2019 (2)
Schurz, H.; Müller, S. J.; van Helden, P. D.; Tromp, G.; Hoal, E. G.; Kinnear, C. J.; and Möller, M. Evaluating the Accuracy of Imputation Methods in a Five-Way Admixed Population. Frontiers in Genetics, 10: 34. 2019.
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Schurz, H.; Salie, M.; Tromp, G.; Hoal, E. G.; Kinnear, C. J.; and Möller, M. The X chromosome and sex-specific effects in infectious disease susceptibility. Human Genomics, 13(1): 2. January 2019.
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  2018 (12)
Schurz, H.; Kinnear, C. J.; Gignoux, C.; Wojcik, G.; van Helden, P. D.; Tromp, G.; Henn, B.; Hoal, E. G.; and Möller, M. A Sex-Stratified Genome-Wide Association Study of Tuberculosis Using a Multi-Ethnic Genotyping Array. Frontiers in Genetics, 9: 678. 2018.
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Neethling, A.; Engelbrecht, L.; Loos, B.; Kinnear, C.; Theart, R.; Abrahams, S.; Niesler, T.; Mellick, G. D.; Williams, M.; and Bardien, S. Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex. Experimental Cell Research. December 2018.
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Lin, M.; Siford, R. L.; Martin, A. R.; Nakagome, S.; Möller, M.; Hoal, E. G.; Bustamante, C. D.; Gignoux, C. R.; and Henn, B. M. Rapid evolution of a skin-lightening allele in southern African KhoeSan. Proceedings of the National Academy of Sciences of the United States of America, 115(52): 13324–13329. December 2018.
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Möller, M.; Kinnear, C. J.; Orlova, M.; Kroon, E. E.; van Helden, P. D.; Schurr, E.; and Hoal, E. G. Genetic Resistance to Mycobacterium tuberculosis Infection and Disease. Frontiers in Immunology, 9: 2219. 2018.
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Kroon, E. E.; Coussens, A. K.; Kinnear, C.; Orlova, M.; Möller, M.; Seeger, A.; Wilkinson, R. J.; Hoal, E. G.; and Schurr, E. Neutrophils: Innate Effectors of TB Resistance?. Frontiers in Immunology, 9: 2637. 2018.
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Tavalire, H. F.; Beechler, B. R.; Buss, P. E.; Gorsich, E. E.; Hoal, E. G.; le Roex, N.; Spaan, J. M.; Spaan, R. S.; van Helden, P. D.; Ezenwa, V. O.; and Jolles, A. E. Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host. Ecology and Evolution, 8(24): 12712–12726. December 2018.
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Martin, A. R.; Teferra, S.; Möller, M.; Hoal, E. G.; and Daly, M. J. The critical needs and challenges for genetic architecture studies in Africa. Current Opinion in Genetics & Development, 53: 113–120. September 2018.
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Glanzmann, B.; Uren, C.; de Villiers, N.; van Coller, A.; Glashoff, R. H.; Urban, M.; Hoal, E. G.; Esser, M. M.; Möller, M.; and Kinnear, C. J. Primary immunodeficiency diseases in a tuberculosis endemic region: challenges and opportunities. Genes and Immunity. September 2018.
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Nemat-Gorgani, N.; Hilton, H. G.; Henn, B. M.; Lin, M.; Gignoux, C. R.; Myrick, J. W.; Werely, C. J.; Granka, J. M.; Möller, M.; Hoal, E. G.; Yawata, M.; Yawata, N.; Boelen, L.; Asquith, B.; Parham, P.; and Norman, P. J. Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2+ HLA-C in Two Indigenous Human Populations in Southern Africa. Journal of Immunology (Baltimore, Md.: 1950), 200(8): 2640–2655. April 2018.
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Colli, L.; Milanesi, M.; Vajana, E.; Iamartino, D.; Bomba, L.; Puglisi, F.; Del Corvo, M.; Nicolazzi, E. L.; Ahmed, S. S. E.; Herrera, J. R. V.; Cruz, L.; Zhang, S.; Liang, A.; Hua, G.; Yang, L.; Hao, X.; Zuo, F.; Lai, S.; Wang, S.; Liu, R.; Gong, Y.; Mokhber, M.; Mao, Y.; Guan, F.; Vlaic, A.; Vlaic, B.; Ramunno, L.; Cosenza, G.; Ahmad, A.; Soysal, I.; Ünal, E. Ö; Ketudat-Cairns, M.; Garcia, J. F.; Utsunomiya, Y. T.; Baruselli, P. S.; Amaral, M. E. J.; Parnpai, R.; Drummond, M. G.; Galbusera, P.; Burton, J.; Hoal, E.; Yusnizar, Y.; Sumantri, C.; Moioli, B.; Valentini, A.; Stella, A.; Williams, J. L.; and Ajmone-Marsan, P. New Insights on Water Buffalo Genomic Diversity and Post-Domestication Migration Routes From Medium Density SNP Chip Data. Frontiers in Genetics, 9: 53. 2018.
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Glanzmann, B.; Möller, M.; Moncada-Velez, M.; Peter, J.; Urban, M.; van Helden, P. D.; Hoal, E. G.; de Villiers, N.; Glashoff, R. H.; Nortje, R.; Bustamante, J.; Abel, L.; Casanova, J.; Boisson-Dupuis, S.; Esser, M.; and Kinnear, C. J. Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacteriosis and Tuberculosis in a BCG-Vaccinated South African Patient. Journal of Clinical Immunology. May 2018.
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McGregor, N. W.; Dimatelis, J. J.; Van Zyl, P. J.; Hemmings, S. M. J.; Kinnear, C.; Russell, V. A.; Stein, D. J.; and Lochner, C. A translational approach to the genetics of anxiety disorders. Behavioural Brain Research, 341: 91–97. April 2018.
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  2017 (14)
De Wet, J.; Jordaan, H. F.; Kannenberg, S. M.; Tod, B.; Glanzmann, B.; and Visser, W. I. Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab. Dermatology Online Journal, 23(12). December 2017.
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Kannan, M.; Bayam, E.; Wagner, C.; Rinaldi, B.; Kretz, P. F.; Tilly, P.; Roos, M.; McGillewie, L.; Bär, S.; Minocha, S.; Chevalier, C.; Po, C.; Sanger Mouse Genetics Project; Chelly, J.; Mandel, J.; Borgatti, R.; Piton, A.; Kinnear, C.; Loos, B.; Adams, D. J.; Hérault, Y.; Collins, S. C.; Friant, S.; Godin, J. D.; and Yalcin, B. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proceedings of the National Academy of Sciences of the United States of America, 114(44): E9308–E9317. October 2017.
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Kinnear, C.; Hoal, E. G.; Schurz, H.; van Helden, P. D.; and Möller, M. The role of human host genetics in tuberculosis resistance. Expert Review of Respiratory Medicine, 11(9): 721–737. September 2017.
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Hoal, E. G.; Dippenaar, A.; Kinnear, C.; van Helden, P. D.; and Möller, M. The arms race between man and Mycobacterium tuberculosis: Time to regroup. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. August 2017.
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Jabot-Hanin, F.; Cobat, A.; Feinberg, J.; Orlova, M.; Niay, J.; Deswarte, C.; Poirier, C.; Theodorou, I.; Bustamante, J.; Boisson-Dupuis, S.; Casanova, J.; Alcaïs, A.; Hoal, E. G.; Delacourt, C.; Schurr, E.; and Abel, L. An eQTL variant of ZXDC is associated with IFN-γ production following Mycobacterium tuberculosis antigen-specific stimulation. Scientific Reports, 7(1): 12800. October 2017.
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Martin, A. R.; Lin, M.; Granka, J. M.; Myrick, J. W.; Liu, X.; Sockell, A.; Atkinson, E. G.; Werely, C. J.; Möller, M.; Sandhu, M. S.; Kingsley, D. M.; Hoal, E. G.; Liu, X.; Daly, M. J.; Feldman, M. W.; Gignoux, C. R.; Bustamante, C. D.; and Henn, B. M. An Unexpectedly Complex Architecture for Skin Pigmentation in Africans. Cell, 171(6): 1340–1353.e14. November 2017.
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Schlechter, N.; Glanzmann, B.; Hoal, E. G.; Schoeman, M.; Petersen, B.; Franke, A.; Lau, Y.; Urban, M.; van Helden, P. D.; Esser, M. M.; Möller, M.; and Kinnear, C. Exome Sequencing Identifies a NovelMAP3K14Mutation in Recessive Atypical Combined Immunodeficiency. Frontiers in Immunology, 8: 1624. 2017.
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Uren, C.; Möller, M.; van Helden, P. D.; Henn, B. M.; and Hoal, E. G. Population structure and infectious disease risk in southern Africa. Molecular genetics and genomics: MGG, 292(3): 499–509. June 2017. 00000
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Kinnear, C.; Glanzmann, B.; Banda, E.; Schlechter, N.; Durrheim, G.; Neethling, A.; Nel, E.; Schoeman, M.; Johnson, G.; van Helden, P. D.; Hoal, E. G.; Esser, M.; Urban, M.; and Möller, M. Exome sequencing identifies a novel TTC37 mutation in the first reported case of Trichohepatoenteric syndrome (THE-S) in South Africa. BMC medical genetics, 18(1): 26. March 2017. 00000
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Uren, C.; Henn, B. M.; Franke, A.; Wittig, M.; van Helden, P. D.; Hoal, E. G.; and Möller, M. A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility. PloS One, 12(4): e0174738. 2017. 00000
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le Roex, N.; Jolles, A.; Beechler, B.; van Helden, P.; and Hoal, E. Toll-like receptor (TLR) diversity influences mycobacterial growth in African buffalo. Tuberculosis (Edinburgh, Scotland), 104: 87–94. May 2017. 00000
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Shah, J. A.; Musvosvi, M.; Shey, M.; Horne, D. J.; Wells, R. D.; Peterson, G. J.; Cox, J. S.; Daya, M.; Hoal, E. G.; Lin, L.; Gottardo, R.; Hanekom, W. A.; Scriba, T. J.; Hatherill, M.; and Hawn, T. R. A Functional TOLLIP Variant is Associated with BCG-Specific Immune Responses and Tuberculosis. American Journal of Respiratory and Critical Care Medicine. May 2017. 00000
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van der Merwe, C.; van Dyk, H. C.; Engelbrecht, L.; van der Westhuizen, F. H.; Kinnear, C.; Loos, B.; and Bardien, S. Curcumin Rescues a PINK1 Knock Down SH-SY5Y Cellular Model of Parkinson's Disease from Mitochondrial Dysfunction and Cell Death. Molecular Neurobiology, 54(4): 2752–2762. May 2017. 00006
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Lumkwana, D.; du Toit, A.; Kinnear, C.; and Loos, B. Autophagic flux control in neurodegeneration: Progress and precision targeting-Where do we stand?. Progress in Neurobiology. April 2017. 00001
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  2016 (8)
Lombard, Z.; Baine, F.; Krause, A.; Lochan, A.; Macualay, S.; Spencer, C.; Aldous, C.; De Vries, J.; Fieggen, K.; Henderson, B.; Hoal, E.; Kinnear, C.; Kinsley, N.; September, A.; Urban, M.; Soodyall, H.; Pepper, M.; and Ramsay, M. Implications of direct-to-consumer whole-exome sequencing in South Africa. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde, 106(2): 139–140. January 2016. 00001
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Mouton, J. M.; van der Merwe, L.; Goosen, A.; Revera, M.; Brink, P. A.; Moolman-Smook, J. C.; and Kinnear, C. MYBPH acts as modifier of cardiac hypertrophy in hypertrophic cardiomyopathy (HCM) patients. Human Genetics, 135(5): 477–483. May 2016. 00001
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Haylett, W.; Swart, C.; van der Westhuizen, F.; van Dyk, H.; van der Merwe, L.; van der Merwe, C.; Loos, B.; Carr, J.; Kinnear, C.; and Bardien, S. Altered Mitochondrial Respiration and Other Features of Mitochondrial Function in Parkin-Mutant Fibroblasts from Parkinson's Disease Patients. Parkinson's Disease, 2016: 1819209. 2016. 00002
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Glanzmann, B.; Herbst, H.; Kinnear, C. J.; Möller, M.; Gamieldien, J.; and Bardien, S. A new tool for prioritization of sequence variants from whole exome sequencing data. Source Code for Biology and Medicine, 11: 10. 2016. 00000
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Jabot-Hanin, F.; Cobat, A.; Feinberg, J.; Grange, G.; Remus, N.; Poirier, C.; Boland-Auge, A.; Besse, C.; Bustamante, J.; Boisson-Dupuis, S.; Casanova, J.; Schurr, E.; Alcaïs, A.; Hoal, E. G.; Delacourt, C.; and Abel, L. Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations. The Journal of Infectious Diseases, 213(7): 1173–1179. April 2016. 00002
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Bowker, N.; Salie, M.; Schurz, H.; van Helden, P. D.; Kinnear, C. J.; Hoal, E. G.; and Möller, M. Polymorphisms in the Pattern Recognition Receptor Mincle Gene (CLEC4E) and Association with Tuberculosis. Lung, 194(5): 763–767. October 2016. 00001
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Uren, C.; Kim, M.; Martin, A. R.; Bobo, D.; Gignoux, C. R.; van Helden, P. D.; Möller, M.; Hoal, E. G.; and Henn, B. M. Fine-Scale Human Population Structure in Southern Africa Reflects Ecogeographic Boundaries. Genetics, 204(1): 303–314. September 2016. 00003
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Glanzmann, B.; Möller, M.; le Roex, N.; Tromp, G.; Hoal, E. G.; and van Helden, P. D. The complete genome sequence of the African buffalo (Syncerus caffer). BMC genomics, 17(1): 1001. December 2016. 00000
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  2015 (9)
Uys, P.; Brand, H.; Warren, R.; van der Spuy, G.; Hoal, E. G.; and van Helden, P. D. The Risk of Tuberculosis Reinfection Soon after Cure of a First Disease Episode Is Extremely High in a Hyperendemic Community. PloS One, 10(12): e0144487. 2015. 00001
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Schurz, H.; Daya, M.; Möller, M.; Hoal, E. G.; and Salie, M. TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis. PloS One, 10(10): e0139711. 2015. 00000
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Salie, M.; Daya, M.; Möller, M.; and Hoal, E. G. Activating KIRs alter susceptibility to pulmonary tuberculosis in a South African population. Tuberculosis (Edinburgh, Scotland). October 2015. 00000
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Mouton, J.; Loos, B.; Moolman-Smook, J. C.; and Kinnear, C. J. Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction. Experimental Cell Research, 331(2): 338–351. February 2015. 00000
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Mouton, J. M.; Pellizzon, A. S.; Goosen, A.; Kinnear, C. J.; Herbst, P. G.; Brink, P. A.; and Moolman-Smook, J. C. Diagnostic disparity and identification of two TNNI3 gene mutations, one novel and one arising de novo, in South African patients with restrictive cardiomyopathy and focal ventricular hypertrophy. Cardiovascular Journal of Africa, 26(2): 63–69. April 2015. 00000
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Salie, M.; Daya, M.; Lucas, L. A.; Warren, R. M.; van der Spuy, G. D.; van Helden, P. D.; Hoal, E. G.; and Möller, M. Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 34: 221–229. August 2015.
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Daya, M.; van der Merwe, L.; van Helden, P. D.; Möller, M.; and Hoal, E. G. Investigating the Role of Gene-Gene Interactions in TB Susceptibility. PloS One, 10(4): e0123970. 2015. 00000
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le Roex, N.; Cooper, D.; van Helden, P. D.; Hoal, E. G.; and Jolles, A. E. Disease Control in Wildlife: Evaluating a Test and Cull Programme for Bovine Tuberculosis in African Buffalo. Transboundary and Emerging Diseases. January 2015. 00000
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le Roex, N.; Berrington, C. M.; Hoal, E. G.; and van Helden, P. D. Selective breeding: The future of TB management in African buffalo?. Acta Tropica, 149: 38–44. May 2015. 00000
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  2014 (5)
Daya, M.; van der Merwe, L.; Gignoux, C. R.; van Helden, P. D.; Möller, M.; and Hoal, E. G. Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population. BMC genomics, 15: 1021. 2014. 00000
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Salie, M.; van der Merwe, L.; Möller, M.; Daya, M.; van der Spuy, G. D.; van Helden, P. D.; Martin, M. P.; Gao, X.; Warren, R. M.; Carrington, M.; and Hoal, E. G. Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease. The Journal of Infectious Diseases, 209(2): 216–223. January 2014. 00006
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Chimusa, E. R.; Zaitlen, N.; Daya, M.; Möller, M.; van Helden, P. D.; Mulder, N. J.; Price, A. L.; and Hoal, E. G. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. Human Molecular Genetics, 23(3): 796–809. February 2014. 00020
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Kidd, J. M.; Sharpton, T. J.; Bobo, D.; Norman, P. J.; Martin, A. R.; Carpenter, M. L.; Sikora, M.; Gignoux, C. R.; Nemat-Gorgani, N.; Adams, A.; Guadalupe, M.; Guo, X.; Feng, Q.; Li, Y.; Liu, X.; Parham, P.; Hoal, E. G.; Feldman, M. W.; Pollard, K. S.; Wall, J. D.; Bustamante, C. D.; and Henn, B. M. Exome capture from saliva produces high quality genomic and metagenomic data. BMC genomics, 15: 262. 2014. 00004
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Daya, M.; van der Merwe, L.; van Helden, P. D.; Möller, M.; and Hoal, E. G. The role of ancestry in TB susceptibility of an admixed South African population. Tuberculosis (Edinburgh, Scotland), 94(4): 413–420. July 2014. 00002
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  2013 (8)
Daya, M.; van der Merwe, L.; Galal, U.; Möller, M.; Salie, M.; Chimusa, E. R.; Galanter, J. M.; van Helden, P. D.; Henn, B. M.; Gignoux, C. R.; and Hoal, E. A panel of ancestry informative markers for the complex five-way admixed South African coloured population. PloS One, 8(12): e82224. 2013.
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van Helden, P. D.; and Hoal, E. G. A new TB vaccine: fact or fiction?. Comparative Immunology, Microbiology and Infectious Diseases, 36(3): 287–294. May 2013. 00004
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Hemmings, S. M. J.; Martin, L. I.; Klopper, M.; van der Merwe, L.; Aitken, L.; de Wit, E.; Black, G. F.; Hoal, E. G.; Walzl, G.; and Seedat, S. BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: a preliminary investigation in a South African population. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 40: 273–280. January 2013. 00012