@article{rao_global_2022,
	title = {A {Global} {Survey} of {Ethnic} {Indian} {Women} {Living} with {Polycystic} {Ovary} {Syndrome}: {Co}-{Morbidities}, {Concerns}, {Diagnosis} {Experiences}, {Quality} of {Life}, and {Use} of {Treatment} {Methods}},
	volume = {19},
	issn = {1660-4601},
	shorttitle = {A {Global} {Survey} of {Ethnic} {Indian} {Women} {Living} with {Polycystic} {Ovary} {Syndrome}},
	doi = {10.3390/ijerph192315850},
	abstract = {BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is highly prevalent in women of Indian ethnicity. Clinical practice guidelines do not adequately consider ethnic-cultural differences in the diagnosing and care of women with PCOS. This study aimed to understand co-morbidities, key concerns, quality of life (QoL), and diagnosis experiences of ethnic Indian women living with PCOS.
METHODS: Global online survey of ethnic Indian women of reproductive age living with PCOS.
RESULTS: Respondents (n = 4409) had a mean age of 26.8 (SD 5.5) years and reported having a family history of type 2 diabetes (43\%) and PCOS (18\%). Most of them (64\%) were diagnosed with one or more co-morbidities (anxiety/depression being the most common). Irregular periods, cysts on the ovaries, and excess unwanted facial hair growth were their three top concerns. On average, women experienced symptoms of PCOS at the age of 19.0 (SD 5.0) and were diagnosed at the age of 20.8 years (SD 4.8). We report a one-year delay in seeking medical help and a seven-month diagnostic delay, which were associated with poor satisfaction with the information provided related to PCOS and its treatment options (p {\textless} 0.01). Women living outside India reported difficulty losing weight as their most key concern; however, they had higher dissatisfaction with the information provided on diet (OR, 0.74; 95\% CI, 0.6 to 0.8; p = 0.002), exercise (OR, 0.74; 95\% CI, 0.6 to 0.9; p = 0.002) and behavioural advice (OR, 0.74; 95\% CI, 0.6 to 0.9; p = 0.004) than women living in India. Most women reported poor QoL in weight and emotion domains.
CONCLUSIONS: Ethnic Indian women experience early onset of PCOS symptoms and delay in seeking professional help. Timely diagnosis, providing cultural-specific education related to lifestyle and weight management, and improving psycho-emotional support are key areas that should be addressed in clinical practice and future research.},
	language = {eng},
	number = {23},
	journal = {International Journal of Environmental Research and Public Health},
	author = {Rao, Vibhuti Samarth and Cowan, Stephanie and Armour, Mike and Smith, Caroline A. and Cheema, Birinder S. and Moran, Lisa and Lim, Siew and Gupta, Sabrina and Manincor, Michael De and Sreedhar, Vikram and Ee, Carolyn},
	month = nov,
	year = {2022},
	pmid = {36497927},
	pmcid = {PMC9740300},
	keywords = {Adult, Delayed Diagnosis, Diabetes Mellitus, Type 2, Female, Humans, Indian migrant women, Indian women, Menstruation Disturbances, PCOS, Polycystic Ovary Syndrome, Quality of Life, Young Adult, diagnosis, key concerns, polycystic ovary syndrome, quality of life, satisfaction, survey, treatment methods},
	pages = {15850},
}

@article{buckner_integrated_2021,
	title = {Integrated cognitive-behavioral therapy for comorbid cannabis use and anxiety disorders: {The} impact of severity of cannabis use},
	issn = {1936-2293(Electronic),1064-1297(Print)},
	shorttitle = {Integrated cognitive-behavioral therapy for comorbid cannabis use and anxiety disorders},
	doi = {10.1037/pha0000456},
	abstract = {Cannabis use disorder (CUD) is the most common illicit substance use disorder and individuals with CUD have high rates of comorbid anxiety disorders. Comorbidity between CUD and anxiety disorders is of public health relevance given that although motivation enhancement therapy (MET) combined with cognitive-behavioral therapy (CBT) is an efficacious intervention for CUD, outcomes are worse for patients with elevated anxiety. Integrated cannabis and anxiety reduction treatment (ICART) was developed based on translational research; it integrates a transdiagnostic CBT for anxiety disorders with MET/cognitive behavior therapy (MET-CBT) for CUD, with outcomes comparable to MET-CBT alone. The current study tested whether ICART is more efficacious than MET-CBT alone for patients with more severe baseline cannabis use and use-related problems. Individuals seeking treatment for CUD (56.4\% male, Mage = 23.2, 63.3\% non-Hispanic White) with at least one comorbid anxiety disorder were randomly assigned to ICART (n = 27) or MET-CBT (n = 28). Baseline severity of cannabis use and use-related problems moderated the relation between condition and posttreatment outcomes, such that among patients with the greatest baseline cannabis use, ICART was associated with less posttreatment cannabis use than MET-CBT alone. Further, among those with the greatest number of cannabis-related problems, patients in ICART reported fewer posttreatment problems than those in the MET-CBT alone condition. These data suggest that for dually diagnosed patients with more severe cannabis use, ICART may be more efficacious than a gold-standard psychosocial CUD treatment, MET-CBT. MET-CBT may be more efficacious for those with less baseline cannabis use. (PsycInfo Database Record (c) 2021 APA, all rights reserved)},
	journal = {Experimental and Clinical Psychopharmacology},
	author = {Buckner, Julia D. and Morris, Paige E. and Zvolensky, Michael J.},
	year = {2021},
	note = {Place: US
Publisher: American Psychological Association},
	keywords = {Adult, Anxiety Disorders, Cannabis Use Disorder, Cognitive Behavior Therapy, Cognitive Behavioral Therapy, Comorbidity, Diagnosis, Dual (Psychiatry), Drug Usage, Dual Diagnosis, Female, Harm Reduction, Humans, Male, Marijuana, Marijuana Abuse, Severity of Illness Index, Treatment Outcome, Young Adult},
	pages = {No Pagination Specified--No Pagination Specified},
}

@article{cho_new_2021,
	title = {New {Data} on {Access} to {Mental} {Health} and {Addictions} {Services} and {Home} and {Community} {Care}},
	volume = {23},
	issn = {1710-2774},
	doi = {10.12927/hcq.2020.26400},
	abstract = {As the population ages, more Canadians need home care to help manage their health conditions and live safely at home. For Canadians of all ages, timely access to mental health and addictions services is an area of growing concern. The impact of the COVID-19 pandemic and its strain on health system resources have further highlighted the need to improve services in these areas. The Canadian Institute for Health Information (CIHI) is working with governments across Canada to bridge data gaps, develop indicators and publicly report results as part of a collective effort to improve access in these two sectors. Results for three new indicators were released by CIHI in 2020.},
	language = {eng},
	number = {4},
	journal = {Healthcare Quarterly (Toronto, Ont.)},
	author = {Cho, Maria Zaccaria and Frood, Jennifer and Husak, Liudmila and Lacroix, Jeanie and Hall, Norma and Turcotte, Luke Andrew},
	month = jan,
	year = {2021},
	pmid = {33475485},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Canada, Caregivers, Child, Community Health Services, Community Mental Health Services, Female, Health Services Accessibility, Home Care Services, Humans, Male, Mental Health Services, Middle Aged, Substance Abuse Treatment Centers, Substance-Related Disorders, Suicide, Young Adult},
	pages = {9--11},
}

@article{hildebrandt_randomized_2020,
	title = {Randomized {Controlled} {Trial} {Comparing} {Health} {Coach}-{Delivered} {Smartphone}-{Guided} {Self}-{Help} {With} {Standard} {Care} for {Adults} {With} {Binge} {Eating}.},
	volume = {177},
	issn = {1535-7228 0002-953X},
	doi = {10/ghsrqp},
	abstract = {OBJECTIVE: Cognitive-behavioral therapy (CBT) has shown efficacy in the treatment of eating disorders. The authors conducted a randomized controlled telemedicine trial  of CBT-guided self-help (CBT-GSH) assisted with a smartphone app, Noom Monitor, for  binge eating with or without purging. They hypothesized that coach-delivered CBT-GSH  telemedicine sessions plus Noom Monitor would yield greater reductions in symptoms  of binge eating, purging, and eating disorders compared with standard care. METHODS:  Fifty-two-week outcomes for CBT-GSH plus Noom Monitor (N=114) were compared with  outcomes for standard care (N=111) among members of an integrated health care system  in the Pacific Northwest. Patients in the health system who met inclusion criteria  were ≥18 years old, had a body mass index ≥18.5, met criteria for DSM-5 binge eating  disorder or bulimia nervosa, had 12 months of continuous health care enrollment in  Kaiser Permanente Northwest, and had a personal smartphone. Participants received  eight CBT-GSH telemedicine sessions over 12 weeks administered by health coaches,  and outcomes were assessed at baseline and at weeks 4, 8, 12, 26, and 52. The use of  available treatment offered within the Kaiser Permanente health care system was  permitted for participants assigned to standard care. RESULTS: Participants who  received CBT-GSH plus Noom Monitor reported significant reductions in objective  binge-eating days (β=-0.66, 95\% CI=-1.06, -0.25; Cohen's d=-1.46, 95\% CI=-4.63,  -1.09) and achieved higher rates of remission (56.7\% compared with 30\%; number  needed to treat=3.74) at 52 weeks compared with participants in standard care, none  of whom received any eating disorder treatment during the intervention period  (baseline and weeks 1-12). Similar patterns emerged for compensatory behaviors  (vomiting, use of laxatives, and excessive exercise; 76.3\% compared with 56.8\%;  number needed to treat=5.11), eating disorder symptoms (body shape, weight, eating  concerns, and dietary restraint), and clinical impairment (Cohen's d=-10.07, -2.15).  CONCLUSIONS: These results suggest that CBT-GSH plus Noom Monitor delivered via  telemedicine by routine-practice health coaches in a nonacademic health care system  yields reductions in symptoms and impairment over 52 weeks compared with standard  care.},
	language = {eng},
	number = {2},
	journal = {The American journal of psychiatry},
	author = {Hildebrandt, Tom and Michaeledes, Andreas and Mayhew, Meghan and Greif, Rebecca and Sysko, Robyn and Toro-Ramos, Tatiana and DeBar, Lynn},
	month = feb,
	year = {2020},
	pmid = {32008396},
	note = {Place: United States},
	keywords = {*Cognitive, *Cognitive Behavioral Therapy, *Computers, *Eating Disorders, *Gender Differences, *Metabolism, *Obsessive-Compulsive Disorder, *Smartphone, Adolescent, Adult, Binge-Eating Disorder/*therapy, Female, Humans, Male, Mentoring, Middle Aged, Telemedicine/*methods, Young Adult},
	pages = {134--142},
}

@article{burt_marijuana_2020,
	title = {Marijuana use and coronary artery disease in young adults},
	volume = {15},
	issn = {1932-6203 (Electronic) 1932-6203 (Linking)},
	doi = {10.1371/journal.pone.0228326},
	abstract = {BACKGROUND: Marijuana is the most popular drug of abuse in the United States. The association between its use and coronary artery disease has not yet been fully elucidated. This study aims to determine the frequency of coronary artery disease among young to middle aged adults presenting with chest pain who currently use marijuana as compared to nonusers. METHODS: In this retrospective study, 1,420 patients with chest pain or angina equivalent were studied. Only men between 18 and 40 years and women between 18 and 50 years of age without history of cardiac disease were included. All patients were queried about current or prior cannabis use and underwent coronary CT angiography. Each coronary artery on coronary CT angiography was assessed based on the CAD-RADS reporting system. RESULTS: A total of 146 (10.3\%) out of 1,420 patients with chest pain were identified as marijuana users. Only 6.8\% of the 146 marijuana users had evidence of coronary artery disease on coronary CT angiography. In comparison, the rate was 15.0\% among the 1,274 marijuana nonusers (p = 0.008). After accounting for other cardiac risk factors in a multivariate analysis, the negative association between marijuana use and coronary artery disease on coronary CT angiography diminished (p = 0.12, 95\% CI 0.299-1.15). A majority of marijuana users were younger than nonusers and had a lower frequency of hypertension and diabetes than nonusers. There was no statistical difference in lipid panel values between the two groups. Only 2 out of 10 marijuana users with coronary artery disease on coronary CT angiography had hemodynamically significant stenosis. CONCLUSION: Among younger patients being evaluated for chest pain, self-reported cannabis use conferred no additional risk of coronary artery disease as detected on coronary CT angiography.},
	number = {1},
	journal = {PLoS One},
	author = {Burt, J. R. and Agha, A. M. and Yacoub, B. and Zahergivar, A. and Pepe, J.},
	year = {2020},
	pmcid = {PMC6988970},
	keywords = {Adult, Case-Control Studies, Computed Tomography Angiography, Coronary Artery Disease/diagnostic imaging/*epidemiology, Female, Humans, Male, Marijuana Use/adverse effects/*epidemiology, Middle Aged, Retrospective Studies, United States/epidemiology, Young Adult},
	pages = {e0228326},
}

Paper  doi  bibtex   

@article{brakoulias_rates_2020,
	title = {The rates of co-occurring behavioural addictions in treatment-seeking individuals with obsessive-compulsive disorder: a preliminary report},
	volume = {24},
	issn = {13651501},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078016820&doi=10.1080%2f13651501.2019.1711424&partnerID=40&md5=f7662be6edcfacc238a638b465092af8},
	doi = {10.1080/13651501.2019.1711424},
	language = {English},
	number = {2},
	journal = {International Journal of Psychiatry in Clinical Practice},
	author = {Brakoulias, V. and Starcevic, V. and Albert, U. and Arumugham, S.S. and Bailey, B.E. and Belloch, A. and Borda, T. and Dell’Osso, L. and Elias, J.A. and Falkenstein, M.J. and Ferrao, Y.A. and Fontenelle, L.F. and Jelinek, L. and Kay, B. and Lochner, C. and Maina, G. and Marazziti, D. and Matsunaga, H. and Miguel, E.C. and Morgado, P. and Pasquini, M. and Perez-Rivera, R. and Potluri, S. and Reddy, J.Y.C. and Riemann, B.C. and do Rosario, M.C. and Shavitt, R.G. and Stein, D.J. and Viswasam, K. and Fineberg, N.A.},
	year = {2020},
	note = {Publisher: Taylor and Francis Ltd},
	keywords = {Addictive, Adolescent, Adult, Argentina, Article, Australia, Behavior, Brazil, Comorbidity, Female, Gambling, Germany, Humans, India, Internet, Internet Addiction Disorder, Italy, Japan, Male, Mexico, Middle Aged, Obsessive-Compulsive Disorder, Portugal, Sexual Behavior, South Africa, Spain, United Kingdom, United States, Video Games, Young Adult, addiction, adolescent, adult, behavioral addiction, clinical trial, comorbidity, compulsive buying, female, gambling, game addiction, help seeking behavior, human, internet addiction, major clinical study, male, middle aged, multicenter study, obsessive compulsive disorder, pathological gambling, priority journal, sexual behavior, video game, young adult},
	pages = {173--175},
}

Paper  doi  bibtex   

@article{lourens_acute_2020,
	title = {Acute pain assessment and management in the prehospital setting, in the {Western} {Cape}, {South} {Africa}: {A} knowledge, attitudes and practices survey},
	volume = {20},
	issn = {1471227X},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084107654&doi=10.1186%2fs12873-020-00315-0&partnerID=40&md5=6a9e1ed0ddf7e6a805a5a2f423b829e2},
	doi = {10.1186/s12873-020-00315-0},
	language = {English},
	number = {1},
	journal = {BMC Emergency Medicine},
	author = {Lourens, A. and Hodkinson, P. and Parker, R.},
	year = {2020},
	note = {Publisher: BioMed Central Ltd.},
	keywords = {Acute Pain, Adult, Article, Attitudes, Cross-Sectional Studies, Emergency Medical Technicians, Female, Health Knowledge, Humans, Internet, Male, Pain Measurement, Practice, Professional Competence, South Africa, Surveys and Questionnaires, adult, age, alcohol consumption, analgesia, analgesic agent, attitude, attitude to health, case study, clinical practice, controlled study, cross-sectional study, descriptive research, drug dependence, emergency care, female, gender, government, health personnel attitude, human, job experience, ketamine, male, medical education, middle aged, morphine, nitrous oxide plus oxygen, pain, pain assessment, pain measurement, patient-reported outcome, professional competence, questionnaire, rescue personnel, scoring system, validation study, young adult},
}

@article{correia_accelerated_2020,
	title = {Accelerated high-resolution free-breathing {3D} whole-heart {T2}-prepared black-blood and bright-blood cardiovascular magnetic resonance},
	volume = {22},
	issn = {1532-429X},
	doi = {10.1186/s12968-020-00691-3},
	abstract = {BACKGROUND: The free-breathing 3D whole-heart T2-prepared Bright-blood and black-blOOd phase SensiTive inversion recovery (BOOST) cardiovascular magnetic resonance (CMR) sequence was recently proposed for simultaneous bright-blood coronary CMR angiography and black-blood late gadolinium enhancement (LGE) imaging. This sequence enables simultaneous visualization of cardiac anatomy, coronary arteries and fibrosis. However, high-resolution ({\textless} 1.4 × 1.4 × 1.4 mm3) fully-sampled BOOST requires long acquisition times of {\textasciitilde} 20 min.
METHODS: In this work, we propose to extend a highly efficient respiratory-resolved motion-corrected reconstruction framework (XD-ORCCA) to T2-prepared BOOST to enable high-resolution 3D whole-heart coronary CMR angiography and black-blood LGE in a clinically feasible scan time. Twelve healthy subjects were imaged without contrast injection (pre-contrast BOOST) and 10 patients with suspected cardiovascular disease were imaged after contrast injection (post-contrast BOOST). A quantitative analysis software was used to compare accelerated pre-contrast BOOST against the fully-sampled counterpart (vessel sharpness and length of the left and right coronary arteries). Moreover, three cardiologists performed diagnostic image quality scoring for clinical 2D LGE and both bright- and black-blood 3D BOOST imaging using a 4-point scale (1-4, non-diagnostic-fully diagnostic). A two one-sided test of equivalence (TOST) was performed to compare the pre-contrast BOOST images. Nonparametric TOST was performed to compare post-contrast BOOST image quality scores.
RESULTS: The proposed method produces images from 3.8 × accelerated non-contrast-enhanced BOOST acquisitions with comparable vessel length and sharpness to those obtained from fully- sampled scans in healthy subjects. Moreover, in terms of visual grading, the 3D BOOST LGE datasets (median 4) and the clinical 2D counterpart (median 3.5) were found to be statistically equivalent (p {\textless} 0.05). In addition, bright-blood BOOST images allowed for visualization of the proximal and middle left anterior descending and right coronary sections with high diagnostic quality (mean score {\textgreater} 3.5).
CONCLUSIONS: The proposed framework provides high-resolution 3D whole-heart BOOST images from a single free-breathing acquisition in {\textasciitilde} 7 min.},
	language = {eng},
	number = {1},
	journal = {Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance},
	author = {Correia, Teresa and Ginami, Giulia and Rashid, Imran and Nordio, Giovanna and Hajhosseiny, Reza and Ismail, Tevfik F. and Neji, Radhouene and Botnar, René M. and Prieto, Claudia},
	month = dec,
	year = {2020},
	pmid = {33317570},
	pmcid = {PMC7737390},
	keywords = {Adult, Aged, Aged, 80 and over, Black-blood, Case-Control Studies, Compressed sensing, Contrast Media, Coronary Vessels, Coronary magnetic resonance angiography (CMRA), Female, Fibrosis, Heart Diseases, Humans, Image navigator, Imaging, Three-Dimensional, Late gadolinium enhancement (LGE), Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Predictive Value of Tests, Reproducibility of Results, Respiratory motion compensation, Workflow, Young Adult},
	pages = {88},
}

@article{chai_shedding_2019,
	title = {Shedding more light on the use of mechanical aortic valve replacement in patients with congenital heart disease},
	volume = {157},
	issn = {1097-685X},
	doi = {10.1016/j.jtcvs.2018.08.047},
	language = {eng},
	number = {1},
	journal = {The Journal of Thoracic and Cardiovascular Surgery},
	author = {Chai, Paul J.},
	year = {2019},
	pmid = {30266394},
	keywords = {Aortic Valve, Child, Heart Defects, Congenital, Heart Valve Prosthesis, Humans, Young Adult},
	pages = {341}
}

Paper  doi  abstract   bibtex   

@article{costa_impact_2019,
	title = {The impact of intimate partner violence on forgone healthcare: a population-based, multicentre {European} study},
	volume = {29},
	issn = {1464-360X},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30169658},
	doi = {10.1093/eurpub/cky167},
	abstract = {BACKGROUND: To examine the relationship between forgone healthcare and involvement in intimate partner violence (IPV) as victims, perpetrators or both. METHODS: This cross-sectional multicentre study assessed community non-institutionalized residents (n = 3496, aged 18-64) randomly selected from six European cities: Athens, Budapest, London, Östersund, Porto, Stuttgart. A common questionnaire was used, including self-reports of IPV and forgone healthcare ('Have you been in need of a certain care service in the past year, but did not seek any help?'). Odds ratios (ORs), 95\% confidence intervals (CIs) were computed fitting logistic regression models adjusted for city, chronic disease, self-assessed health status and financial strain. RESULTS: Participants experiencing past year IPV (vs. no violence) reported more often to forgone healthcare (n = 3279, 18.6\% vs. 15.3\%, P = 0.016). IPV experienced as both a victim and perpetrator was associated with forgone healthcare (adjusted OR, 95\%CI: 1.32, 1.02-1.70). CONCLUSION: IPV was associated with forgone healthcare, particularly for those experiencing violence as both victims and perpetrators. Results suggest that preventing IPV among adults may improve timely healthcare uptake.},
	language = {eng},
	number = {2},
	journal = {European journal of public health},
	author = {Costa, Diogo and Hatzidimitriadou, Eleni and Ioannidi-Kapolo, Elli and Lindert, Jutta and Soares, Joaquim and Sundin, Örjan and Toth, Olga and Barros, Henrique},
	month = apr,
	year = {2019},
	keywords = {Adolescent, Adult, Cross-Sectional Studies, Europe, Female, Health Status, Humans, Intimate Partner Violence/*statistics \& numerical data, Male, Middle Aged, Patient Acceptance of Health Care/*statistics \& numerical data, Socioeconomic Factors, Spouse Abuse/statistics \& numerical data, Young Adult},
	pages = {359--364},
}

Paper  doi  abstract   bibtex   

@article{barbour_d_l_online_2019,
	title = {Online {Machine} {Learning} {Audiometry}},
	volume = {40},
	issn = {1538-4667},
	url = {https://journals.lww.com/ear-hearing/Abstract/2019/07000/Online_Machine_Learning_Audiometry.14.aspx},
	doi = {10.1097/AUD.0000000000000669},
	abstract = {OBJECTIVES: A confluence of recent developments in cloud computing, real-time web audio and machine learning psychometric function estimation has made wide dissemination of sophisticated turn-key audiometric assessments possible. The authors have combined these capabilities into an online (i.e., web-based) pure-tone audiogram estimator intended to empower researchers and clinicians with advanced hearing tests without the need for custom programming or special hardware. The objective of this study was to assess the accuracy and reliability of this new online machine learning audiogram method relative to a commonly used hearing threshold estimation technique also implemented online for the first time in the same platform.
DESIGN: The authors performed air conduction pure-tone audiometry on 21 participants between the ages of 19 and 79 years (mean 41, SD 21) exhibiting a wide range of hearing abilities. For each ear, two repetitions of online machine learning audiogram estimation and two repetitions of online modified Hughson-Westlake ascending-descending audiogram estimation were acquired by an audiologist using the online software tools. The estimated hearing thresholds of these two techniques were compared at standard audiogram frequencies (i.e., 0.25, 0.5, 1, 2, 4, 8 kHz).
RESULTS: The two threshold estimation methods delivered very similar threshold estimates at standard audiogram frequencies. Specifically, the mean absolute difference between threshold estimates was 3.24 ± 5.15 dB. The mean absolute differences between repeated measurements of the online machine learning procedure and between repeated measurements of the Hughson-Westlake procedure were 2.85 ± 6.57 dB and 1.88 ± 3.56 dB, respectively. The machine learning method generated estimates of both threshold and spread (i.e., the inverse of psychometric slope) continuously across the entire frequency range tested from fewer samples on average than the modified Hughson-Westlake procedure required to estimate six discrete thresholds.
CONCLUSIONS: Online machine learning audiogram estimation in its current form provides all the information of conventional threshold audiometry with similar accuracy and reliability in less time. More importantly, however, this method provides additional audiogram details not provided by other methods. This standardized platform can be readily extended to bone conduction, masking, spectrotemporal modulation, speech perception, etc., unifying audiometric testing into a single comprehensive procedure efficient enough to become part of the standard audiologic workup.},
	language = {eng},
	number = {4},
	journal = {Ear and Hearing},
	author = {{Barbour, D. L.} and Howard, Rebecca T. and Song, Xinyu D. and Metzger, Nikki and Sukesan, Kiron A. and DiLorenzo, James C. and Snyder, Braham R. D. and Chen, Jeff Y. and Degen, Eleanor A. and Buchbinder, Jenna M. and Heisey, Katherine L.},
	month = aug,
	year = {2019},
	pmid = {30358656},
	pmcid = {PMC6476703},
	keywords = {Adult, Aged, Audiometry, Pure-Tone, Female, Hearing Loss, Humans, Internet, Machine Learning, Male, Middle Aged, Reproducibility of Results, Severity of Illness Index, Young Adult},
	pages = {918--926},
}

@article{compton_cannabis_2019,
	title = {Cannabis use disorders among adults in the {United} {States} during a time of increasing use of cannabis},
	volume = {204},
	issn = {1879-0046 (Electronic) 0376-8716 (Print) 0376-8716 (Linking)},
	doi = {10.1016/j.drugalcdep.2019.05.008},
	abstract = {BACKGROUND: Using U.S. National Surveys on Drug Use and Health (NSDUH) data, researchers found that prevalence of cannabis use among adults increased in recent years, but prevalence of DSM-IV cannabis use disorder (CUD) was stable. Examining trends of all individual CUD criteria and of CUD severity may elucidate reasons for the lack of increases in CUD. METHODS: Data were from 749,500 persons aged 18 or older who participated in the 2002-2017 NSDUH. Descriptive analyses and logistic regressions were applied. RESULTS: Among adults during 2002-2017, past-year prevalence of DSM-IV CUD remained stable at 1.5\% to 1.4\%, but cannabis use increased from 10.4\% to 15.3\%, daily/near daily use increased from 1.9\% to 4.2\%, and mild DSM-5 CUD increased from 1.4\% to 1.9\%. Among adult cannabis users, past-year prevalence of DSM-IV CUD decreased from 14.8\% to 9.3\%, daily/near daily use increased from 18.0\% to 27.2\%, and DSM-5 moderate (4-5 criteria) and severe (6+ criteria) CUD decreased from 4.3\% to 3.1\% and from 2.4\% to 1.3\%, respectively. Examining trends in individual CUD criteria during 2002-2017 among adults overall revealed increases in two criteria (tolerance; spending a lot of time getting/using cannabis or getting over cannabis effects) and decreases/no changes in other criteria; among adult cannabis users, there was no change in one criterion (tolerance) and decreases in other criteria. CONCLUSIONS: DSM-5's single dimension CUD measure may be more sensitive to diagnosis prevalence changes than the separate DSM-IV cannabis dependence and abuse categories. Future diagnostic approaches to assessing CUD may benefit from quantitatively oriented criteria.},
	journal = {Drug Alcohol Depend},
	author = {Compton, W. M. and Han, B. and Jones, C. M. and Blanco, C.},
	month = nov,
	year = {2019},
	pmcid = {PMC7028308},
	keywords = {Adolescent, Adult, Aged, Cannabis use, Cannabis use disorder, Diagnostic and Statistical Manual of Mental Disorders, Diagnostic criteria for cannabis use disorder, Dsm-5, Dsm-iv, Female, Health Surveys/methods/*trends, Humans, Male, Marijuana Abuse/diagnosis/*epidemiology/psychology, Marijuana Smoking/*epidemiology/psychology/*trends, Middle Aged, United States/epidemiology, Young Adult},
	pages = {107468},
}

@article{delling_does_2019,
	title = {Does cannabis legalisation change healthcare utilisation? {A} population-based study using the healthcare cost and utilisation project in {Colorado}, {USA}},
	volume = {9},
	issn = {2044-6055 (Electronic) 2044-6055 (Linking)},
	doi = {10.1136/bmjopen-2018-027432},
	abstract = {OBJECTIVE: To assess the effect of cannabis legalisation on health effects and healthcare utilisation in Colorado (CO), the first state to legalise recreational cannabis, when compared with two control states, New York (NY) and Oklahoma (OK). DESIGN: We used the 2010 to 2014 Healthcare Cost and Utilisation Project (HCUP) inpatient databases to compare changes in rates of healthcare utilisation and diagnoses in CO versus NY and OK. SETTING: Population-based, inpatient. PARTICIPANTS: HCUP state-wide data comprising over 28 million individuals and over 16 million hospitalisations across three states. MAIN OUTCOME MEASURES: We used International Classification of Diseases-Ninth Edition codes to assess changes in healthcare utilisation specific to various medical diagnoses potentially treated by or exacerbated by cannabis. Diagnoses were classified based on weight of evidence from the National Academy of Science (NAS). Negative binomial models were used to compare rates of admissions between states. RESULTS: In CO compared with NY and OK, respectively, cannabis abuse hospitalisations increased (risk ratio (RR) 1.27, 95\% CI 1.26 to 1.28 and RR 1.16, 95\% CI 1.15 to 1.17; both p{\textless}0.0005) post-legalisation. In CO, there was a reduction in total admissions but only when compared with OK (RR 0.97, 95\% CI 0.96 to 0.98, p{\textless}0.0005). Length of stay and costs did not change significantly in CO compared with NY or OK. Post-legalisation changes most consistent with NAS included an increase in motor vehicle accidents, alcohol abuse, overdose injury and a reduction in chronic pain admissions (all p{\textless}0.05 compared with each control state). CONCLUSIONS: Recreational cannabis legalisation is associated with neutral effects on healthcare utilisation. In line with previous evidence, cannabis liberalisation is linked to an increase in motor vehicle accidents, alcohol abuse, overdose injuries and a decrease in chronic pain admissions. Such population-level effects may help guide future decisions regarding cannabis use, prescription and policy.},
	number = {5},
	journal = {BMJ Open},
	author = {Delling, F. N. and Vittinghoff, E. and Dewland, T. A. and Pletcher, M. J. and Olgin, J. E. and Nah, G. and Aschbacher, K. and Fang, C. D. and Lee, E. S. and Fan, S. M. and Kazi, D. S. and Marcus, G. M.},
	month = may,
	year = {2019},
	pmcid = {PMC6530411},
	keywords = {*Legislation, Drug, *cannabis legalization, *health policy, *healthcare utilization, Accidents, Traffic/statistics \& numerical data, Adult, Alcoholism/epidemiology, Colorado/epidemiology, Female, Health Care Costs, Hospitalization/statistics \& numerical data, Humans, Length of Stay, Marijuana Abuse/*epidemiology, Marijuana Use/*legislation \& jurisprudence, Middle Aged, Patient Acceptance of Health Care/*statistics \& numerical data, Young Adult},
	pages = {e027432},
}

@article{koelewijn_metabolic_2019,
	title = {Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study},
	volume = {14},
	copyright = {All rights reserved},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0222037},
	abstract = {This paper compares predictions of metabolic energy expenditure in gait using seven metabolic energy expenditure models to assess their correlation with experimental data. Ground reaction forces, marker data, and pulmonary gas exchange data were recorded for six walking trials at combinations of two speeds, 0.8 m/s and 1.3 m/s, and three inclines, -8\% (downhill), level, and 8\% (uphill). The metabolic cost, calculated with the metabolic energy models was compared to the metabolic cost from the pulmonary gas exchange rates. A repeated measures correlation showed that all models correlated well with experimental data, with correlations of at least 0.9. The model by Bhargava et al. (J Biomech, 2004: 81-88) and the model by Lichtwark and Wilson (J Exp Biol, 2005: 2831-3843) had the highest correlation, 0.95. The model by Margaria (Int Z Angew Physiol Einschl Arbeitsphysiol, 1968: 339-351) predicted the increase in metabolic cost following a change in dynamics best in absolute terms.},
	language = {eng},
	number = {9},
	journal = {PloS One},
	author = {Koelewijn, Anne D. and Heinrich, Dieter and van den Bogert, Antonie J.},
	year = {2019},
	pmid = {31532796},
	pmcid = {PMC6750598},
	keywords = {Biomechanical Phenomena, Gait, Humans, Adult, Algorithms, Energy Metabolism, Female, Healthy Volunteers, Male, Models, Biological, Young Adult},
	pages = {e0222037},
	file = {Full Text:C\:\\Users\\Ton\\Zotero\\storage\\6WGBU7TN\\Koelewijn et al. - 2019 - Metabolic cost calculations of gait using musculos.pdf:application/pdf},
}

Paper  doi  abstract   bibtex   

@article{gonzales_exit_2018,
	title = {{EXIT} (ex utero intrapartum treatment) in a growth restricted fetus with tracheal atresia.},
	volume = {105},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/29447823},
	doi = {10.1016/j.ijporl.2017.12.010},
	abstract = {Congenital high airway obstruction syndrome (CHAOS) encompasses a heterogeneous group of pathologies leading to poor lung development and difficulty oxygenating the newborn after delivery. While previously uniformly fatal, the ex utero intrapartum therapy (EXIT) procedure has provided a method to treat these patients and provide an airway to potentiate survival. We present a patient diagnosed prenatally with CHAOS secondary to tracheal atresia complicated by severe intra-uterine growth restriction (IUGR) who was successfully delivered via an EXIT procedure at 33-weeks. Multidisciplinary care and planning is paramount.},
	language = {eng},
	journal = {Int J Pediatr Otorhinolaryngol},
	author = {Gonzales, SK and Goudy, S and Prickett, K and Ellis, J},
	month = feb,
	year = {2018},
	keywords = {Young Adult},
	pages = {72--74}
}

Paper  doi  abstract   bibtex   

@article{hernandez-yumar_socioeconomic_2018,
	title = {Socioeconomic differences in body mass index in {Spain}: {An} intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy},
	volume = {13},
	issn = {19326203},
	url = {https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85058236747&doi=10.1371%2fjournal.pone.0208624&partnerID=40&md5=2fa97f6447bf5ab0ad6b334abe212bb1},
	doi = {10.1371/journal.pone.0208624},
	abstract = {Many studies have demonstrated the existence of simple, unidimensional socioeconomic gradients in body mass index (BMI). However, in the present paper we move beyond such traditional analyses by simultaneously considering multiple demographic and socioeconomic dimensions. Using the Spanish National Health Survey 2011–2012, we apply intersectionality theory and multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) to analyze 14,190 adults nested within 108 intersectional strata defined by combining categories of gender, age, income, educational achievement and living situation. We develop two multilevel models to obtain information on stratum-specific BMI averages and the degree of clustering of BMI within strata expressed by the intra-class correlation coefficient (ICC). The first model is a simple variance components analysis that provides a detailed mapping of the BMI disparities in the population and measures the accuracy of stratum membership to predict individual BMI. The second model includes the variables used to define the intersectional strata as a way to identify stratum-specific interactions. The first model suggests moderate but meaningful clustering of individual BMI within the intersectional strata (ICC = 12.4\%). Compared with the population average (BMI = 26.07 Kg/m2), the stratum of cohabiting 18-35-year-old females with medium income and high education presents the lowest BMI (-3.7 Kg/m2), while cohabiting 36-64-year-old females with low income and low education show the highest BMI (+2.6 Kg/m2). In the second model, the ICC falls to 1.9\%, suggesting the existence of only very small stratum specific interaction effects. We confirm the existence of a socioeconomic gradient in BMI. Compared with traditional analyses, the intersectional MAIHDA approach provides a better mapping of socioeconomic and demographic inequalities in BMI. Because of the moderate clustering, public health policies aiming to reduce BMI in Spain should not solely focus on the intersectional strata with the highest BMI, but should also consider whole population polices. © 2018 Hernández-Yumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
	language = {English},
	number = {12},
	journal = {PLoS ONE},
	author = {Hernández-Yumar, A. and Wemrell, M. and Alessón, I.A. and López-Valcárcel, B.G. and Leckie, G. and Merlo, J.},
	year = {2018},
	keywords = {Adolescent, Adult, Aged, Body Mass Index, Cluster Analysis, Cross-Sectional Studies, Educational Status, Family Characteristics, Female, Health Surveys, Humans, Income, Interviews as Topic, Male, Middle Aged, Spain, Young Adult, achievement, adolescent, adult, aged, article, body mass, cluster analysis, cohabiting person, controlled study, correlation coefficient, cross-sectional study, education, educational status, family size, female, gender, health survey, human, human experiment, income, interview, lowest income group, major clinical study, male, middle aged, multilevel analysis, police, public health, variance, young adult}
}

@article{grubbs_moral_2018,
	title = {Moral disapproval and perceived addiction to internet pornography: a longitudinal examination.},
	volume = {113},
	copyright = {(c) 2017 Society for the Study of Addiction.},
	issn = {1360-0443 0965-2140},
	doi = {10.1111/add.14007},
	abstract = {BACKGROUND AND AIMS: Internet pornography use is an increasingly common, yet controversial, behavior. Whereas mental health communities are divided about potentially problematic use patterns, many lay people identify as feeling dysregulated or compulsive in their use. Prior work has labeled this tendency perceived addiction to internet pornography (PA). This study's aims were to (1) assess the association between PA at baseline and other factors, including actual levels of average daily pornography use and personality factors and (2) assess the associations between baseline variables and PA 1 year later. DESIGN: Two large-scale community samples were assessed using online survey methods, with subsets of each sample being recruited for follow-up surveys 1 year later. SETTING: United States. PARTICIPANTS: Participants were adults who had used pornography within the past 6 months recruited in two samples. Sample 1 (n = 1507) involved undergraduate students from three US universities and sample 2 (n  = 782) involved web-using adults. Subsets of each sample (sample 1, n = 146; sample 2, n = 211) were surveyed again 1 year later. MEASUREMENTS: At baseline, we assessed average daily pornography use, PA and relevant predictors (e.g. trait neuroticism, trait self-control, trait entitlement, religiousness, moral disapproval of pornography use). One year later, we assessed PA. FINDINGS: Cross-sectionally, PA was correlated strongly with moral disapproval of pornography use [sample 1, Pearson's correlation: r = 0.68 (0.65, 0.70); sample 2, r = 0.58 (0.53, 0.63)]. Baseline moral disapproval [sample 1, r = 0.46 (0.33,  0.56); sample 2, r = 0.61 (0.51, 0.69)] and perceived addiction demonstrated relationships with perceived addiction 1 year later. We found inconclusive evidence of a substantial or significant association between pornography use and  perceived addiction over time [sample 1, r = 0.13 (-0.02, 0.28); sample 2, r = 0.11 (-0.04, 0.25)]. CONCLUSIONS: Perceived addiction to internet pornography appears to be related strongly to moral scruples around pornography use, both concurrently and over time, rather than with the amount of daily pornography use  itself.},
	language = {eng},
	number = {3},
	journal = {Addiction},
	author = {Grubbs, Joshua B. and Wilt, Joshua A. and Exline, Julie J. and Pargament, Kenneth I. and Kraus, Shane W.},
	month = apr,
	year = {2018},
	pmid = {28833800},
	keywords = {*Attitude to Health, *Compulsive sexual behavior, *Morals, *personality, *pornography, *religion, *self-perception, *sexuality, *Social Norms, Adult, Attitude to Health, Behavior, Addictive, Behavior, Addictive/*psychology, Compulsive sexual behavior, Control (Psychology), CONTROL (Psychology), Cross Sectional Studies, Cross-Sectional Studies, Descriptive Statistics, Erotica, Erotica/*psychology, ETHICS, Female, Follow-Up Studies, Human, Humans, Internet, INTERNET pornography addiction, Internet Pornography Addiction -- Classification, Longitudinal Studies, Male, Morality, Morals, Multicenter Studies, No terms assigned, Pearson's Correlation Coefficient, personality, Personality, PERSONALITY, pornography, Pornography, PORNOGRAPHY, PORNOGRAPHY -- Moral \& ethical aspects, Pornography -- Utilization, Prospective Studies, religion, Religion, self-perception, Self-Perception, self‐perception, Sexual Addiction, sexuality, Sexuality, Social Norms, Students, Students, Undergraduate, Students/psychology/statistics \& numerical data, Surveys and Questionnaires, United States, UNITED States, Universities, Young Adult},
	pages = {496--506},
	file = {Full Text PDF:/Users/joshuab.grubbs/Library/CloudStorage/GoogleDrive-joshuagrubbsphd@gmail.com/My Drive/Manuscripts/Zotero/storage/EIR8JK5B/Grubbs et al. - Moral disapproval and perceived addiction to inter.pdf:application/pdf;Full Text PDF:/Users/joshuab.grubbs/Library/CloudStorage/GoogleDrive-joshuagrubbsphd@gmail.com/My Drive/Manuscripts/Zotero/storage/MCJ7KH6W/Grubbs et al. - 2018 - Moral disapproval and perceived addiction to inter.pdf:application/pdf;Snapshot:/Users/joshuab.grubbs/Library/CloudStorage/GoogleDrive-joshuagrubbsphd@gmail.com/My Drive/Manuscripts/Zotero/storage/6SFFEZ33/abstract.html:text/html;Snapshot:/Users/joshuab.grubbs/Library/CloudStorage/GoogleDrive-joshuagrubbsphd@gmail.com/My Drive/Manuscripts/Zotero/storage/B2BPPKVL/abstract.html:text/html},
}

@article{devinsky_effect_2018,
	title = {Effect of {Cannabidiol} on {Drop} {Seizures} in the {Lennox}-{Gastaut} {Syndrome}},
	volume = {378},
	issn = {1533-4406 (Electronic) 0028-4793 (Linking)},
	doi = {10.1056/NEJMoa1714631},
	abstract = {BACKGROUND: Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy and safety of cannabidiol added to a regimen of conventional antiepileptic medication to treat drop seizures in patients with the Lennox-Gastaut syndrome, a severe developmental epileptic encephalopathy. METHODS: In this double-blind, placebo-controlled trial conducted at 30 clinical centers, we randomly assigned patients with the Lennox-Gastaut syndrome (age range, 2 to 55 years) who had had two or more drop seizures per week during a 28-day baseline period to receive cannabidiol oral solution at a dose of either 20 mg per kilogram of body weight (20-mg cannabidiol group) or 10 mg per kilogram (10-mg cannabidiol group) or matching placebo, administered in two equally divided doses daily for 14 weeks. The primary outcome was the percentage change from baseline in the frequency of drop seizures (average per 28 days) during the treatment period. RESULTS: A total of 225 patients were enrolled; 76 patients were assigned to the 20-mg cannabidiol group, 73 to the 10-mg cannabidiol group, and 76 to the placebo group. During the 28-day baseline period, the median number of drop seizures was 85 in all trial groups combined. The median percent reduction from baseline in drop-seizure frequency during the treatment period was 41.9\% in the 20-mg cannabidiol group, 37.2\% in the 10-mg cannabidiol group, and 17.2\% in the placebo group (P=0.005 for the 20-mg cannabidiol group vs. placebo group, and P=0.002 for the 10-mg cannabidiol group vs. placebo group). The most common adverse events among the patients in the cannabidiol groups were somnolence, decreased appetite, and diarrhea; these events occurred more frequently in the higher-dose group. Six patients in the 20-mg cannabidiol group and 1 patient in the 10-mg cannabidiol group discontinued the trial medication because of adverse events and were withdrawn from the trial. Fourteen patients who received cannabidiol (9\%) had elevated liver aminotransferase concentrations. CONCLUSIONS: Among children and adults with the Lennox-Gastaut syndrome, the addition of cannabidiol at a dose of 10 mg or 20 mg per kilogram per day to a conventional antiepileptic regimen resulted in greater reductions in the frequency of drop seizures than placebo. Adverse events with cannabidiol included elevated liver aminotransferase concentrations. (Funded by GW Pharmaceuticals; GWPCARE3 ClinicalTrials.gov number, NCT02224560 .).},
	number = {20},
	journal = {N Engl J Med},
	author = {Devinsky, O. and Patel, A. D. and Cross, J. H. and Villanueva, V. and Wirrell, E. C. and Privitera, M. and Greenwood, S. M. and Roberts, C. and Checketts, D. and VanLandingham, K. E. and Zuberi, S. M. and Gwpcare Study Group},
	month = may,
	year = {2018},
	keywords = {Adolescent, Adult, Anticonvulsants/*administration \& dosage/adverse effects/therapeutic use, Cannabidiol/*administration \& dosage/adverse effects, Child, Child, Preschool, Dose-Response Relationship, Drug, Double-Blind Method, Drug Therapy, Combination, Humans, Lennox Gastaut Syndrome/complications/*drug therapy, Male, Middle Aged, Odds Ratio, Seizures/*prevention \& control, Transaminases/blood, Young Adult},
	pages = {1888--1897},
}

Paper  abstract   bibtex   

@misc{baker_s.c._systematic_2017,
	title = {Systematic {Review} of {Interventions} to {Reduce} {Psychiatric} {Morbidity} in {Parents} and {Children} {After} {PICU} {Admissions}},
	url = {http://journals.lww.com/pccmjournal},
	abstract = {OBJECTIVE:: To describe and evaluate interventions aimed at reducing psychiatric morbidity in parents and children discharged from PICU. DATA SOURCES:: A systematic review of the literature was undertaken, searching EMBASE, PSYCHinfo, MEDLINE, and CINAHL. Experts in the field were contacted to identify unpublished studies. STUDY SELECTION:: Exclusion criteria: Studies with participants above age 18 or drawn from a neonatal ICU, studies not in English, and those not measuring psychopathology. DATA EXTRACTION:: Seven hundred fifty-three articles initially identified were hand searched which identified three studies, with a further three studies found by contacting experts in the field. Of these, three were randomized controlled trials and three feasibility studies. DATA SYNTHESIS:: The interventions primarily targeted parents (particularly mothers), with the aim of reducing psychopathology especially posttraumatic stress disorder. Findings from these few studies demonstrated that interventions can lead to a reduction in parent and child psychopathology. Key ingredients of these interventions included psychoeducation, parent support after discharge, offering intervention to those families at high risk of developing psychopathology as identified by screening at the point of discharge, follow-up of all families with the aim of case finding, and specific interventions to target posttraumatic stress disorder symptoms. CONCLUSIONS:: Intervention studies are few but do lead to reductions in parent and child psychopathology. There is sufficient information to suggest some of these interventions could be supported and further evaluated. Copyright ©2017The Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies},
	journal = {Pediatric Critical Care Medicine},
	author = {{Baker S.C.} and {Gledhill J.A.}},
	year = {2017},
	keywords = {*morbidity, *psychiatric intensive care unit, Child, Cinahl, Embase, Medline, Neonatal intensive care unit, PsycINFO, adult, case finding, controlled study, family study, feasibility study, female, follow up, human, intervention study, mental disease, mother, newborn, posttraumatic stress disorder, psychoeducation, screening, systematic review, young adult}
}

Paper  abstract   bibtex   

@article{correa-selm_use_2017,
	title = {Use of {Biologics} in {Private} {Practice}: {Nine} {Years} of {Lessons} and {Learning}},
	volume = {16},
	copyright = {All rights reserved},
	issn = {1545-9616 (Print) 1545-9616 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/28301616},
	abstract = {{\textless}p{\textgreater}Over a decade ago, the FDA approved biologics for psoriasis, which changed how the disease is treated and, in most cases, has a significant positive impact on the lives of patients. Side effects primarily identified during the investigational and research phase led to the development of specific guidelines for treatment. The treatment guidelines have been amended to incorporate better understandings of side-effects over the years that the disease has been treated. In this study, we focused on a chart review that included assessing the current guidelines and their alignment with modern patient management and the recent side effects presented. This life-cycle evaluation included over 100 patients, management of their treatment, laboratory abnormalities, criteria for choosing or changing to a different biologic, and the effects of the treatments management throughout the years. The review identified some recommended changes in the application and treatment of psoriasis with biologics. To further evidence our findings, we hope to expand this study to a larger scale with more patients.{\textless}/p{\textgreater} {\textless}p{\textgreater}{\textless}em{\textgreater}J Drugs Dermatol. 2017;16(3):215-217.{\textless}/em{\textgreater}{\textless}/p{\textgreater}.},
	number = {3},
	journal = {J Drugs Dermatol},
	author = {Correa-Selm, L. M. and Alamgir, M. and Rao, B. K.},
	month = mar,
	year = {2017},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Biological Products/administration \& dosage/adverse effects/*therapeutic use, Child, Female, Humans, Male, Middle Aged, Practice Guidelines as Topic, Private Practice/*trends, Psoriasis/blood/*drug therapy, Quality of Life, Retrospective Studies, Severity of Illness Index, Young Adult},
	pages = {215--217},
}

@article{engels_cancer-attributable_2017,
	title = {Cancer-{Attributable} {Mortality} {Among} {People} {With} {Treated} {Human} {Immunodeficiency} {Virus} {Infection} in {North} {America}},
	volume = {65},
	issn = {1537-6591},
	doi = {10.1093/cid/cix392},
	abstract = {Background: Cancer remains an important cause of morbidity and mortality in people with human immunodeficiency virus (PWHIV) on effective antiretroviral therapy (ART). Estimates of cancer-attributable mortality can inform public health efforts.
Methods: We evaluated 46956 PWHIV receiving ART in North American HIV cohorts (1995-2009). Using information on incident cancers and deaths, we calculated population-attributable fractions (PAFs), estimating the proportion of deaths due to cancer. Calculations were based on proportional hazards models adjusted for age, sex, race, HIV risk group, calendar year, cohort, CD4 count, and viral load.
Results: There were 1997 incident cancers and 8956 deaths during 267145 person-years of follow-up, and 11.9\% of decedents had a prior cancer. An estimated 9.8\% of deaths were attributable to cancer (cancer-attributable mortality rate 327 per 100000 person-years). PAFs were 2.6\% for AIDS-defining cancers (ADCs, including non-Hodgkin lymphoma, 2.0\% of deaths) and 7.1\% for non-AIDS-defining cancers (NADCs: lung cancer, 2.3\%; liver cancer, 0.9\%). PAFs for NADCs were higher in males and increased strongly with age, reaching 12.5\% in PWHIV aged 55+ years. Mortality rates attributable to ADCs and NADCs were highest for PWHIV with CD4 counts {\textless}100 cells/mm3. PAFs for NADCs increased during 1995-2009, reaching 10.1\% in 2006-2009.
Conclusions: Approximately 10\% of deaths in PWHIV prescribed ART during 1995-2009 were attributable to cancer, but this fraction increased over time. A large proportion of cancer-attributable deaths were associated with non-Hodgkin lymphoma, lung cancer, and liver cancer. Deaths due to NADCs will likely grow in importance as AIDS mortality declines and PWHIV age.},
	language = {eng},
	number = {4},
	journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
	author = {Engels, Eric A. and Yanik, Elizabeth L. and Wheeler, Willian and Gill, M. John and Shiels, Meredith S. and Dubrow, Robert and Althoff, Keri N. and Silverberg, Michael J. and Brooks, John T. and Kitahata, Mari M. and Goedert, James J. and Grover, Surbhi and Mayor, Angel M. and Moore, Richard D. and Park, Lesley S. and Rachlis, Anita and Sigel, Keith and Sterling, Timothy R. and Thorne, Jennifer E. and Pfeiffer, Ruth M. and {North American AIDS Cohort Collaboration on Research and
                    Design of the International Epidemiologic Databases to Evaluate AIDS} and {North American AIDS Cohort Collaboration on Research and Design
                    of the International Epidemiologic Databases to Evaluate AIDS}},
	month = aug,
	year = {2017},
	pmid = {29017269},
	pmcid = {PMC5849088},
	keywords = {AIDS, Adolescent, Adult, CD4 Lymphocyte Count, Female, HIV, HIV Infections, Humans, Male, Middle Aged, Neoplasms, North America, Proportional Hazards Models, Retrospective Studies, Viral Load, Young Adult, aging, cancer, mortality},
	pages = {636--643},
}

Paper  doi  bibtex   

@article{giordano_j_lung_2017,
title = {Lung perfusion characteristics in pulmonary arterial hypertension (PAH) and peripheral forms of chronic thromboembolic pulmonary hypertension (pCTEPH): Dual-energy CT experience in 31 patients},
volume = {27},
issn = {0938-7994},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27480438},
DOI = {10.1007/s00330-016-4500-6},
Language = {English},
Journal = {Eur. Radiol.},
author = {{Giordano J} and {Khung S} and {Duhamel A} and {Hossein-Foucher C} and {Bellèvre D} and {Lamblin N} and {Remy J} and {Remy-Jardin M}},
year = {2017},
keywords = {Adult, Aged, Aged, 80 and over, Angiography/methods, Chronic Disease, Diagnosis, Differential, Female, Humans, Hypertension, Pulmonary/diagnostic imaging*, Hypertension, Pulmonary/etiology, Male, Middle Aged, Perfusion Imaging/methods, Pulmonary Embolism/complications, Pulmonary Embolism/diagnostic imaging*, Tomography, X-Ray Computed/methods, Young Adult},
pages = {1631-1639}
}

@article{grillon_anxiety-mediated_2017,
	title = {Anxiety-mediated facilitation of behavioral inhibition: {Threat} processing and defensive reactivity during a go/no-go task.},
	volume = {17},
	copyright = {(c) 2017 APA, all rights reserved).},
	issn = {1931-1516 1528-3542},
	doi = {10.1037/emo0000214},
	abstract = {Anxiety can be broken down into multiple facets including behavioral components, such as defensive reactivity, and cognitive components, such as distracting  anxious thoughts. In a previous study, we showed that anticipation of  unpredictable shocks facilitated response inhibition to infrequent no-go trials  during a go/no-go task. The present study extends this work to examine the  distinct contribution of defensive reactivity, measures with fear-potentiated  startle, and anxious thought, assessed with thought probes, on go and no-go  performance. Consistent with our prior findings, shock anticipation facilitated  response inhibition (i.e., reduced errors of commission) on the no-go trials.  Regression analyses showed that (a) no-go accuracy was positively associated with  fear-potentiated startle and negatively associated with  threat-related/task-unrelated thoughts and (b) go accuracy correlated negatively  with fear-potentiated startle. Thus, while the present findings confirm the  influence of anxiety on response inhibition, they also show that such influence  reflects the balance between the positive effect of defensive reactivity and the  negative effect of distracting anxious thoughts. (PsycINFO Database Record},
	language = {eng},
	number = {2},
	journal = {Emotion (Washington, D.C.)},
	author = {Grillon, Christian and Robinson, Oliver J. and Krimsky, Marissa and O'Connell, Katherine and Alvarez, Gabriella and Ernst, Monique},
	month = mar,
	year = {2017},
	pmid = {27642657},
	pmcid = {PMC5328922},
	note = {Place: United States},
	keywords = {*Inhibition, *Inhibition, Psychological, Adult, Anxiety/*psychology, Fear/*psychology, Female, Humans, Male, Neuropsychological Tests, Psychological, Reflex, Reflex, Startle/*physiology, Startle/*physiology, Young Adult},
	pages = {259--266},
}

@article{failing_lymphocyte--monocyte_2017,
	title = {Lymphocyte-to-monocyte ratio is associated with survival in pembrolizumab-treated metastatic melanoma patients},
	volume = {27},
	issn = {1473-5636},
	doi = {10.1097/CMR.0000000000000404},
	abstract = {The peripheral blood lymphocyte-to-monocyte ratio (LMR) has been associated with prognosis in many malignancies including metastatic melanoma. However, it has not been studied in patients treated with immune checkpoint inhibitors. In this study, we analyzed the baseline LMR with progression-free survival (PFS) and overall survival (OS) in metastatic melanoma patients treated with pembrolizumab. A total of 133 patients with metastatic melanoma treated with pembrolizumab were included in this retrospective study. LMR was calculated from pretherapy peripheral blood counts and the optimal cutoff value was determined by a receiver operator characteristic curve. PFS and OS were evaluated using the Kaplan-Meier method and multivariate Cox proportional hazard modeling. Patients with an LMR of at least 1.7 showed improved PFS (hazard ratio=0.55; 95\% confidence interval: 0.34-0.92; P=0.024) and OS (hazard ratio=0.29; 95\% confidence interval: 0.15-0.59; P=0.0007). The baseline LMR is associated with PFS and OS in metastatic melanoma patients treated with pembrolizumab, and could represent a convenient and cost-effective prognostic biomarker. Validation of these findings in an independent cohort is needed.},
	language = {eng},
	number = {6},
	journal = {Melanoma Research},
	author = {Failing, Jarrett J. and Yan, Yiyi and Porrata, Luis F. and Markovic, Svetomir N.},
	year = {2017},
	pmid = {29016387},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Female, Humans, Lymphocytes, Male, Melanoma, Middle Aged, Monocytes, Prognosis, Retrospective Studies, Young Adult},
	pages = {596--600},
}

Website  abstract   bibtex   

@article{
 title = {Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder},
 type = {article},
 year = {2017},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Brain,Female,Gray matter,Humans,Image Processing, Computer-Assisted,International Cooperation,Magnetic Resonance Imaging,Male,Mega-analysis,Phobia, Social,Psychiatric Status Rating Scales,Social anxiety disorder,Striatum,Structural MRI,Voxel-based morphometry,Young Adult},
 pages = {678-688},
 volume = {16},
 websites = {http://files/902/Bas-Hoogendam et al. - 2017 - Voxel-based morphometry multi-center mega-analysis.pdf,http://www.ncbi.nlm.nih.gov/pubmed/30140607},
 id = {c82cd7bf-8c95-328e-998c-0faeffeb94d5},
 created = {2020-09-17T09:27:56.053Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:56.053Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in gray matter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multi-site imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM volume were present in the other ROIs. Thereby, the results of this mega-analysis suggest a role for the dorsal striatum in SAD, but previously reported SAD-related changes in GM in the amygdala, hippocampus, precuneus, prefrontal cortex and parietal regions were not replicated. Our findings emphasize the importance of large sample imaging studies and the need for meta-analyses like those performed by the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium.},
 bibtype = {article},
 author = {Bas-Hoogendam, Janna Marie and van Steenbergen, Henk and Nienke Pannekoek, J and Fouche, Jean-Paul and Lochner, Christine and Hattingh, Coenraad J and Cremers, Henk R and Furmark, Tomas and Månsson, Kristoffer N T and Frick, Andreas and Engman, Jonas and Boraxbekk, Carl-Johan and Carlbring, Per and Andersson, Gerhard and Fredrikson, Mats and Straube, Thomas and Peterburs, Jutta and Klumpp, Heide and Phan, K Luan and Roelofs, Karin and Veltman, Dick J and van Tol, Marie-José and Stein, Dan J and van der Wee, Nic J A},
 journal = {NeuroImage. Clinical}
}

@article{tang_online_2017,
	title = {Online social networking addiction among college students in {Singapore}: {Comorbidity} with behavioral addiction and affective disorder.},
	volume = {25},
	issn = {1876-2026},
	doi = {10.1016/j.ajp.2016.10.027},
	abstract = {PURPOSE OF THE RESEARCH: This study aimed to determine the prevalence of addiction to social networking sites/platforms (SNS) and its comorbidity with other behavioral addiction and affective disorder among college students in Singapore. 1110 college students (age: M=21.46, SD=1.80) in Singapore completed measures assessing online social networking, unhealthy food intake and shopping addiction as well as depression, anxiety and mania. Descriptive analyses were conducted to investigate the prevalence and comorbidity of behavioral addiction and affective disorder. Chi-square tests were used to examine gender differences., THE PRINCIPAL RESULTS: The prevalence rates of SNS, food and shopping addiction were 29.5\%, 4.7\% and 9.3\% respectively for the total sample. SNS addiction was found to co-occur with food addiction (3\%), shopping addiction (5\%), and both food and shopping addiction (1\%). The comorbidity rates of SNS addiction and affective disorder were 21\% for depression, 27.7\% for anxiety, and 26.1\% for mania. Compared with the total sample, students with SNS addiction reported higher comorbidity rates with other behavioral addiction and affective disorder. In general, females as compared to males reported higher comorbidity rates of SNS addiction and affective disorder., MAJOR CONCLUSIONS: SNS addiction has a high prevalence rate among college students in Singapore. Students with SNS addiction were vulnerable to experience other behavior addiction as well as affective disorder, especially among females. Copyright © 2016. Published by Elsevier B.V.},
	number = {101517820},
	journal = {Asian journal of psychiatry},
	author = {Tang, Catherine So-Kum and Koh, Yvaine Yee Woen},
	year = {2017},
	note = {Tang, Catherine So-Kum. The National University of Singapore, Department of Psychology, 9 Arts Link, The National University of Singapore, 117570, Singapore. Electronic address: tang.catherine@nus.edu.sg.
Koh, Yvaine Yee Woen. The National University of Singapore, AS8 \#07-56, 10 Kent Ridge Crescent (S) 119260, Kent Ridge Campus, Singapore. Electronic address: arikyw@nus.edu.sg.},
	keywords = {*Behavior, Addictive/ep [Epidemiology], *Mood Disorders/ep [Epidemiology], *Social Media/sn [Statistics \& Numerical Data], *Social Networking, *Students/sn [Statistics \& Numerical Data], Adolescent, Adult, Comorbidity, Female, Humans, Male, Prevalence, Singapore/ep [Epidemiology], Young Adult},
	pages = {175--178},
}

@article{kiadaliri_absolute_2016,
	title = {Absolute and relative educational inequalities in obesity among adults in {Tehran}: {Findings} from the {Urban} {HEART} {Study}-2.},
	volume = {10 Suppl 1},
	issn = {1871-403X},
	shorttitle = {Absolute and relative educational inequalities in obesity among adults in {Tehran}},
	doi = {10.1016/j.orcp.2015.05.002},
	abstract = {BACKGROUND: The prevalence of obesity is increasing in Iran. Previous studies showed mixed results in relation to association between socioeconomic status and obesity in the country. The current study aimed to examine educational inequalities among adults in Tehran in 2011.
METHOD: Data on 90,435 persons 18 years and older from Urban Health Equity Assessment and Response Tool (Urban HEART-2) were analyzed. The Slope Index of Inequality (SII) and the Relative Index of Inequality (RII) were used for assessing educational inequalities in obesity. These measures were quantified using generalized linear models for the binomial family adjusted for sex and age. Subgroup analysis was conducted across sex, age groups and the 22 districts of Tehran.
RESULTS: Both SII and RII showed substantial educational inequalities in obesity in favour of more educated adults [RII and SII (95\% CI were equal to 2.91 (2.71-3.11) and 0.12 (0.12-0.13)), respectively]. These educational inequalities were persistent even after adjusting for employment, marital status and smoking. Subgroup analysis revealed that educational inequalities were more profound among women. While among men educational inequalities were generally increasing with age, an inverse trend was observed among women. Educational inequalities were observed within all 22 districts of Tehran and generally there were no statistically significant differences between districts.
CONCLUSION: An inverse association between education and obesity was observed in the current study. To decrease educational inequalities in Tehran, priority should be given to younger women and older men. Further analyses are needed to explain these inequalities.},
	language = {eng},
	journal = {Obesity Research \& Clinical Practice},
	author = {Kiadaliri, Aliasghar A. and Asadi-Lari, Mohsen and Kalantari, Naser and Jafari, Mehdi and Vaez Mahdavi, Mohammad Reza and Faghihzadeh, Soghrat},
	month = sep,
	year = {2016},
	pmid = {26003304},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Educational Status, Educational inequality, Female, Generalized linear model, Humans, Iran, Male, Middle Aged, Obesity, Sex Factors, Social Class, Socioeconomic Factors, Urban-HEART, Young Adult},
	pages = {S57--S63},
}

Website  abstract   bibtex   

@article{
 title = {Problematic internet use (PIU): Associations with the impulsive-compulsive spectrum. An application of machine learning in psychiatry},
 type = {article},
 year = {2016},
 identifiers = {[object Object]},
 keywords = {ADHD,Adolescent,Adult,Aged,Aged, 80 and over,Behavior, Addictive,Compulsive Behavior,Compulsivity,Female,Humans,Impulsivity,Internet,Internet use,Machine Learning,Machine learning,Male,Middle Aged,OCD,Obsessive-Compulsive Disorder,Online Systems,Predictive Value of Tests,Psychiatry,ROC Curve,Reproducibility of Results,South Africa,Surveys and Questionnaires,United States,Young Adult},
 pages = {94-102},
 volume = {83},
 websites = {http://files/1161/Ioannidis et al. - 2016 - Problematic internet use (PIU) Associations with .pdf,http://www.ncbi.nlm.nih.gov/pubmed/27580487},
 id = {018be67c-9f6d-3317-bdff-f0e36f34becb},
 created = {2020-09-17T09:27:55.706Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:55.706Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {Problematic internet use is common, functionally impairing, and in need of further study. Its relationship with obsessive-compulsive and impulsive disorders is unclear. Our objective was to evaluate whether problematic internet use can be predicted from recognised forms of impulsive and compulsive traits and symptomatology. We recruited volunteers aged 18 and older using media advertisements at two sites (Chicago USA, and Stellenbosch, South Africa) to complete an extensive online survey. State-of-the-art out-of-sample evaluation of machine learning predictive models was used, which included Logistic Regression, Random Forests and Naïve Bayes. Problematic internet use was identified using the Internet Addiction Test (IAT). 2006 complete cases were analysed, of whom 181 (9.0%) had moderate/severe problematic internet use. Using Logistic Regression and Naïve Bayes we produced a classification prediction with a receiver operating characteristic area under the curve (ROC-AUC) of 0.83 (SD 0.03) whereas using a Random Forests algorithm the prediction ROC-AUC was 0.84 (SD 0.03) [all three models superior to baseline models p < 0.0001]. The models showed robust transfer between the study sites in all validation sets [p < 0.0001]. Prediction of problematic internet use was possible using specific measures of impulsivity and compulsivity in a population of volunteers. Moreover, this study offers proof-of-concept in support of using machine learning in psychiatry to demonstrate replicability of results across geographically and culturally distinct settings.},
 bibtype = {article},
 author = {Ioannidis, Konstantinos and Chamberlain, Samuel R and Treder, Matthias S and Kiraly, Franz and Leppink, Eric W and Redden, Sarah A and Stein, Dan J and Lochner, Christine and Grant, Jon E},
 journal = {Journal of Psychiatric Research}
}

Website  abstract   bibtex   

@article{
 title = {Prefrontal cortical thinning in HIV infection is associated with impaired striatal functioning},
 type = {article},
 year = {2016},
 identifiers = {[object Object]},
 keywords = {Adult,Anticipation, Psychological,Atrophy,Cortex,Female,HIV,HIV Infections,Humans,Inhibition,Inhibition, Psychological,Magnetic Resonance Imaging,Male,Neostriatum,Prefrontal Cortex,Striatum,Young Adult,fMRI},
 pages = {643-651},
 volume = {123},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/27173383},
 id = {d7fe6fe0-8a37-3c4f-933f-516819ee81c4},
 created = {2020-09-17T09:27:45.198Z},
 file_attached = {false},
 profile_id = {20f87055-ac78-3c65-9cf5-216a3558d16a},
 group_id = {14ca8526-77d5-34fd-89de-e48cae5e6ee2},
 last_modified = {2020-09-17T09:27:45.198Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 language = {eng},
 private_publication = {false},
 abstract = {While cortical thinning has been associated with HIV infection, it is unclear whether this reflects a direct effect of the virus, whether it is related to disruption of subcortical function or whether it is better explained by epiphenomena, such as drug abuse or comorbid medical conditions. The present study investigated the relationship between cortical thickness and subcortical function in HIV+ patients. Specifically, we examined the relationship between prefrontal cortical thickness and striatal function. Twenty-three largely treatment naïve, non-substance abusing HIV+ participants and 19 healthy controls matched for age, gender, and educational status were included. Cortical morphometry was performed using FreeSurfer software analysis. Striatal function was measured during an fMRI stop-signal anticipation task known to engage the striatum. Any cortical regions showing significant thinning were entered as dependent variables into a single linear regression model which included subcortical function, age, CD4 count, and a measure of global cognitive performance as independent predictors. The only cortical region that was significantly reduced after correction for multiple comparisons was the right superior frontal gyrus. Striatal activity was found to independently predict superior frontal gyral cortical thickness. While cortical thinning in HIV infection is likely multifactorial, viral induced subcortical dysfunction appears to play a role.},
 bibtype = {article},
 author = {du Plessis, Stéfan and Vink, Matthijs and Joska, John A and Koutsilieri, Eleni and Bagadia, Asif and Stein, Dan J and Emsley, Robin},
 journal = {Journal of Neural Transmission (Vienna, Austria: 1996)},
 number = {6}
}

@article{k_sunny_interpreting_2016,
	title = {Interpreting the {Lactulose} {Breath} {Test} for the {Diagnosis} of {Small} {Intestinal} {Bacterial} {Overgrowth}},
	volume = {351},
	issn = {1538-2990},
	doi = {10.1016/j.amjms.2015.12.008},
	abstract = {INTRODUCTION: Based on literature review, a positive lactulose breath test (LBT) for small intestinal bacterial overgrowth requires an initial peak value of hydrogen within 100 minutes of lactulose ingestion with a second peak before 180minutes. However, using scintigraphic monitoring of lactulose transit time, mean oral-cecal arrival time has been reported as 73minutes. The goal was to propose new criteria for analysing the LBT to overcome false positive interpretations.
METHODS: LBTs from our referral center were interpreted as positive after ingestion of 10g of lactulose using the following approach for hydrogen concentrations: (1) The literature guidelines: greater than 20ppm from a baseline less than 10ppm achieved within 100minutes followed by a further rise of greater than 15ppm within 180minutes. (2) The proposed criteria: greater than 20ppm from a baseline less than 10ppm within either 60 or 80minutes followed by a further rise of greater than 15ppm during the 180-minute test.
RESULTS: A total of 153 patients with symptoms suspicious for small-bowel bacterial overgrowth underwent testing. Of all, 26.1\% patients tested positive by 100minutes, 11.8\% patients tested positive by 60minutes and 18.3\% patients tested positive by 80minutes. The percentage of positive LBTs at 60 and 80minutes was significantly lesser than for the 100minutes criteria (P {\textless} 0.05).
CONCLUSIONS: The first hydrogen peak increase should occur by either 60 or 80minutes to increase the specificity of LBT for small intestinal bacterial overgrowth based on the reality of lactulose cecal arrival times.},
	language = {eng},
	number = {3},
	journal = {The American Journal of the Medical Sciences},
	author = {K Sunny, Joseph and Garcia, Cesar J. and McCallum, Richard W.},
	month = mar,
	year = {2016},
	pmid = {26992249},
	keywords = {Adult, Aged, Aged, 80 and over, Bacterial Infections, Bloating, Breath Tests, Diarrhea, Female, Gastrointestinal Agents, Humans, Hydrogen, Intestine, Small, Lactulose, Lactulose breath test, Male, Middle Aged, Retrospective Studies, Small intestinal bacterial overgrowth, Young Adult},
	pages = {229--232},
}

@article{garbati_infections_2016,
	title = {Infections due to {Carbapenem} {Resistant} {Enterobacteriaceae} among {Saudi} {Arabian} {Hospitalized} {Patients}: {A} {Matched} {Case}-{Control} {Study}.},
	volume = {2016},
	issn = {2314-6141},
	abstract = {Background. We conducted this case-control study to determine the risk factors and treatment outcome of infections due to carbapenem resistant Enterobacteriaceae in our institution. Methods. This is a matched case-control study of patients with infection due to carbapenem resistant Enterobacteriaceae (CRE) and carbapenem susceptible Enterobacteriaceae (CSE), from Riyadh, Saudi Arabia, between March 2012 and December 2013. Results. During this period, 29 cases and 58 controls were studied. The mean ages of the cases (55.4 years) and controls (54.7 years) were similar (p = 0.065). Cases had higher mean Charlson comorbidity index (CCI) (3.1) than controls (1.9), p = 0.026. Several factors contributed to infection among the studied population. Prior uses of piperacillin-tazobactam, a carbapenem, a quinolone, and metronidazole were significantly associated with CRE infections. Nine of the cases died compared with 7 of the controls, p = 0.031. Mortality was associated with advanced age, the presence of comorbidities, ICU stay, and receipt of invasive procedures. Conclusions. Infections due to CRE resulted in a significantly increased mortality. Combination antibiotic therapy was associated with reduced mortality. Properly designed randomized controlled studies are required to better characterize these findings.},
	number = {101600173},
	journal = {BioMed research international},
	author = {Garbati, M A and Sakkijha, H and Abushaheen, A},
	year = {2016},
	note = {Garbati, M A. Section of Infectious Diseases, Medical Specialties Department, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
Sakkijha, H. Pulmonary and Critical Care Medicine Department, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
Abushaheen, A. Scientific Research and Publication Center, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.},
	keywords = {*Carbapenems/tu [Therapeutic Use], *Cross Infection/dt [Drug Therapy], *Cross Infection/mo [Mortality], *Drug Resistance, Bacterial, *Enterobacteriaceae Infections/dt [Drug Therapy], *Enterobacteriaceae Infections/mo [Mortality], Aged, 80 and over, Case-Control Studies, Cross Infection/mi [Microbiology], Enterobacteriaceae Infections/mi [Microbiology], Enterobacteriaceae/cl [Classification], Enterobacteriaceae/de [Drug Effects], Enterobacteriaceae/ip [Isolation \& Purification], Hospitalization/sn [Statistics \& Numerical Data], Humans, Risk Factors, Saudi Arabia/ep [Epidemiology], adolescent, adult, aged, female, incidence, male, middle aged, survival rate, treatment outcome, young adult},
	pages = {3961684}
}

@article{arno_mutations_2016,
	title = {Mutations in {REEP6} {Cause} {Autosomal}-{Recessive} {Retinitis} {Pigmentosa}},
	volume = {99},
	issn = {1537-6605},
	doi = {10.1016/j.ajhg.2016.10.008},
	abstract = {Retinitis pigmentosa (RP) is the most frequent form of inherited retinal dystrophy. RP is genetically heterogeneous and the genes identified to date encode proteins involved in a wide range of functional pathways, including photoreceptor development, phototransduction, the retinoid cycle, cilia, and outer segment development. Here we report the identification of biallelic mutations in Receptor Expression Enhancer Protein 6 (REEP6) in seven individuals with autosomal-recessive RP from five unrelated families. REEP6 is a member of the REEP/Yop1 family of proteins that influence the structure of the endoplasmic reticulum but is relatively unstudied. The six variants identified include three frameshift variants, two missense variants, and a genomic rearrangement that disrupts exon 1. Human 3D organoid optic cups were used to investigate REEP6 expression and confirmed the expression of a retina-specific isoform REEP6.1, which is specifically affected by one of the frameshift mutations. Expression of the two missense variants (c.383C{\textgreater}T [p.Pro128Leu] and c.404T{\textgreater}C [p.Leu135Pro]) and the REEP6.1 frameshift mutant in cultured cells suggest that these changes destabilize the protein. Furthermore, CRISPR-Cas9-mediated gene editing was used to produce Reep6 knock-in mice with the p.Leu135Pro RP-associated variant identified in one RP-affected individual. The homozygous knock-in mice mimic the clinical phenotypes of RP, including progressive photoreceptor degeneration and dysfunction of the rod photoreceptors. Therefore, our study implicates REEP6 in retinal homeostasis and highlights a pathway previously uncharacterized in retinal dystrophy.},
	language = {eng},
	number = {6},
	journal = {American Journal of Human Genetics},
	author = {Arno, Gavin and Agrawal, Smriti A. and Eblimit, Aiden and Bellingham, James and Xu, Mingchu and Wang, Feng and Chakarova, Christina and Parfitt, David A. and Lane, Amelia and Burgoyne, Thomas and Hull, Sarah and Carss, Keren J. and Fiorentino, Alessia and Hayes, Matthew J. and Munro, Peter M. and Nicols, Ralph and Pontikos, Nikolas and Holder, Graham E. and {UKIRDC} and Asomugha, Chinwe and Raymond, F. Lucy and Moore, Anthony T. and Plagnol, Vincent and Michaelides, Michel and Hardcastle, Alison J. and Li, Yumei and Cukras, Catherine and Webster, Andrew R. and Cheetham, Michael E. and Chen, Rui},
	month = dec,
	year = {2016},
	pmid = {27889058},
	pmcid = {PMC5142109},
	keywords = {Adolescent, Alleles, Animals, Child, Child, Preschool, Eye Proteins, Female, Genes, Recessive, Humans, Induced Pluripotent Stem Cells, Male, Membrane Transport Proteins, Mice, Mutation, Mutation, Missense, Phenotype, Photoreceptor Cells, Vertebrate, Retinitis Pigmentosa, Young Adult},
	pages = {1305--1315}
}

@article{ozturk_comparison_2016,
	title = {Comparison of {Transcutaneous} {Electrical} {Nerve} {Stimulation} and {Parasternal} {Block} for {Postoperative} {Pain} {Management} after {Cardiac} {Surgery}.},
	volume = {2016},
	issn = {1918-1523},
	abstract = {Background. Parasternal block and transcutaneous electrical nerve stimulation (TENS) have been demonstrated to produce effective analgesia and reduce postoperative opioid requirements in patients undergoing cardiac surgery. Objectives. To compare the effectiveness of TENS and parasternal block on early postoperative pain after cardiac surgery. Methods. One hundred twenty patients undergoing cardiac surgery were enrolled in the present randomized, controlled prospective study. Patients were assigned to three treatment groups: parasternal block, intermittent TENS application, or a control group. Results. Pain scores recorded 4h, 5h, 6h, 7h, and 8h postoperatively were lower in the parasternal block group than in the TENS and control groups. Total morphine consumption was also lower in the parasternal block group than in the TENS and control groups. It was also significantly lower in the TENS group than in the control group. There were no statistical differences among the groups regarding the extubation time, rescue analgesic medication, length of intensive care unit stay, or length of hospital stay. Conclusions. Parasternal block was more effective than TENS in the management of early postoperative pain and the reduction of opioid requirements in patients who underwent cardiac surgery through median sternotomy. This trial is registered with Clinicaltrials.gov number NCT02725229.},
	number = {9612504},
	journal = {Pain research \& management},
	author = {Ozturk, Nilgun Kavrut and Baki, Elif Dogan and Kavakli, Ali Sait and Sahin, Ayca Sultan and Ayoglu, Raif Umut and Karaveli, Arzu and Emmiler, Mustafa and Inanoglu, Kerem and Karsli, Bilge},
	year = {2016},
	note = {Ozturk, Nilgun Kavrut. Department of Anesthesiology and Reanimation, Antalya Education and Research Hospital, Varlik Mahallesi, Kazim Karabekir Cadde, 07100 Antalya, Turkey.
Baki, Elif Dogan. Department of Anesthesiology and Reanimation, Afyon Kocatepe University, Faculty of Medicine, Afyon, Turkey.
Kavakli, Ali Sait. Department of Anesthesiology and Reanimation, Antalya Education and Research Hospital, Varlik Mahallesi, Kazim Karabekir Cadde, 07100 Antalya, Turkey.
Sahin, Ayca Sultan. Department of Anesthesiology and Reanimation, Antalya Education and Research Hospital, Varlik Mahallesi, Kazim Karabekir Cadde, 07100 Antalya, Turkey.
Ayoglu, Raif Umut. Department of Cardiovascular Surgery, Antalya Education and Research Hospital, 07100 Antalya, Turkey.
Karaveli, Arzu. Department of Anesthesiology and Reanimation, Antalya Education and Research Hospital, Varlik Mahallesi, Kazim Karabekir Cadde, 07100 Antalya, Turkey.
Emmiler, Mustafa. Department of Cardiovascular Surgery, Antalya Education and Research Hospital, 07100 Antalya, Turkey.
Inanoglu, Kerem. Department of Anesthesiology and Reanimation, Antalya Education and Research Hospital, Varlik Mahallesi, Kazim Karabekir Cadde, 07100 Antalya, Turkey.
Karsli, Bilge. Department of Algology, Akdeniz University, Faculty of Medicine, 07100 Antalya, Turkey.},
	keywords = {*Cardiac Surgical Procedures/ae [Adverse Effects], *Nerve Block/mt [Methods], *Pain, Postoperative/et [Etiology], *Pain, Postoperative/th [Therapy], *Transcutaneous Electric Nerve Stimulation/mt [Methods], Adjuvants, Anesthesia/tu [Therapeutic Use], Diazepam/tu [Therapeutic Use], Heart Diseases/su [Surgery], Humans, Prospective Studies, Time Factors, adolescent, adult, aged, female, male, middle aged, treatment outcome, visual analog scale, young adult},
	pages = {4261949}
}

@article{short_anthropometric_2015,
	title = {Anthropometric models of bone mineral content and areal bone mineral density based on the bone mineral density in childhood study},
	volume = {26},
	issn = {1433-2965},
	doi = {10.1007/s00198-014-2916-x},
	abstract = {New models describing anthropometrically adjusted normal values of bone mineral density and content in children have been created for the various measurement sites. The inclusion of multiple explanatory variables in the models provides the opportunity to calculate Z-scores that are adjusted with respect to the relevant anthropometric parameters.
INTRODUCTION: Previous descriptions of children's bone mineral measurements by age have focused on segmenting diverse populations by race and sex without adjusting for anthropometric variables or have included the effects of a single anthropometric variable.
METHODS: We applied multivariate semi-metric smoothing to the various pediatric bone-measurement sites using data from the Bone Mineral Density in Childhood Study to evaluate which of sex, race, age, height, weight, percent body fat, and sexual maturity explain variations in the population's bone mineral values. By balancing high adjusted R(2) values with clinical needs, two models are examined.
RESULTS: At the spine, whole body, whole body sub head, total hip, hip neck, and forearm sites, models were created using sex, race, age, height, and weight as well as an additional set of models containing these anthropometric variables and percent body fat. For bone mineral density, weight is more important than percent body fat, which is more important than height. For bone mineral content, the order varied by site with body fat being the weakest component. Including more anthropometrics in the model reduces the overlap of the critical groups, identified as those individuals with a Z-score below -2, from the standard sex, race, and age model.
CONCLUSIONS: If body fat is not available, the simpler model including height and weight should be used. The inclusion of multiple explanatory variables in the models provides the opportunity to calculate Z-scores that are adjusted with respect to the relevant anthropometric parameters.},
	language = {eng},
	number = {3},
	journal = {Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA},
	author = {Short, D. F. and Gilsanz, V. and Kalkwarf, H. J. and Lappe, J. M. and Oberfield, S. and Shepherd, J. A. and Winer, K. K. and Zemel, B. S. and Hangartner, T. N.},
	month = mar,
	year = {2015},
	pmid = {25311106},
	pmcid = {PMC4768717},
	keywords = {Absorptiometry, Photon, Adipose Tissue, Adolescent, Age Factors, Algorithms, Anthropometry, Body Height, Body Weight, Bone Density, Bone and Bones, Child, Child, Preschool, Continental Population Groups, Female, Humans, Longitudinal Studies, Male, Models, Theoretical, Sex Factors, Young Adult},
	pages = {1099--1108}
}

Paper  doi  bibtex   

@article{aboukais_r_RADIATIONASSOCIATED_2015,
title = {Radiation-associated grade 2 meningiomas: A nine patient-series and review of the literature},
volume = {136},
issn = {0303-8467},
url = {http://www.ncbi.nlm.nih.gov/pubmed/26056805},
DOI = {10.1016/j.clineuro.2015.05.022},
Language = {English},
Journal = {Clin. Neurol. Neurosurg.},
author = {{Aboukais R} and {Zairi F} and {Le Rhun E} and {Lejeune JP} and {Devos P} and {Reyns N}},
year = {2015},
keywords = {Adult, Combined Modality Therapy/methods, Female, Humans, Magnetic Resonance Imaging/methods, Male, Meningeal Neoplasms/diagnostic imaging, Meningeal Neoplasms/etiology*, Meningeal Neoplasms/surgery*, Meningioma/diagnostic imaging, Meningioma/etiology*, Meningioma/surgery*, Middle Aged, Neoplasm Grading, Neoplasm Recurrence, Local/diagnosis, Neoplasm Recurrence, Local/surgery*, Radionuclide Imaging, Radiosurgery/adverse effects*, Retrospective Studies, Treatment Outcome, Young Adult},
pages = {10-14}
}

@article{
 title = {Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults},
 type = {article},
 year = {2015},
 identifiers = {[object Object]},
 keywords = {Adolescent,Adult,Aging,Brain,Brain: pathology,Dose-Response Relationship, Drug,Female,Humans,Image Processing, Computer-Assisted,Magnetic Resonance Imaging,Male,Marijuana Smoking,Marijuana Smoking: pathology,Retrospective Studies,Statistics, Nonparametric,Young Adult},
 id = {16df742c-e4c4-381b-a7c2-b594d11f069a},
 created = {2016-01-05T19:45:08.000Z},
 file_attached = {false},
 profile_id = {50a856f4-e41b-3395-a32c-35f3a97eb9f9},
 group_id = {41f9b5d2-912d-3281-b756-e2d6e7ccfec5},
 last_modified = {2016-01-05T19:45:08.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 abstract = {Recent research has suggested that marijuana use is associated with volumetric and shape differences in subcortical structures, including the nucleus accumbens and amygdala, in a dose-dependent fashion. Replication of such results in well controlled studies is essential to clarify the effects of marijuana. To that end, this retrospective study examined brain morphology in a sample of adult daily marijuana users (n = 29) versus nonusers (n = 29) and a sample of adolescent daily users (n = 50) versus nonusers (n = 50). Groups were matched on a critical confounding variable, alcohol use, to a far greater degree than in previously published studies. We acquired high-resolution MRI scans, and investigated group differences in gray matter using voxel-based morphometry, surface-based morphometry, and shape analysis in structures suggested to be associated with marijuana use, as follows: the nucleus accumbens, amygdala, hippocampus, and cerebellum. No statistically significant differences were found between daily users and nonusers on volume or shape in the regions of interest. Effect sizes suggest that the failure to find differences was not due to a lack of statistical power, but rather was due to the lack of even a modest effect. In sum, the results indicate that, when carefully controlling for alcohol use, gender, age, and other variables, there is no association between marijuana use and standard volumetric or shape measurements of subcortical structures. },
 bibtype = {article},
 author = {Weiland, B. J. and Thayer, R. E. and Depue, B. E. and Sabbineni, a. and Bryan, a. D. and Hutchison, K. E.},
 journal = {Journal of Neuroscience}
}

@article{robinson_effects_2015,
	title = {The {Effects} of {Relaxation} {Before} or {After} {Skin} {Damage} on {Skin} {Barrier} {Recovery}: {A} {Preliminary} {Study}},
	volume = {77},
	issn = {1534-7796},
	shorttitle = {The {Effects} of {Relaxation} {Before} or {After} {Skin} {Damage} on {Skin} {Barrier} {Recovery}},
	doi = {10.1097/PSY.0000000000000222},
	abstract = {OBJECTIVES: Psychological interventions administered before wounding can reduce stress and improve healing. However, in many cases, it would be more practical for interventions to be delivered after wounding. This preliminary study investigated whether a brief relaxation intervention could improve healing when administered either before or after skin damage produced by tape stripping in comparison to a control group.
METHODS: One hundred twenty-one healthy adults were randomized into one of three groups: (a) relaxation prestripping group, (b) relaxation poststripping group, or (c) no relaxation. Participants completed measures of stress, fatigue, relaxation, and pain. Relaxation consisted of listening to 20 minutes of guided relaxation, whereas the control condition was quiet reading for 20 minutes. Skin barrier function was measured using transepidermal water loss at baseline, immediately after tape stripping and 25 minutes later.
RESULTS: Relaxation either before or after tape stripping improved skin barrier recovery compared with the control group (F(2,92) = 3.58, p = .032, partial η = 0.074). Participants who took part in the relaxation intervention were significantly more relaxed and reported greater reductions in pain than the control group did 25 minutes after tape stripping. Perceived stress over the last month was not significantly related to healing.
CONCLUSIONS: This study showed that a relaxation intervention had a beneficial effect on skin barrier recovery regardless of whether the intervention was administered before or after wounding. Future research needs to replicate these findings in other wound types and in clinical settings, and investigate the biological mechanisms involved.},
	language = {eng},
	number = {8},
	journal = {Psychosomatic Medicine},
	author = {Robinson, Hayley and Jarrett, Paul and Broadbent, Elizabeth},
	month = oct,
	year = {2015},
	pmid = {26335334},
	note = {00002 },
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Epidermis, Female, Humans, Male, Middle Aged, Recovery of Function, Relaxation Therapy, Skin Physiological Phenomena, Treatment Outcome, Wounds and Injuries, Young Adult},
	pages = {844--852}
}

@article{arnal_human_2015,
	title = {Human screams occupy a privileged niche in the communication soundscape},
	volume = {25},
	issn = {1879-0445},
	doi = {10.1016/j.cub.2015.06.043},
	abstract = {Screaming is arguably one of the most relevant communication signals for survival in humans. Despite their practical relevance and their theoretical significance as innate [1] and virtually universal [2, 3] vocalizations, what makes screams a unique signal and how they are processed is not known. Here, we use acoustic analyses, psychophysical experiments, and neuroimaging to isolate those features that confer to screams their alarming nature, and we track their processing in the human brain. Using the modulation power spectrum (MPS [4, 5]), a recently developed, neurally informed characterization of sounds, we demonstrate that human screams cluster within restricted portion of the acoustic space (between ∼30 and 150 Hz modulation rates) that corresponds to a well-known perceptual attribute, roughness. In contrast to the received view that roughness is irrelevant for communication [6], our data reveal that the acoustic space occupied by the rough vocal regime is segregated from other signals, including speech, a pre-requisite to avoid false alarms in normal vocal communication. We show that roughness is present in natural alarm signals as well as in artificial alarms and that the presence of roughness in sounds boosts their detection in various tasks. Using fMRI, we show that acoustic roughness engages subcortical structures critical to rapidly appraise danger. Altogether, these data demonstrate that screams occupy a privileged acoustic niche that, being separated from other communication signals, ensures their biological and ultimately social efficiency.},
	language = {eng},
	number = {15},
	journal = {Current biology: CB},
	author = {Arnal, Luc H. and Flinker, Adeen and Kleinschmidt, Andreas and Giraud, Anne-Lise and Poeppel, David},
	month = aug,
	year = {2015},
	pmid = {26190070},
	pmcid = {PMC4562283},
	keywords = {Acoustic Stimulation, Adult, Female, Humans, Magnetic Resonance Imaging, Male, Sound, Speech Acoustics, Speech Intelligibility, Speech Perception, Young Adult},
	pages = {2051--2056},
}

Paper  doi  bibtex   

@article{gomes_m_prevalence_2015,
title = {Prevalence of Venoatrial Compression by Lymphadenopathy in Sarcoidosis},
volume = {30},
issn = {0883-5993},
url = {http://www.ncbi.nlm.nih.gov/pubmed/25730555},
DOI = {10.1097/RTI.0000000000000134},
Language = {English},
Journal = {J. Thorac. Imaging},
author = {{Gomes M} and {Bendaoud S} and {Wemeau-Stervinou L} and {Faivre JB} and {Duhamel A} and {Wallaert B} and {Remy J} and {Remy-Jardin M}},
year = {2015},
keywords = {Adult, Aged, Female, Heart Atria/diagnostic imaging, Heart Atria/pathology, Humans, Lymphatic Diseases/complications*, Male, Middle Aged, Prevalence, Pulmonary Veins/diagnostic imaging*, Pulmonary Veins/pathology*, Sarcoidosis/complications*, Tomography, X-Ray Computed*, Young Adult},
pages = {268-273}
}

@article{stervbo_effects_2015,
	title = {Effects of aging on human leukocytes (part {II}): immunophenotyping of adaptive immune {B} and {T} cell subsets},
	volume = {37},
	issn = {1574-4647},
	shorttitle = {Effects of aging on human leukocytes (part {II})},
	doi = {10.1007/s11357-015-9829-2},
	abstract = {Immunosenescence results from a continuous deterioration of immune responses resulting in a decreased response to vaccines. A well-described age-related alteration of the immune system is the decrease of de novo generation of T and B cells. In addition, the accumulation of memory cells and loss of diversity in antigen specificities resulting from a lifetime of exposure to pathogens has also been described. However, the effect of aging on subsets of γδTCR(+) T cells and Tregs has been poorly described, and the efficacy of the recall response to common persistent infections in the elderly remains obscure. Here, we investigated alterations in the subpopulations of the B and T cells among 24 healthy young (aged 19-30) and 26 healthy elderly (aged 53-67) individuals. The analysis was performed by flow cytometry using freshly collected peripheral blood. γδTCR(+) T cells were overall decreased, while CD4(+)CD8(-) cells among γδTCR(+) T cells were increased in the elderly. Helios(+)Foxp3(+) and Helios(-)Foxp3(+) Treg cells were unaffected with age. Recent thymic emigrants, based on CD31 expression, were decreased among the Helios(+)Foxp3(+), but not the Helios(-)Foxp3(+) cell populations. We observed a decrease in Adenovirus-specific CD4(+) and CD8(+) T cells and an increase in CMV-specific CD4(+) T cells in the elderly. Similarly, INFγ(+)TNFα(+) double-positive cells were decreased among activated T cells after Adenovirus stimulation but increased after CMV stimulation. The data presented here indicate that γδTCR(+) T cells might stabilize B cells, and functional senescence might dominate at higher ages than those studied here.},
	language = {eng},
	number = {5},
	journal = {Age (Dordrecht, Netherlands)},
	author = {Stervbo, Ulrik and Bozzetti, Cecilia and Baron, Udo and Jürchott, Karsten and Meier, Sarah and Mälzer, Julia Nora and Nienen, Mikalai and Olek, Sven and Rachwalik, Dominika and Schulz, Axel Ronald and Neumann, Avidan and Babel, Nina and Grützkau, Andreas and Thiel, Andreas},
	month = oct,
	year = {2015},
	pmid = {26324156},
	keywords = {*Immunity, Innate, Adult, Aged, Aging/*immunology, B-Lymphocytes/*immunology, Female, Flow Cytometry, Humans, Immunophenotyping, Lymphocyte Activation/*immunology, Male, Middle Aged, T-Lymphocyte Subsets/*immunology, Young Adult},
	pages = {9829}
}

@article{gawri_link_2014,
	title = {Link {N} is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity},
	volume = {32},
	issn = {1554-527X},
	doi = {10.1002/jor.22653},
	abstract = {Presently, there are no established treatments to prevent, stop or even retard back pain arising from disc degeneration. Previous studies have shown that Link N can act as a growth factor and stimulate the synthesis of proteoglycans and collagens, in IVD. However, the sequences in Link N involved in modulating cellular activity are not well understood. To determine if disc cells can proteolytically process Link N, human disc cells were exposed to native Link N over a 48 h period and mass spectrometric analysis revealed that a peptide spanning residues 1-8 was generated in the presence of AF cells but not NP cells. Link N 1-8 significantly induced proteoglycan production in the presence of IL-1β NP and AF cells, confirming that the biological effect is maintained in the first 8 amino acids of the peptide and indicating that the effect is sustained in an inflammatory environment. Thus Link-N 1-8 could be a promising candidate for biologically induced disc repair, and the identification of such a stable specific peptide may facilitate the design of compounds to promote disc repair and provide alternatives to surgical intervention for early stage disc degeneration.},
	language = {eng},
	number = {9},
	journal = {Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society},
	author = {Gawri, Rahul and Ouellet, Jean and Önnerfjord, Patrik and Alkhatib, Bashar and Steffen, Thomas and Heinegård, Dick and Roughley, Peter and Antoniou, John and Mwale, Fackson and Haglund, Lisbet},
	month = sep,
	year = {2014},
	pmid = {24861010},
	keywords = {Adolescent, Adult, Amino Acid Sequence, Animals, Biological Factors, Cattle, Cells, Cultured, Collagen, Female, Humans, IVD degeneration and regeneration, Intercellular Signaling Peptides and Proteins, Intervertebral Disc, Intervertebral Disc Degeneration, Link N, Lumbar Vertebrae, Male, Middle Aged, Molecular Sequence Data, Peptide Fragments, Proteoglycans, Regeneration, Thoracic Vertebrae, Young Adult, biological repair, organ culture},
	pages = {1189--1197},
}

@article{jhunjhunwala_profile_2014,
	title = {Profile of extrapyramidal manifestations in 85 patients with spinocerebellar ataxia type 1, 2 and 3.},
	volume = {21},
	copyright = {Copyright (c) 2013 Elsevier Ltd. All rights reserved.},
	issn = {1532-2653 0967-5868},
	doi = {10.1016/j.jocn.2013.10.021},
	abstract = {This study aimed to determine the prevalence and type of extrapyramidal signs (EPS) in spinocerebellar ataxia (SCA) type 1, 2 and 3. Eighty-five patients with genetically confirmed SCA (SCA1=40, SCA2=28, SCA3=17) were evaluated for the prevalence and types of EPS. Forty-one SCA patients (48.2\%) had one or more types of EPS. The prevalence of EPS was 60.7\% in SCA2, 52.9\% in SCA3, and 37.5\% in SCA1. Among SCA2 patients, bradykinesia was the most frequent (35.3\%), followed by reduced facial expression, postural tremor and dystonia (29.4\% each), rest tremor, titubation and rigidity (23.5\% each), and lip/jaw tremor and chorea (11.8\% each). In SCA3 the common EPS were bradykinesia (44.4\%), staring look, postural tremor and dystonia (33.3\% each), and reduced facial expression and rigidity (22.2\% each). In SCA1, staring look was the most common (53.3\%), followed by dystonia and bradykinesia (33.3\% each), and postural tremor (26.7\%). In all three groups, there was no significant difference in the mean length of repeat of the abnormal allele between those with and without EPS. To conclude bradykinesia, staring look, dystonia and postural tremor were the most frequent EPS observed in SCA. In SCA1, these signs were seen more often in younger patients with early onset of symptoms.},
	language = {eng},
	number = {6},
	journal = {Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
	author = {Jhunjhunwala, Ketan and Netravathi, M. and Purushottam, Meera and Jain, Sanjeev and Pal, Pramod Kumar},
	month = jun,
	year = {2014},
	pmid = {24602359},
	note = {Place: Scotland},
	keywords = {*Alleles, Adult, Basal Ganglia Diseases/*diagnosis/epidemiology/*genetics, Cohort Studies, Dystonia, Extrapyramidal signs, Female, Humans, Male, Middle Aged, Movement disorders, Parkinsonism, Spinocerebellar Ataxias/*diagnosis/epidemiology/*genetics, Spinocerebellar ataxia, Tremor, Young Adult},
	pages = {1002--1006},
}

@article{vytal_sustained_2014,
	title = {Sustained anxiety increases amygdala-dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults.},
	volume = {39},
	copyright = {All rights reserved},
	issn = {1488-2434 1180-4882},
	doi = {10.1503/jpn.130145},
	abstract = {BACKGROUND: Neuroimaging research has traditionally explored fear and anxiety in response to discrete threat cues (e.g., during fear conditioning). However,  anxiety is a sustained aversive state that can persist in the absence of discrete  threats. Little is known about mechanisms that maintain anxiety states over a  prolonged period. Here, we used a robust translational paradigm (threat of shock)  to induce sustained anxiety. Recent translational work has implicated an  amygdala-prefrontal cortex (PFC) circuit in the maintenance of anxiety in  rodents. To explore the functional homologues of this circuitry in humans, we  used a novel paradigm to examine the impact of sustained anticipatory anxiety on  amygdala-PFC intrinsic connectivity. METHODS: Task-independent fMRI data were  collected in healthy participants during long-duration periods of shock  anticipation and safety. We examined intrinsic functional connectivity. RESULTS:  Our study involved 20 healthy participants. During sustained anxiety, amygdala  activity was positively coupled with dorsomedial PFC (DMPFC) activity. High trait  anxiety was associated with increased amygdala-DMPFC coupling. In addition,  induced anxiety was associated with positive coupling between regions involved in  defensive responding, and decreased coupling between regions involved in  emotional control and the default mode network. LIMITATIONS: Inferences regarding  anxious pathology should be made with caution because this study was conducted in  healthy participants. CONCLUSION: Findings suggest that anticipatory anxiety  increases intrinsic amygdala-DMPFC coupling and that the DMPFC may serve as a  functional homologue for the rodent prefrontal regions by sustaining anxiety.  Future research may use this defensive neural context to identify biomarkers of  risk for anxious pathology and target these circuits for therapeutic  intervention.},
	language = {eng},
	number = {5},
	journal = {Journal of psychiatry \& neuroscience : JPN},
	author = {Vytal, Katherine E. and Overstreet, Cassie and Charney, Danielle R. and Robinson, Oliver J. and Grillon, Christian},
	month = sep,
	year = {2014},
	pmid = {24886788},
	pmcid = {PMC4160361},
	note = {Place: Canada},
	keywords = {Adult, Amygdala/*physiopathology, Anticipation, Anticipation, Psychological/physiology, Anxiety/*physiopathology, Brain Mapping, Electroshock, Fear/physiology, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways/physiopathology, Neuropsychological Tests, Personality, Prefrontal Cortex/*physiopathology, Psychological/physiology, Psychophysics, Young Adult},
	pages = {321--329},
}

@article{ graux_hallucinations_2014,
  title = {Hallucinations and negative symptoms differentially revealed by frontal and temporal responses to speech in schizophrenia},
  volume = {155},
  issn = {1573-2509},
  doi = {10.1016/j.schres.2014.03.007},
  abstract = {BACKGROUND: Auditory verbal hallucinations (AVH) in schizophrenia may arise because of aberrant speech perception. We used an electroencephalography method to examine the neural processes underlying speech perception in schizophrenic patients with hallucinations.
METHODS: Cortical event-related potentials (ERPs) were analyzed topographically (scalp potential and scalp current density (SCD) mapping) in response to the vowel /a/ using a passive paradigm in 26 patients with schizophrenia.
RESULTS: From the SCD distribution of the P1 peak, we showed that, whereas the hallucination score (PSYRATS) was negatively correlated with the amplitude of the frontal currents, the PANSS negative symptom score was negatively correlated with the amplitude of the temporal currents in patients with schizophrenia.
CONCLUSIONS: These results provide evidence that AVH and negative symptoms are associated with abnormal early processing of speech. Whereas AVH are related to decreased early frontal activation, negative symptoms are associated with a reduced early temporal response.},
  language = {eng},
  number = {1-3},
  journal = {Schizophrenia Research},
  author = {Graux, Jérôme and Bidet-Caulet, Aurélie and Bonnet-Brilhault, Frédérique and Camus, Vincent and Bruneau, Nicole},
  month = {May},
  year = {2014},
  pmid = {24703528},
  keywords = {Adult, Analysis of Variance, Brain Mapping, Electroencephalography, Evoked Potentials, Auditory, Female, Frontal Lobe, Hallucinations, Humans, Male, Schizophrenia, Speech Perception, Temporal Lobe, Young Adult},
  pages = {39--44}
}

@article{burgoyne_characterizing_2014,
	title = {Characterizing the ultrastructure of primary ciliary dyskinesia transposition defect using electron tomography},
	volume = {71},
	issn = {1949-3592},
	doi = {10.1002/cm.21171},
	abstract = {Primary ciliary dyskinesia is an autosomal recessive disorder affecting the motility of cilia. There are a range of ultrastructural ciliary defects that lead to associated clinical symptoms including ineffective mucus clearance, reduced lung function, infertility, and left-right isomerism. Mutations in radial spoke head proteins are a known cause of primary ciliary dyskinesia. Ultrastructually these defects are identified by a portion of cilia lacking a central pair and transposed outer microtubular doublets. We have repeatedly observed an intermittent loss of the central pair in patients with a transposition defect. To further understand the central pair changes in these radial spoke head mutations we employ electron tomography, a high resolution electron microscope technique, to elucidate in three dimensions the ultrastructural arrangements caused by mutation of the RSPH4A gene. We thereby provide an explanation of the structures observed by conventional electron microscopy studies. We demonstrate that the central pair can be present within the cilium. In some cilia, the central pair rotates at the base of the axoneme. We propose that it is this rotation that gives rise to an intermittent appearance of the central pair when viewed under conventional electron microscopy. We discuss the potential causes and consequences of these findings. © 2014 Wiley Periodicals, Inc.},
	language = {eng},
	number = {5},
	journal = {Cytoskeleton (Hoboken, N.J.)},
	author = {Burgoyne, Thomas and Lewis, Amy and Dewar, Ann and Luther, Pradeep and Hogg, Claire and Shoemark, Amelia and Dixon, Mellisa},
	month = may,
	year = {2014},
	pmid = {24616277},
	keywords = {Adolescent, Child, Child, Preschool, Cilia, Electron Microscope Tomography, Female, Humans, Image Interpretation, Computer-Assisted, Kartagener Syndrome, Male, Microtubules, Young Adult, central pair, cilia, radial spoke head, respiratory, tomogram},
	pages = {294--301}
}

Paper  doi  abstract   bibtex   

@article{poil_age_2014,
	title = {Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder ({ADHD}).},
	volume = {125},
	issn = {1872-8952},
	url = {http://www.sciencedirect.com/science/article/pii/S1388245714000509},
	doi = {10.1016/j.clinph.2013.12.118},
	abstract = {OBJECTIVE: Objective biomarkers for attention-deficit/hyperactivity disorder (ADHD) could improve diagnostics or treatment monitoring of this psychiatric disorder. The resting electroencephalogram (EEG) provides non-invasive spectral markers of brain function and development. Their accuracy as ADHD markers is increasingly questioned but may improve with pattern classification.

METHODS: This study provides an integrated analysis of ADHD and developmental effects in children and adults using regression analysis and support vector machine classification of spectral resting (eyes-closed) EEG biomarkers in order to clarify their diagnostic value.

RESULTS: ADHD effects on EEG strongly depend on age and frequency. We observed typical non-linear developmental decreases in delta and theta power for both ADHD and control groups. However, for ADHD adults we found a slowing in alpha frequency combined with a higher power in alpha-1 (8-10Hz) and beta (13-30Hz). Support vector machine classification of ADHD adults versus controls yielded a notable cross validated sensitivity of 67\% and specificity of 83\% using power and central frequency from all frequency bands. ADHD children were not classified convincingly with these markers.

CONCLUSIONS: Resting state electrophysiology is altered in ADHD, and these electrophysiological impairments persist into adulthood.

SIGNIFICANCE: Spectral biomarkers may have both diagnostic and prognostic value.},
	number = {8},
	urldate = {2015-03-26},
	journal = {Clinical neurophysiology},
	author = {Poil, S-S and Bollmann, S and Ghisleni, C and O'Gorman, R L and Klaver, P and Ball, J and Eich-Höchli, D and Brandeis, D and Michels, L},
	month = aug,
	year = {2014},
	pmid = {24582383},
	keywords = {Adolescent, Adult, Aged, Aging, Aging: physiology, Attention, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: dia, Attention Deficit Disorder with Hyperactivity: phy, Child, Electroencephalography, Female, Humans, Male, Middle Aged, Prognosis, Regression Analysis, Rest, Rest: physiology, Sensitivity and Specificity, Support Vector Machines, Young Adult},
	pages = {1626--38},
}

Paper  doi  abstract   bibtex   

@article{erol_ventral_2014,
	title = {Ventral prefrontal executive function impairment as a potential endophenotypic marker for bipolar disorder.},
	volume = {68},
	issn = {1502-4725},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23293900},
	doi = {10.3109/08039488.2012.756062},
	abstract = {BACKGROUND: Patients with remitted bipolar disorder have cognitive impairments, particularly in executive functions. However, the findings of studies that investigated cognitive functions in unaffected relatives of patients with bipolar disorder are conflicting.

AIMS: The aim of this study is to investigate executive functions in healthy parents of patients with bipolar I disorder, along with bipolar I disorder patients and matched controls. It has been hypothesized that both patients with bipolar I disorder and their parents would have executive function impairments compared with controls.

METHODS: 25 patients with bipolar I disorder, in full remission, 25 healthy controls that matched the patients with respect to age, gender and education, 50 healthy parents of those patients and 50 healthy controls that matched the parents for age, gender and education were included in the study. All the participants were interviewed with Structured Clinical Interview for DSM-IV-Axis I (SCID-I). Executive functions were assessed using the Verbal Fluency Test (VFT), Trail Making Test (TMT), Wisconsin Card Sorting Test (WCST) and Stroop Test.

RESULTS: Patients performed significantly worse than their matched controls on the VFT, TMT and Stroop tests, but not on the WCST. Parents performed significantly worse than their matched controls on the TMT and Stroop tests, but not on the VFT and WCST.

CONCLUSIONS: Our results bring more evidence that deficits in ventral, but not dorsal prefrontal executive functions are associated with familial vulnerability to bipolar disorder and ventral prefrontal executive function impairments may represent a potential endophenotype for bipolar disorder.},
	number = {1},
	urldate = {2015-08-27},
	journal = {Nordic journal of psychiatry},
	author = {Erol, Almila and Kosger, Ferdi and Putgul, Gulperi and Ersoy, Bilal},
	month = jan,
	year = {2014},
	pmid = {23293900},
	keywords = {Adolescent, Adult, Aged, Biological Markers, Bipolar Disorder, Bipolar Disorder: diagnosis, Bipolar Disorder: psychology, Bipolar disorder, Cognition Disorders, Cognition Disorders: diagnosis, Cognition Disorders: psychology, Diagnostic and Statistical Manual of Mental Disord, Endophenotypes, Endophenotypes: analysis, Executive Function, Executive functions, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parents, Parents: psychology, Relatives., Socioeconomic Factors, Turkey, Young Adult},
	pages = {18--23},
}

Website  abstract   bibtex   

@article{
 title = {Are forward and backward recall the same? A dual-task study of digit recall.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Adult,Attention,Attention: physiology,Executive Function,Executive Function: physiology,Humans,Mathematical Concepts,Mental Recall,Mental Recall: physiology,Space Perception,Space Perception: physiology,Young Adult},
 pages = {519-32},
 volume = {41},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/23263876},
 id = {99159d3e-5274-3213-bef9-d024aca4812a},
 created = {2016-01-12T16:04:56.000Z},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {There is some debate surrounding the cognitive resources underlying backward digit recall. Some researchers consider it to differ from forward digit recall due to the involvement of executive control, while others suggest that backward recall involves visuospatial resources. Five experiments therefore investigated the role of executive-attentional and visuospatial resources in both forward and backward digit recall. In the first, participants completed visuospatial 0-back and 2-back tasks during the encoding of information to be remembered. The concurrent tasks did not differentially disrupt performance on backward digit recall, relative to forward digit recall. Experiment 2 shifted concurrent load to the recall phase instead and, in this case, revealed a larger effect of both tasks on backward recall, relative to forwards recall, suggesting that backward recall may draw on additional resources during the recall phase and that these resources are visuospatial in nature. Experiments 3 and 4 then further investigated the role of visual processes in forward and backward recall using dynamic visual noise (DVN). In Experiment 3, DVN was presented during encoding of information to be remembered and had no effect upon performance. However, in Experiment 4, it was presented during the recall phase, and the results provided evidence of a role for visual imagery in backward digit recall. These results were replicated in Experiment 5, in which the same list length was used for forward and backward recall tasks. The findings are discussed in terms of both theoretical and practical implications.},
 bibtype = {article},
 author = {St Clair-Thompson, H. L. and Allen, R. J.},
 journal = {Memory & cognition},
 number = {4}
}

Paper  abstract   bibtex   

@article{
 title = {A multi-center retrospective analysis of treatment effects and quality of life in adult patients with cranial ependymomas},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Brain Neoplasms,Brain Neoplasms: mortality,Brain Neoplasms: pathology,Brain Neoplasms: therapy,Combined Modality Therapy,Cranial Irradiation,Ependymoma,Ependymoma: mortality,Ependymoma: pathology,Ependymoma: therapy,Female,Follow-Up Studies,Humans,Male,Middle Aged,Neurosurgical Procedures,Prognosis,Quality of Life,Retrospective Studies,Survival Rate,Young Adult},
 pages = {319-27},
 volume = {114},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/23813228},
 month = {9},
 id = {f45c71d6-e421-3cd5-8da7-0d79c822397d},
 created = {2014-04-16T20:14:36.000Z},
 accessed = {2014-04-16},
 file_attached = {true},
 profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
 group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
 last_modified = {2014-12-29T21:45:19.000Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Long term quality of life data of adult patients harboring intracranial ependymomas have not been reported. The role of adjuvant radiation therapy in Grade II ependymomas is unclear and differs from study to study. We therefore sought to retrospectively analyze outcome and quality of life of adult patients that were operated on intracranial ependymomas at four different surgical centers in two countries. All patients were attempted to be contacted via telephone to assess quality of life (QoL) at the time of the telephone interview. The standard EORTC QoL Questionnaire C30 (EORTC QLQ-C30) and the EORTC QLQ-Brain Cancer Module (QLQ-BN20) were used. 64 adult patients with intracranial ependymomas were included in the study. The only factor that was associated with increased survival was age <55 years (p < 0.001). Supratentorial location was correlated with shorter progression free survival than infratentorial location (PFS; p = 0.048). In WHO Grade II tumors local irradiation did not lead to increased PFS (p = 0.888) or overall survival (p = 0.801). Even for incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS (p = 0.911). In a multivariate analysis of QoL, irradiated patients had significantly worse scores in the item "fatigue" (p = 0.037) than non-irradiated patients. Here we present QoL data of adult patients with intracranial ependymomas. Our data show that local radiation therapy may have long-term effects on patients' QoL. Since in the incompletely resected Grade II tumors local irradiation did not lead to a benefit in PFS in this retrospective study, prospective randomized studies are necessary. In addition to age, supratentorial tumor location is associated with a worse prognosis in adult ependymoma patients.},
 bibtype = {article},
 author = {Dützmann, Stephan and Schatlo, Bawarjan and Lobrinus, Alexander and Murek, Michael and Wostrack, Maria and Weiss, Carolin and Schaller, Karl and Raabe, Andreas and Meyer, Bernhard and Goldbrunner, Roland and Franz, Kea and Seifert, Volker and Senft, Christian},
 journal = {Journal of Neuro-Oncology},
 number = {3}
}

@article{tan_identification_2013,
	title = {Identification of a new cyclovirus in cerebrospinal fluid of patients with acute  central nervous system infections.},
	volume = {4},
	issn = {2150-7511},
	doi = {10.1128/mBio.00231-13},
	abstract = {Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4\% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58\%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus.},
	language = {eng},
	number = {3},
	journal = {mBio},
	author = {Tan, Le Van and van Doorn, H. Rogier and Nghia, Ho Dang Trung and Chau, Tran Thi Hong and Tu, Le Thi Phuong and de Vries, Michel and Canuti, Marta and Deijs, Martin and Jebbink, Maarten F. and Baker, Stephen and Bryant, Juliet E. and Tham, Nguyen Thi and BKrong, Nguyen Thi Thuy Chinh and Boni, Maciej F. and Loi, Tran Quoc and Phuong, Le Thi and Verhoeven, Joost T. P. and Crusat, Martin and Jeeninga, Rienk E. and Schultsz, Constance and Chau, Nguyen Van Vinh and Hien, Tran Tinh and van der Hoek, Lia and Farrar, Jeremy and de Jong, Menno D.},
	month = jun,
	year = {2013},
	pmid = {23781068},
	pmcid = {PMC3684831},
	keywords = {Adolescent, Adult, Aged, Animals, Central Nervous System Infections/epidemiology/*virology, Child, Child, Preschool, Circoviridae Infections/epidemiology/*virology, Circoviridae/*classification/genetics/*isolation \& purification, Cluster Analysis, DNA, Viral/chemistry/genetics, Female, Genome, Viral, Humans, Infant, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Prevalence, Prospective Studies, Sequence Analysis, DNA, Vietnam, Young Adult},
	pages = {e00231--00213},
}

@article{dommett_features_2013,
	title = {Features of cancer in teenagers and young adults in primary care: a population-based nested case-control study},
	volume = {108},
	issn = {1532-1827},
	shorttitle = {Features of cancer in teenagers and young adults in primary care},
	doi = {10.1038/bjc.2013.191},
	abstract = {BACKGROUND: Teenagers and young adults (TYA, 15-24 years) diagnosed with cancer report repeated visits to primary care before referral. We investigated associations of symptoms and consultation frequency in primary care with TYA cancers.
METHODS: Population-based, case-control study was carried out using data from the Clinical Practice Research Datalink (CPRD). A total of 1064 TYA diagnosed with cancer were matched to 13,206 controls. Symptoms independently associated with specific cancers were identified. Likelihood ratios (LRs) and positive predictive values (PPVs) were calculated.
RESULTS: In the 3 months before diagnosis, 397 (42.9\%) cases consulted {\textgreater} or =4 times vs 593(11.5\%) controls (odds ratio (OR): 12.1; 95\% CI: 9.7, 15.1), yielding a PPV for any cancer of 0.018\%. The LR of lymphoma with a head/neck mass was 434 (95\% CI: 60, 3158), with a PPV of 0.5\%. Corresponding figures in other cancers included - LR of leukaemia with lymphadenopathy (any site): 29 (95\% CI: 8, 112), PPV 0.015\%; LR of CNS tumour with seizure: 56 (95\% CI: 19, 163), PPV 0.024\%; and LR of sarcoma with lump/mass/swelling: 79 (95\% CI: 24, 264), PPV 0.042\%.
CONCLUSION: Teenagers and young adults with cancer consulted more frequently than controls in the 3 months before diagnosis. Primary care features of cancer match secondary care reports, but were of very low risk; nonetheless, some features increased the likelihood of cancer substantially and should be taken seriously when assessing TYA.},
	language = {eng},
	number = {11},
	journal = {British Journal of Cancer},
	author = {Dommett, R. M. and Redaniel, M. T. and Stevens, M. C. G. and Hamilton, W. and Martin, R. M.},
	month = jun,
	year = {2013},
	pmid = {23619924},
	pmcid = {PMC3681013},
	keywords = {Adolescent, Adult, Case-Control Studies, Great Britain, Humans, Neoplasms, Primary Health Care, Referral and Consultation, Risk, Young Adult},
	pages = {2329--2333}
}

@article{abdul_sultan_incidence_2013,
	title = {The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from {England} and comparative meta-analysis},
	volume = {8},
	issn = {1932-6203},
	shorttitle = {The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data},
	doi = {10.1371/journal.pone.0070310},
	abstract = {BACKGROUND: Recent linkage between primary and secondary care data has provided valuable information for studying heath outcomes that may initially present in different health care settings. The aim of this study was therefore, twofold: to use linked primary and secondary care data to determine an optimum definition for estimating the incidence of first VTE in and around pregnancy; and secondly to conduct a systematic literature review of studies on perinatal VTE incidence with the purpose of comparing our estimates.
METHODS: We used primary care data from the Clinical Practice Research Datalink (CPRD), which incorporates linkages to secondary care contained within Hospital Episode Statistics (HES) between 1997 and 2010 to estimate the incidence rate of VTE in the antepartum and postpartum period. We systematically searched the literature on the incidence of VTE during antepartum and postpartum periods and performed a meta-analysis to provide comparison.
FINDINGS: Using combined CPRD and HES data and a restrictive VTE definition, the absolute rate during the antepartum period and first six weeks postpartum (early postpartum) were 99 (95\%CI 85-116) and 468 (95\%CI 391-561) per 100,000 person-years respectively. These were comparable to the pooled estimates from our meta-analysis (using studies after 2005) during the antepartum period (118/100,000 person-years) and early postpartum (424/100,000 person-years). When we used only secondary care data to identify VTE events, incidence was lower during the early postpartum period (308/100,000 person-years), whereas relying only on primary care data lead to lower incidence during the time around delivery, but higher rates during the postpartum period (558/100,000 person-years).
CONCLUSION: Using combined CPRD and HES data gives estimates of the risk of VTE in and around pregnancy that are comparable to the existing literature. It also provides more accurate estimation of the date of VTE diagnosis which will allow risk stratification during specific pregnancy and postpartum periods.},
	language = {eng},
	number = {7},
	journal = {PloS One},
	author = {Abdul Sultan, Alyshah and Tata, Laila J. and Grainge, Matthew J. and West, Joe},
	year = {2013},
	pmid = {23922975},
	pmcid = {PMC3726432},
	keywords = {Adolescent, Adult, Cohort Studies, England, Female, Humans, Pregnancy Complications, Hematologic, Primary Health Care, Public Health Surveillance, Secondary Care, Venous Thromboembolism, Young Adult, incidence, pregnancy},
	pages = {e70310}
}

@article{hebson_hemodynamic_2013,
	title = {Hemodynamic phenotype of the failing {Fontan} in an adult population},
	volume = {112},
	issn = {0002-9149},
	doi = {10.1016/j.amjcard.2013.08.023},
	abstract = {Fontan failure can occur even with normal systolic ventricular function and often in the context of significant liver disease. We hypothesized that Fontan failure is hemodynamically distinct from traditional heart failure and characterized by low systemic vascular resistance (SVR) index and preserved cardiac index. Twenty-seven symptomatic adult Fontan (SAF) patients who underwent catheterization from 2001 to 2011 constituted our study group. Fifty-four predominantly asymptomatic pediatric Fontan (PF) patients who underwent catheterization during the same period were randomly selected to perform a control:case cohort analysis. Clinical comparisons were made between the 2 groups. The adults were more symptomatic than the PF cohort (New York Heart Association classes I and II or III and IV: 48\% or 52\% [SAF] vs 94\% or 6\% [PF], respectively, p {\textless}0.01). SAF versus PF mean catheterization findings were central venous pressure 18 ± 6 versus 14 ± 3 mm Hg (p {\textless}0.01), SVR index 1,680 ± 368 versus 1,960 ± 550 dyn s/cm 5/m2 (p = 0.02), and cardiac index 2.7 ± 0.8 versus 2.8 ± 0.7 L/min/m2 (p = 0.25). By imaging, the SAF cohort demonstrated a greater incidence of abnormal liver texture changes (96\% vs 75\%, p = 0.04) and nodularity (77\% vs 42\%, p = 0.02). In conclusion, adult patients with failing Fontan circulation had a lower SVR index and similar cardiac index compared with the pediatric cohort. Liver disease in the adults was more advanced. Our data suggest that Fontan failure is a distinct circulatory derangement with hemodynamic features similar to portal hypertension, albeit with limited ability to augment cardiac output. © 2013 Elsevier Inc. All rights reserved.},
	number = {12},
	journal = {American Journal of Cardiology},
	author = {Hebson, CL and McCabe, NM and Elder, RW and Mahle, WT and McConnell, M and Kogon, BE and Veledar, E and Jokhadar, M and Vincent, RN and Sahu, A and Book, WM},
	month = dec,
	year = {2013},
	keywords = {Young Adult},
	pages = {1943--1947}
}

@article{hiratsuka_supplementing_2013,
	title = {Supplementing healthy women with up to 5.0 g/d of {L}-tryptophan has no adverse effects},
	volume = {143},
	issn = {1541-6100},
	doi = {10.3945/jn.112.173823},
	abstract = {Because of the frequent use of L-tryptophan (L-Trp) in dietary supplements, determination of the no-observed-adverse-effect-level is desirable for public health purposes. We therefore assessed the no-observed-adverse-effect-level for L-Trp and attempted to identify a surrogate biomarker for excess L-Trp in healthy humans. A randomized, double-blind, placebo-controlled, crossover intervention study was performed in 17 apparently healthy Japanese women aged 18-26 y with a BMI of ≈ 20 kg/m(2). The participants were randomly assigned to receive placebo (0 g/d) or 1.0, 2.0, 3.0, 4.0, or 5.0 g/d of L-Trp for 21 d each with a 5-wk washout period between trials. Food intake, body weight, general biomarkers in blood and urine, and amino acid composition in blood and urine were not affected by any dose of L-Trp. Administration of up to 5.0 g/d L-Trp had no effect on a profile of mood states category measurement. The urinary excretion of nicotinamide and its catabolites increased in proportion to the ingested amounts of L-Trp, indicating that participants could normally metabolize this amino acid. The urinary excretion of L-tryptophan metabolites, including kynurenine (Kyn), anthranilic acid, kynurenic acid, 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid, and quinolinic acid (QA), all of which are intermediates of the L-TRP→Kyn→QA pathway, was in proportion to L-Trp loading. The response of 3-HK was the most characteristic of these L-Trp metabolites. This finding suggests that the urinary excretion of 3-HK is a good surrogate biomarker for excess L-Trp ingestion.},
	language = {eng},
	number = {6},
	journal = {The Journal of Nutrition},
	author = {Hiratsuka, Chiaki and Fukuwatari, Tsutomu and Sano, Mitsue and Saito, Kuniaki and Sasaki, Satoshi and Shibata, Katsumi},
	month = jun,
	year = {2013},
	pmid = {23616514},
	keywords = {Adolescent, Adult, Biomarkers, Body Mass Index, Cross-Over Studies, Dietary Supplements, Double-Blind Method, Female, Humans, Kynurenic Acid, Kynurenine, Niacinamide, Placebos, Tryptophan, Young Adult, ortho-Aminobenzoates},
	pages = {859--866},
}

Website  abstract   bibtex   

@article{
 title = {Blood/air distribution of volatile organic compounds (VOCs) in a nationally representative sample.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Air Pollutants,Air Pollutants: analysis,Air Pollutants: blood,Child,Chlorobenzenes,Chlorobenzenes: analysis,Chlorobenzenes: blood,Drinking Water,Environmental Monitoring,Female,Gas Chromatography-Mass Spectrometry,Humans,Linear Models,Male,Middle Aged,Multivariate Analysis,Nutrition Surveys,Questionnaires,Smoking,Smoking: blood,Solid Phase Microextraction,United States,Volatile Organic Compounds,Volatile Organic Compounds: analysis,Volatile Organic Compounds: blood,Young Adult},
 pages = {225-32},
 volume = {419},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22285084},
 publisher = {Elsevier B.V.},
 id = {33341907-add2-3a89-9999-74cba0377b37},
 created = {2015-03-09T20:40:30.000Z},
 file_attached = {true},
 profile_id = {03bdbf9c-0848-344e-95e3-9d552532f95c},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 folder_uuids = {94112c8a-2c34-4696-add4-3937d89cec61},
 private_publication = {false},
 abstract = {Volatile organic compounds (VOCs) in human blood are an effective biomarker of environmental exposure and are closely linked to health outcomes. Unlike VOC concentrations in air, which are routinely collected, blood VOC data are not as readily available. This study aims to develop the quantitative relationship between air and blood VOCs by deriving population-based blood/air distribution coefficients (popKs) of ten common VOCs in the general U.S. population. Air and human blood samples were collected from 364 adults aged 20-59 years in 1999-2000 National Health and Nutrition Examination Survey (NHANES). Determinants of popKs were identified using weighted multivariate regression models. In the non-smoking population, median popKs ranged from 3.1 to 77.3, comparable to values obtained in the laboratory. PopKs decreased with increasing airborne VOC concentrations. Smoking elevated popKs by 1.5-3.5 times for aromatic compounds, but did not affect the popKs for methyl tert-butyl ether (MTBE) or chlorinated compounds. Drinking water concentration was a modifier of MTBE's popK. Age, gender, body composition, nor ethnicity affected popKs. PopKs were predictable using linear models with air concentration as the independent variable for both adults and children. This is the first study to estimate blood/air distribution coefficients using simultaneous environmental and biological monitoring on a national population sample. This study was also the first to determine the blood/air distribution coefficient of p-dichlorobenzene, a compound frequently found in indoor environments. These results have applications in exposure assessment, pharmacokinetic analysis, physiologically-based pharmacokinetic (PBPK) modeling, and uncertainty analysis.},
 bibtype = {article},
 author = {Jia, Chunrong and Yu, Xinhua and Masiak, Wasim},
 journal = {The Science of the total environment}
}

@article{looker_lumbar_2012-1,
	title = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: {United} {States}, 2005-2008},
	issn = {0083-1980},
	shorttitle = {Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area},
	abstract = {OBJECTIVE: This report presents bone measurement data from dual-energy X-ray absorptiometry scans of the lumbar spine and proximal femur for persons aged 8 years and over from the National Health and Nutrition Examination Survey (NHANES) 2005-2008.
METHODS: Means, standard deviations, and selected percentiles were calculated for the proximal femur and lumbar spine (total and subregions) by sex, race and ethnicity, and age. Smoothed mean total lumbar spine and femur neck bone mineral density (BMD) were plotted by age, sex, and race and ethnicity. Multiple regression was used to test for significant interactions and to calculate mean total lumbar spine and femur neck BMD after adjusting for age, sex, and race and ethnicity. Differences by sex, race and ethnicity, and age were summarized by calculating the percent difference in adjusted means.
RESULTS: Among scanned individuals, 11\% lacked total lumbar spine data due to invalid data for one or more lumbar vertebrae, and 4\% had invalid data for the proximal femur. Non-Hispanic black persons had 6\% higher total lumbar spine BMD and 9\%-10\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD and femur neck BMD did not differ between Mexican-American and non-Hispanic white persons in those under age 20. For those aged 20 and over, Mexican-American persons had 4\% lower total lumbar spine BMD but 1\% higher femur neck BMD than non-Hispanic white persons. Mean total lumbar spine BMD was 8\%-17\% higher in females aged 8-15 compared with males of the same age. In the age group 16-49, mean total lumbar spine BMD was similar or slightly higher for females compared with males, but after age 50 it was 60\%-15\% lower for females compared with males. Mean femur neck BMD was 5\%-13\% lower for females than males in all age groups except 12-15.},
	language = {eng},
	number = {251},
	journal = {Vital and Health Statistics. Series 11, Data from the National Health Survey},
	author = {Looker, Anne C. and Borrud, Lori G. and Hughes, Jeffery P. and Fan, Bo and Shepherd, John A. and Melton, L. Joseph},
	month = mar,
	year = {2012},
	pmid = {24261130},
	keywords = {Absorptiometry, Photon, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bone Density, Child, Ethnic Groups, Female, Femur, Humans, Lumbar Vertebrae, Male, Middle Aged, Nutrition Surveys, Regression Analysis, Sex Factors, United States, Young Adult},
	pages = {1--132}
}

@article{spoendlin_study_2012,
	title = {A study on the epidemiology of rosacea in the {U}.{K}},
	volume = {167},
	issn = {1365-2133},
	doi = {10.1111/j.1365-2133.2012.11037.x},
	abstract = {BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09\% to 22\%. To our knowledge, incidence rates have not been quantified before.
OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5\% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80\% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8\% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95\% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.},
	language = {eng},
	number = {3},
	journal = {The British Journal of Dermatology},
	author = {Spoendlin, J. and Voegel, J. J. and Jick, S. S. and Meier, C. R.},
	month = sep,
	year = {2012},
	pmid = {22564022},
	keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alcohol Drinking, Child, Child, Preschool, Diagnosis, Differential, Epidemiologic Methods, Female, Great Britain, Humans, Infant, Life Style, Male, Middle Aged, Rosacea, Smoking, Young Adult, incidence},
	pages = {598--605}
}

@article{aviezer_body_2012,
	title = {Body cues, not facial expressions, discriminate between intense positive and negative emotions.},
	volume = {338},
	doi = {10.1126/science.1224313},
	abstract = {The distinction between positive and negative emotions is fundamental in emotion models. Intriguingly, neurobiological work suggests shared mechanisms across positive and negative emotions. We tested whether similar overlap occurs in real-life facial expressions. During peak intensities of emotion, positive and negative situations were successfully discriminated from isolated bodies but not faces. Nevertheless, viewers perceived illusory positivity or negativity in the nondiagnostic faces when seen with bodies. To reveal the underlying mechanisms, we created compounds of intense negative faces combined with positive bodies, and vice versa. Perceived affect and mimicry of the faces shifted systematically as a function of their contextual body emotion. These findings challenge standard models of emotion expression and highlight the role of the body in expressing and perceiving emotions},
	language = {eng},
	number = {6111},
	journal = {Science},
	author = {Aviezer, Hillel and Trope, Yaacov and Todorov, Alexander},
	year = {2012},
	pmid = {23197536},
	note = {Place: United States
ISBN: 1095-9203},
	keywords = {Adolescent, Cues, Emotions, Facial Expression, Female, Humans, Illusions, Kinesics, Male, Perception, Young Adult, randomized controlled trial, research support, u.s. gov't, non-p.h.s.},
	pages = {1225--1229},
}

Paper  doi  abstract   bibtex   

@article{nosarti_preterm_2012,
	title = {Preterm birth and psychiatric disorders in young adult life.},
	volume = {69},
	issn = {1538-3636},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22660967},
	doi = {10.1001/archgenpsychiatry.2011.1374},
	abstract = {CONTEXT: Preterm birth, intrauterine growth restriction, and delivery-related hypoxia have been associated with schizophrenia. It is unclear whether these associations pertain to other adult-onset psychiatric disorders and whether these perinatal events are independent.

OBJECTIVE: To investigate the relationships among gestational age, nonoptimal fetal growth, Apgar score, and various psychiatric disorders in young adult life.

DESIGN: Historical population-based cohort study.

SETTING: Identification of adult-onset psychiatric admissions using data from the National Board of Health and Welfare, Stockholm, Sweden.

PARTICIPANTS: All live-born individuals registered in the nationwide Swedish Medical Birth Register between 1973 and 1985 and living in Sweden at age 16 years by December 2002 (n=1 301 522).

MAIN OUTCOME MEASURES: Psychiatric hospitalization with nonaffective psychosis, bipolar affective disorder, depressive disorder, eating disorder, drug dependency, or alcohol dependency, diagnosed according to the International Classification of Diseases codes for 8 through 10. Cox proportional hazards regression models were used to estimate hazard ratios and 95\% CIs.

RESULTS: Preterm birth was significantly associated with increased risk of psychiatric hospitalization in adulthood (defined as ≥16 years of age) in a monotonic manner across a range of psychiatric disorders. Compared with term births (37-41 weeks), those born at 32 to 36 weeks' gestation were 1.6 (95\% CI, 1.1-2.3) times more likely to have nonaffective psychosis, 1.3 (95\% CI, 1.1-1.7) times more likely to have depressive disorder, and 2.7 (95\% CI, 1.6-4.5) times more likely to have bipolar affective disorder. Those born at less than 32 weeks' gestation were 2.5 (95\% CI, 1.0-6.0) times more likely to have nonaffective psychosis, 2.9 (95\% CI, 1.8-4.6) times more likely to have depressive disorder, and 7.4 (95\% CI, 2.7-20.6) times more likely to have bipolar affective disorder.

CONCLUSIONS: The vulnerability for hospitalization with a range of psychiatric diagnoses may increase with younger gestational age. Similar associations were not observed for nonoptimal fetal growth and low Apgar score.},
	number = {6},
	urldate = {2015-05-26},
	journal = {Archives of general psychiatry},
	author = {Nosarti, Chiara and Reichenberg, Abraham and Murray, Robin M and Cnattingius, Sven and Lambe, Mats P and Yin, Li and MacCabe, James and Rifkin, Larry and Hultman, Christina M},
	month = jun,
	year = {2012},
	pmid = {22660967},
	keywords = {Adolescent, Adult, Age of Onset, Alcoholism, Alcoholism: epidemiology, Alcoholism: etiology, Apgar Score, Bipolar Disorder, Bipolar Disorder: epidemiology, Bipolar Disorder: etiology, Cohort Studies, Depressive Disorder, Depressive Disorder: epidemiology, Depressive Disorder: etiology, Eating Disorders, Eating Disorders: epidemiology, Eating Disorders: etiology, Female, Fetal Growth Retardation, Fetal Growth Retardation: epidemiology, Gestational Age, Hospitalization, Hospitalization: statistics \& numerical data, Humans, Infant, Newborn, Male, Mental Disorders, Mental Disorders: epidemiology, Mental Disorders: etiology, Pregnancy, Premature Birth, Premature Birth: epidemiology, Proportional Hazards Models, Psychotic Disorders, Psychotic Disorders: epidemiology, Psychotic Disorders: etiology, Registries, Risk Factors, Schizophrenia, Schizophrenia: epidemiology, Schizophrenia: etiology, Substance-Related Disorders, Substance-Related Disorders: epidemiology, Substance-Related Disorders: etiology, Sweden, Sweden: epidemiology, Young Adult},
	pages = {E1--8},
}

Paper  doi  bibtex   

@article{wong_are_2012,
	title = {Are there socioeconomic disparities in women having discussions on human papillomavirus vaccine with health care providers?},
	volume = {12},
	issn = {1472-6874},
	url = {http://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104306777&site=ehost-live},
	doi = {10.1186/1472-6874-12-33},
	number = {1},
	journal = {BMC Women's Health},
	author = {Wong, Ker Yi and Do, Young Kyung},
	year = {2012},
	keywords = {Adult, Attitude to Health, Cross Sectional Studies, Female, Health Services Accessibility -- Statistics and Numerical Data, Human, Immunization Programs, Middle Age, Papillomavirus Infections -- Prevention and Control, Papillomavirus Vaccine -- Administration and Dosage, Patient Attitudes, Poverty, Professional-Patient Relations, Singapore, Social Class, Socioeconomic Factors, Women's Health, Young Adult},
	pages = {33--33},
}

@article{ tapia_recollection_2012,
  title = {Recollection of negative information in posttraumatic stress disorder},
  volume = {25},
  issn = {1573-6598},
  doi = {10.1002/jts.21659},
  abstract = {The purpose of the present study was to investigate the effects of posttraumatic stress disorder ({PTSD}) associated with the effects of emotional valence on recall processes in recognition memory. Patients suffering from {PTSD} (n = 15) were compared with 15 nontraumatized patients with anxious and depressive symptoms and with 15 nontraumatized controls on the remember/know paradigm using negative, positive, and neutral words. The {PTSD} group remembered more negative words than the nontraumatized controls, F(1, 42) = 7.20, p = .01, but there was no difference between those with {PTSD} and those with anxiety or depression, F(1, 42) = 2.93, p = .09, or between the latter and controls, F(1, 42) {\textless} 1. This study did not allow us to determine whether this recollection bias for negative information was specific to the {PTSD} status or was triggered by the greater level of anxiety displayed in this group.},
  language = {eng},
  number = {1},
  journal = {Journal of Traumatic Stress},
  author = {Tapia, Géraldine and Clarys, David and Bugaiska, Aurélia and El-Hage, Wissam},
  month = {February},
  year = {2012},
  pmid = {22278745},
  keywords = {Adolescent, Adult, Female, Humans, Interviews as Topic, Male, Mental Recall, Middle Aged, Stress Disorders, Post-Traumatic, Terminology as Topic, Young Adult},
  pages = {120--123}
}

@article{morgan_evaluation_2012,
	title = {Evaluation of adverse outcome in young women with polycystic ovary syndrome versus matched, reference controls: a retrospective, observational study},
	volume = {97},
	issn = {1945-7197},
	shorttitle = {Evaluation of adverse outcome in young women with polycystic ovary syndrome versus matched, reference controls},
	doi = {10.1210/jc.2012-1690},
	abstract = {CONTEXT: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, hyperandrogenism, and dyslipidemia, but the effects of these disturbances on long-term health are not fully understood.
AIM: Our aim was to determine the relative risk of type 2 diabetes, cancer, large-vessel disease (LVD), and all-cause mortality for women diagnosed with PCOS.
DESIGN: Data were extracted from the General Practice Research Database, a longitudinal, anonymized research database derived from nearly 600 primary-care practices in the United Kingdom. Patients with a diagnosis of PCOS between 1990 and 2010 were selected. Patients were matched to two sets of controls. The first set was matched according to primary-care practice and age, and the second was also matched on body mass index. Primary outcome was first incident record of diabetes. Crude rates for diabetes were presented, and time to diabetes was analyzed using Cox proportional hazard models. Secondary outcomes (cancer, LVD, and mortality) were also modeled.
RESULTS: Of 53,303 identified with a diagnosis of PCOS, 21,740 (40.8\%) met the eligibility criteria. Median follow-up was 4.7 yr (interquartile range = 2.0-8.6 yr) in those with PCOS and 5.8 yr (2.7-9.6) in the reference group. Crude rates of diabetes were 5.7 and 1.7 per 1000 patient-years for cases and controls, respectively. The corresponding adjusted hazard ratio was 3.015 (95\% confidence interval = 2.733-3.327). Of cases matched by body mass index, crude rates of diabetes were 4.7 and 2.4 per 1000 patient-years, respectively. The corresponding adjusted hazard ratio was 1.752 (1.514-2.028). No significant difference in BMI-adjusted risk was evident for cancer, LVD, or all-cause mortality.
CONCLUSIONS: During this follow-up period, women with PCOS were not at increased risk of LVD, cancer, or death, but they had increased risk of type 2 diabetes.},
	language = {eng},
	number = {9},
	journal = {The Journal of Clinical Endocrinology and Metabolism},
	author = {Morgan, Christopher L. and Jenkins-Jones, Sara and Currie, Craig J. and Rees, D. Aled},
	month = sep,
	year = {2012},
	pmid = {22767635},
	keywords = {Adult, Body Mass Index, Cardiovascular Diseases, Cerebrovascular Disorders, Cholesterol, Diabetes Mellitus, Type 2, Disease Progression, Endpoint Determination, Female, Follow-Up Studies, Humans, Longitudinal Studies, Neoplasms, Peripheral Vascular Diseases, Polycystic Ovary Syndrome, Primary Health Care, Proportional Hazards Models, Retrospective Studies, Smoking, Treatment Outcome, Young Adult},
	pages = {3251--3260}
}

Paper  doi  abstract   bibtex   

@article{nelson_sociodemographic_2012,
	title = {Sociodemographic {Characteristics}, {Health}, and {Success} at {Obtaining} {Work} among {Latino} {Urban} {Day} {Laborers}},
	volume = {23},
	issn = {10492089},
	url = {https://search.proquest.com/docview/1013613524?accountid=12507},
	doi = {10.1353/hpu.2012.0041},
	abstract = {Background. The purpose of this study was to examine the health and social circumstances, knowledge of and access to health and social services, and success at getting work among urban day laborers. Methods. We conducted an interview survey of 217 men waiting for work at several sites in San Francisco. Results. Day laborers were generally unsuccessful at obtaining work and had less than optimal housing, but supported a number of family members. Over half reported fair or poor health, associated with longer time as a day laborer, poor English proficiency, and financially supporting three or more other people. Awareness of health and social services available to them was low. Discussion. The stress of seeking work daily, separation from family, inadequate housing and lack of health care puts this population at increased risk for disease conditions associated with poor physical and mental health. [PUBLICATION ABSTRACT]},
	language = {English},
	number = {2},
	journal = {Journal of Health Care for the Poor and Underserved},
	author = {Nelson, Jr, BA, Ronald W and Schmotzer, RN, MSN, MPH, PhD, Geri and Burgel, RN, PhD, FAAN, Barbara J and Crothers, BA, Rachel and White, RN, MPH, PhD, Mary C},
	month = may,
	year = {2012},
	note = {Place: Baltimore
Publisher: Johns Hopkins University Press},
	keywords = {Adolescent, Adult, Aged, Behavior, Confidence intervals, Cross-Sectional Studies, Documentation, Emigrants \& Immigrants, Employment, Health Services Accessibility, Health Status, Hispanic Americans, Humans, Informal economy, Interviews, Interviews as Topic, Male, Manual workers, Middle Aged, Occupational health, San Francisco, San Francisco California, Social Class, Social Services And Welfare, Studies, Success, United States--US, Young Adult},
	pages = {797--810},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Poor 1-year survival in elderly patients undergoing nonelective colorectal resection.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Aged, 80 and over,Colectomy,Colectomy: mortality,Fecal Incontinence,Fecal Incontinence: etiology,Female,Follow-Up Studies,Germany,Hospitals, Community,Humans,Male,Middle Aged,Postoperative Complications,Rectal Fistula,Rectal Fistula: mortality,Rectal Fistula: surgery,Reoperation,Retrospective Studies,Survival Rate,Treatment Outcome,Young Adult},
 pages = {788-96},
 volume = {55},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/22706132},
 month = {7},
 id = {44cbf07f-e611-36ee-9a91-0db0119c9971},
 created = {2014-10-14T09:23:25.000Z},
 accessed = {2014-10-13},
 file_attached = {true},
 profile_id = {341834ae-df6e-3305-9ea5-95d94ce15292},
 group_id = {62784a9e-1455-39bf-ae63-5ef2a147689e},
 last_modified = {2017-03-14T15:15:44.505Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 private_publication = {false},
 abstract = {BACKGROUND: Colorectal resection in elderly patients is associated with significant morbidity and mortality, especially in an emergency setting.

OBJECTIVES: This study aims to quantify the risks associated with nonelective colorectal resection up to 1 year after surgery in elderly patients.

DESIGN: This is a population-based observational study.

SETTING: Data were obtained from the Hospital Episode Statistics database.

POPULATION: All patients aged 70 years and older who underwent a nonelective colorectal resection in an English National Health Service Trust hospital between April 2001 and March 2008 were included.

MAIN OUTCOME MEASURES: : The primary outcomes measured were 30-day in hospital mortality, 365-day mortality, unplanned readmission within 28 days of discharge, and duration of hospital stay.

RESULTS: During the study period, 36,767 nonelective colorectal resections were performed in patients aged ≥ 70 years in England. Patients were classified into 3 age groups: A (70-75 years), B (76-80 years), and C (>80 years). Thirty-day mortality was 17.0%, 23.3%, and 31.0% in groups A, B, and C (p < 0.001). The overall 30-day medical complication rate was 33.7%, and the reoperation rate was 6.3%. Cardiac and respiratory complications were significantly higher in group C (22.2% and 18.2%, p < 0.001). Mortality in Group C was 51.2% at 1-year postsurgery. Advanced age was an independent determinant of mortality in risk-adjusted regression analyses.

LIMITATIONS: This is a retrospective analysis of a prospective database. Stage of disease at presentation, severity of complications, and cause of death cannot be ascertained from this database.

CONCLUSIONS: In this population-based study, half of all English patients aged over 80 years undergoing nonelective colorectal resection died within 1 year of surgery. Further research is required to identify perioperative and postdischarge strategies that may improve survival in this vulnerable cohort.},
 bibtype = {article},
 author = {Mamidanna, Ravikrishna and Eid-Arimoku, Lola and Almoudaris, Alex M and Burns, Elaine M and Bottle, Alex and Aylin, Paul and Hanna, George B and Faiz, Omar},
 journal = {Diseases of the colon and rectum},
 number = {7}
}

Paper  abstract   bibtex   

@article{
 title = {Efficacy and effectiveness of influenza vaccines: A systematic review and meta-analysis},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Vaccine effectiveness},
 pages = {36-44},
 volume = {12},
 id = {0f707827-12dc-3fde-a01c-bef2cbdbbf77},
 created = {2015-09-09T15:56:50.000Z},
 file_attached = {true},
 profile_id = {7a0fec24-6ec6-312f-956e-f210abd2cdb7},
 group_id = {943817ab-6073-3383-a1c5-963a6e7efbea},
 last_modified = {2015-09-14T21:03:56.000Z},
 tags = {VDECGA,VDECICIDFLUREV,VDECVE},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {Background: No published meta-analyses have assessed efficacy and effectiveness of licensed influenza vaccines in the USA with sensitive and highly specific diagnostic tests to confirm influenza. Methods: We searched Medline for randomised controlled trials assessing a relative reduction in influenza risk of all circulating influenza viruses during individual seasons after vaccination (efficacy) and observational studies meeting inclusion criteria (effectiveness). Eligible articles were published between Jan 1, 1967, and Feb 15, 2011, and used RT-PCR or culture for confirmation of influenza. We excluded some studies on the basis of study design and vaccine characteristics. We estimated random-effects pooled efficacy for trivalent inactivated vaccine (TIV) and live attenuated influenza vaccine (LAIV) when data were available for statistical analysis (eg, at least three studies that assessed comparable age groups). Findings: We screened 5707 articles and identified 31 eligible studies (17 randomised controlled trials and 14 observational studies). Efficacy of TIV was shown in eight (67%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 59% [95% CI 51-67] in adults aged 18-65 years). No such trials met inclusion criteria for children aged 2-17 years or adults aged 65 years or older. Efficacy of LAIV was shown in nine (75%) of the 12 seasons analysed in ten randomised controlled trials (pooled efficacy 83% [69-91]) in children aged 6 months to 7 years. No such trials met inclusion criteria for children aged 8-17 years. Vaccine effectiveness was variable for seasonal influenza: six (35%) of 17 analyses in nine studies showed significant protection against medically attended influenza in the outpatient or inpatient setting. Median monovalent pandemic H1N1 vaccine effectiveness in five observational studies was 69% (range 60-93). Interpretation: Influenza vaccines can provide moderate protection against virologically confirmed influenza, but such protection is greatly reduced or absent in some seasons. Evidence for protection in adults aged 65 years or older is lacking. LAIVs consistently show highest efficacy in young children (aged 6 months to 7 years). New vaccines with improved clinical efficacy and effectiveness are needed to further reduce influenza-related morbidity and mortality. Funding: Alfred P Sloan Foundation. © 2012 Elsevier Ltd.},
 bibtype = {article},
 author = {Osterholm, Michael T. and Kelley, Nicholas S. and Sommer, Alfred and Belongia, Edward a.},
 journal = {The Lancet Infectious Diseases},
 number = {1}
}

Paper  doi  abstract   bibtex   

@article{luchinger_eegbold_2011,
	title = {{EEG}–{BOLD} correlations during (post-) adolescent brain maturation},
	volume = {56},
	issn = {10538119},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21349336},
	doi = {10.1016/j.neuroimage.2011.02.050},
	abstract = {The transition from adolescence to adulthood is a critical stage in the human lifespan during which the brain still undergoes substantial structural and functional change. The changing frequency composition of the resting state EEG reflects maturation of brain function. This study investigated (post)adolescent brain maturation captured by two independently but simultaneously recorded neuronal signals: EEG and fMRI. Data were collected in a 20 min eyes-open/eyes-closed resting state paradigm. EEG, fMRI-BOLD signal and EEG-BOLD correlations were compared between groups of adults, age 25 (n=18), and adolescents, age 15 (n=18). A typical developmental decrease of low-frequency EEG power was observed even at this late stage of brain maturation. Frequency and condition specific EEG-fMRI correlations proved robust for multiple brain regions. However, no consistent change in the EEG-BOLD correlations was identified that would correspond to the neuronal maturation captured by the EEG. This result indicates that the EEG-BOLD correlation measures a distinct aspect of neurophysiological activity that presumably matures earlier, since it is less sensitive to late maturation than the neuronal activity captured by low-frequency EEG.},
	number = {3},
	urldate = {2015-04-10},
	journal = {NeuroImage},
	author = {Lüchinger, Rafael and Michels, Lars and Martin, Ernst and Brandeis, Daniel},
	month = jun,
	year = {2011},
	pmid = {21349336},
	keywords = {Adolescent, Adult, Aging, Aging: physiology, Alpha Rhythm, Alpha Rhythm: physiology, Brain, Brain: growth \& development, Data Interpretation, Delta Rhythm, Delta Rhythm: physiology, Electroencephalography, Female, Humans, Magnetic Resonance Imaging, Male, Models, Nerve Net, Nerve Net: growth \& development, Nerve Net: physiology, Neurological, Oxygen, Oxygen: blood, Photic Stimulation, Regression Analysis, Rest, Rest: physiology, Statistical, Theta Rhythm, Theta Rhythm: physiology, Young Adult},
	pages = {1493--1505},
}

@article{kelly_london_2011,
	title = {The {London} low emission zone baseline study},
	issn = {1041-5505},
	abstract = {On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter {\textless} or = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these suggested that the clearest signals of change were most likely to be measured near roadsides. The seven key areas were also likely to be of importance in carrying out a study to assess the health outcomes of an air quality intervention like the LEZ. Of the seven key areas, two already had monitoring sites with a full complement of equipment, four had monitoring sites that required upgrades of existing equipment, and one required a completely new installation. With the upgrades and new installations in place, fully ratified (verified) pollutant data (for PM10, PM with an aerodynamic diameter {\textless} or = 2.5 microm [PM2.5], nitrogen oxides [NOx], and ozone [O3] at all sites as well as for particle number, black smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites) were then collected for analysis. In addition, the seven key monitoring sites were supported by other sites in the London Air Quality Network (LAQN). From these, a robust set of baseline air quality data was produced. Data from automatic and manual traffic counters as well as automatic license-plate recognition cameras were used to compile detailed vehicle profiles. This enabled us to establish more precise associations between ambient pollutant concentrations and vehicle emissions. An additional goal of the study was to collect baseline PM data in order to test the hypothesis that changes in traffic densities and vehicle mixes caused by the LEZ would affect the oxidative potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM data set was the first to describe, in detail, the oxidative potential and metal content of the PM10 and PM2.5 of a major city's airshed. PM in London has considerable oxidative potential; clear differences in this measure were found from site to site, with evidence that the oxidative potential of both PM10 and PM2.5 at roadside monitoring sites was higher than at urban background locations. In the PM10 samples this increased oxidative activity appeared to be associated with increased concentrations of copper (Cu), barium (Ba), and bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. In the PM2.5 samples, no simple association could be seen, suggesting that other unmeasured components were driving the increased oxidative potential in this fraction of the roadside samples. These data suggest that two components were contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10 microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived for this baseline study confirmed key observations from a more limited spatial mapping exercise published in our earlier HEI report on the introduction of the London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In addition, the data set in the current report provided robust baseline information on the oxidative potential and metal content of PM found in the London airshed in the period before implementation of the LEZ; the finding that a proportion of the oxidative potential appears in the PM coarse mode and is apparently related to brake wear raises important issues regarding the nature of traffic management schemes. The final goal of this baseline study was to establish the feasibility, in ethical and operational terms, of using the U.K.'s electronic primary-care records to evaluate the effects of the LEZ on human health outcomes. Data on consultations and prescriptions were compiled from a pilot group of general practices (13 distributed across London, with 100,000 patients; 29 situated in the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals were obtained to link individual primary-care records to modeled NOx concentrations by means of post-codes. (To preserve anonymity, the postcodes were removed before delivery to the research team.) A wide range of NOx exposures was found across London as well as within and between the practices examined. Although we observed little association between NOx exposure and smoking status, a positive relationship was found between exposure and increased socioeconomic deprivation. The health outcomes we chose to study were asthma, chronic obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory tract infections, ischemic heart disease, heart failure, and atrial fibrillation. These outcomes were measured as prevalence or incidence. Their distributions by age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord with those reported in the epidemiology literature. No cross-sectional positive associations were found between exposure to NOx and any of the studied health outcomes; some associations were significantly negative. After the pilot study, a suitable primary-care database of London patients was identified, the General Practice Research Database responsible for giving us access to these data agreed to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring privacy of the records was agreed upon. The database included about 350,000 patients who had remained at the same address over the four-year period of the study. Power calculations for a controlled longitudinal analysis were then performed, indicating that for outcomes such as consultations for respiratory illnesses or prescriptions for asthma there was sufficient power to identify a 5\% to 10\% reduction in consultations for patients most exposed to the intervention compared with patients presumed to not be exposed to it. In conclusion, the work undertaken in this study provides a good foundation for future LEZ evaluations. Our extensive monitoring network, measuring a comprehensive set of pollutants (and a range of particle metrics), will continue to provide a valuable tool both for assessing the impact of LEZ regulations on air quality in London and for furthering understanding of the link between PM's composition and toxicity. Finally, we believe that in combination with our modeling of the predicted population-based changes in pollution exposure in London, the use of primary-care databases forms a sound basis and has sufficient statistical power for the evaluation of the potential impact of the LEZ on human health.},
	language = {eng},
	number = {163},
	journal = {Research Report (Health Effects Institute)},
	author = {Kelly, Frank and Armstrong, Ben and Atkinson, Richard and Anderson, H. Ross and Barratt, Ben and Beevers, Sean and Cook, Derek and Green, Dave and Derwent, Dick and Mudway, Ian and Wilkinson, Paul and {HEI Health Review Committee}},
	month = nov,
	year = {2011},
	pmid = {22315924},
	keywords = {Adolescent, Adult, Aged, Air Pollutants, Air Pollution, Child, Child, Preschool, Cross-Sectional Studies, Environmental Exposure, Environmental Monitoring, Female, Health Status, Humans, Infant, London, Longitudinal Studies, Male, Metals, Middle Aged, Nitrogen Oxides, Particulate Matter, Pilot Projects, Primary Health Care, Small-Area Analysis, Smoking, Socioeconomic Factors, Vehicle Emissions, Young Adult},
	pages = {3--79}
}

@article{ wicclair_conscientious_2011,
  title = {Conscientious refusals by hospitals and emergency contraception},
  volume = {20},
  issn = {1469-2147},
  doi = {10.1017/S0963180110000691},
  language = {eng},
  number = {1},
  journal = {Cambridge quarterly of healthcare ethics: {CQ}: the international journal of healthcare ethics committees},
  author = {Wicclair, Mark R},
  month = {January},
  year = {2011},
  pmid = {21223617},
  keywords = {Adolescent, Adult, Catholicism, Child Abuse, Sexual, Choice Behavior, Conscience, Contraception, Postcoital, Contraceptives, Postcoital, Emergency Service, Hospital, Female, Humans, Personal Autonomy, Pregnancy, Pregnancy Tests, Prescription Drugs, Rape, Refusal to Treat, Sex Offenses, Young Adult},
  pages = {130--138}
}

Paper  doi  abstract   bibtex   

@article{gow_stability_2011,
	title = {Stability and change in intelligence from age 11 to ages 70, 79, and 87: the {Lothian} {Birth} {Cohorts} of 1921 and 1936.},
	volume = {26},
	issn = {1939-1498},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/20973608},
	doi = {10.1037/a0021072},
	abstract = {Investigating the predictors of age-related cognitive change is a research priority. However, it is first necessary to discover the long-term stability of measures of cognitive ability because prior cognitive ability level might contribute to the amount of cognitive change experienced within old age. These two issues were examined in the Lothian Birth Cohorts of 1921 and 1936. Cognitive ability data were available from age 11 years when the participants completed the Moray House Test No. 12 (MHT). The Lothian Birth Cohort 1936 (LBC1936) completed the MHT a second time at age 70. The Lothian Birth Cohort 1921 (LBC1921) completed the MHT at ages 79 and 87. We examined cognitive stability and change from childhood to old age in both cohorts, and within old age in the LBC1921. Raw stability coefficients for the MHT from 11-70, 11-79, and 11-87 years were .67, .66, and .51, respectively; and larger when corrected for range restriction in the samples. Therefore, minimum estimates of the variance in later-life MHT accounted for by childhood performance on the same test ranged from 26-44\%. This study also examined, in the LBC1921, whether MHT score at age 11 influenced the amount of change in MHT between ages 79 and 87. It did not. Higher intelligence from early life was apparently protective of intelligence in old age due to the stability of cognitive function across the lifespan, rather than because it slowed the decline experienced in later life.},
	number = {1},
	urldate = {2012-07-23},
	journal = {Psychology and aging},
	author = {Gow, Alan J and Johnson, Wendy and Pattie, Alison and Brett, Caroline E and Roberts, Beverly and Starr, John M and Deary, Ian J},
	month = mar,
	year = {2011},
	pmid = {20973608},
	keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Aging, Aging: physiology, Aging: psychology, Child, Cognition, Cognition: physiology, Female, Humans, Intelligence, Intelligence Tests, Intelligence: physiology, Longitudinal Studies, Male, Middle Aged, Scotland, Young Adult},
	pages = {232--40},
}

Paper  doi  bibtex   

@article{wallaert_b_reduction_2011,
title = {Reduction of Maximal Oxygen Uptake in Sarcoidosis: Relationship with Disease Severity},
volume = {82},
issn = {0025-7931},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21934275},
DOI = {10.1159/000330050},
Language = {English},
Journal = {Respiration},
author = {{Wallaert B} and {Talleu C} and {Wemeau-Stervinou L} and {Duhamel A} and {Robin S} and {Aguilaniu B}},
year = {2011},
keywords = {Adult, Aged, Anaerobic Threshold*, Dyspnea/metabolism*, Dyspnea/physiopathology, Exercise Test/methods, Exercise Tolerance*, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Oxygen/metabolism*, Predictive Value of Tests, Pulmonary Gas Exchange*, Rest, Retrospective Studies, Sarcoidosis/metabolism*, Sarcoidosis/physiopathology, Severity of Illness Index, Young Adult},
pages = {501-508}
}

Paper  doi  abstract   bibtex   

@article{zhang_amoxicillin/clavulanic_2011,
	title = {Amoxicillin/clavulanic acid-warfarin drug interaction: a randomized controlled trial},
	volume = {71},
	issn = {0306-5251},
	shorttitle = {Amoxicillin/clavulanic acid-warfarin drug interaction},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040543/},
	doi = {10.1111/j.1365-2125.2010.03824.x},
	abstract = {AIMS
To investigate whether an interaction exists between amoxicillin/clavulanic acid (amoxiclav) and warfarin in patients treated with stable oral anticoagulant therapy.

METHODS
In a double-blind, cross-over, placebo-controlled study, 12 patients on stable warfarin therapy, received a 7 day amoxiclav regimen or placebo.

RESULTS
The mean maximum increase in INR observed was 0.22 ± 0.3 with amoxiclav vs. 0.24 ± 0.6 with placebo (P= 0.94). The day 7–day 1 factor II, R(–) and S(–) warfarin plasma concentrations were similar during the amoxiclav and placebo study periods (P= 0.81, P= 0.45, P= 0.75, respectively).

CONCLUSION
Amoxiclav did not modify anticoagulation in patients treated with stable warfarin therapy and without infection.},
	number = {2},
	urldate = {2014-06-25TZ},
	journal = {British Journal of Clinical Pharmacology},
	author = {Zhang, Qian and Simoneau, Guy and Verstuyft, Celine and Drouet, Ludovic and dit Sollier, Claire Bal and Alvarez, Jean-Claude and Rizzo-Padoin, Nathalie and Bergmann, Jean Francois and Becquemont, Laurent and Mouly, Stephane},
	month = feb,
	year = {2011},
	pmid = {21219403},
	pmcid = {PMC3040543},
	keywords = {Adult, Aged, Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Anticoagulants, Blood Coagulation, Cross-Over Studies, Double-Blind Method, Drug Interactions, Female, Humans, International Normalized Ratio, Male, Middle Aged, Prothrombin, Warfarin, Young Adult},
	pages = {232--236}
}

Website  abstract   bibtex   

@article{
 title = {Advancing the argument for validity of the Alberta Context Tool with healthcare aides in residential long-term care},
 type = {article},
 year = {2011},
 identifiers = {[object Object]},
 keywords = {Alberta Context Tool (ACT)},
 pages = {107},
 volume = {11},
 websites = {http://bmcmedresmethodol.biomedcentral.com/articles/10.1186/1471-2288-11-107},
 month = {12},
 day = {18},
 id = {6cfd6b22-8bd6-344d-a565-9bf88fb1e055},
 created = {2018-01-17T18:09:46.350Z},
 file_attached = {false},
 profile_id = {369acd69-1fe7-313d-821e-cb7bbe1ddab2},
 group_id = {c58111b6-6088-3a92-94c9-4742fdd13d6f},
 last_modified = {2018-01-23T15:59:04.281Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Estabrooks2011g},
 private_publication = {false},
 abstract = {Organizational context has the potential to influence the use of new knowledge. However, despite advances in understanding the theoretical base of organizational context, its measurement has not been adequately addressed, limiting our ability to quantify and assess context in healthcare settings and thus, advance development of contextual interventions to improve patient care. We developed the Alberta Context Tool (the ACT) to address this concern. It consists of 58 items representing 10 modifiable contextual concepts. We reported the initial validation of the ACT in 2009. This paper presents the second stage of the psychometric validation of the ACT.},
 bibtype = {article},
 author = {Estabrooks, Carole A and Squires, Janet E and Hayduk, Leslie A and Cummings, Greta G and Norton, Peter G},
 journal = {BMC Medical Research Methodology}
}

@article{purkis_but_2011,
	title = {But what about the {Empress} of {Racnoss}? {The} allocation of attention to spiders and {Doctor} {Who} in a visual search task is predicted by fear and expertise.},
	volume = {11},
	doi = {10.1037/a0024415},
	abstract = {If there is a spider in the room, then the spider phobic in your group is most likely to point it out to you. This phenomenon is believed to arise because our attentional systems are hardwired to attend to threat in our environment, and, to a spider phobic, spiders are threatening. However, an alternative explanation is simply that attention is quickly drawn to the stimulus of most personal relevance in the environment. Our research examined whether positive stimuli with no biological or evolutionary relevance could be allocated preferential attention. We compared attention to pictures of spiders with pictures from the TV program Doctor Who, for people who varied in both their love of Doctor Who and their fear of spiders. We found a double dissociation: interference from spider and Doctor-Who-related images in a visual search task was predicted by spider fear and Doctor Who expertise, respectively. As such, allocation of attention reflected the personal relevance of the images rather than their threat content. The attentional system believed to have a causal role in anxiety disorders is therefore likely to be a general system that responds not to threat but to stimulus relevance; hence, nonevolutionary images, such as those from Doctor Who, captured attention as quickly as fear-relevant spider images. Where this leaves the Empress of Racnoss, we are unsure},
	language = {eng},
	number = {6},
	journal = {Emotion},
	author = {Purkis, Helena M and Lester, Kathryn J and Field, Andy P},
	year = {2011},
	pmid = {21707142},
	note = {Place: United States
ISBN: 1931-1516},
	keywords = {Adolescent, Adult, Animals, Attention, Fear, Female, Humans, Male, Middle Aged, Phobic Disorders, Photic Stimulation, Questionnaires, Reaction Time, Spiders, Visual Perception, Young Adult},
	pages = {1484--1488},
}

Paper  doi  abstract   bibtex   

@article{wilmshurst_resilience_2011,
	title = {Resilience and well-being in college students with and without a diagnosis of {ADHD}.},
	volume = {15},
	issn = {1557-1246},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19767597},
	doi = {10.1177/1087054709347261},
	abstract = {The study examines psychological well-being and self-concept in college students diagnosed with ADHD.},
	number = {1},
	urldate = {2012-03-11},
	journal = {Journal of Attention Disorders},
	author = {Wilmshurst, Linda and Peele, Marella and Wilmshurst, Luke},
	month = jan,
	year = {2011},
	pmid = {19767597},
	keywords = {1982, Adolescent, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: psy, Female, Humans, Male, Personal Satisfaction, Psychiatric Status Rating Scales, Psychological, Questionnaires, Resilience, Self Concept, Students, Students: psychology, Universities, Young Adult, adhd, and resilience was initially, by werner and smith, college students, in their longitudinal study, introduced, psychological well-being, resilience, self-concept, the concept of risk},
	pages = {11--7},
}

Paper  doi  abstract   bibtex   

@article{von_hippel_stereotype_2011,
	title = {Stereotype threat and female communication styles.},
	volume = {37},
	issn = {1552-7433},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21646549},
	doi = {10.1177/0146167211410439},
	abstract = {A large body of research has documented the performance-debilitating effects of stereotype threat for individuals, but there is a paucity of research exploring interpersonal consequences of stereotype threat. Two experiments tested the hypothesis that stereotype threat would change the style in which women communicate. Results indicate that women who experience stereotype threat regarding leadership abilities react against the stereotype by adopting a more masculine communication style. Study 2 provides evidence that self-affirmation eliminates this effect of stereotype threat on women's communication styles. A third study demonstrates an ironic consequence of this effect of stereotype threat on women's communication–when women under stereotype threat adopt a more masculine communication style, they are rated as less warm and likeable, and evaluators indicate less willingness to comply with their requests. Theoretical and practical implications of these findings are discussed.},
	number = {10},
	journal = {Personality \& Social Psychology Bulletin},
	author = {von Hippel, Courtney and Wiryakusuma, Cindy and Bowden, Jessica and Shochet, Megan},
	month = oct,
	year = {2011},
	pmid = {21646549},
	keywords = {Adolescent, Adult, Communication, Employment, Female, Humans, Leadership, Middle Aged, Stereotyped Behavior, social identification, young adult},
	pages = {1312--24},
}

@article{nakhai-pour_use_2011,
	title = {Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion},
	volume = {183},
	issn = {1488-2329},
	doi = {10.1503/cmaj.110454},
	abstract = {BACKGROUND: The association between the use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy and the risk of spontaneous abortion remains unclear because of inconsistent research results and the lack of evidence for an effect due to specific types or dosages of nonaspirin NSAIDs. We aimed to quantify the association between having a spontaneous abortion and types and dosages of nonaspirin NSAIDs in a cohort of pregnant women.
METHODS: Using a nested case-control design, we obtained data from the Quebec Pregnancy Registry for 4705 women who had a spontaneous abortion. For each instance, we randomly selected 10 controls from the remaining women in the registry who were matched by index date (date of the spontaneous abortion) and gestational age. Use of nonaspirin NSAIDs (identified by filled prescriptions) and nonuse were compared. We also looked for associations between different types and dosages of nonaspirin NSAIDs and having a spontaneous abortion. Analyses of associations and adjustment for confounding were done using conditional logistic regression.
RESULTS: We identified 4705 cases of spontaneous abortion (352 exposed [7.5\%]); 47 050 controls (1213 exposed [2.6\%]). Adjusting for potential confounders, the use of nonaspirin NSAIDs during pregnancy was significantly associated with the risk of spontaneous abortion (odds ratio [OR] 2.43, 95\% confidence interval [CI] 2.12-2.79). Specifically, use of diclofenac (OR 3.09, 95\% CI 1.96-4.87), naproxen (OR 2.64, 95\% CI 2.13-3.28), celecoxib (OR 2.21, 95\% CI 1.42-3.45), ibuprofen (OR 2.19, 95\% CI 1.61-2.96) and rofecoxib (OR 1.83, 95\% CI 1.24-2.70) alone, and combinations thereof (OR 2.64, 95\% CI 1.59-4.39), were all associated with increased risk of spontaneous abortion. No dose-response effect was seen.
INTERPRETATION: Gestational exposure to any type or dosage of nonaspirin NSAIDs may increase the risk of spontaneous abortion. These drugs should be used with caution during pregnancy.},
	language = {eng},
	number = {15},
	journal = {CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne},
	author = {Nakhai-Pour, Hamid Reza and Broy, Perrine and Sheehy, Odile and Bérard, Anick},
	month = oct,
	year = {2011},
	pmid = {21896698},
	pmcid = {PMC3193112},
	keywords = {Abortion, Spontaneous, Adolescent, Adult, Anti-Inflammatory Agents, Non-Steroidal, Case-Control Studies, Cohort Studies, Confounding Factors (Epidemiology), Dose-Response Relationship, Drug, Female, Humans, Logistic Models, Middle Aged, Odds Ratio, Pregnancy, Registries, Risk, Young Adult},
	pages = {1713--1720},
}

Website  abstract   bibtex   

@article{
 title = {ERPs and neural oscillations during volitional supporession of memory retrieval},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Adolescent,Analysis of Variance,Association Learning,Association Learning: physiology,Biological Clocks,Biological Clocks: physiology,Brain,Brain Mapping,Brain: blood supply,Brain: physiology,Electroencephalography,Emotions,Emotions: physiology,Evoked Potentials,Evoked Potentials: physiology,Female,Humans,Image Processing, Computer-Assisted,Magnetic Resonance Imaging,Male,Mental Recall,Mental Recall: physiology,Oxygen,Oxygen: blood,Photic Stimulation,Reaction Time,Visual Perception,Young Adult},
 pages = {1-10},
 volume = {25},
 websites = {http://www.mitpressjournals.org/doi/abs/10.1162/jocn_a_00418#.Vgcwxo9Viko},
 month = {10},
 publisher = {MIT Press55 Hayward Street, Cambridge, MA 02142-1315USAjournals-info@mit.edu},
 day = {28},
 id = {9e3549f7-2c0d-33e4-84d8-bab5eb144557},
 created = {2015-09-27T00:17:34.000Z},
 accessed = {2015-09-26},
 file_attached = {false},
 profile_id = {50a856f4-e41b-3395-a32c-35f3a97eb9f9},
 group_id = {1d7f53de-0a60-3d99-b9ab-c9b479ac932e},
 last_modified = {2015-11-28T00:03:58.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Depue2010m},
 language = {en},
 abstract = {Although investigations of memory and the dynamics of ERP components and neural oscillations as assessed through EEG have been well utilized, little research into the volitional nature of suppression over memory retrieval have used these methods. Oscillation analyses conducted on the Think/No-Think (TNT) task and volitional suppression of retrieval are of interest to broaden our knowledge of neural oscillations associated not only during successful memory retrieval but also when retrieval is unwanted or suppressed. In the current study, we measured EEG during a TNT task and performed ERP and EEG spectral power band analyses. ERP results replicated other researchers' observations of increases in 500-800 msec parietal effects for items where retrieval was instructed to be elaborated compared with being suppressed. Furthermore, EEG analyses indicated increased alpha (8-12 Hz) and theta (3-8 Hz) oscillations across parietal electrodes for items that were instructed to be suppressed versus those to be elaborated. Additionally, during the second half of the experiment (after repeated attempts at control), increases in theta oscillations were found across both frontal and parietal electrodes for items that were instructed to be suppressed and that were ultimately forgotten versus those ultimately remembered. Increased alpha power for items that were instructed to be suppressed versus elaborated may indicate reductions of retrieval attempts or lack of retrieval success. Increased theta power for items that were instructed to be suppressed versus elaborated may indicate increased or prolonged cognitive control to monitor retrieval events.},
 bibtype = {article},
 author = {Depue, Brendan Eliot and Ketz, Nick and Mollison, Matthew V and Nyhus, Erika and Banich, Marie T and Curran, Tim},
 journal = {Journal of Cognitive Neuroscience},
 number = {10}
}

Paper  doi  abstract   bibtex   

@article{ferguson_results_2010,
	title = {Results of intravascular stent placement for fibrosing mediastinitis.},
	volume = {5},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/20412484},
	doi = {10.1111/j.1747-0803.2010.00387.x},
	abstract = {OBJECTIVE: Fibrosing mediastinitis is a rare disorder characterized by an excessive fibrotic reaction in the mediastinum which can result in compromise of mediastinal structures. We sought to evaluate short- and midterm results of intravascular thoracic vessel stent placement for patients with fibrosing mediastinitis. DESIGN: We reviewed all records of fibrosing mediastinitis patients who were referred for stent placement to treat mediastinal vascular compression over a 7-year period. Catheterization reports and digital angiography were assessed to determine vessel dimension and stent characteristics. PATIENTS: Thirteen catheterizations were performed in six patients (five females, mean age 39 years, range 23-63) with a range of 1-4 per patient. INTERVENTIONS: Four patients were treated with intravascular stents placed percutaneously. One patient underwent surgical intravascular stent placement, and one patient declined surgical therapy. The right pulmonary artery was treated in three patients, the superior vena cava was treated in one patient, and three pulmonary veins were treated in one patient. OUTCOME MEASURES: Pertinent vessel and hemodynamics including immediate short-, and mid-term results were assessed. Procedural complications, midterm follow-up (up to 7 years), and overall survival were determined. RESULTS: Each intervention resulted in hemodynamic improvement with subsequent clinical improvement. Reintervention was required within 12 months in two of four percutaneously treated patients. One death occurred 4 days after cutting balloon angioplasty in a preexisting pulmonary vein stent. CONCLUSIONS: Percutaneous therapy for vessel compression secondary to fibrosing mediastinitis is an option that is effective in improving short-term vascular patency. In-stent stenosis was a frequent complication in patients with fibrosing mediastinitis, particularly when pulmonary veins were involved. Short- and midterm success can be achieved, but progressive fibrosing mediastinitis remains a difficult clinical problem with repeat dilation of stents and/or additional stent placement necessary to maintain optimal stent patency and improvement in clinical symptomatology.},
	language = {eng},
	number = {2},
	journal = {Congenit Heart Dis},
	author = {Ferguson, ME and Cabalka, AK and Cetta, F and Hagler, DJ},
	month = mar,
	year = {2010},
	keywords = {Young Adult},
	pages = {124--133}
}

@article{cornish_risk_2010,
	title = {Risk of death during and after opiate substitution treatment in primary care: prospective observational study in {UK} {General} {Practice} {Research} {Database}},
	volume = {341},
	issn = {1756-1833},
	shorttitle = {Risk of death during and after opiate substitution treatment in primary care},
	abstract = {OBJECTIVE: To investigate the effect of opiate substitution treatment at the beginning and end of treatment and according to duration of treatment.
DESIGN: Prospective cohort study. Setting UK General Practice Research Database.
PARTICIPANTS: Primary care patients with a diagnosis of substance misuse prescribed methadone or buprenorphine during 1990-2005. 5577 patients with 267 003 prescriptions for opiate substitution treatment followed-up (17 732 years) until one year after the expiry of their last prescription, the date of death before this time had elapsed, or the date of transfer away from the practice.
MAIN OUTCOME MEASURES: Mortality rates and rate ratios comparing periods in and out of treatment adjusted for sex, age, calendar year, and comorbidity; standardised mortality ratios comparing opiate users' mortality with general population mortality rates.
RESULTS: Crude mortality rates were 0.7 per 100 person years on opiate substitution treatment and 1.3 per 100 person years off treatment; standardised mortality ratios were 5.3 (95\% confidence interval 4.0 to 6.8) on treatment and 10.9 (9.0 to 13.1) off treatment. Men using opiates had approximately twice the risk of death of women (morality rate ratio 2.0, 1.4 to 2.9). In the first two weeks of opiate substitution treatment the crude mortality rate was 1.7 per 100 person years: 3.1 (1.5 to 6.6) times higher (after adjustment for sex, age group, calendar period, and comorbidity) than the rate during the rest of time on treatment. The crude mortality rate was 4.8 per 100 person years in weeks 1-2 after treatment stopped, 4.3 in weeks 3-4, and 0.95 during the rest of time off treatment: 9 (5.4 to 14.9), 8 (4.7 to 13.7), and 1.9 (1.3 to 2.8) times higher than the baseline risk of mortality during treatment. Opiate substitution treatment has a greater than 85\% chance of reducing overall mortality among opiate users if the average duration approaches or exceeds 12 months.
CONCLUSIONS: Clinicians and patients should be aware of the increased mortality risk at the start of opiate substitution treatment and immediately after stopping treatment. Further research is needed to investigate the effect of average duration of opiate substitution treatment on drug related mortality.},
	language = {eng},
	journal = {BMJ (Clinical research ed.)},
	author = {Cornish, Rosie and Macleod, John and Strang, John and Vickerman, Peter and Hickman, Matt},
	year = {2010},
	pmid = {20978062},
	pmcid = {PMC2965139},
	keywords = {Adolescent, Adult, Buprenorphine, Female, Great Britain, Humans, Male, Methadone, Middle Aged, Narcotics, Opioid-Related Disorders, Prospective Studies, Risk Factors, Time Factors, Young Adult},
	pages = {c5475}
}

@article{moller_analysis_2010,
	title = {Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study},
	volume = {10},
	issn = {1471-2334},
	shorttitle = {Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis},
	doi = {10.1186/1471-2334-10-154},
	abstract = {BACKGROUND: Interferon gamma is a major macrophage-activating cytokine during infection with Mycobacterium tuberculosis, the causative pathogen of tuberculosis, and its role has been well established in animal models and in humans. This cytokine is produced by activated T helper 1 cells, which can best deal with intracellular pathogens such as M. tuberculosis. Based on the hypothesis that genes which regulate interferon gamma may influence tuberculosis susceptibility, we investigated polymorphisms in eight candidate genes.
METHODS: Fifty-four polymorphisms in eight candidate genes were genotyped in over 800 tuberculosis cases and healthy controls in a population-based case-control association study in a South African population. Genotyping methods used included the SNPlex Genotyping System, capillary electrophoresis of fluorescently labelled PCR products, TaqMan SNP genotyping assays or the amplification mutation refraction system. Single polymorphisms as well as haplotypes of the variants were tested for association with TB using statistical analyses.
RESULTS: A haplotype in interleukin 12B was nominally associated with tuberculosis (p = 0.02), but after permutation testing, done to assess the significance for the entire analysis, this was not globally significant. In addition a novel allele was found for the interleukin 12B D5S2941 microsatellite.
CONCLUSIONS: This study highlights the importance of using larger sample sizes when attempting validation of previously reported genetic associations. Initial studies may be false positives or may propose a stronger genetic effect than subsequently found to be the case.},
	language = {eng},
	journal = {BMC infectious diseases},
	author = {Möller, Marlo and Nebel, Almut and van Helden, Paul D. and Schreiber, Stefan and Hoal, Eileen G.},
	year = {2010},
	pmid = {20525402},
	pmcid = {PMC2891757},
	note = {00022 },
	keywords = {Adolescent, Adult, Female, Genetic Predisposition to Disease, Genotype, Humans, Interferon-gamma, Male, Molecular Sequence Data, Mycobacterium tuberculosis, Polymorphism, Genetic, South Africa, Tuberculosis, Young Adult},
	pages = {154},
}

Paper  doi  abstract   bibtex   

@article{kim_noninvasive_2010,
	title = {Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults.},
	volume = {12},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/19908166},
	doi = {10.1007/s12028-009-9305-x},
	abstract = {BACKGROUND: This study assesses the utility of a hybrid optical instrument for noninvasive transcranial monitoring in the neurointensive care unit. The instrument is based on diffuse correlation spectroscopy (DCS) for measurement of cerebral blood flow (CBF), and near-infrared spectroscopy (NIRS) for measurement of oxy- and deoxy-hemoglobin concentration. DCS/NIRS measurements of CBF and oxygenation from frontal lobes are compared with concurrent xenon-enhanced computed tomography (XeCT) in patients during induced blood pressure changes and carbon dioxide arterial partial pressure variation. METHODS: Seven neurocritical care patients were included in the study. Relative CBF measured by DCS (rCBF(DCS)), and changes in oxy-hemoglobin (DeltaHbO(2)), deoxy-hemoglobin (DeltaHb), and total hemoglobin concentration (DeltaTHC), measured by NIRS, were continuously monitored throughout XeCT during a baseline scan and a scan after intervention. CBF from XeCT regions-of-interest (ROIs) under the optical probes were used to calculate relative XeCT CBF (rCBF(XeCT)) and were then compared to rCBF(DCS). Spearman's rank coefficients were employed to test for associations between rCBF(DCS) and rCBF(XeCT), as well as between rCBF from both modalities and NIRS parameters. RESULTS: rCBF(DCS) and rCBF(XeCT) showed good correlation (r (s) = 0.73, P = 0.010) across the patient cohort. Moderate correlations between rCBF(DCS) and DeltaHbO(2)/DeltaTHC were also observed. Both NIRS and DCS distinguished the effects of xenon inhalation on CBF, which varied among the patients. CONCLUSIONS: DCS measurements of CBF and NIRS measurements of tissue blood oxygenation were successfully obtained in neurocritical care patients. The potential for DCS to provide continuous, noninvasive bedside monitoring for the purpose of CBF management and individualized care is demonstrated.},
	language = {eng},
	number = {2},
	journal = {Neurocrit Care},
	author = {Kim, MN and Durduran, T and Frangos, S and Edlow, BL and Buckley, EM and Moss, HE and Zhou, C and Yu, G and Choe, R and Maloney-Wilensky, E and Wolf, RL and Grady, MS and Greenberg, JH and Levine, JM and Yodh, AG and Detre, JA and Kofke, WA},
	month = apr,
	year = {2010},
	keywords = {Young Adult},
	pages = {173--180}
}

Paper  doi  abstract   bibtex   

@article{chicaExogenousAttentionCan2010,
	title = {Exogenous attention can capture perceptual consciousness: {ERP} and behavioural evidence},
	volume = {51},
	issn = {1095-9572},
	shorttitle = {Exogenous attention can capture perceptual consciousness},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/20211272},
	doi = {10/b5m63d},
	abstract = {Attention has often been conceived as the gateway to consciousness. However, recent research points to the independence of top-down or endogenous attention and conscious perception, while the role of bottom-up or exogenous attention in conscious perception remains largely unexplored. Here, we present behavioural and electrophysiological evidence exploring the role of exogenous attention in conscious perception. Using peripheral non-informative cues, exogenous attention was oriented either to the same location of a near-threshold target (valid cues), or to the opposite location (invalid cues). Confirming previous research, consciously perceived targets elicited a larger P300 than unseen targets. Importantly, analysis of cue-locked potentials revealed the novel finding that there was a systematic relationship between the amplitude of a P100 component elicited by the cues and the conscious perception of the targets. Valid cues led to the conscious perception of the subsequent targets when they captured attention to their location, as indexed by the P100 component distributed over occipito-parietal areas. On the other hand, invalid cues led to the conscious perception of the subsequent targets only when they failed to capture attention at their location (opposite to the target location). These results suggest that exogenous orienting plays a crucial role in conscious perception.},
	number = {3},
	urldate = {2012-05-18},
	journal = {NeuroImage},
	author = {Chica, Ana B and Lasaponara, Stefano and Lupiáñez, Juan and Doricchi, Fabrizio and Bartolomeo, Paolo},
	month = jul,
	year = {2010},
	pmid = {20211272},
	keywords = {Adult, Female, Humans, Male, *Attention, Human, *Discrimination Learning, Attention, Adolescent, Visual Perception, Cues, Electroencephalography, *Inhibition (Psychology), Young Adult, Brain, *Orientation, Eye Movements, Psychophysics, *Reaction Time, Consciousness, consciousness, Evoked Potentials, Visual, \#nosource},
	pages = {1205--1212},
	annote = {PAPERS},
	file = {Chica et al_2010_Exogenous attention can capture perceptual consciousness.pdf:/Users/paolobartolomeo/PICNIC Lab Dropbox/Paolo Bartolomeo/zotero/pdf/pdf/Chica et al_2010_Exogenous attention can capture perceptual consciousness.pdf:application/pdf},
}

@article{colibazzi_neural_2010,
	title = {Neural systems subserving valence and arousal during the experience of induced emotions.},
	volume = {10},
	doi = {10.1037/a0018484},
	abstract = {The circumplex model of affect construes all emotions as linear combinations of 2 independent neurophysiological dimensions, valence and arousal. We used functional magnetic resonance imaging to identify the neural networks subserving valence and arousal, and we assessed, in 10 participants, the associations of the BOLD (blood oxygen level-dependent) response, an indirect index of neural activity, with ratings of valence and arousal during the emotional experiences induced by the presentation of evocative sentences. Unpleasant emotional experience was associated with increased BOLD signal intensities in the supplementary motor, anterior midcingulate, right dorsolateral prefrontal, occipito-temporal, inferior parietal, and cerebellar cortices. Highly arousing emotions were associated with increased BOLD signal intensities in the left thalamus, globus pallidus, caudate, parahippocampal gyrus, amygdala, premotor cortex, and cerebellar vermis. Separate analyses using a finite impulse response model confirmed these results and revealed that pleasant emotions engaged an additional network that included the midbrain, ventral striatum, and caudate nucleus, all portions of a reward circuit. These findings suggest the existence of distinct networks subserving the valence and arousal dimensions of emotions, with midline and medial temporal lobe structures mediating arousal and dorsal cortical areas and mesolimbic pathways mediating valence.},
	language = {eng},
	number = {3},
	journal = {Emotion},
	author = {Colibazzi, Tiziano and Posner, Jonathan and Wang, Zhishun and Gorman, Daniel and Gerber, Andrew and Yu, Shan and Zhu, Hongtu and Kangarlu, Alayar and Duan, Yunsuo and Russell, James A and Peterson, Bradley S},
	year = {2010},
	pmid = {20515226},
	note = {Place: United States
ISBN: 1931-1516},
	keywords = {Adult, Amygdala, Arousal, Brain, Caudate Nucleus, Cerebellar Cortex, Emotions, Female, Globus Pallidus, Humans, Magnetic Resonance Imaging, Male, MicroValence, Parahippocampal Gyrus, Thalamus, To Read, Young Adult},
	pages = {377--389},
}

@article{ mclean_muslim_2010,
  title = {Muslim women and medical students in the clinical encounter},
  volume = {44},
  issn = {1365-2923},
  doi = {10.1111/j.1365-2923.2009.03599.x},
  abstract = {{CONTEXT}: Increasingly, male medical students report being refused by female patients, particularly in obstetrics and gynaecology, which is impacting on recruitment into the discipline. However, little has been documented in terms of Muslim patients and medical students in the clinical consultation.
{METHODS}: Female Emirati nationals (n = 218) attending out-patient clinics at a public hospital in Al Ain, United Arab Emirates ({UAE}), were interviewed by medical students. Participants were provided with four hypothetical clinical scenarios (three personal, one concerning a pre-pubertal child) and asked whether they would allow male and female students to be present at a consultation, take a history or perform an examination. They were also canvassed about their past experiences with medical students and their social responsibility to contribute towards the training of Emirati doctors.
{RESULTS}: Significant differences were recorded in terms of female versus male student involvement for all activities (P {\textless} 0.05-0.0005). For gynaecological and abdominal problems, patients would generally refuse male students. More than 50% of interviewees would not allow a male student to examine their face. Students of either gender could, however, examine their 8-year-old child. Although 47% of the women had had previous clinical encounters with students, in only 58% of consultations had the attending doctor asked their permission. Despite this, the women had generally felt comfortable, although satisfaction decreased with increasing age (P = 0.088). Almost 90% of the women believed that Emiratis had a social responsibility to contribute towards the training of Emirati doctors, but this decreased with increasing income (P = 0.004).
{CONCLUSIONS}: As many medical students will encounter Muslim patients during their training, they need to be sensitive to religious and cultural issues, particularly for personal examinations. In contexts where most patients are Muslim, alternative options (e.g. manikins, international rotations) may be required for male students. In the {UAE}, patient education may improve history-taking opportunities but will probably not transcend religious and cultural beliefs without intervention from religious leaders.},
  language = {eng},
  number = {3},
  journal = {Medical education},
  author = {McLean, Michelle and Al Ahbabi, Salma and Al Ameri, Mouza and Al Mansoori, Muneera and Al Yahyaei, Fatima and Bernsen, Roos},
  month = {March},
  year = {2010},
  pmid = {20444062},
  keywords = {Abdomen, Adolescent, Adult, Aged, Child, Choice Behavior, Education, Medical, Face, Female, Gynecology, Humans, Islam, Male, Middle Aged, Outpatient Clinics, Hospital, Patient Acceptance of Health Care, Patient Satisfaction, Questionnaires, Sex Factors, Social Responsibility, Students, Medical, United Arab Emirates, Young Adult},
  pages = {306--315}
}

Website  abstract   bibtex   

@article{
 title = {An fMRI study of parietal cortex involvement in the visual guidance of locomotion.},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Adult,Brain Mapping,Cues,Distance Perception,Distance Perception: physiology,Dominance, Cerebral,Dominance, Cerebral: physiology,Female,Fixation, Ocular,Fixation, Ocular: physiology,Humans,Image Processing, Computer-Assisted,Kinesthesis,Kinesthesis: physiology,Locomotion,Locomotion: physiology,Magnetic Resonance Imaging,Male,Nerve Net,Nerve Net: physiology,Optic Flow,Optic Flow: physiology,Orientation,Orientation: physiology,Oxygen Consumption,Oxygen Consumption: physiology,Parietal Lobe,Parietal Lobe: physiology,Psychomotor Performance,Psychomotor Performance: physiology,Saccades,Saccades: physiology,Visual Perception,Visual Perception: physiology,Young Adult},
 pages = {1495-507},
 volume = {36},
 websites = {http://psycnet.apa.org/journals/xhp/36/6/1495.html},
 month = {12},
 publisher = {American Psychological Association},
 day = {1},
 id = {d6e8443d-ed66-3783-81b3-3c281afdea75},
 created = {2016-01-20T16:02:53.000Z},
 accessed = {2015-12-10},
 file_attached = {false},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2016-01-21T12:29:57.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 language = {English},
 abstract = {Locomoting through the environment typically involves anticipating impending changes in heading trajectory in addition to maintaining the current direction of travel. We explored the neural systems involved in the "far road" and "near road" mechanisms proposed by Land and Horwood (1995) using simulated forward or backward travel where participants were required to gauge their current direction of travel (rather than directly control it). During forward egomotion, the distant road edges provided future path information, which participants used to improve their heading judgments. During backward egomotion, the road edges did not enhance performance because they no longer provided prospective information. This behavioral dissociation was reflected at the neural level, where only simulated forward travel increased activation in a region of the superior parietal lobe and the medial intraparietal sulcus. Providing only near road information during a forward heading judgment task resulted in activation in the motion complex. We propose a complementary role for the posterior parietal cortex and motion complex in detecting future path information and maintaining current lane positioning, respectively.},
 bibtype = {article},
 author = {Billington, Jac and Field, David T and Wilkie, Richard M and Wann, John P},
 journal = {Journal of experimental psychology. Human perception and performance},
 number = {6}
}

@Article{Zacks2009,
  author   = {J. M. Zacks and Shawn Kumar and Richard A Abrams and Ritesh Mehta},
  journal  = {Cognition},
  title    = {Using movement and intentions to understand human activity.},
  year     = {2009},
  number   = {2},
  pages    = {201-16},
  volume   = {112},
  abstract = {During perception, people segment continuous activity into discrete
	events. They do so in part by monitoring changes in features of an
	ongoing activity. Characterizing these features is important for
	theories of event perception and may be helpful for designing information
	systems. The three experiments reported here asked whether the body
	movements of an actor predict when viewers will perceive event boundaries.
	Body movements were recorded using a magnetic motion tracking system
	and compared with viewers' segmentation of his activity into events.
	Changes in movement features were strongly associated with segmentation.
	This was more true for fine-grained than for coarse-grained boundaries,
	and was strengthened when the stimulus displays were reduced from
	live-action movies to simplified animations. These results suggest
	that movement variables play an important role in the process of
	segmenting activity into meaningful events, and that the influence
	of movement on segmentation depends on the availability of other
	information sources.},
  doi      = {10.1016/j.cognition.2009.03.007},
  keywords = {Adolescent, Female, Functional Laterality, Humans, Male, Motion Pictures as Topic, Motor Activity, Movement, Perception, Set (Psychology), Young Adult, 19497569},
}

Paper  abstract   bibtex   

@article{
 id = {8364c8e1-57a1-3484-94df-1bd37d5d7010},
 title = {Nonlinear measure of synchrony between blood oxygen saturation and heart rate from nocturnal pulse oximetry in obstructive sleep apnoea syndrome.},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Adult,Aged,Aged, 80 and over,Algorithms,Data Interpretation, Statistical,Entropy,Female,Heart Rate,Heart Rate: physiology,Humans,Male,Middle Aged,Nonlinear Dynamics,Oximetry,Oxygen,Oxygen: blood,Polysomnography,ROC Curve,Reproducibility of Results,Sleep Apnea, Obstructive,Sleep Apnea, Obstructive: blood,Sleep Apnea, Obstructive: physiopathology,Young Adult},
 created = {2012-06-13T03:54:21.000Z},
 pages = {967-82},
 volume = {30},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19696463},
 month = {9},
 accessed = {2010-08-14},
 file_attached = {true},
 profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
 group_id = {ba0deb47-e19a-3151-83cc-b6262d5edb6e},
 last_modified = {2014-07-19T19:17:42.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Alvarez2009b},
 client_data = {"desktop_id":"5adc2c25-73db-4b77-aed2-d32a75858a27"},
 abstract = {This study focuses on analysis of the relationship between changes in blood oxygen saturation (SaO(2)) and heart rate (HR) recordings from nocturnal pulse oximetry (NPO) in patients suspected of suffering from obstructive sleep apnoea (OSA) syndrome. Two different analyses were developed: a classical frequency analysis based on the magnitude squared coherence (MSC) and a nonlinear analysis by means of a recently developed measure of synchrony, the cross-approximate entropy (cross-ApEn). A data set of 187 subjects was studied. We found significantly higher correlation and synchrony between oximetry signals from OSA positive patients compared with OSA negative subjects. We assessed the diagnostic ability to detect OSA syndrome of both the classical and nonlinear approaches by means of receiver operating characteristic (ROC) analyses with tenfold cross-validation. The nonlinear measure of synchrony significantly improved the results obtained with classical MSC: 69.2% sensitivity, 90.9% specificity and 78.1% accuracy were reached with MSC, whereas 83.7% sensitivity, 84.3% specificity and 84.0% accuracy were obtained with cross-ApEn. Our results suggest that the use of nonlinear measures of synchrony could provide essential information from oximetry signals, which cannot be obtained with classical spectral analysis.},
 bibtype = {article},
 author = {Alvarez, D and Hornero, R and Abásolo, D and del Campo, F and Zamarrón, C and López, M},
 journal = {Physiological measurement},
 number = {9}
}

Paper  doi  abstract   bibtex   

@article{hirvikoski_high_2009,
	title = {High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with {ADHD} (attention-deficit/hyperactivity disorder).},
	volume = {55},
	issn = {1095-6867},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19162030},
	doi = {10.1016/j.yhbeh.2008.12.004},
	abstract = {Attention-deficit/hyperactivity disorder (ADHD) in adults is associated with significant impairment in many life activities and may thus increase the risk of chronic stress in everyday life. We compared adults with a DSM-IV ADHD diagnosis (n=28) with healthy controls (n=28) regarding subjective stress and amounts of stressors in everyday life, diurnal salivary cortisol in the everyday environment and salivary cortisol before and after cognitive stress in a laboratory setting. The association between cortisol concentrations and impulsivity was also investigated. Consistent with assumptions, individuals with ADHD reported significantly more self-perceived stress than controls, and subjective stress correlated with the amount of stressors in everyday life. The two groups were comparable with respect to overall diurnal cortisol levels and rhythm, as well as in pre- and post-stress cortisol concentrations. Post-stress cortisol (but not baseline cortisol) concentration was positively correlated with impulsivity. The group with high post-stress cortisol also reported more symptoms of depression and anxiety, as well as self-perceived stress and stressors in every-day life. The diagnosis of ADHD significantly increased the risk of belonging to the group with high post-stress cortisol levels. The results in this study warrant a focus not only on the primary diagnosis of ADHD, but also calls for a broader assessment of stressors and subjective stress in everyday life, as well as support comprising stress management and coping skills.},
	number = {3},
	urldate = {2014-05-26},
	journal = {Hormones and behavior},
	author = {Hirvikoski, Tatja and Lindholm, Torun and Nordenström, Anna and Nordström, Anna-Lena and Lajic, Svetlana},
	month = mar,
	year = {2009},
	pmid = {19162030},
	keywords = {Adolescent, Adult, Anxiety, Anxiety: psychology, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: met, Attention Deficit Disorder with Hyperactivity: psy, Circadian Rhythm, Circadian Rhythm: physiology, Depression, Depression: psychology, Female, Humans, Hydrocortisone, Hydrocortisone: metabolism, Impulsive Behavior, Impulsive Behavior: psychology, Life Change Events, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Self Concept, Socioeconomic Factors, Stress, Psychological, Stress, Psychological: metabolism, Stress, Psychological: psychology, Young Adult},
	pages = {418--24},
}

Paper  Website  abstract   bibtex   

@article{
 title = {A new tool for assessing human movement: the Kinematic Assessment Tool.},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Adult,Biomechanical Phenomena,Computers,Hand,Humans,Motor Activity,Movement,Signal Processing, Computer-Assisted,Software,Task Performance and Analysis,Time Factors,Young Adult},
 pages = {184-92},
 volume = {184},
 websites = {http://www.sciencedirect.com/science/article/pii/S016502700900404X},
 month = {10},
 day = {30},
 id = {600e7210-e036-3377-96e3-b28cb73804c7},
 created = {2016-01-20T15:47:53.000Z},
 accessed = {2016-01-20},
 file_attached = {true},
 profile_id = {d5b53108-91c5-30b8-8e6c-dd027f636bcd},
 last_modified = {2017-03-16T06:19:45.131Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 abstract = {The study of human behaviour ultimately requires the documentation of human movement. In some instances movements can be recorded through a simple button press on a computer input device. In other situations responses can be captured through questionnaire surveys. Nevertheless, there is a need within many neuroscience settings to capture how complex movements unfold over time (human kinematics). Current methods of measuring human kinematics range from accurate but multifarious laboratory configurations to portable but simplistic and time-consuming paper and pen methods. We describe a new system for recording the end-point of human movement that has the power of laboratory measures but the advantages of pen-and-paper tests: the Kinematic Assessment Tool. KAT provides a highly portable system capable of measuring human movement in configurable visual-spatial tasks. The usefulness of the system is shown in a study where 12 participants undertook a tracing and copying task using their preferred and non-preferred hand. The results show that it is possible to capture behaviour within complex tasks and quantify performance using objective measures automatically generated by the KAT system. The utility of these measures was indexed by our ability to distinguish the performance of the preferred and non-preferred hand using a single variable.},
 bibtype = {article},
 author = {Culmer, Peter R and Levesley, Martin C and Mon-Williams, Mark and Williams, Justin H G},
 journal = {Journal of neuroscience methods},
 number = {1}
}

Paper  doi  bibtex   

@article{boggio_temporal_2009,
	title = {Temporal lobe cortical electrical stimulation during the encoding and retrieval phase reduces false memories},
	volume = {4},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19319182},
	doi = {10.1371/journal.pone.0004959},
	number = {3},
	journal = {PLoS One},
	author = {Boggio, P.S. and Fregni, F. and Valasek, C. and Ellwood, S. and Chi, R. and Gallate, J. and Pascual-Leone, A. and Snyder, A.},
	year = {2009},
	keywords = {\#nosource, *Electric Stimulation, *Transcranial Magnetic Stimulation, Adolescent, Female, Humans, Learning, Male, Memory/*physiology, Temporal Lobe/*physiology, Young Adult},
	pages = {e4959},
}

@article{duncan_distinct_2009,
	title = {Distinct memory signatures in the hippocampus: intentional {States} distinguish match and mismatch enhancement signals.},
	volume = {29},
	doi = {10.1523/JNEUROSCI.2998-08.2009},
	abstract = {Incoming events that match or mismatch stored representations are thought to influence the ability of the hippocampus to switch between memory encoding and retrieval modes. Electrophysiological work has dissociated match and mismatch signals in the monkey perirhinal cortex, where match signals were selective for matches to goal states, whereas mismatch signals were not modulated by intention (Miller and Desimone, 1994). To investigate whether the theoretically important relational match and mismatch signals in the hippocampus are modulated by goal states, we fully crossed whether a probe stimulus relationally matched or mismatched a previously perceived image or goal state. Subjects performed two working memory tasks in which they either responded "yes" to probes that were identical to the previous sample scene or, after performing a relational manipulation of the scene, responded "yes" only to a probe that was identical to this perceptually novel image. Using functional magnetic resonance imaging, we found evidence for relational match enhancements bilaterally in the hippocampus that were selective for matches between the probe stimulus and goal state, but were not modulated by whether that goal was perceptually novel. Moreover, we found evidence for a complementary hippocampal mismatch enhancement that was triggered by stimuli containing salient perceptual manipulations. Our results provided evidence for parallel memory signatures in the hippocampus: a controlled match signal that can detect matches to internally generated goal states and an automatic mismatch signal that can identify unpredicted perceptual novelty.},
	language = {eng},
	number = {1},
	journal = {J Neurosci},
	author = {Duncan, Katherine and Curtis, Clayton and Davachi, Lila},
	year = {2009},
	pmid = {19129391},
	note = {Place: United States
ISBN: 1529-2401},
	keywords = {Adolescent, Adult, Analysis of Variance, Brain Mapping, Discrimination Learning, Female, Goals, Hippocampus, Humans, Image Processing, Computer-Assisted, Intention, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Oxygen, Photic Stimulation, Reaction Time, Young Adult, research support, n.i.h., extramural},
	pages = {131--139},
}

@article{hawkins_no_2009-1,
	title = {No study left behind: a network meta-analysis in non–small-cell lung cancer demonstrating the importance of considering all relevant data},
	volume = {12},
	number = {6},
	journal = {Value in health},
	author = {Hawkins, Neil and Scott, David A and Woods, Beth S and Thatcher, Nicholas},
	year = {2009},
	keywords = {80 and over, Adult, Aged, Antineoplastic Agents, Bias, Carcinoma, Data Interpretation, Docetaxel, Erlotinib Hydrochloride, Female, Humans, Lung Neoplasms, Male, Middle Aged, Non-Small-Cell Lung, oncology, Proportional Hazards Models, Protein Kinase Inhibitors, Quinazolines, Randomized Controlled Trials as Topic, Research Design, Statistical, Taxoids, Young Adult},
	pages = {996--1003},
	file = {Hawkins et al. - 2009 - No Study Left Behind A Network Meta-Analysis in N.pdf:/Users/neil.hawkins/Zotero/storage/X42T8EEQ/Hawkins et al. - 2009 - No Study Left Behind A Network Meta-Analysis in N.pdf:application/pdf},
}

@article{cohen_auditory_2009,
	title = {Auditory recognition memory is inferior to visual recognition memory.},
	volume = {106},
	doi = {10.1073/pnas.0811884106},
	abstract = {Visual memory for scenes is surprisingly robust. We wished to examine whether an analogous ability exists in the auditory domain. Participants listened to a variety of sound clips and were tested on their ability to distinguish old from new clips. Stimuli ranged from complex auditory scenes (e.g., talking in a pool hall) to isolated auditory objects (e.g., a dog barking) to music. In some conditions, additional information was provided to help participants with encoding. In every situation, however, auditory memory proved to be systematically inferior to visual memory. This suggests that there exists either a fundamental difference between auditory and visual stimuli, or, more plausibly, an asymmetry between auditory and visual processing},
	language = {eng},
	number = {14},
	journal = {Proc Natl Acad Sci U S A},
	author = {Cohen, Michael A and Horowitz, Todd S and Wolfe, Jeremy M},
	year = {2009},
	pmid = {19307569},
	note = {Place: United States
ISBN: 1091-6490},
	keywords = {Acoustic Stimulation, Adolescent, Adult, Auditory Perception, Humans, Memory, Middle Aged, Recognition (Psychology), Visual Perception, Young Adult, comparative study, research support, n.i.h., extramural, research support, u.s. gov't, non-p.h.s.},
	pages = {6008--6010},
}

Paper  doi  abstract   bibtex   

@article{ 71,
  title = {Structured variability of muscle activations supports the minimal intervention principle of motor control.},
  journal = {Journal of neurophysiology},
  volume = {102},
  year = {2009},
  month = {2009 Jul},
  pages = {59-68},
  abstract = {Numerous observations of structured motor variability indicate that the sensorimotor system preferentially controls task-relevant parameters while allowing task-irrelevant ones to fluctuate. Optimality models show that controlling a redundant musculo-skeletal system in this manner meets task demands while minimizing control effort. Although this line of inquiry has been very productive, the data are mostly behavioral with no direct physiological evidence on the level of muscle or neural activity. Furthermore, biomechanical coupling, signal-dependent noise, and alternative causes of trial-to-trial variability confound behavioral studies. Here we address those confounds and present evidence that the nervous system preferentially controls task-relevant parameters on the muscle level. We asked subjects to produce vertical fingertip force vectors of prescribed constant or time-varying magnitudes while maintaining a constant finger posture. We recorded intramuscular electromyograms (EMGs) simultaneously from all seven index finger muscles during this task. The experiment design and selective fine-wire muscle recordings allowed us to account for a median of 91% of the variance of fingertip forces given the EMG signals. By analyzing muscle coordination in the seven-dimensional EMG signal space, we find that variance-per-dimension is consistently smaller in the task-relevant subspace than in the task-irrelevant subspace. This first direct physiological evidence on the muscle level for preferential control of task-relevant parameters strongly suggest the use of a neural control strategy compatible with the principle of minimal intervention. Additionally, variance is nonnegligible in all seven dimensions, which is at odds with the view that muscle activation patterns are composed from a small number of synergies.},
  keywords = {Adolescent, Adult, Biological, Biomechanics, Electromyography, Female, Fingers, Humans, Male, Models, Movement, Muscle, Muscle Contraction, Muscle Strength, Posture, Principal Component Analysis, Psychomotor Performance, Skeletal, Time Factors, Young Adult},
  issn = {0022-3077},
  doi = {10.​1152/​jn.​90324.​2008},
  url = {http://jn.physiology.org/content/102/1/59.long},
  author = {Valero-Cuevas, Francisco J and Venkadesan, Madhusudhan and Todorov, Emanuel}
}

@article{sundstrom_risk_2009,
	title = {The risk of venous thromboembolism associated with the use of tranexamic acid and other drugs used to treat menorrhagia: a case-control study using the {General} {Practice} {Research} {Database}},
	volume = {116},
	issn = {1471-0528},
	shorttitle = {The risk of venous thromboembolism associated with the use of tranexamic acid and other drugs used to treat menorrhagia},
	doi = {10.1111/j.1471-0528.2008.01926.x},
	abstract = {OBJECTIVE: To assess whether use of tranexamic acid is associated with an increased risk of venous thromboembolism (VTE).
DESIGN: Nested case-control study.
SETTING: Database study using the General Practice Research Database for the years 1992-1998.
POPULATION: Women aged 15-49 years with a diagnosis of menorrhagia.
METHODS: Multivariate conditional logistic regression was used to estimate the risk for VTE associated with different drug treatments for menorrhagia, adjusting for confounders.
MAIN OUTCOME MEASURES: Adjusted odds ratios with 95\% CI.
RESULTS: A total of 134 cases of VTE and 552 matched controls were identified. Recent use of tranexamic acid was scarce, yielding an adjusted odds ratio for VTE of 3.20 (95\% CI 0.65-15.78). The use of mefenamic acid (ORadj 5.54 [95\% CI 2.13-14.40]) or norethisterone (ORadj 2.41 [95\% CI 1.00-5.78]) was associated with an increased risk of VTE, as was a recent--in relation to menorrhagia--diagnosis of anaemia or a haemoglobin value {\textless}11.5 g/dl (ORadj 2.23 [95\% CI 1.02-4.86]).
CONCLUSIONS: We found that tranexamic acid was associated with an increased risk of VTE, although the risk estimate did not reach statistical significance. Increased risks of VTE associated with other treatments for menorrhagia were observed. The increased risk of VTE observed with a diagnosis of anaemia--a proxy for more severe menorrhagia--suggests that menorrhagia could be a prothrombotic condition. The observed association between VTE, tranexamic acid and other treatments for menorrhagia may thus partly be explained by confounding by indication. The possibility that menorrhagia is itself a risk factor for VTE merits further investigation.},
	language = {eng},
	number = {1},
	journal = {BJOG: an international journal of obstetrics and gynaecology},
	author = {Sundström, A. and Seaman, H. and Kieler, H. and Alfredsson, L.},
	month = jan,
	year = {2009},
	pmid = {19016686},
	keywords = {Adolescent, Adult, Anemia, Iron-Deficiency, Antifibrinolytic Agents, Databases, Factual, Epidemiologic Methods, Family Practice, Female, Humans, Menorrhagia, Middle Aged, Tranexamic Acid, Venous Thromboembolism, Young Adult},
	pages = {91--97}
}

Paper  doi  bibtex   

@article{coquart_jbj_influence_2009,
title = {Influence of successive bouts of fatiguing exercise on perceptual and physiological markers during an incremental exercise test},
volume = {46},
issn = {0048-5772},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18823413},
DOI = {10.1111/j.1469-8986.2008.00717.x},
Language = {English},
Journal = {Psychophysiology},
author = {{Coquart JBJ} and {Legrand R} and {Robin S} and {Duhamel A} and {Matran R} and {Garcin M}},
year = {2009},
keywords = {Bicycling/physiology, Exercise/physiology*, Exercise Test, Heart Rate/physiology, Humans, Male, Muscle Fatigue/physiology*, Perception/physiology*, Young Adult},
pages = {209-216}
}

Paper  doi  abstract   bibtex   

@article{Hadjikhani2008a,
	title = {Pointing with the eyes: the role of gaze in communicating danger.},
	volume = {68},
	issn = {1090-2147},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2582139&tool=pmcentrez&rendertype=abstract},
	doi = {10.1016/j.bandc.2008.01.008},
	abstract = {Facial expression and direction of gaze are two important sources of social information, and what message each conveys may ultimately depend on how the respective information interacts in the eye of the perceiver. Direct gaze signals an interaction with the observer but averted gaze amounts to "pointing with the eyes", and in combination with a fearful facial expression may signal the presence of environmental danger. We used fMRI to examine how gaze direction influences brain processing of facial expression of fear. The combination of fearful faces and averted gazes activated areas related to gaze shifting (STS, IPS) and fear-processing (amygdala, hypothalamus, pallidum). Additional modulation of activation was observed in motion detection areas, in premotor areas and in the somatosensory cortex, bilaterally. Our results indicate that the direction of gaze prompts a process whereby the brain combines the meaning of the facial expression with the information provided by gaze direction, and in the process computes the behavioral implications for the observer.},
	number = {1},
	urldate = {2013-08-25},
	journal = {Brain and cognition},
	author = {Hadjikhani, Nouchine and Hoge, Rick and Snyder, Josh and de Gelder, Beatrice},
	month = oct,
	year = {2008},
	pmid = {18586370},
	keywords = {\#nosource, Adult, Amygdala, Amygdala: physiology, Analysis of Variance, Brain, Brain: physiology, Cerebral Cortex, Cerebral Cortex: physiology, Dominance, Cerebral, Dominance, Cerebral: physiology, Facial Expression, Fear, Fear: physiology, Female, Fixation, Ocular, Humans, Hypothalamus, Hypothalamus: physiology, Image Processing, Computer-Assisted, Image Processing, Computer-Assisted: methods, Magnetic Resonance Imaging, Magnetic Resonance Imaging: methods, Male, Pattern Recognition, Visual, Pattern Recognition, Visual: physiology, Photic Stimulation, Photic Stimulation: methods, Social Perception, Somatosensory Cortex, Somatosensory Cortex: physiology, Visual Perception, Visual Perception: physiology, Young Adult, cognitiva, humanos},
	pages = {1--8},
}

@article{morentin_follow-up_2008,
	title = {A follow-up investigation on the quality of medical documents from examinations of {Basque} incommunicado detainees: the role of the medical doctors and national and international authorities in the prevention of ill-treatment and torture},
	volume = {182},
	issn = {1872-6283},
	shorttitle = {A follow-up investigation on the quality of medical documents from examinations of {Basque} incommunicado detainees},
	doi = {10.1016/j.forsciint.2008.10.002},
	abstract = {According to the United Nations and the European Committee for the Prevention of Torture (CPT), torture and ill-treatment continues to be a problem during incommunicado detentions in Spain. CPT has visited Spain and published recommendations for improvements of preventive medical examinations. However, no scientific assessment of the impact of such recommendations exists. The objectives of this study were to assess the quality of documents from preventive medical examinations and the prevalence of alleged ill-treatment and compare findings with similar data from a previous study. Documents issued by state employed doctors describing medical examination of Basques held incommunicado during 2000-2005 were reviewed. The analysis covered allegations of ill-treatment and existence and quality of information essential for medical appraisal of allegations of ill-treatment. The material was collected by a non-governmental organisation. Of 425 documents concerning 118 persons, 85\% had no formal structure and the format recommended by CPT was never used. None of 127 documents, concerning 70 persons with allegations of ill-treatment had an overall conclusion on the likelihood of ill-treatment. Twelve to 68\% of necessary data were totally missing, and only 13-38\% of existing information was sufficient. There was significant variation between the reporting of individual doctors, but in general the quality was unacceptable, although somewhat higher than in the previous study. The prevalence of allegations of ill-treatment was as high as previously. There were more reports of psychological ill-treatment and procedures of forced physical exhaustion, but fewer reports of beatings. In conclusion, there was no indication that the conditions of incommunicado detainees have improved substantially over the past 15 years and the standard of medical reporting was unacceptable. The Spanish authorities should give clear objectives and guidelines for medical examinations of detainees. An independent forensic specialist with the overall academic responsibility for preventive medical examinations of detainees should be employed to supervise state employed doctors. The present article shows the necessity for harmonization of medical practice in documentation of torture.},
	language = {eng},
	number = {1-3},
	journal = {Forensic Science International},
	author = {Morentin, Benito and Petersen, Hans D. and Callado, Luis F. and Idoyaga, M. Itxaso and Meana, J. Javier},
	month = nov,
	year = {2008},
	pmid = {18995973},
	keywords = {Adult, Documentation, Female, Follow-Up Studies, Forensic Medicine, Humans, Male, Medical Records, Middle Aged, Physical Examination, Prisoners, Quality Control, Spain, Torture, Young Adult, \_tablet},
	pages = {57--65}
}

@article{reason_errors_1990,
	title = {Errors and violations on the roads: a real distinction?},
	volume = {33},
	issn = {0014-0139},
	doi = {10.1080/00140139008925335},
	abstract = {In considering the human contribution to accidents, it seems necessary to make a distinction between errors and violations},
	number = {10-11},
	journal = {Ergonomics},
	author = {REASON, JAMES and MANSTEAD, ANTONY and STRADLING, STEPHEN and BAXTER, JAMES and CAMPBELL, KAREN},
	year = {1990},
	note = {Place: England
Publisher: England: Taylor \& Francis Group},
	keywords = {Accidents, Traffic, Accidents, Traffic - psychology, Adult, Age Factors, Automobile Driving, Automobile Driving - psychology, Dangerous Behavior, Driver behaviour, Error, Female, Humans, Lapse, Male, Middle Aged, Risk-Taking, Sex Factors, Slip, Space life sciences, Surveys and Questionnaires, Violation, Young Adult},
	pages = {1315--1332},
}

@article{ senkowski_gamma-band_2009,
  title = {Gamma-band activity reflects multisensory matching in working memory},
  volume = {198},
  issn = {1432-1106},
  doi = {10.1007/s00221-009-1835-0},
  abstract = {In real-world situations, the integration of sensory information in working memory ({WM}) is an important mechanism for the recognition of objects. Studies in single sensory modalities show that object recognition is facilitated if bottom-up inputs match a template held in {WM}, and that this effect may be linked to enhanced synchronization of neurons in the gamma-band ({\textgreater}30 Hz). Natural objects, however, frequently provide inputs to multiple sensory modalities. In this {EEG} study, we examined the integration of semantically matching or non-matching visual and auditory inputs using a delayed visual-to-auditory object-matching paradigm. In the event-related potentials ({ERPs}) triggered by auditory inputs, effects of semantic matching were observed after 120-170 ms at frontal and posterior regions, indicating {WM}-specific processing across modalities, and after 250-400 ms over medial-central regions, possibly reflecting the contextual integration of sensory inputs. Additionally, total gamma-band activity ({GBA}) with medial-central topography after 120-180 ms was larger for matching compared to non-matching trials. This demonstrates that multisensory matching in {WM} is reflected by {GBA} and that dynamic coupling of neural populations in this frequency range might be a crucial mechanism for integrative multisensory processes.},
  pages = {363--372},
  number = {2},
  journaltitle = {Experimental Brain Research},
  shortjournal = {Exp Brain Res},
  author = {Senkowski, Daniel and Schneider, Till R. and Tandler, Frithjof and Engel, Andreas K.},
  date = {2009-09},
  note = {00016 {PMID}: 19458939},
  keywords = {Acoustic Stimulation, Adult, Analysis of Variance, Auditory Perception, brain, Brain mapping, electroencephalography, Evoked Potentials, Female, Humans, Male, Memory, Short-Term, Neuropsychological Tests, Photic Stimulation, Reaction Time, Time Factors, Visual Perception, Young Adult},
  file = {Senkowski et al_2009_Experimental Brain Research_Gamma-band activity reflects multisensory matching in working memory.pdf:files/1296/Senkowski et al_2009_Experimental Brain Research_Gamma-band activity reflects multisensory matching in working memory.pdf:application/pdf}
}