The effect of context and audio-visual modality on emotions elicited by a musical performance. Coutinho, E. & Scherer, K., R. Psychology of Music, 45(4):550-569, 7, 2017. Website doi abstract bibtex 1 download In this work, we compared emotions induced by the same performance of Schubert Lieder during a live concert and in a laboratory viewing/listening setting to determine the extent to which laboratory research on affective reactions to music approximates real listening conditions in dedicated performances. We measured emotions experienced by volunteer members of an audience that attended a Lieder recital in a church (Context 1) and emotional reactions to an audio-video-recording of the same performance in a university lecture hall (Context 2). Three groups of participants were exposed to three presentation versions in Context 2: (1) an audio-visual recording, (2) an audio-only recording, and (3) a video-only recording. Participants achieved statistically higher levels of emotional convergence in the live performance than in the laboratory context, and the experience of particular emotions was determined by complex interactions between auditory and visual cues in the performance. This study demonstrates the contribution of the performance setting and the performers' appearance and nonverbal expression to emotion induction by music, encouraging further systematic research into the factors involved.
@article{
title = {The effect of context and audio-visual modality on emotions elicited by a musical performance},
type = {article},
year = {2017},
keywords = {article,journal},
pages = {550-569},
volume = {45},
websites = {http://dx.doi.org/10.1177/0305735616670496 http://journals.sagepub.com/doi/10.1177/0305735616670496,http://dx.doi.org/10.1177/0305735616670496,http://journals.sagepub.com/doi/10.1177/0305735616670496},
month = {7},
day = {26},
id = {afc391cf-b15a-3422-b5d4-fa0c6522d298},
created = {2020-05-29T11:51:37.246Z},
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profile_id = {ffa9027c-806a-3827-93a1-02c42eb146a1},
last_modified = {2023-05-15T08:14:21.220Z},
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private_publication = {false},
abstract = {In this work, we compared emotions induced by the same performance of Schubert Lieder during a live concert and in a laboratory viewing/listening setting to determine the extent to which laboratory research on affective reactions to music approximates real listening conditions in dedicated performances. We measured emotions experienced by volunteer members of an audience that attended a Lieder recital in a church (Context 1) and emotional reactions to an audio-video-recording of the same performance in a university lecture hall (Context 2). Three groups of participants were exposed to three presentation versions in Context 2: (1) an audio-visual recording, (2) an audio-only recording, and (3) a video-only recording. Participants achieved statistically higher levels of emotional convergence in the live performance than in the laboratory context, and the experience of particular emotions was determined by complex interactions between auditory and visual cues in the performance. This study demonstrates the contribution of the performance setting and the performers' appearance and nonverbal expression to emotion induction by music, encouraging further systematic research into the factors involved.},
bibtype = {article},
author = {Coutinho, Eduardo and Scherer, Klaus R.},
doi = {10.1177/0305735616670496},
journal = {Psychology of Music},
number = {4}
}
Morphine Use in the ED and Outcomes of Patients With Acute Heart Failure: A Propensity Score-Matching Analysis Based on the EAHFE Registry. Miró, Ò., Gil, V., Martín-Sánchez, F. J., Herrero-Puente, P., Jacob, J., Mebazaa, A., Harjola, V., Ríos, J., Hollander, J. E., Peacock, W. F., & Llorens, P. Chest, 152(4):821–832, 2017. Paper doi abstract bibtex The objective was to determine the relationship between short-term mortality and intravenous morphine use in ED patients who received a diagnosis of acute heart failure (AHF). Consecutive patients with AHF presenting to 34 Spanish EDs from 2011 to 2014 were eligible for inclusion. The subjects were divided into those with (M) or without IV morphine treatment (WOM) groups during ED stay. The primary outcome was 30-day all-cause mortality, and secondary outcomes were mortality at different intermediate time points, in-hospital mortality, and length of hospital stay. We generated a propensity score to match the M and WOM groups that were 1:1 according to 46 different epidemiological, baseline, clinical, and therapeutic factors. We investigated independent risk factors for 30-day mortality in patients receiving morphine. We included 6,516 patients (mean age, 81 [SD, 10] years; 56% women): 416 (6.4%) in the M and 6,100 (93.6%) in the WOM group. Overall, 635 (9.7%; M, 26.7%; WOM, 8.6%) died by day 30. After propensity score matching, 275 paired patients constituted each group. Patients receiving morphine had a higher 30-day mortality (55 [20.0%] vs 35 [12.7%] deaths; hazard ratio, 1.66; 95% CI, 1.09-2.54; P = .017). In patients receiving morphine, death was directly related to glycemia (P = .013) and inversely related to the baseline Barthel index and systolic BP (P = .021) at ED arrival (P = .021). Mortality was increased at every intermediate time point, although the greatest risk was at the shortest time (at 3 days: 22 [8.0%] vs 7 [2.5%] deaths; OR, 3.33; 95% CI, 1.40-7.93; P = .014). In-hospital mortality did not increase (39 [14.2%] vs 26 [9.1%] deaths; OR, 1.65; 95% CI, 0.97-2.82; P = .083) and LOS did not differ between groups (median [interquartile range] in M, 8 [7]; WOM, 8 [6]; P = .79). This propensity score-matched analysis suggests that the use of IV morphine in AHF could be associated with increased 30-day mortality.
@article{miro_morphine_2017,
title = {Morphine {Use} in the {ED} and {Outcomes} of {Patients} {With} {Acute} {Heart} {Failure}: {A} {Propensity} {Score}-{Matching} {Analysis} {Based} on the {EAHFE} {Registry}},
volume = {152},
issn = {0012-3692},
shorttitle = {Morphine {Use} in the {ED} and {Outcomes} of {Patients} {With} {Acute} {Heart} {Failure}},
url = {http://www.sciencedirect.com/science/article/pii/S0012369217307079},
doi = {10.1016/j.chest.2017.03.037},
abstract = {The objective was to determine the relationship between short-term mortality and intravenous morphine use in ED patients who received a diagnosis of acute heart failure (AHF). Consecutive patients with AHF presenting to 34 Spanish EDs from 2011 to 2014 were eligible for inclusion. The subjects were divided into those with (M) or without IV morphine treatment (WOM) groups during ED stay. The primary outcome was 30-day all-cause mortality, and secondary outcomes were mortality at different intermediate time points, in-hospital mortality, and length of hospital stay. We generated a propensity score to match the M and WOM groups that were 1:1 according to 46 different epidemiological, baseline, clinical, and therapeutic factors. We investigated independent risk factors for 30-day mortality in patients receiving morphine. We included 6,516 patients (mean age, 81 [SD, 10] years; 56\% women): 416 (6.4\%) in the M and 6,100 (93.6\%) in the WOM group. Overall, 635 (9.7\%; M, 26.7\%; WOM, 8.6\%) died by day 30. After propensity score matching, 275 paired patients constituted each group. Patients receiving morphine had a higher 30-day mortality (55 [20.0\%] vs 35 [12.7\%] deaths; hazard ratio, 1.66; 95\% CI, 1.09-2.54; P = .017). In patients receiving morphine, death was directly related to glycemia (P = .013) and inversely related to the baseline Barthel index and systolic BP (P = .021) at ED arrival (P = .021). Mortality was increased at every intermediate time point, although the greatest risk was at the shortest time (at 3 days: 22 [8.0\%] vs 7 [2.5\%] deaths; OR, 3.33; 95\% CI, 1.40-7.93; P = .014). In-hospital mortality did not increase (39 [14.2\%] vs 26 [9.1\%] deaths; OR, 1.65; 95\% CI, 0.97-2.82; P = .083) and LOS did not differ between groups (median [interquartile range] in M, 8 [7]; WOM, 8 [6]; P = .79). This propensity score-matched analysis suggests that the use of IV morphine in AHF could be associated with increased 30-day mortality.},
number = {4},
urldate = {2018-01-16},
journal = {Chest},
author = {Miró, Òscar and Gil, Víctor and Martín-Sánchez, Francisco J. and Herrero-Puente, Pablo and Jacob, Javier and Mebazaa, Alexandre and Harjola, Veli-Pekka and Ríos, José and Hollander, Judd E. and Peacock, W. Frank and Llorens, Pere},
year = {2017},
keywords = {Article, ED, Urgències, acute heart failure, morphine, opiates, outcome},
pages = {821--832},
}
Teduglutide: A Review in Short Bowel Syndrome. Kim E.S. & Keam S.J. 2017. Paper abstract bibtex Subcutaneous teduglutide (Revestive), a glucagon-like peptide-2 analogue that increases intestinal absorption, is approved in the EU for the treatment of short bowel syndrome (SBS) in patients aged \textgreater1 year who are stable following a period of postsurgical intestinal adaptation. In a phase III trial in adults with SBS intestinal failure (IF) dependent on parenteral support (PS), a significantly greater proportion of teduglutide 0.05 mg/kg/day than placebo recipients achieved a \textgreater20% reduction in weekly PS volume from baseline to week 20 and maintained it to week 24. The proportion of patients who had a reduction in one or more days on PS was also significant with teduglutide compared with placebo. Improved intestinal absorption and reduced PS requirements were generally maintained in the longer term. Results from a phase III trial in paediatric patients with SBS-IF dependent on PS were consistent with those in adults. Adverse events were mostly of mild to moderate severity and generally consistent with the underlying condition or known mechanism of the drug (e.g. central line-related issues, gastrointestinal events). Teduglutide is therefore a useful treatment option in children (aged \textgreater1 year), adolescents and adults with SBS. Copyright © 2017, Springer International Publishing Switzerland. All Right Reserved.
@misc{kim_e.s._teduglutide:_2017,
title = {Teduglutide: {A} {Review} in {Short} {Bowel} {Syndrome}},
url = {http://rd.springer.com/journal/40265},
abstract = {Subcutaneous teduglutide (Revestive), a glucagon-like peptide-2 analogue that increases intestinal absorption, is approved in the EU for the treatment of short bowel syndrome (SBS) in patients aged {\textgreater}1 year who are stable following a period of postsurgical intestinal adaptation. In a phase III trial in adults with SBS intestinal failure (IF) dependent on parenteral support (PS), a significantly greater proportion of teduglutide 0.05 mg/kg/day than placebo recipients achieved a {\textgreater}20\% reduction in weekly PS volume from baseline to week 20 and maintained it to week 24. The proportion of patients who had a reduction in one or more days on PS was also significant with teduglutide compared with placebo. Improved intestinal absorption and reduced PS requirements were generally maintained in the longer term. Results from a phase III trial in paediatric patients with SBS-IF dependent on PS were consistent with those in adults. Adverse events were mostly of mild to moderate severity and generally consistent with the underlying condition or known mechanism of the drug (e.g. central line-related issues, gastrointestinal events). Teduglutide is therefore a useful treatment option in children (aged {\textgreater}1 year), adolescents and adults with SBS. Copyright © 2017, Springer International Publishing Switzerland. All Right Reserved.},
journal = {Drugs},
author = {{Kim E.S.} and {Keam S.J.}},
year = {2017},
keywords = {*short bowel syndrome, *short bowel syndrome/dt [Drug Therapy], *short bowel syndrome/th [Therapy], *teduglutide, *teduglutide/ae [Adverse Drug Reaction], *teduglutide/dt [Drug Therapy], *teduglutide/pd [Pharmacology], *teduglutide/pk [Pharmacokinetics], *teduglutide/sc [Subcutaneous Drug Administration], Child, Parenteral nutrition, abdominal distension/si [Side Effect], acute cholecystitis/si [Side Effect], adolescent, adult, adverse drug reaction, article, catheter infection/co [Complication], central venous catheter, central venous catheter/am [Adverse Device Effect], clinical study, clinical trial, controlled clinical trial, controlled study, decreased appetite/si [Side Effect], disease severity, drug efficacy, drug therapy, drug tolerability, gastrointestinal dysplasia/si [Side Effect], gastrointestinal polyposis/si [Side Effect], gastrointestinal symptom/si [Side Effect], gastrointestinal tract, gastrointestinal tumor/si [Side Effect], human, infant, influenza/si [Side Effect], injection site erythema/si [Side Effect], intestinal failure, intestine absorption, intestine polyp/si [Side Effect], intestine stenosis/si [Side Effect], multicenter study (topic), nonhuman, peripheral edema/si [Side Effect], pharmacodynamic parameters, phase 3 clinical trial, phase 3 clinical trial (topic), placebo, recipient, rectum polyp/si [Side Effect], rhinopharyngitis/si [Side Effect], sepsis/co [Complication], short bowel syndrome/dt [Drug Therapy], side effect, stomach adenoma/si [Side Effect], systematic review, upper abdominal pain/si [Side Effect]}
}
Radiocephalic Arteriovenous Fistulae As First Vascular Access In Elderly Patients In Hemodialysis. Tapia González I, Martinez Carnovale L, Esteve Simó V, De la Torre Moran A, & Ramírez de Arellano Serna M Journal of Vascular Access, 18:S46–S47, 2017. Paper abstract bibtex Abstract unavailable for this article.
@article{tapia_gonzalez_i_radiocephalic_2017-1,
title = {Radiocephalic {Arteriovenous} {Fistulae} {As} {First} {Vascular} {Access} {In} {Elderly} {Patients} {In} {Hemodialysis}},
volume = {18},
issn = {1724-6032},
shorttitle = {\textbf{radiocephalic {Arteriovenous} {Fistulae} {As} {First} {Vascular} {Access} {In} {Elderly} {Patients} {In} {Hemodialysis}}},
url = {https://insights.ovid.com/vascular-access/tjova/2017/04/002/radiocephalic-arteriovenous-fistulae-first/113/01199686},
abstract = {Abstract unavailable for this article.},
language = {ENGLISH},
urldate = {2018-01-16},
journal = {Journal of Vascular Access},
author = {{Tapia González I} and {Martinez Carnovale L} and {Esteve Simó V} and {De la Torre Moran A} and {Ramírez de Arellano Serna M}},
year = {2017},
pmid = {01199686-201704002-00113},
keywords = {Article, Nefrologia},
pages = {S46--S47},
}
Abiotic processes are insufficient for fertile island development: A 10-year artificial shrub experiment in a desert grassland. Li, J., Gilhooly III, W. P., Okin, G. S., & Blackwell III, J. Geophysical Research Letters, doi: 10.1002/2016GL072068:9 pgs, 2017. abstract bibtex The relative importance of biotic and abiotic processes in the development of �fertile islands� in dryland systems has rarely been investigated. Here we approached this question by using artificial shrubs, which exclude plant litter production and soil nutrient uptake, but retain the functions of trapping windblown material, funneling of stemflow, and differential rain splash. We conducted a vegetation manipulation study more than a decade ago in the desert grassland of southern New Mexico and subsequently revisited the site in 2012 and 2015. The results show that no notable soil mounds were observed under the artificial shrubs; however, soil texture under the artificial shrubs has gradually changed to resemble the patterns of soil particle-size distribution under natural shrubs. Our results highlight that with the exclusion of direct biotic additions, soils captured by shrub canopies are not necessarily fertile and thus do not themselves contribute to the development of fertile islands.
@article{li_abiotic_2017,
title = {Abiotic processes are insufficient for fertile island development: {A} 10-year artificial shrub experiment in a desert grassland},
volume = {doi: 10.1002/2016GL072068},
abstract = {The relative importance of biotic and abiotic processes in the development of �fertile islands� in dryland systems has rarely been investigated. Here we approached this question by using artificial shrubs, which exclude plant litter production and soil nutrient uptake, but retain the functions of trapping windblown material, funneling of stemflow, and differential rain splash. We conducted a vegetation manipulation study more than a decade ago in the desert grassland of southern New Mexico and subsequently revisited the site in 2012 and 2015. The results show that no notable soil mounds were observed under the artificial shrubs; however, soil texture under the artificial shrubs has gradually changed to resemble the patterns of soil particle-size distribution under natural shrubs. Our results highlight that with the exclusion of direct biotic additions, soils captured by shrub canopies are not necessarily fertile and thus do not themselves contribute to the development of fertile islands.},
journal = {Geophysical Research Letters},
author = {Li, Junran and Gilhooly III, William P. and Okin, Gregory S. and Blackwell III, John},
year = {2017},
keywords = {LTER, abiotic processes, aeolian process, article, artificial shrubs, biotic process, desert grassland, fertile islands, journal},
pages = {9 pgs}
}
Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: A randomized trial. Totonchi Z., Rezvani H., Ghorbanloo M., Yazdanian F., Mahdavi M., Babaali N., Salajegheh S., & Chitsazan M. 2017. Paper abstract bibtex Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.
@misc{totonchi_z._effect_2017,
title = {Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: {A} randomized trial},
url = {http://cardiovascmed.com/72535.pdf},
abstract = {Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.},
journal = {Research in Cardiovascular Medicine},
author = {{Totonchi Z.} and {Rezvani H.} and {Ghorbanloo M.} and {Yazdanian F.} and {Mahdavi M.} and {Babaali N.} and {Salajegheh S.} and {Chitsazan M.}},
year = {2017},
keywords = {*chemical stress, *dexmedetomidine, *dexmedetomidine/ct [Clinical Trial], *diastolic blood pressure, *heart surgery, *hemodynamics, *infusion, *open heart surgery, *stress, Anesthesia, C reactive protein, C reactive protein/ec [Endogenous Compound], Child, adjuvant, artery catheter, article, cardiopulmonary bypass, central venous catheter, central venous pressure, clinical article, clinical trial, continuous infusion, control group, controlled clinical trial, controlled study, diastolic blood pressure, drug therapy, endogenous compound, female, fentanyl, heart rate, human, hypertension, hypotension, incidence, infant, inflammation, intensive care unit, interleukin 6, interleukin 6/ec [Endogenous Compound], lactate dehydrogenase/ec [Endogenous Compound], lactic acid, loading drug dose, lymphotoxin beta, maintenance drug dose, male, midazolam, normal human, preschool child, prospective study, randomized controlled trial, sampling, single blind procedure, skin incision, sodium chloride, sternotomy, systolic blood pressure, tumor necrosis factor/ec [Endogenous Compound]}
}
Morbidity and mortality of very low birth weight multiples compared with singletons. Porta, R., Capdevila, E., Botet, F., Verd, S., Ginovart, G., Moliner, E., Nicolàs, M., Rios, J., & SEN1500 Network Journal of Maternal-Fetal & Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2017. doi abstract bibtex BACKGROUND: Previous studies comparing the neonatal outcome of very low birth weight (VLBW) multiples and singletons have suggested a worse outcome for multiples at gestational ages on the limits of viability. OBJECTIVES: The objective of this study is to determine the neonatal mortality and morbidity of VLBW multiples compared to singletons. METHODS: This is a retrospective study including all infants registered in the Spanish network for infants under 1500 g (SEN1500), over a 12-year period (from 2002 to 2013). Mortality and major morbidities were compared between singletons and multiples. RESULTS: About 32,770 infants were included: 21,123 singletons (64.5%) and 11,647 multiples (35.5%), with a mean gestational age of 29.5 weeks (22-38), and mean birth weight of 1115 g (340-1500). When adjusted by other perinatal factors, multiple pregnancy has a significantly higher risk of mortality than singleton pregnancy (odds ratio (OR) 1.15; IC 95% 1.05-1.26, p = .002), but not a higher risk of major morbidity or composite adverse outcome. In the subgroup of infants born before 26 weeks, multiples showed a higher risk of mortality (63.9% versus 51%, OR 1.7; 95% CI 1.47-1.96) and a higher risk of composite adverse outcome (88.9% versus 81.5%, OR 1.82, 95% CI 1.28-2.24). CONCLUSIONS: In preterm infants born with less than 1500 g, multiple pregnancy is a prognostic factor that can slightly increase mortality. Extremely preterm infants born before 26 weeks have a greater risk of mortality and major morbidity if they come from a multiple pregnancy.
@article{porta_morbidity_2017,
title = {Morbidity and mortality of very low birth weight multiples compared with singletons},
issn = {1476-4954},
doi = {10.1080/14767058.2017.1379073},
abstract = {BACKGROUND: Previous studies comparing the neonatal outcome of very low birth weight (VLBW) multiples and singletons have suggested a worse outcome for multiples at gestational ages on the limits of viability.
OBJECTIVES: The objective of this study is to determine the neonatal mortality and morbidity of VLBW multiples compared to singletons.
METHODS: This is a retrospective study including all infants registered in the Spanish network for infants under 1500 g (SEN1500), over a 12-year period (from 2002 to 2013). Mortality and major morbidities were compared between singletons and multiples.
RESULTS: About 32,770 infants were included: 21,123 singletons (64.5\%) and 11,647 multiples (35.5\%), with a mean gestational age of 29.5 weeks (22-38), and mean birth weight of 1115 g (340-1500). When adjusted by other perinatal factors, multiple pregnancy has a significantly higher risk of mortality than singleton pregnancy (odds ratio (OR) 1.15; IC 95\% 1.05-1.26, p = .002), but not a higher risk of major morbidity or composite adverse outcome. In the subgroup of infants born before 26 weeks, multiples showed a higher risk of mortality (63.9\% versus 51\%, OR 1.7; 95\% CI 1.47-1.96) and a higher risk of composite adverse outcome (88.9\% versus 81.5\%, OR 1.82, 95\% CI 1.28-2.24).
CONCLUSIONS: In preterm infants born with less than 1500 g, multiple pregnancy is a prognostic factor that can slightly increase mortality. Extremely preterm infants born before 26 weeks have a greater risk of mortality and major morbidity if they come from a multiple pregnancy.},
language = {eng},
journal = {Journal of Maternal-Fetal \& Neonatal Medicine: The Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
author = {Porta, Roser and Capdevila, Eva and Botet, Francesc and Verd, Sergi and Ginovart, Gemma and Moliner, Elisenda and Nicolàs, Marta and Rios, Jose and {SEN1500 Network}},
year = {2017},
pmid = {28936899},
keywords = {Article, Mortality, Pediatria, multiples, singletons},
pages = {1--9},
}
The effects of tracheal tube cuffs filled with air, saline or alkalinised lidocaine on haemodynamic changes and laryngotracheal morbidity in children: a randomised, controlled trial. Soares S.M.F., Arantes V.M., Modolo M.P., dos Santos V.J.B., Vane L.A., Navarro e Lima L.H., Braz L.G., do Nascimento P., & Modolo N.S.P. 2017. Paper abstract bibtex We studied the effects of tracheal tube cuffs filled with air, saline or alkalinised lidocaine on haemodynamic changes during tracheal extubation and postoperative laryngotracheal morbidity in children. We randomly allocated 164 children aged 3-13 years undergoing general anaesthesia to one of four groups; tracheal tube cuffs filled with air (n = 41); saline (n = 41); alkalinised lidocaine 0.5% (n = 41); or alkalinised lidocaine 1% (n = 41). Intracuff pressure was monitored and maintained below 20 cmH2O. The mean (SD) increases in systolic blood pressure after tracheal extubation compared with before extubation were 10.9 (10.8) mmHg, 7.3 (17.7) mmHg, 4.1 (10.5) mmHg and 1.9 (9.5) mmHg in the air, saline, 0.5% and 1% alkalinised lidocaine groups, respectively (p = 0.021). The mean (SD) increases in diastolic blood pressure after tracheal extubation compared with before extubation were 3.9 (9.7) mmHg, 7.9 (14.6) mmHg, 0.7 (10.4) mmHg and 3.6 (6.9) mmHg in the air, saline, 0.5% and 1% alkalinised lidocaine groups, respectively (p = 0.019). The mean (SD) increases in heart rate after tracheal extubation compared with before extubation were 14.2 (7.6) beats.min-1, 15.5 (13.1) beats.min-1, 5.2 (9.6) beats.min-1 and 4.1 (6.6) beats.min-1 in the air, saline, 0.5% and 1% alkalinised lidocaine groups, respectively (p \textless 0.001). The incidence of sore throat 8 h after tracheal extubation was 22.0% in the air-filled group, 9.8% in the saline group, 4.9% in the 0.5% alkalinised lidocaine group and 2.4% in the 1% alkalinised lidocaine group, p = 0.015. We conclude that filling the tracheal tube cuff with alkalinised lidocaine-filled reduces the haemodynamic response to tracheal extubation and postoperative laryngotracheal morbidity in children. Copyright © 2016 The Association of Anaesthetists of Great Britain and Ireland
@misc{soares_s.m.f._effects_2017,
title = {The effects of tracheal tube cuffs filled with air, saline or alkalinised lidocaine on haemodynamic changes and laryngotracheal morbidity in children: a randomised, controlled trial},
url = {http://www.interscience.wiley.com/jpages/0003-2409},
abstract = {We studied the effects of tracheal tube cuffs filled with air, saline or alkalinised lidocaine on haemodynamic changes during tracheal extubation and postoperative laryngotracheal morbidity in children. We randomly allocated 164 children aged 3-13 years undergoing general anaesthesia to one of four groups; tracheal tube cuffs filled with air (n = 41); saline (n = 41); alkalinised lidocaine 0.5\% (n = 41); or alkalinised lidocaine 1\% (n = 41). Intracuff pressure was monitored and maintained below 20 cmH2O. The mean (SD) increases in systolic blood pressure after tracheal extubation compared with before extubation were 10.9 (10.8) mmHg, 7.3 (17.7) mmHg, 4.1 (10.5) mmHg and 1.9 (9.5) mmHg in the air, saline, 0.5\% and 1\% alkalinised lidocaine groups, respectively (p = 0.021). The mean (SD) increases in diastolic blood pressure after tracheal extubation compared with before extubation were 3.9 (9.7) mmHg, 7.9 (14.6) mmHg, 0.7 (10.4) mmHg and 3.6 (6.9) mmHg in the air, saline, 0.5\% and 1\% alkalinised lidocaine groups, respectively (p = 0.019). The mean (SD) increases in heart rate after tracheal extubation compared with before extubation were 14.2 (7.6) beats.min-1, 15.5 (13.1) beats.min-1, 5.2 (9.6) beats.min-1 and 4.1 (6.6) beats.min-1 in the air, saline, 0.5\% and 1\% alkalinised lidocaine groups, respectively (p {\textless} 0.001). The incidence of sore throat 8 h after tracheal extubation was 22.0\% in the air-filled group, 9.8\% in the saline group, 4.9\% in the 0.5\% alkalinised lidocaine group and 2.4\% in the 1\% alkalinised lidocaine group, p = 0.015. We conclude that filling the tracheal tube cuff with alkalinised lidocaine-filled reduces the haemodynamic response to tracheal extubation and postoperative laryngotracheal morbidity in children. Copyright © 2016 The Association of Anaesthetists of Great Britain and Ireland},
journal = {Anaesthesia},
author = {{Soares S.M.F.} and {Arantes V.M.} and {Modolo M.P.} and {dos Santos V.J.B.} and {Vane L.A.} and {Navarro e Lima L.H.} and {Braz L.G.} and {do Nascimento P.} and {Modolo N.S.P.}},
year = {2017},
keywords = {*air, *childhood mortality, *diastolic blood pressure, *endotracheal tube, *endotracheal tube cuff, *lidocaine, *lung hemodynamics, *morbidity, *pediatrics, *pneumatic cuff, *respiration control, *sodium chloride, *sore throat, Child, adolescent, alfentanil, anesthesia induction, article, atropine, controlled clinical trial, controlled study, diastolic blood pressure, dipyrone, extubation, female, fentanyl, general anesthesia, heart rate, human, major clinical study, male, neostigmine, ondansetron, postoperative analgesia, preschool child, pressure measurement, propofol, randomized controlled trial, rocuronium, sevoflurane, sore throat/co [Complication], surgery, systolic blood pressure, tramadol}
}
The effect of prior tetanic stimulation on train-of-four monitoring in paediatric patients. Carlos R.V., De Boer H.D., Torres M.L.A., & Carmona M.J.C. 2017. Paper abstract bibtex Background In clinical research, neuromuscular monitoring must present a stable response for a period of 2 to 5 min before administration of a neuromuscular blocking agent. The time required to reach this stable response may be shortened by applying a 5-s tetanic stimulus. OBJECTIVES The aim of this study was to test whether tetanic stimulation interferes with onset and recovery times after a single dose of rocuronium 0.6 mg kg+/-1 followed by spontaneous recovery. DESIGN A randomised, open-label, controlled trial. SETTING A single-centre trial, study period from January 2014 to July 2015. PATIENTS Fifty children aged 2 to 11 years scheduled for elective paediatric surgery. INTERVENTION Patients were randomly allocated to receive either tetanic stimulation (group T) or not (group C) before calibration of the neuromuscular monitor. MAIN OUTCOME MEASURES Onset and recovery times. Initial and final T1 height, time to obtain initial T1 height stability and monitor settings were also analysed. RESULTS There was no significant difference in mean onset time [(C: 57.5 (+/- 16.9) vs. T: 58.3 (+/- 31.2) s; P = 0.917]. Mean times to normalised train-of-four (TOF) ratios of 0.7, 0.8 and 0.9 were significantly shorter in the tetanic stimulation group [C: 40.1 (+/-7.9) vs. T: 34.8 (+/-10) min; P = 0.047, C: 43.8 (+/-9.4) vs. T: 37.4 (+/-11) min; P = 0.045 and C: 49.9 (+/-12.2) vs. T: 41.7 (+/-13.1) min; P = 0.026, respectively]. The mean time required for T1 height stabilisation was similar in the two groups [C: 195.0 (+/- 203.0) vs. T: 116.0 (+/- 81.6) s; P = 0.093], but the initial and final T1 height values were significantly lower in the tetanic stimulation group (C: 98.0 vs. T: 82.7%; P \textless 0.001 and C: 95.3 vs. T: 69.3%; P \textless 0.001, respectively). CONCLUSION Tetanic stimulation shortened the mean times to normalised TOF ratios of 0.7, 0.8 and 0.9, but there was no difference in the mean onset time or the mean time required for T1 height stabilisation after a single dose of rocuronium 0.6 mg kg+/-1 followed by spontaneous recovery in children aged 2 to 11 years. Copyright © 2017 European Society of Anaesthesiology. All rights reserved.
@misc{carlos_r.v._effect_2017,
title = {The effect of prior tetanic stimulation on train-of-four monitoring in paediatric patients},
url = {http://journals.lww.com/ejanaesthesiology/pages/default.aspx},
abstract = {Background In clinical research, neuromuscular monitoring must present a stable response for a period of 2 to 5 min before administration of a neuromuscular blocking agent. The time required to reach this stable response may be shortened by applying a 5-s tetanic stimulus. OBJECTIVES The aim of this study was to test whether tetanic stimulation interferes with onset and recovery times after a single dose of rocuronium 0.6 mg kg+/-1 followed by spontaneous recovery. DESIGN A randomised, open-label, controlled trial. SETTING A single-centre trial, study period from January 2014 to July 2015. PATIENTS Fifty children aged 2 to 11 years scheduled for elective paediatric surgery. INTERVENTION Patients were randomly allocated to receive either tetanic stimulation (group T) or not (group C) before calibration of the neuromuscular monitor. MAIN OUTCOME MEASURES Onset and recovery times. Initial and final T1 height, time to obtain initial T1 height stability and monitor settings were also analysed. RESULTS There was no significant difference in mean onset time [(C: 57.5 (+/- 16.9) vs. T: 58.3 (+/- 31.2) s; P = 0.917]. Mean times to normalised train-of-four (TOF) ratios of 0.7, 0.8 and 0.9 were significantly shorter in the tetanic stimulation group [C: 40.1 (+/-7.9) vs. T: 34.8 (+/-10) min; P = 0.047, C: 43.8 (+/-9.4) vs. T: 37.4 (+/-11) min; P = 0.045 and C: 49.9 (+/-12.2) vs. T: 41.7 (+/-13.1) min; P = 0.026, respectively]. The mean time required for T1 height stabilisation was similar in the two groups [C: 195.0 (+/- 203.0) vs. T: 116.0 (+/- 81.6) s; P = 0.093], but the initial and final T1 height values were significantly lower in the tetanic stimulation group (C: 98.0 vs. T: 82.7\%; P {\textless} 0.001 and C: 95.3 vs. T: 69.3\%; P {\textless} 0.001, respectively). CONCLUSION Tetanic stimulation shortened the mean times to normalised TOF ratios of 0.7, 0.8 and 0.9, but there was no difference in the mean onset time or the mean time required for T1 height stabilisation after a single dose of rocuronium 0.6 mg kg+/-1 followed by spontaneous recovery in children aged 2 to 11 years. Copyright © 2017 European Society of Anaesthesiology. All rights reserved.},
journal = {European Journal of Anaesthesiology},
author = {{Carlos R.V.} and {De Boer H.D.} and {Torres M.L.A.} and {Carmona M.J.C.}},
year = {2017},
keywords = {*monitoring, *muscle excitation, *neuromuscular monitoring, *stimulus response, *tetanic stimulation, *train of four monitoring, Child, anesthetic recovery, article, calibration, clinical article, controlled clinical trial, controlled study, elective surgery, electric peripheral nerve stimulator, female, gas analysis equipment, height, human, male, open study, parameters, patient monitoring, pediatric surgery, randomized controlled trial, remission, rocuronium, single drug dose, thermal regulating system}
}
Universal versus conditional three-day follow up visit for children with uncomplicated fever at the community level: Design of a cluster-randomized, community-based, non-inferiority trial in Tanganyika, Democratic Republic of Congo. van Boetzelaer E., Ho L.S., Gutman J.R., Steinhardt L.C., Wittcoff A., Barbera Y., Ngoy P., Harvey S.A., & Mullany L.C. 2017. Paper abstract bibtex Background: The current recommendation within integrated Community Case Management guidelines that all children presenting with uncomplicated fever and no danger signs be followed up after three days may not be necessary. Such fevers often resolve rapidly (usually within 48-96 h), and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aim to determine the non-inferiority of a conditional versus a universal follow-up visit for these children. Methods: We are conducting a cluster-randomized, community-based, non-inferiority trial enrolling \textasciitilde4300 children (ages 2-59 months) presenting to community health workers (CHWs) with uncomplicated fever in Tanganyika Province, Democratic Republic of the Congo. Clusters (n = 28) of CHWs are randomized to advise caretakers of such children to either 1) return for a follow-up visit on Day 3 following the initial consultation (Day 1), regardless of illness resolution (as per current guidelines) or 2) return for a follow-up visit on Day 3 only if the child's signs have not resolved. Enrolled children are followed up at Day 7 for a repeat assessment and recording of the primary outcome of the study, "failure", which is defined as having fever, diarrhea, pneumonia or decline of health status (e.g. hospitalization, presenting danger signs, or death). Discussion: The results of this trial will be interpreted in conjunction with a similarly designed trial currently ongoing in Ethiopia. If a follow-up visit conditional on continued illness is shown to be non-inferior to current guidelines stipulating universal follow-up, appropriate updating of such guidelines could reduce time and human resource pressures on both providers and caregivers throughout communities of sub-Saharan Africa and South Asia. Trial registration: This trial was registered at ClinicalTrials.gov (NCT02595827) on November 2nd, 2015 Copyright © 2017 The Author(s).
@misc{van_boetzelaer_e._universal_2017,
title = {Universal versus conditional three-day follow up visit for children with uncomplicated fever at the community level: {Design} of a cluster-randomized, community-based, non-inferiority trial in {Tanganyika}, {Democratic} {Republic} of {Congo}},
url = {http://www.biomedcentral.com/bmcpediatr/},
abstract = {Background: The current recommendation within integrated Community Case Management guidelines that all children presenting with uncomplicated fever and no danger signs be followed up after three days may not be necessary. Such fevers often resolve rapidly (usually within 48-96 h), and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aim to determine the non-inferiority of a conditional versus a universal follow-up visit for these children. Methods: We are conducting a cluster-randomized, community-based, non-inferiority trial enrolling {\textasciitilde}4300 children (ages 2-59 months) presenting to community health workers (CHWs) with uncomplicated fever in Tanganyika Province, Democratic Republic of the Congo. Clusters (n = 28) of CHWs are randomized to advise caretakers of such children to either 1) return for a follow-up visit on Day 3 following the initial consultation (Day 1), regardless of illness resolution (as per current guidelines) or 2) return for a follow-up visit on Day 3 only if the child's signs have not resolved. Enrolled children are followed up at Day 7 for a repeat assessment and recording of the primary outcome of the study, "failure", which is defined as having fever, diarrhea, pneumonia or decline of health status (e.g. hospitalization, presenting danger signs, or death). Discussion: The results of this trial will be interpreted in conjunction with a similarly designed trial currently ongoing in Ethiopia. If a follow-up visit conditional on continued illness is shown to be non-inferior to current guidelines stipulating universal follow-up, appropriate updating of such guidelines could reduce time and human resource pressures on both providers and caregivers throughout communities of sub-Saharan Africa and South Asia. Trial registration: This trial was registered at ClinicalTrials.gov (NCT02595827) on November 2nd, 2015 Copyright © 2017 The Author(s).},
journal = {BMC Pediatrics},
author = {{van Boetzelaer E.} and {Ho L.S.} and {Gutman J.R.} and {Steinhardt L.C.} and {Wittcoff A.} and {Barbera Y.} and {Ngoy P.} and {Harvey S.A.} and {Mullany L.C.}},
year = {2017},
keywords = {*Democratic Republic Congo, *Tanzania, *case management, *conditional three day follow up visit, *fever, *follow up, *health auxiliary, *pediatrics, *registration, *uncomplicated fever, *universal follow up visit, Child, Democratic Republic Congo, Ethiopia, South Asia, arm circumference, article, caregiver, clinical assessment, clinical protocol, clinical trial, consultation, controlled clinical trial, controlled study, death, diarrhea, feedback system, female, health auxiliary, health status, hospitalization, human, infant, information processing, major clinical study, male, midupper upper arm circumference, mortality, outcome assessment, patient monitoring, pneumonia, practice guideline, preschool child, quality control, randomization, randomized controlled trial, sample size, study design}
}
Beneficial Effects of Omega-3 Supplement to the Enteral Feeding in Children with Mild to Moderate Sepsis. Al-Biltagi M.A.M., Abo-Elezz A.A.E., Abd-Elhafez M.A., Mabrouk M.M., & Suliman G.A. 2017. abstract bibtex Objective: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Methods: The study was a prospective randomized, double-blind, placebo-controlled study from January 2012 to June 2014, which included 2 groups of children with mild to moderate sepsis tolerating enteral feeding. Group A included 60 children supplemented with omega-3 fatty acids, whereas group B included 60 children who received enteral feeding without omega-3 supplementation. Both groups had complete blood pictures, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum albumin, and IL-6 before and after 7 days from supplementation. Results: There was a significant improvement in hemoglobin percentage (P \textless.0001), total white blood cell (WBC) count (P \textless.0001), and platelet count (P \textless.0001) and significant decrease in CRP (P \textless.0001), ESR (P \textless.0001), IL-6 (P \textless.0001), and albumin level (P \textless.001) in the supplemented group than the nonsupplemented group. The supplemented group also had a significantly shorter duration of stay in pediatric intensive care unit (PICU; P \textless.01) and decreased death rate than the nonsupplemented group. Conclusion: Children with mild to moderate sepsis showed significant improvement in inflammatory markers and had shorter PICU admission when enteral feeding was supplemented with omega-3 essential fatty acids. Copyright © The Author(s) 2015.
@misc{al-biltagi_m.a.m._beneficial_2017,
title = {Beneficial {Effects} of {Omega}-3 {Supplement} to the {Enteral} {Feeding} in {Children} with {Mild} to {Moderate} {Sepsis}},
abstract = {Objective: The objective was to investigate the benefits of supplementing enteral feeding with omega-3 fatty acids in children with mild to moderate sepsis and its effects on acute-phase reactants and interleukin 6 (IL-6) level. Methods: The study was a prospective randomized, double-blind, placebo-controlled study from January 2012 to June 2014, which included 2 groups of children with mild to moderate sepsis tolerating enteral feeding. Group A included 60 children supplemented with omega-3 fatty acids, whereas group B included 60 children who received enteral feeding without omega-3 supplementation. Both groups had complete blood pictures, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum albumin, and IL-6 before and after 7 days from supplementation. Results: There was a significant improvement in hemoglobin percentage (P {\textless}.0001), total white blood cell (WBC) count (P {\textless}.0001), and platelet count (P {\textless}.0001) and significant decrease in CRP (P {\textless}.0001), ESR (P {\textless}.0001), IL-6 (P {\textless}.0001), and albumin level (P {\textless}.001) in the supplemented group than the nonsupplemented group. The supplemented group also had a significantly shorter duration of stay in pediatric intensive care unit (PICU; P {\textless}.01) and decreased death rate than the nonsupplemented group. Conclusion: Children with mild to moderate sepsis showed significant improvement in inflammatory markers and had shorter PICU admission when enteral feeding was supplemented with omega-3 essential fatty acids. Copyright © The Author(s) 2015.},
journal = {Journal of Intensive Care Medicine},
author = {{Al-Biltagi M.A.M.} and {Abo-Elezz A.A.E.} and {Abd-Elhafez M.A.} and {Mabrouk M.M.} and {Suliman G.A.}},
year = {2017},
keywords = {*diet supplementation, *enteric feeding, *erythrocyte sedimentation rate, *interleukin 6, *omega 3 fatty acid/ct [Clinical Trial], *omega 3 fatty acid/dt [Drug Therapy], *sepsis, *sepsis/dt [Drug Therapy], C reactive protein, C reactive protein/ec [Endogenous Compound], Child, acute phase protein, albumin, albumin/ec [Endogenous Compound], article, clinical trial, controlled clinical trial, controlled study, disease severity, docosahexaenoic acid, double blind procedure, drug efficacy, endogenous compound, erythrocyte sedimentation rate, essential fatty acid, female, gene expression, hemoglobin, hemoglobin/ec [Endogenous Compound], human, icosapentaenoic acid, interleukin 6/ec [Endogenous Compound], length of stay, leukocyte count, major clinical study, male, mortality rate, nutritional assessment, omega 3 fatty acid, pediatric intensive care unit, placebo, preschool child, priority journal, prospective study, randomized controlled trial, sepsis/dt [Drug Therapy], serum albumin, thrombocyte count, visually impaired person}
}
A multicenter phase 2 study of empirical low-dose liposomal amphotericin B in patients with refractory febrile neutropenia. Miyao K., Sawa M., Kurata M., Suzuki R., Sakemura R., Sakai T., Kato T., Sahashi S., Tsushita N., Ozawa Y., Tsuzuki M., Kohno A., Adachi T., Watanabe K., Ohbayashi K., Inagaki Y., Atsuta Y., & Emi N. 2017. Paper abstract bibtex Invasive fungal infection (IFI) is a major life-threatening problem encountered by patients with hematological malignancies receiving intensive chemotherapy. Empirical antifungal agents are therefore important. Despite the availability of antifungal agents for such situations, the optimal agents and administration methods remain unclear. We conducted a prospective phase 2 study of empirical 1 mg/kg/day liposomal amphotericin B (L-AMB) in 80 patients receiving intensive chemotherapy for hematological malignancies. All enrolled patients were high-risk and had recurrent prolonged febrile neutropenia despite having received broad-spectrum antibacterial therapy for at least 72 hours. Fifty-three patients (66.3 %) achieved the primary endpoint of successful treatment, thus exceeding the predefined threshold success rate. No patients developed IFI. The treatment completion rate was 73.8 %, and only two cases ceased treatment because of adverse events. The most frequent events were reversible electrolyte abnormalities. We consider low-dose L-AMB to provide comparable efficacy and improved safety and cost-effectiveness when compared with other empirical antifungal therapies. Additional large-scale randomized studies are needed to determine the clinical usefulness of L-AMB relative to other empirical antifungal therapies. Copyright © 2016, The Japanese Society of Hematology.
@misc{miyao_k._multicenter_2017,
title = {A multicenter phase 2 study of empirical low-dose liposomal amphotericin {B} in patients with refractory febrile neutropenia},
url = {http://www.springer.com/west/home?SGWID=4-102-70-173744104-0&changeHeader=true},
abstract = {Invasive fungal infection (IFI) is a major life-threatening problem encountered by patients with hematological malignancies receiving intensive chemotherapy. Empirical antifungal agents are therefore important. Despite the availability of antifungal agents for such situations, the optimal agents and administration methods remain unclear. We conducted a prospective phase 2 study of empirical 1 mg/kg/day liposomal amphotericin B (L-AMB) in 80 patients receiving intensive chemotherapy for hematological malignancies. All enrolled patients were high-risk and had recurrent prolonged febrile neutropenia despite having received broad-spectrum antibacterial therapy for at least 72 hours. Fifty-three patients (66.3 \%) achieved the primary endpoint of successful treatment, thus exceeding the predefined threshold success rate. No patients developed IFI. The treatment completion rate was 73.8 \%, and only two cases ceased treatment because of adverse events. The most frequent events were reversible electrolyte abnormalities. We consider low-dose L-AMB to provide comparable efficacy and improved safety and cost-effectiveness when compared with other empirical antifungal therapies. Additional large-scale randomized studies are needed to determine the clinical usefulness of L-AMB relative to other empirical antifungal therapies. Copyright © 2016, The Japanese Society of Hematology.},
journal = {International Journal of Hematology},
author = {{Miyao K.} and {Sawa M.} and {Kurata M.} and {Suzuki R.} and {Sakemura R.} and {Sakai T.} and {Kato T.} and {Sahashi S.} and {Tsushita N.} and {Ozawa Y.} and {Tsuzuki M.} and {Kohno A.} and {Adachi T.} and {Watanabe K.} and {Ohbayashi K.} and {Inagaki Y.} and {Atsuta Y.} and {Emi N.}},
year = {2017},
keywords = {*amphotericin B lipid complex, *amphotericin B lipid complex/ae [Adverse Drug Reaction], *amphotericin B lipid complex/ct [Clinical Trial], *amphotericin B lipid complex/do [Drug Dose], *amphotericin B lipid complex/dt [Drug Therapy], *amphotericin B lipid complex/iv [Intravenous Drug Administration], *antifungal therapy, *febrile neutropenia, *febrile neutropenia/dt [Drug Therapy], *hematologic malignancy, *recurrent disease/dt [Drug Therapy], Pharmacokinetics, aciclovir, acute lymphoblastic leukemia/dt [Drug Therapy], acute myeloblastic leukemia/dt [Drug Therapy], adolescent, adult, adverse drug reaction, adverse drug reaction/si [Side Effect], aged, antibiotic therapy, antifungal therapy, antineoplastic agent/dt [Drug Therapy], article, cancer chemotherapy, chronic myeloid leukemia/dt [Drug Therapy], congenital malformation, controlled clinical trial, controlled study, cost effectiveness analysis, drug dose increase, drug efficacy, drug safety, drug therapy, electrolyte, febrile neutropenia/dt [Drug Therapy], female, high risk patient, human, infection prevention, intensive care, low drug dose, lymphoma/dt [Drug Therapy], major clinical study, male, multicenter study, multiple myeloma/dt [Drug Therapy], phase 2 clinical trial, prospective study, randomized controlled trial, recurrent disease/dt [Drug Therapy], safety, side effect, systemic mycosis/dt [Drug Therapy], treatment duration}
}
A Systematic Review and Meta-Analysis of Intensive Multidisciplinary Intervention for Pediatric Feeding Disorders: How Standard Is the Standard of Care?. Sharp W.G., Volkert V.M., Scahill L., McCracken C.E., & McElhanon B. 2017. Paper abstract bibtex Objective To assess models of care and conduct a meta-analysis of program outcomes for children receiving intensive, multidisciplinary intervention for pediatric feeding disorders. Study design We searched Medline, PsycINFO, and PubMed databases (2000-2015) in peer-reviewed journals for studies that examined the treatment of children with chronic food refusal receiving intervention at day treatment or inpatient hospital programs. Inclusion criteria required the presentation of quantitative data on food consumption, feeding behavior, and/or growth status before and after intervention. Effect size estimates were calculated based on a meta-analysis of proportions. Results The systematic search yielded 11 studies involving 593 patients. Nine articles presented outcomes based on retrospective (nonrandomized) chart reviews; 2 studies involved randomized controlled trials. All samples involved children with complex medical and/or developmental histories who displayed persistent feeding concerns requiring formula supplementation. Behavioral intervention and tube weaning represented the most common treatment approaches. Core disciplines overseeing care included psychology, nutrition, medicine, and speech-language pathology/occupational therapy. The overall effect size for percentage of patients successfully weaned from tube feeding was 71% (95% CI 54%-83%). Treatment gains endured following discharge, with 80% of patients (95% CI 66%-89%) weaned from tube feeding at last follow-up. Treatment also was associated with increased oral intake, improved mealtime behaviors, and reduced parenting stress. Conclusions Results indicate intensive, multidisciplinary treatment holds benefits for children with severe feeding difficulties. Future research must address key methodological limitations to the extant literature, including improved measurement, more comprehensive case definitions, and standardization/examination of treatment approach. Copyright © 2016 Elsevier Inc.
@misc{sharp_w.g._systematic_2017,
title = {A {Systematic} {Review} and {Meta}-{Analysis} of {Intensive} {Multidisciplinary} {Intervention} for {Pediatric} {Feeding} {Disorders}: {How} {Standard} {Is} the {Standard} of {Care}?},
url = {http://www.elsevier.com/inca/publications/store/6/2/3/3/1/1/index.htt},
abstract = {Objective To assess models of care and conduct a meta-analysis of program outcomes for children receiving intensive, multidisciplinary intervention for pediatric feeding disorders. Study design We searched Medline, PsycINFO, and PubMed databases (2000-2015) in peer-reviewed journals for studies that examined the treatment of children with chronic food refusal receiving intervention at day treatment or inpatient hospital programs. Inclusion criteria required the presentation of quantitative data on food consumption, feeding behavior, and/or growth status before and after intervention. Effect size estimates were calculated based on a meta-analysis of proportions. Results The systematic search yielded 11 studies involving 593 patients. Nine articles presented outcomes based on retrospective (nonrandomized) chart reviews; 2 studies involved randomized controlled trials. All samples involved children with complex medical and/or developmental histories who displayed persistent feeding concerns requiring formula supplementation. Behavioral intervention and tube weaning represented the most common treatment approaches. Core disciplines overseeing care included psychology, nutrition, medicine, and speech-language pathology/occupational therapy. The overall effect size for percentage of patients successfully weaned from tube feeding was 71\% (95\% CI 54\%-83\%). Treatment gains endured following discharge, with 80\% of patients (95\% CI 66\%-89\%) weaned from tube feeding at last follow-up. Treatment also was associated with increased oral intake, improved mealtime behaviors, and reduced parenting stress. Conclusions Results indicate intensive, multidisciplinary treatment holds benefits for children with severe feeding difficulties. Future research must address key methodological limitations to the extant literature, including improved measurement, more comprehensive case definitions, and standardization/examination of treatment approach. Copyright © 2016 Elsevier Inc.},
journal = {Journal of Pediatrics},
author = {{Sharp W.G.} and {Volkert V.M.} and {Scahill L.} and {McCracken C.E.} and {McElhanon B.}},
year = {2017},
keywords = {*child nutrition, *childhood disease/rh [Rehabilitation], *childhood disease/th [Therapy], *enteric feeding, *feeding behavior, *feeding difficulty, *feeding disorder/rh [Rehabilitation], *feeding disorder/th [Therapy], *health care quality, *treatment outcome, *weaning, Child, Medline, PsycINFO, article, clinical outcome, controlled study, effect size, enteric feeding, follow up, food intake, health program, hospital patient, hospitalization, human, human tissue, ideal body weight, medical record review, medicine, meta analysis, model, nutritional counseling, nutritional health, occupational therapy, parental stress, pediatric rehabilitation, priority journal, quantitative study, randomized controlled trial (topic), reinforcement, speech and language rehabilitation, speech disorder, standardization, study design, systematic review, weight reduction}
}
Continuous infusion of apomorphine in patients with advanced Parkinson's disease and different degrees of functional disability. Salazar, G., Martín, J., Fragoso, M., & Font, M. A. Neurología (English Edition), 32(6):407–410, 2017. Paper doi bibtex @article{salazar_continuous_2017,
title = {Continuous infusion of apomorphine in patients with advanced {Parkinson}'s disease and different degrees of functional disability},
volume = {32},
issn = {2173-5808},
url = {http://www.sciencedirect.com/science/article/pii/S2173580817300056},
doi = {10.1016/j.nrleng.2015.10.003},
number = {6},
urldate = {2018-01-16},
journal = {Neurología (English Edition)},
author = {Salazar, G. and Martín, J. and Fragoso, M. and Font, M. A.},
year = {2017},
keywords = {Article, Neurologia},
pages = {407--410},
}
Transcranial direct current stimulation for children with perinatal stroke and hemiparesis. Kirton A., Ciechanski P., Zewdie E., Andersen J., Nettel-Aguirre A., Carlson H., Carsolio L., Herrero M., Quigley J., Mineyko A., Hodge J., & Hill M. 2017. Paper abstract bibtex Objective: To determine whether the addition of transcranial direct current stimulation (tDCS) to intensive therapy increases motor function in children with perinatal stroke and hemiparetic cerebral palsy. Methods: This was a randomized, controlled, double-blind clinical trial. Participants were recruited from a population-based cohort with MRI-classified unilateral perinatal stroke, age of 6 to 18 years, and disabling hemiparesis. All completed a goal-directed, peer-supported, 2-week after-school motor learning camp (32 hours of therapy). Participants were randomized 1:1 to 1 mA cathodal tDCS over the contralesional primary motor cortex (M1) for the initial 20 minutes of daily therapy or sham. Primary subjective (Canadian Occupational Performance Measure [COPM]), objective (Assisting Hand Assessment [AHA]), safety, and secondary outcomes were measured at 1 week and 2 months after intervention. Analysis was by intention to treat. Results: Twenty-four participants were randomized (median age 11.8 +/- 2.7 years, range 6.7-17.8). COPM performance and satisfaction scores doubled at 1 week with sustained gains at 2 months (p \textless 0.001). COPM scores increased more with tDCS compared to sham control (p = 0.004). AHA scores demonstrated only mild increases at both time points with no tDCS effects. Procedures were safe and well tolerated with no decrease in either arm function or serious adverse events. Conclusion: TDCS trials appear feasible and safe in hemiparetic children. Lack of change in objective motor function may reflect underdosing of therapy. Marked gains in subjective function with tDCS warrant further study. ClinicalTrials.gov identifier: NCT02170285. Classification of evidence: This study provides Class II evidence that for children with perinatal stroke and hemiparetic cerebral palsy, the addition of tDCS to moderate-dose motor learning therapy does not significantly improve motor function as measured by the AHA. Copyright © 2016 American Academy of Neurology.
@misc{kirton_a._transcranial_2017,
title = {Transcranial direct current stimulation for children with perinatal stroke and hemiparesis},
url = {http://www.neurology.org},
abstract = {Objective: To determine whether the addition of transcranial direct current stimulation (tDCS) to intensive therapy increases motor function in children with perinatal stroke and hemiparetic cerebral palsy. Methods: This was a randomized, controlled, double-blind clinical trial. Participants were recruited from a population-based cohort with MRI-classified unilateral perinatal stroke, age of 6 to 18 years, and disabling hemiparesis. All completed a goal-directed, peer-supported, 2-week after-school motor learning camp (32 hours of therapy). Participants were randomized 1:1 to 1 mA cathodal tDCS over the contralesional primary motor cortex (M1) for the initial 20 minutes of daily therapy or sham. Primary subjective (Canadian Occupational Performance Measure [COPM]), objective (Assisting Hand Assessment [AHA]), safety, and secondary outcomes were measured at 1 week and 2 months after intervention. Analysis was by intention to treat. Results: Twenty-four participants were randomized (median age 11.8 +/- 2.7 years, range 6.7-17.8). COPM performance and satisfaction scores doubled at 1 week with sustained gains at 2 months (p {\textless} 0.001). COPM scores increased more with tDCS compared to sham control (p = 0.004). AHA scores demonstrated only mild increases at both time points with no tDCS effects. Procedures were safe and well tolerated with no decrease in either arm function or serious adverse events. Conclusion: TDCS trials appear feasible and safe in hemiparetic children. Lack of change in objective motor function may reflect underdosing of therapy. Marked gains in subjective function with tDCS warrant further study. ClinicalTrials.gov identifier: NCT02170285. Classification of evidence: This study provides Class II evidence that for children with perinatal stroke and hemiparetic cerebral palsy, the addition of tDCS to moderate-dose motor learning therapy does not significantly improve motor function as measured by the AHA. Copyright © 2016 American Academy of Neurology.},
journal = {Neurology},
author = {{Kirton A.} and {Ciechanski P.} and {Zewdie E.} and {Andersen J.} and {Nettel-Aguirre A.} and {Carlson H.} and {Carsolio L.} and {Herrero M.} and {Quigley J.} and {Mineyko A.} and {Hodge J.} and {Hill M.}},
year = {2017},
keywords = {*brain ischemia/th [Therapy], *cerebral palsy/th [Therapy], *cerebrovascular accident, *hemiparesis, *hemiparesis/th [Therapy], *perinatal morbidity, *transcranial direct current stimulation, Child, adolescent, adult, adverse drug reaction, adverse outcome, arm movement, article, assisting hand assessment, canadian occupational performance measure, cerebral palsy, classification, clinical article, clinical trial, controlled clinical trial, controlled study, cortical electrode, double blind procedure, female, human, intensive care, intention to treat analysis, male, motor learning, motor performance, neurologic disease assessment, nuclear magnetic resonance imaging, patient safety, peer group, population based case control study, primary motor cortex, priority journal, randomized controlled trial, safety, satisfaction, school child, side effect}
}
Nematode exclusion and recovery in experimental soil microcosms. Franco, A. L. C., Knox, M. A., Andriuzzi, W. S., & de Tomasel, C. M. Soil Biology and Biochemistry, 108:78–83. http://dx.doi.org/10.1016/j.soilbio.2017.02.001, 2017. Paper abstract bibtex Experimental manipulations of soil fauna are a powerful tool for assessing causal relationships between belowground biodiversity and key ecosystem properties. However, preparing soil microcosm treatments without soil fauna for ecological experiments can be problematic. Methods to exclude nematodes, a ubiquitous and functionally important component of terrestrial ecosystems, have been developed for a few specific ecosystems, some of them involving the application of nematicides that may have interactive effects throughout the soil food web. Our goal was to develop a method to remove nematodes from soils of three Long Term Ecological Research (LTER) grassland sites, ranging from desert to moist, without use of chemicals and with moderate disturbance. Moreover, we aimed at testing whether the nematode removal would remain effective up to several weeks later. The following treatments were applied to \textasciitilde3- kg soil microcosms in the laboratory: (1) a 72 h heating (65 C) - freezing (-20 C) - heating (65 C) cycle using soil maintained at its original water content, and pre-wetting soil 24 h before heating (65 C) for either (2A) 48 h or (2B) 24 h.We measured treatment effects on total abundance and trophic structure of the nematode community. To investigate whether nematodes would recolonize eight weeks after treatments, we conducted a greenhouse experiment where individual seedlings of the dominant grass species for each ecosystem were transplanted to treated and non-treated (control) soils. A heat-freezeheat cycle of 72 h using soil in its original field water content killed 60, 95, and 99% of the nematodes for the desert, semi-arid, and moist tallgrass prairie soils, respectively. Pre-wetting soil before heating increased mortality to 99% for all ecosystems after only 24 h at 65 C. Root-feeders were the most resistant nematode trophic group. Eight weeks after treatments, there was no significant nematode recolonization for the pre-wetted 48 h heated soils from the three sites, while for the semi-arid and moist sites there was a slight recovery in abundance in soil from the 24 h heating treatment. Therefore, a treatment at 65 C for 48 h using pre-wetted soil is recommended for eight-week long manipulative experiments in order to assure the effectiveness of the nematode removal throughout the experiment. � 2017 Elsevier Ltd. All rights reserved.
@article{franco_nematode_2017,
title = {Nematode exclusion and recovery in experimental soil microcosms},
volume = {108},
url = {http://dx.doi.org/10.1016/j.soilbio.2017.02.001},
abstract = {Experimental manipulations of soil fauna are a powerful tool for assessing causal relationships between belowground biodiversity and key ecosystem properties. However, preparing soil microcosm treatments without soil fauna for ecological experiments can be problematic. Methods to exclude nematodes, a ubiquitous and functionally important component of terrestrial ecosystems, have been developed for a few specific ecosystems, some of them involving the application of nematicides that may have interactive effects throughout the soil food web. Our goal was to develop a method to remove nematodes from soils of three Long Term Ecological Research (LTER) grassland sites, ranging from desert to moist, without use of chemicals and with moderate disturbance. Moreover, we aimed at testing whether the nematode removal would remain effective up to several weeks later. The following treatments were applied to {\textasciitilde}3- kg soil microcosms in the laboratory: (1) a 72 h heating (65 C) - freezing (-20 C) - heating (65 C) cycle using soil maintained at its original water content, and pre-wetting soil 24 h before heating (65 C) for either (2A) 48 h or (2B) 24 h.We measured treatment effects on total abundance and trophic structure of the nematode community. To investigate whether nematodes would recolonize eight weeks after treatments, we conducted a greenhouse experiment where individual seedlings of the dominant grass species for each ecosystem were transplanted to treated and non-treated (control) soils. A heat-freezeheat cycle of 72 h using soil in its original field water content killed 60, 95, and 99\% of the nematodes for the desert, semi-arid, and moist tallgrass prairie soils, respectively. Pre-wetting soil before heating increased mortality to 99\% for all ecosystems after only 24 h at 65 C. Root-feeders were the most resistant nematode trophic group. Eight weeks after treatments, there was no significant nematode recolonization for the pre-wetted 48 h heated soils from the three sites, while for the semi-arid and moist sites there was a slight recovery in abundance in soil from the 24 h heating treatment. Therefore, a treatment at 65 C for 48 h using pre-wetted soil is recommended for eight-week long manipulative experiments in order to assure the effectiveness of the nematode removal throughout the experiment. � 2017 Elsevier Ltd. All rights reserved.},
journal = {Soil Biology and Biochemistry},
author = {Franco, Andr� L. C. and Knox, Matthew A. and Andriuzzi, Walter S. and de Tomasel, Cecilia M.},
year = {2017},
keywords = {LTER, article, grasslands, intersite, journal, nematode removal, soil defaunation, soil microcosm},
pages = {78--83. http://dx.doi.org/10.1016/j.soilbio.2017.02.001}
}
Sub-Tenon's injection versus paracetamol in pediatric strabismus surgery. Ibrahim A.N. & Shabana T. 2017. Paper abstract bibtex Background: Emergence agitation, vomiting, and oculocardiac reflex (OCR) in children undergoing strabismus surgery under general anesthesia are common problems. The purpose of this study was to determine whether the effect of analgesia can reduce the incidence of these problems. We compared the effects of sub-Tenon's injection versus intravenous (IV) and rectal paracetamol in this surgery. Methods: In a prospective, randomized, double-blind study, ninety patients ranging in age from 4 to 8 years scheduled for extraocular muscle surgery for strabismus were included in this study. After induction of anesthesia, just before the surgery, children were divided into three groups (n = 30 for each group) Group A received sub-Tenon's anesthesia with 2.5% bupivacaine (0.08 ml/kg). Group B received IV paracetamol (20 mg/kg). Group C received paracetamol rectal suppository (40 mg/kg). The occurrence of oculocardiac reflex (OCR) intraoperatively was recorded. Then, in the Postanesthesia Care Unit, patients were assessed for their emergence behaviors. Vomiting was also noticed. Results: The OCR developed in few patients, and there was no significant difference between the groups. The highest number of patients with agitation was in Group C followed by Group B then Group A. Vomiting was significantly low in Group A followed by Group B then Group C. Conclusion: Sub-Tenon block in strabismus surgery in children decreased the incidence of postoperative agitation and vomiting compared with IV paracetamol then rectal paracetamol. There was no difference between sub-Tenon block and paracetamol in the incidence of oculocardiac reflex. Copyright © 2017 Saudi Journal of Anesthesia , Published by Wolters Kluwer - Medknow.
@misc{ibrahim_a.n._sub-tenons_2017,
title = {Sub-{Tenon}'s injection versus paracetamol in pediatric strabismus surgery},
url = {http://www.saudija.org/},
abstract = {Background: Emergence agitation, vomiting, and oculocardiac reflex (OCR) in children undergoing strabismus surgery under general anesthesia are common problems. The purpose of this study was to determine whether the effect of analgesia can reduce the incidence of these problems. We compared the effects of sub-Tenon's injection versus intravenous (IV) and rectal paracetamol in this surgery. Methods: In a prospective, randomized, double-blind study, ninety patients ranging in age from 4 to 8 years scheduled for extraocular muscle surgery for strabismus were included in this study. After induction of anesthesia, just before the surgery, children were divided into three groups (n = 30 for each group) Group A received sub-Tenon's anesthesia with 2.5\% bupivacaine (0.08 ml/kg). Group B received IV paracetamol (20 mg/kg). Group C received paracetamol rectal suppository (40 mg/kg). The occurrence of oculocardiac reflex (OCR) intraoperatively was recorded. Then, in the Postanesthesia Care Unit, patients were assessed for their emergence behaviors. Vomiting was also noticed. Results: The OCR developed in few patients, and there was no significant difference between the groups. The highest number of patients with agitation was in Group C followed by Group B then Group A. Vomiting was significantly low in Group A followed by Group B then Group C. Conclusion: Sub-Tenon block in strabismus surgery in children decreased the incidence of postoperative agitation and vomiting compared with IV paracetamol then rectal paracetamol. There was no difference between sub-Tenon block and paracetamol in the incidence of oculocardiac reflex. Copyright © 2017 Saudi Journal of Anesthesia , Published by Wolters Kluwer - Medknow.},
journal = {Saudi Journal of Anaesthesia},
author = {{Ibrahim A.N.} and {Shabana T.}},
year = {2017},
keywords = {*injection, *paracetamol, *paracetamol/ad [Drug Administration], *paracetamol/ct [Clinical Trial], *paracetamol/iv [Intravenous Drug Administration], *paracetamol/rc [Rectal Drug Administration], *pediatric surgery, *strabismus surgery, *subtenon drug administration, Child, agitation, analgesia, anesthesia induction, antiemetic agent/dt [Drug Therapy], article, behavior, bupivacaine, bupivacaine/ct [Clinical Trial], bupivacaine/io [Intraocular Drug Administration], clinical trial, controlled clinical trial, controlled study, double blind procedure, drug dosage form comparison, extraocular muscle, female, human, major clinical study, male, oculocardiac reflex, outcome assessment, patient monitoring, postoperative agitation/co [Complication], postoperative complication/co [Complication], postoperative vomiting/co [Complication], postoperative vomiting/dt [Drug Therapy], priority journal, prospective study, randomized controlled trial, recovery room, rectal drug administration, rectum, risk reduction, strabismus/su [Surgery], surgery, visually impaired person, vomiting}
}
A PAM50-Based Chemoendocrine Score for Hormone Receptor-Positive Breast Cancer with an Intermediate Risk of Relapse. Prat, A., Lluch, A., Turnbull, A. K., Dunbier, A. K., Calvo, L., Albanell, J., de la Haba-Rodríguez, J., Arcusa, A., Chacón, J. I., Sánchez-Rovira, P., Plazaola, A., Muñoz, M., Paré, L., Parker, J. S., Ribelles, N., Jimenez, B., Bin Aiderus, A. A., Caballero, R., Adamo, B., Dowsett, M., Carrasco, E., Martín, M., Dixon, J. M., Perou, C. M., & Alba, E. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 23(12):3035–3044, 2017. doi abstract bibtex Purpose: Hormone receptor-positive (HR(+)) breast cancer is clinically and biologically heterogeneous, and subgroups with different prognostic and treatment sensitivities need to be identified.Experimental Design: Research-based PAM50 subtyping and expression of additional genes was performed on 63 patients with HR(+)/HER2(-) disease randomly assigned to neoadjuvant multiagent chemotherapy versus endocrine therapy in a phase II trial. The biology associated with treatment response was used to derive a PAM50-based chemoendocrine score (CES). CES's predictive ability was evaluated in 4 independent neoadjuvant data sets (n = 675) and 4 adjuvant data sets (n = 1,505). The association of CES, intrinsic biology, and PAM50 risk of relapse (ROR) was explored across 6,007 tumors.Results: Most genes associated with endocrine sensitivity were also found associated with chemotherapy resistance. In the chemotherapy test/validation data sets, CES was independently associated with pathologic complete response (pCR), even after adjusting for intrinsic subtype. pCR rates of the CES endocrine-sensitive (CES-E), uncertain (CES-U), and chemotherapy-sensitive (CES-C) groups in both data sets combined were 25%, 11%, and 2%, respectively. In the endocrine test/validation data sets, CES was independently associated with response. Compared with ROR, \textgreater90% of ROR-low and ROR-high tumors were identified as CES-E and CES-C, respectively; however, each CES group represented \textgreater25% of ROR-intermediate disease. In terms of survival outcome, CES-C was associated with poor relapse-free survival in patients with ROR-intermediate disease treated with either adjuvant endocrine therapy only or no adjuvant systemic therapy, but not in patients treated with (neo)adjuvant chemotherapy.Conclusions: CES is a genomic signature capable of estimating chemoendocrine sensitivity in HR(+) breast cancer beyond intrinsic subtype and risk of relapse. Clin Cancer Res; 23(12); 3035-44. ©2016 AACR.
@article{prat_pam50-based_2017,
title = {A {PAM50}-{Based} {Chemoendocrine} {Score} for {Hormone} {Receptor}-{Positive} {Breast} {Cancer} with an {Intermediate} {Risk} of {Relapse}},
volume = {23},
issn = {1078-0432},
doi = {10.1158/1078-0432.CCR-16-2092},
abstract = {Purpose: Hormone receptor-positive (HR(+)) breast cancer is clinically and biologically heterogeneous, and subgroups with different prognostic and treatment sensitivities need to be identified.Experimental Design: Research-based PAM50 subtyping and expression of additional genes was performed on 63 patients with HR(+)/HER2(-) disease randomly assigned to neoadjuvant multiagent chemotherapy versus endocrine therapy in a phase II trial. The biology associated with treatment response was used to derive a PAM50-based chemoendocrine score (CES). CES's predictive ability was evaluated in 4 independent neoadjuvant data sets (n = 675) and 4 adjuvant data sets (n = 1,505). The association of CES, intrinsic biology, and PAM50 risk of relapse (ROR) was explored across 6,007 tumors.Results: Most genes associated with endocrine sensitivity were also found associated with chemotherapy resistance. In the chemotherapy test/validation data sets, CES was independently associated with pathologic complete response (pCR), even after adjusting for intrinsic subtype. pCR rates of the CES endocrine-sensitive (CES-E), uncertain (CES-U), and chemotherapy-sensitive (CES-C) groups in both data sets combined were 25\%, 11\%, and 2\%, respectively. In the endocrine test/validation data sets, CES was independently associated with response. Compared with ROR, {\textgreater}90\% of ROR-low and ROR-high tumors were identified as CES-E and CES-C, respectively; however, each CES group represented {\textgreater}25\% of ROR-intermediate disease. In terms of survival outcome, CES-C was associated with poor relapse-free survival in patients with ROR-intermediate disease treated with either adjuvant endocrine therapy only or no adjuvant systemic therapy, but not in patients treated with (neo)adjuvant chemotherapy.Conclusions: CES is a genomic signature capable of estimating chemoendocrine sensitivity in HR(+) breast cancer beyond intrinsic subtype and risk of relapse. Clin Cancer Res; 23(12); 3035-44. ©2016 AACR.},
language = {eng},
number = {12},
journal = {Clinical Cancer Research: An Official Journal of the American Association for Cancer Research},
author = {Prat, Aleix and Lluch, Ana and Turnbull, Arran K. and Dunbier, Anita K. and Calvo, Lourdes and Albanell, Joan and de la Haba-Rodríguez, Juan and Arcusa, Angels and Chacón, José Ignacio and Sánchez-Rovira, Pedro and Plazaola, Arrate and Muñoz, Montserrat and Paré, Laia and Parker, Joel S. and Ribelles, Nuria and Jimenez, Begoña and Bin Aiderus, Abdul Aziz and Caballero, Rosalía and Adamo, Barbara and Dowsett, Mitch and Carrasco, Eva and Martín, Miguel and Dixon, J. Michael and Perou, Charles M. and Alba, Emilio},
year = {2017},
pmid = {27903675},
pmcid = {PMC5449267},
keywords = {Article, Oncologia},
pages = {3035--3044},
}
Are antimicrobial peripherally inserted central catheters associated with reduction in central line-associated bloodstream infection? A systematic review and meta-analysis. Kramer R.D., Rogers M.A.M., Conte M., Mann J., Saint S., & Chopra V. 2017. Paper abstract bibtex Background Antimicrobial peripherally inserted central catheters (PICCs) may reduce the risk of central line-associated bloodstream infection (CLABSI). However, data regarding efficacy are limited. We aimed to evaluate whether antimicrobial PICCs are associated with CLABSI reduction. Methods MEDLINE, EMBASE, CINHAL, and Web of Science were searched from inception to July 2016; conference proceedings were searched to identify additional studies. Study selection and data extraction were performed independently by 2 authors. Results Of 597 citations identified, 8 studies involving 12,879 patients met eligibility criteria. Studies included adult and pediatric patients from intensive care, long-term care, and general ward settings. The incidence of CLABSI in patients with antimicrobial PICCs was 0.2% (95% confidence interval [CI], 0.0%-0.5%), and the incidence among nonantimicrobial catheters was 5.3% (95% CI, 2.6%-8.8%). Compared with noncoated PICCs, antimicrobial PICCs were associated with a significant reduction in CLABSI (relative risk [RR],0.29; 95% CI, 0.10-0.78). Statistical heterogeneity (I2,71.6%; T2=1.07) was resolved by publication type, with peer-reviewed articles showing greater reduction in CLABSI (RR,0.21; 95% CI, 0.06-0.74). Twenty-six patients (95% CI, 21-75) need to be treated with antimicrobial PICCs to prevent 1 CLABSI. Studies of adults at greater baseline risk of CLABSI experienced greater reduction in CLABSI (RR, 0.20; P=.003). Conclusions Available evidence suggests that antimicrobial PICCs may reduce CLABSI, especially in high-risk subgroups. Randomized trials are needed to assess efficacy across patient populations. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc.
@misc{kramer_r.d._are_2017,
title = {Are antimicrobial peripherally inserted central catheters associated with reduction in central line-associated bloodstream infection? {A} systematic review and meta-analysis},
url = {http://www.journals.elsevier.com/ajic-american-journal-of-infection-control/},
abstract = {Background Antimicrobial peripherally inserted central catheters (PICCs) may reduce the risk of central line-associated bloodstream infection (CLABSI). However, data regarding efficacy are limited. We aimed to evaluate whether antimicrobial PICCs are associated with CLABSI reduction. Methods MEDLINE, EMBASE, CINHAL, and Web of Science were searched from inception to July 2016; conference proceedings were searched to identify additional studies. Study selection and data extraction were performed independently by 2 authors. Results Of 597 citations identified, 8 studies involving 12,879 patients met eligibility criteria. Studies included adult and pediatric patients from intensive care, long-term care, and general ward settings. The incidence of CLABSI in patients with antimicrobial PICCs was 0.2\% (95\% confidence interval [CI], 0.0\%-0.5\%), and the incidence among nonantimicrobial catheters was 5.3\% (95\% CI, 2.6\%-8.8\%). Compared with noncoated PICCs, antimicrobial PICCs were associated with a significant reduction in CLABSI (relative risk [RR],0.29; 95\% CI, 0.10-0.78). Statistical heterogeneity (I2,71.6\%; T2=1.07) was resolved by publication type, with peer-reviewed articles showing greater reduction in CLABSI (RR,0.21; 95\% CI, 0.06-0.74). Twenty-six patients (95\% CI, 21-75) need to be treated with antimicrobial PICCs to prevent 1 CLABSI. Studies of adults at greater baseline risk of CLABSI experienced greater reduction in CLABSI (RR, 0.20; P=.003). Conclusions Available evidence suggests that antimicrobial PICCs may reduce CLABSI, especially in high-risk subgroups. Randomized trials are needed to assess efficacy across patient populations. Copyright © 2017 Association for Professionals in Infection Control and Epidemiology, Inc.},
journal = {American Journal of Infection Control},
author = {{Kramer R.D.} and {Rogers M.A.M.} and {Conte M.} and {Mann J.} and {Saint S.} and {Chopra V.}},
year = {2017},
keywords = {*adverse device effect, *antiinfective agent, *antiinfective agent/dt [Drug Therapy], *antimicrobial catheter, *antimicrobial catheter/am [Adverse Device Effect], *antimicrobial therapy, *catheter infection, *catheter infection/co [Complication], *catheter infection/dt [Drug Therapy], *catheter infection/pc [Prevention], *infection prevention, *peripherally inserted central venous catheter, *peripherally inserted central venous catheter/am [Adverse Device Effect], *vein, Child, Cinahl, Embase, Medline, Web of Science, adult, article, catheter infection/dt [Drug Therapy], comparative effectiveness, confidence interval, controlled clinical trial, controlled clinical trial (topic), controlled study, data extraction, disease association, drug therapy, evidence based practice, human, incidence, infection prevention, intensive care, long term care, meta analysis, pediatrics, peer review, prevention, publication, randomized controlled trial, randomized controlled trial(topic), risk factor, risk reduction, systematic review, ward}
}
Aging in HIV-Infected Subjects: A New Scenario and a New View. Negredo, E., Back, D., Blanco, J., Blanco, J., Erlandson, K. M., Garolera, M., Guaraldi, G., Mallon, P., Moltó, J., Serra, J. A., & Clotet, B. BioMed Research International, 2017:5897298, 2017. doi abstract bibtex The prevalence of HIV-infected people aged 50 years or older is increasing rapidly; the proportion will increase from 28% to 73% in 2030. In addition, HIV-infected individuals may be more vulnerable to age-related condition. There is growing evidence that the prevalence of comorbidities and other age-related conditions (geriatric syndromes, functional or neurocognitive/mental problems, polypharmacy, and social difficulties) is higher in the HIV-infected population than in their uninfected counterparts. However, despite the potential impact of this situation on health care, little information exists about the optimal clinical management of older HIV-infected people. Here we examine the age-related conditions in older HIV-infected persons and address clinical management according to author expertise and published literature. Our aim is to advance the debate about the most appropriate management of this population, including less well-studied aspects, such as frequency of screening for psychological/mental and social and functional capabilities.
@article{negredo_aging_2017-1,
title = {Aging in {HIV}-{Infected} {Subjects}: {A} {New} {Scenario} and a {New} {View}},
volume = {2017},
issn = {2314-6141},
shorttitle = {Aging in {HIV}-{Infected} {Subjects}},
doi = {10.1155/2017/5897298},
abstract = {The prevalence of HIV-infected people aged 50 years or older is increasing rapidly; the proportion will increase from 28\% to 73\% in 2030. In addition, HIV-infected individuals may be more vulnerable to age-related condition. There is growing evidence that the prevalence of comorbidities and other age-related conditions (geriatric syndromes, functional or neurocognitive/mental problems, polypharmacy, and social difficulties) is higher in the HIV-infected population than in their uninfected counterparts. However, despite the potential impact of this situation on health care, little information exists about the optimal clinical management of older HIV-infected people. Here we examine the age-related conditions in older HIV-infected persons and address clinical management according to author expertise and published literature. Our aim is to advance the debate about the most appropriate management of this population, including less well-studied aspects, such as frequency of screening for psychological/mental and social and functional capabilities.},
language = {eng},
journal = {BioMed Research International},
author = {Negredo, Eugenia and Back, David and Blanco, José-Ramón and Blanco, Julià and Erlandson, Kristine M. and Garolera, Maite and Guaraldi, Giovanni and Mallon, Patrick and Moltó, José and Serra, José Antonio and Clotet, Bonaventura},
year = {2017},
pmid = {29430462},
pmcid = {PMC5753008},
keywords = {Article, Psiquiatria},
pages = {5897298},
}
Prevention of sudden death in adolescent athletes: Incremental diagnostic value and cost-effectiveness of diagnostic tests. Grazioli, G., Sanz de la Garza, M., Vidal, B., Montserrat, S., Sarquella-Brugada, G., Pi, R., Til, L., Gutierrez, J., Brugada, J., & Sitges, M. European Journal of Preventive Cardiology, 24(13):1446–1454, 2017. doi abstract bibtex Introduction Pre-participation screening in athletes attempts to reduce the incidence of sudden death during sports by identifying susceptible individuals. The objective of this study was to evaluate the diagnostic capacity of the different pre-participation screening points in adolescent athletes and the cost effectiveness of the programme. Methods Athletes were studied between 12-18 years old. Pre-participation screening included the American Heart Association questionnaire, electrocardiogram, echocardiogram, and stress test. The cost of test was established by the Catalan public health system. Results Of 1650 athletes included, 57% were men and mean age was 15.09 ± 1.82 years. Positive findings were identified as follows: in American Heart Association questionnaire 5.09% of subjects, in electrocardiogram 3.78%, in echocardiogram 4.96%, and in exercise test 1.75%. Six athletes (0.36%) were disqualified from participation and 10 (0.60%) were referred for interventional treatment. Diagnostic capacity was assessed by the area under the curve for detection of diseases that motivated disqualification for sport practice (American Heart Association questionnaire, 0.55; electrocardiogram, 0.72; echocardiogram, 0.88; stress test, 0.57). The cost for each athlete disqualified from the sport for a disease causing sudden death was €45,578. Conclusion The electrocardiogram and echocardiogram were the most useful studies to detect athletes susceptible to sudden death, and the stress test best diagnosed arrhythmias with specific treatment. In our country, pre-participatory screening was cost effective to detect athletes who might experience sudden death in sports.
@article{grazioli_prevention_2017,
title = {Prevention of sudden death in adolescent athletes: {Incremental} diagnostic value and cost-effectiveness of diagnostic tests},
volume = {24},
issn = {2047-4881},
shorttitle = {Prevention of sudden death in adolescent athletes},
doi = {10.1177/2047487317713328},
abstract = {Introduction Pre-participation screening in athletes attempts to reduce the incidence of sudden death during sports by identifying susceptible individuals. The objective of this study was to evaluate the diagnostic capacity of the different pre-participation screening points in adolescent athletes and the cost effectiveness of the programme. Methods Athletes were studied between 12-18 years old. Pre-participation screening included the American Heart Association questionnaire, electrocardiogram, echocardiogram, and stress test. The cost of test was established by the Catalan public health system. Results Of 1650 athletes included, 57\% were men and mean age was 15.09 ± 1.82 years. Positive findings were identified as follows: in American Heart Association questionnaire 5.09\% of subjects, in electrocardiogram 3.78\%, in echocardiogram 4.96\%, and in exercise test 1.75\%. Six athletes (0.36\%) were disqualified from participation and 10 (0.60\%) were referred for interventional treatment. Diagnostic capacity was assessed by the area under the curve for detection of diseases that motivated disqualification for sport practice (American Heart Association questionnaire, 0.55; electrocardiogram, 0.72; echocardiogram, 0.88; stress test, 0.57). The cost for each athlete disqualified from the sport for a disease causing sudden death was €45,578. Conclusion The electrocardiogram and echocardiogram were the most useful studies to detect athletes susceptible to sudden death, and the stress test best diagnosed arrhythmias with specific treatment. In our country, pre-participatory screening was cost effective to detect athletes who might experience sudden death in sports.},
language = {eng},
number = {13},
journal = {European Journal of Preventive Cardiology},
author = {Grazioli, Gonzalo and Sanz de la Garza, Maria and Vidal, Barbara and Montserrat, Silvia and Sarquella-Brugada, Georgia and Pi, Ramon and Til, Lluis and Gutierrez, Josep and Brugada, Josep and Sitges, Marta},
year = {2017},
pmid = {28574282},
keywords = {Article, Athletes, CAR Sant Cugat, Sudden death, cost-effectiveness, echocardiogram, electrocardiogram, pre-participation screening, stress test},
pages = {1446--1454},
}
Spanish Clinical Guidelines on Vascular Access for Haemodialysis. Ibeas, J., Roca-Tey, R., Vallespín, J., Moreno, T., Moñux, G., Martí-Monrós, A., Pozo, J. L. D., Gruss, E., Arellano, M. R. d., Fontseré, N., Arenas, M. D., Merino, J. L., García-Revillo, J., Caro, P., López-Espada, C., Giménez-Gaibar, A., Fernández-Lucas, M., Valdés, P., Fernández-Quesada, F., de la Fuente, N., Hernán, D., Arribas, P., de la Nieta, M. D. S., Martínez, M. T., Barba, Á., & por el Grupo Español Multidisciplinar del Acceso Vascular (GEMAV) Nefrologia: Publicacion Oficial De La Sociedad Espanola Nefrologia, 37 Suppl 1:1–193, 2017. doi abstract bibtex Vascular access for haemodialysis is key in renal patients both due to its associated morbidity and mortality and due to its impact on quality of life. The process, from the creation and maintenance of vascular access to the treatment of its complications, represents a challenge when it comes to decision-making, due to the complexity of the existing disease and the diversity of the specialities involved. With a view to finding a common approach, the Spanish Multidisciplinary Group on Vascular Access (GEMAV), which includes experts from the five scientific societies involved (nephrology [S.E.N.], vascular surgery [SEACV], vascular and interventional radiology [SERAM-SERVEI], infectious diseases [SEIMC] and nephrology nursing [SEDEN]), along with the methodological support of the Cochrane Center, has updated the Guidelines on Vascular Access for Haemodialysis, published in 2005. These guidelines maintain a similar structure, in that they review the evidence without compromising the educational aspects. However, on one hand, they provide an update to methodology development following the guidelines of the GRADE system in order to translate this systematic review of evidence into recommendations that facilitate decision-making in routine clinical practice, and, on the other hand, the guidelines establish quality indicators which make it possible to monitor the quality of healthcare.
@article{ibeas_spanish_2017,
title = {Spanish {Clinical} {Guidelines} on {Vascular} {Access} for {Haemodialysis}},
volume = {37 Suppl 1},
issn = {1989-2284},
doi = {10.1016/j.nefro.2017.11.004},
abstract = {Vascular access for haemodialysis is key in renal patients both due to its associated morbidity and mortality and due to its impact on quality of life. The process, from the creation and maintenance of vascular access to the treatment of its complications, represents a challenge when it comes to decision-making, due to the complexity of the existing disease and the diversity of the specialities involved. With a view to finding a common approach, the Spanish Multidisciplinary Group on Vascular Access (GEMAV), which includes experts from the five scientific societies involved (nephrology [S.E.N.], vascular surgery [SEACV], vascular and interventional radiology [SERAM-SERVEI], infectious diseases [SEIMC] and nephrology nursing [SEDEN]), along with the methodological support of the Cochrane Center, has updated the Guidelines on Vascular Access for Haemodialysis, published in 2005. These guidelines maintain a similar structure, in that they review the evidence without compromising the educational aspects. However, on one hand, they provide an update to methodology development following the guidelines of the GRADE system in order to translate this systematic review of evidence into recommendations that facilitate decision-making in routine clinical practice, and, on the other hand, the guidelines establish quality indicators which make it possible to monitor the quality of healthcare.},
language = {eng, spa},
journal = {Nefrologia: Publicacion Oficial De La Sociedad Espanola Nefrologia},
author = {Ibeas, José and Roca-Tey, Ramon and Vallespín, Joaquín and Moreno, Teresa and Moñux, Guillermo and Martí-Monrós, Anna and Pozo, José Luis Del and Gruss, Enrique and Arellano, Manel Ramírez de and Fontseré, Néstor and Arenas, María Dolores and Merino, José Luis and García-Revillo, José and Caro, Pilar and López-Espada, Cristina and Giménez-Gaibar, Antonio and Fernández-Lucas, Milagros and Valdés, Pablo and Fernández-Quesada, Fidel and de la Fuente, Natalia and Hernán, David and Arribas, Patricia and de la Nieta, María Dolores Sánchez and Martínez, María Teresa and Barba, Ángel and {por el Grupo Español Multidisciplinar del Acceso Vascular (GEMAV)}},
year = {2017},
pmid = {29248052},
keywords = {Acceso vascular, Angioplastia, Angioplasty, Arteriovenous fistula, Article, Catéter venoso central, Central venous catheter, Clinical Practice Guidelines, Complicaciones, Complications, Fístula arteriovenosa, GEMAV, GRADE, Guía de práctica clínica, Haemodialysis, Hemodiálisis, Indicadores de calidad, Monitoring, Monitorización, Nefrologia, Quality indicators, Tratamiento, Treatment, Vascular access},
pages = {1--193},
}
Effectiveness of a multimodal exercise rehabilitation program on walking capacity and functionality after a stroke. Grau Pellicer, M. G., Lusar, A. C., Casanovas, J. M., & Ferrer, B. S. Journal of Exercise Rehabilitation, 13(6):666–675, 2017. doi abstract bibtex The aim of this study was to determine the effectiveness of a 12-week multimodal exercise rehabilitation program on walking speed, walking ability and activities of daily living (ADLs) among people who had suffered a stroke. Thirty-one stroke survivors who had completed a conventional rehabilitation program voluntarily participated in the study. Twenty-six participants completed the multimodal exercise rehabilitation program (2 days/wk, 1 hr/session). Physical outcome measures were: walking speed (10-m walking test), walking ability (6-min walking test and functional ambulation classification) and ADLs (Barthel Index). The program consisted on: aerobic exercise; task oriented exercises; balance and postural tonic activities; and stretching. Participants also followed a program of progressive ambulation at home. They were evaluated at baseline, postintervention and at the end of a 6-month follow-up period. After the intervention there were significant improvements in all outcomes measures that were maintained 6 months later. Comfortable and fast walking speed increased an average of 0.16 and 0.40 m/sec, respectively. The walking distance in the 6-min walking test increased an average of 59.8 m. At the end of the intervention, participants had achieved independent ambulation both indoors and outdoors. In ADLs, 40% were independent at baseline vs. 64% at the end of the intervention. Our study demonstrates that a multimodal exercise rehabilitation program adapted to stroke survivors has benefits on walking speed, walking ability and independence in ADLs.
@article{grau_pellicer_effectiveness_2017,
title = {Effectiveness of a multimodal exercise rehabilitation program on walking capacity and functionality after a stroke},
volume = {13},
issn = {2288-176X},
doi = {10.12965/jer.1735056.528},
abstract = {The aim of this study was to determine the effectiveness of a 12-week multimodal exercise rehabilitation program on walking speed, walking ability and activities of daily living (ADLs) among people who had suffered a stroke. Thirty-one stroke survivors who had completed a conventional rehabilitation program voluntarily participated in the study. Twenty-six participants completed the multimodal exercise rehabilitation program (2 days/wk, 1 hr/session). Physical outcome measures were: walking speed (10-m walking test), walking ability (6-min walking test and functional ambulation classification) and ADLs (Barthel Index). The program consisted on: aerobic exercise; task oriented exercises; balance and postural tonic activities; and stretching. Participants also followed a program of progressive ambulation at home. They were evaluated at baseline, postintervention and at the end of a 6-month follow-up period. After the intervention there were significant improvements in all outcomes measures that were maintained 6 months later. Comfortable and fast walking speed increased an average of 0.16 and 0.40 m/sec, respectively. The walking distance in the 6-min walking test increased an average of 59.8 m. At the end of the intervention, participants had achieved independent ambulation both indoors and outdoors. In ADLs, 40\% were independent at baseline vs. 64\% at the end of the intervention. Our study demonstrates that a multimodal exercise rehabilitation program adapted to stroke survivors has benefits on walking speed, walking ability and independence in ADLs.},
language = {eng},
number = {6},
journal = {Journal of Exercise Rehabilitation},
author = {Grau Pellicer, Montserrat Grau and Lusar, Andrés Chamarro and Casanovas, Josep Medina and Ferrer, Bernat-Carles Serdà},
year = {2017},
pmid = {29326899},
pmcid = {PMC5747202},
keywords = {Activities of daily living, Article, Exercise, Physical activity, Rehabilitació, Stroke rehabilitation, Walking speed},
pages = {666--675},
}
Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?. Torres-Santiago L., Mauras N., Hossain J., Weltman A.L., & Darmaun D. 2017. Paper abstract bibtex Objective The decline in insulin sensitivity (SI) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing SI in adolescents with T1D. Methods Thirteen adolescents with T1D (HbA1C 8.2 +/- 0.1%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning. Results Blood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50% versus 33%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 +/- 1 mg * kg-1 * min-1 versus 7.0 +/- 1; glutamine versus placebo; P = 0.4). Conclusions Oral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed. Copyright © 2016 Elsevier Inc.
@misc{torres-santiago_l._does_2017,
title = {Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?},
url = {http://www.elsevier.com/locate/nut},
abstract = {Objective The decline in insulin sensitivity (SI) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing SI in adolescents with T1D. Methods Thirteen adolescents with T1D (HbA1C 8.2 +/- 0.1\%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning. Results Blood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50\% versus 33\%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 +/- 1 mg * kg-1 * min-1 versus 7.0 +/- 1; glutamine versus placebo; P = 0.4). Conclusions Oral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed. Copyright © 2016 Elsevier Inc.},
journal = {Nutrition},
author = {{Torres-Santiago L.} and {Mauras N.} and {Hossain J.} and {Weltman A.L.} and {Darmaun D.}},
year = {2017},
keywords = {*clamp, *glucagon like peptide 1, *glutamine, *glutamine/ae [Adverse Drug Reaction], *glutamine/cm [Drug Comparison], *glutamine/dt [Drug Therapy], *glutamine/po [Oral Drug Administration], *hyperinsulinism, *hypoglycemia, *insulin dependent diabetes mellitus, *insulin dependent diabetes mellitus/dt [Drug Therapy], *insulin sensitivity, *isotope, *treadmill, adolescent, antidiabetic agent, article, blood glucose monitoring, body mass, carbohydrate intake, clinical article, clinical trial, controlled clinical trial, controlled study, crossover procedure, disease duration, double blind procedure, exercise, fatty acid/ec [Endogenous Compound], female, glucagon like peptide 1/ec [Endogenous Compound], gluconeogenesis, glucose blood level, glucose homeostasis, glucose infusion, glucose metabolism, glucose tolerance, glycemic control, glycogen synthesis, hemoglobin A1c, hemoglobin A1c/ec [Endogenous Compound], human, hyperinsulinemic euglycemic clamp technique, hypoglycemia/si [Side Effect], incidence, insulin dependent diabetes mellitus/dt [Drug Therapy], insulin resistance, lipolysis, male, placebo, priority journal, probability, puberty, randomized controlled trial, rest, sex ratio, treadmill exercise}
}
Short-term outcome of percutaneous tibial nerve stimulation for low anterior resection syndrome: results of a pilot study. Altomare, D. F., Picciariello, A., Ferrara, C., Digennaro, R., Ribas, Y., & De Fazio, M. Colorectal Disease: The Official Journal of the Association of Coloproctology of Great Britain and Ireland, 19(9):851–856, 2017. doi abstract bibtex AIM: Percutaneous tibial nerve stimulation (PTNS) is a minimally invasive procedure which has been demonstrated to be effective in faecal/urinary incontinence but has never been tested in low anterior resection syndrome (LARS). The severity of LARS may be evaluated by the LARS score, but rectal cancer treatments may also affect urinary and sexual function, which are not explored by the LARS score. The Three Axial Perineal Evaluation (TAPE) score is a new validated index addressing the overall pelvic floor functions. This study aims to assess the efficacy of PTNS in LARS patients and to evaluate the results by the LARS and TAPE scores. METHODS: Twenty-one patients operated on for rectal cancer between 2009 and 2014 complaining of LARS underwent PTNS (12 sessions of 30 min each). Six patients reported urinary incontinence and all except two (men) were sexually inactive. The LARS score and the TAPE score questionnaires were administered at baseline and after 6 months of follow-up. RESULTS: At 6 months' follow-up, nine patients reported a significant improvement of faecal incontinence and 3/6 an improvement of urinary incontinence after PTNS. Median LARS score significantly decreased from 32 to 27 (P = 0.009), while the median TAPE score improved significantly from 55 to 58 (P = 0.004). CONCLUSIONS: PTNS may be a further option in the treatment of selected patients with LARS and in addition may improve associated urinary incontinence. The severity of LARS can be detected by the LARS score; however, the adoption of the TAPE score is preferred in the case of concomitant urinary and/or sexual problems not explored by the LARS score.
@article{altomare_short-term_2017,
title = {Short-term outcome of percutaneous tibial nerve stimulation for low anterior resection syndrome: results of a pilot study},
volume = {19},
issn = {1463-1318},
shorttitle = {Short-term outcome of percutaneous tibial nerve stimulation for low anterior resection syndrome},
doi = {10.1111/codi.13669},
abstract = {AIM: Percutaneous tibial nerve stimulation (PTNS) is a minimally invasive procedure which has been demonstrated to be effective in faecal/urinary incontinence but has never been tested in low anterior resection syndrome (LARS). The severity of LARS may be evaluated by the LARS score, but rectal cancer treatments may also affect urinary and sexual function, which are not explored by the LARS score. The Three Axial Perineal Evaluation (TAPE) score is a new validated index addressing the overall pelvic floor functions. This study aims to assess the efficacy of PTNS in LARS patients and to evaluate the results by the LARS and TAPE scores.
METHODS: Twenty-one patients operated on for rectal cancer between 2009 and 2014 complaining of LARS underwent PTNS (12 sessions of 30 min each). Six patients reported urinary incontinence and all except two (men) were sexually inactive. The LARS score and the TAPE score questionnaires were administered at baseline and after 6 months of follow-up.
RESULTS: At 6 months' follow-up, nine patients reported a significant improvement of faecal incontinence and 3/6 an improvement of urinary incontinence after PTNS. Median LARS score significantly decreased from 32 to 27 (P = 0.009), while the median TAPE score improved significantly from 55 to 58 (P = 0.004).
CONCLUSIONS: PTNS may be a further option in the treatment of selected patients with LARS and in addition may improve associated urinary incontinence. The severity of LARS can be detected by the LARS score; however, the adoption of the TAPE score is preferred in the case of concomitant urinary and/or sexual problems not explored by the LARS score.},
language = {eng},
number = {9},
journal = {Colorectal Disease: The Official Journal of the Association of Coloproctology of Great Britain and Ireland},
author = {Altomare, D. F. and Picciariello, A. and Ferrara, C. and Digennaro, R. and Ribas, Y. and De Fazio, M.},
year = {2017},
pmid = {28371160},
keywords = {Article, Cirurgia, Faecal incontinence, Low anterior resection syndrome, Rectal cancer, obstructed defaecation, pelvic floor function, posterior tibial nerve stimulation},
pages = {851--856},
}
Spatial relationship of i-gel and Ambu AuraOnceTM on pediatric airway: A randomized comparison based on three dimensional magnetic resonance imaging. Aqil M., Delvi B., Abujamea A., Alzahrani T., Alzahem A., Mansoor S., & Aljazaeri A. 2017. Paper abstract bibtex BACKGROUND: Gross morphological differences exist among different brands of pediatric supraglottic devices (SGDs). The aim of this study is to compare the spatial relationship of i-gel and Ambu AuraOnce (AO)TM on pediatric airway based on three dimensional (3-D) magnetic resonance imaging (MRI) measurements. METHODS: Sixty patients up to 12 years of age were enrolled and assigned in two groups, i-gel or Ambu AOTM. After confirmation of proper placement of these SGDs, 3-D MRI scans of head and neck were performed. Another native scan was also obtained after removal of the SGD for comparison. RESULTS: i-gel produced significant degree of compression of the tongue (P\textless0.001) while Ambu AOTM significantly reduced the axial diameter of glottis (P=0.033) compared to their native values. Both i-gel and Ambu AOTM significantly reduced the area of the glottic opening (P\textless0.001 for each device) and the distance between the arytenoids (P\textless0.001 and P=0.007 respectively); and increased the distance between the hyoid bone and cervical spine (P\textless0.001 and P=0.001 respectively) in comparison to their corresponding native values. Bowl of i-gel produced greater dilation of the upper esophageal sphincter at all levels of measurement- upper (P\textless0.001), middle (P=0.001) and lower (P=0.015) in comparison to Ambu AOTM. CONCLUSION: Based on 3-D MRImeasurements done on living patients, both SGDs distorted the anatomy of pediatric airway compared to their respective native values to variable extent. The relevance of these effects needs further studies on larger patient group in order to reduce morbidity on pediatric airway. Copyright © 2016 EDIZIONIMINERVAMEDICA.
@misc{aqil_m._spatial_2017,
title = {Spatial relationship of i-gel and {Ambu} {AuraOnceTM} on pediatric airway: {A} randomized comparison based on three dimensional magnetic resonance imaging},
url = {http://www.minervamedica.it/en/getpdf/SbYx%252Btlz%252BJWUd%252FmVZvSrwVkDh1DadpDCSDnMLnLvexqh7zF1qTAUPIT%252BNUCgp8zfs5o1AvscN5dfbzrHJlXQsw%253D%253D/R02Y2017N01A0023.pdf},
abstract = {BACKGROUND: Gross morphological differences exist among different brands of pediatric supraglottic devices (SGDs). The aim of this study is to compare the spatial relationship of i-gel and Ambu AuraOnce (AO)TM on pediatric airway based on three dimensional (3-D) magnetic resonance imaging (MRI) measurements. METHODS: Sixty patients up to 12 years of age were enrolled and assigned in two groups, i-gel or Ambu AOTM. After confirmation of proper placement of these SGDs, 3-D MRI scans of head and neck were performed. Another native scan was also obtained after removal of the SGD for comparison. RESULTS: i-gel produced significant degree of compression of the tongue (P{\textless}0.001) while Ambu AOTM significantly reduced the axial diameter of glottis (P=0.033) compared to their native values. Both i-gel and Ambu AOTM significantly reduced the area of the glottic opening (P{\textless}0.001 for each device) and the distance between the arytenoids (P{\textless}0.001 and P=0.007 respectively); and increased the distance between the hyoid bone and cervical spine (P{\textless}0.001 and P=0.001 respectively) in comparison to their corresponding native values. Bowl of i-gel produced greater dilation of the upper esophageal sphincter at all levels of measurement- upper (P{\textless}0.001), middle (P=0.001) and lower (P=0.015) in comparison to Ambu AOTM. CONCLUSION: Based on 3-D MRImeasurements done on living patients, both SGDs distorted the anatomy of pediatric airway compared to their respective native values to variable extent. The relevance of these effects needs further studies on larger patient group in order to reduce morbidity on pediatric airway. Copyright © 2016 EDIZIONIMINERVAMEDICA.},
journal = {Minerva Anestesiologica},
author = {{Aqil M.} and {Delvi B.} and {Abujamea A.} and {Alzahrani T.} and {Alzahem A.} and {Mansoor S.} and {Aljazaeri A.}},
year = {2017},
keywords = {*laryngeal mask, *nuclear magnetic resonance imaging, *pediatric face mask, *respiration control, Child, anatomy, article, cervical spine, comparative study, compression, controlled clinical trial, controlled study, electrocardiography, female, glottis, human, hyoid bone, intermethod comparison, larynx cartilage, major clinical study, male, morbidity, preschool child, prospective study, randomized controlled trial, school child, supraglottic airway device, tongue, upper esophagus sphincter}
}
Effectiveness of airway clearance techniques in children hospitalized with acute bronchiolitis. Van Ginderdeuren F., Vandenplas Y., Deneyer M., Vanlaethem S., Buyl R., & Kerckhofs E. 2017. Paper abstract bibtex Objective: To evaluate the effectiveness of two airway clearance techniques (ACT's) in children \textless24 months hospitalized with mild to moderate bronchiolitis. Design: One hundred and three children were randomly allocated to receive one 20-min session daily, either assisted autogenic drainage (AAD), intrapulmonary percussive ventilation (IPV), or bouncing (B) (control group), ninety-three finished the study. Outcome measures: Mean time to recovery in days was our primary outcome measure. The impact of the treatment and the daily improvement was also assessed by a validated clinical and respiratory severity score (WANG score), heart rate (HR), and oxygen saturation (SaO2). Results: Mean time to recovery was 4.5 +/- 1.9 days for the control group, 3.6 +/- 1.4 days, P \textless 0.05 for the AAD group and 3.5 +/- 1.3 days, P = 0.03 for the IPV group. Wang scores improved significantly for both physiotherapy techniques compared to the control group. Conclusion: Both ACT's reduced significantly the length of hospital stay compared to no physiotherapy. Pediatr Pulmonol. 2017;52:225-231. © 2016 Wiley Periodicals, Inc. Copyright © 2016 Wiley Periodicals, Inc.
@misc{van_ginderdeuren_f._effectiveness_2017,
title = {Effectiveness of airway clearance techniques in children hospitalized with acute bronchiolitis},
url = {http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0496},
abstract = {Objective: To evaluate the effectiveness of two airway clearance techniques (ACT's) in children {\textless}24 months hospitalized with mild to moderate bronchiolitis. Design: One hundred and three children were randomly allocated to receive one 20-min session daily, either assisted autogenic drainage (AAD), intrapulmonary percussive ventilation (IPV), or bouncing (B) (control group), ninety-three finished the study. Outcome measures: Mean time to recovery in days was our primary outcome measure. The impact of the treatment and the daily improvement was also assessed by a validated clinical and respiratory severity score (WANG score), heart rate (HR), and oxygen saturation (SaO2). Results: Mean time to recovery was 4.5 +/- 1.9 days for the control group, 3.6 +/- 1.4 days, P {\textless} 0.05 for the AAD group and 3.5 +/- 1.3 days, P = 0.03 for the IPV group. Wang scores improved significantly for both physiotherapy techniques compared to the control group. Conclusion: Both ACT's reduced significantly the length of hospital stay compared to no physiotherapy. Pediatr Pulmonol. 2017;52:225-231. © 2016 Wiley Periodicals, Inc. Copyright © 2016 Wiley Periodicals, Inc.},
journal = {Pediatric Pulmonology},
author = {{Van Ginderdeuren F.} and {Vandenplas Y.} and {Deneyer M.} and {Vanlaethem S.} and {Buyl R.} and {Kerckhofs E.}},
year = {2017},
keywords = {*assisted autogenic drainage, *breathing exercise, *bronchiolitis, *bronchiolitis/th [Therapy], *hospital patient, *intrapulmonary percussive ventilation, *lung clearance, Child, WANG score, arterial oxygen saturation, article, artificial ventilation, clinical effectiveness, control group, controlled clinical trial, controlled study, disease severity, disease severity assessment, female, heart rate, hospitalization, human, infant, length of stay, major clinical study, male, outcome assessment, oxygen saturation, randomized controlled trial}
}
Transdermal rivastigmine for HIV-associated cognitive impairment: A randomized pilot study. Muñoz-Moreno, J. A., Prats, A., Moltó, J., Garolera, M., Pérez-Álvarez, N., Díez-Quevedo, C., Miranda, C., Fumaz, C. R., Ferrer, M. J., Clotet, B., & TRIANT-TE Study Group PloS One, 12(8):e0182547, 2017. doi abstract bibtex OBJECTIVE: To assess the efficacy and safety of transdermal rivastigmine for the treatment of HIV-associated cognitive impairment. METHODS: We recruited HIV-infected patients with cognitive impairment on stable antiretroviral therapy in a randomized controlled pilot trial with a 48-week follow-up. An additional assessment was held at 12 weeks. Participants received transdermal rivastigmine (9.5 mg daily), lithium (400 mg twice daily, titrated progressively), or remained in a control group (no new medication). The primary efficacy endpoint was change in a global cognitive score (NPZ-7). Secondary endpoints included change in specific cognitive measures, domains, and functional parameters. Safety covered the frequency of adverse events and changes in laboratory results. RESULTS: Seventy-six subjects were screened, and 29 were finally enrolled. Better cognitive outcomes were observed in all groups, although there were no significant differences between the arms (mean NPZ-7 change [SD]): rivastigmine, 0.35 (0.14); lithium, 0.25 (0.40); control, 0.20 (0.44) (p = 0.78). The rivastigmine group showed the highest positive trend (mean NPZ-7 [SD], baseline vs week 48): rivastigmine, -0.47 (0.22) vs -0.11 (0.29), p = 0.06; lithium, -0.50 (0.40) vs -0.26 (0.21), p = 0.22; control, -0.52 (0.34) vs -0.32 (0.52), p = 0.44. The cognitive domains with the highest positive trends were information processing speed at week 12 and executive function at week 48 (rivastigmine vs control): information processing speed, 0.35 (0.64) vs -0.13 (0.25), p = 0.17, d = 0.96; and executive functioning, 0.73 (0.33) vs 0.03 (0.74), p = 0.09, d = 1.18. No relevant changes were observed regarding functional outcomes. A total of 12 (41%) individuals dropped out of the study: 2 (20%) were due to medication-related effects in the rivastigmine group and 4 (36%) in the lithium group. No severe adverse events were reported. CONCLUSIONS: The results from this small randomized trial indicate that transdermal rivastigmine did not provide significant cognitive benefits in people with HAND on stable antiretroviral therapy, even though positive trends were found in specific cognitive domains. Relevant tolerability issues were not observed.
@article{munoz-moreno_transdermal_2017,
title = {Transdermal rivastigmine for {HIV}-associated cognitive impairment: {A} randomized pilot study},
volume = {12},
issn = {1932-6203},
shorttitle = {Transdermal rivastigmine for {HIV}-associated cognitive impairment},
doi = {10.1371/journal.pone.0182547},
abstract = {OBJECTIVE: To assess the efficacy and safety of transdermal rivastigmine for the treatment of HIV-associated cognitive impairment.
METHODS: We recruited HIV-infected patients with cognitive impairment on stable antiretroviral therapy in a randomized controlled pilot trial with a 48-week follow-up. An additional assessment was held at 12 weeks. Participants received transdermal rivastigmine (9.5 mg daily), lithium (400 mg twice daily, titrated progressively), or remained in a control group (no new medication). The primary efficacy endpoint was change in a global cognitive score (NPZ-7). Secondary endpoints included change in specific cognitive measures, domains, and functional parameters. Safety covered the frequency of adverse events and changes in laboratory results.
RESULTS: Seventy-six subjects were screened, and 29 were finally enrolled. Better cognitive outcomes were observed in all groups, although there were no significant differences between the arms (mean NPZ-7 change [SD]): rivastigmine, 0.35 (0.14); lithium, 0.25 (0.40); control, 0.20 (0.44) (p = 0.78). The rivastigmine group showed the highest positive trend (mean NPZ-7 [SD], baseline vs week 48): rivastigmine, -0.47 (0.22) vs -0.11 (0.29), p = 0.06; lithium, -0.50 (0.40) vs -0.26 (0.21), p = 0.22; control, -0.52 (0.34) vs -0.32 (0.52), p = 0.44. The cognitive domains with the highest positive trends were information processing speed at week 12 and executive function at week 48 (rivastigmine vs control): information processing speed, 0.35 (0.64) vs -0.13 (0.25), p = 0.17, d = 0.96; and executive functioning, 0.73 (0.33) vs 0.03 (0.74), p = 0.09, d = 1.18. No relevant changes were observed regarding functional outcomes. A total of 12 (41\%) individuals dropped out of the study: 2 (20\%) were due to medication-related effects in the rivastigmine group and 4 (36\%) in the lithium group. No severe adverse events were reported.
CONCLUSIONS: The results from this small randomized trial indicate that transdermal rivastigmine did not provide significant cognitive benefits in people with HAND on stable antiretroviral therapy, even though positive trends were found in specific cognitive domains. Relevant tolerability issues were not observed.},
language = {eng},
number = {8},
journal = {PloS One},
author = {Muñoz-Moreno, Jose A. and Prats, Anna and Moltó, José and Garolera, Maite and Pérez-Álvarez, Núria and Díez-Quevedo, Crisanto and Miranda, Cristina and Fumaz, Carmina R. and Ferrer, Maria J. and Clotet, Bonaventura and {TRIANT-TE Study Group}},
year = {2017},
pmid = {28854283},
keywords = {Article, Psiquiatria},
pages = {e0182547},
}