@article{blommaert_expression_2019,
	title = {Expression, localization, and concentration of {A}-kinase anchor protein 4 ({AKAP4}) and its precursor ({proAKAP4}) in equine semen: {Promising} marker correlated to the total and progressive motility in thawed spermatozoa},
	volume = {131},
	issn = {1879-3231},
	shorttitle = {Expression, localization, and concentration of {A}-kinase anchor protein 4 ({AKAP4}) and its precursor ({proAKAP4}) in equine semen},
	doi = {10.1016/j.theriogenology.2019.03.011},
	abstract = {A-kinase anchor protein 4 (AKAP4) is playing a central role in flagellar structure, chemotaxis, capacitation and sperm motility. In mammals, AKAP4 is expressed during spermatogenesis. AKAP4 is synthesized as a precursor, proAKAP4, which is cleaved into mature AKAP4 during fibrous sheath assembly. The proAKAP4 is a good indicator of sperm quality in humans and boars. The aims of this work were to study the expression, the localization and the concentration of proAKAP4 and AKAP4 in equine semen, and to evaluate the possible correlation between the total and progressive motility and the concentration of proAKAP4 measured by ELISA in post-thawed semen. Frozen sperm from 13 different stallions were used. Semen samples (n = 17) were prepared using the INRA Freeze medium to reach a concentration of 150 million spermatozoa/mL, packaged and frozen in 0.5 mL straws. The precursor proAKAP4 and the mature protein AKAP4 both localize to the fibrous sheath of the principle piece of equine sperm flagellum. The concentrations of proAKAP4 were determined in the post-thawed semen using ELISA method (Horse 4MID® kits, 4BioDx, France). The mean concentration of proAKAP4 was then of 7.372 ± 0.79 ng/μL and was significantly correlated with the post-thawed total motility (Pearson coefficient r = 0.66, p = 0.002) and progressive motility (Pearson coefficient r = 0.76, p = 0.0002) and the amount of proAKAP4 represent the amount of spermatozoa that expressed proAKAP4. Taken together, these preliminary results confirm the interest to use proAKAP4 concentrations as a promising marker of stallion sperm quality as close correlation was observed between the proAKAP4 concentration and sperm motility parameters.},
	language = {eng},
	journal = {Theriogenology},
	author = {Blommaert, D. and Sergeant, N. and Delehedde, M. and Jouy, N. and Mitchell, V. and Franck, T. and Donnay, I. and Lejeune, J. P. and Serteyn, D.},
	month = jun,
	year = {2019},
	pmid = {30947075},
	keywords = {Biomarkers, Animals, A Kinase Anchor Proteins, AKAP4, Cryopreservation, Horse, Horses, Progressive motility, Semen, Semen analysis, Sperm Motility},
	pages = {52--60}
}

@article{raina_gelatin-_2018,
	title = {Gelatin- hydroxyapatite- calcium sulphate based biomaterial for long term sustained delivery of bone morphogenic protein-2 and zoledronic acid for increased bone formation: {In}-vitro and in-vivo carrier properties},
	volume = {272},
	issn = {1873-4995},
	doi = {10.1016/j.jconrel.2018.01.006},
	abstract = {In this study, a novel macroporous composite biomaterial consisting of gelatin-hydroxyapatite-calcium sulphate for delivery of bone morphogenic protein-2 (rhBMP-2) and zoledronic acid (ZA) has been developed. The biomaterial scaffold has a porous structure and functionalization of the scaffold with rhBMP-2 induces osteogenic differentiation of MC3T3-e1 cells seen by a significant increase in biochemical and genetic markers of osteoblastic differentiation. In-vivo muscle pouch experiments showed higher mineralization using scaffold+rhBMP-2 when compared to an approved absorbable collagen sponge (ACS)+rhBMP-2 as verified by micro-CT. Co-delivery of rhBMP-2+ZA via the novel scaffold enabled a reduction in the effective rhBMP-2 doses. The presence of tartrate resistant acid phosphatase staining in the rhBMP-2 group indicates osteoclastic resorption, which could be stalled by adding ZA, which by speculation could explain the net increase in mineralization. The new scaffold allowed for slow release of rhBMP-2 in-vitro (3.3±0.1\%) after 4weeks. Using single photon emission computed tomography (SPECT), the release kinetics of 125I-rhBMP-2 in-vivo was followed for 4weeks and a total of 65.3±15.2\% 125I-rhBMP-2 was released from the scaffolds. In-vitro 14C-ZA release curve shows an initial burst release on day 1 (8.8±0.7\%) followed by a slow release during the following 4weeks (13±0.1\%). In-vivo, an initial release of 43.2±7.6\% of 14C-ZA was detected after 1day, after which the scaffold retained the remaining ZA during 4-weeks. Taken together, our results show that the developed biomaterial is an efficient carrier for spatio-temporal delivery of rhBMP-2 and ZA leading to increased bone formation compared to commercially available carrier for rhBMP-2.},
	language = {eng},
	journal = {Journal of Controlled Release: Official Journal of the Controlled Release Society},
	author = {Raina, Deepak Bushan and Larsson, David and Mrkonjic, Filip and Isaksson, Hanna and Kumar, Ashok and Lidgren, Lars and Tägil, Magnus},
	year = {2018},
	pmid = {29329716},
	keywords = {Animals, Biocompatible Materials, Bone Density Conservation Agents, Bone Morphogenetic Protein 2, Bone morphogenic protein (BMP), Calcium Sulfate, Cell Line, Cell Survival, Cryogels, Delayed-Action Preparations, Durapatite, Gelatin, Hydroxyapatite, In-vivo BMP release, In-vivo ZA release, Male, Mice, Osteogenesis, Rats, Sprague-Dawley, Recombinant Proteins, Transforming Growth Factor beta, Zoledronic Acid, Zoledronic acid (ZA)},
	pages = {83--96},
}

@article{dulamea_role_2017,
	title = {Role of {Oligodendrocyte} {Dysfunction} in {Demyelination}, {Remyelination} and {Neurodegeneration} in {Multiple} {Sclerosis}},
	volume = {958},
	issn = {0065-2598},
	doi = {10.1007/978-3-319-47861-6_7},
	abstract = {Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during development and throughout adulthood. They result from a complex and well controlled process of activation, proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPCs) from the germinative niches of the CNS. In multiple sclerosis (MS), the complex pathological process produces dysfunction and apoptosis of OLs leading to demyelination and neurodegeneration. This review attempts to describe the patterns of demyelination in MS, the steps involved in oligodendrogenesis and myelination in healthy CNS, the different pathways leading to OLs and myelin loss in MS, as well as principles involved in restoration of myelin sheaths. Environmental factors and their impact on OLs and pathological mechanisms of MS are also discussed. Finally, we will present evidence about the potential therapeutic targets in re-myelination processes that can be accessed in order to develop regenerative therapies for MS.},
	language = {eng},
	journal = {Advances in Experimental Medicine and Biology},
	author = {Dulamea, Adriana Octaviana},
	year = {2017},
	pmid = {28093710},
	keywords = {Animals, Demyelinating Diseases, Demyelination, Humans, Multiple Sclerosis, Multiple sclerosis, Myelin Sheath, Nerve Degeneration, Nerve Regeneration, Neural Stem Cells, Neurodegeneration, Neurogenesis, Oligodendrocyte, Oligodendrocyte progenitor cell, Oligodendroglia, Re-myelination},
	pages = {91--127},
}

@article{van_dung_large-scale_2016,
	title = {Large-scale screening and characterization of enteroviruses and kobuviruses infecting pigs in {Vietnam}.},
	volume = {97},
	issn = {1465-2099 0022-1317},
	doi = {10.1099/jgv.0.000366},
	abstract = {A recent survey of pigs in Dong Thap province, Vietnam identified a high frequency of enterovirus species G (EV-G) infection (144/198; 72.7\%). Amongst these was a plethora of EV-G types (EV-G1, EV-G6 and four new types},
	language = {eng},
	number = {2},
	journal = {The Journal of general virology},
	author = {Van Dung, Nguyen and Anh, Pham Hong and Van Cuong, Nguyen and Hoa, Ngo Thi and Carrique-Mas, Juan and Hien, Vo Be and Sharp, C. and Rabaa, M. and Berto, A. and Campbell, James and Baker, Stephen and Farrar, Jeremy and Woolhouse, Mark E. and Bryant, Juliet E. and Simmonds, Peter},
	month = feb,
	year = {2016},
	pmid = {26653281},
	pmcid = {PMC5115164},
	keywords = {Animals, Diarrhea/epidemiology/veterinary/virology, Enterovirus Infections/epidemiology/*veterinary/virology, Enterovirus/classification/genetics/*isolation \& purification, Feces/*virology, Genetic Variation, Kobuvirus/classification/genetics/*isolation \& purification, Mass Screening, Picornaviridae Infections/epidemiology/*veterinary/virology, Prevalence, Sus scrofa, Swine, Swine Diseases/*epidemiology/*virology, Vietnam/epidemiology, Viral Load},
	pages = {378--388},
}

@article{
 title = {Reticulate evolutionary history and extensive introgression in mosquito species revealed by phylogenetic network analysis.},
 type = {article},
 year = {2016},
 identifiers = {[object Object]},
 keywords = {Animals,Culicidae,Evolution, Molecular,Genome, Insect,Hybridization, Genetic,Models, Genetic,Phylogeny,genetics},
 pages = {2361-2372},
 volume = {25},
 month = {6},
 id = {4969f961-914c-3873-8586-ae1ca0c7c0e9},
 created = {2017-09-07T16:35:51.015Z},
 file_attached = {false},
 profile_id = {5db6d3e7-562f-3ec2-a249-16ecf1e747e4},
 group_id = {49665d18-5720-3154-b3f7-40652b55b7b9},
 last_modified = {2017-09-15T13:46:36.898Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Wen2016},
 source_type = {Journal Article},
 language = {eng},
 country = {England},
 patent_owner = {NLM},
 folder_uuids = {213ba69b-866b-4785-8816-8fc333e9477c},
 private_publication = {false},
 abstract = {The role of hybridization and subsequent introgression has been demonstrated in an increasing number of species. Recently, Fontaine et al. (Science, 347, 2015, 1258524) conducted a phylogenomic analysis of six members of the Anopheles gambiae species complex. Their analysis revealed a reticulate evolutionary history and pointed to extensive introgression on all four autosomal arms. The study further highlighted the complex evolutionary signals that the co-occurrence of incomplete lineage sorting (ILS) and introgression can give rise to in phylogenomic analyses. While tree-based methodologies were used in the study, phylogenetic networks provide a more natural model to capture reticulate evolutionary histories. In this work, we reanalyse the Anopheles data using a recently devised framework that combines the multispecies coalescent with phylogenetic networks. This framework allows us to capture ILS and introgression simultaneously, and forms the basis for statistical methods for inferring reticulate evolutionary histories. The new analysis reveals a phylogenetic network with multiple hybridization events, some of which differ from those reported in the original study. To elucidate the extent and patterns of introgression across the genome, we devise a new method that quantifies the use of reticulation branches in the phylogenetic network by each genomic region. Applying the method to the mosquito data set reveals the evolutionary history of all the chromosomes. This study highlights the utility of 'network thinking' and the new insights it can uncover, in particular in phylogenomic analyses of large data sets with extensive gene tree incongruence.},
 bibtype = {article},
 author = {Wen, Dingqiao and Yu, Yun and Hahn, Matthew W and Nakhleh, Luay},
 journal = {Molecular ecology},
 number = {11}
}

@article{li_comparison_2016,
	title = {Comparison of liver {microRNA} transcriptomes of {Tibetan} and {Yorkshire} pigs by deep sequencing},
	volume = {577},
	issn = {1879-0038},
	doi = {10.1016/j.gene.2015.12.003},
	abstract = {MicroRNAs (miRNAs) play an important role in the modulation of various metabolic processes in the liver, yet little is known about the liver microRNAome (miRNAome) of the Tibetan pig. Here we used the Yorkshire pig as a control to analyze the Tibetan pig-specific liver miRNAome, and for preliminary investigation of differentially expressed miRNAs participating in metabolism. A comprehensive analysis of Tibetan and Yorkshire pig liver miRNAomes by small RNA sequencing identified 362 unique miRNAs. Among these, 304 were co-expressed in both libraries, and 10 and 48 miRNAs were specifically expressed. Differential expression analysis of miRNAs, miRNA target prediction and KEGG analysis revealed that differentially expressed miRNAs were associated mainly with the metabolism of glucose, lipid and protein. Six differentially expressed miRNAs (miR-34a, miR-326, miR-1, miR-335, miR-185 and miR-378) participating in the metabolism of glucose and lipid were identified. Additionally, qPCR results revealed that a lower expression of miR-34a in Tibetan pig liver may promote gluconeogenesis by increasing the expression of Sirtuin type 1 (Sirt1); a lower expression of miR-1 in Tibetan pig liver may promote the synthesis and accumulation of lipid by increasing the expression of Liver X receptor α (LXRα); and a lower expression of miR-185 in Tibetan pig liver may promote the uptake of cholesterol from blood and secretion of bile by increasing the expression of the scavenger receptor class B type I (SR-BI). Our results provide new information and understanding of porcine miRNA profiles, which may help explain the regulatory mechanisms of miRNAs in the metabolic functions of Tibetan pig liver, and provide new biomarkers to assist in the development of Tibetan pig breeding characteristics.},
	language = {eng},
	number = {2},
	journal = {Gene},
	author = {Li, Yanyue and Li, Xiaocheng and Sun, Wen-Kui and Cheng, Chi and Chen, Yi-Hui and Zeng, Kai and Chen, Xiaohui and Gu, Yiren and Gao, Rong and Liu, Rui and Lv, Xuebin},
	month = feb,
	year = {2016},
	pmid = {26656174},
	keywords = {Animals, Base Sequence, Liver, MiRNAome, MiRNAs, MicroRNAs, Molecular Sequence Data, Sequence Alignment, Sus scrofa, Tibetan pig, Transcriptome, Yorkshire pig},
	pages = {244--250},
}

@article{irwin_tauopathies_2016,
	title = {Tauopathies as clinicopathological entities},
	volume = {22 Suppl 1},
	issn = {1873-5126},
	doi = {10.1016/j.parkreldis.2015.09.020},
	abstract = {Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial inclusions composed of the microtubule-binding protein, tau. Several lines of evidence suggest tau aggregation is central to the neurodegenerative process in tauopathies. First, recent animal and cell model studies find abnormally-modified tau alone may be transmitted between adjacent neurons and spread to anatomically connected brain regions to recapitulate human disease. Further, staging efforts in human autopsy cases suggest a sequential distribution of tau aggregation in the central nervous system that could reflect this observed cell-to-cell transmission of pathogenic tau species in animal models. Finally, pathogenic mutations in the MAPT gene encoding tau protein cause hereditary forms of tauopathy. Clinically, tauopathies can present with a range of phenotypes that include both movement- and cognitive/behavioral-disorders (i.e. frontotemporal dementia spectrum disorders) or non-specific amnestic symptoms in advanced age. A major limitation is that current clinical diagnostic criteria for these disorders do not reliably differentiate underlying tauopathy from other neurodegenerative diseases, such as TDP-43 proteinopathies. Thus, current research efforts are focused on improving the ante mortem diagnosis of tauopathies, including pre-clinical stages of disease, as many therapeutic strategies for emerging disease-modifying therapies focus on preventing abnormal folding and spread of tau pathology.},
	language = {eng},
	journal = {Parkinsonism \& Related Disorders},
	author = {Irwin, David J.},
	month = jan,
	year = {2016},
	pmid = {26382841},
	pmcid = {PMC4662611},
	keywords = {Animals, Argyrophilic grain disease, Brain, Corticobasal degeneration, Corticobasal syndrome tauopathy, DNA-Binding Proteins, Frontotemporal dementia, Frontotemporal lobar degeneration, Humans, MAPT mutation, Neurodegenerative Diseases, Pick Disease of the Brain, Pick's disease, Primary age related tauopathy, Primary progressive aphasia, Progressive supranuclear palsy, Tauopathies, tau Proteins},
	pages = {S29--33},
}

Paper  doi  abstract   bibtex   1 download  

@article{felten_vibrational_2015,
	title = {Vibrational spectroscopic image analysis of biological material using multivariate curve resolution-alternating least squares ({MCR}-{ALS})},
	volume = {10},
	issn = {1750-2799 (Electronic) 1750-2799 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/25569330},
	doi = {10.1038/nprot.2015.008},
	abstract = {Raman and Fourier transform IR (FTIR) microspectroscopic images of biological material (tissue sections) contain detailed information about their chemical composition. The challenge lies in identifying changes in chemical composition, as well as locating and assigning these changes to different conditions (pathology, anatomy, environmental or genetic factors). Multivariate data analysis techniques are ideal for decrypting such information from the data. This protocol provides a user-friendly pipeline and graphical user interface (GUI) for data pre-processing and unmixing of pixel spectra into their contributing pure components by multivariate curve resolution-alternating least squares (MCR-ALS) analysis. The analysis considers the full spectral profile in order to identify the chemical compounds and to visualize their distribution across the sample to categorize chemically distinct areas. Results are rapidly achieved (usually {\textless}30-60 min per image), and they are easy to interpret and evaluate both in terms of chemistry and biology, making the method generally more powerful than principal component analysis (PCA) or heat maps of single-band intensities. In addition, chemical and biological evaluation of the results by means of reference matching and segmentation maps (based on k-means clustering) is possible.},
	language = {en},
	number = {2},
	urldate = {2021-06-07},
	journal = {Nat Protoc},
	author = {Felten, J. and Hall, H. and Jaumot, J. and Tauler, R. and de Juan, A. and Gorzsas, A.},
	month = feb,
	year = {2015},
	note = {Edition: 2015/01/09},
	keywords = {*Multivariate Analysis, *Spectroscopy, Fourier Transform Infrared, *Spectrum Analysis, Raman, Animals, Image Processing, Computer-Assisted/*methods, Islets of Langerhans/chemistry, Least-Squares Analysis, Mice, Inbred C57BL, Populus/chemistry, User-Computer Interface, Xylem/chemistry},
	pages = {217--40},
}

@article{tse_cruciferous_2014,
	title = {Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis},
	volume = {66},
	issn = {1532-7914},
	shorttitle = {Cruciferous vegetables and risk of colorectal neoplasms},
	doi = {10.1080/01635581.2014.852686},
	abstract = {Evidence shows cruciferous vegetables exhibit chemoprotective properties, commonly attributed to their rich source of isothiocyanates. However, epidemiological data examining the association between cruciferous vegetable intake and colorectal neoplasms have been inconclusive. This meta-analysis examines the epidemiological evidence to characterize the association between cruciferous vegetable intake and risk of developing colorectal neoplasms. Thirty-three articles were included in the meta-analysis after a literature search of electronic databases. Subgroup analysis for individual cruciferae types (n = 8 studies) and GST polymorphism (n = 8 studies) were performed. Pooled adjusted odds ratios (ORs) comparing highest and lowest categories of dietary pattern scores were calculated. Results show a statistically significant inverse association between cruciferous vegetable intake and colon cancer [OR = 0.84; 95\% confidence interval (CI): 0.72-0.98; P value heterogeneity {\textless} 0.001]. Broccoli in particular exhibited protective benefits against colorectal (CRC) neoplasms (OR = 0.80; 95\% CI: 0.65-0.99; P value heterogeneity = 0.02). Stratification by GST genotype reveals that the GSTT1 null genotype confers a reduction in CRC risk (OR = 0.78; 95\% CI: 0.64-0.95; P value heterogeneity = 0.32). This study provides support to the hypothesis that cruciferous vegetable intake protects against cancer of the colon. This study also demonstrates the significance of gene-diet interactions and the importance of assessing individual cruciferous vegetables.},
	language = {eng},
	number = {1},
	journal = {Nutrition and Cancer},
	author = {Tse, Genevieve and Eslick, Guy D.},
	year = {2014},
	pmid = {24341734},
	keywords = {Animals, Brassica, Brassicaceae, Colorectal Neoplasms, Disease Models, Animal, Feeding Behavior, Gene-Environment Interaction, Genotype, Glutathione Transferase, Humans, Observational Studies as Topic, Polymorphism, Genetic, Risk Factors, Vegetables},
	pages = {128--139},
}

Paper  doi  abstract   bibtex   

@article{Heiker-2014-ID6,
  title     = {Identification of genetic loci associated with different responses to
               high-fat diet-induced obesity in C57{BL}/6N and C57{BL}/6J substrains.},
  abstract  = {We have recently demonstrated that C57{BL}/6{NT}ac and C57{BL}/6{JR}j
               substrains are significantly different in their response to high-fat
               diet-induced obesity ({DIO}). The C57{BL}/6{JR}j substrain seems to be
               protected from {DIO} and genetic differences between C57{BL}/6J and
               C57{BL}/6N substrains at 11 single nucleotide polymorphism ({SNP}) loci
               have been identified. To define genetic variants as well as differences in
               parameters of glucose homeostasis and insulin sensitivity between
               C57{BL}/6{NT}ac and C57{BL}/6{JR}j substrains that may explain the
               different response to {DIO}, we analyzed 208 first backcross ({BC}1)
               hybrids of C57{BL}/6{NT}ac and C57{BL}/6{JR}j [(C57{BL}/6{NT}ac ×
               C57{BL}/6{JR}j)F1 × C57{BL}/6{NT}ac] mice. Body weight, epigonadal and
               subcutaneous fat mass, circulating leptin, as well as parameters of glucose
               metabolism were measured after 10 wk of high-fat diet ({HFD}). Genetic
               profiling of {BC}1 hybrids were performed using TaqMan {SNP} genotyping
               assays. Furthermore, to assess whether {SNP} polymorphisms could affect
               m{RNA} level, we carried out gene expression analysis in murine liver
               samples. Human subcutaneous adipose tissue was used to verify murine data
               of {SNAP}29. We identified four sex-specific variants that are associated
               with the extent of {HFD}-induced weight gain and fat depot mass. {BC}1
               hybrids carrying the combination of risk or beneficial alleles exhibit the
               phenotypical extremes of the parental strains. Murine and human {SC}
               expression analysis revealed Snap29 as strongest candidate. Our data
               indicate an important role of these loci in responsiveness to {HFD}-induced
               obesity and suggest genes of the synaptic vesicle release system such as
               Snap29 being involved in the regulation of high-fat {DIO}.},
  author    = {Heiker, John T and Kunath, Anne and Kosacka, Joanna and Flehmig, Gesine and
               Knigge, Anja and Kern, Matthias and Stumvoll, Michael and Kovacs, Peter and
               Blüher, Matthias and Klöting, Nora},
  volume    = {46},
  number    = {11},
  pages     = {377--84},
  year      = {2014},
  month     = {6},
  url       = {http://www.pubmed.org/24692188},
  pmid      = {24692188},
  doi       = {10.1152/physiolgenomics.00014.2014},
  keywords  = {Animals, Humans, Mice, Male, Adipose Tissue, Alleles, Body Weight, Diet,
               High-Fat, Female, Genetic Loci, Genotype, Glucose, Leptin, Mice, Inbred
               C57{BL}, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Vesicular
               Transport Proteins, Weight Gain},
  file      = {FULLTEXT:pdfs/000/000/000000006.pdf:PDF}
}

@article{gawri_link_2014,
	title = {Link {N} is cleaved by human annulus fibrosus cells generating a fragment with retained biological activity},
	volume = {32},
	issn = {1554-527X},
	doi = {10.1002/jor.22653},
	abstract = {Presently, there are no established treatments to prevent, stop or even retard back pain arising from disc degeneration. Previous studies have shown that Link N can act as a growth factor and stimulate the synthesis of proteoglycans and collagens, in IVD. However, the sequences in Link N involved in modulating cellular activity are not well understood. To determine if disc cells can proteolytically process Link N, human disc cells were exposed to native Link N over a 48 h period and mass spectrometric analysis revealed that a peptide spanning residues 1-8 was generated in the presence of AF cells but not NP cells. Link N 1-8 significantly induced proteoglycan production in the presence of IL-1β NP and AF cells, confirming that the biological effect is maintained in the first 8 amino acids of the peptide and indicating that the effect is sustained in an inflammatory environment. Thus Link-N 1-8 could be a promising candidate for biologically induced disc repair, and the identification of such a stable specific peptide may facilitate the design of compounds to promote disc repair and provide alternatives to surgical intervention for early stage disc degeneration.},
	language = {eng},
	number = {9},
	journal = {Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society},
	author = {Gawri, Rahul and Ouellet, Jean and Önnerfjord, Patrik and Alkhatib, Bashar and Steffen, Thomas and Heinegård, Dick and Roughley, Peter and Antoniou, John and Mwale, Fackson and Haglund, Lisbet},
	month = sep,
	year = {2014},
	pmid = {24861010},
	keywords = {Adolescent, Adult, Amino Acid Sequence, Animals, Biological Factors, Cattle, Cells, Cultured, Collagen, Female, Humans, IVD degeneration and regeneration, Intercellular Signaling Peptides and Proteins, Intervertebral Disc, Intervertebral Disc Degeneration, Link N, Lumbar Vertebrae, Male, Middle Aged, Molecular Sequence Data, Peptide Fragments, Proteoglycans, Regeneration, Thoracic Vertebrae, Young Adult, biological repair, organ culture},
	pages = {1189--1197},
}

Paper  doi  abstract   bibtex   

@article{chu_thermal_2014,
	title = {Thermal ablation of tumours: biological mechanisms and advances in therapy},
	volume = {14},
	copyright = {2014 Nature Publishing Group},
	issn = {1474-1768},
	shorttitle = {Thermal ablation of tumours},
	url = {https://www.nature.com/articles/nrc3672},
	doi = {10.1038/nrc3672},
	abstract = {Minimally invasive thermal ablation of tumours has become common since the advent of modern imaging. From the ablation of small, unresectable tumours to experimental therapies, percutaneous radiofrequency ablation, microwave ablation, cryoablation and irreversible electroporation have an increasing role in the treatment of solid neoplasms. This Opinion article examines the mechanisms of tumour cell death that are induced by the most common thermoablative techniques and discusses the rapidly developing areas of research in the field, including combinatorial ablation and immunotherapy, synergy with conventional chemotherapy and radiation, and the development of a new ablation modality in irreversible electroporation.},
	language = {en},
	number = {3},
	urldate = {2018-09-22},
	journal = {Nature Reviews Cancer},
	author = {Chu, Katrina F. and Dupuy, Damian E.},
	month = mar,
	year = {2014},
	note = {00506},
	keywords = {Ablation Techniques, Animals, Apoptosis, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Neoplasms, Surgery, Computer-Assisted},
	pages = {199--208},
}

@article{ kidd_influenza_2014,
  title = {Influenza viruses: update on epidemiology, clinical features, treatment and vaccination},
  volume = {20},
  issn = {1531-6971},
  shorttitle = {Influenza viruses},
  doi = {10.1097/MCP.0000000000000049},
  abstract = {PURPOSE OF REVIEW: In the last decade, sporadic and lethal human disease caused by zoonotic avian influenza viruses, and the seasonal activity of human H1N1 2009 pandemic type have driven intense epidemiological and laboratory studies into the virus life cycle. This article highlights major developments from mid-2012 to early 2014.
RECENT FINDINGS: Advances in molecular techniques and efficient rollout of diagnostic tests have enabled the rapid identification of clinical cases and detailed genetic sequencing of viral genomes. Studies have contributed widely to the understanding of how and when influenza viruses circulate, what determines their innate pathogenicity in particular hosts and whether host cofactors influence disease severity. Other imperatives include investigations into how influenza can be better prevented by vaccination, or treated with antiviral drugs.
SUMMARY: Avian influenza viruses present a continuous threat to human populations. There is a need for sustained surveillance and downstream research to evaluate the potential for future pandemics.},
  language = {eng},
  number = {3},
  journal = {Current Opinion in Pulmonary Medicine},
  author = {Kidd, Mike},
  month = {May},
  year = {2014},
  pmid = {24637227},
  keywords = {Animals, Antiviral Agents, DNA, Viral, Drug Resistance, Viral, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H7N9 Subtype, Influenza A virus, Influenza in Birds, Influenza, Human, Male, Pandemics, Poultry, Seasons, Sentinel Surveillance, Sequence Analysis, DNA, Viral Vaccines, Zanamivir},
  pages = {242--246}
}

@article{krauth_nonindustry-sponsored_2014,
	title = {Nonindustry-sponsored preclinical studies on statins yield greater efficacy estimates than industry-sponsored studies: a meta-analysis},
	volume = {12},
	issn = {1545-7885},
	shorttitle = {Nonindustry-sponsored preclinical studies on statins yield greater efficacy estimates than industry-sponsored studies},
	doi = {10.1371/journal.pbio.1001770},
	abstract = {Industry-sponsored clinical drug studies are associated with publication of outcomes that favor the sponsor, even when controlling for potential bias in the methods used. However, the influence of sponsorship bias has not been examined in preclinical animal studies. We performed a meta-analysis of preclinical statin studies to determine whether industry sponsorship is associated with either increased effect sizes of efficacy outcomes and/or risks of bias in a cohort of published preclinical statin studies. We searched Medline (January 1966-April 2012) and identified 63 studies evaluating the effects of statins on atherosclerosis outcomes in animals. Two coders independently extracted study design criteria aimed at reducing bias, results for all relevant outcomes, sponsorship source, and investigator financial ties. The I(2) statistic was used to examine heterogeneity. We calculated the standardized mean difference (SMD) for each outcome and pooled data across studies to estimate the pooled average SMD using random effects models. In a priori subgroup analyses, we assessed statin efficacy by outcome measured, sponsorship source, presence or absence of financial conflict information, use of an optimal time window for outcome assessment, accounting for all animals, inclusion criteria, blinding, and randomization. The effect of statins was significantly larger for studies sponsored by nonindustry sources (-1.99; 95\% CI -2.68, -1.31) versus studies sponsored by industry (-0.73; 95\% CI -1.00, -0.47) (p value{\textless}0.001). Statin efficacy did not differ by disclosure of financial conflict information, use of an optimal time window for outcome assessment, accounting for all animals, inclusion criteria, blinding, and randomization. Possible reasons for the differences between nonindustry- and industry-sponsored studies, such as selective reporting of outcomes, require further study.},
	language = {eng},
	number = {1},
	journal = {PLoS biology},
	author = {Krauth, David and Anglemyer, Andrew and Philipps, Rose and Bero, Lisa},
	month = jan,
	year = {2014},
	pmid = {24465178},
	pmcid = {PMC3897361},
	keywords = {8 Ignorance and funding bias, Animals, Atherosclerosis, Biais de financement, Conflict of Interest, Cost-Benefit Analysis, Dose-Response Relationship, Drug, Drug Evaluation, Preclinical, Drug Industry, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, MEDLINE, PRINTED (Fonds papier), Publication Bias, Sample Size, Treatment Outcome},
	pages = {e1001770},
}

Paper  doi  abstract   bibtex   

@article{Stewart2014,
	title = {Developing zebrafish models of autism spectrum disorder ({ASD}).},
	volume = {50},
	issn = {1878-4216},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/24315837},
	doi = {10.1016/j.pnpbp.2013.11.014},
	abstract = {Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder with complex symptoms and unclear, multi-factorial pathogenesis. Animal (rodent) models of ASD-like behavior are extensively used to study genetics, circuitry and molecular mechanisms of ASD. The evolutionarily conserved nature of social behavior and its molecular pathways suggests that alternative experimental models can be developed to complement and enhance the existing rodent ASD paradigms. The zebrafish (Danio rerio) is rapidly becoming a popular model organism in neuroscience and biological psychiatry to study brain function, model human brain disorders and explore their genetic or pharmacological modulation. Representing highly social animals, zebrafish emerge as a strong potential model organism to study normal and pathological social phenotypes, as well as several other ASD-like symptoms. Here, we discuss the developing utility of zebrafish in modeling ASD as a new emerging field in translational neuroscience and drug discovery.},
	urldate = {2016-01-07},
	journal = {Progress in neuro-psychopharmacology \& biological psychiatry},
	author = {Stewart, Adam Michael and Nguyen, Michael and Wong, Keith and Poudel, Manoj K. and Kalueff, Allan V.},
	month = apr,
	year = {2014},
	pmid = {24315837},
	note = {ISBN: 1878-4216 (Electronic){\textbackslash}r0278-5846 (Linking)},
	keywords = {\#nosource, Animal, Animals, Brain, Brain: physiology, Child Development Disorders, Disease Models, Humans, Pervasive, Pervasive: chemically, Pervasive: genetics, Pervasive: physiopath, Pervasive: psychology, Social Behavior, Zebrafish, disorders, zebrafish},
	pages = {27--36},
}

@article{chiang_vitro_2013,
	title = {In vitro and in vivo evaluation of amorphous solid dispersions generated by different bench-scale processes, using griseofulvin as a model compound},
	volume = {15},
	issn = {1550-7416 (Electronic) 1550-7416 (Linking)},
	doi = {10.1208/s12248-013-9469-3},
	abstract = {Drug polymer-based amorphous solid dispersions (ASD) are widely used in the pharmaceutical industry to improve bioavailability for poorly water-soluble compounds. Spray-drying is the most common process involved in the manufacturing of ASD material. However, spray-drying involves a high investment of material quantity and time. Lower investment manufacturing processes such as fast evaporation and freeze-drying (lyophilization) have been developed to manufacture ASD at the bench level. The general belief is that the overall performance of ASD material is thermodynamically driven and should be independent of the manufacturing process. However, no formal comparison has been made to assess the in vivo performance of material generated by different processes. This study compares the in vitro and in vivo properties of ASD material generated by fast evaporation, lyophilization, and spray-drying methods using griseofulvin as a model compound and hydroxypropyl methylcellulose acetate succinate as the polymer matrix. Our data suggest that despite minor differences in the formulation release properties and stability of the ASD materials, the overall exposure is comparable between the three manufacturing processes under the conditions examined. These results suggest that fast evaporation and lyophilization may be suitable to generate ASD material for oral evaluation. However, caution should be exercised since the general applicability of the present findings will need to be further evaluated.},
	number = {2},
	journal = {AAPS J},
	author = {Chiang, P. C. and Cui, Y. and Ran, Y. and Lubach, J. and Chou, K. J. and Bao, L. and Jia, W. and La, H. and Hau, J. and Sambrone, A. and Qin, A. and Deng, Y. and Wong, H.},
	month = apr,
	year = {2013},
	pmcid = {PMC3675757},
	keywords = {Administration, Oral, Animals, Biological Availability, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Crystallography, X-Ray, Drug Compounding, Drug Stability, Freeze Drying, Griseofulvin/administration \& dosage/*chemistry/pharmacokinetics, Magnetic Resonance Spectroscopy, Male, Methylcellulose/*analogs \& derivatives/chemistry, Powder Diffraction, Rats, Rats, Sprague-Dawley, Solubility, Technology, Pharmaceutical/*methods, Thermogravimetry},
	pages = {608--17},
}

Paper  doi  abstract   bibtex   

@article{heredia_behavioral_2012,
	title = {Behavioral effects of oral subacute exposure to {BDE}-209 in young adult mice: a preliminary study.},
	volume = {50},
	issn = {1873-6351},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22178224},
	doi = {10.1016/j.fct.2011.12.002},
	abstract = {In this study, we examined the effects of an oral subacute exposure to 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209) on young adult inbred wild type Tg2576 mice. BDE-209 was administered by gavage at doses of 0 and 20 mg/kg/day dissolved in sunflower oil for 15 days. Two behavioral endpoints were examined: anxiety-activity in a light/dark test and a zero maze test, and learning and spatial memory in a water maze test. Young adult mice exposed to BDE-209 showed a reduction in anxiety levels and a delayed learning in a spatial memory task. Although the results indicated that behavioral effects were present in a young adult exposed population of wild type Tg2576 mice, further studies on chronic exposure to BDE-209 are clearly necessary in order to corroborate these effects.},
	number = {3-4},
	journal = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
	author = {Heredia, Luis and Torrente, Margarita and Colomina, María T and Domingo, José L},
	month = mar,
	year = {2012},
	pmid = {22178224},
	keywords = {Administration, Animal, Animal: drug effects, Animals, Behavior, Body Weight, Body Weight: drug effects, Darkness, Dose-Response Relationship, Drug, Flame Retardants: pharmacology, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: pharmacology, Light, Male, Maze Learning, Mice, Oral, Transgenic},
	pages = {707--12},
}

Paper  abstract   bibtex   

@article{montory_polybrominated_2012,
	title = {Polybrominated diphenyl ether levels in wild and farmed {Chilean} salmon and preliminary flow data for commercial transport.},
	volume = {24},
	issn = {1001-0742},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22655380},
	abstract = {This pilot study documented the occurrence and levels of brominated flame retardants in the tissues of farmed and wild salmon in southern Chile. Samples of Coho salmon and rainbow trout were obtained from fish farms, rivers and lakes in the Patagonia in Aysen Region, Chile. The samples were analyzed by Gas Chromatography Negative Chemical Ionization Mass Spectrometry for the different polybrominated diphenyl ether (PBDE) congeners. Contaminants were observed in all the samples, and the congeners BDE 17, 28, 47 and 66 were observed in all both farmed and wild samples. The concentrations were higher in the farmed Coho salmon, presenting significant differences with wild salmon. The levels reached 182 pg/g wet weight (ww) vs. 120 ww. In the case of the rainbow trout, the concentrations were lower, although the congener profile was quite similar. The levels reached an average of 100 pg/g ww in the farmed fish versus 110 pg/g ww in wild fish, and no significant difference was observed between the species. In both species, the congener with the highest concentration was BDE 47. Based on this information, the BDE flow was estimated for commerce, which is a form of pollutant transport not usually considered in POP pollution studies. A preliminary estimation indicated that the quantity of PBDEs mobilized by commerce was in the order of kg, and in the case of Chile might reach almost 1 kg.},
	number = {2},
	journal = {Journal of environmental sciences (China)},
	author = {Montory, Monica and Habit, Evelyn and Fernandez, Pilar and Grimalt, Joan O and Barra, Ricardo},
	month = jan,
	year = {2012},
	pmid = {22655380},
	keywords = {Animals, Aquaculture, Environmental Pollutants, Environmental Pollutants: analysis, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Pilot Projects, Salmon, chile},
	pages = {221--7},
}

Paper  doi  abstract   bibtex   

@article{alonso_natural_2012,
	title = {Natural and anthropogenically-produced brominated compounds in endemic dolphins from {Western} {South} {Atlantic}: another risk to a vulnerable species.},
	volume = {170},
	issn = {1873-6424},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22797349},
	doi = {10.1016/j.envpol.2012.06.001},
	abstract = {Liver samples from 53 Franciscana dolphins along the Brazilian coast were analyzed for organobrominated compounds. Target substances included the following anthropogenic pollutants: polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), pentabromoethylbenzene (PBEB), hexabromobenzene (HBB), decabromodiphenylethane (DBDPE), as well as the naturally-generated methoxylated-PBDEs (MeO-PBDEs). PBDE concentrations ranged from 6 to 1797 ng/g lw (mean 166 ± 298 ng/g lw) and were similar to those observed in cetaceans from Northern Hemisphere. PBBs were found in all sampling locations ({\textbackslash}textlessLOQ to 57 ng/g lw). DBDPE was detected in 42\% of the dolphins from the most industrialized Brazilian state and the concentrations ranging from {\textbackslash}textlessLOQ to 352 ng/g lw. Franciscana dolphins from the tropical Brazilian shore presented the highest MeO-PBDE concentrations ever reported for coastal cetaceans (up to 14 μg/g lw). Eight MeO-PBDE congeners were detected and the present investigation constituted the first record of occurrence of six of them in marine mammal livers.},
	journal = {Environmental pollution (Barking, Essex : 1987)},
	author = {Alonso, Mariana B and Eljarrat, Ethel and Gorga, Marina and Secchi, Eduardo R and Bassoi, Manuela and Barbosa, Lupércio and Bertozzi, Carolina P and Marigo, Juliana and Cremer, Marta and Domit, Camila and Azevedo, Alexandre F and Dorneles, Paulo R and Torres, João Paulo M and Lailson-Brito, José and Malm, Olaf and Barceló, Damià},
	month = nov,
	year = {2012},
	pmid = {22797349},
	keywords = {Animals, Atlantic Ocean, Brazil, Brominated, Brominated: analysis, Brominated: metabolism, Chemical, Chemical: analysis, Chemical: metabolism, Dolphins, Dolphins: metabolism, Environmental Monitoring, Female, Flame Retardants: analysis, Flame Retardants: metabolism, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: analysis, Halogenated Diphenyl Ethers: metabolism, Hydrocarbons, Liver, Liver: metabolism, Male, Polybrominated Biphenyls, Polybrominated Biphenyls: analysis, Polybrominated Biphenyls: metabolism, Water Pollutants},
	pages = {152--60},
}

Website  abstract   bibtex   

@article{
 title = {Host-gut microbiota metabolic interactions.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Aging,Animals,Bacteria,Bacteria: metabolism,Diet,Gastrointestinal Tract,Gastrointestinal Tract: metabolism,Gastrointestinal Tract: microbiology,Health,Humans,Immune System,Immune System: physiology,Inflammation,Liver,Liver: metabolism,Metabolic Diseases,Metabolic Diseases: metabolism,Metabolic Diseases: microbiology,Metabolic Networks and Pathways,Metagenome,Signal Transduction},
 pages = {1262-7},
 volume = {336},
 websites = {http://www.sciencemag.org.ezproxy.library.wisc.edu/content/336/6086/1262.long},
 month = {6},
 day = {8},
 id = {bd6afe2b-28a5-318b-84ed-c145f06e6ed2},
 created = {2016-06-24T20:49:29.000Z},
 accessed = {2014-07-10},
 file_attached = {false},
 profile_id = {954a987f-819f-3985-95a4-2991e0cf0552},
 group_id = {8440dcff-74cc-3783-aef7-fe2749cfc7ef},
 last_modified = {2016-06-24T20:49:29.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Nicholson2012},
 abstract = {The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.},
 bibtype = {article},
 author = {Nicholson, Jeremy K and Holmes, Elaine and Kinross, James and Burcelin, Remy and Gibson, Glenn and Jia, Wei and Pettersson, Sven},
 journal = {Science (New York, N.Y.)},
 number = {6086}
}

Website  abstract   bibtex   

@article{
 title = {Syndecan-1 promotes the angiogenic phenotype of multiple myeloma endothelial cells.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Animals,Cells, Cultured,Cultured,Endothelium,Endothelium: pathology,Flow Cytometry,Gene Silencing,Humans,Immunoprecipitation,Mice,Multiple Myeloma,Multiple Myeloma: blood supply,Multiple Myeloma: pathology,Neovascularization, Pathologic,Pathologic,Real-Time Polymerase Chain Reaction,Signal Transduction,Syndecan-1,Syndecan-1: genetics,Syndecan-1: physiology,Tumor Cells, Cultured,Vascular Endothelial Growth Factor A,Vascular Endothelial Growth Factor A: metabolism,Vascular Endothelial Growth Factor Receptor-2,Vascular Endothelial Growth Factor Receptor-2: met},
 pages = {1081-90},
 volume = {26},
 websites = {http://dx.doi.org/10.1038/leu.2011.290},
 month = {5},
 publisher = {Macmillan Publishers Limited},
 id = {0dc3a323-ae53-325a-9f8b-74d28f5e217a},
 created = {2016-06-24T20:50:03.000Z},
 accessed = {2014-12-01},
 file_attached = {false},
 profile_id = {954a987f-819f-3985-95a4-2991e0cf0552},
 group_id = {8440dcff-74cc-3783-aef7-fe2749cfc7ef},
 last_modified = {2016-06-24T20:50:03.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Lamorte2012},
 short_title = {Leukemia},
 abstract = {Angiogenesis is considered a hallmark of multiple myeloma (MM) progression. In the present study, we evaluated the morphological and functional features of endothelial cells (ECs) derived from bone marrow (BM) of patients affected by MM (MMECs). We found that MMECs compared with normal BM ECs (BMECs) showed increased expression of syndecan-1. Silencing of syndecan-1 expression by RNA interference technique decreased in vitro EC survival, proliferation and organization in capillary-like structures. In vivo, in severe combined immunodeficient mice, syndecan-1 silencing inhibited MMEC organization into patent vessels. When overexpressed in human umbilical vein ECs and BMECs, syndecan-1 induced in vitro and in vivo angiogenic effects. Flow-cytometric analysis of MMECs silenced for syndecan-1 expression indicated a decreased membrane expression of vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2). Immunoprecipitation and confocal analysis showed colocalization of VEGFR-2 with syndecan-1. Absence of nuclear translocation of VEGFR-2 in syndecan-1-knockdown cells together with the shift from perinuclear localization to recycling compartments suggest a role of syndecan-1 in modulation of VEGFR-2 localization. This correlated with an in vitro decreased VEGF-induced invasion and motility. These results suggest that syndecan-1 may contribute to the highly angiogenic phenotype of MMECs by promoting EC proliferation, survival and modulating VEGF-VEGFR-2 signalling.},
 bibtype = {article},
 author = {Lamorte, S and Ferrero, S and Aschero, S and Monitillo, L and Bussolati, B and Omedè, P and Ladetto, M and Camussi, G},
 journal = {Leukemia},
 number = {5}
}

Website  abstract   bibtex   

@article{
 title = {Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity},
 type = {article},
 year = {2011},
 identifiers = {[object Object]},
 keywords = {Analysis of Variance,Animals,Astrocytes,Astrocytes: drug effects,Astrocytes: metabolism,Blotting,Brain,Brain: drug effects,Brain: metabolism,Cell Survival,Cell Survival: drug effects,Cells,Cultured,Glutathione,Glutathione: metabolism,Heme Oxygenase-1,Heme Oxygenase-1: genetics,Heme Oxygenase-1: metabolism,Immunohistochemistry,Messenger,Messenger: genetics,Messenger: metabolism,Methylmercury Compounds,Methylmercury Compounds: metabolism,Methylmercury Compounds: pharmacology,Microglia,Microglia: drug effects,Microglia: metabolism,NF-E2-Related Factor 2,NF-E2-Related Factor 2: genetics,NF-E2-Related Factor 2: metabolism,Newborn,Oxidative Stress,Oxidative Stress: drug effects,RNA,Rats,Reactive Oxygen Species,Reactive Oxygen Species: metabolism,Small Interfering,Sprague-Dawley,Western},
 pages = {810-820},
 volume = {59},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3080116&tool=pmcentrez&rendertype=abstract},
 month = {5},
 id = {96d57e03-080d-328b-9894-60a295f16b47},
 created = {2012-02-06T18:35:34.000Z},
 accessed = {2012-01-30},
 file_attached = {true},
 profile_id = {1f6a330f-f6a3-36e6-abae-0954f070a071},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Ni2011},
 folder_uuids = {ef0eef76-72e0-41f4-97ad-0a486454f68c,ed1ada3f-9f8b-434b-9c9d-6416858928c5},
 private_publication = {false},
 abstract = {As the two major glial cell types in the brain, astrocytes and microglia play pivotal but different roles in maintaining optimal brain function. Although both cell types have been implicated as major targets of methylmercury (MeHg), their sensitivities and adaptive responses to this metal can vary given their distinctive properties and physiological functions. This study was carried out to compare the responses of astrocytes and microglia following MeHg treatment, specifically addressing the effects of MeHg on cell viability, reactive oxygen species (ROS) generation and glutathione (GSH) levels, as well as mercury (Hg) uptake and the expression of NF-E2-related factor 2 (Nrf2). Results showed that microglia are more sensitive to MeHg than astrocytes, a finding that is consistent with their higher Hg uptake and lower basal GSH levels. Microglia also demonstrated higher ROS generation compared with astrocytes. Nrf2 and its downstream genes were upregulated in both cell types, but with different kinetics (much faster in microglia). In summary, microglia and astrocytes each exhibit a distinct sensitivity to MeHg, resulting in their differential temporal adaptive responses. These unique sensitivities appear to be dependent on the cellular thiol status of the particular cell type.},
 bibtype = {article},
 author = {Ni, Mingwei and Li, Xin and Yin, Zhaobao and Sidoryk-Węgrzynowicz, Marta and Jiang, Haiyan and Farina, Marcelo and Rocha, Joao B. T. and Syversen, Tore and Aschner, Michael},
 journal = {GLIA},
 number = {5}
}

Paper  Website  abstract   bibtex   

@article{
 title = {iqr: A Tool for the Construction of Multi-level Simulations of Brain and Behaviour.},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Access to Information,Animal,Animals,Behavior,Behavior: physiology,Brain,Brain: physiology,Computer Simulation,Humans,Insects,Internet,Memory,Memory: physiology,Models,Neurological,Neurons,Neurons: physiology,Robotics,Software,Synapses,Synapses: physiology,Time Factors,User-Computer Interface},
 pages = {113-34},
 volume = {8},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/20502987},
 publisher = {Humana Press Inc.},
 id = {59515ef3-1a82-3d32-b933-751e65c1b13e},
 created = {2016-02-18T20:36:44.000Z},
 file_attached = {true},
 profile_id = {666a093a-6015-3506-8b43-c65cadb20ea2},
 last_modified = {2017-03-09T23:31:28.082Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Bernardet2010},
 source_type = {article},
 folder_uuids = {2e9f9bfc-4801-4871-9757-39a0ad79563e,79387ff2-9353-4bd0-8477-6c81b81f953f},
 abstract = {The brain is the most complex system we know of. Despite the wealth of data available in neuroscience, our understanding of this system is still very limited. Here we argue that an essential component in our arsenal of methods to advance our understanding of the brain is the construction of artificial brain-like systems. In this way we can encompass the multi-level organisation of the brain and its role in the context of the complete embodied real-world and real-time perceiving and behaving system. Hence, on the one hand, we must be able to develop and validate theories of brains as closing the loop between perception and action, and on the other hand as interacting with the real world. Evidence is growing that one of the sources of the computational power of neuronal systems lies in the massive and specific connectivity, rather than the complexity of single elements. To meet these challenges-multiple levels of organisation, sophisticated connectivity, and the interaction of neuronal models with the real-world-we have developed a multi-level neuronal simulation environment, iqr. This framework deals with these requirements by directly transforming them into the core elements of the simulation environment itself. iqr provides a means to design complex neuronal models graphically, and to visualise and analyse their properties on-line. In iqr connectivity is defined in a flexible, yet compact way, and simulations run at a high speed, which allows the control of real-world devices-robots in the broader sense-in real-time. The architecture of iqr is modular, providing the possibility to write new neuron, and synapse types, and custom interfaces to other hardware systems. The code of iqr is publicly accessible under the GNU General Public License (GPL). iqr has been in use since 1996 and has been the core tool for a large number of studies ranging from detailed models of neuronal systems like the cerebral cortex, and the cerebellum, to robot based models of perception, cognition and action to large-scale real-world systems. In addition, iqr has been widely used over many years to introduce students to neuronal simulation and neuromorphic control. In this paper we outline the conceptual and methodological background of iqr and its design philosophy. Thereafter we present iqr's main features and computational properties. Finally, we describe a number of projects using iqr, singling out how iqr is used for building a "synthetic insect".},
 bibtype = {article},
 author = {Bernardet, Ulysses and Verschure, Paul F.M.J.},
 journal = {Neuroinformatics},
 number = {2}
}

@article {93,
	title = {Medical treatment of autism spectrum disorders},
	journal = {Current Opinion in Neurology},
	volume = {23},
	number = {2},
	year = {2010},
	note = {LR: 20130118; GR: UA3 MC 11054/PHS HHS/United States; JID: 9319162; RF: 53; ppublish},
	month = {Apr},
	pages = {131-136},
	abstract = {PURPOSE OF REVIEW: There are several common medical conditions occurring in people with autism spectrum disorders (ASD) that can benefit from treatment and can in turn improve the health and quality of life of people with ASD. This review will primarily focus on these medical comorbidities, with a brief review of potential future treatments. RECENT FINDINGS: There continues to be disagreement regarding the exact prevalence and etiological significance of gastrointestinal conditions, epilepsy and other abnormal electroencephalographic findings, and sleep problems. It is not clear whether gastrointestinal conditions occur more frequently than in typically developing children, and whether there are distinct conditions that occur more often in ASD than in non-ASD populations. Abnormal electroencephalographic findings have been reported in up to 60\% of children with ASD, and some believe that these abnormalities may be responsible for parts of the ASD phenotype. Sleep problems are reported more frequently than in the general population, and effective treatments are available. Future medical treatments for ASD may be directed at underlying core symptoms and have greater impact than today{\textquoteright}s symptomatic approach. SUMMARY: Further research in these areas is needed to better guide diagnosis and treatment of a variety of medical conditions experienced by people with ASD.},
	keywords = {Animals, Brain Diseases/diagnosis/physiopathology/therapy, Child, Child Development Disorders, Gastrointestinal Diseases/diagnosis/physiopathology/therapy, Humans, Pervasive/diagnosis/physiopathology/therapy, Sleep Disorders/diagnosis/physiopathology/therapy},
	isbn = {1473-6551; 1350-7540},
	author = {Daniel L Coury}
}

@article{bessell_estimating_2010,
	title = {Estimating risk factors for farm-level transmission of disease: foot and mouth disease during the 2001 epidemic in {Great} {Britain}.},
	volume = {2},
	copyright = {Copyright (c) 2010 Elsevier B.V. All rights reserved.},
	issn = {1878-0067 1878-0067},
	doi = {10.1016/j.epidem.2010.06.002},
	abstract = {Controlling an epidemic would be aided by establishing whether particular individuals in infected populations are more likely to transmit infection. However, few analyses have characterised such individuals. Such analyses require  both data on who infected whom and on the likely determinants of transmission; data that are available at the farm level for the 2001 Foot and Mouth Disease epidemic in Great Britain. Using these data a putative number of daughter infected premises (IPs) resulting from each IP was calculated where these daughters were within 3km of the IP. A set of possible epidemiological, demographic, spatial and temporal risk factors were analysed, with the final multivariate generalised linear model (Poisson error term) having 6 statistically significant (p{\textless}0.05) main effects including geographic area, local cattle and sheep densities, and the number of non-IP culls. This model demonstrates that farms are heterogeneous in their propensity to transmit infection to other farms  and, importantly, that it may be possible to identify holdings that are at high risk of spreading disease a priori. Such information could be used to help prioritise the response to an epidemic.},
	language = {eng},
	number = {3},
	journal = {Epidemics},
	author = {Bessell, Paul R. and Shaw, Darren J. and Savill, Nicholas J. and Woolhouse, Mark E. J.},
	month = sep,
	year = {2010},
	pmid = {21352781},
	keywords = {Animal Husbandry, Animals, Cattle, Epidemics/prevention \& control/statistics \& numerical data/*veterinary, Foot-and-Mouth Disease Virus/physiology, Foot-and-Mouth Disease/epidemiology/*transmission, Models, Biological, Multivariate Analysis, Poisson Distribution, Risk Factors, Sheep, United Kingdom/epidemiology},
	pages = {109--115}
}

@article{hofmann_living_2010,
	title = {Living in the now: {Physiological} mechanisms to tolerate a rapidly changing environment.},
	volume = {72},
	journal = {Annual Review of Physiology},
	author = {Hofmann, G. E. and Todgham, A. E.},
	year = {2010},
	keywords = {disturbance, MCR, populations}
}

@article{spyrou_compounds_2010,
	title = {Compounds of the anthracycline family of antibiotics elevate human gamma-globin expression both in erythroid cultures and in a transgenic mouse model.},
	volume = {44},
	copyright = {Copyright (c) 2009 Elsevier Inc. All rights reserved.},
	issn = {1096-0961 1079-9796},
	doi = {10.1016/j.bcmd.2009.10.008},
	language = {eng},
	number = {2},
	journal = {Blood cells, molecules \& diseases},
	author = {Spyrou, Pandelis and Phylactides, Marios and Lederer, Carsten W. and Kithreotis, Lucas and Kirri, Andriani and Christou, Soteroulla and Kkolou, Elena and Kanavakis, Emanuel and Anagnou, Nicholas P. and Stamatoyannopoulos, George and Kleanthous, Marina},
	month = apr,
	year = {2010},
	pmid = {19914848},
	note = {Place: United States},
	keywords = {Animals, Anthracyclines/administration \& dosage/*pharmacology, Anti-Bacterial Agents/administration \& dosage/*pharmacology, Cell Line, Cells, Cultured, Erythroid Cells/drug effects, Fetal Hemoglobin/genetics/metabolism, Gene Expression Regulation/*drug effects, Humans, Mice, Mice, Transgenic, Promoter Regions, Genetic/drug effects, RNA, Messenger/genetics, Thalassemia/drug therapy/genetics, beta-Globins/genetics, gamma-Globins/*genetics},
	pages = {100--106},
}

Paper  doi  abstract   bibtex   

@article{nishijima_association_2010,
	title = {Association of thioautotrophic bacteria with deep-sea sponges.},
	volume = {12},
	issn = {1436-2236},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2891489&tool=pmcentrez&rendertype=abstract},
	doi = {10.1007/s10126-009-9253-7},
	abstract = {We investigated microorganisms associated with a deep-sea sponge, Characella sp. (Pachastrellidae) collected at a hydrothermal vent site (686 m depth) in the Sumisu Caldera, Ogasawara Island chain, Japan, and with two sponges, Pachastrella sp. (Pachastrellidae) and an unidentified Poecilosclerida sponge, collected at an oil seep (572 m depth) in the Gulf of Mexico, using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) directed at bacterial 16S rRNA gene sequences. In the PCR-DGGE profiles, we detected a single clearly dominant band in each of the Characella sp. and the unidentified Poecilosclerida sponge. BLAST search of their sequences showed that they were most similar ({\textgreater}99\% identity) to those of the gammaproteobacterial thioautotrophic symbionts of deep-sea bivalves from hydrothermal vents, Bathymodiolus spp. Phylogenetic analysis of the near-full length sequences of the 16S rRNA genes cloned from the unidentified Poecilosclerida sponge and Characella sp. confirmed that they were closely related to thioautotrophic symbionts. Although associations between sponges and methanotrophic bacteria have been reported previously, this is the first report of a possible stable association between sponges and thioautotrophic bacteria.},
	number = {3},
	journal = {Marine biotechnology (New York, N.Y.)},
	author = {Nishijima, Miyuki and Lindsay, Dhugal J and Hata, Junko and Nakamura, Aoi and Kasai, Hiroaki and Ise, Yuji and Fisher, Charles R and Fujiwara, Yoshihiro and Kawato, Masaru and Maruyama, Tadashi},
	month = jun,
	year = {2010},
	keywords = {16S, 16S: genetics, Animals, Bacteria, Bacteria: classification, Bacteria: genetics, Bacteria: isolation \& purification, Bacterial, Bacterial: genetics, Ecosystem, Electrophoresis, Gel, Geological Phenomena, Nucleic Acid Denaturation, Oceans and Seas, Phylogeny, Polymerase Chain Reaction, Porifera, Porifera: microbiology, RNA, Ribosomal, Symbiosis, Two-Dimensional, misaki},
	pages = {253--60}
}

Paper  doi  abstract   bibtex   

@article{,
   abstract = {In the United States, cancer is the second most common cause of death and it is expected that about 562,340 Americans will have died of cancer in 2009. Bone cancer pain is common in patients with advanced breast, prostate, and lung cancer as these tumors have a remarkable affinity to metastasize to bone. Once tumors metastasize to bone, they are a major cause of morbidity and mortality as the tumor induces significant skeletal remodeling, fractures, pain, and anemia. Currently, the factors that drive cancer pain are poorly understood. However, several recently introduced models of bone cancer pain, which closely mirror the human condition, are providing insight into the mechanisms that drive bone cancer pain and guide the development of mechanism-based therapies to treat the cancer pain. Several of these mechanism-based therapies have now entered human clinical trials. If successful, these therapies have the potential to significantly enlarge the repertoire of modalities that can be used to treat bone cancer pain and improve the quality of life, functional status, and survival of patients with bone cancer. © 2010 New York Academy of Sciences.},
   author = {Juan Miguel Jimenez-Andrade and William G. Mantyh and Aaron P. Bloom and Alice S. Ferng and Christopher P. Geffre and Patrick W. Mantyh},
   doi = {10.1111/J.1749-6632.2009.05429.X},
   isbn = {9781573317788},
   issn = {1749-6632},
   journal = {Annals of the New York Academy of Sciences},
   keywords = {Acidosis / etiology,Animal,Animals,Bone Neoplasms / epidemiology,Bone Neoplasms / mortality,Bone Neoplasms / pathology,Bone Neoplasms / physiopathology*,Bone Neoplasms / secondary,Bone and Bones / pathology,Breast Neoplasms / complications,Disease Models,Female,Humans,Juan Miguel Jimenez-Andrade,Lung Neoplasms / complications,MEDLINE,Male,Mice,NCBI,NIH,NLM,National Center for Biotechnology Information,National Institutes of Health,National Library of Medicine,Neoplasm Metastasis / pathology,Osteoclasts / pathology,PMC5642911,Pain / etiology,Pain / physiopathology*,Patrick W Mantyh,Prostatic Neoplasms / complications,PubMed Abstract,Review,Sarcoma / pathology,United States / epidemiology,William G Mantyh,doi:10.1111/j.1749-6632.2009.05429.x,pmid:20536932},
   pages = {173-181},
   pmid = {20536932},
   publisher = {Ann N Y Acad Sci},
   title = {Bone cancer pain},
   volume = {1198},
   url = {https://pubmed.ncbi.nlm.nih.gov/20536932/},
   year = {2010},
}

@article{guihard_mapk_2010,
	title = {The {MAPK} {ERK1} is a negative regulator of the adult steady-state splenic erythropoiesis},
	volume = {115},
	issn = {1528-0020},
	doi = {10.1182/blood-2009-09-242487},
	abstract = {The mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase 1 (ERK1) and ERK2 are among the main signal transduction molecules, but little is known about their isoform-specific functions in vivo. We have examined the role of ERK1 in adult hematopoiesis with ERK1(-/-) mice. Loss of ERK1 resulted in an enhanced splenic erythropoiesis, characterized by an accumulation of erythroid progenitors in the spleen, without any effect on the other lineages or on bone marrow erythropoiesis. This result suggests that the ablation of ERK1 induces a splenic stress erythropoiesis phenotype. However, the mice display no anemia. Deletion of ERK1 did not affect erythropoietin (EPO) serum levels or EPO/EPO receptor signaling and was not compensated by ERK2. Splenic stress erythropoiesis response has been shown to require bone morphogenetic protein 4 (BMP4)-dependent signaling in vivo and to rely on the expansion of a resident specialized population of erythroid progenitors, termed stress erythroid burst-forming units (BFU-Es). A great expansion of stress BFU-Es and increased levels of BMP4 mRNA were found in ERK1(-/-) spleens. The ERK1(-/-) phenotype can be transferred by bone marrow cells. These findings show that ERK1 controls a BMP4-dependent step, regulating the steady state of splenic erythropoiesis.},
	language = {eng},
	number = {18},
	journal = {Blood},
	author = {Guihard, Soizic and Clay, Denis and Cocault, Laurence and Saulnier, Nathalie and Opolon, Paule and Souyri, Michèle and Pagès, Gilles and Pouysségur, Jacques and Porteu, Françoise and Gaudry, Murielle},
	month = may,
	year = {2010},
	keywords = {Anemia, Animals, Apoptosis, Blotting, Western, Bone Marrow Transplantation, Bone Morphogenetic Protein 4, Colony-Forming Units Assay, Erythroid Precursor Cells, Erythropoiesis, Erythropoietin, Flow Cytometry, Mice, Mice, Inbred C57BL, Mitogen-Activated Protein Kinase 3, Oxidants, Phenylhydrazines, RNA, Messenger, Receptors, Erythropoietin, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, spleen},
	pages = {3686--3694},
}

Paper  doi  abstract   bibtex   

@article{pacyniak_mechanism_2010,
	title = {Mechanism of polybrominated diphenyl ether uptake into the liver: {PBDE} congeners are substrates of human hepatic {OATP} transporters.},
	volume = {115},
	issn = {1096-0929},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2871754&tool=pmcentrez&rendertype=abstract},
	doi = {10.1093/toxsci/kfq059},
	abstract = {Polybrominated diphenyl ethers (PBDEs) are flame-retardants that upon chronic exposure enter the liver where they are biotransformed to potentially toxic metabolites. The mechanism by which PBDEs enter the liver is not known. However, due to their large molecular weights (MWs approximately 485 to 1000 Da), they cannot enter hepatocytes by simple diffusion. Organic anion-transporting polypeptides (OATPs) are responsible for hepatic uptake of a variety of amphipathic compounds of MWs larger than 350 Da. Therefore, in the present study, Chinese hamster ovary cell lines expressing OATP1B1, OATP1B3, and OATP2B1 were used to test the hypothesis that OATPs expressed in human hepatocytes would be responsible for the uptake of PBDE congeners 47, 99, and 153. The results demonstrated that PBDE congeners inhibited OATP1B1- and OATP1B3-mediated uptake of estradiol-17-beta-glucuronide as well as OATP2B1-mediated uptake of estrone-3-sulfate in a concentration-dependent manner. Direct uptake studies confirmed that all three PBDE congeners are substrates for the three tested hepatic OATPs. Detailed kinetic analysis revealed that OATP1B1 transported 2,2',4,4'-tetrabromodiphenyl ether (BDE47) with the highest affinity (K(m) = 0.31 microM) followed by 2,2',4,4',5-pentabromodiphenyl ether (BDE99) (K(m) = 0.91 microM) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE153) (K(m) = 1.91 microM). For OATP1B3, the order was the same (BDE47: K(m) = 0.41 microM; BDE99: K(m) = 0.70 microM; BDE153: K(m) = 1.66 microM), while OATP2B1 transported all three congeners with similar affinities (BDE47: K(m) = 0.81 microM; BDE99: K(m) = 0.87 microM; BDE153: K(m) = 0.65 microM). These results clearly suggest that uptake of PBDEs via these OATPs is a mechanism responsible for liver-specific accumulation of PBDEs.},
	number = {2},
	journal = {Toxicological sciences : an official journal of the Society of Toxicology},
	author = {Pacyniak, Erik and Roth, Megan and Hagenbuch, Bruno and Guo, Grace L},
	month = jun,
	year = {2010},
	pmid = {20176623},
	keywords = {Animals, CHO Cells, CHO Cells: metabolism, Cricetinae, Cricetulus, Estradiol: analogs \& derivatives, Estradiol: metabolism, Estrone, Estrone: analogs \& derivatives, Estrone: metabolism, Flame Retardants: pharmacokinetics, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: pharmacokinetics, Hepatocytes, Hepatocytes: metabolism, Humans, Liver, Liver: metabolism, Organic Anion Transporters, Organic Anion Transporters: metabolism, estradiol},
	pages = {344--53},
}

Paper  doi  abstract   bibtex   

@article{nyholm_accumulation_2010,
	title = {Accumulation of polybrominated diphenyl ethers, hexabromobenzene, and 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane in earthworm ({Eisenia} fetida). {Effects} of soil type and aging.},
	volume = {44},
	issn = {1520-5851},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21028802},
	doi = {10.1021/es1023288},
	abstract = {In the present study the accumulation potentials in earthworms (Eisenia fetida) of selected brominated flame retardants (BFRs) were investigated. The tested BFRs, including polybrominated diphenyl ethers (PBDEs), hexabromobenzene (HBB), and 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (TBECH), were found to be bioavailable to Eisenia fetida, and they accumulated in the earthworms. To our knowledge, this is the first published study to address the bioaccumulation potential of TBECH in terrestrial biota. Aging the soil resulted in decreased accumulation of TBECH, HBB, and PBDEs with six or less bromine atoms. However, no effect of soil aging was seen for BDEs 183 or 209, possibly due to their low mobility in soil. The use of different soils (artificial OECD soil and two natural Swedish soils) also affected the degree of accumulation in the worms. The results indicate that use of the generally accepted standard OECD soil may overestimate accumulation of organic contaminants by earthworms, due to high bioavailability of the contaminants and/or weight loss of the worms in it. Further, the accumulation of selected PBDEs and HBB was compared to the accumulation of their chlorinated analogues. Brominated compounds accumulated to the same or a lesser extent than their chlorinated counterparts.},
	number = {23},
	journal = {Environmental science \& technology},
	author = {Nyholm, Jenny Rattfelt and Asamoah, Robert Kumah and van der Wal, Leon and Danielsson, Conny and Andersson, Patrik L},
	month = dec,
	year = {2010},
	pmid = {21028802},
	keywords = {Animals, Cyclohexanes, Cyclohexanes: metabolism, Environmental Monitoring, Flame Retardants: metabolism, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: metabolism, Oligochaeta, Oligochaeta: metabolism, Soil, Soil Pollutants, Soil Pollutants: metabolism, Soil: chemistry},
	pages = {9189--94},
}

Website  abstract   bibtex   

@article{
 title = {Conservation and divergence of methylation patterning in plants and animals.},
 type = {article},
 year = {2010},
 identifiers = {[object Object]},
 keywords = {Animals,Arabidopsis,Arabidopsis: genetics,DNA Methylation,DNA Methylation: genetics,Evolution,Exons,Exons: genetics,Introns,Introns: genetics,Molecular,Mutation,Mutation: genetics,Nucleic Acid,Nucleic Acid: genetics,Oligonucleotide Array Sequence Analysis,Open Reading Frames,Open Reading Frames: genetics,Phylogeny,Plants,Plants: genetics,Repetitive Sequences,Trans-Activators,Trans-Activators: genetics,Zebrafish,Zebrafish Proteins,Zebrafish Proteins: genetics,Zebrafish: genetics},
 pages = {8689-94},
 volume = {107},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2889301&tool=pmcentrez&rendertype=abstract},
 month = {5},
 id = {547cadeb-6193-3fc8-9ebd-cf6d888d2748},
 created = {2017-10-14T10:53:29.339Z},
 file_attached = {false},
 profile_id = {57cbaa4c-3609-3597-b91c-bd12e56638fb},
 group_id = {b97159aa-8fdc-3227-aa16-9de80bf090dd},
 last_modified = {2017-10-14T10:53:29.339Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Feng2010},
 source_type = {article},
 private_publication = {false},
 abstract = {Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. Although DNA methylation likely has a conserved role in gene silencing, the levels and patterns of DNA methylation appear to vary drastically among different organisms. Here we used shotgun genomic bisulfite sequencing (BS-Seq) to compare DNA methylation in eight diverse plant and animal genomes. We found that patterns of methylation are very similar in flowering plants with methylated cytosines detected in all sequence contexts, whereas CG methylation predominates in animals. Vertebrates have methylation throughout the genome except for CpG islands. Gene body methylation is conserved with clear preference for exons in most organisms. Furthermore, genes appear to be the major target of methylation in Ciona and honey bee. Among the eight organisms, the green alga Chlamydomonas has the most unusual pattern of methylation, having non-CG methylation enriched in exons of genes rather than in repeats and transposons. In addition, the Dnmt1 cofactor Uhrf1 has a conserved function in maintaining CG methylation in both transposons and gene bodies in the mouse, Arabidopsis, and zebrafish genomes.},
 bibtype = {article},
 author = {Feng, Suhua and Cokus, Shawn J and Zhang, Xiaoyu and Chen, Pao-Yang and Bostick, Magnolia and Goll, Mary G and Hetzel, Jonathan and Jain, Jayati and Strauss, Steven H and Halpern, Marnie E and Ukomadu, Chinweike and Sadler, Kirsten C and Pradhan, Sriharsa and Pellegrini, Matteo and Jacobsen, Steven E},
 journal = {Proceedings of the National Academy of Sciences of the United States of America},
 number = {19}
}

Paper  abstract   bibtex   

@article{
 title = {Impact of Bt -corn MON88017 in comparison to three conventional lines on Trigonotylus caelestialium (Kirkaldy) (Heteroptera: Miridae) field densities},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Cyperales,Field Crops (FF005) (New March 2000),GMOs,Gene Transfer and Transgenics,Genetic Engineering,Hemiptera,Heteroptera,Hexapoda,Miridae,Plant Breeding and Genetics (FF020),Plant Pests (FF620) (New March 2000),Poaceae,Spermatophyta,Trigonotylus,Trigonotylus coelestialium,Zea,Zea mays,angiosperms,animals,arthropods,corn,eukaryotes,genetically engineered plants,genetically modified plants,insect pests,insects,invertebrates,maize,monocotyledons,nontarget effects,nontarget organisms,plant pests,plants,risk assessment,transgenic plants},
 pages = {203-214},
 volume = {18},
 websites = {http://www.lib.ncsu.edu/cgi-bin/proxy.pl?server=http://search.ebscohost.com/login.aspx?direct=true&db=lah&AN=20093111513&site=ehost-live&scope=site,http://springerlink.metapress.com/link.asp?id=100225,email: Rauschen@Bio5.RWTH-Aachen.de,http://dx.doi.org/10.1007/s11248-008-9207-2},
 publisher = {Springer},
 city = {Dordrecht; Netherlands},
 id = {2bf1f556-5022-3a78-85be-1603b6126276},
 created = {2012-01-05T13:08:45.000Z},
 file_attached = {true},
 profile_id = {1a467167-0a41-3583-a6a3-034c31031332},
 group_id = {0e532975-1a47-38a4-ace8-4fe5968bcd72},
 last_modified = {2015-03-05T16:02:07.000Z},
 tags = {Bt corn,Europe,Germany,environmental,habitat,non-target},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 abstract = {In Europe, Bt-corn resistant against the European Corn Borer has until now been the only genetically modified plant to be grown commercially. With the advent of the Western Corn Rootworm Bt-corn varieties with resistance against Coleoptera will become important. The cultivation of Bt-plants may have negative impacts on non-target organisms, i.e. all species not explicitly targeted by a given Bt-crop. One prominent non-target group in corn are the herbivorous plant bugs (Heteroptera: Miridae). They are common, abundant and exposed to the Cry-protein. We therefore assessed the potential impact of the cultivation of the Cry3Bb1-expressing Bt-corn variety MON88017 and three conventional varieties on this group. Trigonotylus caelestialium (Kirkaldy) was the most abundant plant bug at the experimental field. There was no evidence for a negative impact of MON88017 on this species, despite its considerable exposure to Cry3Bb1 demonstrated with ELISA. The conventional corn varieties, however, had a consistent and significant influence on the field densities of this species over all three growing seasons.},
 bibtype = {article},
 author = {Rauschen, Stefan and Schultheis, Eva and Pagel-Wieder, Sibylle and Schuphan, Ingolf and Eber, Sabine},
 journal = {Transgenic Research},
 number = {2}
}

Website  abstract   bibtex   

@article{
 title = {Biomagnification of mercury in selected species from an Arctic marine food web in Svalbard.},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Animals,Arctic Regions,Birds,Birds: metabolism,Environmental Monitoring,Fishes,Fishes: metabolism,Food Chain,Mercury,Mercury: analysis,Mercury: pharmacokinetics,Methylmercury Compounds,Methylmercury Compounds: analysis,Methylmercury Compounds: pharmacokinetics,Models, Biological,Norway,Water Pollutants, Chemical,Water Pollutants, Chemical: analysis,Water Pollutants, Chemical: pharmacokinetics,Zooplankton,Zooplankton: metabolism},
 pages = {4744-51},
 volume = {407},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19454364},
 month = {8},
 publisher = {Elsevier B.V.},
 day = {1},
 id = {df3c07b5-1275-3e3a-9f84-d243c4d8997e},
 created = {2012-09-27T18:36:49.000Z},
 accessed = {2012-08-03},
 file_attached = {true},
 profile_id = {3ab1b9a1-7215-3216-a456-7c75cd1b2560},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Jaeger2009},
 folder_uuids = {4246fe96-2389-417f-9056-527e16d7e71c},
 private_publication = {false},
 abstract = {Concentrations and biomagnification of total mercury (TotHg) and methyl mercury (MeHg) were studied in selected species from the pelagic food web in Kongsfjorden, Svalbard. Twelve species of zooplankton, fish and seabirds, were sampled representing a gradient of trophic positions in the Svalbard marine food web. TotHg and MeHg were analysed in liver, muscle and/or whole specimens. The present study is the first to provide MeHg levels in seabirds from the Svalbard area. The relative MeHg levels decreased with increasing levels of TotHg in seabird tissues. Stable isotopes of nitrogen (delta(15)N) were used to determine the trophic levels and the rate of biomagnification of mercury in the food web. A linear relationship between mercury levels and trophic position was found for all seabird species combined and their trophic level, but there was no relationship within species. Biomagnification factors were all >1 for both TotHg and MeHg, indicating biomagnification from prey to predator. TotHg levels in the different seabirds were similar to levels detected in the Kongsfjorden area in the 1990s.},
 bibtype = {article},
 author = {Jaeger, Iris and Hop, Haakon and Gabrielsen, Geir W},
 journal = {The Science of the total environment},
 number = {16}
}

Paper  Website  abstract   bibtex   

@article{
 title = {The effect of CO2 acidified sea water and reduced salinity on aspects of the embryonic development of the amphipod Echinogammarus marinus (Leach).},
 type = {article},
 year = {2009},
 identifiers = {[object Object]},
 keywords = {Amphipoda,Amphipoda: growth & development,Animals,Carbon Dioxide,Carbon Dioxide: chemistry,Female,Hydrogen-Ion Concentration,Salinity,Seawater,Seawater: chemistry},
 pages = {1187-91},
 volume = {58},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19541328},
 month = {8},
 publisher = {Elsevier Ltd},
 id = {0111b01d-a0b1-333f-b64e-06e303ba9515},
 created = {2012-12-06T09:10:32.000Z},
 accessed = {2010-07-14},
 file_attached = {true},
 profile_id = {0b777e31-8c9d-39dd-97a3-3e054bd99cfe},
 group_id = {764582e8-5773-3a66-8d6b-9b40e4fb5a88},
 last_modified = {2017-03-14T17:27:14.020Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Egilsdottir2009b},
 abstract = {We investigated the effect of CO(2) acidified sea water (S=35, 22 and 10(PSU)) on embryonic development of the intertidal amphipod Echinogammarus marinus (Leach). Low pH, but not low salinity (22(PSU)), resulted in a more protracted embryonic development in situ although the effect was only evident at low salinity. However reduced salinity, not pH, exerted a strong significant effect, on numbers and calcium content of hatchlings. Females exposed to low salinity (10(PSU)) did not carry eggs through to hatching. There was no significant difference in the number of viable hatchlings between females cultured in 22 and 35(PSU) but the exoskeleton of the juveniles at 22(PSU) contained significantly less calcium. Ocean acidification may affect aspects of E. marinus development but exposure to realistic low salinities appear, in the short term, to be more important in impacting development than exposure to CO(2) acidified sea water at levels predicted for 300 years time.},
 bibtype = {article},
 author = {Egilsdottir, Hronn and Spicer, John I and Rundle, Simon D},
 journal = {Marine pollution bulletin},
 number = {8}
}

Paper  abstract   bibtex   

@article{gilder_montessori_2009,
	title = {Montessori by {Nature}},
	volume = {21},
	issn = {1054-0040, 1054-0040},
	url = {https://search.proquest.com/docview/61812099?accountid=14512},
	abstract = {This article discusses the Beyond the Walls outdoor education program at The Franklin Schools in Rockville, Maryland. Under the expert guidance of Maryland outdoor education specialist Amy Beam, Franklin's staff has been guided to reconnect to the landscape, understand native plants and animals, and reclaim a sense of gratitude for the environment that they can readily and enthusiastically share with the 285 children, ages 2 through 6, who attend the school. Beam advocates combining nature and nurture to meet the needs of the whole child and restore the balance between indoors and outdoors. Her pathway to environmental literacy is a welcome companion to all other literacies encouraged in Montessori classrooms. Franklin's three-acre campus, named a Certified Wildlife Habitat by the National Wildlife Federation, provides ample opportunities for the children to establish an early appreciation and stewardship of the area's natural resources. In the backyard of the campus is an area affectionately called, "The Back 40," where vegetation has been deliberately kept wild for the children to observe what is occurring in their immediate environment, and to investigate plants common to the area. In this article, the author provides some simple ways to connect children to nature.},
	language = {English},
	number = {4},
	journal = {Montessori Life: A Publication of the American Montessori Society},
	author = {Gilder, Sharon Allen},
	year = {2009},
	note = {Publisher: American Montessori Society, 281 Park Avenue South, New York, NY 10010-6102},
	keywords = {Early Childhood Education, Montessori Method, Teaching Methods, Environmental Education, Gardening, Young Children, Outdoor Education, Animals, Natural Resources, Plants (Botany), ERIC, Current Index to Journals in Education (CIJE), Maryland, Wildlife},
	pages = {34--37}
}

Paper  doi  abstract   bibtex   

@article{huang_receptor-fc_2009,
	title = {Receptor-{Fc} fusion therapeutics, traps, and {MIMETIBODY} technology.},
	volume = {20},
	issn = {1879-0429},
	url = {http://dx.doi.org/10.1016/j.copbio.2009.10.010},
	doi = {10.1016/j.copbio.2009.10.010},
	abstract = {Fc fusion proteins are molecules in which the immunoglobulin Fc is fused genetically to a protein of interest, such as an extracellular domain of a receptor, ligand, enzyme, or peptide. Fc fusion proteins have some antibody-like properties such as long serum half-life and easy expression and purification, making them an attractive platform for therapeutic drugs. Five Fc fusion based drugs are on the market presently, and many more are in different stages of clinical trials, demonstrating that Fc fusion proteins have become credible alternatives to monoclonal antibodies as therapeutics. This review summarizes the Fc fusion proteins that have been approved for use in the clinic and those that are currently in clinical trials, as well as the different approaches to design Fc fusion proteins.},
	number = {6},
	journal = {Current opinion in biotechnology},
	author = {Huang, Chichi},
	month = dec,
	year = {2009},
	keywords = {Animals, Antibodies, Biological, Biopharmaceutics, Biopharmaceutics: methods, Chemistry, Combinatorial Chemistry Techniques, Fc, Fc: chemistry, Humans, Immunoglobulin Fc Fragments, Immunoglobulin Fc Fragments: chemistry, Ligands, Models, Monoclonal, Monoclonal: chemistry, Peptides, Peptides: chemistry, Pharmaceutical, Pharmaceutical: methods, Protein Binding, Protein Engineering, Protein Engineering: methods, Receptors, Recombinant Fusion Proteins, Recombinant Fusion Proteins: chemistry},
	pages = {692--9},
}

Website  abstract   bibtex   

@article{
 title = {Concentrations of metals (zinc, copper, cadmium, and mercury) in three domestic ducks in France: Pekin, Muscovy, and Mule ducks},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Animals,Body Weight,Cadmium,Cadmium: analysis,Copper,Copper: analysis,Diet,Ducks,Ducks: genetics,Ducks: metabolism,France,Genotype,Mercury,Mercury: analysis,Species Specificity,Tissue Distribution,Zinc,Zinc: analysis},
 pages = {281-288},
 volume = {56},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/18072740},
 month = {1},
 day = {9},
 id = {524a6f96-1c0a-3aef-be5e-bba0c1800e47},
 created = {2012-03-19T12:36:45.000Z},
 file_attached = {true},
 profile_id = {1f6a330f-f6a3-36e6-abae-0954f070a071},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Lucia2008},
 folder_uuids = {ce502373-96bb-47fc-bf41-551912a25e17},
 private_publication = {false},
 abstract = {The role of different factors such as biological material (tissues, organs) and trophic condition (overfeeding or not) in the metal accumulation was studied in three genotypes of ducks (Pekin, Muscovy, and Mule) under breeding conditions. Results showed that overfeeding decreased the concentration in Cd, Cu, and Zn through the dilution process. In contrast, mercury concentration increased with this method. A relation between lipidic metabolism of genotypes and the distribution of this metal in biological material was found. Domestic ducks were little contaminated, but a low chronic contamination in Cd was observed, probably coming from the food. Due to the low levels of contamination observed in these breeding ducks, they can be considered as a good control for further contamination studies and comparison with accumulation levels recorded in the field. The impact of feeding condition on accumulation showed the importance of taking into account the life cycle of birds before studying their contamination and the impact of pollutants.},
 bibtype = {article},
 author = {Lucia, Magali and André, Jean-Marc and Bernadet, Marie-Dominique and Gontier, Karine and Gérard, Guy and Davail, Stéphane},
 journal = {Journal of Agricultural and Food Chemistry},
 number = {1}
}

Website  abstract   bibtex   

@article{
 title = {Interactive and cumulative effects of multiple human stressors in marine systems.},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Animals,Conservation of Natural Resources,Databases, Factual,Ecosystem,Humans,Marine Biology,Oceans and Seas,Stress, Physiological,Stress, Physiological: physiology},
 pages = {1304-15},
 volume = {11},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/19046359},
 month = {12},
 id = {fa62fa47-fae0-3625-9638-9fc72fd8481e},
 created = {2013-03-13T15:07:21.000Z},
 accessed = {2012-04-07},
 file_attached = {true},
 profile_id = {e1558f6e-62d1-3c37-86bf-f78fbeac509d},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-09-13T13:45:29.603Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Crain2008},
 folder_uuids = {f143949d-9cdb-43da-b0d7-73afc391fe35},
 private_publication = {false},
 abstract = {Humans impact natural systems in a multitude of ways, yet the cumulative effect of multiple stressors on ecological communities remains largely unknown. Here we synthesized 171 studies that manipulated two or more stressors in marine and coastal systems and found that cumulative effects in individual studies were additive (26%), synergistic (36%), and antagonistic (38%). The overall interaction effect across all studies was synergistic, but interaction type varied by response level (community: antagonistic, population: synergistic), trophic level (autotrophs: antagonistic, heterotrophs: synergistic), and specific stressor pair (seven pairs additive, three pairs each synergistic and antagonistic). Addition of a third stressor changed interaction effects significantly in two-thirds of all cases and doubled the number of synergistic interactions. Given that most studies were performed in laboratories where stressor effects can be carefully isolated, these three-stressor results suggest that synergies may be quite common in nature where more than two stressors almost always coexist. While significant gaps exist in multiple stressor research, our results suggest an immediate need to account for stressor interactions in ecological studies and conservation planning.},
 bibtype = {article},
 author = {Crain, Caitlin Mullan and Kroeker, Kristy and Halpern, Benjamin S},
 journal = {Ecology letters},
 number = {12}
}

Paper  doi  abstract   bibtex   

@article{goldbaum_expression_2008,
	title = {The expression of tubulin polymerization promoting protein {TPPP}/p25α is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress},
	volume = {56},
	copyright = {Copyright © 2008 Wiley‐Liss, Inc.},
	issn = {1098-1136},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.20720},
	doi = {10.1002/glia.20720},
	abstract = {The tubulin polymerization-promoting protein (TPPP)/p25α was identified as a brain specific protein, is associated with microtubules (MTs) in vitro and can promote abnormal MT assembly. Furthermore it has aggregation promoting properties and is a constituent in pathological protein deposits of neurodegenerative diseases. In the brain, TPPP/p25α is present in myelinating oligodendrocytes. Here we show, using cultured rat brain oligodendrocytes, that TPPP/p25α expression is increasing during development in culture, and particularly in immature cells is associated with the centrosome. MT binding properties in oligodendrocytes are rather low, however, when MTs are disassembled by nocodazole, TPPP/p25α accumulates in the perinuclear region. Treatment of oligodendrocytes with the proteasomal inhibitor MG-132 (1 μM; 18 h) caused an increase in the amount of TPPP/p25α by about 40\%, a decrease in its solubility, and led to the appearance of TPPP/p25α-positive cytoplasmic inclusions, which stained with thioflavin S and resembled inclusion bodies. Hence, it might be speculated that acute or chronic malfunction of the proteasomal degradation system, leading to the accumulation of aggregation prone proteins and the pro-aggregatory protein TPPP/p25α or to the aggregation of TPPP/p25α on its own, is causally related to the protein aggregation process in a variety of neurodegenerative diseases. © 2008 Wiley-Liss, Inc.},
	language = {en},
	number = {16},
	urldate = {2018-05-21},
	journal = {Glia},
	author = {Goldbaum, Olaf and Jensen, Poul Henning and Richter‐Landsberg, Christiane},
	month = dec,
	year = {2008},
	keywords = {Animals, Brain, Carrier Proteins, Cell Differentiation, Cells, Centrosome, Cultured, Developmental, Enzyme Inhibitors, Gene Expression Regulation, Inclusion Bodies, Leupeptins, MSA, Nerve Tissue Proteins, Nocodazole, Oligodendroglia, Peptide Hydrolases, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Rats, Tubulin, Tubulin Modulators, Up-Regulation, Wistar, glial inclusion body, microtubules, proteolytic stress, α-synuclein},
	pages = {1736--1746},
}

Paper  doi  abstract   bibtex   

@article{tabone-eglinger_kit_2008,
	title = {{KIT} mutations induce intracellular retention and activation of an immature form of the {KIT} protein in gastrointestinal stromal tumors},
	volume = {14},
	issn = {1078-0432 (PRINT) 1078-0432 (LINKING)},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18413817},
	doi = {14/8/2285 [pii] 10.1158/1078-0432.CCR-07-4102},
	abstract = {PURPOSE: Gastrointestinal stromal tumors (GIST) are frequently associated with gain-of-function mutations of KIT, which can be inhibited by imatinib both in vitro and in vivo. The survival of patients with GIST, following imatinib therapy, has been correlated with the nature of mutations but not with KIT expression. EXPERIMENTAL DESIGN: Subcellular localization, activation, and trafficking of the mature and the immature forms of KIT were investigated in GIST samples and in NIH3T3 cells infected with two different GIST-type exon 11-mutated human KIT cDNA. RESULTS: Paranuclear dot expression of KIT was more frequent in GISTs with homozygous KIT mutations than in those with heterozygous (P = 0.01) or no mutations (P {\textless} 0.01). Activation of the immature 125 kDa form of KIT was detected in most GISTs with KIT mutations but not in GISTs without KIT mutations. In NIH3T3 cells, mutant KIT was mainly retained within endoplasmic reticulum and Golgi compartments in an immature constitutively phosphorylated form, whereas the wild-type KIT was expressed at the plasma membrane, in a mature nonphosphorylated form. Imatinib-induced inhibition of the phosphorylation of immature and mature mutant KIT proteins resulted in the restoration of KIT expression at the cell surface. CONCLUSIONS: These results show that GIST-type KIT mutations induce an activation-dependent alteration of normal maturation and trafficking, resulting in the intracellular retention of the activated kinase within the cell. These observations likely account for the absence of correlation between response to imatinib and KIT expression using immunohistochemistry and may deserve to be investigated in other tyrosine kinase-activated tumors.},
	number = {8},
	journal = {Clin Cancer Res},
	author = {Tabone-Eglinger, S. and Subra, F. and El Sayadi, H. and Alberti, L. and Tabone, E. and Michot, J. P. and Theou-Anton, N. and Lemoine, A. and Blay, J. Y. and Emile, J. F.},
	year = {2008},
	keywords = {*Mutation, 3T3, Animals, Cell, Cells, Factor/pharmacology, Gastrointestinal, Humans, Mice, NIH, Phosphorylation, Proteins, Proto-Oncogene, Stem, Stromal, Tumors/genetics/*metabolism, c-kit/*genetics/*metabolism},
	pages = {2285--94},
}

Website  abstract   bibtex   

@article{
 title = {Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.},
 type = {article},
 year = {2008},
 identifiers = {[object Object]},
 keywords = {Animals,Antigens,Antineoplastic Agents,Antineoplastic Agents: pharmacology,B-Lymphocytes,B-Lymphocytes: pathology,Boronic Acids,Boronic Acids: pharmacology,CD20,CD20: analysis,CD27,CD27: analysis,Clone Cells,Clone Cells: drug effects,Clone Cells: pathology,Cyclophosphamide,Cyclophosphamide: analogs & derivatives,Cyclophosphamide: pharmacology,Dexamethasone,Dexamethasone: pharmacology,Drug Resistance,Humans,Inbred Strains,Mice,Multiple Myeloma,Multiple Myeloma: pathology,Neoplasm,Neoplastic Stem Cells,Neoplastic Stem Cells: drug effects,Neoplastic Stem Cells: pathology,Plasma Cells,Plasma Cells: drug effects,Plasma Cells: pathology,Pyrazines,Pyrazines: pharmacology,Syndecan-1,Syndecan-1: analysis,Thalidomide,Thalidomide: analogs & derivatives,Thalidomide: pharmacology,Tumor Stem Cell Assay},
 pages = {190-7},
 volume = {68},
 websites = {http://cancerres.aacrjournals.org/content/68/1/190.full},
 month = {1},
 day = {1},
 id = {494ed8c9-5c08-3403-8b42-0d004f92312a},
 created = {2016-06-24T20:49:19.000Z},
 accessed = {2014-11-18},
 file_attached = {false},
 profile_id = {954a987f-819f-3985-95a4-2991e0cf0552},
 group_id = {8440dcff-74cc-3783-aef7-fe2749cfc7ef},
 last_modified = {2016-06-24T20:49:19.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Matsui2008},
 abstract = {Many agents are active in multiple myeloma, but the majority of patients relapse. This clinical pattern suggests most cancer cells are eliminated, but cells with the clonogenic potential to mediate tumor regrowth are relatively chemoresistant. Our previous data suggested that CD138(+) multiple myeloma plasma cells cannot undergo long-term proliferation but rather arise from clonogenic CD138(neg) B cells. We compared the relative sensitivity of these distinct cell types to clinical antimyeloma agents and found that dexamethasone, lenadilomide, bortezomib, and 4-hydroxycyclophosphamide inhibited CD138(+) multiple myeloma plasma cells but had little effect on CD138(neg) precursors in vitro. We further characterized clonogenic multiple myeloma cells and stained cell lines using the Hoechst side population and Aldefluor assays. Each assay identified CD138(neg) cells suggesting that they possess high drug efflux capacity and intracellular drug detoxification activity. We also found that multiple myeloma cells expressing the memory B-cell markers CD20 and CD27 could give rise to clonogenic multiple myeloma growth in vitro and engraft immunodeficient nonobese diabetes/severe combined immunodeficient mice during both primary and secondary transplantation. Furthermore, both the side population and Aldefluor assays were capable of identifying circulating clonotypic memory B-cell populations within the peripheral blood of multiple myeloma patients. Our results suggest that circulating clonotypic B-cell populations represent multiple myeloma stem cells, and the relative drug resistance of these cells is mediated by processes that protect normal stem cells from toxic injury.},
 bibtype = {article},
 author = {Matsui, William and Wang, Qiuju and Barber, James P and Brennan, Sarah and Smith, B Douglas and Borrello, Ivan and McNiece, Ian and Lin, Lan and Ambinder, Richard F and Peacock, Craig and Watkins, D Neil and Huff, Carol Ann and Jones, Richard J},
 journal = {Cancer research},
 number = {1}
}

@article{abrahams_advances_2008,
	title = {Advances in autism genetics: on the threshold of a new neurobiology.},
	volume = {9},
	doi = {10.1038/nrg2346},
	abstract = {Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.},
	language = {eng},
	number = {5},
	journal = {Nat Rev Genet},
	author = {Abrahams, Brett S and Geschwind, Daniel H},
	year = {2008},
	pmid = {18414403},
	note = {Place: England
ISBN: 1471-0064},
	keywords = {Animals, Autism, Autistic Disorder, Gene Dosage, Gene Expression Profiling, Gene Expression Regulation, Genetic Predisposition to Disease, Humans, Oligonucleotide Array Sequence Analysis, Phenotype, Systems Biology, research support, n.i.h., extramural, research support, non-u.s. gov't, review},
	pages = {341--355},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Effects of anthropogenic seawater acidification on acid-base balance in the sea urchin Psammechinus miliaris.},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {Acid-Base Equilibrium,Acid-Base Equilibrium: physiology,Animals,Bicarbonates,Bicarbonates: analysis,Carbon Dioxide,Carbon Dioxide: analysis,Carbon Dioxide: physiology,Hydrogen-Ion Concentration,Magnesium,Magnesium: analysis,Sea Urchins,Sea Urchins: metabolism,Seawater,Seawater: chemistry},
 pages = {89-96},
 volume = {54},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/17083950},
 month = {1},
 id = {630102e9-9501-3c53-bf49-3f49073c5f86},
 created = {2012-12-06T09:13:40.000Z},
 accessed = {2012-10-30},
 file_attached = {true},
 profile_id = {0b777e31-8c9d-39dd-97a3-3e054bd99cfe},
 group_id = {764582e8-5773-3a66-8d6b-9b40e4fb5a88},
 last_modified = {2017-03-14T17:27:14.020Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Miles2007},
 abstract = {The purple-tipped sea urchin, Psammechinus miliaris, was exposed to artificially acidified seawater treatments (pH(w) 6.16, 6.63 or 7.44) over a period of 8 days. Urchin mortality of 100% was observed at pH(w) 6.16 after 7 days and coincided with a pronounced hypercapnia in the coelomic fluid producing an irrecoverable acidosis. Coelomic fluid acid-base measures showed that an accumulation of CO(2) and a significant reduction in pH occurred in all treatments compared with controls. Bicarbonate buffering was employed in each case, reducing the resultant acidosis, but compensation was incomplete even under moderate environmental hypercapnia. Significant test dissolution was inferred from observable increases in the Mg(2+) concentration of the coelomic fluid under all pH treatments. We show that a chronic reduction of surface water pH to below 7.5 would be severely detrimental to the acid-base balance of this predominantly intertidal species; despite its ability to tolerate fluctuations in pCO(2) and pH in the rock pool environment. The absence of respiratory pigment (or any substantial protein in the coelomic fluid), a poor capacity for ionic regulation and dependency on a magnesium calcite test, make echinoids particularly vulnerable to anthropogenic acidification. Geological sequestration leaks may result in dramatic localised pH reductions, e.g. pH 5.8. P. miliaris is intolerant of pH 6.16 seawater and significant mortality is seen at pH 6.63.},
 bibtype = {article},
 author = {Miles, Hayley and Widdicombe, Stephen and Spicer, John I and Hall-Spencer, Jason},
 journal = {Marine pollution bulletin},
 number = {1}
}

Paper  abstract   bibtex   

@article{takimoto_intraguild_2007,
	title = {Intraguild predation promotes complex alternative states along a productivity gradient.},
	volume = {72},
	issn = {0040-5809},
	url = {http://search.ebscohost.com/login.aspx?direct=true&db=cmedm&AN=17573086&site=ehost-live},
	abstract = {Intraguild predation is the simplest, ubiquitous form of trophic omnivory, known to greatly influence the structure and functioning of natural and managed food webs. Although alternative states are fundamental to intraguild predation dynamics, only necessary conditions for alternative states have been previously reported. Using simple models, we found complex but systematic patterns in which different alternative states occur along a productivity gradient, and clarified the sufficient conditions to separate these patterns. We found that two quantities known to control the necessary conditions also determine the sufficient conditions: (1) relative energy transfer efficiency through alternative trophic pathways to an intraguild predator, and (2) relative resource exploitation ability between intraguild prey and predator. These governing quantities suggest how body size and stoichiometric relations between intraguild prey and predators can influence the possibility of alternative states. Our results indicate that food webs involving intraguild predation have a high potential of complex alternative states, and their management can be highly precarious.},
	number = {2},
	journal = {Theoretical population biology},
	author = {Takimoto, Gaku and Miki, Takeshi and Kagami, Maiko},
	month = sep,
	year = {2007},
	note = {Place: United States
Publisher: Academic Press},
	keywords = {Animals, Body Size, Ecosystem*, Food Chain*, Models, Statistical, Predatory Behavior*},
	pages = {264--273},
}

@article{kiani_object_2007,
	title = {Object category structure in response patterns of neuronal population in monkey inferior temporal cortex.},
	volume = {97},
	doi = {10.1152/jn.00024.2007},
	abstract = {Our mental representation of object categories is hierarchically organized, and our rapid and seemingly effortless categorization ability is crucial for our daily behavior. Here, we examine responses of a large number ({\textgreater}600) of neurons in monkey inferior temporal (IT) cortex with a large number ({\textgreater}1,000) of natural and artificial object images. During the recordings, the monkeys performed a passive fixation task. We found that the categorical structure of objects is represented by the pattern of activity distributed over the cell population. Animate and inanimate objects created distinguishable clusters in the population code. The global category of animate objects was divided into bodies, hands, and faces. Faces were divided into primate and nonprimate faces, and the primate-face group was divided into human and monkey faces. Bodies of human, birds, and four-limb animals clustered together, whereas lower animals such as fish, reptile, and insects made another cluster. Thus the cluster analysis showed that IT population responses reconstruct a large part of our intuitive category structure, including the global division into animate and inanimate objects, and further hierarchical subdivisions of animate objects. The representation of categories was distributed in several respects, e.g., the similarity of response patterns to stimuli within a category was maintained by both the cells that maximally responded to the category and the cells that responded weakly to the category. These results advance our understanding of the nature of the IT neural code, suggesting an inherently categorical representation that comprises a range of categories including the amply investigated face category.},
	language = {eng},
	number = {6},
	journal = {J Neurophysiol},
	author = {Kiani, Roozbeh and Esteky, Hossein and Mirpour, Koorosh and Tanaka, Keiji},
	year = {2007},
	pmid = {17428910},
	note = {Place: United States
ISBN: 0022-3077},
	keywords = {Action Potentials, Animals, Behavior, Animal, Brain Mapping, Cluster Analysis, Humans, Macaca mulatta, Neurons, Pattern Recognition, Visual, Photic Stimulation, Probability, Reaction Time, Temporal Lobe, Visual Pathways, research support, non-u.s. gov't},
	pages = {4296--4309},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Maternal transfer of organohalogen contaminants and metabolites to eggs of Arctic-breeding glaucous gulls.},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Animals,Arctic Regions,Biological Transport,Charadriiformes,Charadriiformes: metabolism,Eggs,Eggs: analysis,Environmental Monitoring,Environmental Monitoring: methods,Environmental Pollutants,Environmental Pollutants: analysis,Environmental Pollutants: blood,Environmental Pollutants: metabolism,Female,Gas Chromatography-Mass Spectrometry,Mothers,Norway,Pesticide Residues,Pesticide Residues: analysis,Pesticide Residues: blood,Pesticide Residues: metabolism,Polychlorinated Biphenyls,Polychlorinated Biphenyls: analysis,Polychlorinated Biphenyls: blood,Polychlorinated Biphenyls: metabolism},
 pages = {1053-60},
 volume = {144},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16563578},
 month = {12},
 id = {740e5ba5-c77d-366e-a109-7383cb39d7ff},
 created = {2012-10-26T12:49:03.000Z},
 accessed = {2012-10-26},
 file_attached = {true},
 profile_id = {c6c6f844-18d2-32db-a619-2e915134a952},
 group_id = {764582e8-5773-3a66-8d6b-9b40e4fb5a88},
 last_modified = {2017-03-14T17:27:14.020Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Verreault2006},
 abstract = {Eggs of seabirds have routinely been used as indicators of environmental pollution in the Arctic. However, the variability in organohalogen concentration and composition associated with the laying sequence, have not been defined. We examined a suite of PCBs, organochlorine (OC) pesticides and by-products, polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs) and methylsulfonyl- (MeSO2) PCBs in complete 3-egg clutches of glaucous gulls (Larus hyperboreus), and plasma samples of the laying females collected from the Norwegian Arctic. SigmaPCB, SigmaOC and SigmaPBDE, but not SigmaMeSO2-PCB, concentrations in eggs were positively associated, with increasing magnitude and significance from the first through the last-laid egg, with concentrations in female plasma. However, the concentrations of these organohalogen classes fluctuated irrespective of the laying order in the clutch. In general, maternal transfer favored low K(ow) and/or less persistent compounds, whereas the recalcitrant and/or higher-halogenated compounds were less readily transferred, and consequently more selectively retained in the mother.},
 bibtype = {article},
 author = {Verreault, Jonathan and Villa, Rosa a and Gabrielsen, Geir W and Skaare, Janneche U and Letcher, Robert J},
 journal = {Environmental pollution (Barking, Essex : 1987)},
 number = {3}
}

Paper  abstract   bibtex   

@article{law_bioaccumulation_2006,
	title = {Bioaccumulation and trophic transfer of some brominated flame retardants in a {Lake} {Winnipeg} ({Canada}) food web.},
	volume = {25},
	issn = {0730-7268},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/16916037},
	abstract = {The extent of bioaccumulation and trophic transfer of brominated diphenyl ether (BDE) congeners, hexabromocyclododecane (HBCD) diastereoisomers (alpha, beta, and gamma), decabromodiphenylethane (DBDPE), and bis(2,4,6-tribromophenoxy)ethane (BTBPE) was examined in a Lake Winnipeg (Canada) food web. Six species of fish, zooplankton, mussels, sediment, and water from the south basin of the lake were selected for study. Significant positive correlations were found between concentrations of total (sigma) polybrominated diphenylethers (PBDEs; p {\textbackslash}textless 0.005), sigmaHBCDs (p {\textbackslash}textless 0.0001), BTBPE (p {\textbackslash}textless 0.0001), and lipid content in fish. Strong positive linear relationships also were observed from individual plots of BDE 47, BDE 209, and DBDPE concentrations (lipid wt) and trophic level (based on delta15N), suggesting that these compounds biomagnify in the Lake Winnipeg food web. Biomagnification factors varied for the chemicals studied. Plots of log bioaccumulation factors for mussel and zooplankton versus log octanol-water partition coefficient (Kow) were similar and suggest that neither mussels nor zooplankton are in equilibrium with the water. Fifteen BDE congeners were consistently detected in water (dissolved phase, n = 3), with BDE 47 having the greatest concentration (17 pg/L). The rank order of compounds in water (arithmetic mean +/- standard error) were sigmaPBDEs (49 +/- 12 pg/ L) {\textbackslash}textgreater alpha-HBCD (11 +/- 2 pg/L) {\textbackslash}textgreater BTBPE (1.9 +/- 0.6 pg/L). Concentrations of DPDPE, BDE 209, and beta- and -gamma-HBCD isomers were below their respective method detection limits (MDLs) in water. Total PBDE concentrations in sediment (n = 4) were greater than any other brominated flame retardant examined in the present study and ranged from 1,160 to 1,610 ng/g (dry wt), with BDE 209 contributing roughly 50\% of the total. The gamma-HBCD isomer was detected at concentrations of 50 +/- 20 pg/g (dry wt) in sediment, whereas BTBPE and DBDPE were consistently below their respective MDLs in sediment.},
	number = {8},
	journal = {Environmental toxicology and chemistry / SETAC},
	author = {Law, Kerri and Halldorson, Thor and Danell, Robert and Stern, Gary and Gewurtz, Sarah and Alaee, Mehran and Marvin, Chris and Whittle, Mike and Tomy, Gregg},
	month = aug,
	year = {2006},
	pmid = {16916037},
	keywords = {Animals, Bromine, Bromine: metabolism, Canada, Chromatography, Flame Retardants: metabolism, Flame retardants, Food Chain, Gas Chromatography-Mass Spectrometry, High Pressure Liquid, Mass Spectrometry, Quality Control, Reference Standards, Sensitivity and Specificity, ffr, frbldg, frelec, waa},
	pages = {2177--86},
}

Paper  doi  abstract   bibtex   

@article{Karniel2005,
	title = {Computational analysis in vitro: dynamics and plasticity of a neuro-robotic system.},
	volume = {2},
	issn = {1741-2560},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/16135888},
	doi = {10.1088/1741-2560/2/3/S08},
	abstract = {When the brain interacts with the environment it constantly adapts by representing the environment in a form that is called an internal model. The neurobiological basis for internal models is provided by the connectivity and the dynamical properties of neurons. Thus, the interactions between neural tissues and external devices provide a fundamental means for investigating the connectivity and dynamical properties of neural populations. We developed this idea, suggested in the 1980s by Valentino Braitenberg, for investigating and representing the dynamical behavior of neuronal populations in the brainstem of the lamprey. The brainstem was maintained in vitro and connected in a closed loop with two types of artificial device: (a) a simulated dynamical system and (b) a small mobile robot. In both cases, the device was controlled by recorded extracellular signals and its output was translated into electrical stimuli delivered to the neural system. The goal of the first study was to estimate the dynamical dimension of neural preparation in a single-input/single-output configuration. The dynamical dimension is the number of state variables that together with the applied input determine the output of a system. The results indicate that while this neural system has significant dynamical properties, its effective complexity, as established by the dynamical dimension, is rather moderate. In the second study, we considered a more specific situation, in which the same portion of the nervous system controls a robotic device in a two-input/two-output configuration. We fitted the input-output data from the neuro-robotic preparation to neural network models having different internal dynamics and we observed the generalization error of each model. Consistent with the first study, this second experiment showed that a simple recurrent dynamical model was able to capture the behavior of the hybrid system. This experimental and computational framework provides the means for investigating neural plasticity and internal representations in the context of brain-machine interfaces.},
	number = {3},
	urldate = {2012-07-20},
	journal = {J. Neural Eng.},
	author = {Karniel, Amir and Kositsky, Michael and Fleming, Karen M and Chiappalone, Michela and Sanguineti, Vittorio and Alford, Simon T and Mussa-Ivaldi, Ferdinando a},
	month = sep,
	year = {2005},
	pmid = {16135888},
	keywords = {Animals, Brain, Brain: physiology, Cybernetics, Cybernetics: methods, Humans, Lampreys, Man-Machine Systems, Models, Nerve Net, Nerve Net: physiology, Neurological, Neuronal Plasticity, Neuronal Plasticity: physiology, Robotics, Robotics: methods, User-Computer Interface},
	pages = {S250--65},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Bioaccumulation of PCBs in the cuttlefish Sepia officinalis from seawater, sediment and food pathways.},
 type = {article},
 year = {2005},
 identifiers = {[object Object]},
 keywords = {Animals,Environmental Monitoring,Environmental Monitoring: methods,Environmental Pollutants,Environmental Pollutants: analysis,Environmental Pollutants: pharmacokinetics,Food Chain,Geologic Sediments,Mollusca,Mollusca: chemistry,Mollusca: metabolism,Polychlorinated Biphenyls,Polychlorinated Biphenyls: analysis,Polychlorinated Biphenyls: pharmacokinetics,Seawater},
 pages = {113-22},
 volume = {134},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/15572229},
 month = {3},
 id = {9bd781c2-cfe1-3349-a68b-f151c790002a},
 created = {2010-09-15T14:45:54.000Z},
 accessed = {2010-09-15},
 file_attached = {true},
 profile_id = {c6c6f844-18d2-32db-a619-2e915134a952},
 last_modified = {2017-03-31T08:28:21.048Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Danis2005a},
 folder_uuids = {b555a2ae-97cc-4492-ae3a-910c81afb80f,a6bf1321-9beb-4f7c-9715-6ab10e069d78},
 abstract = {The cuttlefish Sepia officinalis was selected as a model cephalopod to study PCB bioaccumulation via seawater, sediments and food. Newly hatched, juvenile cuttlefish were exposed for 17 days to environmentally realistic concentrations of (14)C-labeled 2,2',4,4',5,5'-hexachlorobiphenyl (PCB#153) (18 ng PCB l(-1) seawater; 30 ng PCB g(-1) dry wt sediments; Artemia salina exposed to 18 ng PCB l(-1) seawater). Accumulation of PCB#153 was followed in three body compartments: digestive gland, cuttlebone and the combined remaining tissues. Results showed that (1) uptake kinetics were source- and body compartment-dependent, (2) for each body compartment, the accumulation was far greater when S. officinalis was exposed via seawater, (3) the cuttlebone accumulated little of the contaminant regardless of the source, and (4) the PCB congener showed a similar distribution pattern among the different body compartments following exposure to contaminated seawater, sediment or food with the lowest concentrations in the cuttlebone and the highest in the remaining tissues. The use of radiotracer techniques allowed delineating PCB kinetics in small whole organisms as well as in their separate tissues. The results underscore the enhanced ability of cephalopods to concentrate organic pollutants such as PCBs, and raise the question of potential risk to their predators in contaminated areas.},
 bibtype = {article},
 author = {Danis, B and Bustamante, P and Cotret, O and Teyssié, J L and Fowler, S W and Warnau, M},
 journal = {Environmental pollution (Barking, Essex : 1987)},
 number = {1}
}

@Article{Granada_2005_989,
  author = {Granada, J.F. and Moreno, P.R. and Burke, A.P. and Schulz, D.G. and Raizner, A.E. and Kaluza, G.L.},
 journal = {Coronary Artery Dispatch},
 note = {DA - 20050525 NOT IN FILE},
 number = {4},
 pages = {217-224},
 title = {Endovascular needle injection of cholesteryl linoleate into the arterial wall produces complex vascular lesions identifiable by intravascular ultrasound: {E}arly development in a porcine model of vulnerable plaque},
 volume = {16},
 year = {2005},
 keywords = {analysis, Animals, Arteriosclerosis, Biopsy, Needle, Cholesterol, Esters, Comparative, Study, Coronary, Vessels, Disease, Models, Animal, Iliac, Artery, Immunohistochemistry, Injections, Intra-Arterial, methods, pathology, Probability, Research, Support, Non-U.S.Gov't, Sensitivity, and, Specificity, Sus, scrofa, Tunica, Intima, ultrasonography, Ultrasonography, Interventional},
 title_with_no_special_chars = {Endovascular needle injection of cholesteryl linoleate into the arterial wall produces complex vascular lesions identifiable by intravascular ultrasound Early development in a porcine model of vulnerable plaque}
}

Website  abstract   bibtex   

@article{
 title = {A history of total mercury in edible muscle of fish from lakes in northern Canada.},
 type = {article},
 year = {2005},
 identifiers = {[object Object]},
 keywords = {Animals,Canada,Environmental Monitoring,Fishes,Food Contamination,Fresh Water,Geological Phenomena,Geology,Humans,Mercury,Mercury: analysis,Mercury: standards,Muscles,Muscles: chemistry,Risk Assessment,Water Pollutants, Chemical,Water Pollutants, Chemical: analysis,Water Pollutants, Chemical: standards},
 pages = {427-63},
 volume = {351-352},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16169059},
 month = {12},
 day = {1},
 id = {5871338c-f5be-3a03-8357-10e95e527458},
 created = {2012-01-11T20:00:37.000Z},
 accessed = {2011-10-01},
 file_attached = {true},
 profile_id = {1f6a330f-f6a3-36e6-abae-0954f070a071},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Lockhart2005a},
 private_publication = {false},
 abstract = {Subsistence fishing has been an important source of food for Native People in northern Canada since prehistoric time. Measurements of the levels of mercury in edible muscle of northern fish have been undertaken for over three decades in efforts to evaluate the risks of consuming northern fish. This report summarizes the data obtained from 7974 fish of 25 species from sites distributed from the Yukon to Labrador. The most abundant species were lake trout, lake whitefish, arctic char, walleye, northern pike and burbot. The question being asked was essentially "Are the fish safe to eat?" The results were used to support decisions on fishing and consumption of fish. They were sorted in several ways, into concentration ranges corresponding to human consumption guidelines, into political jurisdictions and into types of bedrock geology. Overall walleye, northern pike and lake trout, usually exceeded the subsistence consumption guideline of 0.2 microg g-1 total mercury and often exceeded the higher guideline of 0.5 microg g-1 total mercury for commercial sales of fish. Mercury in burbot, another facultative predator, was often lower but several still exceeding a guideline. Arctic char collections were mostly from anadromous populations and these had very low levels of mercury, presumably reflecting marine food sources. Lake whitefish were among the cleanest fish examined with 69 of 81 collections falling in the lowest range. Most collections were from sites in sedimentary rock. However a few sites were in metamorphic, intrusive or volcanic rocks and these, taken together, tended to have a higher proportion of sites in the higher ranges of mercury. These results indicate a widespread problem with mercury in subsistence fisheries for predator species of fish with the problem being most problematic for Nunavut.},
 bibtype = {article},
 author = {Lockhart, W L and Stern, G a and Low, G and Hendzel, M and Boila, G and Roach, P and Evans, M S and Billeck, B N and DeLaronde, J and Friesen, S and Kidd, K and Atkins, S and Muir, D C G and Stoddart, M and Stephens, G and Stephenson, S and Harbicht, S and Snowshoe, N and Grey, B and Thompson, S and DeGraff, N},
 journal = {The Science of the total environment}
}

@Article{Kurzban2005,
  author   = {Robert Kurzban and Daniel Houser},
  journal  = {Proc Natl Acad Sci U S A},
  title    = {Experiments investigating cooperative types in humans: {A} complement to evolutionary theory and simulations.},
  year     = {2005},
  number   = {5},
  pages    = {1803-7},
  volume   = {102},
  abstract = {Unlike other species, humans cooperate in large, distantly related
	groups, a fact that has long presented a puzzle to biologists. The
	pathway by which adaptations for large-scale cooperation among nonkin
	evolved in humans remains a subject of vigorous debate. Results from
	theoretical analyses and agent-based simulations suggest that evolutionary
	dynamics need not yield homogeneous populations, but can instead
	generate a polymorphic population that consists of individuals who
	vary in their degree of cooperativeness. These results resonate with
	the recent increasing emphasis on the importance of individual differences
	in understanding and modeling behavior and dynamics in experimental
	games and decision problems. Here, we report the results of laboratory
	experiments that complement both theory and simulation results. We
	find that our subjects fall into three types, an individual's type
	is stable, and a group's cooperative outcomes can be remarkably well
	predicted if one knows its type composition. Reciprocal types, who
	contribute to the public good as a positive function of their beliefs
	about others' contributions, constitute the majority (63\%) of players;
	cooperators and free-riders are also present in our subject population.
	Despite substantial behavioral differences, earnings among types
	are statistically identical. Our results support the view that our
	human subject population is in a stable, polymorphic equilibrium
	of types.},
  doi      = {10.1073/pnas.0408759102},
  keywords = {Agonistic Behavior, Animals, Anura, Behavior, Animal, Cues, Male, Research Support, Non-U.S. Gov't, U.S. Gov't, P.H.S., Vocalization, 15665099},
}

Paper  doi  abstract   bibtex   

@article{kitamura_comparative_2005,
	title = {Comparative study of the endocrine-disrupting activity of bisphenol {A} and 19 related compounds.},
	volume = {84},
	issn = {1096-6080},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15635150},
	doi = {10.1093/toxsci/kfi074},
	abstract = {The endocrine-disrupting activities of bisphenol A (BPA) and 19 related compounds were comparatively examined by means of different in vitro and in vivo reporter assays. BPA and some related compounds exhibited estrogenic activity in human breast cancer cell line MCF-7, but there were remarkable differences in activity. Tetrachlorobisphenol A (TCBPA) showed the highest activity, followed by bisphenol B, BPA, and tetramethylbisphenol A (TMBPA); 2,2-bis(4-hydroxyphenyl)-1-propanol, 1,1-bis(4-hydroxyphenyl)propionic acid and 2,2-diphenylpropane showed little or no activity. Anti-estrogenic activity against 17beta-estradiol was observed with TMBPA and tetrabromobisphenol A (TBBPA). TCBPA, TBBPA, and BPA gave positive responses in the in vivo uterotrophic assay using ovariectomized mice. In contrast, BPA and some related compounds showed significant inhibitory effects on the androgenic activity of 5alpha-dihydrotestosterone in mouse fibroblast cell line NIH3T3. TMBPA showed the highest antagonistic activity, followed by bisphenol AF, bisphenol AD, bisphenol B, and BPA. However, TBBPA, TCBPA, and 2,2-diphenylpropane were inactive. TBBPA, TCBPA, TMBPA, and 3,3'-dimethylbisphenol A exhibited significant thyroid hormonal activity towards rat pituitary cell line GH3, which releases growth hormone in a thyroid hormone-dependent manner. However, BPA and other derivatives did not show such activity. The results suggest that the 4-hydroxyl group of the A-phenyl ring and the B-phenyl ring of BPA derivatives are required for these hormonal activities, and substituents at the 3,5-positions of the phenyl rings and the bridging alkyl moiety markedly influence the activities.},
	number = {2},
	journal = {Toxicological sciences},
	author = {Kitamura, Shigeyuki and Suzuki, Tomoharu and Sanoh, Seigo and Kohta, Ryuki and Jinno, Norimasa and Sugihara, Kazumi and Yoshihara, Shin'ichi and Fujimoto, Nariaki and Watanabe, Hiromitsu and Ohta, Shigeru},
	month = apr,
	year = {2005},
	pmid = {15635150},
	keywords = {Air Pollutants, Animals, Breast Neoplasms, Breast Neoplasms: drug therapy, Breast Neoplasms: metabolism, Dose-Response Relationship, Drug, Estrogens, Female, Flame retardants, Growth Hormone, Growth Hormone: metabolism, Hormone Antagonists, Hormone Antagonists: chemistry, Hormone Antagonists: classification, Hormone Antagonists: toxicity, Humans, Mice, NIH 3T3 Cells, NIH 3T3 Cells: drug effects, NIH 3T3 Cells: metabolism, Non-Steroidal, Non-Steroidal: chemistry, Non-Steroidal: classification, Non-Steroidal: toxicity, Occupational, Occupational: toxicity, Phenols, Phenols: chemistry, Phenols: classification, Phenols: toxicity, Pituitary Gland, Pituitary Gland: drug effects, Pituitary Gland: metabolism, Structure-Activity Relationship, Tumor, cell line, frelec, tox},
	pages = {249--59},
}

Paper  doi  abstract   bibtex   

@article{Zupanc2005,
	title = {Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain.},
	volume = {488},
	issn = {0021-9967},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15952170},
	doi = {10.1002/cne.20571},
	abstract = {In contrast to mammals, fish exhibit an enormous potential to produce new cells in the adult brain. By labeling mitotically dividing cells with 5-bromo-2'-deoxyuridine (BrdU), we have characterized the development of these cells in the zebrafish (Danio rerio). Proliferation zones were located in specific regions of the olfactory bulb, dorsal telencephalon (including a region presumably homologous to the mammalian hippocampus), preoptic area, dorsal zone of the periventricular hypothalamus, optic tectum, torus longitudinalis, vagal lobe, parenchyma near the rhombencephalic ventricle, and in a region of the medulla oblongata lateral to the vagal motor nucleus, as well as in all three subdivisions of the cerebellum, the valvula cerebelli, the corpus cerebelli, and the lobus caudalis cerebelli. In the valvula cerebelli and the corpus cerebelli, the young cells migrated from their site of origin in the molecular layers to the corresponding granule cell layers. By contrast, in the lobus caudalis cerebelli and optic tectum, no indication of a migration of the newly generated cells over wider distances could be obtained. BrdU-labeled cells remained present in the brain over at least 292 days post-BrdU administration, indicating a long-term survival of a significant portion of the newly generated cells. The combination of BrdU immunohistochemistry with immunolabeling against the neural marker protein Hu, or with retrograde tracing, suggested a neuronal differentiation in a large portion of the young cells.},
	number = {3},
	urldate = {2013-08-16},
	journal = {The Journal of comparative neurology},
	author = {Zupanc, Günther K H and Hinsch, Karen and Gage, Fred H},
	month = aug,
	year = {2005},
	pmid = {15952170},
	keywords = {\#nosource, Animals, Brain, Brain Mapping, Brain: cytology, Bromodeoxyuridine, Bromodeoxyuridine: metabolism, Calcium-Binding Protein, Vitamin D-Dependent, Calcium-Binding Protein, Vitamin D-Dependent: meta, Cell Count, Cell Count: methods, Cell Differentiation, Cell Differentiation: physiology, Cell Movement, Cell Movement: physiology, Cell Proliferation, Cell Survival, Cell Survival: physiology, Glial Fibrillary Acidic Protein, Glial Fibrillary Acidic Protein: metabolism, Hu Paraneoplastic Encephalomyelitis Antigens, Immunohistochemistry, Immunohistochemistry: methods, Nerve Tissue Proteins, Nerve Tissue Proteins: metabolism, Neurons, Neurons: cytology, RNA-Binding Proteins, RNA-Binding Proteins: metabolism, S100 Proteins, S100 Proteins: metabolism, Time Factors, Zebrafish, Zebrafish: physiology},
	pages = {290--319},
}

@Article{Hartung_2005_994,
  author = {Hartung, D. and Sarai, M. and Petrov, A. and Kolodgie, F. and Narula, N. and Verjans, J. and Virmani, R. and Reutelingsperger, C. and Hofstra, L. and Narula, J.},
 journal = {J.Nucl.Med.},
 note = {DA - 20051206 NOT IN FILE},
 number = {12},
 pages = {2051-2056},
 title = {Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy},
 volume = {46},
 year = {2005},
 keywords = {Animal, Feed, Animals, Annexin, A5, Aorta, Apoptosis, Atherosclerosis, chemistry, Cholesterol, Coronary, Disease, drug, therapy, Female, Hydroxymethylglutaryl, CoA, Reductases, Hydroxymethylglutaryl-CoA, Reductase, Inhibitors, Immunohistochemistry, Incidence, Macrophages, Male, metabolism, methods, Mutation, pathology, pharmacokinetics, pharmacology, Rabbits, radionuclide, imaging, Recombinant, Proteins, Research, Support, N.I.H., Extramural, therapy},
 title_with_no_special_chars = {Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy}
}

Paper  Website  abstract   bibtex   

@article{
 title = {Contaminant levels in sediments and asteroids (Asterias rubens L., Echinodermata) from the Belgian coast and Scheldt estuary: polychlorinated biphenyls and heavy metals.},
 type = {article},
 year = {2004},
 identifiers = {[object Object]},
 keywords = {Animals,Environmental Monitoring,Environmental Pollutants,Environmental Pollutants: analysis,Environmental Pollutants: pharmacokinetics,Geologic Sediments,Geologic Sediments: chemistry,Metals, Heavy,Metals, Heavy: analysis,Metals, Heavy: pharmacokinetics,North Sea,Polychlorinated Biphenyls,Polychlorinated Biphenyls: analysis,Polychlorinated Biphenyls: pharmacokinetics,Starfish,Starfish: chemistry,Tissue Distribution},
 pages = {149-65},
 volume = {333},
 websites = {http://dx.doi.org/10.1016/j.scitotenv.2004.05.002},
 month = {10},
 id = {3e9d21fe-f6d2-3a7e-81ca-379c5d431faa},
 created = {2010-09-15T11:24:56.000Z},
 accessed = {2010-09-15},
 file_attached = {true},
 profile_id = {c6c6f844-18d2-32db-a619-2e915134a952},
 last_modified = {2017-03-31T08:27:57.360Z},
 read = {true},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Danis2004},
 folder_uuids = {a6bf1321-9beb-4f7c-9715-6ab10e069d78,25cad246-e846-4c62-92bf-3da69f6f5c57},
 abstract = {The Southern Bight of the North Sea is particularly exposed to anthropogenic contamination, due to heavy urbanisation and industrialisation of its catchment area. The present work focuses on polychlorinated biphenyl (PCB) and metal contamination of the marine environment along and off the Belgian coast. Its objectives were to compare the concentrations of seven PCB congeners and four heavy metals in the sediments (a repository for anthropogenic contaminants) and in the asteroid Asterias rubens (a recognized bioindicator species). Nineteen sampling stations were considered between the mouth of the Scheldt Estuary and the southern limit of the Belgian coast (asteroids were found in 10 out of the 19 stations). PCB and metal concentrations measured in sediments and asteroids were in the range of values reported in previous studies. Stations under direct influence of the Scheldt were the most impacted by the considered contaminants. Metal concentrations varied according to the grain-size fraction considered. In asteroids, PCBs and metals were found to be selectively distributed among body compartments, and pyloric caeca were found to most efficiently discriminate between sampling stations contamination levels. PCB and metal analysis of sediments provided a physicochemical evaluation of the contamination, whereas analysis of asteroids introduced a biological dimension to the approach by taking into account bioavailability of the contaminants.},
 bibtype = {article},
 author = {Danis, B and Wantier, P and Dutrieux, S and Flammang, R and Dubois, Ph and Warnau, M},
 journal = {The Science of the total environment},
 number = {1-3}
}

Paper  doi  abstract   bibtex   

@article{Ulrich2004,
	title = {{RNA} and {DNA} aptamers in cytomics analysis.},
	volume = {59},
	issn = {1552-4922},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15170601},
	doi = {10.1002/cyto.a.20056},
	abstract = {The systematic evolution of ligands by exponential enrichment (SELEX) technique is a combinatorial library approach in which DNA or RNA molecules (aptamers) are selected by their ability to bind their protein targets with high affinity and specificity, comparable to that of monoclonal antibodies. In contrast to antibodies conventionally selected in animals, aptamers are generated by an in vitro selection process, and can be directed against almost every target, including antigens like toxins or nonimmunogenic targets, against which conventional antibodies cannot be raised.},
	number = {2},
	journal = {Cytometry. Part A : the journal of the International Society for Analytical Cytology},
	author = {Ulrich, Henning and Martins, Antonio Henrique B and Pesquero, João Bosco},
	month = jun,
	year = {2004},
	pmid = {15170601},
	keywords = {\#nosource, Animals, Binding, Combinatorial Chemistry Techniques, Combinatorial Chemistry Techniques: methods, Competitive, DNA, DNA: chemistry, Flow Cytometry, Flow Cytometry: methods, Humans, Ligands, Proteins, Proteins: analysis, Proteins: chemistry, Proteins: physiology, Proteomics, Proteomics: methods, RNA, RNA: chemistry},
	pages = {220--31},
}

@Article{Backwell2004,
  author   = {Patricia R Y Backwell and Michael D Jennions},
  journal  = {Nature},
  title    = {Animal behaviour: {C}oalition among male fiddler crabs.},
  year     = {2004},
  number   = {6998},
  pages    = {417},
  volume   = {430},
  abstract = {Until now, no compelling evidence has emerged from studies of animal
	territoriality to indicate that a resident will strategically help
	a neighbour to defend its territory against an intruder. We show
	here that territory-owning Australian fiddler crabs will judiciously
	assist other crabs in defending their neighbouring territories. This
	cooperation supports the prediction that it is sometimes less costly
	to assist a familiar neighbour than to renegotiate boundaries with
	a new, and possibly stronger, neighbour.},
  doi      = {10.1038/430417a},
  keywords = {Animals, Attention, Brain, Decision Making, Face, Female, Haplorhini, Housing, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Pattern Recognition, Visual, Photic Stimulation, Prefrontal Cortex, Research Support, Non-U.S. Gov't, U.S. Gov't, P.H.S., Visual Perception, Choice Behavior, Cognition, Dopamine, Learning, Schizophrenia, Substance-Related Disorders, Generalization (Psychology), Motor Skills, Non-P.H.S., Nerve Net, Neuronal Plasticity, Perception, Cerebral Cortex, Memory, Neurons, Sound Localization, Synapses, Synaptic Transmission, Neural Pathways, Non-, Acoustic Stimulation, Adult, Age of Onset, Aging, Blindness, Child, Preschool, Infant, Newborn, Pitch Perception, Analysis of Variance, Animal Welfare, Laboratory, Behavior, Animal, Hybridization, Genetic, Maze Learning, Mice, Inbred C57BL, Inbred DBA, Phenotype, Reproducibility of Results, Darkness, Deafness, Finches, Sleep, Sound, Sunlight, Time Factors, Vocalization, Energy Metabolism, Evolution, Fossils, History, Ancient, Hominidae, Biological, Physical Endurance, Running, Skeleton, Walking, Acoustics, Auditory Perception, Cues, Discrimination Learning, Pair Bond, Social Behavior, Songbirds, Adolescent, England, Habituation (Psychophysiology), Korea, Language, Semantics, Vocabulary, Action Potentials, Hippocampus, Pyramidal Cells, Rats, Rotation, Australia, Brachyura, Cooperative Behavior, Logistic Models, Territoriality, 15269757},
}

@Article{Feinstein_2004_1104,
  author = {Feinstein, S.B.},
 journal = {American Journal of Physiology - Heart and Circulatory Physiology},
 note = {0363-6135 (Print) Historical Article Journal Article Review},
 number = {2},
 pages = {H450-457},
 title = {The powerful microbubble: {F}rom bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond},
 volume = {287},
 year = {2004},
 keywords = {Animals, Arteriosclerosis/*therapy/*ultrasonography, Blood, Vessels/*ultrasonography, Carotid, Stenosis/complications/ultrasonography, Decompression, Sickness/ultrasonography, *Diffusion, of, Innovation, Echocardiography, History, 20th, Century, Humans, *Microbubbles, Neovascularization, Pathologic/etiology/ultrasonography, Ultrasonography/history},
 title_with_no_special_chars = {The powerful microbubble From bench to bedside from intravascular indicator to therapeutic delivery system and beyond}
}

Paper  doi  abstract   bibtex   

@article{Jacquemard2004,
	title = {Synthesis of diphenylcarbazoles as cytotoxic {DNA} binding agents.},
	volume = {2},
	issn = {1477-0520},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15136803},
	doi = {10.1039/b401445f},
	abstract = {We report the synthesis of a series of novel diphenylcarbazoles designed to interact with DNA. The compounds bearing two or three dimethylaminoalkyloxy side chains were found to bind much more tightly to DNA, preferentially at AT-rich sites, than the corresponding hydroxy compounds. The DNA binding compounds exhibit potent cytotoxic activity toward P388 leukemia cells. The 3,6-diphenylcarbazole thus represent an interesting scaffold to develop antitumor agents interacting with nucleic acids.},
	number = {10},
	journal = {Organic \& biomolecular chemistry},
	author = {Jacquemard, Ulrich and Routier, Sylvain and Tatibouët, Arnaud and Kluza, Jérôme and Laine, William and Bal, Christine and Bailly, Christian and Mérour, Jean-Yves},
	month = may,
	year = {2004},
	pmid = {15136803},
	keywords = {\#nosource, Alkylation, Animals, Antineoplastic Agents, Antineoplastic Agents: chemical synthesis, Antineoplastic Agents: chemistry, Antineoplastic Agents: pharmacology, Apoptosis, Apoptosis: drug effects, Benzene Derivatives, Benzene Derivatives: chemical synthesis, Benzene Derivatives: chemistry, Benzene Derivatives: pharmacology, Carbazoles, Carbazoles: chemical synthesis, Carbazoles: chemistry, Cell Cycle, Cell Cycle: drug effects, Cell Division, Cell Division: drug effects, Cell Line, DNA, DNA: chemistry, Flow Cytometry, Heterocyclic Compounds with 4 or More Rings, Heterocyclic Compounds with 4 or More Rings: chemi, Heterocyclic Compounds with 4 or More Rings: pharm, Inhibitory Concentration 50, Magnetic Resonance Spectroscopy, Mice, Molecular Structure, Poly dA-dT, Poly dA-dT: chemistry, Structure-Activity Relationship, Transition Temperature, Transition Temperature: drug effects, Tumor},
	pages = {1476--83},
}

@article{ santarelli_requirement_2003,
  title = {Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants},
  volume = {301},
  issn = {1095-9203},
  doi = {10.1126/science.1083328},
  abstract = {Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.},
  language = {eng},
  number = {5634},
  journal = {Science (New York, N.Y.)},
  author = {Santarelli, Luca and Saxe, Michael and Gross, Cornelius and Surget, Alexandre and Battaglia, Fortunato and Dulawa, Stephanie and Weisstaub, Noelia and Lee, James and Duman, Ronald and Arancio, Ottavio and Belzung, Catherine and Hen, René},
  month = {August},
  year = {2003},
  pmid = {12907793},
  keywords = {8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Antidepressive Agents, Antidepressive Agents, Second-Generation, Antidepressive Agents, Tricyclic, Behavior, Animal, Cell Division, Conditioning (Psychology), Dentate Gyrus, Fear, Feeding Behavior, Fluoxetine, Grooming, Hippocampus, Long-Term Potentiation, Male, Mice, Mice, Knockout, Neurons, Receptors, Serotonin, Receptors, Serotonin, 5-{HT}1, Stress, Physiological, Synaptic Transmission},
  pages = {805--809}
}

@article{moore_selective_2003,
	title = {Selective gating of visual signals by microstimulation of frontal cortex.},
	volume = {421},
	doi = {10.1038/nature01341},
	abstract = {Several decades of psychophysical and neurophysiological studies have established that visual signals are enhanced at the locus of attention. What remains a mystery is the mechanism that initiates biases in the strength of visual representations. Recent evidence argues that, during spatial attention, these biases reflect nascent saccadic eye movement commands. We examined the functional interaction of saccade preparation and visual coding by electrically stimulating sites within the frontal eye fields (FEF) and measuring its effect on the activity of neurons in extrastriate visual cortex. Here we show that visual responses in area V4 could be enhanced after brief stimulation of retinotopically corresponding sites within the FEF using currents below that needed to evoke saccades. The magnitude of the enhancement depended on the effectiveness of receptive field stimuli as well as on the presence of competing stimuli outside the receptive field. Stimulation of non-corresponding FEF representations could suppress V4 responses. The results suggest that the gain of visual signals is modified according to the strength of spatially corresponding eye movement commands.},
	language = {eng},
	number = {6921},
	journal = {Nature},
	author = {Moore, Tirin and Armstrong, Katherine M},
	year = {2003},
	pmid = {12540901},
	note = {Place: England
ISBN: 0028-0836},
	keywords = {Analysis of Variance, Animals, Fixation, Ocular, Frontal Lobe, Haplorhini, MicroValence, Neurons, Photic Stimulation, Saccades, Visual Cortex, Visual Perception, research support, non-u.s. gov't, research support, u.s. gov't, p.h.s.},
	pages = {370--373},
}

@article{witczak_thio-sugars_2003,
	title = {Thio-sugars {VII}. {Effect} of 3-deoxy-4-{S}-(beta-{D}-gluco- and beta-{D}-galactopyranosyl)-4-thiodisaccharides and their sulfoxides and sulfones on the viability and growth of selected murine and human tumor cell lines},
	volume = {338},
	issn = {0008-6215},
	abstract = {The first conversion of (1--{\textgreater}4)-thiodisaccharides into corresponding sulfoxides and sulfones by conventional oxidation with m-chloroperoxybenzoic acid (MCPBA) is reported. The effects of alpha-(1--{\textgreater}4)-3'-deoxythiodisaccharides (8-9) and their sulfoxide (14-15) and sulfone (16-17) derivatives on murine leukemia and human colon and pancreatic carcinoma cell viability were studied. Concentrations of thio-sugars that decreased tumor cell line viability by 50\% (IC(50)), measured via the MTT assay, ranged from 6.4 to 38.3 microg/mL. The effect of alpha-(1--{\textgreater}4)-3'-deoxythiodisaccharide derivatives were most profound on human pancreatic epithelial carcinoma (PANC-1) cells with compounds 8 and 9 having IC(50) values of 6.4 microg/mL and 8.2 microg/mL, respectively. Sulfone derivatives 16 and 17 also had pronounced effects on PANC-1 cell viability (IC(50)=10.2 microg/mL and 9.6 microg/mL, respectively). These results indicate that deoxythio-disaccharide analogs generated by functionalization of the universal chiral precursor levoglucosenone may have cytotoxic properties and therapeutic potential as anticancer agents.},
	language = {eng},
	number = {1},
	journal = {Carbohydrate Research},
	author = {Witczak, Zbigniew J. and Kaplon, Peter and Dey, P. Markus},
	month = jan,
	year = {2003},
	pmid = {12504376},
	keywords = {Animals, Antineoplastic Agents, Carbohydrates, Cell Division, Cell Survival, Humans, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Sulfhydryl Compounds, Sulfones, Sulfoxides, Tumor Cells, Cultured},
	pages = {11--18},
}

@Article{Antonov2003,
  author   = {Igor Antonov and Irina Antonova and Eric R Kandel and Robert D Hawkins},
  journal  = {Neuron},
  title    = {Activity-dependent presynaptic facilitation and hebbian {LTP} are both required and interact during classical conditioning in {A}plysia.},
  year     = {2003},
  number   = {1},
  pages    = {135-47},
  volume   = {37},
  abstract = {Using a simplified preparation of the Aplysia siphon-withdrawal reflex,
	we previously found that associative plasticity at synapses between
	sensory neurons and motor neurons contributes importantly to classical
	conditioning of the reflex. We have now tested the roles in that
	plasticity of two associative cellular mechanisms: activity-dependent
	enhancement of presynaptic facilitation and postsynaptically induced
	long-term potentiation. By perturbing molecular signaling pathways
	in individual neurons, we have provided the most direct evidence
	to date that each of these mechanisms contributes to behavioral learning.
	In addition, our results suggest that the two mechanisms are not
	independent but rather interact through retrograde signaling.},
  keywords = {Amygdala, Animals, Evaluation Studies, Hippocampus, Human, Learning, Long-Term Potentiation, Memory, Models, Neurological, Neural Pathways, Neuronal Plasticity, Support, Non-U.S. Gov't, Synapses, 2-Amino-5-phosphonovalerate, Electric Stimulation, Isomerism, Rats, Receptors, N-Methyl-D-Aspartate, Neurotransmitter, Valine, Visual Perception, Action Potentials, Calcium Signaling, Central Nervous System, Chelating Agents, Conditioning (Psychology), Cyclic AMP-Dependent Protein Kinases, Enzyme Inhibitors, Excitatory Amino Acid Antagonists, Motor Neurons, Neurons, Afferent, Reaction Time, Reflex, Signal Transduction, U.S. Gov't, P.H.S., Synaptic Transmission, 12526779},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Grandmothers and the Evolution of Human Longevity},
 type = {article},
 year = {2003},
 identifiers = {[object Object]},
 keywords = {*Evolution,*Family,*Longevity,Aging,Animals,Biological,Humans,Models,Pan troglodytes},
 pages = {380-400},
 volume = {15},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12704714},
 edition = {2003/04/22},
 id = {48b60b26-ce0d-3210-90d4-f3cd1e798e69},
 created = {2017-06-19T13:41:50.765Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:41:50.891Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>        <m:bold>From Duplicate 1 ( </m:bold>        <m:bold>          </m:bold><m:bold><m:italic>Grandmothers and the evolution of human longevity</m:italic></m:bold><m:bold>        </m:bold>        <m:bold> - Hawkes, K )<m:linebreak/>        </m:bold>        <m:linebreak/>Hawkes, Kristen<m:linebreak/>Review<m:linebreak/>United States<m:linebreak/>American journal of human biology : the official journal of the Human Biology Council<m:linebreak/>Am J Hum Biol. 2003 May-Jun;15(3):380-400.<m:linebreak/>        <m:linebreak/>      </m:note>},
 abstract = {ABSTRACT Great apes, our closest living relatives, live longer and mature later than most other mammals and modern humans are even later-maturing and potentially longer-lived. Evolutionary life-history theory seeks to explain cross-species differences in these variables and the covariation between them. That provides the foundation for a hypothesis that a novel role for grandmothers underlies the shift from an ape-like ancestral pattern to one more like our own in the first widely successful members of genus Homo. This hypothesis links four distinctive features of human life histories: 1) our potential longevity, 2) our late maturity, 3) our midlife menopause, and 4) our early weaning with next offspring produced before the previous infant can feed itself. I discuss the problem, then, using modern humans and chimpanzees to represent, respectively, genus Homo and australopithecines, I focus on two corollaries of this grandmother hypothesis: 1) that ancestral age-specific fertility declines persisted in our genus, while 2) senescence in other aspects of physiological performance slowed down. The data are scanty but they illustrate similarities in age-specific fertility decline and differences in somatic durability that are consist- ent with the hypothesis that increased longevity in our genus is a legacy of the ‘‘reproductive’’ role of ancestral grandmothers},
 bibtype = {article},
 author = {Hawkes, Kristen},
 journal = {American journal of human biology},
 number = {3}
}

@article{taylor_theileria_2002,
	title = {Theileria annulata: virulence and transmission from single and mixed clone infections in cattle.},
	volume = {100},
	issn = {0014-4894 0014-4894},
	abstract = {Theoretically, parasite virulence should be higher for faster growing parasites,  and higher in mixed infections compared to single-clone infections. Virulence should also be positively correlated to transmission rates. Theileria annulata provides a good model system for studying such hypotheses, as parasite replication causes harm to the host, and there is evidence suggesting that the genetic complexity of an infection might affect its virulence. Two clones of T. annulata were chosen, one fast growing and one slow growing in vitro and these were used to establish cattle infections, either alone, or in a mixed infection.  Virulence was measured using lymph node expansion, temperature, and blood parameters as correlates. As predicted, the faster growing clone was found to produce higher virulence. Mixed infections did not show higher virulence than single-clone infections, but interactions within mixed infections resulted in more transmission stage production than seen in either of the single-clone infections. Index Descriptors and Abbreviations. Theileria annulata, Apicomplexa, mixed infections, virulence, growth rates, red blood cell, RBC; packed cell volume, PCV.},
	language = {eng},
	number = {3},
	journal = {Experimental parasitology},
	author = {Taylor, Louise H. and Welburn, Sue C. and Woolhouse, Mark E. J.},
	month = mar,
	year = {2002},
	pmid = {12173404},
	keywords = {Animals, Cattle, Erythrocyte Count, Genotype, Host-Parasite Interactions, Leukocyte Count, Male, Parasitemia/parasitology, Theileria annulata/classification/genetics/growth \& development/*pathogenicity, Theileriasis/*parasitology/*transmission, Virulence},
	pages = {186--195}
}

@article{chetkovich_postsynaptic_2002,
	title = {Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms},
	volume = {22},
	issn = {1529-2401},
	doi = {20026598},
	abstract = {Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs including PDZ (postsynaptic density-95/Discs large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and plasticity at excitatory synapses. We report that N-terminal alternative splicing of PSD95 generates an isoform, PSD95beta that contains an additional "L27" motif, which is also present in SAP97. Using yeast two hybrid and coimmunoprecipitation assays, we demonstrate that this N-terminal L27 domain of PSD-95beta, binds to an L27 domain in the membrane-associated guanylate kinase calcium/calmodulin-dependent serine kinase, and to Hrs, an endosomal ATPase that regulates vesicular trafficking. By transfecting heterologous cells and hippocampal neurons, we find that interactions with the L27 domain regulate synaptic clustering of PSD95beta. Disrupting Hrs-regulated early endosomal sorting in hippocampal neurons selectively blocks synaptic clustering of PSD95beta but does not interfere with trafficking of the palmitoylated isoform, PSD95alpha. These studies identify molecular and functional heterogeneity in synaptic PSD95 complexes and reveal critical roles for L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering.},
	language = {eng},
	number = {15},
	journal = {The Journal of Neuroscience: The Official Journal of the Society for Neuroscience},
	author = {Chetkovich, Dane M. and Bunn, Robert C. and Kuo, Sheng-Han and Kawasaki, Yoshimi and Kohwi, Minoree and Bredt, David S.},
	month = aug,
	year = {2002},
	pmid = {12151521},
	pmcid = {PMC6758133},
	keywords = {Adaptor Proteins, Signal Transducing, Alternative Splicing, Amino Acid Motifs, Animals, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cells, Cultured, Disks Large Homolog 4 Protein, Endosomal Sorting Complexes Required for Transport, Guanylate Kinases, Humans, Intracellular Signaling Peptides and Proteins, Macromolecular Substances, Membrane Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Nucleoside-Phosphate Kinase, Phosphoproteins, Precipitin Tests, Protein Isoforms, Protein Structure, Tertiary, Protein Transport, Rats, Rodentia, Sequence Homology, Amino Acid, Synapses, Two-Hybrid System Techniques},
	pages = {6415--6425},
}

@Article{Peake2002,
  author   = {TM Peake and A M R Terry and PK McGregor and T Dabelsteen},
  journal  = {Proc R Soc Lond B Biol Sci},
  title    = {Do great tits assess rivals by combining direct experience with information gathered by eavesdropping?},
  year     = {2002},
  number   = {1503},
  pages    = {1925-9},
  volume   = {269},
  abstract = {Animals frequently use signals that travel further than the spacing
	between individuals. For every intended recipient of a given signal
	there are likely to be many other individuals that receive information.
	Eavesdropping on signalling interactions between other individuals
	provides a relatively cost-free method of assessing future opponents
	or mates. Male great tits (Parus major) extract relative information
	from such interactions between individuals unknown to them. Here,
	we show that male great tits can take information gathering a stage
	further and obtain more information about a previously unencountered
	intruder, by the hitherto unknown capability of combining information
	gathered by eavesdropping with that derived from their own direct
	interaction with an individual. Prior experience with an intruder
	(A) was achieved by subjecting a focal male to different levels of
	intrusion simulated using interactive playback. This intruder (A)
	then took part in a simulated interaction with an unknown male (B)
	outside the territorial boundary of the focal males. In response
	to subsequent intrusion by the second male (B), focal males showed
	low song output in response to males that had lost to a male that
	the subject was able to beat. Males of known high quality, or those
	about which information was ambiguous, elicited a high level of song
	output by focal males. We discuss the implications of this finding
	for the evolution of communication and social behaviour.},
  doi      = {10.1098/rspb.2002.2112},
  keywords = {Aggression, Animal Communication, Animals, Male, Research Support, Non-U.S. Gov't, Songbirds, Territoriality, Vocalization, Animal, 12350255},
}

@Article{Fayad_2002_1428,
  author = {Fayad, Z. A.},
 journal = {Neuroimaging Clin.N.Am.},
 note = {DA - 20021218 NOT IN FILE},
 number = {3},
 pages = {461-471},
 title = {Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI},
 volume = {12},
 year = {2002},
 keywords = {Animals, Arteries, Arteriosclerosis, Atherosclerosis, Contrast, Media, Coronary, Arteriosclerosis, Coronary, Vessels, diagnosis, Disease, Progression, Humans, Magnetic, Resonance, Angiography, Magnetic, Resonance, Imaging, methods, pathology, Research, Support, Non-U.S.Gov't, Research, Support, U.S.Gov't, P.H.S., Rupture, therapy},
 title_with_no_special_chars = {Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI}
}

@Article{Taylor2002,
  author   = {Dawn M Taylor and Stephen I Helms Tillery and Andrew B Schwartz},
  journal  = {Science},
  title    = {Direct cortical control of 3{D} neuroprosthetic devices.},
  year     = {2002},
  number   = {5574},
  pages    = {1829-32},
  volume   = {296},
  abstract = {Three-dimensional (3D) movement of neuroprosthetic devices can be
	controlled by the activity of cortical neurons when appropriate algorithms
	are used to decode intended movement in real time. Previous studies
	assumed that neurons maintain fixed tuning properties, and the studies
	used subjects who were unaware of the movements predicted by their
	recorded units. In this study, subjects had real-time visual feedback
	of their brain-controlled trajectories. Cell tuning properties changed
	when used for brain-controlled movements. By using control algorithms
	that track these changes, subjects made long sequences of 3D movements
	using far fewer cortical units than expected. Daily practice improved
	movement accuracy and the directional tuning of these units.},
  doi      = {10.1126/science.1070291},
  keywords = {Algorithms, Animals, Arm, Computer Simulation, Hand, Humans, Learning, Macaca mulatta, Motor Cortex, Motor Neurons, Movement, Non-U.S. Gov't, P.H.S., Prostheses and Implants, Research Support, U.S. Gov't, User-Computer Interface, Visual Perception, 12052943},
}

@Article{Sparre_2002_1402,
  author = {Sparre, T. and Christensen, U. B. and Mose Larsen, P. and Fey, S. J. and Wrzesinski, K. and Roepstorff, P. and Mandrup-Poulsen, T. and Pociot, F. and Karlsen, A. E. and Nerup, J.},
 journal = {Diabetologia},
 note = {Comparative Study Journal Article Research Support, Non-U.S. Gov't Germany},
 number = {11},
 pages = {1550-61},
 title = {Il-1beta induced protein changes in diabetes prone BB rat islets of langerhans identified by proteome analysis},
 volume = {45},
 year = {2002},
 keywords = {Animals, Animals, Newborn, Cells, Cultured, Diabetes, Mellitus, Type, 1/*genetics, Electrophoresis, Gel, Two-Dimensional, Enzymes/genetics, Interleukin-1/*pharmacology, Islets, of, Langerhans/cytology/drug, effects/*physiology, Proteins/*genetics/isolation, &, purification, *Proteome, Rats, Rats, Inbred, BB, Rats, Inbred, WF},
 title_with_no_special_chars = {IL1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis}
}

Website  abstract   bibtex   

@article{
 title = {Wading birds as bioindicators of mercury contamination in Florida, USA: annual and geographic variation},
 type = {article},
 year = {2002},
 identifiers = {[object Object]},
 keywords = {Animals,Birds,Birds: metabolism,Chemical,Chemical: pharmacokinetics,Environmental Monitoring,Feathers,Feathers: chemistry,Florida,Mercury,Mercury: pharmacokinetics,Seasons,Water Pollutants},
 pages = {163-167},
 volume = {21},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11804050},
 month = {1},
 id = {e77d144b-cfc5-3537-a451-e79c547bc230},
 created = {2013-06-11T17:24:40.000Z},
 file_attached = {true},
 profile_id = {641521c1-b61a-3102-87ce-59623ed647a8},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-11-14T18:05:36.965Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 folder_uuids = {c0133640-9fb9-42e9-81a6-3e93281754e2},
 private_publication = {false},
 abstract = {Mercury contamination in wetland biota is often dynamic, difficult to predict, and costly to track. In this paper, we present results from a six-year study of growing feathers of piscivorous birds as monitors of wetland Hg exposure in Florida, USA, wetlands. Between 1994 and 2000, we collected feathers of growing great egret (Ardea alba) nestlings from colonies in the freshwater Everglades of southern Florida, and during 1998, feathers were collected from chicks of both great egrets and white ibises (Eudocimus albus) at a variety of colonies throughout peninsular Florida. Coastal colonies showed significantly lower feather Hg concentrations than did inland sites. Within the Everglades, we found significant effects of both geographic location and year on age-adjusted mean total Hg concentrations in feathers. Over the course of our study, Everglades colonies maintained their Hg concentration rankings relative to one another, but all showed strongly declining Hg concentrations (mean of 73% averaged across colonies, between 1994 and 2000). Using a previously established predictive relationship between Hg consumption in food and feather Hg for great egrets, we estimated that Hg concentrations in the aggregate diet of egrets have been reduced by an average of 67%. We conclude that the Everglades has undergone a biologically significant decline in Hg availability in the wetland food web, possibly because of decreased local inputs.},
 bibtype = {article},
 author = {Frederick, Peter C. and Spalding, Marilyn G. and Dusek, Robert},
 journal = {Environmental Toxicology and Chemistry},
 number = {1}
}

Paper  abstract   bibtex   

@article{
 title = {Middle temporal visual area microstimulation influences veridical judgments of motion direction},
 type = {article},
 year = {2002},
 keywords = {Algorithms,Animals,Brain Mapping,Electric Stimulation/methods,Fixation, Ocular/physiology,Judgment/physiology,Macaca mulatta,Microelectrodes,Models, Neurological,Motion Perception/physiology,Neurons/physiology,Photic Stimulation/methods,Reproducibility of Results,Saccades/physiology,Temporal Lobe/physiology,Visual Cortex/physiology},
 pages = {9530-9540},
 volume = {22},
 id = {997a2ff5-1369-36ff-8481-66f744bb339a},
 created = {2017-09-01T15:54:30.239Z},
 file_attached = {true},
 profile_id = {80da7853-f7b7-36a9-8e4c-d7ddb2d9e538},
 group_id = {a2333ea3-15a4-3d40-8d36-f0d9590ca926},
 last_modified = {2017-09-01T15:54:30.352Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 language = {eng},
 abstract = {Microstimulation of direction columns in the middle temporal visual area (MT, or V5) provides a powerful tool for probing the relationship between cortical physiology and visual motion perception. In the current study we obtained "veridical" reports of perceived motion from rhesus monkeys by permitting a continuous range of possible responses that mapped isomorphically onto a continuous range of possible motion directions. In contrast to previous studies, therefore, the animals were freed from experimenter-imposed "categories" that typify forced choice tasks. We report three new findings: (1) MT neurons with widely disparate preferred directions can cooperate to shape direction estimates, inconsistent with a pure "winner-take-all" read-out algorithm and consistent with a distributed coding scheme like vector averaging, whereas neurons with nearly opposite preferred directions seem to compete in a manner consistent with the winner-take-all hypothesis, (2) microstimulation can influence direction estimates even when paired with the most powerful motion stimuli available, and (3) microstimulation effects can be elicited when a manual response (instead of our standard oculomotor response) is used to communicate the perceptual report.},
 bibtype = {article},
 author = {Nichols, M. and Newsome, William},
 number = {21}
}

@article{coleman_endemic_2001,
	title = {Endemic stability--a veterinary idea applied to human public health.},
	volume = {357},
	issn = {0140-6736 0140-6736},
	abstract = {Endemic stability is an epidemiological state of a population, in which clinical  disease is scarce despite high level of infection. The notion was developed to describe patterns of tick-borne disease in cattle. However, we propose a general  model of endemic stability that is applicable to a broader range of diseases that are important in public health, including malaria, rubella, and mumps. We postulate that endemic stability requires only that (1) the probability, or severity, of clinical disease after infection increases with age, and (2) after one infection, the probability that subsequent infections result in disease is reduced. We present these criteria in simple mathematical terms. Our hypothesis predicts that partial disease control activities might, under certain circumstances, lead to an increase in disease incidence. We discuss the implications for public health interventions.},
	language = {eng},
	number = {9264},
	journal = {Lancet (London, England)},
	author = {Coleman, P. G. and Perry, B. D. and Woolhouse, M. E.},
	month = apr,
	year = {2001},
	pmid = {11418173},
	keywords = {*Endemic Diseases, *Epidemiologic Methods, *Models, Theoretical, *Public Health, Age Distribution, Animals, Child, Preschool, Communicable Diseases/*epidemiology/etiology, Humans, Incidence, Infant, Infant, Newborn},
	pages = {1284--1286}
}

Paper  doi  abstract   bibtex   

@article{steiniger_perifollicular_2001,
	title = {The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?},
	volume = {159},
	issn = {0002-9440},
	shorttitle = {The perifollicular and marginal zones of the human splenic white pulp},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11485909},
	doi = {10.1016/S0002-9440(10)61722-1},
	abstract = {We investigate the white pulp compartments of 73 human spleens and demonstrate that there are several microanatomical peculiarities in man that do not occur in rats or mice. Humans lack a marginal sinus separating the marginal zone (MZ) from the follicles or the follicular mantle zone. The MZ is divided into an inner and an outer compartment by a special type of fibroblasts. An additional compartment, termed the perifollicular zone, is present between the follicular MZ and the red pulp. The perifollicular zone contains sheathed capillaries and blood-filled spaces without endothelial lining. In the perifollicular zone, in the outer MZ, and in the T cell zone fibroblasts of an unusual phenotype occur. These cells stain for the adhesion molecules MAdCAM-1, VCAM-1 (CD106), and VAP-1; the Thy-1 (CD90) molecule; smooth muscle alpha-actin and smooth muscle myosin; cytokeratin 18; and thrombomodulin (CD141). They are, however, negative for the peripheral node addressin, the cutaneous lymphocyte antigen, CD34, PECAM-1 (CD31), and P- and E-selectin (CD62P and CD62E). In the MZ the fibroblasts are often tightly associated with CD4-positive T lymphocytes, whereas CD8-positive cells are almost absent. Our findings lead to the hypothesis, that recirculating CD4-positive T lymphocytes enter the human splenic white pulp from the open circulation of the perifollicular zone without crossing an endothelium. Specialized fibroblasts may attract these T cells and guide them into the periarteriolar T cell area.},
	number = {2},
	urldate = {2012-03-26},
	journal = {The American Journal of Pathology},
	author = {Steiniger, B and Barth, P and Hellinger, A},
	month = aug,
	year = {2001},
	pmid = {11485909},
	keywords = {Actins, Adult, Animals, Antigens, CD, Biological Markers, Cell Adhesion Molecules, Female, Fibroblasts, Humans, Keratins, Lymphocytes, Male, Mice, Myosins, Rats, Spleen, Splenectomy},
	pages = {501--512},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Determination of dioxins/furans and PCBs by quadrupole ion-trap gas chromatography-mass spectrometry.},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Animals,Furans,Furans: analysis,Furans: toxicity,Gas Chromatography-Mass Spectrometry,Gas Chromatography-Mass Spectrometry: instrumentat,Gas Chromatography-Mass Spectrometry: methods,Humans,Polychlorinated Biphenyls,Polychlorinated Biphenyls: analysis,Polychlorinated Biphenyls: toxicity,Tetrachlorodibenzodioxin,Tetrachlorodibenzodioxin: analogs & derivatives,Tetrachlorodibenzodioxin: analysis,Tetrachlorodibenzodioxin: toxicity},
 pages = {305-65},
 volume = {19},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11079247},
 id = {99906347-4120-3a61-9bc4-5bb2ae3a2e80},
 created = {2014-05-31T04:14:15.000Z},
 file_attached = {true},
 profile_id = {9edae5ec-3a23-3830-8934-2c27bef6ccbe},
 group_id = {63e349d6-2c70-3938-9e67-2f6483f6cbab},
 last_modified = {2014-11-19T06:02:42.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {The versatility and sensitivity of the quadrupole ion trap tandem mass spectrometer has been applied to the determination of polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs), and of polychlorinated biphenyls (PCBs). A brief introduction to the theory of ion confinement in a quadrupole ion trap permits discussion of ion trajectory stability, mass-selective ion ejection, the frequencies of ion motion, and the role of resonant excitation of ion motion. The tandem mass spectrometric examination of PCDDs and PCDFs eluting and co-eluting from a gas chromatographic column is described. Illustrative examples are given of the analysis of field samples containing PCDDs and PCDFs. A comparison is presented of the performance of each of a quadrupole ion trap tandem mass spectrometer, a triple stage quadrupole mass spectrometer, and a sector instrument of relatively high mass resolution for the determination of PCDDs and PCDFs. This comparison is made with respect to instrument tuning, calibration plots, detection limits, ion signals at low concentration, relative response factors, ionization cross-sections, and the examination of field samples. The application of quadrupole ion trap tandem mass spectrometry to the examination of PCBs is focused upon those PCB congeners that have the greatest toxicity. 39 congeners of the total of 209 PCB congeners have been identified as having the greatest toxicities. Chemical ionization has been used for the determination of co-eluting congeners #77 and #110 where the toxicity of the former is much greater than that of the latter. An analytical protocol, based on the variation of molecular ion fragmentation according to the degree (or absence) of chlorine ortho-substitution, has been proposed for distinguishing between toxic and nontoxic PCB congeners.},
 bibtype = {article},
 author = {Plomley, J B and Lausevic, M and March, R E},
 journal = {Mass spectrometry reviews},
 number = {5}
}

@article{
 title = {In vivo penetration of experimentally produced clots by monoclonal antibodies},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Animals,Antibodies, Monoclonal/metabolism,Antibody Specificity,Autoradiography,Blood Coagulation/immunology,Disease Models, Animal,Fibrin/immunology,Fluorescent Antibody Technique,Humans,Immunoglobulin G/metabolism,Iodine Radioisotopes/diagnostic use,Jugular Veins/pathology,Phlebography,Protein Binding,Rabbits,Saphenous Vein/pathology,Sheep,Thrombosis/immunology/radiography,Time Factors},
 pages = {882-886},
 volume = {83},
 month = {6},
 city = {Royal Veterinary College, Hatfield, UK. f.mcevoy@swipnet.se},
 id = {e17cc696-c7cd-3a2f-822a-fbb9eea6c336},
 created = {2016-09-06T13:34:39.000Z},
 file_attached = {false},
 profile_id = {cacab941-be62-3845-982b-a7700857a11d},
 last_modified = {2016-09-07T14:54:39.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 notes = {LR: 20041117; PUBM: Print; JID: 7608063; 0 (Antibodies, Monoclonal); 0 (Immunoglobulin G); 0 (Iodine Radioisotopes); 9001-31-4 (Fibrin); ppublish},
 abstract = {Antifibrin monoclonal antibodies show potential as clot targeting agents for diagnosis and possibly therapy in thrombotic disease. To be effective the antibody must bind to the fibrin component of the clot. The ability of two antifibrin mabs (NIB 1H10 and NIB 12B3) to penetrate occlusive clots in vivo was investigated. Both mabs react with human fibrin but not with human fibrinogen nor with the fibrin or fibrinogen from the species used in this study. Two heterologous animal (sheep and rabbit) thrombus models were used. Clots in both cases were made within isolated vein segments using a mixture of human and native fibrinogen. The clots in sheep veins were observed radiographically and found to be occlusive for a mean of 4.2 +/- 2.2 days and thereafter appeared only partially occlusive. When targeted in their occlusive phase (131)I labelled mab accumulated in the clot reaching a maximum ratio of 1.82 +/- 0.42 when compared to counts in homologous sheep clots in the contralateral limb. It was confirmed in the rabbit jugular vein model that total occlusivity did not prevent antibody accumulation in the heterologous clot by injecting the fibrin specific mab 1H10 and examining the clot excised after 1, 6 and 24 h using immunofluorescence. In a further series of similar experiments (125)I labelled mab 1H10 was used and detected using autoradiography. Both sets of experiments indicated that penetration of occlusive clots by the antibody occurred and that considerable accumulation was present at 6 and 24 h. The results indicate that a circulating antibody can readily gain access to experimentally produced clots in occluded veins.},
 bibtype = {article},
 author = {McEvoy, F J and Edgell, T A and Webbon, P M and Gaffney, P J},
 journal = {Thrombosis and haemostasis},
 number = {6}
}

@Article{Thoroughman2000,
  author   = {KA Thoroughman and R Shadmehr},
  journal  = {Nature},
  title    = {Learning of action through adaptive combination of motor primitives.},
  year     = {2000},
  number   = {6805},
  pages    = {742-7},
  volume   = {407},
  abstract = {Understanding how the brain constructs movements remains a fundamental
	challenge in neuroscience. The brain may control complex movements
	through flexible combination of motor primitives, where each primitive
	is an element of computation in the sensorimotor map that transforms
	desired limb trajectories into motor commands. Theoretical studies
	have shown that a system's ability to learn action depends on the
	shape of its primitives. Using a time-series analysis of error patterns,
	here we show that humans learn the dynamics of reaching movements
	through a flexible combination of primitives that have gaussian-like
	tuning functions encoding hand velocity. The wide tuning of the inferred
	primitives predicts limitations on the brain's ability to represent
	viscous dynamics. We find close agreement between the predicted limitations
	and the subjects' adaptation to new force fields. The mathematical
	properties of the derived primitives resemble the tuning curves of
	Purkinje cells in the cerebellum. The activity of these cells may
	encode primitives that underlie the learning of dynamics.},
  doi      = {10.1038/35037588},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, 11048700},
}

Paper  Website  bibtex   

@article{
 title = {Single-particle electron cryo-microscopy: towards atomic resolution.},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Animals,Computers,Cryoelectron Microscopy,Cryoelectron Microscopy: instrumentation,Cryoelectron Microscopy: methods,Escherichia coli,Escherichia coli: chemistry,Hemoglobins,Hemoglobins: chemistry,Image Processing, Computer-Assisted,Models, Theoretical,Software},
 pages = {307-69},
 volume = {33},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/11233408},
 month = {11},
 id = {1ea4b56b-251a-34f0-92ba-2542e4d21394},
 created = {2011-07-28T18:39:52.000Z},
 file_attached = {true},
 profile_id = {219e8e76-b8c8-3aa5-898d-2153cb61efd4},
 group_id = {cd79d359-3d3b-38cd-822c-b775fd5f31ce},
 last_modified = {2017-03-14T11:02:08.776Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {VanHeel2000},
 private_publication = {false},
 bibtype = {article},
 author = {van Heel, M and Gowen, B and Matadeen, R and Orlova, E V and Finn, R and Pape, T and Cohen, D and Stark, H and Schmidt, R and Schatz, M and Patwardhan, a},
 journal = {Quarterly reviews of biophysics},
 number = {4}
}

@article{jilani_molecular_1999,
	title = {Molecular cloning of the human gene, {PNKP}, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of {DNA} strand breaks caused by oxidative damage},
	volume = {274},
	issn = {0021-9258},
	abstract = {Mammalian polynucleotide kinases catalyze the 5'-phosphorylation of nucleic acids and can have associated 3'-phosphatase activity, predictive of an important function in DNA repair following ionizing radiation or oxidative damage. The sequences of three tryptic peptides from a bovine 60-kDa polypeptide that correlated with 5'-DNA kinase and 3'-phosphatase activities identified human and murine dbEST clones. The 57.1-kDa conceptual translation product of this gene, polynucleotide kinase 3'-phosphatase (PNKP), contained a putative ATP binding site and a potential 3'-phosphatase domain with similarity to L-2-haloacid dehalogenases. BLAST searches identified possible homologs in Caenorhabditis elegans, Schizosaccharomyces pombe, and Drosophila melanogaster. The gene was localized to chromosome 19q13.3-13.4. Northern analysis indicated a 2-kilobase mRNA in eight human tissues. A glutathione S-transferase-PNKP fusion protein displayed 5'-DNA kinase and 3'-phosphatase activities. PNKP is the first gene for a DNA-specific kinase from any organism. PNKP expression partially rescued the sensitivity to oxidative damaging agents of the Escherichia coli DNA repair-deficient xth nfo double mutant. PNKP gene function restored termini suitable for DNA polymerase, consistent with in vivo removal of 3'-phosphate groups, facilitating DNA repair.},
	language = {eng},
	number = {34},
	journal = {The Journal of Biological Chemistry},
	author = {Jilani, A. and Ramotar, D. and Slack, C. and Ong, C. and Yang, X. M. and Scherer, S. W. and Lasko, D. D.},
	month = aug,
	year = {1999},
	keywords = {Amino Acid Sequence, Animals, Base Sequence, Blotting, Southern, Cattle, Chromosome Mapping, Cloning, Molecular, DNA Damage, DNA Repair, DNA, Complementary, Humans, Hydrogen Peroxide, Molecular Sequence Data, Oxidation-Reduction, Phosphoric Monoester Hydrolases, Polynucleotide 5'-Hydroxyl-Kinase},
	pages = {24176--24186},
}

Paper  abstract   bibtex   

@article{liebana_evaluation_1998,
	title = {Evaluation of the gamma-interferon assay for eradication of tuberculosis in a goat herd},
	volume = {76},
	issn = {0005-0423},
	shorttitle = {Evaluation of the gamma-interferon assay for eradication of tuberculosis in a goat herd},
	url = {://CCC:000071470600021},
	abstract = {Objective To evaluate the usefulness of the gamma-interferon assay in the diagnosis of caprine tuberculosis in comparison with a single intradermal tuberculin test, and to obtain a group of animals free from this infection in a herd with a high prevalence. Design An immunological study involving four serial comparative gamma-interferon and single intradermal tuberculin tests. Animals A herd of 87 goats of Guadarrama breed. Procedure Serial testing and segregation of animals. Results We found that the number of infections detected by the gamma-interferon test was considerably greater than the number detected by the single intradermal tuberculin test. A group of 10 animals was negative to both tests in two consecutive rounds and three kids were negative in the last round of testing. Conclusions Gamma-interferon assay is appropriate for diagnosis and eradication or tuberculosis in goats. This test is able to detect early Mycobacterium bovis infection. Avian reactors with simultaneous increased reaction to bovine PPD in the gamma-interferon assay (designated as avian(B) reactors) should be considered test positive for M bovis. By serial testing with the gamma-interferon and the single intradermal tuberculin tests, and a policy of segregation of kids at birth, it is possible to achieve a group of animals test negative for tuberculosis from a herd of goats with high immunoreactivity to this infection.},
	language = {English},
	number = {1},
	journal = {Australian Veterinary Journal},
	author = {Liebana, E. and Aranaz, A. and Urquia, J. J. and Mateos, A. and Dominguez, L.},
	month = jan,
	year = {1998},
	keywords = {\#nosource, Animals, CATTLE, EPIDEMIOLOGY, MYCOBACTERIUM-BOVIS INFECTION, tuberculosis, goat, Mycobacterium bovis, gamma-interferon, eradication},
	pages = {50--53},
}

@Article{Kitzes1996,
  author   = {LM Kitzes and GS Hollrigel},
  journal  = {Hear Res},
  title    = {Response properties of units in the posterior auditory field deprived of input from the ipsilateral primary auditory cortex.},
  year     = {1996},
  note     = {as cited in \citeNP{Heil1998}},
  number   = {1-2},
  pages    = {120-30},
  volume   = {100},
  abstract = {The influence of the ipsilateral primary auditory field (AI) on the
	response properties of neurons in the posterior auditory field (Field
	P) was examined in three cats anesthetized with sodium pentobarbital.
	Rate/level functions were obtained, by extracellular recording, from
	single units in Field P before (n = 38) and after (n = 50) subpial
	aspiration of AI. The ablations were primarily confined to the medial
	ectosylvian gyrus, although in one case extended into the high-frequency
	portion of the anterior auditory field. Comparisons between the behavior
	of units isolated before and after AI ablation failed to demonstrate
	any changes in the response properties of neurons in Field P attributable
	to the ablation. Nonmonotonic response profiles, first spike latency,
	variability in latency, threshold and maximal discharge rates of
	the units to acoustic stimuli were not significantly altered by the
	AI ablation. These results indicate that the basic response properties
	of neurons in Field P do not depend on input from the ipsilateral
	AI. This suggests that these properties are most likely determined
	by thalamic input or by circuitry within Field P.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, 8922986},
}

@Article{Nakashima_1994_1801,
  author = {Nakashima, Y. and Plump, A. S. and Raines, E. W. and Breslow, J. L. and Ross, R.},
 journal = {Arterioscler.Thromb.},
 note = {DA - 19940204 NOT IN FILE},
 number = {1},
 pages = {133-140},
 title = {Apoe-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree},
 volume = {14},
 year = {1994},
 keywords = {Animals, Aorta, Aorta, Thoracic, Apolipoproteins, E, Arteries, Arteriosclerosis, Atherosclerosis, Carotid, Arteries, Connective, Tissue, Coronary, Vessels, deficiency, Diet, Endothelium, Vascular, etiology, Humans, Hypercholesterolemia, Leukocytes, Mononuclear, Macrophages, Mice, Mice, Inbred, BALB, C, Mice, Inbred, C57BL, Mice, Transgenic, Microscopy, Electron, pathology, Pulmonary, Artery, Research, Support, Non-U.S.Gov't, Research, Support, U.S.Gov't, P.H.S., therapy},
 title_with_no_special_chars = {ApoEdeficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree}
}

Paper  Website  bibtex   

@article{
 title = {Physiological and metabolic responses to hypoxia in invertebrates.},
 type = {article},
 year = {1994},
 identifiers = {[object Object]},
 keywords = {Anaerobiosis,Anaerobiosis: physiology,Animals,Anoxia,Anoxia: metabolism,Anoxia: physiopathology,Energy Metabolism,Energy Metabolism: physiology,Environmental Exposure,Invertebrates,Invertebrates: metabolism,Oxygen,Oxygen: physiology},
 pages = {43-147},
 volume = {125},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/7984874},
 month = {1},
 id = {75b0419c-af14-3ba4-9795-dd12b07b15c3},
 created = {2012-12-06T09:11:04.000Z},
 file_attached = {true},
 profile_id = {0b777e31-8c9d-39dd-97a3-3e054bd99cfe},
 group_id = {764582e8-5773-3a66-8d6b-9b40e4fb5a88},
 last_modified = {2017-03-14T17:27:14.020Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Grieshaber1994},
 bibtype = {article},
 author = {Grieshaber, M K and Hardewig, I and Kreutzer, U and Pörtner, H O},
 journal = {Reviews of physiology, biochemistry and pharmacology}
}

Paper  abstract   bibtex   

@article{lincoln_serum_1990,
	title = {Serum ionized calcium concentration in clinically normal dairy cattle, and changes associated with calcium abnormalities.},
	volume = {197},
	issn = {0003-1488},
	url = {http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&LinkReadableName=Related%20Articles&IdsFromResult=2272878&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum},
	abstract = {Serum ionized calcium (ICa) concentration was determined in 141 clinically normal dairy cattle by use of a direct-measuring calcium ion-selective electrode instrument. Mean serum ICa concentration 2 hours after blood withdrawal was 4.59 mg/dl; range varied from 3.79 to 5.25 mg/dl. Regression analysis indicated a high degree of correlation between ICa and serum total calcium concentrations if serum stored at 23 C was analyzed within 12 hours after blood withdrawal. Abnormal ICa concentration was detected in 19 of 85 dairy cows that were affected with various pathologic conditions. All 19 cows had hypocalcemia (n = 13 with parturient hypocalcemia, 4 with hypomagnesemic tetany, and 2 with renal disease). In all cases, the ICa concentration clearly related to the clinical manifestation of disease and the functional status of the cow's calcium metabolism.},
	number = {11},
	journal = {Journal of the American Veterinary Medical Association},
	author = {Lincoln, S D and Lane, V M},
	month = dec,
	year = {1990},
	keywords = {Animals, Calcium, Cattle, Cattle Diseases, Female, Hydrogen-Ion Concentration, Hypocalcemia, Lactation, Potentiometry, Reference Values, Regression Analysis},
	pages = {1471--4}
}

Paper  doi  abstract   bibtex   

@article{mesulam_large-scale_1990,
	title = {Large-scale neurocognitive networks and distributed processing for attention, language, and memory},
	volume = {28},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2260847},
	doi = {10/fnq75m},
	abstract = {Cognition and comportment are subserved by interconnected neural networks that allow high-level computational architectures including parallel distributed processing. Cognitive problems are not resolved by a sequential and hierarchical progression toward predetermined goals but instead by a simultaneous and interactive consideration of multiple possibilities and constraints until a satisfactory fit is achieved. The resultant texture of mental activity is characterized by almost infinite richness and flexibility. According to this model, complex behavior is mapped at the level of multifocal neural systems rather than specific anatomical sites, giving rise to brain-behavior relationships that are both localized and distributed. Each network contains anatomically addressed channels for transferring information content and chemically addressed pathways for modulating behavioral tone. This approach provides a blueprint for reexploring the neurological foundations of attention, language, memory, and frontal lobe function.},
	number = {5},
	journal = {Annals of Neurology},
	author = {Mesulam, M.M.},
	year = {1990},
	keywords = {\#nosource, Animals, Aphasia/physiopathology, Attention/physiology, Cognition/physiology, Frontal Lobe/physiology, Humans, Learning/physiology, Memory/physiology, Mental Processes/*physiology, Nerve Net/*physiology, Research Support, Non-U.S. Gov't},
	pages = {597--613},
}

Website  bibtex   

@article{
 title = {DNA binding study of isophorone in rats and mice},
 type = {article},
 year = {1990},
 identifiers = {[object Object]},
 keywords = {Animals,Cyclohexanones/*metabolism,DNA/*metabolism,Female,Male,Mice,Rats,Rats, Inbred F344},
 pages = {684-685},
 volume = {64},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2090039},
 edition = {1990/01/01},
 id = {be1a97a7-cc9c-3bef-a0c9-625b8898ee26},
 created = {2017-06-19T13:43:15.318Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:15.427Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Thier, R<m:linebreak/>Peter, H<m:linebreak/>Wiegand, H J<m:linebreak/>Bolt, H M<m:linebreak/>Letter<m:linebreak/>Germany<m:linebreak/>Archives of toxicology<m:linebreak/>Arch Toxicol. 1990;64(8):684-5.</m:note>},
 bibtype = {article},
 author = {Thier, R and Peter, H and Wiegand, H J and Bolt, H M},
 journal = {Arch Toxicol},
 number = {8}
}

@article{bruce_both_1986,
	title = {Both striate cortex and superior colliculus contribute to visual properties of neurons in superior temporal polysensory area of macaque monkey.},
	volume = {55},
	abstract = {Although the tectofugal system projects to the primate cerebral cortex by way of the pulvinar, previous studies have failed to find any physiological evidence that the superior colliculus influences visual activity in the cortex. We studied the relative contributions of the tectofugal and geniculostriate systems to the visual properties of neurons in the superior temporal polysensory area (STP) by comparing the effects of unilateral removal of striate cortex, the superior colliculus, or of both structures. In the intact monkey, STP neurons have large, bilateral receptive fields. Complete unilateral removal of striate cortex did not eliminate visual responses of STP neurons in the contralateral visual hemifield; rather, nearly half the cells still responded to visual stimuli in the hemifield contralateral to the lesion. Thus the visual properties of STP neurons are not completely dependent on the geniculostriate system. Unilateral striate lesions did affect the response properties of STP neurons in three ways. Whereas most STP neurons in the intact monkey respond similarly to stimuli in the two visual hemifields, responses to stimuli in the hemifield contralateral to the striate lesion were usually weaker than responses in the ipsilateral hemifield. Whereas the responses of many STP neurons in the intact monkey were selective for the direction of stimulus motion or for stimulus form, responses in the hemifield contralateral to the striate lesion were not selective for either motion or form. Whereas the median receptive field in the intact monkey extended 80 degrees into the contralateral visual field, the receptive fields of cells with responses in the contralateral field that survived the striate lesions had a median border that extended only 50 degrees into the contralateral visual field. Removal of both striate cortex and the superior colliculus in the same hemisphere abolished the responses of STP neurons to visual stimuli in the hemifield contralateral to the combined lesion. Nearly 80\% of the cells still responded to visual stimuli in the hemifield ipsilateral to the lesion. Unilateral removal of the superior colliculus alone had only small effects on visual responses in STP. Receptive-field size and visual response strength were slightly reduced in the hemifield contralateral to the collicular lesion. As in the intact monkey, selectivity for stimulus motion or form were similar in the two visual hemifields. We conclude that both striate cortex and the superior colliculus contribute to the visual responses of STP neurons. Striate cortex is crucial for the movement and stimulus specificity of neurons in STP.(ABSTRACT TRUNCATED AT 400 WORDS)},
	language = {eng},
	number = {5},
	journal = {J Neurophysiol},
	author = {Bruce, C J and Desimone, R and Gross, C G},
	year = {1986},
	pmid = {3711967},
	note = {Place: UNITED STATES
ISBN: 0022-3077},
	keywords = {Animals, Cerebral Cortex, Evoked Potentials, Visual, Functional Laterality, Macaca fascicularis, Male, Nerve Crush, Neurons, Spatial Behavior, Superior Colliculi, Temporal Lobe, Visual Cortex, Visual Pathways, Visual Perception, research support, u.s. gov't, non-p.h.s., research support, u.s. gov't, p.h.s.},
	pages = {1057--1075},
}

@article{
 title = {Frequency and intensity discrimination in humans and monkeys},
 type = {article},
 year = {1985},
 keywords = {Acoustic Stimulation,Adult,Animals,Auditory Perception/physiology,Cercopithecus aethiops/physiology,Female,Humans,Macaca/physiology,Male,Species Specificity,Speech Acoustics,Speech Perception/physiology,Vestibulocochlear Nerve/physiology},
 pages = {1977-1985},
 volume = {78},
 id = {163a1c5d-06e6-3686-9f07-6e1f76a6fc88},
 created = {2017-09-01T15:54:31.569Z},
 file_attached = {false},
 profile_id = {80da7853-f7b7-36a9-8e4c-d7ddb2d9e538},
 group_id = {a2333ea3-15a4-3d40-8d36-f0d9590ca926},
 last_modified = {2017-09-01T15:54:31.713Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {false},
 hidden = {false},
 language = {eng},
 abstract = {Frequency and intensity DLs were compared in humans and monkeys using a repeating standard "yes-no" procedure in which subjects reported frequency increments, frequency decrements, intensity increments, or intensity decrements in an ongoing train of 1.0-kHz tone bursts. There was only one experimental condition (intensity increments) in which monkey DLs (1.5-2.0 dB) overlapped those of humans (1.0-1.8 dB). For discrimination of both increments and decrements in frequency, monkey DLs (16-33 Hz) were approximately seven times larger than those of humans (2.4-4.8 Hz), and for discrimination of intensity decrements, monkey DLs (4.4-7.0 dB) were very unstable and larger than those of humans (1.0-1.8 dB). For intensity increment discrimination, humans and monkeys also exhibited similar DLs as SL was varied. However, for frequency increment discrimination, best DLs for humans occurred at a high (50 dB) SL, whereas best DLs for monkeys occurred at a moderate (30 dB) SL. Results are discussed in terms of various neural mechanisms that might be differentially engaged by humans and monkeys in performing these tasks; for example, different amounts of temporal versus rate coding in frequency discrimination, and different mechanisms for monitoring rate decreases in intensity discrimination. The implications of these data for using monkeys as models of human speech sound discrimination are also discussed.},
 bibtype = {article},
 author = {Sinnott, J. and Petersen, M. and Hopp, S.},
 number = {6}
}

@Article{Phillips1985,
  author   = {DP Phillips and JR Mendelson and MS Cynader and RM Douglas},
  journal  = {Exp Brain Res},
  title    = {Responses of single neurones in cat auditory cortex to time-varying stimuli: {F}requency-modulated tones of narrow excursion.},
  year     = {1985},
  number   = {3},
  pages    = {443-54},
  volume   = {58},
  abstract = {In the primary auditory cortex of cats anaesthetized with nitrous
	oxide, single neurones were examined with respect to their responses
	to tone bursts and linear modulations of the frequency of an on-going
	continuous tone. Using FM ramps of 2.0 kHz excursion and varying
	centre frequency, each of 39 neurones was examined for its preference
	for the direction of frequency change of a ramp whose centre frequency
	was varied in and around the neurone's response area. Direction preference
	was strictly associated with the slopes of the cell's spike count-versus-frequency
	function over the frequency range covered by the ramp. Preferences
	for upward- and downward-directed ramps were associated with the
	low- and high-frequency slopes of the spike count function, respectively.
	The strength of the cell's direction preference was associated with
	the relative steepness of the spike count function over the frequency
	range covered by the ramp. The timing of discharges elicited by the
	frequency modulations was found to be the sum of the cell's latent
	period for tone bursts plus the time after ramp onset that the stimulus
	frequency fell within the neurone's response area. The implications
	of these data for the processing of narrow and broad frequency-modulated
	ramps are discussed.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, 4007088},
}

@article{anbalagan_influence_1981,
	title = {Influence of an {Indian} medicine ({Ashwagandha}) on acute-phase reactants in inflammation},
	volume = {19},
	issn = {0019-5189},
	language = {eng},
	number = {3},
	journal = {Indian Journal of Experimental Biology},
	author = {Anbalagan, K. and Sadique, J.},
	month = mar,
	year = {1981},
	pmid = {7251069},
	keywords = {Acute Disease, Animals, Anti-Inflammatory Agents, Arthritis, Arthritis, Experimental, Plant Extracts, Plants, Medicinal, Rats, Withania},
	pages = {245--249},
}

Paper  bibtex   

@article{Lezius1967,
	title = {Enzymatic synthesis of {DNA} with 4-thio-thymidine triphosphate as substitute for {dTTP}.},
	volume = {3},
	issn = {0014-2956},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/4295053},
	number = {1},
	journal = {European journal of biochemistry / FEBS},
	author = {Lezius, a G and Scheit, K H},
	month = dec,
	year = {1967},
	pmid = {4295053},
	keywords = {\#nosource, Animals, Carbon Isotopes, Catalysis, Cattle, Cellulose, Centrifugation, Chromatography, DNA, DNA Nucleotidyltransferases, Density Gradient, Deoxyribonucleases, Escherichia coli, Escherichia coli: enzymology, Genetic, Glass, Nucleotides, Pancreas, Pancreas: enzymology, Paper, Phosphoric Monoester Hydrolases, Phosphorus Isotopes, Polymers, Snakes, Spectrophotometry, Sulfhydryl Compounds, Templates, Thymidine, Thymus Gland, Thymus Gland: enzymology, Tritium, Venoms},
	pages = {85--94},
}

@article{della_fera_persistent_2021,
	title = {Persistent Human Papillomavirus Infection},
	volume = {13},
	issn = {1999-4915},
	doi = {10.3390/v13020321},
	abstract = {Persistent infection with oncogenic human papillomavirus ({HPV}) types is responsible for {\textasciitilde}5\% of human cancers. The {HPV} infectious cycle can sustain long-term infection in stratified epithelia because viral {DNA} is maintained as low copy number extrachromosomal plasmids in the dividing basal cells of a lesion, while progeny viral genomes are amplified to large numbers in differentiated superficial cells. The viral E1 and E2 proteins initiate viral {DNA} replication and maintain and partition viral genomes, in concert with the cellular replication machinery. Additionally, the E5, E6, and E7 proteins are required to evade host immune responses and to produce a cellular environment that supports viral {DNA} replication. An unfortunate consequence of the manipulation of cellular proliferation and differentiation is that cells become at high risk for carcinogenesis.},
	pages = {321},
	number = {2},
	journaltitle = {Viruses},
	shortjournal = {Viruses},
	author = {Della Fera, Ashley N. and Warburton, Alix and Coursey, Tami L. and Khurana, Simran and {McBride}, Alison A.},
	date = {2021-02-20},
	pmid = {33672465},
	pmcid = {PMC7923415},
	keywords = {cancer, papillomavirus, {HPV}, Humans, Papillomavirus Infections, Virus Replication, latency, Papillomaviridae, persistence, {DNA}, Viral, Animals, epithelium, extrachromosomal replication, Genome, Viral, immune evasion, tethering},
	file = {Plný text:C\:\\Users\\Miroslava Kuderavá\\Zotero\\storage\\PG4QMPJY\\Della Fera et al. - 2021 - Persistent Human Papillomavirus Infection.pdf:application/pdf},
}