chronicle} }
@article{ title = {Linkage disequilibrium and the mapping of complex human traits}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {*Linkage Disequilibrium,Chromosome Mapping,Genetics, Population,Genome, Human,Haplotypes,Human,Support, U.S. Gov't, P.H.S.}, pages = {19-24}, volume = {18}, id = {7d822191-046f-3d40-ba67-325d8361f589}, created = {2017-06-19T13:45:30.585Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:30.763Z}, tags = {03/07/22}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article</m:note>}, abstract = {The potential value of haplotypes defined by several single nucleotide polymorphisms has attracted recent interest. With sufficient linkage disequilibrium (LD), haplotypes could be used in association studies to map common alleles that might influence the susceptibility to common diseases, as well as for reconstructing the evolution of the genome. It has been proposed that a globally useful resource need only be based on high frequency variants, identified from a few modest samples. Rapid progress has been made in quantifying the pattern of human LD and haplotypes defined by such common variants within and among populations. However, the quality and utility of the proposed LD-based resource could be seriously compromised if important sampling and analytical factors are overlooked in its design. The LD map should be based on adequately justified criteria defined by sound population genetic principles.}, bibtype = {article}, author = {Weiss, K M and Clark, A G}, journal = {Trends Genet}, number = {1} }
@article{ title = {Fine-scale mapping of disease loci via shattered coalescent modeling of genealogies}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {*Pedigree,Algorithms,Alleles,Bayes Theorem,Bias (Epidemiology),Case-Control Studies,Chromosome Mapping/*methods/statistics & numerical,Computer Simulation,Cystic Fibrosis Transmembrane Conductance Regulato,Cystic Fibrosis/*genetics,Female,Genetic Heterogeneity,Genetic Markers/genetics,Haplotypes/genetics,Human,Linkage Disequilibrium/genetics,Male,Markov Chains,Models, Genetic,Monte Carlo Method,Mutation/genetics,Phylogeny,Probability,Recombination, Genetic/genetics,Sequence Deletion,Support, Non-U.S. Gov't}, pages = {686-707.}, volume = {70}, id = {b7168238-9085-3a82-81a6-a75268e0c428}, created = {2017-06-19T13:42:46.478Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:46.621Z}, tags = {02/04/26}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {We present a Bayesian, Markov-chain Monte Carlo method for fine-scale linkage-disequilibrium gene mapping using high-density marker maps. The method explicitly models the genealogy underlying a sample of case chromosomes in the vicinity of a putative disease locus, in contrast with the assumption of a star-shaped tree made by many existing multipoint methods. Within this modeling framework, we can allow for missing marker information and for uncertainty about the true underlying genealogy and the makeup of ancestral marker haplotypes. A crucial advantage of our method is the incorporation of the shattered coalescent model for genealogies, allowing for multiple founding mutations at the disease locus and for sporadic cases of disease. Output from the method includes approximate posterior distributions of the location of the disease locus and population-marker haplotype proportions. In addition, output from the algorithm is used to construct a cladogram to represent genetic heterogeneity at the disease locus, highlighting clusters of case chromosomes sharing the same mutation. We present detailed simulations to provide evidence of improvements over existing methodology. Furthermore, inferences about the location of the disease locus are shown to remain robust to modeling assumptions.}, bibtype = {article}, author = {Morris, A P and Whittaker, J C and Balding, D J}, journal = {Am J Hum Genet}, number = {3} }
@article{farley_envisioning_2002, title = {Envisioning shared goals for humanity: a detailed shared vision of a sustainable and desirable {USA} in 2100}, volume = {43}, abstract = {Economics has been defined as the science of allocation of scarce resources towards alternative ends. This definition implies that the first step in economic analysis is to determine what ends are desirable for society. Most sectors of the society would agree that sustainability is a desirable end, but there is little agreement as to what a sustainable future would look like. The University of Maryland Institute for Ecological Economics sponsored a democratic future search process designed to create a relatively detailed, shared vision of a sustainable and desirable USA in the year 2100. This paper presents the vision developed at that conference, examines the resources required to achieve the vision, and assesses the suitability of market mechanisms for allocating the required resources towards the desired ends. We find that markets are not efficient mechanisms for allocation in this case, and propose the institutions of a ‘strong democracy’ as a promising alternative.}, journal = {Ecological Economics}, author = {Farley, J. and Costanza, R.}, year = {2002}, keywords = {BES, human, sustainable development} }
@article{ title = {What is the Birth Defect Risk Associated With Consanguineous Marriages ?}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {*Consanguinity,Abnormalities/*genetics,Child,Female,Human,Infant,Male,Preschool,Risk Factors}, pages = {70-71}, volume = {109}, id = {f8021355-3e47-3c4b-b4f4-b8bb58d6fc41}, created = {2017-06-19T13:42:00.462Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:00.784Z}, tags = {04/11/22}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note> <m:bold>From Duplicate 1 ( </m:bold> <m:bold> </m:bold><m:bold><m:italic>What is the birth defect risk associated with consanguineous marriages?</m:italic></m:bold><m:bold> </m:bold> <m:bold> - Zlotogora, J )<m:linebreak/> </m:bold> <m:linebreak/>Case Reports<m:linebreak/>Letter<m:linebreak/> <m:linebreak/> </m:note>}, bibtype = {article}, author = {Zlotogora, Joël}, journal = {American journal of medical genetics}, number = {1} }
@article{ title = {Y-chromosome analysis in Egypt suggests a genetic regional continuity in Northeastern Africa}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {Arabs,Arabs: genetics,Chromosomes,Egypt,Emigration and Immigration,Emigration and Immigration: statistics & numerical,Gene Frequency,Gene Frequency: genetics,Genetic,Genetic Variation,Genetic Variation: genetics,Genetic: genetics,Genetics,Geography,Haplotypes,Haplotypes: genetics,Human,Humans,Morocco,Multivariate Analysis,Polymorphism,Population,Transients and Migrants,Transients and Migrants: statistics & numerical da,Y,Y: genetics}, pages = {645-658}, volume = {74}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/12495079}, month = {10}, id = {685d43bb-d61c-37f1-bdce-b022d0e2e246}, created = {2017-06-19T13:42:00.980Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:01.135Z}, tags = {03/05/15}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note> <m:bold>From Duplicate 1 ( </m:bold> <m:bold> </m:bold><m:bold><m:italic>Y-chromosome analysis in Egypt suggests a genetic regional continuity in Northeastern Africa</m:italic></m:bold><m:bold> </m:bold> <m:bold> - Manni, F; Leonardi, P; Barakat, A; Rouba, H; Heyer, E; Klintschar, M; McElreavey, K; Quintana-Murci, L )<m:linebreak/> </m:bold> <m:linebreak/>Journal Article<m:linebreak/> <m:linebreak/> </m:note>}, abstract = {The geographic location of Egypt, at the interface between North Africa, the Middle East, and southern Europe, prompted us to investigate the genetic diversity of this population and its relationship with neighboring populations. To assess the extent to which the modern Egyptian population reflects this intermediate geographic position, ten Unique Event Polymorphisms (UEPs), mapping to the nonrecombining portion of the Y chromosome, have been typed in 164 Y chromosomes from three North African populations. The analysis of these binary markers, which define 11 Y-chromosome lineages, were used to determine the haplogroup frequencies in Egyptians, Moroccan Arabs, and Moroccan Berbers and thereby define the Y-chromosome background in these regions. Pairwise comparisons with a set of 15 different populations from neighboring European, North African, and Middle Eastern populations and geographic analysis showed the absence of any significant genetic barrier in the eastern part of the Mediterranean area, suggesting that genetic variation and gene flow in this area follow the "isolation-by-distance" model. These results are in sharp contrast with the observation of a strong north-south genetic barrier in the western Mediterranean basin, defined by the Gibraltar Strait. Thus, the Y-chromosome gene pool in the modern Egyptian population reflects a mixture of European, Middle Eastern, and African characteristics, highlighting the importance of ancient and recent migration waves, followed by gene flow, in the region.}, bibtype = {article}, author = {Manni, Franz and Leonardi, Pascal and Barakat, Abdelhamid and Rouba, Hassan and Heyer, Evelyne and Klintschar, Michael and McElreavey, Ken and Quintana-Murci, Lluís}, journal = {Human biology}, number = {5} }
@article{ title = {Human evolution: tangled genetic routes}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {*Evolution,Africa,Evolution, Molecular,Genetics, Medical,Human,Software,Variation (Genetics)}, pages = {32-3.}, volume = {416}, id = {526659db-7b1d-3f19-99bb-b74e2e63e957}, created = {2017-06-19T13:45:19.925Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:20.098Z}, tags = {02/04/26}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Comment<m:linebreak/>News</m:note>}, bibtype = {article}, author = {Cann, R L}, journal = {Nature}, number = {6876} }
@article{ title = {Human mutation--blame (mostly) men}, type = {article}, year = {2002}, identifiers = {[object Object]}, keywords = {*Mutation,Animal,Comparative Study,DNA/genetics,Evolution,Female,Genetic,Human,Male,Models,Molecular,Polymorphism (Genetics),Primates/genetics,RNA-Binding Proteins/genetics,X Chromosome/*genetics,Y Chromosome/*genetics}, pages = {9-10.}, volume = {31}, id = {61983c7d-2056-316b-bd71-9cf44d9c9a9e}, created = {2017-06-19T13:42:10.378Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:10.525Z}, tags = {02/06/17}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>News</m:note>}, bibtype = {article}, author = {Ellegren, H}, journal = {Nat Genet}, number = {1} }
@article{ title = {Harvesting the fruits of the human genome}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {*Genome,Gene Expression,Genetic Techniques,Human,Human Genome Project,Oligonucleotide Array Sequence Analysis,Polymorphism,Single Nucleotide}, pages = {227-8.}, volume = {27}, id = {bd123f8b-9bfd-34a8-9c41-b68042248e9d}, created = {2017-06-19T13:42:23.436Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:23.560Z}, tags = {01/11/30}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Comment<m:linebreak/>Editorial<m:linebreak/>Review<m:linebreak/>Review, Tutorial</m:note>}, bibtype = {article}, author = {Editorial, undefined}, journal = {Nat Genet}, number = {3} }
@article{ title = {Inbreeding in Gredos mountain range (Spain): contribution of multiple consanguinity and intervalley variation}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {*Consanguinity,Ethnic Groups/*genetics,Geography,Human,Probability,Socioeconomic Factors,Spain,Support, Non-U.S. Gov't,Time Factors}, pages = {249-70.}, volume = {73}, id = {cbd6acf1-d154-3cbf-8680-aafc30f04c2c}, created = {2017-06-19T13:42:23.243Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:23.412Z}, tags = {02/02/13}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {The present paper examines consanguineous marriages occurring between 1874 and 1975 in three valleys (Tormes, Alberche, and Tietar) in the Sierra de Gredos mountain range, Avila province, Spain. Information was obtained from parish registers of 42 localities, corresponding to a total of 41,696 weddings. Consanguineous marriages were defined as those up to the third degree of consanguinity (second cousins). From 1874 to 1975 the percentage of related mates was 4.45% and the inbreeding coefficient was 0.0011868 (for 1874 to 1917 corresponding figures up to the fourth degree were 16.44% and 0.00 19085, respectively). In order to ascertain the characteristics and evolution of mating patterns in Gredos, the contribution of each degree of kinship was analyzed as a whole and then for each valley separately. Regarding total consanguineous marriages in Gredos, there is a low frequency of uncle-niece matings (0.21%) and a first-second cousin mating ratio (C22/C33) of 0.23 (up to the third degree of consanguinity). Before 1918 multiple matings (i.e., those involving more than a single relationship) accounted for 19.16% of consanguineous marriages (up to the fourth degree). The observed frequencies of multiple consanguineous marriages was, on average, about twice that expected at random, and the proportion of such marriages to total inbreeding was 34.65%. The temporal change of the Gredos inbreeding pattern was characterized by a recent decrease; the highest inbreeding levels correspond to the period from 1915 to 1944. Finally, intervalley differences (maximum inbreeding coefficient in the Tormes, minimum in the Tietar) are interpreted considering the geography, population size, and population mobility for each valley}, bibtype = {article}, author = {Fuster, V and Jimenez, A M and Colantonio, S E}, journal = {Hum Biol}, number = {2} }
@article{ title = {Genomewide scans of complex human diseases: true linkage is hard to find.}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {Asthma,Asthma: genetics,Chromosome Mapping,Databases, Genetic,Diabetes Mellitus, Type 2,Diabetes Mellitus, Type 2: genetics,Disease,Genetic Linkage,Genetic Linkage: genetics,Genome, Human,Humans,Multifactorial Inheritance,Multifactorial Inheritance: genetics,Regression Analysis}, pages = {936-50}, volume = {69}, websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1274370&tool=pmcentrez&rendertype=abstract}, month = {11}, id = {5d3be54c-8b02-31dc-a3b4-3edb22218ebf}, created = {2017-06-19T13:41:50.038Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:41:50.188Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, abstract = {Many "complex" human diseases, which involve multiple genetic and environmental determinants, have increased in incidence during the past 2 decades. During the same time period, considerable effort and expense have been expended in whole-genome screens aimed at detection of genetic loci contributing to the susceptibility to complex human diseases. However, the success of positional cloning attempts based on whole-genome screens has been limited, and many of the fundamental questions relating to the genetic epidemiology of complex human disease remain unanswered. Both to review the success of the positional cloning paradigm as applied to complex human disease and to investigate the characteristics of the whole-genome scans undertaken to date, we created a database of 101 studies of complex human disease, which were found by a systematic Medline search (current as of December 2000). We compared these studies, concerning 31 different human complex diseases, with regard to design, methods, and results. The "significance" categorizations proposed by Lander and Kruglyak were used as criteria for the "success" of a study. Most (66.3% [n=67]) of the studies did not show "significant" linkage when the criteria of Lander and Kruglyak (1995) were used, and the results of studies of the same disease were often inconsistent. Our analyses suggest that no single study design consistently produces more-significant results. Multivariate analysis suggests that the only factors independently associated with increased study success are (a) an increase in the number of individuals studied and (b) study of a sample drawn from only one ethnic group. Positional cloning based on whole-genome screens in complex human disease has proved more difficult than originally had been envisioned; detection of linkage and positional cloning of specific disease-susceptibility loci remains elusive.}, bibtype = {article}, author = {Altmüller, J and Palmer, L J and Fischer, G and Scherb, H and Wjst, M}, journal = {American journal of human genetics}, number = {5} }
@article{ title = {Differences in disease frequency between Europeans and Polynesians: directions for future research into genetic risk factors}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {Cardiovascular Diseases/epidemiology/ethnology/gen,Communicable Diseases/epidemiology/ethnology/genet,Comparative Study,Cross-Sectional Studies,Ethnic Groups/*genetics,Europe,Female,Genetic Predisposition to Disease/*ethnology,Human,Male,Mental Disorders/epidemiology/ethnology/genetics,Neoplasms/epidemiology/ethnology/genetics,Polynesia,Respiratory Tract Infections/epidemiology/ethnolog,Risk Factors,Support, Non-U.S. Gov't}, pages = {129-56.}, volume = {8}, id = {d2b1e45e-388c-3f80-aade-5bb60895ae60}, created = {2017-06-19T13:43:59.928Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:44:00.074Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article<m:linebreak/>Review<m:linebreak/>Review, Academic</m:note>}, abstract = {The purpose of this review is to identify complex genetic diseases that might be common in Polynesian ethnic groups because of a high frequency of susceptibility genes. Since a number of Polynesian ethnic groups are descended from recent founder populations, they may be especially suitable for studies designed to identify these genes. We have reviewed the epidemiological literature looking for diseases that i) have a higher frequency in at least two Polynesian groups than in Europeans living in the same geographic areas, ii) are not at high frequency in Polynesia entirely because of high levels of known environmental risk factors, and iii) are known to be inherited in other ethnic groups. Twenty-one diseases fulfilling these three criteria were identified. It may be possible to design studies to identify the genes that cause these diseases in Polynesian ethnic groups.}, bibtype = {article}, author = {Abbott, W and Scragg, R and Marbrook, J}, journal = {Pac Health Dialog}, number = {1} }
@article{ title = {After BRCA1 and BRCA2-what next? Multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {Age Factors,Age of Onset,Australia,BRCA1 Protein/*genetics,BRCA2 Protein,Breast Neoplasms/*genetics,Cohort Studies,Family Health,Female,Heterozygote,Human,Male,Models, Genetic,Molecular Sequence Data,Mutation,Neoplasm Proteins/*genetics,Pedigree,Probability,Risk Factors,Statistics,Support, Non-U.S. Gov't,Support, U.S. Gov't, P.H.S.,Transcription Factors/*genetics}, pages = {420-31.}, volume = {68}, id = {23f12ce0-3889-312a-be6e-926c320ad4f9}, created = {2017-06-19T13:45:18.919Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:19.048Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Mutations in BRCA1 and BRCA2 that cause a dominantly inherited high risk of female breast cancer seem to explain only a small proportion of the aggregation of the disease. To study the possible additional genetic components, we conducted single-locus and two-locus segregation analyses, with and without a polygenic background, using three-generation families ascertained through 858 women with breast cancer diagnosed at age <40 years, ascertained through population cancer registries in Melbourne and Sydney, Australia. Extensive testing for deleterious mutations in BRCA1 and BRCA2, to date, has identified 34 carriers. Our analysis suggested that, after other possible unmeasured familial factors are adjusted for and the known BRCA1 and BRCA2 mutation carriers are excluded, there appears to be a residual dominantly inherited risk of female breast cancer in addition to that derived from mutations in BRCA1 and BRCA2. This study also suggests that there is a substantial recessively inherited risk of early-onset breast cancer. According to the best-fitting model, after excluding known carriers of mutations in BRCA1 and BRCA2, about 1/250 (95% confidence interval [CI] 1/500 to 1/125) women have a recessive risk of 86% (95% CI 69%-100%) by age 50 years and of almost 100% by age 60 years. Possible reasons that our study has implicated a novel strong recessive effect include our inclusion of data on lineal aunts and grandmothers, study of families ascertained through women with early-onset breast cancer, allowance for multiple familial factors in the analysis, and removal of families for whom the cause (i.e., BRCA1 or BRCA2) is known. Our findings may have implications for attempts to identify new breast cancer-susceptibility genes.}, bibtype = {article}, author = {Cui, J and Antoniou, A C and Dite, G S and Southey, M C and Venter, D J and Easton, D F and Giles, G G and McCredie, M R and Hopper, J L}, journal = {Am J Hum Genet}, number = {2} }
@article{ title = {Protecting Against Bad Air}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {*Agriculture,*Glucosephosphate Dehydrogenase Deficiency/epidemi,*Variation (Genetics),Animal,Child,Erythrocytes/enzymology/parasitology,Evolution,Falciparum/*enzymology/epidemiology/*gene,Genetic,Glucosephosphate Dehydrogenase/blood/*genetics/met,Haplotypes,Human,Immunity,Malaria,Microsatellite Repeats,Models,Natural/genetics,Plasmodium falciparum/physiology,Polymorphism,Polymorphism (Genetics),Prevalence,Restriction Fragment Length,Selection (Genetics)}, pages = {442-443}, volume = {293}, id = {e244ac6a-cafa-3de1-81ae-e83092bdc695}, created = {2017-06-19T13:42:01.571Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:01.713Z}, tags = {03/03/18}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note> <m:bold>From Duplicate 1 ( </m:bold> <m:bold> </m:bold><m:bold><m:italic>Malaria. Protecting against bad air</m:italic></m:bold><m:bold> </m:bold> <m:bold> - Luzzatto, L; Notaro, R )<m:linebreak/> </m:bold> <m:linebreak/>eng<m:linebreak/>Comment<m:linebreak/>Journal Article<m:linebreak/> <m:linebreak/> </m:note>}, bibtype = {article}, author = {Luzzatto, Lucio and Notaro, Rosario}, journal = {Science}, number = {July} }
@article{ title = {Genetic structures and linguistic boundaries in Italy: a microregional approach}, type = {article}, year = {2001}, identifiers = {[object Object]}, keywords = {*Genetics, Population,*Linguistics,*Names,*Population Dynamics,Geography,Human,Italy,Support, Non-U.S. Gov't}, pages = {335-347}, volume = {73}, id = {abb39776-f87a-32fd-831f-e740fb33df35}, created = {2017-06-19T13:45:53.644Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:53.790Z}, tags = {03/05/15}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article</m:note>}, abstract = {The amount of genetic data (sequences, gene frequencies, and isonymy) available for the Province of Ferrara, Italy, makes this area one of the world's best known. In an effort to infer the underlying demographic processes, we studied the province's population structure by comparing geological, palaeoclimatic, archeological, historical, and linguistic data. This multilevel approach allowed us to date some characteristics of the population structure from prehistoric times to the Roman and Middle Ages, and to detect overlapping biological, cultural, and geographic boundaries. To detect linguistic boundaries within this area we turned pronunciation differences into phonetic notation. We then computed pairwise distances by using methods for multiple genetic sequence analysis, in order to obtain a distance matrix of the overall pronunciation variability. This approach enabled us to test the association among linguistic, geographical, and genetic distance matrices using the same statistical tests. Results indicate that demographic phenomena can be traced in an area as small as the Province of Ferrara and that, on a microregional scale, recent events may have influenced important aspects of the overall genetic variation.}, bibtype = {article}, author = {Manni, F and Barrai, I}, journal = {Hum Biol}, number = {3} }
@article{ title = {Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast and/or ovarian cancer families from North-Eastern Poland}, type = {article}, year = {2000}, identifiers = {[object Object]}, keywords = {*Founder Effect,Adult,Aged,Aged, 80 and over,BRCA1 Protein/*genetics,BRCA2 Protein,Breast Neoplasms/*genetics,Female,Genetic Markers/genetics,Germ-Line Mutation/*genetics,Human,Male,Middle Age,Neoplasm Proteins/*genetics,Ovarian Neoplasms/*genetics,Poland,Support, Non-U.S. Gov't,Support, U.S. Gov't, P.H.S.,Transcription Factors/*genetics}, pages = {480-1.}, volume = {15}, id = {fffeb98c-4cdd-3ed3-a41a-4a351d41efdd}, created = {2017-06-19T13:44:22.272Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:44:22.379Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact of BRCA2 mutations in Poland, we have analyzed 25 high-risk breast and/or ovarian cancer families from North-Eastern Poland for mutations in all coding exons of the BRCA1 and BRCA2 genes, using combined heteroduplex analysis/SSCP followed by direct DNA sequence analysis. Out of 25 probands a total of five (20%) carried three recurrent BRCA1 mutations (300T>G, 3819del5, 5382insC). The 300T>G mutation accounted for 60% (3/5) of BRCA1 mutations and allelotyping suggested a common founder of this mutation. No unique mutations were found. In addition, we identified three BRCA2 (12%) mutations, one recurrent 4075delGT, and two novel frameshift mutations, 7327ins/dupl19 and 9068delA. We conclude that 30% of high-risk families from North-Eastern Poland may be due to recurrent BRCA1 and unique BRCA2 mutations. Intriguingly, the BRCA1 mutation spectrum seems to be different within subregions of Poland.}, bibtype = {article}, author = {van Der Looij, M and Wysocka, B and Brozek, I and Jassem, J and Limon, J and Olah, E}, journal = {Hum Mutat}, number = {5} }
@article{ title = {Why are the majority of hereditary cases of early-onset breast cancer sporadic? A simulation study}, type = {article}, year = {2000}, identifiers = {[object Object]}, keywords = {Adult,Age Distribution,Age of Onset,Aged,Australia/epidemiology,Breast Neoplasms/*epidemiology/ethnology/*genetics,Computer Simulation,Family Health,Female,Gene Frequency,Genes, BRCA1,Great Britain/epidemiology,Human,Jews/statistics & numerical data,Middle Age,Models, Genetic,Mutation,Pedigree,Prevalence,Singapore/epidemiology,Support, Non-U.S. Gov't,Support, U.S. Gov't, P.H.S.,Washington/epidemiology}, pages = {805-12.}, volume = {9}, id = {373ef46c-3714-3339-8c8d-5b9047cf28e7}, created = {2017-06-19T13:44:21.419Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:44:21.571Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Population-based studies, including those of Ashkenazi Jews, have observed that at least 50% of women with early-onset breast cancer who carry a germ line mutation in BRCA1 or BRCA2 do not report a family history of the disease. That is, the majority of "hereditary" cases are "sporadic." Furthermore, the great majority of "familial breast cancers" are not hereditary. We conducted a simulation study to evaluate the probability that a woman with early-onset breast cancer is a mutation carrier, given the number of affected relatives, for a range of plausible values of allele frequency (0.001-0.01), and increased risk in mutation carriers (5-20, equivalent to cumulative risks to age 70 of 25-70%, respectively, for Australian women). Families consisted of a case proband and her mother, sisters, and maternal and paternal grandmothers, and aunts. The numbers of sisters and aunts were generated according to Poisson distributions, and ages were assigned according to a Weibull distribution. The simulated distributions of family history and of the prevalence of mutation carriers among case probands were in general similar to those observed in population-based studies, although there was a suggestion of heterogeneity of breast cancer risk in mutation carriers. As is being observed empirically in population-based samples, a family history of breast cancer was not a strong predictor of mutation status; each affected female relative increased the risk of being a mutation carrier by only 2- to 3-fold. The probability of being a mutation carrier was generally low, except in families with extreme histories of breast cancer.}, bibtype = {article}, author = {Cui, J and Hopper, J L}, journal = {Cancer Epidemiol Biomarkers Prev}, number = {8} }
@article{ title = {The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes}, type = {article}, year = {2000}, identifiers = {[object Object]}, keywords = {*Chromosomes, Human, Pair 18,*Linkage Disequilibrium,Chromosome Mapping,Diabetes Mellitus, Insulin-Dependent/*genetics,Finland,Genotype,Human,Italy,Microsatellite Repeats,Polymorphism (Genetics),Support, Non-U.S. Gov't,Support, U.S. Gov't, P.H.S.}, pages = {320-3.}, volume = {25}, websites = {http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v25/n3/full/ng0700_320.html,http://www.nature.com/cgi-taf/DynaPage.taf?file=/ng/journal/v25/n3/abs/ng0700_320.html}, id = {9844ac6c-5555-3386-a968-ad5f8216a4bf}, created = {2017-06-19T13:44:56.225Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:44:56.367Z}, tags = {01/11/30}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {The choice of which population to study in the mapping of common disease genes may be critical. Isolated founder populations, such as that found in Finland, have already proved extremely useful for mapping the genes for specific rare monogenic disorders and are being used in attempts to map the genes underlying common, complex diseases. But simulation results suggest that, under the common disease-common variant hypothesis, most isolated populations will prove no more useful for linkage disequilibrium (LD) mapping of common disease genes than large outbred populations. There is very little empirical data to either support or refute this conclusion at present. Therefore, we evaluated LD between 21 common microsatellite polymorphisms on chromosome 18q21 in 2 genetic isolates (Finland and Sardinia) and compared the results with those observed in two mixed populations (United Kingdom and United States of America). Mean levels of LD were similar across all four populations. Our results provide empirical support for the expectation that genetic isolates like Finland and Sardinia will not prove significantly more valuable than general populations for LD mapping of common variants underlying complex disease.}, bibtype = {article}, author = {Eaves, I A and Merriman, T R and Barber, R A and Nutland, S and Tuomilehto-Wolf, E and Tuomilehto, J and Cucca, F and Todd, J A}, journal = {Nat Genet}, number = {3} }
@article{ title = {Familial cancer risks to offspring from mothers with 2 primary breast cancers: leads to cancer syndromes}, type = {article}, year = {2000}, identifiers = {[object Object]}, keywords = {Adolescence,Adult,Breast Neoplasms/epidemiology/*genetics,Child,Child, Preschool,Databases, Factual,Family Health,Female,Human,Incidence,Infant,Infant, Newborn,Male,Middle Age,Mothers,Neoplasms, Second Primary/epidemiology/*genetics,Neoplasms/epidemiology/*genetics,Risk Factors,Socioeconomic Factors,Support, Non-U.S. Gov't,Sweden/epidemiology}, pages = {87-91.}, volume = {88}, id = {588e6ac8-7072-3509-b985-6895b25455d2}, created = {2017-06-19T13:44:44.036Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:44:44.218Z}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {The nationwide Swedish Family-Cancer Database was used to analyse the risk of cancer among the offspring of bilateral breast cancer patients. We studied 4,734 such mothers who had 9,391 offspring, of whom 328 presented with a primary cancer in the years 1958-1996. Standardised incidence ratios (SIRs) were increased for breast [SIR 3.05, 95% confidence interval (CI) 2.57-3.59], ovarian (SIR 1.84, 95% CI 1.03-3.05) and anogenital (SIR 1.75, 95% CI 1.11-2.63) cancers and childhood sarcomas (SIR 9.39, 95% CI 1.93-29.13). Additionally, squamous-cell skin cancer was increased among sons and all childhood cancers among daughters. When analysed by histological type, adenocarcinomas of the breast and ovary, all squamous-cell carcinomas and tumours at glandular epithelium (seminomas and intestinal carcinoids) were increased. Mothers with bilateral breast cancer had an excess of 2 or more children with cancer. The increased risk of ovarian cancer is consistent with germline mutations in the BRCA1 and BRCA2 genes, while the risk of soft tissue and bone sarcomas may reflect the association of these tumours with Li-Fraumeni syndrome. The increases in squamous-cell carcinomas at many sites may reflect a new susceptibility syndrome.}, bibtype = {article}, author = {Hemminki, K and Vaittinen, P and Easton, D}, journal = {Int J Cancer}, number = {1} }
@article{ title = {Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry}, type = {article}, year = {1999}, identifiers = {[object Object]}, keywords = {Base Sequence,Canada,Canada/ethnology,Canada: ethnology,DNA-Binding Proteins,DNA-Binding Proteins/*genetics,DNA-Binding Proteins: genetics,Ethnic Groups,Ethnic Groups/*genetics,Ethnic Groups: genetics,Female,France,France/ethnology,France: ethnology,Human,Humans,Louisiana,Male,Microsatellite Repeats,Microsatellite Repeats/*genetics,Microsatellite Repeats: genetics,Muscular Dystrophies,Muscular Dystrophies/*genetics,Muscular Dystrophies: genetics,Non-U.S. Gov't,Pedigree,Poly(A)-Binding Protein II,Support}, pages = {477-481}, volume = {86}, websites = {http://www.ncbi.nlm.nih.gov/pubmed/10508991}, month = {10}, day = {29}, id = {45d065a8-6799-3e6b-880b-3fa24b3356fa}, created = {2017-06-19T13:42:02.365Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:02.505Z}, tags = {04/09/07}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note> <m:bold>From Duplicate 1 ( </m:bold> <m:bold> </m:bold><m:bold><m:italic>Unique PABP2 mutations in "Cajuns" suggest multiple founders of oculopharyngeal muscular dystrophy in populations with French ancestry</m:italic></m:bold><m:bold> </m:bold> <m:bold> - Scacheri, P C; Garcia, C; Hebert, R; Hoffman, E P )<m:linebreak/> </m:bold> <m:linebreak/>Journal Article<m:linebreak/> <m:linebreak/> </m:note>}, abstract = {Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset autosomal dominant myopathy found world-wide, but with the highest incidence in French-Canadians. Short GCG expansions in the poly(A) binding protein 2 (PABP2) gene were identified recently as the molecular basis for OPMD in French-Canadians. All French-Canadian cases of OPMD have been traced to a single founder couple [Bouchard, 1997: Neuromuscul Disord 7(Suppl):S5-S11]. Cultural links between French-Canadians and Cajuns suggest that this same founder couple may have transmitted the OPMD mutation to Cajuns as well. To determine if OPMD patients from Louisiana share a founder effect with French-Canadian families, we collected blood samples and muscle biopsies from several Cajuns with OPMD for mutation and linkage studies. We found a unique 'GCA GCG GCG' insertion mutation in Cajuns. Consistent with these sequence data, we identified a disease haplotype in our Cajun families that is different from the ancestral haplotype defined in French-Canadians. These data prove that different founders introduced the PABP2 mutation to Cajuns and French-Canadians and lend support to emerging genealogical data suggesting that French-Canadians and Cajuns represent distinct immigrant groups from France.}, bibtype = {article}, author = {Scacheri, P C and Garcia, C and Hébert, R and Hoffman, E P and Hebert, R}, journal = {Am J Med Genet}, number = {5} }
@article{ title = {Visual-proprioceptive mapping in children with developmental coordination disorder}, type = {article}, year = {1999}, identifiers = {[object Object]}, keywords = {Case-Control Studies,Child,Female,Growth Disorders,Humans,Male,Motor Skills,Preschool,Proprioception,Vision,physiopathology,psychology}, pages = {247-254}, volume = {41}, id = {2a1d6312-9620-3630-b63f-f17c2d8e07ef}, created = {2016-01-12T14:17:48.000Z}, file_attached = {false}, profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd}, last_modified = {2017-03-16T06:19:45.131Z}, read = {false}, starred = {false}, authored = {true}, confirmed = {true}, hidden = {false}, abstract = {Developmental coordination disorder (DCD) occurs in a small but significant proportion of children who present with impaired body-eye coordination and show poor acquisition of motor skills. This study investigated the visual-proprioceptive mapping ability of children with DCD from a small selected group, with particular reference to the use of vision in matching tasks. The children with DCD in this study were significantly poorer than control children on all matching tasks. They seemed to have particular difficulty in cross-modal judgements that required the use of visual information to guide proprioceptive judgements of limb position. A distinction is drawn between tasks that can be achieved purely through sensory matching and those that require body-centred spatial judgements, suggesting that it is the latter that posits a particular difficulty for children with DCD}, bibtype = {article}, author = {Mon-Williams, M A and Wann, J P and Pascal, E}, journal = {Developmental Medicine & Child Neurology}, number = {4} }
@article{ title = {The conceptual structure of research utilization}, type = {article}, year = {1999}, identifiers = {[object Object]}, id = {e8334dc3-a5a9-376c-ad94-9ea7843d072d}, created = {2016-12-15T22:52:55.000Z}, file_attached = {false}, profile_id = {369acd69-1fe7-313d-821e-cb7bbe1ddab2}, last_modified = {2017-03-25T14:39:59.517Z}, read = {false}, starred = {false}, authored = {true}, confirmed = {false}, hidden = {false}, private_publication = {false}, bibtype = {article}, author = {Estabrooks, C A} }
@article{ title = {Inbreeding effects on fertility in humans: evidence for reproductive compensation}, type = {article}, year = {1999}, identifiers = {[object Object]}, keywords = {*Consanguinity,Adult,Female,Fertility/*genetics,Human,Male,Maternal Age,Parity,Pregnancy,Pregnancy Outcome,Support, U.S. Gov't, P.H.S.,Survival Analysis}, pages = {225-231}, volume = {64}, id = {711dce5e-f621-38d7-b578-243db54df1d0}, created = {2017-06-19T13:45:55.794Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:55.913Z}, tags = {04/11/22}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article</m:note>}, abstract = {The effects of inbreeding on prereproductive mortality have been demonstrated in many natural populations, including humans. However, little is known about the effects in inbred individuals who survive to adulthood. We have investigated the effects of inbreeding on fertility among inbred adult Hutterites and demonstrate significantly reduced fecundity among the most inbred Hutterite women, as evidenced by longer interbirth intervals (P=.024) and longer intervals to a recognized pregnancy (P=.010) but not by increased rates of fetal loss (P>.50). These data suggest the presence of recessive alleles that adversely affect fecundity among the population. In contrast, completed family sizes do not differ among the more and the less-inbred Hutterite women who were born after 1920, suggesting that reproductive compensation is occurring among the more-inbred and less-fecund women. This recent reproductive strategy would facilitate the maintenance of recessive alleles and contribute to an overall decline in fertility in the population.}, bibtype = {article}, author = {Ober, C and Hyslop, T and Hauck, W W}, journal = {Am J Hum Genet}, number = {1} }
@article{ title = {Genetic epidemiology of single-nucleotide polymorphisms}, type = {article}, year = {1999}, identifiers = {[object Object]}, keywords = {*Evolution, Molecular,*Genetic Predisposition to Disease,*Linkage Disequilibrium,*Polymorphism, Restriction Fragment Length,Case-Control Studies,Chromosome Mapping,Cloning, Molecular/*methods,Gene Frequency,Genetic Heterogeneity,Haplotypes,Human,Racial Stocks/genetics,Time Factors}, pages = {15173-7.}, volume = {96}, id = {a6d87bce-f6a5-33f5-ae51-cbff9129ea59}, created = {2017-06-19T13:45:32.210Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:32.339Z}, tags = {02/12/05}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {On the causal hypothesis, most genetic determinants of disease are single-nucleotide polymorphisms (SNPs) that are likely to be selected as markers for positional cloning. On the proximity hypothesis, most disease determinants will not be included among markers but may be detected through linkage disequilibrium with other SNPs. In that event, allelic association among SNPs is an essential factor in positional cloning. Recent simulation based on monotonic population expansion suggests that useful association does not usually extend beyond 3 kb. This is contradicted by significant disequilibrium at much greater distances, with corresponding reduction in the number of SNPs required for a cost-effective genome scan. A plausible explanation is that cyclical expansions follow population bottlenecks that establish new disequilibria. Data on more than 1,000 locus pairs indicate that most disequilibria trace to the Neolithic, with no apparent difference between haplotypes that are random or selected through a major disease gene. Short duration may be characteristic of alleles contributing to disease susceptibility and haplotypes characteristic of particular ethnic groups. Alleles that are highly polymorphic in all ethnic groups may be older, neutral, or advantageous, in weak disequilibrium with nearby markers, and therefore less useful for positional cloning of disease genes. Significant disequilibrium at large distance makes the number of suitably chosen SNPs required for genome screening as small as 30,000, or 1 per 100 kb, with greater density (including less common SNPs) reserved for candidate regions.}, bibtype = {article}, author = {Collins, A and Lonjou, C and Morton, N E}, journal = {Proc Natl Acad Sci U S A}, number = {26} }
@article{ title = {Which of our genes makes us human?}, type = {article}, year = {1998}, keywords = {*Chromosomes, Human,*Genome,*Genome, Human,*Human Characteristics,*Sequence Analysis, DNA,Animal,Chromosome Mapping,Gene Expression,Human,Mutation,Pan troglodytes/genetics,Pongidae/*genetics,Sialic Acids/chemistry/physiology,Species Specificity}, pages = {1432-1434}, volume = {281}, id = {85b008be-1b1d-3c94-bd62-2d641fa111cc}, created = {2017-06-19T13:42:20.922Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:21.018Z}, tags = {03/11/21}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>News</m:note>}, bibtype = {article}, author = {Gibbons, A}, journal = {Science}, number = {5382} }
@article{ title = {Isonymy and the genetic structure of Switzerland. II. Isolation by distance}, type = {article}, year = {1998}, identifiers = {[object Object]}, keywords = {*Genetics, Population,*Names,Human,Support, Non-U.S. Gov't,Switzerland}, pages = {533-40.}, volume = {25}, id = {72003c35-a39f-3f4f-9304-3b9ab1179b6e}, created = {2017-06-19T13:45:55.271Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:55.408Z}, tags = {02/02/13}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Isolation by distance in Switzerland was detected comparing the surname distributions between Cantons. The decay of isonymy with geographic distance between Cantons was consistent with Malecot's exponential decay of kinship. Lasker's distance was defined as the negative value of the logarithm of isonymy between localities, and it was found that it is linearly and significantly correlated with the log of geographic distance, both within and between languages. The peculiar geographic and linguistic structure of the Confederation, where mountain barriers exist at short distances separating different languages, might explain the rapid changes in surname similarity. It was predicted that the frequency of markers linked to the Y chromosome would show a similar association with distance in Switzerland.}, bibtype = {article}, author = {Rodriguez-Larralde, A and Scapoli, C and Beretta, M and Nesti, C and Mamolini, E and Barrai, I}, journal = {Ann Hum Biol}, number = {6} }
@article{ title = {The twinning rates and epidemiological characteristics of births in southeast Uttar Pradesh, India}, type = {article}, year = {1997}, identifiers = {[object Object]}, keywords = {Adult,Birth Rate,Female,Human,India/epidemiology,Maternal Age,Parity,Pregnancy,Pregnancy Complications/*epidemiology,Pregnancy, Multiple/*statistics & numerical data,Seasons,Twins, Dizygotic,Twins, Monozygotic,Twins/*statistics & numerical data}, pages = {47-56}, volume = {46}, id = {529933bb-e6ef-3768-86f0-68daccc174e2}, created = {2017-06-19T13:43:38.550Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:43:38.682Z}, tags = {03/11/06}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article<m:linebreak/>Twin Study</m:note>}, abstract = {Birth statistics over a period of 5 years were analyzed to study epidemiological characteristics of twinning in Southeast Uttar Pradesh, India. The data revealed higher incidence of breech twins (11.84% of all cotwins) as compared to breech single births (2.18%). But the perinatal mortality and caesarean section rates were similar in both twin and singleton pregnancies. The cumulative twinning rate over the studied period was 11.70 per 1000 live births. The MZ and DZ twinning rates were estimated respectively as 3.67 and 8.03 per mill. The mean maternal age of sampled mothers was 26.42 years with one standard deviation of 5.30 years. The twinning rate for mothers over 35 years of age was about four times higher than that in mothers younger than 20 years. Incidentally, the twinning rate was the highest at parity four and a non-linear curve could more appropriately be fitted to the series of data. Seasonal variations were observed for both twin and singleton births. The highest frequency of births was observed from August through October. But seasonal index for twinning rate showed a clear bimodal distribution with peaks in April (223) and September (167).}, bibtype = {article}, author = {Sharma, K}, journal = {Acta Genet Med Gemellol (Roma)}, number = {1} }
@article{ title = {Expanding on population studies}, type = {article}, year = {1997}, identifiers = {[object Object]}, keywords = {*Genetic Predisposition to Disease,*Genetics, Population,*Linkage Disequilibrium,Alleles,Genetic Markers,Genome, Human,Human}, pages = {371-3.}, volume = {17}, id = {49e188c8-e080-33b5-a568-9fe94c8dc4a0}, created = {2017-06-19T13:44:57.078Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:44:57.203Z}, tags = {02/03/18}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Comment<m:linebreak/>News</m:note>}, bibtype = {article}, author = {Freimer, N B and Service, S K and Slatkin, M}, journal = {Nat Genet}, number = {4} }
@article{ title = {The heritability of happiness}, type = {article}, year = {1996}, identifiers = {[object Object]}, keywords = {*Genes,*Happiness,Chromosome Mapping,Human}, pages = {125-6.}, volume = {14}, id = {a34de1c6-d224-3664-9b15-aa17ba004a09}, created = {2017-06-19T13:43:59.225Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:43:59.319Z}, tags = {02/02/28}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>News</m:note>}, bibtype = {article}, author = {Hamer, D H}, journal = {Nat Genet}, number = {2} }
@article{ title = {The genetical archaeology of the human genome}, type = {article}, year = {1996}, identifiers = {[object Object]}, keywords = {*Gene Pool,*Genome, Human,DNA, Mitochondrial/genetics,Evolution, Molecular,Female,Human,Male,Models, Genetic,Phylogeny,Support, Non-U.S. Gov't,Variation (Genetics)/*genetics}, pages = {135-140}, volume = {14}, id = {da42c725-f648-32fa-a720-c48d07c5c47c}, created = {2017-06-19T13:46:05.495Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:46:05.676Z}, tags = {03/09/17}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>Journal Article<m:linebreak/>Review<m:linebreak/>Review, Tutorial</m:note>}, abstract = {Palaentology and archaeology are disciplines that traditionally deal with the reconstruction of human origins and history. Recently, however, molecular genetics has come to make increasing contributions to this area. In particular, several data sets indicate that variation of the human gene pool originated in Africa within the last 200,000 years. Furthermore, the study of DNA sequences allows the detection of expansions in population size. Here we briefly summarize and exemplify how DNA sequences can be used to reconstruct the history of populations.}, bibtype = {article}, author = {von Haeseler, A and Sajantila, A and Paabo, S}, journal = {Nat Genet}, number = {2} }
@article{ title = {Variability of the genetic contribution of Quebec population founders associated to some deleterious genes}, type = {article}, year = {1995}, identifiers = {[object Object]}, keywords = {*Variation (Genetics),Genes/*genetics,Genetic Diseases,Human,Inborn/*genetics,Non-U.S. Gov't,Quebec,Support}, pages = {970-8.}, volume = {56}, id = {aca70703-612e-37dc-ad8a-67357d5d675c}, created = {2017-06-19T13:45:32.514Z}, file_attached = {true}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:45:32.692Z}, tags = {03/06/15}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Relatively high frequencies of some rare inherited disorders can be found in the Saguenay Region (Quebec). To understand this phenomenon, a research project on the 17th-century founder effect that led to the formation of French Canadians' gene pool is being carried out. The focus of this study is on founders who contributed to the Saguenay gene pool and who are related to contemporary probands suffering from any one of five hereditary diseases: cystic fibrosis, tyrosinemia, hemochromatosis, Charlevoix-Saguenay spastic ataxia, and sensorimotor polyneuropathia with or without agenesis of the corpus callosum. A control group has been added for comparison purposes. Altogether, 545 ascending genealogies have been reconstructed, using the Interuniversity Institute for Population Research's RETRO database, leading to > 2,500 founders. The genetic contribution of each founder to each group has been measured. Results show that (1) nearly 80% of the individuals' gene pool come from founders who settled in Nouvelle-France in the 17th century, whatever the group; (2) 15% of the founders explain 90% of the total genetic contribution of the founders, but this pattern varies from one group to another; (3) there is no subgroup of founders more related to any given group of individuals.}, bibtype = {article}, author = {Heyer, E and Tremblay, M}, journal = {Am J Hum Genet}, number = {4} }
@article{ title = {Isolation by distance on the Island of Korcula: correlation analysis of distance measures}, type = {article}, year = {1988}, identifiers = {[object Object]}, keywords = {*Anthropometry,*Dermatoglyphics,*Genetics, Population,*Rural Population,*Social Environment,*Social Isolation,Female,Human,Male,Support, U.S. Gov't, Non-P.H.S.,Yugoslavia}, pages = {97-103.}, volume = {77}, id = {17517e63-11e9-3896-8f0a-960853e28e9c}, created = {2017-06-19T13:42:46.587Z}, file_attached = {false}, profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646}, group_id = {b2078731-0913-33b9-8902-a53629a24e83}, last_modified = {2017-06-19T13:42:46.723Z}, tags = {02/03/08}, read = {false}, starred = {false}, authored = {false}, confirmed = {true}, hidden = {false}, source_type = {Journal Article}, notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>}, abstract = {Within the framework of holistic anthropological investigations of the rural populations on the Island of Korcula, various measures of biological distances between eight villages were estimated (Mahalanobis' D2 for anthropometric, physiological, and dermatoglyphic traits); socio-cultural similarities and distances were determined (kinship coefficient estimated from migrational data and Hemming similarity measure estimated from linguistic data). A matrix of Spearman's rank correlation coefficients among these measures demonstrated a pattern of interdependencies, which we analysed further by principal components analysis. The first component reflects the cumulative effect of different processes acting on the initial gene distribution over a long period of time; the second component represents initial population structure; and the third component reflects recent migration influences.}, bibtype = {article}, author = {Rudan, P and Simic, D and Bennett, L A}, journal = {Am J Phys Anthropol}, number = {1} }