Keyword: infant
2017 (6)
Teduglutide: A Review in Short Bowel Syndrome. Kim E.S. & Keam S.J. 2017.
![Teduglutide: A Review in Short Bowel Syndrome [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper abstract bibtex
Paper abstract bibtex Subcutaneous teduglutide (Revestive), a glucagon-like peptide-2 analogue that increases intestinal absorption, is approved in the EU for the treatment of short bowel syndrome (SBS) in patients aged \textgreater1 year who are stable following a period of postsurgical intestinal adaptation. In a phase III trial in adults with SBS intestinal failure (IF) dependent on parenteral support (PS), a significantly greater proportion of teduglutide 0.05 mg/kg/day than placebo recipients achieved a \textgreater20% reduction in weekly PS volume from baseline to week 20 and maintained it to week 24. The proportion of patients who had a reduction in one or more days on PS was also significant with teduglutide compared with placebo. Improved intestinal absorption and reduced PS requirements were generally maintained in the longer term. Results from a phase III trial in paediatric patients with SBS-IF dependent on PS were consistent with those in adults. Adverse events were mostly of mild to moderate severity and generally consistent with the underlying condition or known mechanism of the drug (e.g. central line-related issues, gastrointestinal events). Teduglutide is therefore a useful treatment option in children (aged \textgreater1 year), adolescents and adults with SBS. Copyright © 2017, Springer International Publishing Switzerland. All Right Reserved.
@misc{kim_e.s._teduglutide:_2017,
title = {Teduglutide: {A} {Review} in {Short} {Bowel} {Syndrome}},
url = {http://rd.springer.com/journal/40265},
abstract = {Subcutaneous teduglutide (Revestive), a glucagon-like peptide-2 analogue that increases intestinal absorption, is approved in the EU for the treatment of short bowel syndrome (SBS) in patients aged {\textgreater}1 year who are stable following a period of postsurgical intestinal adaptation. In a phase III trial in adults with SBS intestinal failure (IF) dependent on parenteral support (PS), a significantly greater proportion of teduglutide 0.05 mg/kg/day than placebo recipients achieved a {\textgreater}20\% reduction in weekly PS volume from baseline to week 20 and maintained it to week 24. The proportion of patients who had a reduction in one or more days on PS was also significant with teduglutide compared with placebo. Improved intestinal absorption and reduced PS requirements were generally maintained in the longer term. Results from a phase III trial in paediatric patients with SBS-IF dependent on PS were consistent with those in adults. Adverse events were mostly of mild to moderate severity and generally consistent with the underlying condition or known mechanism of the drug (e.g. central line-related issues, gastrointestinal events). Teduglutide is therefore a useful treatment option in children (aged {\textgreater}1 year), adolescents and adults with SBS. Copyright © 2017, Springer International Publishing Switzerland. All Right Reserved.},
journal = {Drugs},
author = {{Kim E.S.} and {Keam S.J.}},
year = {2017},
keywords = {*short bowel syndrome, *short bowel syndrome/dt [Drug Therapy], *short bowel syndrome/th [Therapy], *teduglutide, *teduglutide/ae [Adverse Drug Reaction], *teduglutide/dt [Drug Therapy], *teduglutide/pd [Pharmacology], *teduglutide/pk [Pharmacokinetics], *teduglutide/sc [Subcutaneous Drug Administration], Child, Parenteral nutrition, abdominal distension/si [Side Effect], acute cholecystitis/si [Side Effect], adolescent, adult, adverse drug reaction, article, catheter infection/co [Complication], central venous catheter, central venous catheter/am [Adverse Device Effect], clinical study, clinical trial, controlled clinical trial, controlled study, decreased appetite/si [Side Effect], disease severity, drug efficacy, drug therapy, drug tolerability, gastrointestinal dysplasia/si [Side Effect], gastrointestinal polyposis/si [Side Effect], gastrointestinal symptom/si [Side Effect], gastrointestinal tract, gastrointestinal tumor/si [Side Effect], human, infant, influenza/si [Side Effect], injection site erythema/si [Side Effect], intestinal failure, intestine absorption, intestine polyp/si [Side Effect], intestine stenosis/si [Side Effect], multicenter study (topic), nonhuman, peripheral edema/si [Side Effect], pharmacodynamic parameters, phase 3 clinical trial, phase 3 clinical trial (topic), placebo, recipient, rectum polyp/si [Side Effect], rhinopharyngitis/si [Side Effect], sepsis/co [Complication], short bowel syndrome/dt [Drug Therapy], side effect, stomach adenoma/si [Side Effect], systematic review, upper abdominal pain/si [Side Effect]}
}Nitric oxide for respiratory failure in infants born at or near term. Barrington K.J., Finer N., Pennaforte T., & Altit G. 2017.
Paper abstract bibtex
Paper abstract bibtex Background: Nitric oxide (NO) is a major endogenous regulator of vascular tone. Inhaled nitric oxide (iNO) gas has been investigated as treatment for persistent pulmonary hypertension of the newborn. Objectives: To determine whether treatment of hypoxaemic term and near-term newborn infants with iNO improves oxygenation and reduces rate of death and use of extracorporeal membrane oxygenation (ECMO), or affects long-term neurodevelopmental outcomes. Search methods: We used the standard search strategy of the Cochrane Neonatal Review Group to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE via PubMed (1966 to January 2016), Embase (1980 to January 2016) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 to January 2016). We searched clinical trials databases, conference proceedings and reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials. We contacted the principal investigators of studies published as abstracts to ascertain the necessary information. Selection criteria: Randomised studies of iNO in term and near-term infants with hypoxic respiratory failure, with clinically relevant outcomes, including death, use of ECMO and oxygenation. Data collection and analysis: We analysed trial reports to assess methodological quality using the criteria of the Cochrane Neonatal Review Group. We tabulated mortality, oxygenation, short-term clinical outcomes (particularly use of ECMO) and long-term developmental outcomes. Statistics: For categorical outcomes, we calculated typical estimates for risk ratios and risk differences. For continuous variables, we calculated typical estimates for weighted mean differences. We used 95% confidence intervals and assumed a fixed-effect model for meta-analysis. Main results: We found 17 eligible randomised controlled studies that included term and near-term infants with hypoxia. Ten trials compared iNO versus control (placebo or standard care without iNO) in infants with moderate or severe severity of illness scores (Ninos 1996; Roberts 1996; Wessel 1996; Davidson 1997; Ninos 1997; Mercier 1998; Christou 2000; Clark 2000; INNOVO 2007; Liu 2008). Mercier 1998 compared iNO versus control but allowed back-up treatment with iNO for infants who continued to satisfy the same criteria for severity of illness after two hours. This trial enrolled both preterm and term infants but reported most results separately for the two groups. Ninos 1997 studied only infants with congenital diaphragmatic hernia. One trial compared iNO versus high-frequency ventilation (Kinsella 1997). Six trials enrolled infants with moderate severity of illness scores (oxygenation index (OI) or alveolar-arterial oxygen difference (A-aDO2)) and randomised them to immediate iNO treatment or iNO treatment only after deterioration to more severe criteria (Barefield 1996; Day 1996; Sadiq 1998; Cornfield 1999; Konduri 2004; Gonzalez 2010). Inhaled nitric oxide appears to have improved outcomes in hypoxaemic term and near-term infants by reducing the incidence of the combined endpoint of death or use of ECMO (high-quality evidence). This reduction was due to a reduction in use of ECMO (with number needed to treat for an additional beneficial outcome (NNTB) of 5.3); mortality was not affected. Oxygenation was improved in approximately 50% of infants receiving iNO. The OI was decreased by a (weighted) mean of 15.1 within 30 to 60 minutes after the start of therapy, and partial pressure of arterial oxygen (PaO2) was increased by a mean of 53 mmHg. Whether infants had clear echocardiographic evidence of persistent pulmonary hypertension of the newborn (PPHN) did not appear to affect response to iNO. Outcomes of infants with diaphragmatic hernia were not improved; outcomes were slightly, but not significantly, worse with iNO (moderate-quality evidence). Infants who received iNO at less severe criteria did not have better clinical outcomes than those who were enrolled but received treatment only if their condition deteriorated. Fewer of the babies who received iNO early satisfied late treatment criteria, showing that earlier iNO reduced progression of the disease but did not further decrease mortality nor the need for ECMO (moderate-quality evidence). Incidence of disability, incidence of deafness and infant development scores were all similar between tested survivors who received iNO and those who did not. Authors' conclusions: Inhaled nitric oxide is effective at an initial concentration of 20 ppm for term and near-term infants with hypoxic respiratory failure who do not have a diaphragmatic hernia. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
@misc{barrington_k.j._nitric_2017,
title = {Nitric oxide for respiratory failure in infants born at or near term},
url = {http://as.wiley.com/WileyCDA/Brand/id-6.html},
abstract = {Background: Nitric oxide (NO) is a major endogenous regulator of vascular tone. Inhaled nitric oxide (iNO) gas has been investigated as treatment for persistent pulmonary hypertension of the newborn. Objectives: To determine whether treatment of hypoxaemic term and near-term newborn infants with iNO improves oxygenation and reduces rate of death and use of extracorporeal membrane oxygenation (ECMO), or affects long-term neurodevelopmental outcomes. Search methods: We used the standard search strategy of the Cochrane Neonatal Review Group to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE via PubMed (1966 to January 2016), Embase (1980 to January 2016) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 to January 2016). We searched clinical trials databases, conference proceedings and reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials. We contacted the principal investigators of studies published as abstracts to ascertain the necessary information. Selection criteria: Randomised studies of iNO in term and near-term infants with hypoxic respiratory failure, with clinically relevant outcomes, including death, use of ECMO and oxygenation. Data collection and analysis: We analysed trial reports to assess methodological quality using the criteria of the Cochrane Neonatal Review Group. We tabulated mortality, oxygenation, short-term clinical outcomes (particularly use of ECMO) and long-term developmental outcomes. Statistics: For categorical outcomes, we calculated typical estimates for risk ratios and risk differences. For continuous variables, we calculated typical estimates for weighted mean differences. We used 95\% confidence intervals and assumed a fixed-effect model for meta-analysis. Main results: We found 17 eligible randomised controlled studies that included term and near-term infants with hypoxia. Ten trials compared iNO versus control (placebo or standard care without iNO) in infants with moderate or severe severity of illness scores (Ninos 1996; Roberts 1996; Wessel 1996; Davidson 1997; Ninos 1997; Mercier 1998; Christou 2000; Clark 2000; INNOVO 2007; Liu 2008). Mercier 1998 compared iNO versus control but allowed back-up treatment with iNO for infants who continued to satisfy the same criteria for severity of illness after two hours. This trial enrolled both preterm and term infants but reported most results separately for the two groups. Ninos 1997 studied only infants with congenital diaphragmatic hernia. One trial compared iNO versus high-frequency ventilation (Kinsella 1997). Six trials enrolled infants with moderate severity of illness scores (oxygenation index (OI) or alveolar-arterial oxygen difference (A-aDO2)) and randomised them to immediate iNO treatment or iNO treatment only after deterioration to more severe criteria (Barefield 1996; Day 1996; Sadiq 1998; Cornfield 1999; Konduri 2004; Gonzalez 2010). Inhaled nitric oxide appears to have improved outcomes in hypoxaemic term and near-term infants by reducing the incidence of the combined endpoint of death or use of ECMO (high-quality evidence). This reduction was due to a reduction in use of ECMO (with number needed to treat for an additional beneficial outcome (NNTB) of 5.3); mortality was not affected. Oxygenation was improved in approximately 50\% of infants receiving iNO. The OI was decreased by a (weighted) mean of 15.1 within 30 to 60 minutes after the start of therapy, and partial pressure of arterial oxygen (PaO2) was increased by a mean of 53 mmHg. Whether infants had clear echocardiographic evidence of persistent pulmonary hypertension of the newborn (PPHN) did not appear to affect response to iNO. Outcomes of infants with diaphragmatic hernia were not improved; outcomes were slightly, but not significantly, worse with iNO (moderate-quality evidence). Infants who received iNO at less severe criteria did not have better clinical outcomes than those who were enrolled but received treatment only if their condition deteriorated. Fewer of the babies who received iNO early satisfied late treatment criteria, showing that earlier iNO reduced progression of the disease but did not further decrease mortality nor the need for ECMO (moderate-quality evidence). Incidence of disability, incidence of deafness and infant development scores were all similar between tested survivors who received iNO and those who did not. Authors' conclusions: Inhaled nitric oxide is effective at an initial concentration of 20 ppm for term and near-term infants with hypoxic respiratory failure who do not have a diaphragmatic hernia. Copyright © 2017 The Cochrane Collaboration. Published by John Wiley \& Sons, Ltd.},
journal = {Cochrane Database of Systematic Reviews},
author = {{Barrington K.J.} and {Finer N.} and {Pennaforte T.} and {Altit G.}},
year = {2017},
keywords = {*childbirth, *nitric oxide, *respiratory failure, Cinahl, Cochrane Library, Embase, Medline, arterial oxygen tension, attributable risk, cerebral palsy, child development, clinical outcome, confidence interval, congenital diaphragm hernia, controlled clinical trial, controlled study, death, deterioration, disability, disease severity, exposure, extracorporeal oxygenation, hearing impairment, high frequency ventilation, human, hypoxia, infant, infant mortality, information processing, lung vascular resistance, meta analysis, mortality, newborn, oxygen, oxygenation, partial pressure, persistent pulmonary hypertension, placebo, priority journal, randomized controlled trial, review, sensitivity analysis, statistics, survivor, systematic review, tissue oxygenation}
}Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: A randomized trial. Totonchi Z., Rezvani H., Ghorbanloo M., Yazdanian F., Mahdavi M., Babaali N., Salajegheh S., & Chitsazan M. 2017.
![Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: A randomized trial [pdf]](https://bibbase.org/img/filetypes/pdf.svg "pdf")
Paper abstract bibtex
Paper abstract bibtex Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.
@misc{totonchi_z._effect_2017,
title = {Effect of dexmedetomidine infusion on hemodynamics and stress responses in pediatric cardiac surgery: {A} randomized trial},
url = {http://cardiovascmed.com/72535.pdf},
abstract = {Background: Infants and children compared with adults have intensified stress responses that lead to increased morbidity and mortality. Stress control reduces the incidence of complications and improves recovery. In clinical and experimental studies, dexmedetomidine reduces the inflammatory and neuroendocrine responses. Objectives: This prospective randomized double-blinded clinical trial was conducted to assess the role of dexmedetomidine in reducing stress responses. Materials and Methods: According to convenient sampling method, 40 patients in two groups (case under treatment with dexmedetomidine and control, each including 20 patients) were selected from whom admitted for open heart surgery. Anesthesia was induced and maintained by fentanyl and midazolam. After central venous and arterial catheter insertion, patients were randomly allocated into one of two equal groups (n = 20 each). In the dexmedetomidine group, patients received an initial loading dose (0.5 micro g/kg) during 10 minutes immediately followed by a continuous infusion of 0.5 micro g/kg. In the control group, normal saline solution with similar volume was infused. Results: Changes in heart rate, systolic and diastolic blood pressures and central venous pressure before administration of dexmedetomidine, in 10, 20 and 30 minutes after the operation, after skin incision, after sternotomy, after separation from the pump and at the end of procedure showed no significant difference between the two groups (P = 0.860, 0.067, 0.888 and 0.482, respectively). Changes in lactate, interleukin 6, tumor necrosis factor, C-reactive protein concentrations before administration of dexmedetomidine, after separation of pump and 24 hours after intensive care unit entrance showed no significant difference between the two groups (P = 0.525, 0.767, 0.868 and 0.840, respectively). Conclusions: According to our findings, using dexmedetomidine as an adjuvant anesthetic medication with initial loading dose of 0.5 micro g/kg and maintenance dose of 0.5 micro g/kg in pediatric heart surgeries is a safe choice. However, further studies are needed to clarify the role of dexmedetomidine to reduce stress responses. Copyright © 2016 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences.},
journal = {Research in Cardiovascular Medicine},
author = {{Totonchi Z.} and {Rezvani H.} and {Ghorbanloo M.} and {Yazdanian F.} and {Mahdavi M.} and {Babaali N.} and {Salajegheh S.} and {Chitsazan M.}},
year = {2017},
keywords = {*chemical stress, *dexmedetomidine, *dexmedetomidine/ct [Clinical Trial], *diastolic blood pressure, *heart surgery, *hemodynamics, *infusion, *open heart surgery, *stress, Anesthesia, C reactive protein, C reactive protein/ec [Endogenous Compound], Child, adjuvant, artery catheter, article, cardiopulmonary bypass, central venous catheter, central venous pressure, clinical article, clinical trial, continuous infusion, control group, controlled clinical trial, controlled study, diastolic blood pressure, drug therapy, endogenous compound, female, fentanyl, heart rate, human, hypertension, hypotension, incidence, infant, inflammation, intensive care unit, interleukin 6, interleukin 6/ec [Endogenous Compound], lactate dehydrogenase/ec [Endogenous Compound], lactic acid, loading drug dose, lymphotoxin beta, maintenance drug dose, male, midazolam, normal human, preschool child, prospective study, randomized controlled trial, sampling, single blind procedure, skin incision, sodium chloride, sternotomy, systolic blood pressure, tumor necrosis factor/ec [Endogenous Compound]}
}Universal versus conditional three-day follow up visit for children with uncomplicated fever at the community level: Design of a cluster-randomized, community-based, non-inferiority trial in Tanganyika, Democratic Republic of Congo. van Boetzelaer E., Ho L.S., Gutman J.R., Steinhardt L.C., Wittcoff A., Barbera Y., Ngoy P., Harvey S.A., & Mullany L.C. 2017.
Paper abstract bibtex
Paper abstract bibtex Background: The current recommendation within integrated Community Case Management guidelines that all children presenting with uncomplicated fever and no danger signs be followed up after three days may not be necessary. Such fevers often resolve rapidly (usually within 48-96 h), and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aim to determine the non-inferiority of a conditional versus a universal follow-up visit for these children. Methods: We are conducting a cluster-randomized, community-based, non-inferiority trial enrolling \textasciitilde4300 children (ages 2-59 months) presenting to community health workers (CHWs) with uncomplicated fever in Tanganyika Province, Democratic Republic of the Congo. Clusters (n = 28) of CHWs are randomized to advise caretakers of such children to either 1) return for a follow-up visit on Day 3 following the initial consultation (Day 1), regardless of illness resolution (as per current guidelines) or 2) return for a follow-up visit on Day 3 only if the child's signs have not resolved. Enrolled children are followed up at Day 7 for a repeat assessment and recording of the primary outcome of the study, "failure", which is defined as having fever, diarrhea, pneumonia or decline of health status (e.g. hospitalization, presenting danger signs, or death). Discussion: The results of this trial will be interpreted in conjunction with a similarly designed trial currently ongoing in Ethiopia. If a follow-up visit conditional on continued illness is shown to be non-inferior to current guidelines stipulating universal follow-up, appropriate updating of such guidelines could reduce time and human resource pressures on both providers and caregivers throughout communities of sub-Saharan Africa and South Asia. Trial registration: This trial was registered at ClinicalTrials.gov (NCT02595827) on November 2nd, 2015 Copyright © 2017 The Author(s).
@misc{van_boetzelaer_e._universal_2017,
title = {Universal versus conditional three-day follow up visit for children with uncomplicated fever at the community level: {Design} of a cluster-randomized, community-based, non-inferiority trial in {Tanganyika}, {Democratic} {Republic} of {Congo}},
url = {http://www.biomedcentral.com/bmcpediatr/},
abstract = {Background: The current recommendation within integrated Community Case Management guidelines that all children presenting with uncomplicated fever and no danger signs be followed up after three days may not be necessary. Such fevers often resolve rapidly (usually within 48-96 h), and previous studies suggest that expectant home care for uncomplicated fever can be safely recommended. We aim to determine the non-inferiority of a conditional versus a universal follow-up visit for these children. Methods: We are conducting a cluster-randomized, community-based, non-inferiority trial enrolling {\textasciitilde}4300 children (ages 2-59 months) presenting to community health workers (CHWs) with uncomplicated fever in Tanganyika Province, Democratic Republic of the Congo. Clusters (n = 28) of CHWs are randomized to advise caretakers of such children to either 1) return for a follow-up visit on Day 3 following the initial consultation (Day 1), regardless of illness resolution (as per current guidelines) or 2) return for a follow-up visit on Day 3 only if the child's signs have not resolved. Enrolled children are followed up at Day 7 for a repeat assessment and recording of the primary outcome of the study, "failure", which is defined as having fever, diarrhea, pneumonia or decline of health status (e.g. hospitalization, presenting danger signs, or death). Discussion: The results of this trial will be interpreted in conjunction with a similarly designed trial currently ongoing in Ethiopia. If a follow-up visit conditional on continued illness is shown to be non-inferior to current guidelines stipulating universal follow-up, appropriate updating of such guidelines could reduce time and human resource pressures on both providers and caregivers throughout communities of sub-Saharan Africa and South Asia. Trial registration: This trial was registered at ClinicalTrials.gov (NCT02595827) on November 2nd, 2015 Copyright © 2017 The Author(s).},
journal = {BMC Pediatrics},
author = {{van Boetzelaer E.} and {Ho L.S.} and {Gutman J.R.} and {Steinhardt L.C.} and {Wittcoff A.} and {Barbera Y.} and {Ngoy P.} and {Harvey S.A.} and {Mullany L.C.}},
year = {2017},
keywords = {*Democratic Republic Congo, *Tanzania, *case management, *conditional three day follow up visit, *fever, *follow up, *health auxiliary, *pediatrics, *registration, *uncomplicated fever, *universal follow up visit, Child, Democratic Republic Congo, Ethiopia, South Asia, arm circumference, article, caregiver, clinical assessment, clinical protocol, clinical trial, consultation, controlled clinical trial, controlled study, death, diarrhea, feedback system, female, health auxiliary, health status, hospitalization, human, infant, information processing, major clinical study, male, midupper upper arm circumference, mortality, outcome assessment, patient monitoring, pneumonia, practice guideline, preschool child, quality control, randomization, randomized controlled trial, sample size, study design}
}Complication-related removal of totally implantable venous access port systems: Does the interval between placement and first use and the neutropenia-inducing potential of chemotherapy regimens influence their incidence? A four-year prospective study of 4045 patients. Kakkos, A., Bresson, L., Hudry, D., Cousin, S., Lervat, C., Bogart, E., Meurant, J. P., El Bedoui, S., Decanter, G., Hannebicque, K., Regis, C., Hamdani, A., Penel, N., Tresch-Bruneel, E., & Narducci, F. Eur J Surg Oncol, 43(4):689–695, 2017.
Paper doi abstract bibtex
Paper doi abstract bibtex BACKGROUND: Totally implantable venous access port systems are widely used in oncology, with frequent complications that sometimes necessitate device removal. The aim of this study is to investigate the impact of the time interval between port placement and initiation of chemotherapy and the neutropenia-inducing potential of the chemotherapy administered upon complication-related port removal. PATIENTS AND METHODS: Between January 2010 and December 2013, 4045 consecutive patients were included in this observational, single-center prospective study. The chemotherapy regimens were classified as having a low (\textbackslashtextbackslashtextless10%), intermediate (10-20%), or high (\textbackslashtextbackslashtextgreater20%) risk for inducing neutropenia. RESULTS: The overall removal rate due to complications was 7.2%. Among them, port-related infection (2.5%) and port expulsion (1%) were the most frequent. The interval between port insertion and its first use was shown to be a predictive factor for complication-related removal rates. A cut-off of 6 days was statistically significant (p = 0.008), as the removal rate for complications was 9.4% when this interval was 0-5 days and 5.7% when it was \textbackslashtextbackslashtextgreater/=6 days. Another factor associated with port complication rate was the neutropenia-inducing potential of the chemotherapy regimens used, with removal for complications involved in 5.5% of low-risk regimens versus 9.4% for the intermediate- and high-risk regimens (p = 0.003). CONCLUSION: An interval of 6 days between placement and first use of the port reduces the removal rate from complications. The intermediate- and high-risk for neutropenia chemotherapy regimens are related to higher port removal rates from complications than low-risk regimens.
@article{kakkos_complication-related_2017,
title = {Complication-related removal of totally implantable venous access port systems: {Does} the interval between placement and first use and the neutropenia-inducing potential of chemotherapy regimens influence their incidence? {A} four-year prospective study of 4045 patients},
volume = {43},
issn = {1532-2157 (Electronic) 0748-7983 (Linking)},
url = {http://www.ncbi.nlm.nih.gov/pubmed/27889197},
doi = {10.1016/j.ejso.2016.10.020},
abstract = {BACKGROUND: Totally implantable venous access port systems are widely used in oncology, with frequent complications that sometimes necessitate device removal. The aim of this study is to investigate the impact of the time interval between port placement and initiation of chemotherapy and the neutropenia-inducing potential of the chemotherapy administered upon complication-related port removal. PATIENTS AND METHODS: Between January 2010 and December 2013, 4045 consecutive patients were included in this observational, single-center prospective study. The chemotherapy regimens were classified as having a low ({\textbackslash}textbackslashtextless10\%), intermediate (10-20\%), or high ({\textbackslash}textbackslashtextgreater20\%) risk for inducing neutropenia. RESULTS: The overall removal rate due to complications was 7.2\%. Among them, port-related infection (2.5\%) and port expulsion (1\%) were the most frequent. The interval between port insertion and its first use was shown to be a predictive factor for complication-related removal rates. A cut-off of 6 days was statistically significant (p = 0.008), as the removal rate for complications was 9.4\% when this interval was 0-5 days and 5.7\% when it was {\textbackslash}textbackslashtextgreater/=6 days. Another factor associated with port complication rate was the neutropenia-inducing potential of the chemotherapy regimens used, with removal for complications involved in 5.5\% of low-risk regimens versus 9.4\% for the intermediate- and high-risk regimens (p = 0.003). CONCLUSION: An interval of 6 days between placement and first use of the port reduces the removal rate from complications. The intermediate- and high-risk for neutropenia chemotherapy regimens are related to higher port removal rates from complications than low-risk regimens.},
number = {4},
journal = {Eur J Surg Oncol},
author = {Kakkos, A. and Bresson, L. and Hudry, D. and Cousin, S. and Lervat, C. and Bogart, E. and Meurant, J. P. and El Bedoui, S. and Decanter, G. and Hannebicque, K. and Regis, C. and Hamdani, A. and Penel, N. and Tresch-Bruneel, E. and Narducci, F.},
year = {2017},
keywords = {*Vascular Access Devices, 80 and over, Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/*adverse effects, Catheter Obstruction/statistics \& numerical data, Catheter-Related Infections/*epidemiology, Child, Device Removal/*statistics \& numerical data, Equipment Failure/*statistics \& numerical data, Female, Foreign-Body Migration/*epidemiology, Hematoma/epidemiology, Humans, Incidence, Infant, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neoplasms/*drug therapy, Neutropenia/chemically induced, Postoperative Complications/*epidemiology, Preschool, Prospective Studies, Prosthesis Implantation, Thrombosis/epidemiology, Young Adult},
pages = {689--695},
}Effectiveness of airway clearance techniques in children hospitalized with acute bronchiolitis. Van Ginderdeuren F., Vandenplas Y., Deneyer M., Vanlaethem S., Buyl R., & Kerckhofs E. 2017.
Paper abstract bibtex
Paper abstract bibtex Objective: To evaluate the effectiveness of two airway clearance techniques (ACT's) in children \textless24 months hospitalized with mild to moderate bronchiolitis. Design: One hundred and three children were randomly allocated to receive one 20-min session daily, either assisted autogenic drainage (AAD), intrapulmonary percussive ventilation (IPV), or bouncing (B) (control group), ninety-three finished the study. Outcome measures: Mean time to recovery in days was our primary outcome measure. The impact of the treatment and the daily improvement was also assessed by a validated clinical and respiratory severity score (WANG score), heart rate (HR), and oxygen saturation (SaO2). Results: Mean time to recovery was 4.5 +/- 1.9 days for the control group, 3.6 +/- 1.4 days, P \textless 0.05 for the AAD group and 3.5 +/- 1.3 days, P = 0.03 for the IPV group. Wang scores improved significantly for both physiotherapy techniques compared to the control group. Conclusion: Both ACT's reduced significantly the length of hospital stay compared to no physiotherapy. Pediatr Pulmonol. 2017;52:225-231. © 2016 Wiley Periodicals, Inc. Copyright © 2016 Wiley Periodicals, Inc.
@misc{van_ginderdeuren_f._effectiveness_2017,
title = {Effectiveness of airway clearance techniques in children hospitalized with acute bronchiolitis},
url = {http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0496},
abstract = {Objective: To evaluate the effectiveness of two airway clearance techniques (ACT's) in children {\textless}24 months hospitalized with mild to moderate bronchiolitis. Design: One hundred and three children were randomly allocated to receive one 20-min session daily, either assisted autogenic drainage (AAD), intrapulmonary percussive ventilation (IPV), or bouncing (B) (control group), ninety-three finished the study. Outcome measures: Mean time to recovery in days was our primary outcome measure. The impact of the treatment and the daily improvement was also assessed by a validated clinical and respiratory severity score (WANG score), heart rate (HR), and oxygen saturation (SaO2). Results: Mean time to recovery was 4.5 +/- 1.9 days for the control group, 3.6 +/- 1.4 days, P {\textless} 0.05 for the AAD group and 3.5 +/- 1.3 days, P = 0.03 for the IPV group. Wang scores improved significantly for both physiotherapy techniques compared to the control group. Conclusion: Both ACT's reduced significantly the length of hospital stay compared to no physiotherapy. Pediatr Pulmonol. 2017;52:225-231. © 2016 Wiley Periodicals, Inc. Copyright © 2016 Wiley Periodicals, Inc.},
journal = {Pediatric Pulmonology},
author = {{Van Ginderdeuren F.} and {Vandenplas Y.} and {Deneyer M.} and {Vanlaethem S.} and {Buyl R.} and {Kerckhofs E.}},
year = {2017},
keywords = {*assisted autogenic drainage, *breathing exercise, *bronchiolitis, *bronchiolitis/th [Therapy], *hospital patient, *intrapulmonary percussive ventilation, *lung clearance, Child, WANG score, arterial oxygen saturation, article, artificial ventilation, clinical effectiveness, control group, controlled clinical trial, controlled study, disease severity, disease severity assessment, female, heart rate, hospitalization, human, infant, length of stay, major clinical study, male, outcome assessment, oxygen saturation, randomized controlled trial}
}2016 (5)
Vitamin d deficiency as risk factor for severity of acute lower respiratory tract infections. Cazan C., Neamtu M.L., Neamtu B.M., Bodrug N., & Istrate V. 2016.
abstract bibtex
abstract bibtex
Background and aims Vitamin D deficiency is highly prevalent and it is declared a public health problem for children worldwide. The aim of this study was to investigate the potential relationship between vitamin D deficiency and severity of lower respiratory tract infections. Methods Children aged six to eighteen months, admitted in Pediatric Clinic from September 2015 to March 2016 for lower respiratory tract infection were recruited for the study. Criteria for hospitalization include low oxygen saturation (\textless90-92%), moderate to severe respiratory distress, deshydration and presence of apnea. We measured plasma 25- hydroxyvitamin D concentrations in a random sample of 53 patients. Baseline vitamin D status was classified as deficient level less than 20 ng/mL, insufficient (20-30 ng/mL) or sufficient \textgreater30 ng/mL. Results The prevalence of vitamin D deficiency was 21% and 48% of patients were vitamin D insufficient. Mean +/- SD serum levels of vitamin D were significantly higher (p\textless 0.05) in patients with moderate disease (26.3+/-5.2 ng/mL) compared with those with severe disease (14.5+/-5.9 ng/ mL). Vitamin D deficiency was associated with increased risk of severe bronchiolitis and lower respiratory tract infection in the first year of life. Vitamin D deficiency was associated with a longer length of stay. Vitamin D insufficiency was most commonly diagnosed in the winter / spring season (44%). Conclusions Vitamin D deficiency is related to increased risk and greater severity of respiratory infections. Current recommendations for vitamin D supplementation should be followed especially in infants at high risk.
@misc{cazan_c._vitamin_2016,
title = {Vitamin d deficiency as risk factor for severity of acute lower respiratory tract infections},
abstract = {Background and aims Vitamin D deficiency is highly prevalent and it is declared a public health problem for children worldwide. The aim of this study was to investigate the potential relationship between vitamin D deficiency and severity of lower respiratory tract infections. Methods Children aged six to eighteen months, admitted in Pediatric Clinic from September 2015 to March 2016 for lower respiratory tract infection were recruited for the study. Criteria for hospitalization include low oxygen saturation ({\textless}90-92\%), moderate to severe respiratory distress, deshydration and presence of apnea. We measured plasma 25- hydroxyvitamin D concentrations in a random sample of 53 patients. Baseline vitamin D status was classified as deficient level less than 20 ng/mL, insufficient (20-30 ng/mL) or sufficient {\textgreater}30 ng/mL. Results The prevalence of vitamin D deficiency was 21\% and 48\% of patients were vitamin D insufficient. Mean +/- SD serum levels of vitamin D were significantly higher (p{\textless} 0.05) in patients with moderate disease (26.3+/-5.2 ng/mL) compared with those with severe disease (14.5+/-5.9 ng/ mL). Vitamin D deficiency was associated with increased risk of severe bronchiolitis and lower respiratory tract infection in the first year of life. Vitamin D deficiency was associated with a longer length of stay. Vitamin D insufficiency was most commonly diagnosed in the winter / spring season (44\%). Conclusions Vitamin D deficiency is related to increased risk and greater severity of respiratory infections. Current recommendations for vitamin D supplementation should be followed especially in infants at high risk.},
journal = {European Journal of Pediatrics},
author = {{Cazan C.} and {Neamtu M.L.} and {Neamtu B.M.} and {Bodrug N.} and {Istrate V.}},
year = {2016},
keywords = {*lower respiratory tract infection, *risk factor, *vitamin D deficiency, 25 hydroxyvitamin D, Child, apnea monitoring, bronchiolitis, clinical trial, controlled study, dehydration, diagnosis, hospitalization, human, human tissue, infant, length of stay, major clinical study, oxygen saturation, pediatric hospital, plasma, prevalence, random sample, respiratory distress, spring, winter}
}Early high-frequency oscillatory ventilation in pediatric acute respiratory failure: A propensity score analysis. Bateman S.T., Borasino S., Asaro L.A., Cheifetz I.M., Diane S., Wypij D., & Curley M.A.Q. 2016.
Paper abstract bibtex
Paper abstract bibtex Rationale: The use of high-frequency oscillatory ventilation (HFOV) for acute respiratory failure in children is prevalent despite the lack of efficacy data. Objectives: To compare the outcomes of patients with acute respiratory failure managed with HFOV within 24-48 hours of endotracheal intubation with those receiving conventional mechanical ventilation (CMV) and/or late HFOV. Methods: This is a secondary analysis of data from the RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) study, a prospective cluster randomized clinical trial conducted between 2009 and 2013 in 31 U.S. pediatric intensive care units. Propensity score analysis, including degree of hypoxia in the model, compared the duration of mechanical ventilation and mortality of patients treated with early HFOV matched with those treated with CMV/late HFOV. Measurements and Main Results: Among 2,449 subjects enrolled in RESTORE, 353 patients (14%) were ever supported on HFOV, of which 210 (59%) had HFOV initiated within 24-48 hours of intubation. The propensity score model predicting the probability of receiving early HFOV included 1,064 patients (181 early HFOV vs. 883 CMV/late HFOV) with significant hypoxia (oxygenation index \textgreater8). The degree of hypoxia was the most significant contributor to the propensity score model. After adjusting for risk category, early HFOV use was associated with a longer duration of mechanical ventilation (hazard ratio, 0.75; 95% confidence interval, 0.64-0.89; P = 0.001) but not with mortality (odds ratio, 1.28; 95% confidence interval, 0.92-1.79; P = 0.15) compared with CMV/late HFOV. Conclusions: In adjusted models including important oxygenation variables, early HFOV was associated with a longer duration of mechanical ventilation. These analyses make supporting the current approach to HFOV less convincing.
@misc{bateman_s.t._early_2016,
title = {Early high-frequency oscillatory ventilation in pediatric acute respiratory failure: {A} propensity score analysis},
url = {http://www.atsjournals.org/doi/pdf/10.1164/rccm.201507-1381OC},
abstract = {Rationale: The use of high-frequency oscillatory ventilation (HFOV) for acute respiratory failure in children is prevalent despite the lack of efficacy data. Objectives: To compare the outcomes of patients with acute respiratory failure managed with HFOV within 24-48 hours of endotracheal intubation with those receiving conventional mechanical ventilation (CMV) and/or late HFOV. Methods: This is a secondary analysis of data from the RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) study, a prospective cluster randomized clinical trial conducted between 2009 and 2013 in 31 U.S. pediatric intensive care units. Propensity score analysis, including degree of hypoxia in the model, compared the duration of mechanical ventilation and mortality of patients treated with early HFOV matched with those treated with CMV/late HFOV. Measurements and Main Results: Among 2,449 subjects enrolled in RESTORE, 353 patients (14\%) were ever supported on HFOV, of which 210 (59\%) had HFOV initiated within 24-48 hours of intubation. The propensity score model predicting the probability of receiving early HFOV included 1,064 patients (181 early HFOV vs. 883 CMV/late HFOV) with significant hypoxia (oxygenation index {\textgreater}8). The degree of hypoxia was the most significant contributor to the propensity score model. After adjusting for risk category, early HFOV use was associated with a longer duration of mechanical ventilation (hazard ratio, 0.75; 95\% confidence interval, 0.64-0.89; P = 0.001) but not with mortality (odds ratio, 1.28; 95\% confidence interval, 0.92-1.79; P = 0.15) compared with CMV/late HFOV. Conclusions: In adjusted models including important oxygenation variables, early HFOV was associated with a longer duration of mechanical ventilation. These analyses make supporting the current approach to HFOV less convincing.},
journal = {American Journal of Respiratory and Critical Care Medicine},
author = {{Bateman S.T.} and {Borasino S.} and {Asaro L.A.} and {Cheifetz I.M.} and {Diane S.} and {Wypij D.} and {Curley M.A.Q.}},
year = {2016},
keywords = {*acute respiratory failure, *acute respiratory failure/th [Therapy], *adult respiratory distress syndrome, *childhood disease/th [Therapy], *early intervention, *high frequency ventilation, *oxygenation, *propensity score, Child, adolescent, article, clinical trial, confidence interval, controlled clinical trial, controlled study, endotracheal intubation, female, hazard ratio, human, hypoxia, infant, intermethod comparison, intubation, major clinical study, male, mortality, newborn, odds ratio, outcome assessment, pediatric intensive care unit, priority journal, probability, propensity score, randomized controlled trial, randomized controlled trial (topic), secondary analysis, sedation, statistical model, titrimetry, treatment duration}
}Smoflipid for prevention of parenteral nutrition associated cholestasis in elbwinfants. Repa A., Binder C., Thanhaeuser M., Kreissl A., Dangl M., Berger A., & Haiden N. 2016.
abstract bibtex
abstract bibtex
Background and aims Preterm infants with extremely low birth weight (ELBW) are at increased risk of developing parenteral nutrition-associated cholestasis (PNAC). Fat emulsions containing fish oil are used in the treatment of PNAC. Whether PNACcan be prevented by primary use of fish oil containing fat emulsion for parenteral nutrition is little studied. In this study, we investigated to what extent fish oil containing lipid emulsion (SMOFlipid, SMOF) reduces the incidence of PNAC in ELBW preterm infants compared to a fat emulsion based on soybean oil (Intralipid, IL). Methods In this single-center prospective, randomized, double blind study either Intralipid or SMOFlipid was used for parenteral nutrition in ELBW infants. The primary outcome was PNAC (conjugated bilirubin \textgreater 1.5 mg/dl in two consecutive measurements during hospital stay). Results A total of 230 children were included and 207 infants were analyzed (IL: n=101, SMOF: n=106). The demographic parameters were evenly distributed between the two groups. PNAC incidence was 11.3% in the SMOF group and 14.9% in the IL group, which was not statistically significant (p=0.451). There were no differences in the incidence of morbidities associated with extreme prematurity such as ROP, culture proven sepsis or NEC. Conclusions The use of a fish oil containing fat emulsion (SMOFlipid) had no protective effect on PNAC incidence in ELBW infants at our center, with a generally low incidence of PNAC. Our data did not show any effect on ROP or sepsis.
@misc{repa_a._smoflipid_2016,
title = {Smoflipid for prevention of parenteral nutrition associated cholestasis in elbwinfants},
abstract = {Background and aims Preterm infants with extremely low birth weight (ELBW) are at increased risk of developing parenteral nutrition-associated cholestasis (PNAC). Fat emulsions containing fish oil are used in the treatment of PNAC. Whether PNACcan be prevented by primary use of fish oil containing fat emulsion for parenteral nutrition is little studied. In this study, we investigated to what extent fish oil containing lipid emulsion (SMOFlipid, SMOF) reduces the incidence of PNAC in ELBW preterm infants compared to a fat emulsion based on soybean oil (Intralipid, IL). Methods In this single-center prospective, randomized, double blind study either Intralipid or SMOFlipid was used for parenteral nutrition in ELBW infants. The primary outcome was PNAC (conjugated bilirubin {\textgreater} 1.5 mg/dl in two consecutive measurements during hospital stay). Results A total of 230 children were included and 207 infants were analyzed (IL: n=101, SMOF: n=106). The demographic parameters were evenly distributed between the two groups. PNAC incidence was 11.3\% in the SMOF group and 14.9\% in the IL group, which was not statistically significant (p=0.451). There were no differences in the incidence of morbidities associated with extreme prematurity such as ROP, culture proven sepsis or NEC. Conclusions The use of a fish oil containing fat emulsion (SMOFlipid) had no protective effect on PNAC incidence in ELBW infants at our center, with a generally low incidence of PNAC. Our data did not show any effect on ROP or sepsis.},
journal = {European Journal of Pediatrics},
author = {{Repa A.} and {Binder C.} and {Thanhaeuser M.} and {Kreissl A.} and {Dangl M.} and {Berger A.} and {Haiden N.}},
year = {2016},
keywords = {*cholestasis, *parenteral nutrition, Fish oil, Soybean oil, bilirubin glucuronide, clinical trial, controlled clinical trial, controlled study, double blind procedure, emulsion, extremely low birth weight, hospitalization, human, infant, lipid emulsion, major clinical study, morbidity, prematurity, prevention, randomized controlled trial, sepsis}
}Effect of zinc supplementation on infants with severe pneumonia. Yuan, X., Qian, S., Li, Z., & Zhang, Z. World journal of pediatrics : WJP, 12(2):166--9, 2016. Yuan, Xiao. Pediatric Department of Beijing Friendship Hospital, Capital Medical University, Beijing, China. Qian, Su-Yun. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, China. syqian1211@163.com. Qian, Su-Yun. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China. syqian1211@163.com. Li, Zheng. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, China. Zhang, Zhe-Zhe. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, China.
abstract bibtex
abstract bibtex
BACKGROUND: Pneumonia is a common respiratory infectious disease in infancy. Previous work shows controversial results on the benefit of zinc supplementation in patients with pneumonia. We conducted this study to investigate serum zinc status amongst infants with severe pneumonia and the clinical impact that zinc supplementation has on those patients with low serum zinc levels., METHODS: This study design was a non-blinded prospective randomized controlled trial. The study is approved by the Ethics Committees of Beijing Children's Hospital. A total of 96 infants diagnosed with severe pneumonia and hospitalized in the pediatric intensive care unit between November 2011 and January 2012 were enrolled. Enrolled patients were divided into low serum zinc and normal serum zinc group. The low serum zinc group was randomized into treatment and control groups. Only the treatment group received zinc supplementation within 48-72 hours after hospitalization., RESULTS: The prevalence of zinc deficiency on admission was 76.0%. The low zinc level was most apparent in infants between 1 and 3 months of age. The serum zinc level increased in the zinc treatment group and returned to a normal level (median, 53.20 mumol/L) on day 12+/-2. There was no statistical difference in the pediatric critic illness score, lung injury score, length of hospital stay, and duration of mechanical ventilation between the zinc treatment group and control group., CONCLUSION: Zinc deficiency is common in infants with severe pneumonia. Normalization of zinc levels with zinc supplementation did not improve clinical outcomes of infants with pneumonia.
@article{yuan_effect_2016,
title = {Effect of zinc supplementation on infants with severe pneumonia.},
volume = {12},
issn = {1867-0687},
abstract = {BACKGROUND: Pneumonia is a common respiratory infectious disease in infancy. Previous work shows controversial results on the benefit of zinc supplementation in patients with pneumonia. We conducted this study to investigate serum zinc status amongst infants with severe pneumonia and the clinical impact that zinc supplementation has on those patients with low serum zinc levels., METHODS: This study design was a non-blinded prospective randomized controlled trial. The study is approved by the Ethics Committees of Beijing Children's Hospital. A total of 96 infants diagnosed with severe pneumonia and hospitalized in the pediatric intensive care unit between November 2011 and January 2012 were enrolled. Enrolled patients were divided into low serum zinc and normal serum zinc group. The low serum zinc group was randomized into treatment and control groups. Only the treatment group received zinc supplementation within 48-72 hours after hospitalization., RESULTS: The prevalence of zinc deficiency on admission was 76.0\%. The low zinc level was most apparent in infants between 1 and 3 months of age. The serum zinc level increased in the zinc treatment group and returned to a normal level (median, 53.20 mumol/L) on day 12+/-2. There was no statistical difference in the pediatric critic illness score, lung injury score, length of hospital stay, and duration of mechanical ventilation between the zinc treatment group and control group., CONCLUSION: Zinc deficiency is common in infants with severe pneumonia. Normalization of zinc levels with zinc supplementation did not improve clinical outcomes of infants with pneumonia.},
number = {2},
journal = {World journal of pediatrics : WJP},
author = {Yuan, Xiao and Qian, Su-Yun and Li, Zheng and Zhang, Zhe-Zhe},
year = {2016},
note = {Yuan, Xiao. Pediatric Department of Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Qian, Su-Yun. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, China. syqian1211@163.com.
Qian, Su-Yun. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China. syqian1211@163.com.
Li, Zheng. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Zhang, Zhe-Zhe. PICU, Beijing Children's Hospital, Capital Medical University, Beijing, China.},
keywords = {*Community-Acquired Infections/co [Complications], *Pneumonia/co [Complications], *Zinc/df [Deficiency], *Zinc/tu [Therapeutic Use], Deficiency Diseases/dt [Drug Therapy], Deficiency Diseases/et [Etiology], Dietary Supplements, Humans, Prospective Studies, female, infant, male, severity of illness index},
pages = {166--9}
}Clonidine for Sedation and Analgesia and Withdrawal in Critically Ill Infants and Children. Capino A.C., Miller J.L., & Johnson P.N. 2016.
Paper abstract bibtex
Paper abstract bibtex The need for sedation and analgesia and treatment of iatrogenic drug withdrawal is common in critically ill children. First-line therapy typically includes opioid agonists. However, clonidine, a central alpha2 agonist, has been suggested as a treatment option for sedation and analgesia and iatrogenic drug withdrawal. Therefore, we conducted a literature search to identify articles evaluating the use of enteral (PO) and transdermal clonidine in critically ill infants and children for sedation and analgesia and treatment of iatrogenic drug withdrawal. The literature search was limited to English-language articles in Medline (1946-May 2016), Embase (1988-May 2016), and International Pharmaceutical Abstracts (1970-May 2016). Reference citations from relevant articles were also reviewed. Ten case reports and studies, representing a total of 114 children receiving clonidine, were included. Fifty patients (43.9%) received clonidine for sedation and analgesia while mechanically ventilated, and 33 (29.0%) received clonidine for treatment or prevention of drug withdrawal. The remaining 31 patients (27.1%) were included in a pharmacokinetic study that did not evaluate clinical outcomes. Seventy-nine patients (69.3%) received PO clonidine, with a dosage range of 2-15 micro g/kg/day divided every 6-8 hours. Thirty-five patients (30.7%) received transdermal clonidine, with a dosage range of 2.3-20 micro g/kg/day. Whole, cut, and occluded transdermal patches were used in the reports. Patients receiving cut patches had more variable and significantly higher serum clonidine concentrations than those receiving whole patches. Only three studies reported that the PO clonidine dose was tapered at the end of therapy; however, no report specifically described the process. The two most common adverse events reported with PO and transdermal clonidine were bradycardia and hypotension. PO and transdermal clonidine have a potential role for sedation and analgesia and drug withdrawal in critically ill infants and children. The use of cut transdermal patches should be avoided. Future prospective studies are needed to further define clonidine's role as adjunct therapy or monotherapy. Copyright © 2016 Pharmacotherapy Publications, Inc.
@misc{capino_a.c._clonidine_2016,
title = {Clonidine for {Sedation} and {Analgesia} and {Withdrawal} in {Critically} {Ill} {Infants} and {Children}},
url = {http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1875-9114/issues},
abstract = {The need for sedation and analgesia and treatment of iatrogenic drug withdrawal is common in critically ill children. First-line therapy typically includes opioid agonists. However, clonidine, a central alpha2 agonist, has been suggested as a treatment option for sedation and analgesia and iatrogenic drug withdrawal. Therefore, we conducted a literature search to identify articles evaluating the use of enteral (PO) and transdermal clonidine in critically ill infants and children for sedation and analgesia and treatment of iatrogenic drug withdrawal. The literature search was limited to English-language articles in Medline (1946-May 2016), Embase (1988-May 2016), and International Pharmaceutical Abstracts (1970-May 2016). Reference citations from relevant articles were also reviewed. Ten case reports and studies, representing a total of 114 children receiving clonidine, were included. Fifty patients (43.9\%) received clonidine for sedation and analgesia while mechanically ventilated, and 33 (29.0\%) received clonidine for treatment or prevention of drug withdrawal. The remaining 31 patients (27.1\%) were included in a pharmacokinetic study that did not evaluate clinical outcomes. Seventy-nine patients (69.3\%) received PO clonidine, with a dosage range of 2-15 micro g/kg/day divided every 6-8 hours. Thirty-five patients (30.7\%) received transdermal clonidine, with a dosage range of 2.3-20 micro g/kg/day. Whole, cut, and occluded transdermal patches were used in the reports. Patients receiving cut patches had more variable and significantly higher serum clonidine concentrations than those receiving whole patches. Only three studies reported that the PO clonidine dose was tapered at the end of therapy; however, no report specifically described the process. The two most common adverse events reported with PO and transdermal clonidine were bradycardia and hypotension. PO and transdermal clonidine have a potential role for sedation and analgesia and drug withdrawal in critically ill infants and children. The use of cut transdermal patches should be avoided. Future prospective studies are needed to further define clonidine's role as adjunct therapy or monotherapy. Copyright © 2016 Pharmacotherapy Publications, Inc.},
journal = {Pharmacotherapy},
author = {{Capino A.C.} and {Miller J.L.} and {Johnson P.N.}},
year = {2016},
keywords = {*analgesia, *clonidine, *clonidine/ae [Adverse Drug Reaction], *clonidine/cm [Drug Comparison], *clonidine/cr [Drug Concentration], *clonidine/ct [Clinical Trial], *clonidine/dt [Drug Therapy], *clonidine/po [Oral Drug Administration], *clonidine/td [Transdermal Drug Administration], *critically ill patient, *pediatric anesthesia, *sedation, *withdrawal syndrome/dt [Drug Therapy], *withdrawal syndrome/pc [Prevention], Child, Embase, English (language), Medline, Pharmacokinetics, adverse drug reaction, artificial ventilation, bradycardia, bradycardia/si [Side Effect], clinical outcome, drug blood level, drug dose increase, drug dose titration, drug induced disease, drug therapy, drug withdrawal, human, hypotension, hypotension/si [Side Effect], infant, intensive care, monotherapy, placebo, plasma half life, prospective study, respiratory failure/th [Therapy], review, side effect, single drug dose, systematic review, transdermal drug administration, transdermal patch, withdrawal syndrome/dt [Drug Therapy]}
}2015 (3)
Dexmedetomidine in the pediatric population: A review. Plambech M.Z. & Afshari A. 2015.
Paper abstract bibtex
Paper abstract bibtex Dexmedetomidine, an alpha-2 agonist approved only for sedation in adult intensive care patients, is increasingly used off-label in- and outside Europe in the pediatric setting for various indications such as to prevent agitation, as premedication in the form of intranasal, buccal and oral solution, as adjunct for elective surgery, as sedative for magnetic resonance imaging, as intraoperative analgesia, for extracorporeal shock wave lithotripsy, and as adjuvant to ropi- and bupivacaine for nerve blocks. Dexmedetomidine is also used intravenously at different intensive care units with the purpose of sedation of children. In this paper, we assess 51 minor trials in the form of 44 randomized controlled trials and 7 prospective observational studies in an attempt to update the available evidence on dexmedetomidine use in pediatrics. Furthermore, we discuss its potential indications, benefits and adverse effects. However, it is important to state that much of the existing evidence favoring dexmedetomidine in children is either extrapolated from adult studies or based on small randomized controlled trials and observational studies with their inherent methodological shortcomings and confounding factors. Based on the best current evidence dexmedetomidine is found suitable and safe for various indications. However, in order to discover its full potential, indications, dosing and safety profile for various ages and procedures, it should urgently be examined by conducting good quality pediatric trials. Finally, we provide the readers with guidance on how to apply and dose dexmedetomidine for pediatric sedation and for other indications. Copyright COPYRIGHT © 2015 EDIZIONI MINERVA MEDICA.
@misc{plambech_m.z._dexmedetomidine_2015,
title = {Dexmedetomidine in the pediatric population: {A} review},
url = {http://www.minervamedica.it/en/getpdf/sbNvoPlJhvv6bbyfsqY76tEZcB64PRPRZhQ7XFLHe60Q6OIPvcRxmU6QbTTdsDC59xcyai%252BPQuY95g446wPjIA%253D%253D/R02Y2015N03A0320.pdf},
abstract = {Dexmedetomidine, an alpha-2 agonist approved only for sedation in adult intensive care patients, is increasingly used off-label in- and outside Europe in the pediatric setting for various indications such as to prevent agitation, as premedication in the form of intranasal, buccal and oral solution, as adjunct for elective surgery, as sedative for magnetic resonance imaging, as intraoperative analgesia, for extracorporeal shock wave lithotripsy, and as adjuvant to ropi- and bupivacaine for nerve blocks. Dexmedetomidine is also used intravenously at different intensive care units with the purpose of sedation of children. In this paper, we assess 51 minor trials in the form of 44 randomized controlled trials and 7 prospective observational studies in an attempt to update the available evidence on dexmedetomidine use in pediatrics. Furthermore, we discuss its potential indications, benefits and adverse effects. However, it is important to state that much of the existing evidence favoring dexmedetomidine in children is either extrapolated from adult studies or based on small randomized controlled trials and observational studies with their inherent methodological shortcomings and confounding factors. Based on the best current evidence dexmedetomidine is found suitable and safe for various indications. However, in order to discover its full potential, indications, dosing and safety profile for various ages and procedures, it should urgently be examined by conducting good quality pediatric trials. Finally, we provide the readers with guidance on how to apply and dose dexmedetomidine for pediatric sedation and for other indications. Copyright COPYRIGHT © 2015 EDIZIONI MINERVA MEDICA.},
journal = {Minerva Anestesiologica},
author = {{Plambech M.Z.} and {Afshari A.}},
year = {2015},
keywords = {*anesthesia, *child, *deep sedation, *dexmedetomidine, *dexmedetomidine/ae [Adverse Drug Reaction], *dexmedetomidine/ct [Clinical Trial], *dexmedetomidine/na [Intranasal Drug Administration], *human, *pediatrics, *population, Child, Europe, adjuvant, adolescent, adult, adverse drug reaction, agitation, agonist, analgesia, article, bupivacaine, cardiovascular effect, clinical protocol, elective surgery, extracorporeal lithotripsy, human, infant, intensive care, intensive care unit, intranasal drug administration, intraoperative analgesia, intraoperative period, meta analysis (topic), nerve block, newborn, nuclear magnetic resonance imaging, observational study, patient, pediatrics, perioperative period, phase 1 clinical trial (topic), premedication, procedures, randomized controlled trial (topic), reading, safety, sedation, sedative agent, side effect/si [Side Effect], systematic review (topic)}
}Current Management of Neonatal Soft-tissue Sarcomas and Benign Tumors with Local Aggressiveness. Fernandez-Pineda, I., Neel, M. D., & Rao, B. N. Current Pediatric Reviews, 11(3):216--225, 2015.
abstract bibtex
abstract bibtex
Neonatal soft-tissue tumors are rare and comprise a heterogeneous group of neoplasms with substantial histological diversity. Treatment options include careful observation, primary surgical resection or medical therapy. Although histologically benign, some neoplasms do exhibit an aggressive local behavior. The most common soft-tissue sarcomas in this age group include rhabdomyosarcoma, fibrosarcoma, malignant rhabdoid tumor and hemangiopericytoma. Prenatal diagnosis on routine ultrasound or in the context of a known predisposition syndrome is increasingly becoming more common. Management of neonatal tumors requires a multidisciplinary team that includes obstetricians, neonatologists, pediatric oncologists, pediatric surgical specialists and psychological support for the family members. Treatment is particularly challenging due to the difficulty in appropriate dosing of chemotherapeutic agents or the limitations of the use of radiation therapy. Although surgical treatment is predominant in this age group, close observation may be appropriate, since spontaneous regression has been reported for certain histological subtypes.
@article{fernandez-pineda_current_2015,
title = {Current {Management} of {Neonatal} {Soft}-tissue {Sarcomas} and {Benign} {Tumors} with {Local} {Aggressiveness}},
volume = {11},
issn = {1875-6336},
abstract = {Neonatal soft-tissue tumors are rare and comprise a heterogeneous group of neoplasms with substantial histological diversity. Treatment options include careful observation, primary surgical resection or medical therapy. Although histologically benign, some neoplasms do exhibit an aggressive local behavior. The most common soft-tissue sarcomas in this age group include rhabdomyosarcoma, fibrosarcoma, malignant rhabdoid tumor and hemangiopericytoma. Prenatal diagnosis on routine ultrasound or in the context of a known predisposition syndrome is increasingly becoming more common. Management of neonatal tumors requires a multidisciplinary team that includes obstetricians, neonatologists, pediatric oncologists, pediatric surgical specialists and psychological support for the family members. Treatment is particularly challenging due to the difficulty in appropriate dosing of chemotherapeutic agents or the limitations of the use of radiation therapy. Although surgical treatment is predominant in this age group, close observation may be appropriate, since spontaneous regression has been reported for certain histological subtypes.},
language = {eng},
number = {3},
journal = {Current Pediatric Reviews},
author = {Fernandez-Pineda, Israel and Neel, Michael D. and Rao, Bhaskar N.},
year = {2015},
pmid = {26168942},
keywords = {Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Directive Counseling, Female, Fetal Diseases, Humans, Infant, Newborn, Infant, Newborn, Diseases, Interdisciplinary Communication, Neoplasm Invasiveness, Parents, Pregnancy, Prognosis, Radiotherapy Dosage, Sarcoma, Soft Tissue Neoplasms},
pages = {216--225}
}Topical Nystatin for the Prevention of Catheter-Associated Candidiasis in ELBW Infants. Bodin M.B., Godoy G., & Philips J.B. 2015.
abstract bibtex
abstract bibtex
BACKGROUND: Catheter-associated Candida bloodstream infections are a common and serious problem in the neonatal intensive care unit (NICU). Several prophylactic regimens have been developed including oral administration of nonabsorbable antifungals and intravenous infusions. No reports to date have employed a topical regimen., PURPOSE: To evaluate the effectiveness of topical nystatin cream in preventing catheter-associated Candida sepsis., METHODS: A retrospective descriptive design was used to determine the incidence of Candida sepsis in extremely low-birth weight (ELBW, \textless1000 g at birth) infants who were treated with topical nystatin cream for Candida bloodstream infection prophylaxis between January 1, 2000, and December 31, 2010. The electronic medical records of study infants were reviewed to establish the incidence of Candida sepsis., RESULTS: A total of 464 ELBW infants were admitted to the NICU during the study period. Three infants (0.65%) developed Candida sepsis., IMPLICATIONS FOR PRACTICE: These data demonstrate that a topical nystatin cream protocol is associated with a very low rate of Candida sepsis in ELBW infants with central catheters. The use of this protocol may contribute to a decrease in the morbidity and mortality rate associated with catheter-associated Candida infections in ELBW infants., IMPLICATIONS FOR RESEARCH: Before generalizations can be made as to the safety and efficacy of this protocol as compared to enteral and parenteral prophylactic treatments and in other institutions, large multicenter randomized controlled trials are required.
@misc{bodin_m.b._topical_2015,
title = {Topical {Nystatin} for the {Prevention} of {Catheter}-{Associated} {Candidiasis} in {ELBW} {Infants}},
abstract = {BACKGROUND: Catheter-associated Candida bloodstream infections are a common and serious problem in the neonatal intensive care unit (NICU). Several prophylactic regimens have been developed including oral administration of nonabsorbable antifungals and intravenous infusions. No reports to date have employed a topical regimen., PURPOSE: To evaluate the effectiveness of topical nystatin cream in preventing catheter-associated Candida sepsis., METHODS: A retrospective descriptive design was used to determine the incidence of Candida sepsis in extremely low-birth weight (ELBW, {\textless}1000 g at birth) infants who were treated with topical nystatin cream for Candida bloodstream infection prophylaxis between January 1, 2000, and December 31, 2010. The electronic medical records of study infants were reviewed to establish the incidence of Candida sepsis., RESULTS: A total of 464 ELBW infants were admitted to the NICU during the study period. Three infants (0.65\%) developed Candida sepsis., IMPLICATIONS FOR PRACTICE: These data demonstrate that a topical nystatin cream protocol is associated with a very low rate of Candida sepsis in ELBW infants with central catheters. The use of this protocol may contribute to a decrease in the morbidity and mortality rate associated with catheter-associated Candida infections in ELBW infants., IMPLICATIONS FOR RESEARCH: Before generalizations can be made as to the safety and efficacy of this protocol as compared to enteral and parenteral prophylactic treatments and in other institutions, large multicenter randomized controlled trials are required.},
journal = {Advances in neonatal care : official journal of the National Association of Neonatal Nurses},
author = {{Bodin M.B.} and {Godoy G.} and {Philips J.B.}},
year = {2015},
keywords = {*adverse effects, Catheter-Related Infections/pc [Prevention], Infant, Premature, Diseases/pc [Prevention], antifungal agent/ad [Drug Administration], antifungal agent/dt [Drug Therapy], candidiasis/pc [Prevention], central venous catheterization, female, human, infection control, male, newborn, nursing, nystatin/ad [Drug Administration], ointment, procedures, retrospective study, sepsis/pc [Prevention], therapeutic use, very low birth weight}
}2014 (4)
Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies. Munden, A., Butschek, R., Tom, W. L., Marshall, J. S., Poeltler, D. M., Krohne, S. E., Alió, A. B., Ritter, M., Friedlander, D. F., Catanzarite, V., Mendoza, A., Smith, L., Friedlander, M., & Friedlander, S. F. The British Journal of Dermatology, 170(4):907--913, April, 2014.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: The aetiology and exact incidence of infantile haemangiomas (IHs) are unknown. Prior studies have noted immunohistochemical and biological characteristics shared by IHs and placental tissue. OBJECTIVES: We investigated the possible association between placental anomalies and the development of IHs, as well as the demographic characteristics and other risk factors for IHs. PATIENTS AND METHODS: Pregnant women (n = 578) were prospectively enrolled and their offspring followed for 9 months. Placental evaluations were performed and demographic data collected on all mother-infant pairs. RESULTS: We evaluated 594 infants: 34 haemangiomas [either IH or congenital (CH)] were identified in 29 infants, yielding an incidence of 4·5% for IH (27 infants) and 0·3% for CH (two infants). Placental anomalies were noted in almost 35% of haemangioma-related pregnancies, approximately twice the incidence noted in pregnancies with unaffected infants (P = 0·025). Other risk factors for IH included prematurity (P = 0·016) and low birth weight (P = 0·028). All IHs were present by 3 months of age, and cessation of growth had occurred in all by 9 months of age. Most occurred on the trunk. Of note, 20% of identified IHs were abortive or telangiectatic in nature, small focal lesions that did not proliferate beyond 3 months of age. Only one IH required intervention. CONCLUSIONS: This is the first prospective American study to document the incidence of IHs in infants followed from birth to early infancy. The association with placental anomalies was statistically significant. The overall incidence mirrors prior estimates, but the need for treatment was lower than previously reported.
@article{munden_prospective_2014,
title = {Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies},
volume = {170},
issn = {1365-2133},
shorttitle = {Prospective study of infantile haemangiomas},
doi = {10.1111/bjd.12804},
abstract = {BACKGROUND: The aetiology and exact incidence of infantile haemangiomas (IHs) are unknown. Prior studies have noted immunohistochemical and biological characteristics shared by IHs and placental tissue.
OBJECTIVES: We investigated the possible association between placental anomalies and the development of IHs, as well as the demographic characteristics and other risk factors for IHs.
PATIENTS AND METHODS: Pregnant women (n = 578) were prospectively enrolled and their offspring followed for 9 months. Placental evaluations were performed and demographic data collected on all mother-infant pairs.
RESULTS: We evaluated 594 infants: 34 haemangiomas [either IH or congenital (CH)] were identified in 29 infants, yielding an incidence of 4·5\% for IH (27 infants) and 0·3\% for CH (two infants). Placental anomalies were noted in almost 35\% of haemangioma-related pregnancies, approximately twice the incidence noted in pregnancies with unaffected infants (P = 0·025). Other risk factors for IH included prematurity (P = 0·016) and low birth weight (P = 0·028). All IHs were present by 3 months of age, and cessation of growth had occurred in all by 9 months of age. Most occurred on the trunk. Of note, 20\% of identified IHs were abortive or telangiectatic in nature, small focal lesions that did not proliferate beyond 3 months of age. Only one IH required intervention.
CONCLUSIONS: This is the first prospective American study to document the incidence of IHs in infants followed from birth to early infancy. The association with placental anomalies was statistically significant. The overall incidence mirrors prior estimates, but the need for treatment was lower than previously reported.},
language = {eng},
number = {4},
journal = {The British Journal of Dermatology},
author = {Munden, A. and Butschek, R. and Tom, W. L. and Marshall, J. S. and Poeltler, D. M. and Krohne, S. E. and Alió, A. B. and Ritter, M. and Friedlander, D. F. and Catanzarite, V. and Mendoza, A. and Smith, L. and Friedlander, M. and Friedlander, S. F.},
month = apr,
year = {2014},
pmid = {24641194},
pmcid = {PMC4410180},
keywords = {Adolescent, Adult, California, Female, Hemangioma, Humans, Incidence, Infant, Male, Maternal Age, Middle Aged, Placenta Diseases, Pregnancy, Prospective Studies, Risk Factors, Young Adult},
pages = {907--913}
}Chickenpox and risk of stroke: a self-controlled case series analysis. Thomas, S. L., Minassian, C., Ganesan, V., Langan, S. M., & Smeeth, L. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 58(1):61--68, January, 2014.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: There is good evidence that respiratory and other infections that cause systemic inflammation can trigger strokes; however, the role of specific infections is unclear. Case reports have highlighted chickenpox as a possible risk factor for arterial ischemic stroke, particularly in children, but rigorous studies are needed to determine and quantify any increased risk. METHODS: We used anonymized electronic health records totaling \textgreater100 million person-years of observation from 4 UK primary care databases to identify individuals who had documented clinical chickenpox and a stroke or transient ischemic attack (TIA). Self-controlled case series methods were used to quantify any increased risk of first stroke or TIA in the 0-6 and 7-12 months following chickenpox compared to other observed time periods. We analyzed data within each database, and performed meta-analyses to obtain summary age-adjusted incidence ratios (IRs) separately for adults and children. RESULTS: Five hundred sixty eligible individuals (including 60 children) were identified who experienced chickenpox and a stroke or TIA during follow-up. Among children, there was a 4-fold increased risk of stroke in the 0-6 months after chickenpox (summary IR = 4.07; 95% confidence interval [CI], 1.96-8.45; I(2) = 0%). Among adults, there was a less marked increased risk with moderate between-database heterogeneity (random-effects summary IR = 2.13; 95% CI, 1.05-4.36; I(2) = 51%). There was no significant increased risk of stroke in the 7-12 months after chickenpox in children or adults, nor was there evidence of increased risk of TIA in either time period. CONCLUSIONS: Our study provides new evidence that children who experience chickenpox are at increased risk of stroke in the subsequent 6 months.
@article{thomas_chickenpox_2014,
title = {Chickenpox and risk of stroke: a self-controlled case series analysis},
volume = {58},
issn = {1537-6591},
shorttitle = {Chickenpox and risk of stroke},
doi = {10.1093/cid/cit659},
abstract = {BACKGROUND: There is good evidence that respiratory and other infections that cause systemic inflammation can trigger strokes; however, the role of specific infections is unclear. Case reports have highlighted chickenpox as a possible risk factor for arterial ischemic stroke, particularly in children, but rigorous studies are needed to determine and quantify any increased risk.
METHODS: We used anonymized electronic health records totaling {\textgreater}100 million person-years of observation from 4 UK primary care databases to identify individuals who had documented clinical chickenpox and a stroke or transient ischemic attack (TIA). Self-controlled case series methods were used to quantify any increased risk of first stroke or TIA in the 0-6 and 7-12 months following chickenpox compared to other observed time periods. We analyzed data within each database, and performed meta-analyses to obtain summary age-adjusted incidence ratios (IRs) separately for adults and children.
RESULTS: Five hundred sixty eligible individuals (including 60 children) were identified who experienced chickenpox and a stroke or TIA during follow-up. Among children, there was a 4-fold increased risk of stroke in the 0-6 months after chickenpox (summary IR = 4.07; 95\% confidence interval [CI], 1.96-8.45; I(2) = 0\%). Among adults, there was a less marked increased risk with moderate between-database heterogeneity (random-effects summary IR = 2.13; 95\% CI, 1.05-4.36; I(2) = 51\%). There was no significant increased risk of stroke in the 7-12 months after chickenpox in children or adults, nor was there evidence of increased risk of TIA in either time period.
CONCLUSIONS: Our study provides new evidence that children who experience chickenpox are at increased risk of stroke in the subsequent 6 months.},
language = {eng},
number = {1},
journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
author = {Thomas, Sara L. and Minassian, Caroline and Ganesan, Vijeya and Langan, Sinéad M. and Smeeth, Liam},
month = jan,
year = {2014},
pmid = {24092802},
pmcid = {PMC3864501},
keywords = {Adult, Aged, Chickenpox, Child, Child, Preschool, Female, Great Britain, Humans, Infant, Male, Middle Aged, Risk Assessment, Risk Factors, Time Factors, incidence, stroke},
pages = {61--68}
}Serious adverse effects from single-use detergent sacs: report from a U.S. statewide poison control system. Huntington, S., Heppner, J., Vohra, R., Mallios, R., & Geller, R. J. Clinical Toxicology (Philadelphia, Pa.), 52(3):220--225, March, 2014.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: In recent years, serious adverse effects to children from exposure to single-use detergents sacs (SUDS) have been recognized. While most exposures result in minor symptoms, there have been serious outcomes. This study aims to classify which types of serious outcomes follow SUDS exposures, and to assess, if possible, differences in toxicity between various SUDS products. METHODS: An observational case series with data collected retrospectively was performed for cases of SUDS exposures reported to a statewide poison system's records database from 1 January 2012 to 31 March 2013. Cases were identified and analyzed for clinical details and trends. A statewide database was queried for cases involving the American Association of Poison Control Centers (AAPCC) product-specific codes for SUDS products using following search terms: laundry pods, the AAPCC product-specific codes for Tide Pods, Purex Ultrapacks, ALL Mighty Pacs, and a unique agent code (AAPCC ID: 6903138; Generic: 077900) created by AAPCC to track SUDS exposures. RESULTS: A total of 804 cases of exposures to SUDS were identified, the majority of which were exploratory ingestions in young children with a median age of 2 years. Serious adverse effects resulted from 65 (9%) exposures and 27 (3%) exposures resulted in admission to hospital. Binary logistic regression demonstrated that the presence of central nervous system (CNS) or respiratory system effects were associated with more severe outcomes, with a model accuracy of 96.4%. There were significant differences in morbidity among the three most common brand-name products: when compared with Tide Pods, odds ratios (OR) and 95% confidence intervals (CI) for severe outcome and admission rate were significantly greater following Purex Ultrapack exposures (severity OR 5.1 [CI: 2.13-12.23]; admission OR 10.36 [CI: 3.23-33.22]) and ALL Mighty Pac exposures (severity OR 11.22 [CI: 4.78-28.36]; admission OR 15.20 [CI: 5.01-46.12]). CONCLUSIONS: Serious complications from exposure to SUDS occur in a small number of exposures for unclear reasons. Respiratory and CNS effects are associated with more severe outcomes. Some brand-name products are associated with a relatively higher risk of severe adverse effects and rates of admission.
@article{huntington_serious_2014,
title = {Serious adverse effects from single-use detergent sacs: report from a {U}.{S}. statewide poison control system},
volume = {52},
issn = {1556-9519},
shorttitle = {Serious adverse effects from single-use detergent sacs},
doi = {10.3109/15563650.2014.892122},
abstract = {BACKGROUND: In recent years, serious adverse effects to children from exposure to single-use detergents sacs (SUDS) have been recognized. While most exposures result in minor symptoms, there have been serious outcomes. This study aims to classify which types of serious outcomes follow SUDS exposures, and to assess, if possible, differences in toxicity between various SUDS products.
METHODS: An observational case series with data collected retrospectively was performed for cases of SUDS exposures reported to a statewide poison system's records database from 1 January 2012 to 31 March 2013. Cases were identified and analyzed for clinical details and trends. A statewide database was queried for cases involving the American Association of Poison Control Centers (AAPCC) product-specific codes for SUDS products using following search terms: laundry pods, the AAPCC product-specific codes for Tide Pods, Purex Ultrapacks, ALL Mighty Pacs, and a unique agent code (AAPCC ID: 6903138; Generic: 077900) created by AAPCC to track SUDS exposures.
RESULTS: A total of 804 cases of exposures to SUDS were identified, the majority of which were exploratory ingestions in young children with a median age of 2 years. Serious adverse effects resulted from 65 (9\%) exposures and 27 (3\%) exposures resulted in admission to hospital. Binary logistic regression demonstrated that the presence of central nervous system (CNS) or respiratory system effects were associated with more severe outcomes, with a model accuracy of 96.4\%. There were significant differences in morbidity among the three most common brand-name products: when compared with Tide Pods, odds ratios (OR) and 95\% confidence intervals (CI) for severe outcome and admission rate were significantly greater following Purex Ultrapack exposures (severity OR 5.1 [CI: 2.13-12.23]; admission OR 10.36 [CI: 3.23-33.22]) and ALL Mighty Pac exposures (severity OR 11.22 [CI: 4.78-28.36]; admission OR 15.20 [CI: 5.01-46.12]).
CONCLUSIONS: Serious complications from exposure to SUDS occur in a small number of exposures for unclear reasons. Respiratory and CNS effects are associated with more severe outcomes. Some brand-name products are associated with a relatively higher risk of severe adverse effects and rates of admission.},
language = {eng},
number = {3},
journal = {Clinical Toxicology (Philadelphia, Pa.)},
author = {Huntington, S. and Heppner, J. and Vohra, R. and Mallios, R. and Geller, R. J.},
month = mar,
year = {2014},
pmid = {24580062},
keywords = {Adolescent, Child, Child, Preschool, Detergents, Humans, Infant, Infant, Newborn, Logistic Models, Poison Control Centers, Retrospective Studies, United States},
pages = {220--225}
}International comparisons of the consultation prevalence of musculoskeletal conditions using population-based healthcare data from England and Sweden. Jordan, K. P., Joud, A., Bergknut, C., Croft, P., Edwards, J. J., Peat, G., Petersson, I. F., Turkiewicz, A., Wilkie, R., & Englund, M. Annals of the rheumatic diseases, 73(1):212–218, January, 2014.
Paper doi abstract bibtex
Paper doi abstract bibtex OBJECTIVES: To assess the consultation prevalence of musculoskeletal (MSK) conditions as presented in different healthcare systems, and to determine the feasibility of comparing prevalence figures between nations. METHODS: The settings were an English regional database (Consultations in Primary Care Archive (CiPCA)) and the Swedish Skane County Health Care Register. Case definitions, data extraction and analysis procedures were harmonised. The number of people consulting per 10 000 registered population in primary care, and in primary or secondary care, in the year 2010 (annual consultation prevalence) were determined for doctor-diagnosed osteoarthritis (OA), rheumatoid arthritis (RA), low back pain, and spondyloarthritis including psoriatic arthritis and ankylosing spondylitis (AS). Seven-year period consultation prevalences were also determined. RESULTS: Combining primary and secondary care, annual consultation prevalences of any MSK condition (2143 vs 1610/10 000) and low back pain (587 vs 294/10 000) were higher in England than in Sweden, but higher for RA, spondyloarthritis and psoriatic arthritis in Sweden. Annual primary care prevalence figures for OA (176 vs 196/10 000), RA (25 vs 26/10 000), spondyloarthritis (both 8/10 000) and psoriatic arthritis (5 vs 3/10 000) were similar between England and Sweden. AS was rarely recorded in Swedish primary care. These patterns were also observed for 7-year period consultation prevalences. CONCLUSIONS: A rigorous methodological approach allowed feasible comparison of MSK consultation prevalence between England and Sweden. Differences in prevalence of inflammatory and unspecific pain conditions may be partially explained by known variations in healthcare systems and recording practice. Routine healthcare data offers potential for investigating variations in occurrence and outcome of MSK conditions between nations.
@article{jordan_international_2014,
title = {International comparisons of the consultation prevalence of musculoskeletal conditions using population-based healthcare data from {England} and {Sweden}.},
volume = {73},
issn = {1468-2060 0003-4967},
url = {http://dx.doi.org/10.1136%2Fannrheumdis-2012-202634},
doi = {10.1136/annrheumdis-2012-202634},
abstract = {OBJECTIVES: To assess the consultation prevalence of musculoskeletal (MSK) conditions as presented in different healthcare systems, and to determine the feasibility of comparing prevalence figures between nations. METHODS: The settings were an English regional database (Consultations in Primary Care Archive (CiPCA)) and the Swedish Skane County Health Care Register. Case definitions, data extraction and analysis procedures were harmonised. The number of people consulting per 10 000 registered population in primary care, and in primary or secondary care, in the year 2010 (annual consultation prevalence) were determined for doctor-diagnosed osteoarthritis (OA), rheumatoid arthritis (RA), low back pain, and spondyloarthritis including psoriatic arthritis and ankylosing spondylitis (AS). Seven-year period consultation prevalences were also determined. RESULTS: Combining primary and secondary care, annual consultation prevalences of any MSK condition (2143 vs 1610/10 000) and low back pain (587 vs 294/10 000) were higher in England than in Sweden, but higher for RA, spondyloarthritis and psoriatic arthritis in Sweden. Annual primary care prevalence figures for OA (176 vs 196/10 000), RA (25 vs 26/10 000), spondyloarthritis (both 8/10 000) and psoriatic arthritis (5 vs 3/10 000) were similar between England and Sweden. AS was rarely recorded in Swedish primary care. These patterns were also observed for 7-year period consultation prevalences. CONCLUSIONS: A rigorous methodological approach allowed feasible comparison of MSK consultation prevalence between England and Sweden. Differences in prevalence of inflammatory and unspecific pain conditions may be partially explained by known variations in healthcare systems and recording practice. Routine healthcare data offers potential for investigating variations in occurrence and outcome of MSK conditions between nations.},
language = {eng},
number = {1},
journal = {Annals of the rheumatic diseases},
author = {Jordan, Kelvin P. and Joud, Anna and Bergknut, Charlotte and Croft, Peter and Edwards, John J. and Peat, George and Petersson, Ingemar F. and Turkiewicz, Aleksandra and Wilkie, Ross and Englund, Martin},
month = jan,
year = {2014},
pmid = {23345602},
pmcid = {PMC3888586},
keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Arthralgia/*epidemiology, Child, Child, Preschool, Cross-Cultural Comparison, Databases, Factual/statistics \& numerical data, EPIDEMIOLOGY, England/epidemiology, Female, Humans, Infant, Infant, Newborn, Low Back Pain, Male, Middle Aged, Morbidity, Musculoskeletal Diseases/*epidemiology, Osteoarthritis, Osteoarthritis/*epidemiology, Prevalence, Primary Health Care/*statistics \& numerical data, RHEUMATOID ARTHRITIS, Referral and Consultation/*statistics \& numerical data, Spondyloarthritis, Sweden/epidemiology, Young Adult},
pages = {212--218},
}2013 (11)
Epidemiological features and risk factors of Salmonella gastroenteritis in children resident in Ho Chi Minh City, Vietnam. Thompson, C. N., Phan, V. T. M., Le, T. P. T., Pham, T. N. T., Hoang, L. P., Ha, V., Nguyen, V. M. H., Pham, V. M., Nguyen, T. V., Cao, T. T., Tran, T. T. N., Nguyen, T. T. H., Dao, M. T., Campbell, J. I., Nguyen, T. C., Tang, C. T., Ha, M. T., Farrar, J., & Baker, S. Epidemiology and infection, 141(8):1604–1613, August, 2013.
doi abstract bibtex
doi abstract bibtex
Non-typhoidal Salmonella are an important but poorly characterized cause of paediatric diarrhoea in developing countries. We conducted a hospital-based case-control study in children aged \textless5 years in Ho Chi Minh City to define the epidemiology and examine risk factors associated with Salmonella diarrhoeal infections. From 1419 diarrhoea cases and 571 controls enrolled between 2009 and 2010, 77 (54%) diarrhoea cases were stool culture-positive for non-typhoidal Salmonella. Salmonella patients were more likely to be younger than controls (median age 10 and 12 months, respectively) [odds ratio (OR) 097; 95% confidence interval (CI) 094-099], to report a recent diarrhoeal contact (81% cases, 18% controls; OR 598, 95% CI 18-204) and to live in a household with \textgreater2 children (cases 208%, controls 102%; OR 232, 95% CI 12-47). Our findings indicate that Salmonella are an important cause of paediatric gastroenteritis in this setting and we suggest that transmission may occur through direct human contact in the home.
@article{thompson_epidemiological_2013,
title = {Epidemiological features and risk factors of {Salmonella} gastroenteritis in children resident in {Ho} {Chi} {Minh} {City}, {Vietnam}.},
volume = {141},
issn = {1469-4409 0950-2688},
doi = {10.1017/S0950268812002014},
abstract = {Non-typhoidal Salmonella are an important but poorly characterized cause of paediatric diarrhoea in developing countries. We conducted a hospital-based case-control study in children aged {\textless}5 years in Ho Chi Minh City to define the epidemiology and examine risk factors associated with Salmonella diarrhoeal infections. From 1419 diarrhoea cases and 571 controls enrolled between 2009 and 2010, 77 (54\%) diarrhoea cases were stool culture-positive for non-typhoidal Salmonella. Salmonella patients were more likely to be younger than controls (median age 10 and 12 months, respectively) [odds ratio (OR) 097; 95\% confidence interval (CI) 094-099], to report a recent diarrhoeal contact (81\% cases, 18\% controls; OR 598, 95\% CI 18-204) and to live in a household with {\textgreater}2 children (cases 208\%, controls 102\%; OR 232, 95\% CI 12-47). Our findings indicate that Salmonella are an important cause of paediatric gastroenteritis in this setting and we suggest that transmission may occur through direct human contact in the home.},
language = {eng},
number = {8},
journal = {Epidemiology and infection},
author = {Thompson, C. N. and Phan, V. T. M. and Le, T. P. T. and Pham, T. N. T. and Hoang, L. P. and Ha, V. and Nguyen, V. M. H. and Pham, V. M. and Nguyen, T. V. and Cao, T. T. and Tran, T. T. N. and Nguyen, T. T. H. and Dao, M. T. and Campbell, J. I. and Nguyen, T. C. and Tang, C. T. and Ha, M. T. and Farrar, J. and Baker, S.},
month = aug,
year = {2013},
pmid = {23010148},
pmcid = {PMC3733064},
keywords = {*Developing Countries, Bacterial Typing Techniques, Case-Control Studies, Child, Preschool, Diarrhea/*epidemiology/microbiology, Feces/microbiology, Female, Gastroenteritis/*epidemiology/microbiology, Humans, Infant, Male, Prevalence, Risk Factors, Salmonella Infections/*epidemiology/microbiology/transmission, Salmonella/*isolation \& purification, Surveys and Questionnaires, Urban Population, Vietnam/epidemiology},
pages = {1604--1613},
}Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. Tan, L. V., van Doorn, H. R., Nghia, H. D. T., Chau, T. T. H., Tu, L. T. P., de Vries, M., Canuti, M., Deijs, M., Jebbink, M. F., Baker, S., Bryant, J. E., Tham, N. T., BKrong, N. T. T. C., Boni, M. F., Loi, T. Q., Phuong, L. T., Verhoeven, J. T. P., Crusat, M., Jeeninga, R. E., Schultsz, C., Chau, N. V. V., Hien, T. T., van der Hoek, L., Farrar, J., & de Jong, M. D. mBio, 4(3):e00231–00213, June, 2013.
doi abstract bibtex
doi abstract bibtex
Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus.
@article{tan_identification_2013,
title = {Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections.},
volume = {4},
issn = {2150-7511},
doi = {10.1128/mBio.00231-13},
abstract = {Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4\% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58\%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus.},
language = {eng},
number = {3},
journal = {mBio},
author = {Tan, Le Van and van Doorn, H. Rogier and Nghia, Ho Dang Trung and Chau, Tran Thi Hong and Tu, Le Thi Phuong and de Vries, Michel and Canuti, Marta and Deijs, Martin and Jebbink, Maarten F. and Baker, Stephen and Bryant, Juliet E. and Tham, Nguyen Thi and BKrong, Nguyen Thi Thuy Chinh and Boni, Maciej F. and Loi, Tran Quoc and Phuong, Le Thi and Verhoeven, Joost T. P. and Crusat, Martin and Jeeninga, Rienk E. and Schultsz, Constance and Chau, Nguyen Van Vinh and Hien, Tran Tinh and van der Hoek, Lia and Farrar, Jeremy and de Jong, Menno D.},
month = jun,
year = {2013},
pmid = {23781068},
pmcid = {PMC3684831},
keywords = {Adolescent, Adult, Aged, Animals, Central Nervous System Infections/epidemiology/*virology, Child, Child, Preschool, Circoviridae Infections/epidemiology/*virology, Circoviridae/*classification/genetics/*isolation \& purification, Cluster Analysis, DNA, Viral/chemistry/genetics, Female, Genome, Viral, Humans, Infant, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Prevalence, Prospective Studies, Sequence Analysis, DNA, Vietnam, Young Adult},
pages = {e00231--00213},
}Comparison of three methods (an updated logistic probabilistic method, the Naranjo and Liverpool algorithms) for the evaluation of routine pharmacovigilance case reports using consensual expert judgement as reference. Théophile, H., André, M., Miremont-Salamé, G., Arimone, Y., & Bégaud, B. Drug Safety, 36(10):1033–1044, October, 2013.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: An updated probabilistic causality assessment method and the Liverpool algorithm presented as an improved version of the Naranjo algorithm, one of the most used and accepted causality assessment methods, have recently been proposed. OBJECTIVE: In order to test the validity of the probabilistic method in routine pharmacovigilance, results provided by the Naranjo and Liverpool algorithms, as well as the updated probabilistic method, were each compared with a consensual expert judgement taken as reference. METHODS: A sample of 59 drug-event pairs randomly sampled from spontaneous reports to the French pharmacovigilance system was assessed by expert judgement until reaching consensus and by members of a pharmacovigilance unit using the updated probabilistic method, the Naranjo and Liverpool algorithms. Probabilities given by the probabilistic method, and categories obtained by both the Naranjo and the Liverpool algorithms were compared as well as their sensitivity, specificity, positive and negative predictive values. RESULTS: The median probability for drug causation given by the consensual expert judgement was 0.70 (inter-quartile range, IQR 0.54-0.84) versus 0.77 (IQR 0.54-0.91) for the probabilistic method. For the Naranjo algorithm, the 'possible' causality category was predominant (61 %), followed by 'probable' (35 %), 'doubtful', and 'almost certain' categories (2 % each). Category distribution obtained with the Liverpool algorithm was similar to that obtained by the Naranjo algorithm with a majority of 'possible' (61 %) and 'probable' (30 %) followed by 'definite' (7 %) and 'unlikely' (2 %). For the probabilistic method, sensitivity, specificity, positive and negative predictive values were 0.96, 0.56, 0.92 and 0.71, respectively. For the Naranjo algorithm, depending on whether the 'possible' category was considered in favour or in disfavour of drug causation, sensitivity was, respectively, 1 or 0.42, specificity 0.11 or 0.89, negative predictive value 1 or 0.22 and positive predictive value 0.86 or 0.95; results were identical for the Liverpool algorithm. CONCLUSION: The logistic probabilistic method gave results closer to the consensual expert judgment than either the Naranjo or Liverpool algorithms whose performance were strongly dependent on the meaning given to the 'possible' category. Owing to its good sensitivity and positive predictive value and by providing results as continuous probabilities, the probabilistic method seems worthy to use for a trustable assessment of adverse drug reactions in routine practice.
@article{theophile_comparison_2013,
title = {Comparison of three methods (an updated logistic probabilistic method, the {Naranjo} and {Liverpool} algorithms) for the evaluation of routine pharmacovigilance case reports using consensual expert judgement as reference},
volume = {36},
issn = {1179-1942},
doi = {10.1007/s40264-013-0083-1},
abstract = {BACKGROUND: An updated probabilistic causality assessment method and the Liverpool algorithm presented as an improved version of the Naranjo algorithm, one of the most used and accepted causality assessment methods, have recently been proposed.
OBJECTIVE: In order to test the validity of the probabilistic method in routine pharmacovigilance, results provided by the Naranjo and Liverpool algorithms, as well as the updated probabilistic method, were each compared with a consensual expert judgement taken as reference.
METHODS: A sample of 59 drug-event pairs randomly sampled from spontaneous reports to the French pharmacovigilance system was assessed by expert judgement until reaching consensus and by members of a pharmacovigilance unit using the updated probabilistic method, the Naranjo and Liverpool algorithms. Probabilities given by the probabilistic method, and categories obtained by both the Naranjo and the Liverpool algorithms were compared as well as their sensitivity, specificity, positive and negative predictive values.
RESULTS: The median probability for drug causation given by the consensual expert judgement was 0.70 (inter-quartile range, IQR 0.54-0.84) versus 0.77 (IQR 0.54-0.91) for the probabilistic method. For the Naranjo algorithm, the 'possible' causality category was predominant (61 \%), followed by 'probable' (35 \%), 'doubtful', and 'almost certain' categories (2 \% each). Category distribution obtained with the Liverpool algorithm was similar to that obtained by the Naranjo algorithm with a majority of 'possible' (61 \%) and 'probable' (30 \%) followed by 'definite' (7 \%) and 'unlikely' (2 \%). For the probabilistic method, sensitivity, specificity, positive and negative predictive values were 0.96, 0.56, 0.92 and 0.71, respectively. For the Naranjo algorithm, depending on whether the 'possible' category was considered in favour or in disfavour of drug causation, sensitivity was, respectively, 1 or 0.42, specificity 0.11 or 0.89, negative predictive value 1 or 0.22 and positive predictive value 0.86 or 0.95; results were identical for the Liverpool algorithm.
CONCLUSION: The logistic probabilistic method gave results closer to the consensual expert judgment than either the Naranjo or Liverpool algorithms whose performance were strongly dependent on the meaning given to the 'possible' category. Owing to its good sensitivity and positive predictive value and by providing results as continuous probabilities, the probabilistic method seems worthy to use for a trustable assessment of adverse drug reactions in routine practice.},
language = {eng},
number = {10},
journal = {Drug Safety},
author = {Théophile, Hélène and André, Manon and Miremont-Salamé, Ghada and Arimone, Yannick and Bégaud, Bernard},
month = oct,
year = {2013},
pmid = {23828659},
keywords = {Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Algorithms, Child, Preschool, Consensus, Drug-Related Side Effects and Adverse Reactions, Expert Testimony, Female, France, Humans, Infant, Judgment, Logistic Models, Male, Middle Aged, Pharmaceutical Preparations, Pharmacovigilance, Sensitivity and Specificity},
pages = {1033--1044}
}Socio-economic position and childhood multimorbidity: a study using linkage between the Avon Longitudinal Study of Parents and Children and the General Practice Research Database. Cornish, R. P., Boyd, A., Van Staa, T., Salisbury, C., & Macleod, J. International Journal for Equity in Health, 12:66, 2013.
doi abstract bibtex
doi abstract bibtex
INTRODUCTION: In adults, multimorbidity is associated with social position. Socially disadvantaged adults typically experience more chronic illness at a younger age than comparable individuals who are more advantaged. The relation between social position and multimorbidity amongst children and adolescents has not been as widely studied and is less clear. METHODS: The NHS Information Centre (NHS IC) linked participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) to the General Practice Research Database (GPRD). Multimorbidity was measured in three different ways: using a count of the number of drugs prescribed, a count of chronic diseases, and a person's predicted resource use score; the latter two measures were derived using the Johns Hopkins ACG system. A number of different socio-economic position variables measured as part of ALSPAC during pregnancy and early childhood were considered. Ordered logistic and negative binomial regression models were used to investigate associations between socio-economic variables and multimorbidity. RESULTS: After mutually adjusting for the different markers of socio-economic position, there was evidence, albeit weak, that chronic condition counts among children aged from 0 to 9 years were higher among those whose mothers were less well educated (OR = 0.44; 95% confidence interval 0.18-1.10; p = 0.08). Conversely, children whose mothers were better educated had higher rates of chronic illness between 10 and 18 years (OR = 1.94; 95% CI 1.14-3.30). However, living in a more deprived area, as indicated by the Townsend score, was associated with a higher odds of chronic illness between 10 and 18 years (OR for each increasing decile of Townsend score = 1.09; 95% CI 1.00-1.19; p = 0.06). CONCLUSIONS: We have found some evidence that, in younger children, multimorbidity may be higher amongst children whose parents are less well educated. In older children and adolescents this association is less clear. We have also demonstrated that linkage between prospective observational studies and electronic patient records can provide an effective way of obtaining objectively measured outcome variables.
@article{cornish_socio-economic_2013,
title = {Socio-economic position and childhood multimorbidity: a study using linkage between the {Avon} {Longitudinal} {Study} of {Parents} and {Children} and the {General} {Practice} {Research} {Database}},
volume = {12},
issn = {1475-9276},
shorttitle = {Socio-economic position and childhood multimorbidity},
doi = {10.1186/1475-9276-12-66},
abstract = {INTRODUCTION: In adults, multimorbidity is associated with social position. Socially disadvantaged adults typically experience more chronic illness at a younger age than comparable individuals who are more advantaged. The relation between social position and multimorbidity amongst children and adolescents has not been as widely studied and is less clear.
METHODS: The NHS Information Centre (NHS IC) linked participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) to the General Practice Research Database (GPRD). Multimorbidity was measured in three different ways: using a count of the number of drugs prescribed, a count of chronic diseases, and a person's predicted resource use score; the latter two measures were derived using the Johns Hopkins ACG system. A number of different socio-economic position variables measured as part of ALSPAC during pregnancy and early childhood were considered. Ordered logistic and negative binomial regression models were used to investigate associations between socio-economic variables and multimorbidity.
RESULTS: After mutually adjusting for the different markers of socio-economic position, there was evidence, albeit weak, that chronic condition counts among children aged from 0 to 9 years were higher among those whose mothers were less well educated (OR = 0.44; 95\% confidence interval 0.18-1.10; p = 0.08). Conversely, children whose mothers were better educated had higher rates of chronic illness between 10 and 18 years (OR = 1.94; 95\% CI 1.14-3.30). However, living in a more deprived area, as indicated by the Townsend score, was associated with a higher odds of chronic illness between 10 and 18 years (OR for each increasing decile of Townsend score = 1.09; 95\% CI 1.00-1.19; p = 0.06).
CONCLUSIONS: We have found some evidence that, in younger children, multimorbidity may be higher amongst children whose parents are less well educated. In older children and adolescents this association is less clear. We have also demonstrated that linkage between prospective observational studies and electronic patient records can provide an effective way of obtaining objectively measured outcome variables.},
language = {eng},
journal = {International Journal for Equity in Health},
author = {Cornish, Rosie P. and Boyd, Andy and Van Staa, Tjeerd and Salisbury, Chris and Macleod, John},
year = {2013},
pmid = {23962118},
pmcid = {PMC3751770},
keywords = {Adolescent, Child, Child, Preschool, Chronic Disease, Comorbidity, Drug Prescriptions, Educational Status, Family Practice, Female, Great Britain, Humans, Infant, Male, Parents, Regression Analysis, Socioeconomic Factors},
pages = {66}
}An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population. Hall, G. C., Morant, S. V., Carroll, D., Gabriel, Z. L., & McQuay, H. J. BMC family practice, 14:28, 2013.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: This study updated our knowledge of UK primary care neuropathic pain incidence rates and prescribing practices. METHODS: Patients with a first diagnosis of post-herpetic neuralgia (PHN), painful diabetic neuropathy (PDN) or phantom limb pain (PLP) were identified from the General Practice Research Database (2006 - 2010) and incidence rates were calculated. Prescription records were searched for pain treatments from diagnosis of these conditions and the duration and daily dose estimated for first-line and subsequent treatment regimens. Recording of neuropathic back and post-operative pain was investigated. RESULTS: The study included 5,920 patients with PHN, 5,340 with PDN, and 185 with PLP. The incidence per 10,000 person-years was 3.4 (95% CI 3.4, 3.5) for PHN; and 0.11 (95% CI 0.09, 0.12) for PLP. Validation of the PDN case definition suggested that was not sensitive. Incident PHN increased over the study period. The most common first-line treatments were amitriptyline or gabapentin in the PDN and PLP cohorts, and amitriptyline or co-codamol (codeine-paracetamol) in PHN. Paracetamol, co-dydramol (paracetamol-dihydrocodeine) and capsaicin were also often prescribed in one or more condition. Most first-line treatments comprised only one therapeutic class. Use of antiepileptics licensed for neuropathic pain treatment had increased since 2002-2005. Amitriptyline was the only antidepressant prescribed commonly as a first-line treatment. CONCLUSION: The UK incidence of diagnosed PHN has increased with the incidence of back-pain and post-operative pain unclear. While use of licensed antiepileptics increased, prescribing of therapy with little evidence of efficacy in neuropathic pain is still common and consequently treatment was often not in-line with current guidance.
@article{hall_observational_2013,
title = {An observational descriptive study of the epidemiology and treatment of neuropathic pain in a {UK} general population},
volume = {14},
issn = {1471-2296},
doi = {10.1186/1471-2296-14-28},
abstract = {BACKGROUND: This study updated our knowledge of UK primary care neuropathic pain incidence rates and prescribing practices.
METHODS: Patients with a first diagnosis of post-herpetic neuralgia (PHN), painful diabetic neuropathy (PDN) or phantom limb pain (PLP) were identified from the General Practice Research Database (2006 - 2010) and incidence rates were calculated. Prescription records were searched for pain treatments from diagnosis of these conditions and the duration and daily dose estimated for first-line and subsequent treatment regimens. Recording of neuropathic back and post-operative pain was investigated.
RESULTS: The study included 5,920 patients with PHN, 5,340 with PDN, and 185 with PLP. The incidence per 10,000 person-years was 3.4 (95\% CI 3.4, 3.5) for PHN; and 0.11 (95\% CI 0.09, 0.12) for PLP. Validation of the PDN case definition suggested that was not sensitive. Incident PHN increased over the study period. The most common first-line treatments were amitriptyline or gabapentin in the PDN and PLP cohorts, and amitriptyline or co-codamol (codeine-paracetamol) in PHN. Paracetamol, co-dydramol (paracetamol-dihydrocodeine) and capsaicin were also often prescribed in one or more condition. Most first-line treatments comprised only one therapeutic class. Use of antiepileptics licensed for neuropathic pain treatment had increased since 2002-2005. Amitriptyline was the only antidepressant prescribed commonly as a first-line treatment.
CONCLUSION: The UK incidence of diagnosed PHN has increased with the incidence of back-pain and post-operative pain unclear. While use of licensed antiepileptics increased, prescribing of therapy with little evidence of efficacy in neuropathic pain is still common and consequently treatment was often not in-line with current guidance.},
language = {eng},
journal = {BMC family practice},
author = {Hall, Gillian C. and Morant, Steve V. and Carroll, Dawn and Gabriel, Zahava L. and McQuay, Henry J.},
year = {2013},
pmid = {23442783},
pmcid = {PMC3599764},
keywords = {Acetaminophen, Adolescent, Adult, Aged, Amines, Amitriptyline, Analgesics, Non-Narcotic, Analgesics, Opioid, Anticonvulsants, Capsaicin, Child, Child, Preschool, Codeine, Cyclohexanecarboxylic Acids, Diabetic Neuropathies, Drug Combinations, Drug Prescriptions, Female, Great Britain, Humans, Hydrocodone, Infant, Male, Middle Aged, Neuralgia, Postherpetic, Phantom Limb, Physician's Practice Patterns, Primary Health Care, Sensory System Agents, Young Adult, gamma-Aminobutyric Acid, incidence},
pages = {28}
}Ultrasound-guided neuronavigation improves safety of ventricular catheter insertion in preterm infants. Heussinger, N., Eyüpoglu, Y, I., Ganslandt, O., Finzel, S., Trollmann, R., & Jüngert, J. Brain \& development, 35(10):905--11, November, 2013.
Paper doi abstract bibtex
Paper doi abstract bibtex BACKGROUND: Intra-ventricular hemorrhage (IVH) is a frequent cause of shunt-dependent hydrocephalus. The management of IVH in preterm babies remains a challenge both for neonatologists and pediatric neurosurgeons, compounded by the lack of low-risk, validated therapy techniques. OBJECTIVE: The aim of this study was to evaluate the feasibility and safety of a novel technique involving the ultrasound-guided placement of a central catheter connected with a Rickham-Capsule in a cohort of preterm, low-birth-weight babies with post-hemorrhagic hydrocephalus (PHH). METHODS: Eight preterm infants with PHH in which a Rickham-Capsule was placed from 2008-2012 were included. Conventional surgical techniques were used in four preterm infants; whereas in the other four preterm babies ultrasound guided catheter placement was performed with an 8 MegaHertz (MHz) micro convex transducer from LOGIQ 9, GE Healthcare; whereby the anterior fontanel was used as an acoustic window. RESULTS: Overall gestational age was 24-31 weeks, mean age at operation was 20.1 (7-36) days, mean birth weight 972.5±370 g, mean weight at first surgical intervention 1023.75±400.4 g. Six patients had bilateral IVH II-III°, two patients had parenchymal involvement. Using the conventional approach, incorrect catheter placement occurred in one of four patients below 1000 g, whereas none of the ultrasound guided cases needed correction. CONCLUSIONS: Ultrasound-guided neuronavigation represents a relevant tool in the treatment of hydrocephalus in preterm infants through increased accuracy in placement of a central catheter connected to a Rickham-Capsule. The benefit of utilizing this form of neuronavigation needs to be assessed through corresponding standardized studies.
@article{ heussinger_ultrasound-guided_2013,
title = {Ultrasound-guided neuronavigation improves safety of ventricular catheter insertion in preterm infants.},
volume = {35},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23265618},
doi = {10.1016/j.braindev.2012.11.008},
abstract = {BACKGROUND: Intra-ventricular hemorrhage (IVH) is a frequent cause of shunt-dependent hydrocephalus. The management of IVH in preterm babies remains a challenge both for neonatologists and pediatric neurosurgeons, compounded by the lack of low-risk, validated therapy techniques.
OBJECTIVE: The aim of this study was to evaluate the feasibility and safety of a novel technique involving the ultrasound-guided placement of a central catheter connected with a Rickham-Capsule in a cohort of preterm, low-birth-weight babies with post-hemorrhagic hydrocephalus (PHH).
METHODS: Eight preterm infants with PHH in which a Rickham-Capsule was placed from 2008-2012 were included. Conventional surgical techniques were used in four preterm infants; whereas in the other four preterm babies ultrasound guided catheter placement was performed with an 8 MegaHertz (MHz) micro convex transducer from LOGIQ 9, GE Healthcare; whereby the anterior fontanel was used as an acoustic window.
RESULTS: Overall gestational age was 24-31 weeks, mean age at operation was 20.1 (7-36) days, mean birth weight 972.5±370 g, mean weight at first surgical intervention 1023.75±400.4 g. Six patients had bilateral IVH II-III°, two patients had parenchymal involvement. Using the conventional approach, incorrect catheter placement occurred in one of four patients below 1000 g, whereas none of the ultrasound guided cases needed correction.
CONCLUSIONS: Ultrasound-guided neuronavigation represents a relevant tool in the treatment of hydrocephalus in preterm infants through increased accuracy in placement of a central catheter connected to a Rickham-Capsule. The benefit of utilizing this form of neuronavigation needs to be assessed through corresponding standardized studies.},
number = {10},
journal = {Brain \& development},
author = {Heussinger, Nicole and Eyüpoglu, Ilker Y and Ganslandt, Oliver and Finzel, Stephanie and Trollmann, Regina and Jüngert, Jörg},
month = {November},
year = {2013},
keywords = {Catheterization, Catheterization: methods, Cerebral Hemorrhage, Cerebral Hemorrhage: complications, Cerebral Ventricles, Cerebral Ventricles: surgery, Cerebral Ventricles: ultrasonography, Female, Humans, Hydrocephalus, Hydrocephalus: surgery, Hydrocephalus: ultrasonography, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Infant, Premature, Diseases: surgery, Infant, Premature, Diseases: ultrasonography, Male, Neuronavigation, Neuronavigation: methods, Retrospective Studies, Ultrasonography, Interventional, Ultrasonography, Interventional: methods, Ventriculoperitoneal Shunt},
pages = {905--11}
}Multimodality imaging of vascular anomalies. Restrepo, R. Pediatric Radiology, 43 Suppl 1:S141--154, March, 2013. 00009
doi abstract bibtex
doi abstract bibtex
Vascular malformations and hemangiomas are common in children but remain a source of confusion during diagnosis, in part because of the lack of a uniform terminology. With the existing treatments for hemangiomas and vascular malformations, it is important to make the correct diagnosis initially to prevent adverse physical and emotional sequelae in not only the child but also the family. The diagnosis of vascular malformations is made primarily by the clinician and based on the physical exam. Imaging is carried out using predominantly ultrasound (US) and magnetic resonance imaging (MRI), which are complementary modalities. In most cases of vascular anomalies, US is the first line of imaging as it is readily available, less expensive, lacks ionizing radiation and does not require sedation. MRI is also of great help for further characterizing the lesions. Conventional arteriography is reserved for cases that require therapeutic intervention, more commonly for arteriovenous malformations. Radiographs usually play no role in diagnosing vascular anomalies in children. In this article, the author describes the terminology and types of hemangiomas and vascular malformations and their clinical, histological features, as well as the imaging approach and appearance.
@article{restrepo_multimodality_2013,
title = {Multimodality imaging of vascular anomalies},
volume = {43 Suppl 1},
issn = {1432-1998},
doi = {10.1007/s00247-012-2584-y},
abstract = {Vascular malformations and hemangiomas are common in children but remain a source of confusion during diagnosis, in part because of the lack of a uniform terminology. With the existing treatments for hemangiomas and vascular malformations, it is important to make the correct diagnosis initially to prevent adverse physical and emotional sequelae in not only the child but also the family. The diagnosis of vascular malformations is made primarily by the clinician and based on the physical exam. Imaging is carried out using predominantly ultrasound (US) and magnetic resonance imaging (MRI), which are complementary modalities. In most cases of vascular anomalies, US is the first line of imaging as it is readily available, less expensive, lacks ionizing radiation and does not require sedation. MRI is also of great help for further characterizing the lesions. Conventional arteriography is reserved for cases that require therapeutic intervention, more commonly for arteriovenous malformations. Radiographs usually play no role in diagnosing vascular anomalies in children. In this article, the author describes the terminology and types of hemangiomas and vascular malformations and their clinical, histological features, as well as the imaging approach and appearance.},
language = {eng},
journal = {Pediatric Radiology},
author = {Restrepo, Ricardo},
month = mar,
year = {2013},
pmid = {23478930},
note = {00009 },
keywords = {Child, Child, Preschool, Diagnosis, Differential, Female, Hemangioma, Humans, Infant, Infant, Newborn, Magnetic Resonance Angiography, Male, Subtraction Technique, ultrasonography, vascular malformations},
pages = {S141--154}
}Cancer diagnosed by emergency admission in England: an observational study using the general practice research database. Tsang, C., Bottle, A., Majeed, A., & Aylin, P. BMC health services research, 13:308, 2013.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Patients diagnosed with cancer by the emergency route often have more advanced diseases and poorer outcomes. Rates of cancer diagnosed through unplanned admissions vary within and between countries, suggesting potential inconsistencies in the quality of care. To reduce diagnoses by this route and improve patient outcomes, high risk patient groups must be identified. This cross-sectional observational study determined the incidence of first-ever diagnoses of cancer by emergency (unplanned) admission and identified patient-level risk factors for these diagnoses in England. METHODS: Data for 74,763 randomly selected patients at 457 general practices between 1999 and 2008 were obtained from the General Practice Research Database (GPRD), including integrated Hospital Episode Statistics (HES) data and Office for National Statistics (ONS) mortality data. The proportion of first-ever diagnoses by emergency admission out of all recorded first cancer diagnoses by any route was analysed by patient characteristics. RESULTS: Diagnosis by emergency admission was recorded in 13.9% of patients diagnosed with cancer for the first time (n = 817/5870). The incidence of first cases by the emergency route was 2.51 patients per 10,000 person years. In adjusted regression analyses, patients of older age (p \textless 0.0001), living in the most deprived areas (RR 1.93, 95% CI 1.51 to 2.47; p \textless 0.0001) or who had a total Charlson score of 1 compared to 0 (RR 1.34, 95% CI 1.06 to 1.69; p = 0.014) were most at risk of diagnosis by emergency admission. Patients with more prior (all-cause) emergency admissions were less at risk of subsequent diagnosis by the emergency route (RR 0.31 per prior emergency admission, 95% CI 0.20 to 0.46; p \textless 0.0001). CONCLUSIONS: A much lower incidence of first-ever cancer diagnoses by emergency admission was found compared with previous studies. Identified high risk groups may benefit from interventions to reduce delayed diagnosis. Further studies should include screening and cancer staging data to improve understanding of delayed or untimely diagnosis and patient care pathways.
@article{tsang_cancer_2013,
title = {Cancer diagnosed by emergency admission in {England}: an observational study using the general practice research database},
volume = {13},
issn = {1472-6963},
shorttitle = {Cancer diagnosed by emergency admission in {England}},
doi = {10.1186/1472-6963-13-308},
abstract = {BACKGROUND: Patients diagnosed with cancer by the emergency route often have more advanced diseases and poorer outcomes. Rates of cancer diagnosed through unplanned admissions vary within and between countries, suggesting potential inconsistencies in the quality of care. To reduce diagnoses by this route and improve patient outcomes, high risk patient groups must be identified. This cross-sectional observational study determined the incidence of first-ever diagnoses of cancer by emergency (unplanned) admission and identified patient-level risk factors for these diagnoses in England.
METHODS: Data for 74,763 randomly selected patients at 457 general practices between 1999 and 2008 were obtained from the General Practice Research Database (GPRD), including integrated Hospital Episode Statistics (HES) data and Office for National Statistics (ONS) mortality data. The proportion of first-ever diagnoses by emergency admission out of all recorded first cancer diagnoses by any route was analysed by patient characteristics.
RESULTS: Diagnosis by emergency admission was recorded in 13.9\% of patients diagnosed with cancer for the first time (n = 817/5870). The incidence of first cases by the emergency route was 2.51 patients per 10,000 person years. In adjusted regression analyses, patients of older age (p {\textless} 0.0001), living in the most deprived areas (RR 1.93, 95\% CI 1.51 to 2.47; p {\textless} 0.0001) or who had a total Charlson score of 1 compared to 0 (RR 1.34, 95\% CI 1.06 to 1.69; p = 0.014) were most at risk of diagnosis by emergency admission. Patients with more prior (all-cause) emergency admissions were less at risk of subsequent diagnosis by the emergency route (RR 0.31 per prior emergency admission, 95\% CI 0.20 to 0.46; p {\textless} 0.0001).
CONCLUSIONS: A much lower incidence of first-ever cancer diagnoses by emergency admission was found compared with previous studies. Identified high risk groups may benefit from interventions to reduce delayed diagnosis. Further studies should include screening and cancer staging data to improve understanding of delayed or untimely diagnosis and patient care pathways.},
language = {eng},
journal = {BMC health services research},
author = {Tsang, Carmen and Bottle, Alex and Majeed, Azeem and Aylin, Paul},
year = {2013},
pmid = {23941140},
pmcid = {PMC3751722},
keywords = {Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Confidence Intervals, Cross-Sectional Studies, Databases, Factual, Emergency Service, Hospital, England, Female, General Practice, Humans, Infant, Male, Medical Audit, Middle Aged, Neoplasms, Patient Admission, Poisson Distribution, Qualitative Research, Risk Factors, Young Adult},
pages = {308}
}Genitourinary rhabdomyosarcoma: unusual diagnosis presenting within hours of delivery. Marietti, S., Saenz, N., Willert, J., & Holmes, N. Journal of Pediatric Urology, 9(4):e139--143, August, 2013.
doi abstract bibtex
doi abstract bibtex
Genitourinary rhabdomyosarcoma of the newborn is extremely rare. We present a case report of a newborn delivered with a palpable abdominal mass revealing rhabdomyosarcoma on biopsy. Prenatal care was normal. The child was treated with multimodal therapy including extensive chemotherapy, surgical excision, and radiation therapy. Surgical excision included cystoprostatectomy, ureterostomy, abdominoperineal resection and colostomy placement. He continued to progress and eventually succumbed to his disease.
@article{marietti_genitourinary_2013,
title = {Genitourinary rhabdomyosarcoma: unusual diagnosis presenting within hours of delivery},
volume = {9},
issn = {1873-4898},
shorttitle = {Genitourinary rhabdomyosarcoma},
doi = {10.1016/j.jpurol.2013.02.010},
abstract = {Genitourinary rhabdomyosarcoma of the newborn is extremely rare. We present a case report of a newborn delivered with a palpable abdominal mass revealing rhabdomyosarcoma on biopsy. Prenatal care was normal. The child was treated with multimodal therapy including extensive chemotherapy, surgical excision, and radiation therapy. Surgical excision included cystoprostatectomy, ureterostomy, abdominoperineal resection and colostomy placement. He continued to progress and eventually succumbed to his disease.},
language = {eng},
number = {4},
journal = {Journal of Pediatric Urology},
author = {Marietti, Sarah and Saenz, Nicholas and Willert, Jennifer and Holmes, Nicholas},
month = aug,
year = {2013},
pmid = {23510697},
keywords = {Biopsy, Fatal Outcome, Humans, Infant, Newborn, Magnetic Resonance Imaging, Male, Neonatal Screening, Rhabdomyosarcoma, Time Factors, Tomography, X-Ray Computed, Urogenital Neoplasms},
pages = {e139--143}
}Antimalarial chemoprophylaxis and the risk of neuropsychiatric disorders. Schneider, C., Adamcova, M., Jick, S. S., Schlagenhauf, P., Miller, M. K., Rhein, H., & Meier, C. R. Travel Medicine and Infectious Disease, 11(2):71--80, April, 2013.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Case reports and epidemiological studies have associated the use of mefloquine with neuropsychiatric adverse events. METHODS: We used the General Practice Research Database to conduct a follow-up study with a nested case-control analysis. We assessed the risk of developing first-time anxiety, stress-related disorders/psychosis, depression, epilepsy or peripheral neuropathies in patients using mefloquine, chloroquine and/or proguanil, or atovaquone/proguanil for malaria chemoprophylaxis, as compared to unexposed travelers. RESULTS: Compared to non-users of antimalarials, the adjusted odds ratio in the nested case-control analysis for users of mefloquine, chloroquine and/or proguanil, or atovaquone/proguanil were 0.71 (95% CI 0.56-0.90), 1.04 (95% CI 0.74-1.46), and 0.73 (95% CI 0.61-0.86) for anxiety or stress-related disorders combined, 0.54 (95% CI 0.41-0.71), 1.06 (95% CI 0.71-1.59), and 0.75 (95% CI 0.62-0.91) for depression, 0.69 (95% CI 0.35-1.36), 1.41 (95% CI 0.54-3.67), and 0.75 (95% CI 0.42-1.36) for epilepsy, and 1.22 (95% CI 0.50-2.99), 1.59 (95% CI 0.41-6.15), and 1.05 (95% CI 0.54-2.03) for neuropathies, respectively. The risk of all outcomes was higher in females than in males across all exposure categories. CONCLUSIONS: The risk of neuropsychiatric disorders was similar for users and for non-users of anti-malarial chemoprophylaxis, with evidence for elevated risks in some subgroups.
@article{schneider_antimalarial_2013,
title = {Antimalarial chemoprophylaxis and the risk of neuropsychiatric disorders},
volume = {11},
issn = {1873-0442},
doi = {10.1016/j.tmaid.2013.02.008},
abstract = {BACKGROUND: Case reports and epidemiological studies have associated the use of mefloquine with neuropsychiatric adverse events.
METHODS: We used the General Practice Research Database to conduct a follow-up study with a nested case-control analysis. We assessed the risk of developing first-time anxiety, stress-related disorders/psychosis, depression, epilepsy or peripheral neuropathies in patients using mefloquine, chloroquine and/or proguanil, or atovaquone/proguanil for malaria chemoprophylaxis, as compared to unexposed travelers.
RESULTS: Compared to non-users of antimalarials, the adjusted odds ratio in the nested case-control analysis for users of mefloquine, chloroquine and/or proguanil, or atovaquone/proguanil were 0.71 (95\% CI 0.56-0.90), 1.04 (95\% CI 0.74-1.46), and 0.73 (95\% CI 0.61-0.86) for anxiety or stress-related disorders combined, 0.54 (95\% CI 0.41-0.71), 1.06 (95\% CI 0.71-1.59), and 0.75 (95\% CI 0.62-0.91) for depression, 0.69 (95\% CI 0.35-1.36), 1.41 (95\% CI 0.54-3.67), and 0.75 (95\% CI 0.42-1.36) for epilepsy, and 1.22 (95\% CI 0.50-2.99), 1.59 (95\% CI 0.41-6.15), and 1.05 (95\% CI 0.54-2.03) for neuropathies, respectively. The risk of all outcomes was higher in females than in males across all exposure categories.
CONCLUSIONS: The risk of neuropsychiatric disorders was similar for users and for non-users of anti-malarial chemoprophylaxis, with evidence for elevated risks in some subgroups.},
language = {eng},
number = {2},
journal = {Travel Medicine and Infectious Disease},
author = {Schneider, Cornelia and Adamcova, Miriam and Jick, Susan S. and Schlagenhauf, Patricia and Miller, Mary K. and Rhein, Hans-Georg and Meier, Christoph R.},
month = apr,
year = {2013},
pmid = {23541791},
keywords = {Adolescent, Adult, Aged, Antimalarials, Chemoprevention, Child, Child, Preschool, Female, Great Britain, Humans, Infant, Malaria, Male, Mental Disorders, Middle Aged, Odds Ratio, Risk, Travel, incidence},
pages = {71--80}
}The validation and utility of a quantitative one-step multiplex RT real-time PCR targeting rotavirus A and norovirus. Dung, T. T. N., Phat, V. V., Nga, T. V. T., My, P. V. T., Duy, P. T., Campbell, J. I., Thuy, C. T., Hoang, N. V. M., Van Minh, P., Le Phuc, H., Tuyet, P. T. N., Vinh, H., Kien, D. T. H., Huy, H. L. A., Vinh, N. T., Nga, T. T. T., Hau, N. T. T., Chinh, N. T., Thuong, T. C., Tuan, H. M., Simmons, C., Farrar, J. J., & Baker, S. Journal of virological methods, 187(1):138–143, January, 2013.
doi abstract bibtex
doi abstract bibtex
Rotavirus (RoV) and Norovirus (NoV) are the main causes of viral gastroenteritis. Currently, there is no validated multiplex real-time PCR that can detect and quantify RoV and NoV simultaneously. The aim of the study was to develop, validate, and internally control a multiplex one-step RT real-time PCR to detect and quantify RoV and NoV in stool samples. PCR sensitivity was assessed by comparing amplification against the current gold standard, enzyme immunoassay (EIA), on stool samples from 94 individuals with diarrhea and 94 individuals without diarrhea. PCR detected 10% more RoV positive samples than EIA in stools samples from patients with diarrhea. PCR detected 23% more NoV genogroup II positive samples from individuals with diarrhea and 9% more from individuals without diarrhea than EIA, respectively. Genotyping of the PCR positive/EIA negative samples suggested the higher rate of PCR positivity, in comparison to EIA, was due to increased sensitivity, rather than nonspecific hybridization. Quantitation demonstrated that the viral loads of RoV and NoV in the stools of diarrheal patients were an order of magnitude greater than in individuals without diarrhea. This internally controlled real-time PCR method is robust, exhibits a high degree of reproducibility, and may have a greater utility and sensitivity than commercial EIA kits.
@article{dung_validation_2013,
title = {The validation and utility of a quantitative one-step multiplex {RT} real-time {PCR} targeting rotavirus {A} and norovirus.},
volume = {187},
copyright = {Copyright (c) 2012 Elsevier B.V. All rights reserved.},
issn = {1879-0984 0166-0934},
doi = {10.1016/j.jviromet.2012.09.021},
abstract = {Rotavirus (RoV) and Norovirus (NoV) are the main causes of viral gastroenteritis. Currently, there is no validated multiplex real-time PCR that can detect and quantify RoV and NoV simultaneously. The aim of the study was to develop, validate, and internally control a multiplex one-step RT real-time PCR to detect and quantify RoV and NoV in stool samples. PCR sensitivity was assessed by comparing amplification against the current gold standard, enzyme immunoassay (EIA), on stool samples from 94 individuals with diarrhea and 94 individuals without diarrhea. PCR detected 10\% more RoV positive samples than EIA in stools samples from patients with diarrhea. PCR detected 23\% more NoV genogroup II positive samples from individuals with diarrhea and 9\% more from individuals without diarrhea than EIA, respectively. Genotyping of the PCR positive/EIA negative samples suggested the higher rate of PCR positivity, in comparison to EIA, was due to increased sensitivity, rather than nonspecific hybridization. Quantitation demonstrated that the viral loads of RoV and NoV in the stools of diarrheal patients were an order of magnitude greater than in individuals without diarrhea. This internally controlled real-time PCR method is robust, exhibits a high degree of reproducibility, and may have a greater utility and sensitivity than commercial EIA kits.},
language = {eng},
number = {1},
journal = {Journal of virological methods},
author = {Dung, Tran Thi Ngoc and Phat, Voong Vinh and Nga, Tran Vu Thieu and My, Phan Vu Tra and Duy, Pham Thanh and Campbell, James I. and Thuy, Cao Thu and Hoang, Nguyen Van Minh and Van Minh, Pham and Le Phuc, Hoang and Tuyet, Pham Thi Ngoc and Vinh, Ha and Kien, Duong Thi Hue and Huy, Huynh Le Anh and Vinh, Nguyen Thanh and Nga, Tran Thi Thu and Hau, Nguyen Thi Thu and Chinh, Nguyen Tran and Thuong, Tang Chi and Tuan, Ha Manh and Simmons, Cameron and Farrar, Jeremy J. and Baker, Stephen},
month = jan,
year = {2013},
pmid = {23046990},
pmcid = {PMC3528950},
keywords = {*Multiplex Polymerase Chain Reaction, *Real-Time Polymerase Chain Reaction, Caliciviridae Infections/*diagnosis/virology, Child, Preschool, Diarrhea/diagnosis/virology, Feces/virology, Gastroenteritis/diagnosis/genetics, Genotype, Humans, Infant, Infant, Newborn, Norovirus/genetics/*isolation \& purification, RNA, Viral/analysis, Reproducibility of Results, Reverse Transcriptase Polymerase Chain Reaction, Rotavirus Infections/*diagnosis/virology, Rotavirus/genetics/*isolation \& purification},
pages = {138--143},
}2012 (8)
A study on the epidemiology of rosacea in the U.K. Spoendlin, J., Voegel, J. J., Jick, S. S., & Meier, C. R. The British Journal of Dermatology, 167(3):598--605, September, 2012.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09% to 22%. To our knowledge, incidence rates have not been quantified before. OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls. METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region. RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase. CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.
@article{spoendlin_study_2012,
title = {A study on the epidemiology of rosacea in the {U}.{K}},
volume = {167},
issn = {1365-2133},
doi = {10.1111/j.1365-2133.2012.11037.x},
abstract = {BACKGROUND: Rosacea is a chronic facial skin disease of unclear origin. Epidemiological data are scarce and controversial, with reported prevalences ranging from 0·09\% to 22\%. To our knowledge, incidence rates have not been quantified before.
OBJECTIVES: In this observational study we quantified incidence rates of diagnosed rosacea in the U.K. and described demographic characteristics and the prevalence of ocular symptoms in patients with rosacea. We compared lifestyle factors such as smoking and alcohol consumption between patients with rosacea and controls.
METHODS: Using the U.K.-based General Practice Research Database, we identified patients with an incident diagnosis of rosacea between 1995 and 2009 and matched them (1:1) to rosacea-free control patients. We assessed person-time of all patients at risk and assessed incidence rates of rosacea, stratified by age, sex, year of diagnosis and region.
RESULTS: We identified 60,042 rosacea cases and 60,042 controls (61·5\% women). The overall incidence rate for diagnosed rosacea in the U.K. was 1·65 per 1000 person-years. Rosacea was diagnosed in some 80\% of cases after the age of 30 years. Ocular symptoms were recorded in 20·8\% of cases at the index date. We observed a significantly reduced relative risk of developing rosacea among current smokers (odds ratio 0·64, 95\% confidence interval 0·62-0·67). Alcohol consumption was associated with a marginal risk increase.
CONCLUSIONS: We quantified incidence rates and characteristics of patients with rosacea diagnosed in clinical practice in a large epidemiological study using primary care data from the U.K. Smoking was associated with a substantially reduced risk of developing rosacea.},
language = {eng},
number = {3},
journal = {The British Journal of Dermatology},
author = {Spoendlin, J. and Voegel, J. J. and Jick, S. S. and Meier, C. R.},
month = sep,
year = {2012},
pmid = {22564022},
keywords = {Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Alcohol Drinking, Child, Child, Preschool, Diagnosis, Differential, Epidemiologic Methods, Female, Great Britain, Humans, Infant, Life Style, Male, Middle Aged, Rosacea, Smoking, Young Adult, incidence},
pages = {598--605}
}Proton therapy for spinal ependymomas: planning, acute toxicities, and preliminary outcomes. Amsbaugh, M., J., Grosshans, D., R., McAleer, M., F., Zhu, R., Wages, C., Crawford, C., N., Palmer, M., De Gracia, B., Woo, S., & Mahajan, A. International Journal of Radiation Oncology Biology Physics, 83(5):1419-24, Elsevier Inc, 8, 2012.
Paper abstract bibtex
Paper abstract bibtex PURPOSE: To report acute toxicities and preliminary outcomes for pediatric patients with ependymomas of the spine treated with proton beam therapy at the MD Anderson Cancer Center.
METHODS AND MATERIALS: Eight pediatric patients received proton beam irradiation between October 2006 and September 2010 for spinal ependymomas. Toxicity data were collected weekly during radiation therapy and all follow-up visits. Toxicities were graded according to the Common Terminology Criteria for Adverse Events version 3.0.
RESULTS: All patients had surgical resection of the tumor before irradiation (7 subtotal resection and 1 gross total resection). Six patients had World Health Organization Grade I ependymomas, and two had World Health Organization Grade II ependymomas. Patients had up to 3 surgical interventions before radiation therapy (range, 1-3; median, 1). Three patients received proton therapy after recurrence and five as part of their primary management. The entire vertebral body was treated in all but 2 patients. The mean radiation dose was 51.1 cobalt gray equivalents (range, 45 to 54 cobalt gray equivalents). With a mean follow-up of 26 months from the radiation therapy start date (range, 7-51 months), local control, event-free survival, and overall survival rates were all 100%. The most common toxicities during treatment were Grade 1 or 2 erythema (75%) and Grade 1 fatigue (38%). No patients had a Grade 3 or higher adverse event. Proton therapy dramatically reduced dose to all normal tissues anterior to the vertebral bodies in comparison to photon therapy.
CONCLUSION: Preliminary outcomes show the expected control rates with favorable acute toxicity profiles. Proton beam therapy offers a powerful treatment option in the pediatric population, where adverse events related to radiation exposure are of concern. Extended follow-up will be required to assess for late recurrences and long-term adverse effects.
@article{
title = {Proton therapy for spinal ependymomas: planning, acute toxicities, and preliminary outcomes.},
type = {article},
year = {2012},
identifiers = {[object Object]},
keywords = {Adolescent,Child,Child, Preschool,Disease-Free Survival,Ependymoma,Ependymoma: pathology,Ependymoma: radiotherapy,Ependymoma: surgery,Erythema,Erythema: etiology,Erythema: pathology,Fatigue,Fatigue: etiology,Female,Follow-Up Studies,Humans,Infant,Male,Neoplasm Recurrence, Local,Neoplasm Recurrence, Local: radiotherapy,Protons,Protons: adverse effects,Protons: therapeutic use,Radiation Injuries,Radiotherapy Dosage,Spinal Neoplasms,Spinal Neoplasms: pathology,Spinal Neoplasms: radiotherapy,Spinal Neoplasms: surgery,Survival Rate,Treatment Outcome,Tumor Burden},
pages = {1419-24},
volume = {83},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/22245209},
month = {8},
publisher = {Elsevier Inc},
day = {1},
id = {ba888ca5-70c7-39d5-946d-244183b6d8d3},
created = {2014-03-15T18:24:10.000Z},
accessed = {2014-03-04},
file_attached = {true},
profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
last_modified = {2014-12-29T19:36:51.000Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
abstract = {PURPOSE: To report acute toxicities and preliminary outcomes for pediatric patients with ependymomas of the spine treated with proton beam therapy at the MD Anderson Cancer Center.
METHODS AND MATERIALS: Eight pediatric patients received proton beam irradiation between October 2006 and September 2010 for spinal ependymomas. Toxicity data were collected weekly during radiation therapy and all follow-up visits. Toxicities were graded according to the Common Terminology Criteria for Adverse Events version 3.0.
RESULTS: All patients had surgical resection of the tumor before irradiation (7 subtotal resection and 1 gross total resection). Six patients had World Health Organization Grade I ependymomas, and two had World Health Organization Grade II ependymomas. Patients had up to 3 surgical interventions before radiation therapy (range, 1-3; median, 1). Three patients received proton therapy after recurrence and five as part of their primary management. The entire vertebral body was treated in all but 2 patients. The mean radiation dose was 51.1 cobalt gray equivalents (range, 45 to 54 cobalt gray equivalents). With a mean follow-up of 26 months from the radiation therapy start date (range, 7-51 months), local control, event-free survival, and overall survival rates were all 100%. The most common toxicities during treatment were Grade 1 or 2 erythema (75%) and Grade 1 fatigue (38%). No patients had a Grade 3 or higher adverse event. Proton therapy dramatically reduced dose to all normal tissues anterior to the vertebral bodies in comparison to photon therapy.
CONCLUSION: Preliminary outcomes show the expected control rates with favorable acute toxicity profiles. Proton beam therapy offers a powerful treatment option in the pediatric population, where adverse events related to radiation exposure are of concern. Extended follow-up will be required to assess for late recurrences and long-term adverse effects.},
bibtype = {article},
author = {Amsbaugh, Mark J and Grosshans, David R and McAleer, Mary Frances and Zhu, Ron and Wages, Cody and Crawford, Cody N and Palmer, Matthew and De Gracia, Beth and Woo, Shiao and Mahajan, Anita},
journal = {International Journal of Radiation Oncology Biology Physics},
number = {5}
}Neurodevelopmental outcomes in infants requiring resuscitation in developing countries. Carlo W.A., Goudar S.S., Pasha O., Chomba E., McClure E.M., Biasini F.J., Wallander J.L., Thorsten V., Chakraborty H., & Wright L.L. 2012.
abstract bibtex
abstract bibtex
OBJECTIVE: To determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment., STUDY DESIGN: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported., RESULTS: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index \textless85 on the Bayley Scales of Infant Development-II (primary outcome; 18% versus 12%; P = .22) and in other neurodevelopmental outcomes., CONCLUSIONS: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments. Copyright © 2012 Mosby, Inc. All rights reserved.
@misc{carlo_w.a._neurodevelopmental_2012,
title = {Neurodevelopmental outcomes in infants requiring resuscitation in developing countries},
abstract = {OBJECTIVE: To determine whether resuscitation of infants who failed to develop effective breathing at birth increases survivors with neurodevelopmental impairment., STUDY DESIGN: Infants unresponsive to stimulation who received bag and mask ventilation at birth in a resuscitation trial and infants who did not require any resuscitation were randomized to early neurodevelopmental intervention or control groups. Infants were examined by trained neurodevelopmental evaluators masked to both their resuscitation history and intervention group. The 12-month neurodevelopmental outcome data for both resuscitated and non-resuscitated infants randomized to the control groups are reported., RESULTS: The study provided no evidence of a difference between the resuscitated infants (n = 86) and the non-resuscitated infants (n = 115) in the percentage of infants at 12 months with a Mental Developmental Index {\textless}85 on the Bayley Scales of Infant Development-II (primary outcome; 18\% versus 12\%; P = .22) and in other neurodevelopmental outcomes., CONCLUSIONS: Most infants who received resuscitation with bag and mask ventilation at birth have 12-month neurodevelopmental outcomes in the reference range. Longer follow-up is needed because of increased risk for neurodevelopmental impairments. Copyright © 2012 Mosby, Inc. All rights reserved.},
journal = {The Journal of pediatrics},
author = {{Carlo W.A.} and {Goudar S.S.} and {Pasha O.} and {Chomba E.} and {McClure E.M.} and {Biasini F.J.} and {Wallander J.L.} and {Thorsten V.} and {Chakraborty H.} and {Wright L.L.}},
year = {2012},
keywords = {*adverse effects, *procedures, Developmental Disabilities/di [Diagnosis], Developmental Disabilities/ep [Epidemiology], India, Learning Disorders/di [Diagnosis], Learning Disorders/ep [Epidemiology], Mental Disorders/di [Diagnosis], Mental Disorders/ep [Epidemiology], Pakistan, Respiratory Distress Syndrome, Newborn/th [Therapy], Zambia, child development, clinical trial, comparative study, controlled study, developing country, female, human, incidence, infant, male, multicenter study, neuropsychological test, newborn, physiology, prematurity, randomized controlled trial, reference value, resuscitation, risk assessment, rural population, severity of illness index, survival analysis, very low birth weight}
}Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., Abraham, J., Ackerman, I., Aggarwal, R., Ahn, S. Y., Ali, M. K., Alvarado, M., Anderson, H. R., Anderson, L. M., Andrews, K. G., Atkinson, C., Baddour, L. M., Bahalim, A. N., Barker-Collo, S., Barrero, L. H., Bartels, D. H., Basáñez, M., Baxter, A., Bell, M. L., Benjamin, E. J., Bennett, D., Bernabé, E., Bhalla, K., Bhandari, B., Bikbov, B., Bin Abdulhak, A., Birbeck, G., Black, J. A., Blencowe, H., Blore, J. D., Blyth, F., Bolliger, I., Bonaventure, A., Boufous, S., Bourne, R., Boussinesq, M., Braithwaite, T., Brayne, C., Bridgett, L., Brooker, S., Brooks, P., Brugha, T. S., Bryan-Hancock, C., Bucello, C., Buchbinder, R., Buckle, G., Budke, C. M., Burch, M., Burney, P., Burstein, R., Calabria, B., Campbell, B., Canter, C. E., Carabin, H., Carapetis, J., Carmona, L., Cella, C., Charlson, F., Chen, H., Cheng, A. T., Chou, D., Chugh, S. S., Coffeng, L. E., Colan, S. D., Colquhoun, S., Colson, K. E., Condon, J., Connor, M. D., Cooper, L. T., Corriere, M., Cortinovis, M., de Vaccaro, K. C., Couser, W., Cowie, B. C., Criqui, M. H., Cross, M., Dabhadkar, K. C., Dahiya, M., Dahodwala, N., Damsere-Derry, J., Danaei, G., Davis, A., De Leo, D., Degenhardt, L., Dellavalle, R., Delossantos, A., Denenberg, J., Derrett, S., Des Jarlais, D. C., Dharmaratne, S. D., Dherani, M., Diaz-Torne, C., Dolk, H., Dorsey, E. R., Driscoll, T., Duber, H., Ebel, B., Edmond, K., Elbaz, A., Ali, S. E., Erskine, H., Erwin, P. J., Espindola, P., Ewoigbokhan, S. E., Farzadfar, F., Feigin, V., Felson, D. T., Ferrari, A., Ferri, C. P., Fèvre, E. M., Finucane, M. M., Flaxman, S., Flood, L., Foreman, K., Forouzanfar, M. H., Fowkes, F. G. R., Franklin, R., Fransen, M., Freeman, M. K., Gabbe, B. J., Gabriel, S. E., Gakidou, E., Ganatra, H. A., Garcia, B., Gaspari, F., Gillum, R. F., Gmel, G., Gosselin, R., Grainger, R., Groeger, J., Guillemin, F., Gunnell, D., Gupta, R., Haagsma, J., Hagan, H., Halasa, Y. A., Hall, W., Haring, D., Haro, J. M., Harrison, J. E., Havmoeller, R., Hay, R. J., Higashi, H., Hill, C., Hoen, B., Hoffman, H., Hotez, P. J., Hoy, D., Huang, J. J., Ibeanusi, S. E., Jacobsen, K. H., James, S. L., Jarvis, D., Jasrasaria, R., Jayaraman, S., Johns, N., Jonas, J. B., Karthikeyan, G., Kassebaum, N., Kawakami, N., Keren, A., Khoo, J., King, C. H., Knowlton, L. M., Kobusingye, O., Koranteng, A., Krishnamurthi, R., Lalloo, R., Laslett, L. L., Lathlean, T., Leasher, J. L., Lee, Y. Y., Leigh, J., Lim, S. S., Limb, E., Lin, J. K., Lipnick, M., Lipshultz, S. E., Liu, W., Loane, M., Ohno, S. L., Lyons, R., Ma, J., Mabweijano, J., MacIntyre, M. F., Malekzadeh, R., Mallinger, L., Manivannan, S., Marcenes, W., March, L., Margolis, D. J., Marks, G. B., Marks, R., Matsumori, A., Matzopoulos, R., Mayosi, B. M., McAnulty, J. H., McDermott, M. M., McGill, N., McGrath, J., Medina-Mora, M. E., Meltzer, M., Mensah, G. A., Merriman, T. R., Meyer, A., Miglioli, V., Miller, M., Miller, T. R., Mitchell, P. B., Mocumbi, A. O., Moffitt, T. E., Mokdad, A. A., Monasta, L., Montico, M., Moradi-Lakeh, M., Moran, A., Morawska, L., Mori, R., Murdoch, M. E., Mwaniki, M. K., Naidoo, K., Nair, M. N., Naldi, L., Narayan, K. M. V., Nelson, P. K., Nelson, R. G., Nevitt, M. C., Newton, C. R., Nolte, S., Norman, P., Norman, R., O'Donnell, M., O'Hanlon, S., Olives, C., Omer, S. B., Ortblad, K., Osborne, R., Ozgediz, D., Page, A., Pahari, B., Pandian, J. D., Rivero, A. P., Patten, S. B., Pearce, N., Padilla, R. P., Perez-Ruiz, F., Perico, N., Pesudovs, K., Phillips, D., Phillips, M. R., Pierce, K., Pion, S., Polanczyk, G. V., Polinder, S., Pope, C. A., Popova, S., Porrini, E., Pourmalek, F., Prince, M., Pullan, R. L., Ramaiah, K. D., Ranganathan, D., Razavi, H., Regan, M., Rehm, J. T., Rein, D. B., Remuzzi, G., Richardson, K., Rivara, F. P., Roberts, T., Robinson, C., De Leòn, F. R., Ronfani, L., Room, R., Rosenfeld, L. C., Rushton, L., Sacco, R. L., Saha, S., Sampson, U., Sanchez-Riera, L., Sanman, E., Schwebel, D. C., Scott, J. G., Segui-Gomez, M., Shahraz, S., Shepard, D. S., Shin, H., Shivakoti, R., Singh, D., Singh, G. M., Singh, J. A., Singleton, J., Sleet, D. A., Sliwa, K., Smith, E., Smith, J. L., Stapelberg, N. J. C., Steer, A., Steiner, T., Stolk, W. A., Stovner, L. J., Sudfeld, C., Syed, S., Tamburlini, G., Tavakkoli, M., Taylor, H. R., Taylor, J. A., Taylor, W. J., Thomas, B., Thomson, W. M., Thurston, G. D., Tleyjeh, I. M., Tonelli, M., Towbin, J. A., Truelsen, T., Tsilimbaris, M. K., Ubeda, C., Undurraga, E. A., van der Werf, M. J., van Os, J., Vavilala, M. S., Venketasubramanian, N., Wang, M., Wang, W., Watt, K., Weatherall, D. J., Weinstock, M. A., Weintraub, R., Weisskopf, M. G., Weissman, M. M., White, R. A., Whiteford, H., Wiersma, S. T., Wilkinson, J. D., Williams, H. C., Williams, S. R. M., Witt, E., Wolfe, F., Woolf, A. D., Wulf, S., Yeh, P., Zaidi, A. K. M., Zheng, Z., Zonies, D., Lopez, A. D., Murray, C. J. L., AlMazroa, M. A., & Memish, Z. A. Lancet (London, England), 380(9859):2163–2196, December, 2012.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). METHODS: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. FINDINGS: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa. INTERPRETATION: Rates of YLDs per 100,000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world. FUNDING: Bill & Melinda Gates Foundation.
@article{vos_years_2012,
title = {Years lived with disability ({YLDs}) for 1160 sequelae of 289 diseases and injuries 1990-2010: {A} systematic analysis for the {Global} {Burden} of {Disease} {Study} 2010.},
volume = {380},
issn = {1474-547X},
shorttitle = {Years lived with disability ({YLDs}) for 1160 sequelae of 289 diseases and injuries 1990-2010},
doi = {10.1016/S0140-6736(12)61729-2},
abstract = {BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).
METHODS: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.
FINDINGS: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.
INTERPRETATION: Rates of YLDs per 100,000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.
FUNDING: Bill \& Melinda Gates Foundation.},
language = {ENG},
number = {9859},
journal = {Lancet (London, England)},
author = {Vos, Theo and Flaxman, Abraham D. and Naghavi, Mohsen and Lozano, Rafael and Michaud, Catherine and Ezzati, Majid and Shibuya, Kenji and Salomon, Joshua A. and Abdalla, Safa and Aboyans, Victor and Abraham, Jerry and Ackerman, Ilana and Aggarwal, Rakesh and Ahn, Stephanie Y. and Ali, Mohammed K. and Alvarado, Miriam and Anderson, H. Ross and Anderson, Laurie M. and Andrews, Kathryn G. and Atkinson, Charles and Baddour, Larry M. and Bahalim, Adil N. and Barker-Collo, Suzanne and Barrero, Lope H. and Bartels, David H. and Basáñez, Maria-Gloria and Baxter, Amanda and Bell, Michelle L. and Benjamin, Emelia J. and Bennett, Derrick and Bernabé, Eduardo and Bhalla, Kavi and Bhandari, Bishal and Bikbov, Boris and Bin Abdulhak, Aref and Birbeck, Gretchen and Black, James A. and Blencowe, Hannah and Blore, Jed D. and Blyth, Fiona and Bolliger, Ian and Bonaventure, Audrey and Boufous, Soufiane and Bourne, Rupert and Boussinesq, Michel and Braithwaite, Tasanee and Brayne, Carol and Bridgett, Lisa and Brooker, Simon and Brooks, Peter and Brugha, Traolach S. and Bryan-Hancock, Claire and Bucello, Chiara and Buchbinder, Rachelle and Buckle, Geoffrey and Budke, Christine M. and Burch, Michael and Burney, Peter and Burstein, Roy and Calabria, Bianca and Campbell, Benjamin and Canter, Charles E. and Carabin, Hélène and Carapetis, Jonathan and Carmona, Loreto and Cella, Claudia and Charlson, Fiona and Chen, Honglei and Cheng, Andrew Tai-Ann and Chou, David and Chugh, Sumeet S. and Coffeng, Luc E. and Colan, Steven D. and Colquhoun, Samantha and Colson, K. Ellicott and Condon, John and Connor, Myles D. and Cooper, Leslie T. and Corriere, Matthew and Cortinovis, Monica and de Vaccaro, Karen Courville and Couser, William and Cowie, Benjamin C. and Criqui, Michael H. and Cross, Marita and Dabhadkar, Kaustubh C. and Dahiya, Manu and Dahodwala, Nabila and Damsere-Derry, James and Danaei, Goodarz and Davis, Adrian and De Leo, Diego and Degenhardt, Louisa and Dellavalle, Robert and Delossantos, Allyne and Denenberg, Julie and Derrett, Sarah and Des Jarlais, Don C. and Dharmaratne, Samath D. and Dherani, Mukesh and Diaz-Torne, Cesar and Dolk, Helen and Dorsey, E. Ray and Driscoll, Tim and Duber, Herbert and Ebel, Beth and Edmond, Karen and Elbaz, Alexis and Ali, Suad Eltahir and Erskine, Holly and Erwin, Patricia J. and Espindola, Patricia and Ewoigbokhan, Stalin E. and Farzadfar, Farshad and Feigin, Valery and Felson, David T. and Ferrari, Alize and Ferri, Cleusa P. and Fèvre, Eric M. and Finucane, Mariel M. and Flaxman, Seth and Flood, Louise and Foreman, Kyle and Forouzanfar, Mohammad H. and Fowkes, Francis Gerry R. and Franklin, Richard and Fransen, Marlene and Freeman, Michael K. and Gabbe, Belinda J. and Gabriel, Sherine E. and Gakidou, Emmanuela and Ganatra, Hammad A. and Garcia, Bianca and Gaspari, Flavio and Gillum, Richard F. and Gmel, Gerhard and Gosselin, Richard and Grainger, Rebecca and Groeger, Justina and Guillemin, Francis and Gunnell, David and Gupta, Ramyani and Haagsma, Juanita and Hagan, Holly and Halasa, Yara A. and Hall, Wayne and Haring, Diana and Haro, Josep Maria and Harrison, James E. and Havmoeller, Rasmus and Hay, Roderick J. and Higashi, Hideki and Hill, Catherine and Hoen, Bruno and Hoffman, Howard and Hotez, Peter J. and Hoy, Damian and Huang, John J. and Ibeanusi, Sydney E. and Jacobsen, Kathryn H. and James, Spencer L. and Jarvis, Deborah and Jasrasaria, Rashmi and Jayaraman, Sudha and Johns, Nicole and Jonas, Jost B. and Karthikeyan, Ganesan and Kassebaum, Nicholas and Kawakami, Norito and Keren, Andre and Khoo, Jon-Paul and King, Charles H. and Knowlton, Lisa Marie and Kobusingye, Olive and Koranteng, Adofo and Krishnamurthi, Rita and Lalloo, Ratilal and Laslett, Laura L. and Lathlean, Tim and Leasher, Janet L. and Lee, Yong Yi and Leigh, James and Lim, Stephen S. and Limb, Elizabeth and Lin, John Kent and Lipnick, Michael and Lipshultz, Steven E. and Liu, Wei and Loane, Maria and Ohno, Summer Lockett and Lyons, Ronan and Ma, Jixiang and Mabweijano, Jacqueline and MacIntyre, Michael F. and Malekzadeh, Reza and Mallinger, Leslie and Manivannan, Sivabalan and Marcenes, Wagner and March, Lyn and Margolis, David J. and Marks, Guy B. and Marks, Robin and Matsumori, Akira and Matzopoulos, Richard and Mayosi, Bongani M. and McAnulty, John H. and McDermott, Mary M. and McGill, Neil and McGrath, John and Medina-Mora, Maria Elena and Meltzer, Michele and Mensah, George A. and Merriman, Tony R. and Meyer, Ana-Claire and Miglioli, Valeria and Miller, Matthew and Miller, Ted R. and Mitchell, Philip B. and Mocumbi, Ana Olga and Moffitt, Terrie E. and Mokdad, Ali A. and Monasta, Lorenzo and Montico, Marcella and Moradi-Lakeh, Maziar and Moran, Andrew and Morawska, Lidia and Mori, Rintaro and Murdoch, Michele E. and Mwaniki, Michael K. and Naidoo, Kovin and Nair, M. Nathan and Naldi, Luigi and Narayan, K. M. Venkat and Nelson, Paul K. and Nelson, Robert G. and Nevitt, Michael C. and Newton, Charles R. and Nolte, Sandra and Norman, Paul and Norman, Rosana and O'Donnell, Martin and O'Hanlon, Simon and Olives, Casey and Omer, Saad B. and Ortblad, Katrina and Osborne, Richard and Ozgediz, Doruk and Page, Andrew and Pahari, Bishnu and Pandian, Jeyaraj Durai and Rivero, Andrea Panozo and Patten, Scott B. and Pearce, Neil and Padilla, Rogelio Perez and Perez-Ruiz, Fernando and Perico, Norberto and Pesudovs, Konrad and Phillips, David and Phillips, Michael R. and Pierce, Kelsey and Pion, Sébastien and Polanczyk, Guilherme V. and Polinder, Suzanne and Pope, C. Arden and Popova, Svetlana and Porrini, Esteban and Pourmalek, Farshad and Prince, Martin and Pullan, Rachel L. and Ramaiah, Kapa D. and Ranganathan, Dharani and Razavi, Homie and Regan, Mathilda and Rehm, Jürgen T. and Rein, David B. and Remuzzi, Guiseppe and Richardson, Kathryn and Rivara, Frederick P. and Roberts, Thomas and Robinson, Carolyn and De Leòn, Felipe Rodriguez and Ronfani, Luca and Room, Robin and Rosenfeld, Lisa C. and Rushton, Lesley and Sacco, Ralph L. and Saha, Sukanta and Sampson, Uchechukwu and Sanchez-Riera, Lidia and Sanman, Ella and Schwebel, David C. and Scott, James Graham and Segui-Gomez, Maria and Shahraz, Saeid and Shepard, Donald S. and Shin, Hwashin and Shivakoti, Rupak and Singh, David and Singh, Gitanjali M. and Singh, Jasvinder A. and Singleton, Jessica and Sleet, David A. and Sliwa, Karen and Smith, Emma and Smith, Jennifer L. and Stapelberg, Nicolas J. C. and Steer, Andrew and Steiner, Timothy and Stolk, Wilma A. and Stovner, Lars Jacob and Sudfeld, Christopher and Syed, Sana and Tamburlini, Giorgio and Tavakkoli, Mohammad and Taylor, Hugh R. and Taylor, Jennifer A. and Taylor, William J. and Thomas, Bernadette and Thomson, W. Murray and Thurston, George D. and Tleyjeh, Imad M. and Tonelli, Marcello and Towbin, Jeffrey A. and Truelsen, Thomas and Tsilimbaris, Miltiadis K. and Ubeda, Clotilde and Undurraga, Eduardo A. and van der Werf, Marieke J. and van Os, Jim and Vavilala, Monica S. and Venketasubramanian, N. and Wang, Mengru and Wang, Wenzhi and Watt, Kerrianne and Weatherall, David J. and Weinstock, Martin A. and Weintraub, Robert and Weisskopf, Marc G. and Weissman, Myrna M. and White, Richard A. and Whiteford, Harvey and Wiersma, Steven T. and Wilkinson, James D. and Williams, Hywel C. and Williams, Sean R. M. and Witt, Emma and Wolfe, Frederick and Woolf, Anthony D. and Wulf, Sarah and Yeh, Pon-Hsiu and Zaidi, Anita K. M. and Zheng, Zhi-Jie and Zonies, David and Lopez, Alan D. and Murray, Christopher J. L. and AlMazroa, Mohammad A. and Memish, Ziad A.},
month = dec,
year = {2012},
pmid = {23245607},
keywords = {Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Global Health, Health Status, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Prevalence, Quality-Adjusted Life Years, Sex Factors, Wounds and Injuries, Young Adult},
pages = {2163--2196}
}Serum PBDEs in a North Carolina toddler cohort: associations with handwipes, house dust, and socioeconomic variables. Stapleton, H. M, Eagle, S., Sjödin, A., & Webster, T. F Environmental health perspectives, 120(7):1049--54, July, 2012.
Paper doi abstract bibtex
Paper doi abstract bibtex Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals.
@article{stapleton_serum_2012-1,
title = {Serum {PBDEs} in a {North} {Carolina} toddler cohort: associations with handwipes, house dust, and socioeconomic variables.},
volume = {120},
issn = {1552-9924},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3404669&tool=pmcentrez&rendertype=abstract},
doi = {10.1289/ehp.1104802},
abstract = {Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals.},
number = {7},
journal = {Environmental health perspectives},
author = {Stapleton, Heather M and Eagle, Sarah and Sjödin, Andreas and Webster, Thomas F},
month = jul,
year = {2012},
pmid = {22763040},
keywords = {Age Factors, Child, Dust, Dust: analysis, Female, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: blood, Humans, Infant, Male, Multivariate Analysis, North Carolina, Polybrominated Biphenyls, Polybrominated Biphenyls: blood, Preschool, Sex Factors, unsure},
pages = {1049--54}
}Health service use in families where children enter public care: a nested case control study using the General Practice Research Database. Simkiss, D. E., Spencer, N. J., Stallard, N., & Thorogood, M. BMC health services research, 12:65, 2012.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: At least 3% of children spend some of their childhood in public care and, as a group, have poor outcomes across a range of education, employment, health and social care outcomes. Research, using social care or government datasets, has identified a number of risk factors associated with children entering public care but the utility of risk factors in clinical practice is not established. This paper uses routine primary health care data to see if risk factors for children entering public care can be identified in clinical practice. METHODS: A nested case control methodology using routine primary care data from the United Kingdom. Health service use data were extracted for the 12 months before the case child entered public care and compared with 12 months of data for four control mother child pairs per case pair, matched on the age and sex of the child and the general practice. Exposures of interest were developed from a systematic review of the literature on risk factors associated with children entering public care. RESULTS: Conditional logistic regression was used to investigate the combined effect of more than one exposure of interest. Maternal mental illness (OR 2.51, 95% CI 1.55-4.05), maternal age at birth of the child, socio-economic status (5(th) quintile vs. 1(st) quintile OR 7.14, 95% CI 2.92-17.4), maternal drug use (OR 28.8, 95% CI 2.29-363), non attendance at appointments (OR 2.42, 95% CI 1.42-4.14), child mental illness (OR 2.65, 95% CI 1.42-4.96) and child admission to hospital (OR 3.31, 95% CI 1.21-9.02) were all significantly associated with children entering public care. Maternal use of primary care contraception services was negatively associated with children entering public care (OR 0.52, 95% CI 0.31-0.87). CONCLUSIONS: Differences in health service use can be identified from routine primary care data in mother child pairs where children enter public care after controlling for maternal age and socio-economic status. The interaction between different risk factors needs testing in a cumulative risk model using longitudinal datasets.
@article{simkiss_health_2012,
title = {Health service use in families where children enter public care: a nested case control study using the {General} {Practice} {Research} {Database}},
volume = {12},
issn = {1472-6963},
shorttitle = {Health service use in families where children enter public care},
doi = {10.1186/1472-6963-12-65},
abstract = {BACKGROUND: At least 3\% of children spend some of their childhood in public care and, as a group, have poor outcomes across a range of education, employment, health and social care outcomes. Research, using social care or government datasets, has identified a number of risk factors associated with children entering public care but the utility of risk factors in clinical practice is not established. This paper uses routine primary health care data to see if risk factors for children entering public care can be identified in clinical practice.
METHODS: A nested case control methodology using routine primary care data from the United Kingdom. Health service use data were extracted for the 12 months before the case child entered public care and compared with 12 months of data for four control mother child pairs per case pair, matched on the age and sex of the child and the general practice. Exposures of interest were developed from a systematic review of the literature on risk factors associated with children entering public care.
RESULTS: Conditional logistic regression was used to investigate the combined effect of more than one exposure of interest. Maternal mental illness (OR 2.51, 95\% CI 1.55-4.05), maternal age at birth of the child, socio-economic status (5(th) quintile vs. 1(st) quintile OR 7.14, 95\% CI 2.92-17.4), maternal drug use (OR 28.8, 95\% CI 2.29-363), non attendance at appointments (OR 2.42, 95\% CI 1.42-4.14), child mental illness (OR 2.65, 95\% CI 1.42-4.96) and child admission to hospital (OR 3.31, 95\% CI 1.21-9.02) were all significantly associated with children entering public care. Maternal use of primary care contraception services was negatively associated with children entering public care (OR 0.52, 95\% CI 0.31-0.87).
CONCLUSIONS: Differences in health service use can be identified from routine primary care data in mother child pairs where children enter public care after controlling for maternal age and socio-economic status. The interaction between different risk factors needs testing in a cumulative risk model using longitudinal datasets.},
language = {eng},
journal = {BMC health services research},
author = {Simkiss, Douglas E. and Spencer, Nicholas J. and Stallard, Nigel and Thorogood, Margaret},
year = {2012},
pmid = {22424404},
pmcid = {PMC3361673},
keywords = {Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Databases, Factual, Family Health, Female, General Practice, Great Britain, Health Services Research, Hospitalization, Humans, Infant, Logistic Models, Male, Maternal Age, Maternal-Child Health Centers, Mental Disorders, Middle Aged, Mothers, Primary Health Care, Public Sector, Questionnaires, Risk Factors, Social Class, Young Adult},
pages = {65}
}Spinal cord ependymomas in children and adolescents. Benesch, M., Frappaz, D., & Massimino, M. Child's nervous system, 28(12):2017-28, 12, 2012.
Paper abstract bibtex
Paper abstract bibtex BACKGROUND: Spinal cord ependymomas are very rare among children and adolescents. Due to their rarity, our current knowledge of these tumors is based on case reports and few retrospective case series. METHODS: The present review summarizes the currently available literature on childhood spinal cord ependymomas. RESULTS: Although overall survival rates are favorable, relapse incidence is high, particularly in myxopapillary ependymomas. Since long-term follow-up data are provided in a limited number of studies only, the true relapse incidence is unknown. Maximal safe radical surgery is the backbone of treatment for children with spinal cord ependymomas, but the impact of adjuvant treatment on progression and survival is still unclear. Presently, the decision to initiate non-surgical treatment depends primarily on the WHO grade of the tumor and the extent of resection. In terms of the known side effects, early radiotherapy should be avoided in children with WHO grade II spinal cord ependymomas irrespective of the extent of resection but is indicated in anaplastic spinal cord ependymomas both after complete and incomplete resection. The high relapse incidence in myxopapillary ependymomas argue for the use of early radiotherapy, but its definitive impact on progression has to be proven in larger series. Close surveillance is important due to the high recurrence rate in all patients with spinal cord ependymomas. CONCLUSION: Prospective collection of both clinical and molecular data from a greater number of patients with spinal cord ependymomas within an international collaboration is the prerequisite to establish standardized management guidelines for these rare CNS tumors.
@article{
title = {Spinal cord ependymomas in children and adolescents.},
type = {article},
year = {2012},
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keywords = {Adjuvant,Adolescent,Brain Neoplasms,Brain Neoplasms: genetics,Brain Neoplasms: pathology,Brain Neoplasms: therapy,Chemoradiotherapy,Child,Ependymoma,Ependymoma: complications,Ependymoma: genetics,Ependymoma: pathology,Ependymoma: therapy,Humans,Infant,Neoplasm Staging,Neurofibromatosis 2,Neurofibromatosis 2: complications,Neurofibromatosis 2: therapy,Neurosurgical Procedures,Newborn,Preschool,Prognosis,Spinal Cord Neoplasms,Spinal Cord Neoplasms: complications,Spinal Cord Neoplasms: genetics,Spinal Cord Neoplasms: pathology,Spinal Cord Neoplasms: therapy},
pages = {2017-28},
volume = {28},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/22961356},
month = {12},
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abstract = {BACKGROUND: Spinal cord ependymomas are very rare among children and adolescents. Due to their rarity, our current knowledge of these tumors is based on case reports and few retrospective case series. METHODS: The present review summarizes the currently available literature on childhood spinal cord ependymomas. RESULTS: Although overall survival rates are favorable, relapse incidence is high, particularly in myxopapillary ependymomas. Since long-term follow-up data are provided in a limited number of studies only, the true relapse incidence is unknown. Maximal safe radical surgery is the backbone of treatment for children with spinal cord ependymomas, but the impact of adjuvant treatment on progression and survival is still unclear. Presently, the decision to initiate non-surgical treatment depends primarily on the WHO grade of the tumor and the extent of resection. In terms of the known side effects, early radiotherapy should be avoided in children with WHO grade II spinal cord ependymomas irrespective of the extent of resection but is indicated in anaplastic spinal cord ependymomas both after complete and incomplete resection. The high relapse incidence in myxopapillary ependymomas argue for the use of early radiotherapy, but its definitive impact on progression has to be proven in larger series. Close surveillance is important due to the high recurrence rate in all patients with spinal cord ependymomas. CONCLUSION: Prospective collection of both clinical and molecular data from a greater number of patients with spinal cord ependymomas within an international collaboration is the prerequisite to establish standardized management guidelines for these rare CNS tumors.},
bibtype = {article},
author = {Benesch, Martin and Frappaz, Didier and Massimino, Maura},
journal = {Child's nervous system},
number = {12}
}Semi-recumbent body position fails to prevent healthcare-associated pneumonia in Vietnamese patients with severe tetanus. Loan H.T., Parry J., Nga N.T., Yen L.M., Binh N.T., Thuy T.T., Duong N.M., Campbell J.I., Thwaites L., Farrar J.J., & Parry C.M. 2012.
abstract bibtex
abstract bibtex
Healthcare-associated pneumonia (HCAP) is a common complication in patients with severe tetanus. Nursing tetanus patients in a semi-recumbent body position could reduce the incidence of HCAP. In a randomised controlled trial we compared the occurrence of HCAP in patients with severe tetanus nursed in a semi-recumbent (30degree) or supine position. A total of 229 adults and children (aged \textgreater1 year) with severe tetanus admitted to hospital in Vietnam, were randomly assigned to a supine (n=112) or semi-recumbent (n=117) position. For patients maintaining their assigned positions and in hospital for\textgreater48h there was no significant difference between the two groups in the frequency of clinically suspected pneumonia [22/106 (20.8%) vs 26/104 (25.0%); p=0.464], pneumonia rate/1000 intensive care unit days (13.9 vs 14.6; p=0.48) and pneumonia rate/1000 ventilated days (39.2 vs 38.1; p=0.72). Mortality in the supine patients was 11/112 (9.8%) compared with 17/117 (14.5%) in the semi-recumbent patients (p=0.277). The overall complication rate [57/112 (50.9%) vs 76/117 (65.0%); p=0.03] and need for tracheostomy [51/112 (45.5%) vs 69/117 (58.9%); p=0.04) was greater in semi-recumbent patients. Semi-recumbent body positioning did not prevent the occurrence of HCAP in severe tetanus patients. Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
@misc{loan_h.t._semi-recumbent_2012,
title = {Semi-recumbent body position fails to prevent healthcare-associated pneumonia in {Vietnamese} patients with severe tetanus},
abstract = {Healthcare-associated pneumonia (HCAP) is a common complication in patients with severe tetanus. Nursing tetanus patients in a semi-recumbent body position could reduce the incidence of HCAP. In a randomised controlled trial we compared the occurrence of HCAP in patients with severe tetanus nursed in a semi-recumbent (30degree) or supine position. A total of 229 adults and children (aged {\textgreater}1 year) with severe tetanus admitted to hospital in Vietnam, were randomly assigned to a supine (n=112) or semi-recumbent (n=117) position. For patients maintaining their assigned positions and in hospital for{\textgreater}48h there was no significant difference between the two groups in the frequency of clinically suspected pneumonia [22/106 (20.8\%) vs 26/104 (25.0\%); p=0.464], pneumonia rate/1000 intensive care unit days (13.9 vs 14.6; p=0.48) and pneumonia rate/1000 ventilated days (39.2 vs 38.1; p=0.72). Mortality in the supine patients was 11/112 (9.8\%) compared with 17/117 (14.5\%) in the semi-recumbent patients (p=0.277). The overall complication rate [57/112 (50.9\%) vs 76/117 (65.0\%); p=0.03] and need for tracheostomy [51/112 (45.5\%) vs 69/117 (58.9\%); p=0.04) was greater in semi-recumbent patients. Semi-recumbent body positioning did not prevent the occurrence of HCAP in severe tetanus patients. Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.},
journal = {Transactions of the Royal Society of Tropical Medicine and Hygiene},
author = {{Loan H.T.} and {Parry J.} and {Nga N.T.} and {Yen L.M.} and {Binh N.T.} and {Thuy T.T.} and {Duong N.M.} and {Campbell J.I.} and {Thwaites L.} and {Farrar J.J.} and {Parry C.M.}},
year = {2012},
keywords = {*patient positioning, Child, Viet Nam, adolescent, adult, aged, artificial ventilation, comparative study, complication, controlled study, cross infection/ep [Epidemiology], cross infection/pc [Prevention], female, human, incidence, infant, intensive care unit, male, microbiology, middle aged, pneumonia/ep [Epidemiology], pneumonia/et [Etiology], pneumonia/pc [Prevention], preschool child, randomized controlled trial, tetanus, tracheostomy, treatment failure, young adult}
}2011 (6)
The London low emission zone baseline study. Kelly, F., Armstrong, B., Atkinson, R., Anderson, H. R., Barratt, B., Beevers, S., Cook, D., Green, D., Derwent, D., Mudway, I., Wilkinson, P., & HEI Health Review Committee Research Report (Health Effects Institute), November, 2011.
abstract bibtex
abstract bibtex
On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter \textless or = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these suggested that the clearest signals of change were most likely to be measured near roadsides. The seven key areas were also likely to be of importance in carrying out a study to assess the health outcomes of an air quality intervention like the LEZ. Of the seven key areas, two already had monitoring sites with a full complement of equipment, four had monitoring sites that required upgrades of existing equipment, and one required a completely new installation. With the upgrades and new installations in place, fully ratified (verified) pollutant data (for PM10, PM with an aerodynamic diameter \textless or = 2.5 microm [PM2.5], nitrogen oxides [NOx], and ozone [O3] at all sites as well as for particle number, black smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites) were then collected for analysis. In addition, the seven key monitoring sites were supported by other sites in the London Air Quality Network (LAQN). From these, a robust set of baseline air quality data was produced. Data from automatic and manual traffic counters as well as automatic license-plate recognition cameras were used to compile detailed vehicle profiles. This enabled us to establish more precise associations between ambient pollutant concentrations and vehicle emissions. An additional goal of the study was to collect baseline PM data in order to test the hypothesis that changes in traffic densities and vehicle mixes caused by the LEZ would affect the oxidative potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM data set was the first to describe, in detail, the oxidative potential and metal content of the PM10 and PM2.5 of a major city's airshed. PM in London has considerable oxidative potential; clear differences in this measure were found from site to site, with evidence that the oxidative potential of both PM10 and PM2.5 at roadside monitoring sites was higher than at urban background locations. In the PM10 samples this increased oxidative activity appeared to be associated with increased concentrations of copper (Cu), barium (Ba), and bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. In the PM2.5 samples, no simple association could be seen, suggesting that other unmeasured components were driving the increased oxidative potential in this fraction of the roadside samples. These data suggest that two components were contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10 microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived for this baseline study confirmed key observations from a more limited spatial mapping exercise published in our earlier HEI report on the introduction of the London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In addition, the data set in the current report provided robust baseline information on the oxidative potential and metal content of PM found in the London airshed in the period before implementation of the LEZ; the finding that a proportion of the oxidative potential appears in the PM coarse mode and is apparently related to brake wear raises important issues regarding the nature of traffic management schemes. The final goal of this baseline study was to establish the feasibility, in ethical and operational terms, of using the U.K.'s electronic primary-care records to evaluate the effects of the LEZ on human health outcomes. Data on consultations and prescriptions were compiled from a pilot group of general practices (13 distributed across London, with 100,000 patients; 29 situated in the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals were obtained to link individual primary-care records to modeled NOx concentrations by means of post-codes. (To preserve anonymity, the postcodes were removed before delivery to the research team.) A wide range of NOx exposures was found across London as well as within and between the practices examined. Although we observed little association between NOx exposure and smoking status, a positive relationship was found between exposure and increased socioeconomic deprivation. The health outcomes we chose to study were asthma, chronic obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory tract infections, ischemic heart disease, heart failure, and atrial fibrillation. These outcomes were measured as prevalence or incidence. Their distributions by age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord with those reported in the epidemiology literature. No cross-sectional positive associations were found between exposure to NOx and any of the studied health outcomes; some associations were significantly negative. After the pilot study, a suitable primary-care database of London patients was identified, the General Practice Research Database responsible for giving us access to these data agreed to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring privacy of the records was agreed upon. The database included about 350,000 patients who had remained at the same address over the four-year period of the study. Power calculations for a controlled longitudinal analysis were then performed, indicating that for outcomes such as consultations for respiratory illnesses or prescriptions for asthma there was sufficient power to identify a 5% to 10% reduction in consultations for patients most exposed to the intervention compared with patients presumed to not be exposed to it. In conclusion, the work undertaken in this study provides a good foundation for future LEZ evaluations. Our extensive monitoring network, measuring a comprehensive set of pollutants (and a range of particle metrics), will continue to provide a valuable tool both for assessing the impact of LEZ regulations on air quality in London and for furthering understanding of the link between PM's composition and toxicity. Finally, we believe that in combination with our modeling of the predicted population-based changes in pollution exposure in London, the use of primary-care databases forms a sound basis and has sufficient statistical power for the evaluation of the potential impact of the LEZ on human health.
@article{kelly_london_2011,
title = {The {London} low emission zone baseline study},
issn = {1041-5505},
abstract = {On February 4, 2008, the world's largest low emission zone (LEZ) was established. At 2644 km2, the zone encompasses most of Greater London. It restricts the entry of the oldest and most polluting diesel vehicles, including heavy-goods vehicles (haulage trucks), buses and coaches, larger vans, and minibuses. It does not apply to cars or motorcycles. The LEZ scheme will introduce increasingly stringent Euro emissions standards over time. The creation of this zone presented a unique opportunity to estimate the effects of a stepwise reduction in vehicle emissions on air quality and health. Before undertaking such an investigation, robust baseline data were gathered on air quality and the oxidative activity and metal content of particulate matter (PM) from air pollution monitors located in Greater London. In addition, methods were developed for using databases of electronic primary-care records in order to evaluate the zone's health effects. Our study began in 2007, using information about the planned restrictions in an agreed-upon LEZ scenario and year-on-year changes in the vehicle fleet in models to predict air pollution concentrations in London for the years 2005, 2008, and 2010. Based on this detailed emissions and air pollution modeling, the areas in London were then identified that were expected to show the greatest changes in air pollution concentrations and population exposures after the implementation of the LEZ. Using these predictions, the best placement of a pollution monitoring network was determined and the feasibility of evaluating the health effects using electronic primary-care records was assessed. To measure baseline pollutant concentrations before the implementation of the LEZ, a comprehensive monitoring network was established close to major roadways and intersections. Output-difference plots from statistical modeling for 2010 indicated seven key areas likely to experience the greatest change in concentrations of nitrogen dioxide (NO2) (at least 3 microg/m3) and of PM with an aerodynamic diameter {\textless} or = 10 microm (PM10) (at least 0.75 microg/m3) as a result of the LEZ; these suggested that the clearest signals of change were most likely to be measured near roadsides. The seven key areas were also likely to be of importance in carrying out a study to assess the health outcomes of an air quality intervention like the LEZ. Of the seven key areas, two already had monitoring sites with a full complement of equipment, four had monitoring sites that required upgrades of existing equipment, and one required a completely new installation. With the upgrades and new installations in place, fully ratified (verified) pollutant data (for PM10, PM with an aerodynamic diameter {\textless} or = 2.5 microm [PM2.5], nitrogen oxides [NOx], and ozone [O3] at all sites as well as for particle number, black smoke [BS], carbon monoxide [CO], and sulfur dioxide [SO2] at selected sites) were then collected for analysis. In addition, the seven key monitoring sites were supported by other sites in the London Air Quality Network (LAQN). From these, a robust set of baseline air quality data was produced. Data from automatic and manual traffic counters as well as automatic license-plate recognition cameras were used to compile detailed vehicle profiles. This enabled us to establish more precise associations between ambient pollutant concentrations and vehicle emissions. An additional goal of the study was to collect baseline PM data in order to test the hypothesis that changes in traffic densities and vehicle mixes caused by the LEZ would affect the oxidative potential and metal content of ambient PM10 and PM2.5. The resulting baseline PM data set was the first to describe, in detail, the oxidative potential and metal content of the PM10 and PM2.5 of a major city's airshed. PM in London has considerable oxidative potential; clear differences in this measure were found from site to site, with evidence that the oxidative potential of both PM10 and PM2.5 at roadside monitoring sites was higher than at urban background locations. In the PM10 samples this increased oxidative activity appeared to be associated with increased concentrations of copper (Cu), barium (Ba), and bathophenanthroline disulfonate-mobilized iron (BPS Fe) in the roadside samples. In the PM2.5 samples, no simple association could be seen, suggesting that other unmeasured components were driving the increased oxidative potential in this fraction of the roadside samples. These data suggest that two components were contributing to the oxidative potential of roadside PM, namely Cu and BPS Fe in the coarse fraction of PM (PM with an aerodynamic diameter of 2.5 microm to 10 microm; PM(2.5-10)) and an unidentified redox catalyst in PM2.5. The data derived for this baseline study confirmed key observations from a more limited spatial mapping exercise published in our earlier HEI report on the introduction of the London's Congestion Charging Scheme (CCS) in 2003 (Kelly et al. 2011a,b). In addition, the data set in the current report provided robust baseline information on the oxidative potential and metal content of PM found in the London airshed in the period before implementation of the LEZ; the finding that a proportion of the oxidative potential appears in the PM coarse mode and is apparently related to brake wear raises important issues regarding the nature of traffic management schemes. The final goal of this baseline study was to establish the feasibility, in ethical and operational terms, of using the U.K.'s electronic primary-care records to evaluate the effects of the LEZ on human health outcomes. Data on consultations and prescriptions were compiled from a pilot group of general practices (13 distributed across London, with 100,000 patients; 29 situated in the inner London Borough of Lambeth, with 200,000 patients). Ethics approvals were obtained to link individual primary-care records to modeled NOx concentrations by means of post-codes. (To preserve anonymity, the postcodes were removed before delivery to the research team.) A wide range of NOx exposures was found across London as well as within and between the practices examined. Although we observed little association between NOx exposure and smoking status, a positive relationship was found between exposure and increased socioeconomic deprivation. The health outcomes we chose to study were asthma, chronic obstructive pulmonary disease, wheeze, hay fever, upper and lower respiratory tract infections, ischemic heart disease, heart failure, and atrial fibrillation. These outcomes were measured as prevalence or incidence. Their distributions by age, sex, socioeconomic deprivation, ethnicity, and smoking were found to accord with those reported in the epidemiology literature. No cross-sectional positive associations were found between exposure to NOx and any of the studied health outcomes; some associations were significantly negative. After the pilot study, a suitable primary-care database of London patients was identified, the General Practice Research Database responsible for giving us access to these data agreed to collaborate in the evaluation of the LEZ, and an acceptable method of ensuring privacy of the records was agreed upon. The database included about 350,000 patients who had remained at the same address over the four-year period of the study. Power calculations for a controlled longitudinal analysis were then performed, indicating that for outcomes such as consultations for respiratory illnesses or prescriptions for asthma there was sufficient power to identify a 5\% to 10\% reduction in consultations for patients most exposed to the intervention compared with patients presumed to not be exposed to it. In conclusion, the work undertaken in this study provides a good foundation for future LEZ evaluations. Our extensive monitoring network, measuring a comprehensive set of pollutants (and a range of particle metrics), will continue to provide a valuable tool both for assessing the impact of LEZ regulations on air quality in London and for furthering understanding of the link between PM's composition and toxicity. Finally, we believe that in combination with our modeling of the predicted population-based changes in pollution exposure in London, the use of primary-care databases forms a sound basis and has sufficient statistical power for the evaluation of the potential impact of the LEZ on human health.},
language = {eng},
number = {163},
journal = {Research Report (Health Effects Institute)},
author = {Kelly, Frank and Armstrong, Ben and Atkinson, Richard and Anderson, H. Ross and Barratt, Ben and Beevers, Sean and Cook, Derek and Green, Dave and Derwent, Dick and Mudway, Ian and Wilkinson, Paul and {HEI Health Review Committee}},
month = nov,
year = {2011},
pmid = {22315924},
keywords = {Adolescent, Adult, Aged, Air Pollutants, Air Pollution, Child, Child, Preschool, Cross-Sectional Studies, Environmental Exposure, Environmental Monitoring, Female, Health Status, Humans, Infant, London, Longitudinal Studies, Male, Metals, Middle Aged, Nitrogen Oxides, Particulate Matter, Pilot Projects, Primary Health Care, Small-Area Analysis, Smoking, Socioeconomic Factors, Vehicle Emissions, Young Adult},
pages = {3--79}
}Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in England, 2001 to 2005. Kotz, D., Simpson, C. R., & Sheikh, A. The Journal of Allergy and Clinical Immunology, 127(3):623--630.e1, March, 2011.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Previous descriptions of the epidemiology of peanut allergy have mainly been derived from small cross-sectional studies. OBJECTIVE: To interrogate a large national research database to provide estimates for the incidence, prevalence, and trends of general practitioner (GP)-recorded diagnosis of peanut allergy in the English population. METHODS: Version 10 of the QRESEARCH database was used with data from 2,958,366 patients who were registered with 422 United Kingdom general practices in the years 2001 to 2005. The primary outcome was a recording of clinician-diagnosed peanut allergy. RESULTS: The age-sex standardized incidence rate of peanut allergy in 2005 was 0.08 per 1000 person-years (95% CI, 0.07-0.08), and the prevalence rate was 0.51 per 1000 patients (95% CI, 0.49-0.54). This translated into an estimated 4000 incident cases (95% CI, 3500-4600) and 25,700 prevalent cases (95% CI, 24,400-27,100) of GP-recorded diagnosis of peanut allergy in England in 2005. During the study period, the incidence rate of peanut allergy remained fairly stable, whereas the prevalence rate doubled. In those under 18 years of age, the crude lifetime prevalence rate was higher in males than females. A significant inverse relationship between prevalence and socioeconomic status was found. CONCLUSION: These data on GP-recorded diagnosis of peanut allergy from a large general practice database suggest a much lower prevalence in peanut allergy than has hitherto been found. This difference may in part be explained by underrecording of peanut allergy in general practice. Further research is needed to assess the true frequency of peanut allergy in the population and whether there has been a true increase in recent years.
@article{kotz_incidence_2011,
title = {Incidence, prevalence, and trends of general practitioner-recorded diagnosis of peanut allergy in {England}, 2001 to 2005},
volume = {127},
issn = {1097-6825},
doi = {10.1016/j.jaci.2010.11.021},
abstract = {BACKGROUND: Previous descriptions of the epidemiology of peanut allergy have mainly been derived from small cross-sectional studies.
OBJECTIVE: To interrogate a large national research database to provide estimates for the incidence, prevalence, and trends of general practitioner (GP)-recorded diagnosis of peanut allergy in the English population.
METHODS: Version 10 of the QRESEARCH database was used with data from 2,958,366 patients who were registered with 422 United Kingdom general practices in the years 2001 to 2005. The primary outcome was a recording of clinician-diagnosed peanut allergy.
RESULTS: The age-sex standardized incidence rate of peanut allergy in 2005 was 0.08 per 1000 person-years (95\% CI, 0.07-0.08), and the prevalence rate was 0.51 per 1000 patients (95\% CI, 0.49-0.54). This translated into an estimated 4000 incident cases (95\% CI, 3500-4600) and 25,700 prevalent cases (95\% CI, 24,400-27,100) of GP-recorded diagnosis of peanut allergy in England in 2005. During the study period, the incidence rate of peanut allergy remained fairly stable, whereas the prevalence rate doubled. In those under 18 years of age, the crude lifetime prevalence rate was higher in males than females. A significant inverse relationship between prevalence and socioeconomic status was found.
CONCLUSION: These data on GP-recorded diagnosis of peanut allergy from a large general practice database suggest a much lower prevalence in peanut allergy than has hitherto been found. This difference may in part be explained by underrecording of peanut allergy in general practice. Further research is needed to assess the true frequency of peanut allergy in the population and whether there has been a true increase in recent years.},
language = {eng},
number = {3},
journal = {The Journal of Allergy and Clinical Immunology},
author = {Kotz, Daniel and Simpson, Colin R. and Sheikh, Aziz},
month = mar,
year = {2011},
pmid = {21236479},
keywords = {Adolescent, Adult, Child, Child, Preschool, England, Female, General Practitioners, Great Britain, Humans, Infant, Male, Medical Records, Peanut Hypersensitivity, Prevalence, incidence},
pages = {623--630.e1}
}Childhood hemangiopericytoma: review of St Jude Children's Research Hospital. Fernandez-Pineda, I., Parida, L., Jenkins, J. J., Davidoff, A. M., Rao, B. N., & Rodriguez-Galindo, C. Journal of Pediatric Hematology/Oncology, 33(5):356--359, July, 2011.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Hemangiopericytoma (HPC) is a heterogeneous, highly vascularized malignant soft-tissue neoplasm with 2 different clinical presentations: adult-type and infantile-type HPC. Intracranial HPC represents a special subtype with a high proclivity toward recurrence and metastasis. METHODS: The authors have reviewed the clinical features, response to treatment, and outcomes of 17 patients with HPC treated at St Jude Children's Research Hospital from 1962 to 2009. RESULTS: At diagnosis, 11 patients were older than 1 year (subgroup A) and 6 patients were younger than 1 year (subgroup B). Subgroup A: median age at diagnosis 13.5 years, (range, 4 to 20 y). Primary sites were intracranial (n=5), thigh (n=3), calf (n=1), foot (n=1), and scalp (n=1). One patient who presented with a thigh HPC had metastatic disease at diagnosis, and 3 patients with head location had unresectable tumors. Two patients with thigh location experienced objective responses to chemotherapy. Six patients died of disease progression, 4 of them had an intracranial location. The remaining 5 children are alive at follow-up of 12 to 32 years. Subgroup B: median age at diagnosis 0.5 months (range, 0 to 3 mo). Primary sites were thigh (n=2), calf (n=1), perianal (n=1), forearm (n=1), and lung (n=1). Three patients with limb location had unresectable disease at diagnosis, 2 of them experienced excellent responses to neoadjuvant chemotherapy and 1 did not show any response to chemotherapy and a staged resection was performed. All 6 infants are alive without evidence of disease at follow-up of 2 to 27 years. CONCLUSIONS: Infantile HPC is characterized by a better clinical behavior than the adult type, which requires an aggressive multimodality therapy. Chemoresponsiveness and spontaneous regression have been reported in children younger than 1 year, suggesting that a more conservative surgical approach should be used. Intracranial HPC is considered as an aggressive tumor because of its propensity for recurrence and metastasis.
@article{fernandez-pineda_childhood_2011,
title = {Childhood hemangiopericytoma: review of {St} {Jude} {Children}'s {Research} {Hospital}},
volume = {33},
issn = {1536-3678},
shorttitle = {Childhood hemangiopericytoma},
doi = {10.1097/MPH.0b013e318214e667},
abstract = {BACKGROUND: Hemangiopericytoma (HPC) is a heterogeneous, highly vascularized malignant soft-tissue neoplasm with 2 different clinical presentations: adult-type and infantile-type HPC. Intracranial HPC represents a special subtype with a high proclivity toward recurrence and metastasis.
METHODS: The authors have reviewed the clinical features, response to treatment, and outcomes of 17 patients with HPC treated at St Jude Children's Research Hospital from 1962 to 2009.
RESULTS: At diagnosis, 11 patients were older than 1 year (subgroup A) and 6 patients were younger than 1 year (subgroup B). Subgroup A: median age at diagnosis 13.5 years, (range, 4 to 20 y). Primary sites were intracranial (n=5), thigh (n=3), calf (n=1), foot (n=1), and scalp (n=1). One patient who presented with a thigh HPC had metastatic disease at diagnosis, and 3 patients with head location had unresectable tumors. Two patients with thigh location experienced objective responses to chemotherapy. Six patients died of disease progression, 4 of them had an intracranial location. The remaining 5 children are alive at follow-up of 12 to 32 years. Subgroup B: median age at diagnosis 0.5 months (range, 0 to 3 mo). Primary sites were thigh (n=2), calf (n=1), perianal (n=1), forearm (n=1), and lung (n=1). Three patients with limb location had unresectable disease at diagnosis, 2 of them experienced excellent responses to neoadjuvant chemotherapy and 1 did not show any response to chemotherapy and a staged resection was performed. All 6 infants are alive without evidence of disease at follow-up of 2 to 27 years.
CONCLUSIONS: Infantile HPC is characterized by a better clinical behavior than the adult type, which requires an aggressive multimodality therapy. Chemoresponsiveness and spontaneous regression have been reported in children younger than 1 year, suggesting that a more conservative surgical approach should be used. Intracranial HPC is considered as an aggressive tumor because of its propensity for recurrence and metastasis.},
language = {eng},
number = {5},
journal = {Journal of Pediatric Hematology/Oncology},
author = {Fernandez-Pineda, Israel and Parida, Lalit and Jenkins, Jesse J. and Davidoff, Andrew M. and Rao, Bhaskar N. and Rodriguez-Galindo, Carlos},
month = jul,
year = {2011},
pmid = {21602721},
keywords = {Adolescent, Adult, Brain Neoplasms, Child, Child, Preschool, Female, Follow-Up Studies, Hemangiopericytoma, Hospitals, Pediatric, Humans, Infant, Male, Neoplasm Recurrence, Local, Neoplasm Staging, Soft Tissue Neoplasms, Young Adult},
pages = {356--359}
}Provider and pharmacist responses to warfarin drug-drug interaction alerts: a study of healthcare downstream of CPOE alerts. Miller, A. M, Boro, M. S, Korman, N. E, & Davoren, J B. Journal of the American Medical Informatics Association: JAMIA, 18 Suppl 1:i45–50, December, 2011.
doi abstract bibtex
doi abstract bibtex
OBJECTIVE: To categorize the appropriateness of provider and pharmacist responses to warfarin critical drug-drug interaction (cDDI) alerts, assess responses and actions to the cDDI, and determine the occurrence of warfarin adverse drug events (ADE) after alerts. DESIGN: An 18-month, retrospective study of acute care admissions at a single Veterans Affairs medical center using computerized provider order entry (CPOE). MEASUREMENTS: Patients included had at least one warfarin cDDI alert. Chart reviews included baseline laboratory values and demographics, provider actions, patient outcomes, and associated factors, including other interacting medications and number of simultaneously processed alerts. RESULTS: 137 admissions were included (133 unique patients). Amiodarone, vitamin E in a multivitamin, sulfamethoxazole, and levothyroxine accounted for 75% of warfarin cDDI. Provider responses were clinically appropriate in 19.7% of admissions and pharmacist responses were appropriate in 9.5% of admissions. There were 50 ADE (36.6% of admissions) with warfarin; 80% were rated as having no or mild clinical effect. An increased number of non-critical alerts at the time of the reference cDDI alert was the only variable associated with an inappropriate provider response (p=0.01). LIMITATIONS: This study was limited by being a retrospective review and the possibility of confounding variables, such as other interacting medications. CONCLUSION: The large number of CPOE alerts may lead to inappropriate responses by providers and pharmacists. The high rate of ADE suggests a need for improved medication management systems for patients on warfarin. This study highlights the possibility of alert fatigue contributing to the high prevalence of inappropriate alert over-ride text responses.
@article{miller_provider_2011,
title = {Provider and pharmacist responses to warfarin drug-drug interaction alerts: a study of healthcare downstream of {CPOE} alerts},
volume = {18 Suppl 1},
issn = {1527-974X},
shorttitle = {Provider and pharmacist responses to warfarin drug-drug interaction alerts},
doi = {10.1136/amiajnl-2011-000262},
abstract = {OBJECTIVE: To categorize the appropriateness of provider and pharmacist responses to warfarin critical drug-drug interaction (cDDI) alerts, assess responses and actions to the cDDI, and determine the occurrence of warfarin adverse drug events (ADE) after alerts.
DESIGN: An 18-month, retrospective study of acute care admissions at a single Veterans Affairs medical center using computerized provider order entry (CPOE).
MEASUREMENTS: Patients included had at least one warfarin cDDI alert. Chart reviews included baseline laboratory values and demographics, provider actions, patient outcomes, and associated factors, including other interacting medications and number of simultaneously processed alerts.
RESULTS: 137 admissions were included (133 unique patients). Amiodarone, vitamin E in a multivitamin, sulfamethoxazole, and levothyroxine accounted for 75\% of warfarin cDDI. Provider responses were clinically appropriate in 19.7\% of admissions and pharmacist responses were appropriate in 9.5\% of admissions. There were 50 ADE (36.6\% of admissions) with warfarin; 80\% were rated as having no or mild clinical effect. An increased number of non-critical alerts at the time of the reference cDDI alert was the only variable associated with an inappropriate provider response (p=0.01).
LIMITATIONS: This study was limited by being a retrospective review and the possibility of confounding variables, such as other interacting medications.
CONCLUSION: The large number of CPOE alerts may lead to inappropriate responses by providers and pharmacists. The high rate of ADE suggests a need for improved medication management systems for patients on warfarin. This study highlights the possibility of alert fatigue contributing to the high prevalence of inappropriate alert over-ride text responses.},
language = {eng},
journal = {Journal of the American Medical Informatics Association: JAMIA},
author = {Miller, Allison M and Boro, Maureen S and Korman, Nancy E and Davoren, J Ben},
month = dec,
year = {2011},
pmid = {22037888},
pmcid = {PMC3241165},
keywords = {Adult, Aged, Aged, 80 and over, Drug Interactions, Drug Therapy, Computer-Assisted, Hospitals, Veterans, Humans, Infant, Male, Medical Order Entry Systems, Medical Staff, Hospital, Middle Aged, Pharmacists, Reminder Systems, Retrospective Studies, United States, Warfarin},
pages = {i45--50}
}Hemangiomas revisited: the useful, the unusual and the new. Part 2: endangering hemangiomas and treatment. Restrepo, R., Palani, R., Cervantes, L. F., Duarte, A., Amjad, I., & Altman, N. R. Pediatric Radiology, 41(7):905--915, July, 2011.
doi abstract bibtex
doi abstract bibtex
Hemangiomas, although benign tumors, can when located in particular regions threaten vital structures or in certain clinical circumstances be associated with other abnormalities, carrying significant morbidity and mortality. We review these endangering hemangiomas. We also discuss briefly the treatment with emphasis on the recent use of propranolol.
@article{restrepo_hemangiomas_2011,
title = {Hemangiomas revisited: the useful, the unusual and the new. {Part} 2: endangering hemangiomas and treatment},
volume = {41},
issn = {1432-1998},
shorttitle = {Hemangiomas revisited},
doi = {10.1007/s00247-011-2090-7},
abstract = {Hemangiomas, although benign tumors, can when located in particular regions threaten vital structures or in certain clinical circumstances be associated with other abnormalities, carrying significant morbidity and mortality. We review these endangering hemangiomas. We also discuss briefly the treatment with emphasis on the recent use of propranolol.},
language = {eng},
number = {7},
journal = {Pediatric Radiology},
author = {Restrepo, Ricardo and Palani, Rajaneeshankar and Cervantes, Luisa F. and Duarte, Ana-Margarita and Amjad, Ibrahim and Altman, Nolan R.},
month = jul,
year = {2011},
pmid = {21607598},
keywords = {Child, Child, Preschool, Contrast Media, Diagnostic Imaging, Hemangioma, Humans, Infant, Infant, Newborn, Laser Therapy, Propranolol, Vasodilator Agents},
pages = {905--915}
}Prospective study of the frequency of hepatic hemangiomas in infants with multiple cutaneous infantile hemangiomas. Horii, K. A., Drolet, B. A., Frieden, I. J., Baselga, E., Chamlin, S. L., Haggstrom, A. N., Holland, K. E., Mancini, A. J., McCuaig, C. C., Metry, D. W., Morel, K. D., Newell, B. D., Nopper, A. J., Powell, J., Garzon, M. C., & Hemangioma Investigator Group Pediatric Dermatology, 28(3):245--253, June, 2011.
doi abstract bibtex
doi abstract bibtex
Multiple cutaneous infantile hemangiomas have been associated with hepatic hemangiomas. Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. The aim of this study was to determine the frequency with which hepatic hemangiomas occur in infants with five or more cutaneous infantile hemangiomas compared to those with one to four cutaneous infantile hemangiomas and to characterize the clinical features of these hepatic hemangiomas. A multicenter prospective study of children with cutaneous infantile hemangiomas was conducted at pediatric dermatology clinics at Hemangioma Investigator Groups sites in the United States, Canada, and Spain between October 2005 and December 2008. Data were collected, and abdominal ultrasonography was performed on infants younger than 6 months old with five or more cutaneous infantile hemangiomas and those with one to four cutaneous infantile hemangiomas. Twenty-four (16%) of the 151 infants with five or more cutaneous infantile hemangiomas had hepatic hemangiomas identified on abdominal ultrasound, versus none of the infants with fewer than five (p = 0.003). Two of the 24 infants with hepatic hemangiomas received treatment specifically for their hepatic hemangiomas. Infants with five or more cutaneous infantile hemangiomas have a statistically significantly greater frequency of hepatic hemangiomas than those with fewer than 5. These findings support the recommendation of five or more cutaneous infantile hemangiomas as a threshold for screening infants younger than 6 months old for hepatic hemangiomas but also demonstrate that the large majority of these infants with hepatic hemangiomas do not require treatment.
@article{horii_prospective_2011,
title = {Prospective study of the frequency of hepatic hemangiomas in infants with multiple cutaneous infantile hemangiomas},
volume = {28},
issn = {1525-1470},
doi = {10.1111/j.1525-1470.2011.01420.x},
abstract = {Multiple cutaneous infantile hemangiomas have been associated with hepatic hemangiomas. Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. The aim of this study was to determine the frequency with which hepatic hemangiomas occur in infants with five or more cutaneous infantile hemangiomas compared to those with one to four cutaneous infantile hemangiomas and to characterize the clinical features of these hepatic hemangiomas. A multicenter prospective study of children with cutaneous infantile hemangiomas was conducted at pediatric dermatology clinics at Hemangioma Investigator Groups sites in the United States, Canada, and Spain between October 2005 and December 2008. Data were collected, and abdominal ultrasonography was performed on infants younger than 6 months old with five or more cutaneous infantile hemangiomas and those with one to four cutaneous infantile hemangiomas. Twenty-four (16\%) of the 151 infants with five or more cutaneous infantile hemangiomas had hepatic hemangiomas identified on abdominal ultrasound, versus none of the infants with fewer than five (p = 0.003). Two of the 24 infants with hepatic hemangiomas received treatment specifically for their hepatic hemangiomas. Infants with five or more cutaneous infantile hemangiomas have a statistically significantly greater frequency of hepatic hemangiomas than those with fewer than 5. These findings support the recommendation of five or more cutaneous infantile hemangiomas as a threshold for screening infants younger than 6 months old for hepatic hemangiomas but also demonstrate that the large majority of these infants with hepatic hemangiomas do not require treatment.},
language = {eng},
number = {3},
journal = {Pediatric Dermatology},
author = {Horii, Kimberly A. and Drolet, Beth A. and Frieden, Ilona J. and Baselga, Eulalia and Chamlin, Sarah L. and Haggstrom, Anita N. and Holland, Kristen E. and Mancini, Anthony J. and McCuaig, Catherine C. and Metry, Denise W. and Morel, Kimberly D. and Newell, Brandon D. and Nopper, Amy J. and Powell, Julie and Garzon, Maria C. and {Hemangioma Investigator Group}},
month = jun,
year = {2011},
pmid = {21517952},
keywords = {Female, Hemangioma, Humans, Infant, Newborn, Liver Neoplasms, Male, Mass Screening, Prospective Studies, Risk Factors, Skin Neoplasms},
pages = {245--253}
}2010 (4)
Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid. Cilliers, K., Labadarios, D., Schaaf, H. S., Willemse, M., Maritz, J. S., Werely, C. J., Hussey, G., & Donald, P. R. Acta Paediatrica (Oslo, Norway: 1992), 99(5):705--710, May, 2010.
doi abstract bibtex
doi abstract bibtex
AIM: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens. METHODS: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements. RESULTS: Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p \textless 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations (\textless6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004). CONCLUSION: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.
@article{ cilliers_pyridoxal-5-phosphate_2010,
title = {Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid},
volume = {99},
issn = {1651-2227},
doi = {10.1111/j.1651-2227.2010.01696.x},
abstract = {AIM: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens.
METHODS: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements.
RESULTS: Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p {\textless} 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations ({\textless}6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004).
CONCLUSION: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.},
language = {eng},
number = {5},
journal = {Acta Paediatrica (Oslo, Norway: 1992)},
author = {Cilliers, K. and Labadarios, D. and Schaaf, H. S. and Willemse, M. and Maritz, J. S. and Werely, C. J. and Hussey, G. and Donald, P. R.},
month = {May},
year = {2010},
pmid = {20146723},
keywords = {AIDS-Related Opportunistic Infections, Adolescent, Antitubercular Agents, Child, Child, Preschool, Female, Genotype, HIV Infections, Humans, Infant, Isoniazid, Male, Pyridoxal Phosphate, South Africa, Tuberculosis},
pages = {705--710}
}The role of Power Doppler ultrasonography in comparison with biological markers in the evaluation of disease activity in Juvenile Idiopathic Arthritis. Spârchez, M., Fodor, D., & Miu, N. Medical Ultrasonography, 12(2):97--103, June, 2010.
abstract bibtex
abstract bibtex
OBJECTIVE: To evaluate the performance of Power Doppler Ultrasonography (PDUS) compared with biological markers, in the assessment of disease activity in children with Juvenile Idiopathic Arthritis (JIA). METHODS: Forty hospital visits were studied comprising 32 patients with JIA, during one year of follow-up. Each patient underwent clinical, laboratory and ultrasound (PDUS) evaluation. The physician global assessment score on the visual analog scale (PhGA) was used as a standard for assessing disease activity, based on previous studies. The PDUS signal was scored according to a semiquantitative four grade scale (0-3). RESULTS: PDUS assessment of synovial vascularisation was more sensitive than erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) in identification of the active disease: 90.4% vs. 57% and 28.5% respectively. CRP had a higher specificity (94%) in comparison with PDUS (89.5%). A significant association between clinical examination (PhGA) and PDUS score or ESR was found. Kappa statistics revealed a high level of agreement between PhGA and PDUS score (k=0.799) and a low level of agreement between PhGA and biological markers (k=0.356 and k=0.225 respectively). Patients with higher PDUS score (\textgreateror=2), ESR\textgreateror=30 mm/h or CRP\textgreateror=2 mg/dl were more likely to have active disease. CONCLUSION: Laboratory tests used today are not sufficiently sensitive for the prediction of active disease. PDUS assessment of synovial vascularisation is a technique with good sensitivity and specificity, thus it may be a beneficial criteria for evaluating disease activity in JIA, completing conventional clinical examination.
@article{sparchez_role_2010,
title = {The role of {Power} {Doppler} ultrasonography in comparison with biological markers in the evaluation of disease activity in {Juvenile} {Idiopathic} {Arthritis}},
volume = {12},
issn = {1844-4172},
abstract = {OBJECTIVE: To evaluate the performance of Power Doppler Ultrasonography (PDUS) compared with biological markers, in the assessment of disease activity in children with Juvenile Idiopathic Arthritis (JIA).
METHODS: Forty hospital visits were studied comprising 32 patients with JIA, during one year of follow-up. Each patient underwent clinical, laboratory and ultrasound (PDUS) evaluation. The physician global assessment score on the visual analog scale (PhGA) was used as a standard for assessing disease activity, based on previous studies. The PDUS signal was scored according to a semiquantitative four grade scale (0-3).
RESULTS: PDUS assessment of synovial vascularisation was more sensitive than erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) in identification of the active disease: 90.4\% vs. 57\% and 28.5\% respectively. CRP had a higher specificity (94\%) in comparison with PDUS (89.5\%). A significant association between clinical examination (PhGA) and PDUS score or ESR was found. Kappa statistics revealed a high level of agreement between PhGA and PDUS score (k=0.799) and a low level of agreement between PhGA and biological markers (k=0.356 and k=0.225 respectively). Patients with higher PDUS score ({\textgreater}or=2), ESR{\textgreater}or=30 mm/h or CRP{\textgreater}or=2 mg/dl were more likely to have active disease.
CONCLUSION: Laboratory tests used today are not sufficiently sensitive for the prediction of active disease. PDUS assessment of synovial vascularisation is a technique with good sensitivity and specificity, thus it may be a beneficial criteria for evaluating disease activity in JIA, completing conventional clinical examination.},
language = {eng},
number = {2},
journal = {Medical Ultrasonography},
author = {Spârchez, Mihaela and Fodor, Daniela and Miu, Nicolae},
month = jun,
year = {2010},
pmid = {21173935},
keywords = {Adolescent, Arthritis, Juvenile, Biomarkers, Blood Sedimentation, C-Reactive Protein, Chi-Square Distribution, Child, Child, Preschool, Female, Humans, Infant, Male, Predictive Value of Tests, Sensitivity and Specificity, Ultrasonography, Doppler, Young Adult},
pages = {97--103}
}Termination of pregnancy following prenatal diagnosis in France: how severe are the foetal anomalies?. Dommergues, M., Mandelbrot, L., Mahieu-Caputo, D., Boudjema, N., & Durand-Zaleski, I. Prenatal diagnosis, 30(6):531--9, June, 2010.
Paper doi abstract bibtex
Paper doi abstract bibtex OBJECTIVE: To determine how severe were the conditions leading to termination of pregnancy for foetal anomaly (TOPFA) in France. METHODS: Detailed indications for TOPFA were extracted from medical charts. RESULTS: Of 2465 completed records, indications were: chromosomal anomalies n = 963 (39.1%), malformations of a single organ without chromosomal or genetic aetiologies n = 898 (36.4%), multiple malformations without chromosomal or genetic aetiologies n = 238 (9.7%), obstetrical complications n = 161 (6.5%), non-chromosomal genetic diseases n = 158 (6.4%), foetal infections n = 21 (0.9%), unexplained severe oligohydramnios n = 20 (0.8%), foetal exposure to teratogenic agents n = 6. Overall, 33.3% of anomalies were lethal (e.g. anencephaly), 25.2% were expected to result in isolated mental retardation (e.g. Down) and 35.1% in substantial handicap (e.g. myelomeningocele). In 6.4% of cases, the anomaly was either of late onset (e.g. Huntington's disease) or with uncertain prognosis (e.g. agenesis of corpus callosum) or severity was debatable (e.g. single limb agenesis, sickle cell disease). CONCLUSIONS: Although there is no indisputable definition of which anomalies are 'severe', 93.6% of the decisions to terminate the pregnancy were made by women and professionals in reaction to anomalies which clearly were lethal or would lead to substantial physical and/or mental disabilities.
@article{Dommergues2010,
abstract = {OBJECTIVE: To determine how severe were the conditions leading to termination of pregnancy for foetal anomaly (TOPFA) in France. METHODS: Detailed indications for TOPFA were extracted from medical charts. RESULTS: Of 2465 completed records, indications were: chromosomal anomalies n = 963 (39.1\%), malformations of a single organ without chromosomal or genetic aetiologies n = 898 (36.4\%), multiple malformations without chromosomal or genetic aetiologies n = 238 (9.7\%), obstetrical complications n = 161 (6.5\%), non-chromosomal genetic diseases n = 158 (6.4\%), foetal infections n = 21 (0.9\%), unexplained severe oligohydramnios n = 20 (0.8\%), foetal exposure to teratogenic agents n = 6. Overall, 33.3\% of anomalies were lethal (e.g. anencephaly), 25.2\% were expected to result in isolated mental retardation (e.g. Down) and 35.1\% in substantial handicap (e.g. myelomeningocele). In 6.4\% of cases, the anomaly was either of late onset (e.g. Huntington's disease) or with uncertain prognosis (e.g. agenesis of corpus callosum) or severity was debatable (e.g. single limb agenesis, sickle cell disease). CONCLUSIONS: Although there is no indisputable definition of which anomalies are 'severe', 93.6\% of the decisions to terminate the pregnancy were made by women and professionals in reaction to anomalies which clearly were lethal or would lead to substantial physical and/or mental disabilities.},
author = {Dommergues, Marc and Mandelbrot, Laurent and Mahieu-Caputo, Dominique and Boudjema, Noel and Durand-Zaleski, Isabelle},
doi = {10.1002/pd.2510},
file = {:C$\backslash$:/Users/emnicolas/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Dommergues et al. - 2010 - Termination of pregnancy following prenatal diagnosis in France how severe are the foetal anomalies.pdf:pdf},
issn = {1097-0223},
journal = {Prenatal diagnosis},
keywords = {Abortion,Congenital Abnormalities,Congenital Abnormalities: diagnosis,Congenital Abnormalities: epidemiology,Congenital Abnormalities: etiology,Counseling,Counseling: statistics \& numerical data,Counseling: utilization,Eugenic,Eugenic: ethics,Eugenic: statistics \& numerical data,Eugenic: utilization,Female,France,France: epidemiology,Geography,Gestational Age,Humans,Infant,Live Birth,Live Birth: epidemiology,Newborn,Pregnancy,Prenatal Diagnosis,Prenatal Diagnosis: statistics \& numerical data,Prenatal Diagnosis: utilization,Severity of Illness Index},
month = jun,
number = {6},
pages = {531--9},
pmid = {20509152},
title = {{Termination of pregnancy following prenatal diagnosis in France: how severe are the foetal anomalies?}},
url = {http://onlinelibrary.wiley.com/doi/10.1002/pd.2510/full http://www.ncbi.nlm.nih.gov/pubmed/20509152},
volume = {30},
year = {2010}
}Impact of pre-conception health care: evaluation of a social determinants focused intervention. Livingood, W. C., Brady, C., Pierce, K., Atrash, H., Hou, T., & Bryant, T. Maternal and Child Health Journal, 14(3):382--391, May, 2010.
doi abstract bibtex
doi abstract bibtex
The purpose of this study was to evaluate the outcomes of the social determinants component of a multiple determinants model of pre- and inter-conception care. Health department vital statistics and infectious disease data on birth and factors influencing birth outcomes were analyzed for participants in a program designed to mitigate the effects of social class and stress in contrast to a matched comparison group and other relevant populations. The program showed promising results related to reducing infant mortality and reducing other high-risk factors for poor birth outcomes, including low birth weight and sexually transmitted disease. Social determinant interventions, designed to mitigate the impact of social class and stress, should be considered with efforts to reduce infant mortality, particularly the disparities associated with infant mortality. Additional research should be conducted to refine replicable social determinant focused interventions and confirm and generalize these results.
@article{livingood_impact_2010,
title = {Impact of pre-conception health care: evaluation of a social determinants focused intervention},
volume = {14},
issn = {1573-6628},
shorttitle = {Impact of pre-conception health care},
doi = {10.1007/s10995-009-0471-4},
abstract = {The purpose of this study was to evaluate the outcomes of the social determinants component of a multiple determinants model of pre- and inter-conception care. Health department vital statistics and infectious disease data on birth and factors influencing birth outcomes were analyzed for participants in a program designed to mitigate the effects of social class and stress in contrast to a matched comparison group and other relevant populations. The program showed promising results related to reducing infant mortality and reducing other high-risk factors for poor birth outcomes, including low birth weight and sexually transmitted disease. Social determinant interventions, designed to mitigate the impact of social class and stress, should be considered with efforts to reduce infant mortality, particularly the disparities associated with infant mortality. Additional research should be conducted to refine replicable social determinant focused interventions and confirm and generalize these results.},
language = {eng},
number = {3},
journal = {Maternal and Child Health Journal},
author = {Livingood, William C. and Brady, Carol and Pierce, Kimberly and Atrash, Hani and Hou, Tao and Bryant, Thomas},
month = may,
year = {2010},
pmid = {19662521},
keywords = {African Americans, Birth Weight, Case Management, Chi-Square Distribution, Female, Florida, Health Status Disparities, Healthcare Disparities, Humans, Infant Mortality, Infant, Newborn, Models, Organizational, Organizational Objectives, Preconception Care, Pregnancy, Pregnancy Outcome, Program Evaluation, Retrospective Studies, Sexually Transmitted Diseases, Social Class, Socioeconomic Factors, Stress, Psychological},
pages = {382--391}
}2009 (4)
Isoniazid plasma concentrations in a cohort of South African children with tuberculosis: implications for international pediatric dosing guidelines. McIlleron, H., Willemse, M., Werely, C. J., Hussey, G. D., Schaaf, Simon, H., Smith, P. J., & Donald, P. R. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 48(11):1547--1553, June, 2009.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: In most countries with a high burden of tuberculosis, children with tuberculosis are prescribed isoniazid at dosages of 4-6 mg/kg/day, as recommended by international authorities. METHODS: We studied isoniazid concentrations in 56 hospitalized children (median age, 3.22 years; interquartile range [IQR], 1.58-5.38 years) who received isoniazid daily (median dosage, 5.01 mg/kg/day; range, 2.94-15.58 mg/kg/day) as part of antituberculosis treatment. At 1 and 4 months after initiation of treatment, isoniazid concentrations were measured in plasma samples at 0.75, 1.5, 3, 4, and 6 h after a treatment dose, to describe pharmacokinetic measures by using noncompartmental analysis. The effects of dose in milogram per kilogram, acetylator genotype, age, sex, and clinical diagnosis of kwashiorkor and human immunodeficiency virus (HIV) infection on isoniazid concentrations were evaluated. RESULTS: Median peak concentrations of isoniazid in children prescribed a dose of 4-6 mg/kg were 58% lower than those in children prescribed a dose of 8-10 mg/kg (2.39 mg/L [IQR, 1.59-3.40] vs. 5.71 mg/L [IQR, 4.74-7.62]). Peak concentrations were \textless3 mg/L in 70% of children prescribed a dose of 4-6 mg/kg. In contrast, children prescribed a dose of 8-12 mg/kg achieved peak concentrations approximating those in adults treated with 300 mg of isoniazid daily. Intermediate or fast acetylator genotype independently predicted a 38% (95% confidence interval [CI], 21%-51%) reduction in peak concentrations, compared with the slow-acetylator genotype. Each 1-mg/kg increase in the dose and each year increase in age were associated with increases in peak concentrations of 21% (95% CI, 16%-25%) and 6% (95% CI, 3%-10%), respectively. CONCLUSIONS: Younger children require higher doses of isoniazid per kilogram of body weight to achieve isoniazid concentrations similar to those in adults. A daily isoniazid dose of 8-12 mg/kg should be recommended.
@article{ mcilleron_isoniazid_2009,
title = {Isoniazid plasma concentrations in a cohort of {South} {African} children with tuberculosis: implications for international pediatric dosing guidelines},
volume = {48},
issn = {1537-6591},
shorttitle = {Isoniazid plasma concentrations in a cohort of {South} {African} children with tuberculosis},
doi = {10.1086/598192},
abstract = {BACKGROUND: In most countries with a high burden of tuberculosis, children with tuberculosis are prescribed isoniazid at dosages of 4-6 mg/kg/day, as recommended by international authorities.
METHODS: We studied isoniazid concentrations in 56 hospitalized children (median age, 3.22 years; interquartile range [IQR], 1.58-5.38 years) who received isoniazid daily (median dosage, 5.01 mg/kg/day; range, 2.94-15.58 mg/kg/day) as part of antituberculosis treatment. At 1 and 4 months after initiation of treatment, isoniazid concentrations were measured in plasma samples at 0.75, 1.5, 3, 4, and 6 h after a treatment dose, to describe pharmacokinetic measures by using noncompartmental analysis. The effects of dose in milogram per kilogram, acetylator genotype, age, sex, and clinical diagnosis of kwashiorkor and human immunodeficiency virus (HIV) infection on isoniazid concentrations were evaluated.
RESULTS: Median peak concentrations of isoniazid in children prescribed a dose of 4-6 mg/kg were 58% lower than those in children prescribed a dose of 8-10 mg/kg (2.39 mg/L [IQR, 1.59-3.40] vs. 5.71 mg/L [IQR, 4.74-7.62]). Peak concentrations were {\textless}3 mg/L in 70% of children prescribed a dose of 4-6 mg/kg. In contrast, children prescribed a dose of 8-12 mg/kg achieved peak concentrations approximating those in adults treated with 300 mg of isoniazid daily. Intermediate or fast acetylator genotype independently predicted a 38% (95% confidence interval [CI], 21%-51%) reduction in peak concentrations, compared with the slow-acetylator genotype. Each 1-mg/kg increase in the dose and each year increase in age were associated with increases in peak concentrations of 21% (95% CI, 16%-25%) and 6% (95% CI, 3%-10%), respectively.
CONCLUSIONS: Younger children require higher doses of isoniazid per kilogram of body weight to achieve isoniazid concentrations similar to those in adults. A daily isoniazid dose of 8-12 mg/kg should be recommended.},
language = {eng},
number = {11},
journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
author = {McIlleron, Helen and Willemse, Marianne and Werely, Cedric J. and Hussey, Gregory D. and Schaaf, H. Simon and Smith, Peter J. and Donald, Peter R.},
month = {June},
year = {2009},
pmid = {19392636},
keywords = {Antitubercular Agents, Child, Preschool, Female, Humans, Infant, Isoniazid, Male, Plasma, South Africa, Tuberculosis},
pages = {1547--1553}
}Brominated flame retardants in children's toys: concentration, composition, and children's exposure and risk assessment. Chen, S., Ma, Y., Wang, J., Chen, D., Luo, X., & Mai, B. Environmental science & technology, 43(11):4200--6, June, 2009.
Paper abstract bibtex
Paper abstract bibtex Brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), decabromodiphenyl ethane (DBDPE), and polybrominated biphenyls (PBBs) were found in children's toys purchased from South China. The median BFR concentrations in the hard plastic toys were 53,000, 5540 ng/g, 101.1 ng/g, and 27.9 ng/g, fortotal PBDEs, DBDPE, BTBPE, and PBBs, respectively,which were notably higher than values in other toys. The PBDE concentrations were below the threshold limit (1000 ppm) required bythe European Commission's Restriction of Hazardous Substances (RoHS) and Waste Electrical and Electronic Equipment (WEEE) directives in all of the toys, except for one hard plastic toy with a total PBDE concentration of 5,344,000 ng/g. The BFR profiles in the toys were consistent with the patterns of their current production and consumption in China, where PBDEs, specifically decaBDE product, were the dominant BFR, followed by the emerging DBDPE. The relatively high concentrations of octa- and nonaBDEs in the foam toys and the results of principal component analysis (PCA) may suggest the decomposition of highly brominated BDEs during the manufacturing processes of the toys. Daily total PBDE exposures associated with toys via inhalation, mouthing, dermal contact, and oral ingestion ranged from 82.6 to 8992 pg/kg bw-day for children of 3 months to 14 years of age. Higher exposures, predominantly contributed through the mouthing pathway, were observed for infants and toddlers than for the other subgroups. In most cases, children's BFR exposure via the toys likely accounts for a small proportion of their daily BFR exposure, and the hazard quotients for noncancer risk evaluation were far below 1. To the author's knowledge, this is the first study to examine the concentrations of BFRs in toys, and the potential exposures to children.
@article{chen_brominated_2009,
title = {Brominated flame retardants in children's toys: concentration, composition, and children's exposure and risk assessment.},
volume = {43},
issn = {0013-936X},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19569352},
abstract = {Brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), decabromodiphenyl ethane (DBDPE), and polybrominated biphenyls (PBBs) were found in children's toys purchased from South China. The median BFR concentrations in the hard plastic toys were 53,000, 5540 ng/g, 101.1 ng/g, and 27.9 ng/g, fortotal PBDEs, DBDPE, BTBPE, and PBBs, respectively,which were notably higher than values in other toys. The PBDE concentrations were below the threshold limit (1000 ppm) required bythe European Commission's Restriction of Hazardous Substances (RoHS) and Waste Electrical and Electronic Equipment (WEEE) directives in all of the toys, except for one hard plastic toy with a total PBDE concentration of 5,344,000 ng/g. The BFR profiles in the toys were consistent with the patterns of their current production and consumption in China, where PBDEs, specifically decaBDE product, were the dominant BFR, followed by the emerging DBDPE. The relatively high concentrations of octa- and nonaBDEs in the foam toys and the results of principal component analysis (PCA) may suggest the decomposition of highly brominated BDEs during the manufacturing processes of the toys. Daily total PBDE exposures associated with toys via inhalation, mouthing, dermal contact, and oral ingestion ranged from 82.6 to 8992 pg/kg bw-day for children of 3 months to 14 years of age. Higher exposures, predominantly contributed through the mouthing pathway, were observed for infants and toddlers than for the other subgroups. In most cases, children's BFR exposure via the toys likely accounts for a small proportion of their daily BFR exposure, and the hazard quotients for noncancer risk evaluation were far below 1. To the author's knowledge, this is the first study to examine the concentrations of BFRs in toys, and the potential exposures to children.},
number = {11},
journal = {Environmental science \& technology},
author = {Chen, She-Jun and Ma, Yun-Juan and Wang, Jing and Chen, Da and Luo, Xiao-Jun and Mai, Bi-Xian},
month = jun,
year = {2009},
pmid = {19569352},
keywords = {Adolescent, Brominated, Brominated: chemistry, Brominated: toxicity, Child, Environmental Exposure, Environmental Pollutants, Environmental Pollutants: chemistry, Environmental Pollutants: toxicity, Flame Retardants: analysis, Flame Retardants: toxicity, Flame retardants, Humans, Hydrocarbons, Infant, Play and Playthings, Preschool, Risk Factors, ffr, frelec, use},
pages = {4200--6}
}Conditions masquerading as infantile haemangioma: Part 2. Frieden, I. J., Rogers, M., & Garzon, M. C. The Australasian Journal of Dermatology, 50(3):153--168; quiz 169--170, August, 2009.
doi abstract bibtex
doi abstract bibtex
Infantile haemangiomas are among the most common growths during infancy. Their rapid growth during infancy and vascularity can easily cause confusion with other, less common growths. Part I focussed on other vascular anomalies that can mimic infantile haemangiomas. Part II emphasizes benign growths and malignant conditions that can also cause diagnostic confusion.
@article{frieden_conditions_2009,
title = {Conditions masquerading as infantile haemangioma: {Part} 2},
volume = {50},
issn = {1440-0960},
shorttitle = {Conditions masquerading as infantile haemangioma},
doi = {10.1111/j.1440-0960.2009.00529_1.x},
abstract = {Infantile haemangiomas are among the most common growths during infancy. Their rapid growth during infancy and vascularity can easily cause confusion with other, less common growths. Part I focussed on other vascular anomalies that can mimic infantile haemangiomas. Part II emphasizes benign growths and malignant conditions that can also cause diagnostic confusion.},
language = {eng},
number = {3},
journal = {The Australasian Journal of Dermatology},
author = {Frieden, Ilona J. and Rogers, Maureen and Garzon, Maria C.},
month = aug,
year = {2009},
pmid = {19659975},
keywords = {Arteriovenous Malformations, Dermoid Cyst, Diagnosis, Differential, Female, Fibrosarcoma, Hemangioma, Histiocytosis, Langerhans-Cell, Humans, Infant, Infant, Newborn, Male, Rhabdomyosarcoma, Skin Neoplasms, Telangiectasis, vascular malformations},
pages = {153--168; quiz 169--170}
}A targeted population carrier screening program for severe and frequent genetic diseases in Israel. Zlotogora, J., Carmi, R., Lev, B., & Shalev, S., A. Eur J Hum Genet, 17(5):591-597, 2009.
Paper Website abstract bibtex
Paper Website abstract bibtex A national carrier screening program targeted at communities in which severe genetic diseases are present with a frequency higher than 1/1000 live births, has been in existence in Israel since 2002. Within the communities at risk, carrier screening is voluntary whereas genetic counseling and testing is provided free of charge. During the first 5 years of the program more than 13 000 tests were performed, and at the end of 2007 it was offered in 35 different localities/communities for a total of 36 diseases. Many of the couples identified to be at risk opted for prenatal diagnosis and in two cases an affected pregnancy was terminated. In some cases the couples declined prenatal diagnosis and two of those families gave birth to an affected child. Based on the experience learnt from this targeted screening program it appears that a knowledge-based, voluntary screening program operated within the community is an effective way to provide genetic services and test referrals. The community program directed toward couples in their reproductive period does not seem to have led to stigmatization at either the individual or the community level.
@article{
title = {A targeted population carrier screening program for severe and frequent genetic diseases in Israel},
type = {article},
year = {2009},
identifiers = {[object Object]},
keywords = {Child,Female,Genetic Diseases, Inborn/*diagnosis/*genetics,Genetic Testing/*methods,Heterozygote Detection/*methods,Humans,Infant, Newborn,Israel,Neonatal Screening,Pregnancy,Prenatal Diagnosis,Program Evaluation},
pages = {591-597},
volume = {17},
websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19107146},
edition = {2008/12/25},
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notes = {<m:note>Zlotogora, Joel<m:linebreak/>Carmi, Rivka<m:linebreak/>Lev, Boaz<m:linebreak/>Shalev, Stavit A<m:linebreak/>England<m:linebreak/>European journal of human genetics : EJHG<m:linebreak/>ejhg2008241<m:linebreak/>Eur J Hum Genet. 2009 May;17(5):591-7. Epub 2008 Dec 24.</m:note>},
abstract = {A national carrier screening program targeted at communities in which severe genetic diseases are present with a frequency higher than 1/1000 live births, has been in existence in Israel since 2002. Within the communities at risk, carrier screening is voluntary whereas genetic counseling and testing is provided free of charge. During the first 5 years of the program more than 13 000 tests were performed, and at the end of 2007 it was offered in 35 different localities/communities for a total of 36 diseases. Many of the couples identified to be at risk opted for prenatal diagnosis and in two cases an affected pregnancy was terminated. In some cases the couples declined prenatal diagnosis and two of those families gave birth to an affected child. Based on the experience learnt from this targeted screening program it appears that a knowledge-based, voluntary screening program operated within the community is an effective way to provide genetic services and test referrals. The community program directed toward couples in their reproductive period does not seem to have led to stigmatization at either the individual or the community level.},
bibtype = {article},
author = {Zlotogora, J and Carmi, R and Lev, B and Shalev, S A},
journal = {Eur J Hum Genet},
number = {5}
}2008 (7)
No association between routinely recorded infections in early life and subsequent risk of childhood-onset Type 1 diabetes: a matched case-control study using the UK General Practice Research Database. Cardwell, C. R., Carson, D. J., & Patterson, C. C. Diabetic Medicine: A Journal of the British Diabetic Association, 25(3):261--267, March, 2008.
doi abstract bibtex
doi abstract bibtex
AIMS: To determine whether children with infections in early life (recorded routinely in general practice) have a reduced risk of Type 1 diabetes, as would be expected from the hygiene hypothesis. METHODS: Children with Type 1 diabetes and up to 20 matched (on year of birth, sex and region) control subjects were selected from a cohort of children born in the UK at General Practice Research Database practices. For each child, the frequency of general practitioner consultations for infections and prescriptions for antibiotics in the first year of life were determined. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using conditional logistic regression. RESULTS: The main analysis included 367 case and 4579 matched control subjects. There was no evidence of any reduction in the subsequent risk of Type 1 diabetes in children with at least one infection in the first year of life (OR = 1.03, 95%CI 0.79, 1.34) or in children prescribed antibiotics in the first year of life (OR = 1.03, 95%CI 0.82, 1.29). Further analyses also revealed little evidence of a difference in subsequent risk of Type 1 diabetes after different types of infection in the first year of life (including gastrointestinal, conjunctivitis, otitis media and upper and lower respiratory tract). Analyses of infections in the first 2 years of life reached similar conclusions. CONCLUSIONS: This study provides no evidence of an association between infections in early life and subsequent risk of childhood-onset Type 1 diabetes and therefore does not support the hygiene hypothesis.
@article{cardwell_no_2008,
title = {No association between routinely recorded infections in early life and subsequent risk of childhood-onset {Type} 1 diabetes: a matched case-control study using the {UK} {General} {Practice} {Research} {Database}},
volume = {25},
issn = {1464-5491},
shorttitle = {No association between routinely recorded infections in early life and subsequent risk of childhood-onset {Type} 1 diabetes},
doi = {10.1111/j.1464-5491.2007.02351.x},
abstract = {AIMS: To determine whether children with infections in early life (recorded routinely in general practice) have a reduced risk of Type 1 diabetes, as would be expected from the hygiene hypothesis.
METHODS: Children with Type 1 diabetes and up to 20 matched (on year of birth, sex and region) control subjects were selected from a cohort of children born in the UK at General Practice Research Database practices. For each child, the frequency of general practitioner consultations for infections and prescriptions for antibiotics in the first year of life were determined. Odds ratios (ORs) and 95\% confidence intervals (95\%CIs) were calculated using conditional logistic regression.
RESULTS: The main analysis included 367 case and 4579 matched control subjects. There was no evidence of any reduction in the subsequent risk of Type 1 diabetes in children with at least one infection in the first year of life (OR = 1.03, 95\%CI 0.79, 1.34) or in children prescribed antibiotics in the first year of life (OR = 1.03, 95\%CI 0.82, 1.29). Further analyses also revealed little evidence of a difference in subsequent risk of Type 1 diabetes after different types of infection in the first year of life (including gastrointestinal, conjunctivitis, otitis media and upper and lower respiratory tract). Analyses of infections in the first 2 years of life reached similar conclusions.
CONCLUSIONS: This study provides no evidence of an association between infections in early life and subsequent risk of childhood-onset Type 1 diabetes and therefore does not support the hygiene hypothesis.},
language = {eng},
number = {3},
journal = {Diabetic Medicine: A Journal of the British Diabetic Association},
author = {Cardwell, C. R. and Carson, D. J. and Patterson, C. C.},
month = mar,
year = {2008},
pmid = {18201209},
keywords = {Adolescent, Case-Control Studies, Child, Child, Preschool, Diabetes Mellitus, Type 1, Great Britain, Humans, Infant, databases as topic, infection},
pages = {261--267}
}Conscientious objection: a potential neonatal nursing response to care orders that cause suffering at the end of life? Study of a concept. Catlin, A., Armigo, C., Volat, D., Vale, E., Hadley, Ann, M., Gong, W., Bassir, R., & Anderson, K. Neonatal network: NN, 27(2):101--108, April, 2008.
Paper doi abstract bibtex
Paper doi abstract bibtex This article is an exploratory effort meant to solicit and provoke dialog. Conscientious objection is proposed as a potential response to the moral distress experienced by neonatal nurses. The most commonly reported cause of distress for all nurses is following orders to support patients at the end of their lives with advanced technology when palliative or comfort care would be more humane. Nurses report that they feel they are harming patients or causing suffering when they could be comforting instead. We examined the literature on moral distress, futility, and the concept of conscientious objection from the perspective of the nurse's potential response to performing advanced technologic interventions for the dying patient. We created a small pilot study to engage in clinical verification of the use of our concept of conscientious objection. Data from 66 neonatal intensive care and pediatric intensive care unit nurses who responded in a one-month period are reported here. Interest in conscientious objection to care that causes harm or suffering was very high. This article reports the analysis of conscientious objection use in neonatal care.
@article{ catlin_conscientious_2008-1,
title = {Conscientious objection: a potential neonatal nursing response to care orders that cause suffering at the end of life? Study of a concept},
volume = {27},
issn = {0730-0832},
shorttitle = {Conscientious objection},
url = {http://www.sonoma.edu/users/c/catlin/conscientious%20objection.pdf},
doi = {10.1891/0730-0832.27.2.101},
abstract = {This article is an exploratory effort meant to solicit and provoke dialog. Conscientious objection is proposed as a potential response to the moral distress experienced by neonatal nurses. The most commonly reported cause of distress for all nurses is following orders to support patients at the end of their lives with advanced technology when palliative or comfort care would be more humane. Nurses report that they feel they are harming patients or causing suffering when they could be comforting instead. We examined the literature on moral distress, futility, and the concept of conscientious objection from the perspective of the nurse's potential response to performing advanced technologic interventions for the dying patient. We created a small pilot study to engage in clinical verification of the use of our concept of conscientious objection. Data from 66 neonatal intensive care and pediatric intensive care unit nurses who responded in a one-month period are reported here. Interest in conscientious objection to care that causes harm or suffering was very high. This article reports the analysis of conscientious objection use in neonatal care.},
language = {eng},
number = {2},
journal = {Neonatal network: {NN}},
author = {Catlin, Anita and Armigo, Christine and Volat, Deborah and Vale, Elnora and Hadley, Mary Ann and Gong, Wendy and Bassir, Ranginah and Anderson, Kelly},
month = {April},
year = {2008},
pmid = {18431964},
keywords = {Attitude of Health Personnel, Conflict (Psychology), Conscience, Health Knowledge, Attitudes, Practice, Humans, Infant, Newborn, Intensive Care, Neonatal, Medical Futility, Models, Nursing, Morals, Neonatal Nursing, Nurse's Role, Nursing Methodology Research, Nursing Staff, Hospital, Palliative Care, Patient Advocacy, Pilot Projects, Questionnaires, Stress, Psychological},
pages = {101--108}
}Sleep hygiene for children with neurodevelopmental disabilities. Jan, J., E., Owens, J., a., Weiss, M., D., Johnson, K., P., Wasdell, M., B., Freeman, R., D., & Ipsiroglu, O., S. Pediatrics, 122(6):1343-50, 12, 2008.
Paper abstract bibtex
Paper abstract bibtex Sleep disturbances in children with neurodevelopmental disabilities are common and have a profound effect on the quality of life of the child, as well as the entire family. Although interventions for sleep problems in these children often involve a combination of behavioral and pharmacologic strategies, the first line of treatment is the promotion of improved sleep habits or "hygiene." Despite the importance of sleep-hygiene principles, defined as basic optimal environmental, scheduling, sleep-practice, and physiologic sleep-promoting factors, clinicians often lack appropriate knowledge and skills to implement them. In addition, sleep-hygiene practices may need to be modified and adapted for this population of children and are often more challenging to implement compared with their healthy counterparts. This first comprehensive, multidisciplinary review of sleep hygiene for children with disabilities presents the rationale for incorporating these measures in their treatment, outlines both general and specific sleep-promotion practices, and discusses problem-solving strategies for implementing them in a variety of clinical practice settings.
@article{
id = {d3b99cc5-13c9-3545-885b-7a4dc0d6a45b},
title = {Sleep hygiene for children with neurodevelopmental disabilities.},
type = {article},
year = {2008},
identifiers = {[object Object]},
keywords = {Caregivers,Caregivers: psychology,Child,Child Care,Child Care: methods,Child, Preschool,Developmental Disabilities,Developmental Disabilities: complications,Developmental Disabilities: diagnosis,Environment,Female,Humans,Infant,Male,Mental Disorders,Mental Disorders: complications,Mental Disorders: diagnosis,Mental Health,Parent-Child Relations,Pediatrics,Pediatrics: standards,Pediatrics: trends,Quality of Life,Risk Assessment,Severity of Illness Index,Sleep Disorders,Sleep Disorders: etiology,Sleep Disorders: rehabilitation,Stress, Psychological},
created = {2012-06-13T03:54:21.000Z},
pages = {1343-50},
volume = {122},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/19047255},
month = {12},
accessed = {2010-10-11},
file_attached = {true},
profile_id = {fe7067eb-58b8-34c6-b8cd-6717fdf7605c},
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confirmed = {true},
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client_data = {"desktop_id":"f412cd4a-20b9-4037-8a18-be3d160659b2"},
abstract = {Sleep disturbances in children with neurodevelopmental disabilities are common and have a profound effect on the quality of life of the child, as well as the entire family. Although interventions for sleep problems in these children often involve a combination of behavioral and pharmacologic strategies, the first line of treatment is the promotion of improved sleep habits or "hygiene." Despite the importance of sleep-hygiene principles, defined as basic optimal environmental, scheduling, sleep-practice, and physiologic sleep-promoting factors, clinicians often lack appropriate knowledge and skills to implement them. In addition, sleep-hygiene practices may need to be modified and adapted for this population of children and are often more challenging to implement compared with their healthy counterparts. This first comprehensive, multidisciplinary review of sleep hygiene for children with disabilities presents the rationale for incorporating these measures in their treatment, outlines both general and specific sleep-promotion practices, and discusses problem-solving strategies for implementing them in a variety of clinical practice settings.},
bibtype = {article},
author = {Jan, James E and Owens, Judith a and Weiss, Margaret D and Johnson, Kyle P and Wasdell, Michael B and Freeman, Roger D and Ipsiroglu, Osman S},
journal = {Pediatrics},
number = {6}
}Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children. Orton, H., D., Szabo, N., J., Clare-Salzler, M., & Norris, J., M. Eur J Clin Nutr, 62(6):733-738, 2008.
Website abstract bibtex
Website abstract bibtex OBJECTIVE: We conducted a dietary validation study in youth aged 1-11 years by comparing dietary intake of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) as assessed by a parent-completed semiquantitative food frequency questionnaire (FFQ) over time to erythrocyte membrane composition of the same fatty acids. DESIGN: The study population included youth aged 1-11 years who were participants in the Diabetes Autoimmunity Study in the Young (DAISY), a longitudinal study in Denver, Colorado that is following a cohort of youth at risk for developing type I diabetes. Four hundred and four children who had erythrocyte membrane fatty acid data matched to an FFQ corresponding to the same time frame for a total of 917 visits (matches) were included. PUFA intake was expressed both as g/day (adjusted for total energy) and as percent of total fat intake. We used mixed models to test the association and calculate the correlation between the erythrocyte membrane estimates and PUFA intake using all records of data for each youth. RESULTS: Intakes of total omega-3 fatty acids (beta=0.52, P<0.0001, rho=0.23) and marine PUFAs (beta=1.62, P<0.0001, rho=0.42), as a percent of total fat in the diet, were associated with percent of omega-3 and marine PUFAs in the erythrocyte membrane. Intakes of omega-6 PUFAs (beta=0.04, P=0.418, rho=0.05) and arachidonic acid (beta=0.31, P=0.774, rho=0.01) were not associated. CONCLUSIONS: In these young children, an FFQ using parental report provided estimates of average long-term intakes of marine PUFAs that correlated well with their erythrocyte cell membrane fatty acid status.
@article{
title = {Comparison between omega-3 and omega-6 polyunsaturated fatty acid intakes as assessed by a food frequency questionnaire and erythrocyte membrane fatty acid composition in young children},
type = {article},
year = {2008},
identifiers = {[object Object]},
keywords = {*Diet,Biological Markers/blood,Child,Child, Preschool,Cohort Studies,Colorado,Cross-Sectional Studies,Diet Surveys,Dietary Fats, Unsaturated/*administration & dosage,Erythrocyte Membrane/*chemistry,Fatty Acids, Omega-3/*administration & dosage/anal,Fatty Acids, Omega-6/*administration & dosage/*ana,Female,Humans,Infant,Longitudinal Studies,Male,Questionnaires/*standards,Reproducibility of Results,Seafood,Sensitivity and Specificity},
pages = {733-738},
volume = {62},
websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17440518},
edition = {2007/04/19},
id = {73ca6912-d3a5-3d7e-af03-263b919dd64e},
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language = {eng},
notes = {<m:note>Orton, H D<m:linebreak/>Szabo, N J<m:linebreak/>Clare-Salzler, M<m:linebreak/>Norris, J M<m:linebreak/>DK32493/DK/NIDDK NIH HHS/United States<m:linebreak/>P30 DK 57516/DK/NIDDK NIH HHS/United States<m:linebreak/>P30 DK057516-019004/DK/NIDDK NIH HHS/United States<m:linebreak/>R01 DK049654-06/DK/NIDDK NIH HHS/United States<m:linebreak/>R01-DK49654/DK/NIDDK NIH HHS/United States<m:linebreak/>R37 DK032493-18/DK/NIDDK NIH HHS/United States<m:linebreak/>Research Support, N.I.H., Extramural<m:linebreak/>Validation Studies<m:linebreak/>England<m:linebreak/>European journal of clinical nutrition<m:linebreak/>1602763<m:linebreak/>Eur J Clin Nutr. 2008 Jun;62(6):733-8. Epub 2007 Apr 18.</m:note>},
abstract = {OBJECTIVE: We conducted a dietary validation study in youth aged 1-11 years by comparing dietary intake of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) as assessed by a parent-completed semiquantitative food frequency questionnaire (FFQ) over time to erythrocyte membrane composition of the same fatty acids. DESIGN: The study population included youth aged 1-11 years who were participants in the Diabetes Autoimmunity Study in the Young (DAISY), a longitudinal study in Denver, Colorado that is following a cohort of youth at risk for developing type I diabetes. Four hundred and four children who had erythrocyte membrane fatty acid data matched to an FFQ corresponding to the same time frame for a total of 917 visits (matches) were included. PUFA intake was expressed both as g/day (adjusted for total energy) and as percent of total fat intake. We used mixed models to test the association and calculate the correlation between the erythrocyte membrane estimates and PUFA intake using all records of data for each youth. RESULTS: Intakes of total omega-3 fatty acids (beta=0.52, P<0.0001, rho=0.23) and marine PUFAs (beta=1.62, P<0.0001, rho=0.42), as a percent of total fat in the diet, were associated with percent of omega-3 and marine PUFAs in the erythrocyte membrane. Intakes of omega-6 PUFAs (beta=0.04, P=0.418, rho=0.05) and arachidonic acid (beta=0.31, P=0.774, rho=0.01) were not associated. CONCLUSIONS: In these young children, an FFQ using parental report provided estimates of average long-term intakes of marine PUFAs that correlated well with their erythrocyte cell membrane fatty acid status.},
bibtype = {article},
author = {Orton, H D and Szabo, N J and Clare-Salzler, M and Norris, J M},
journal = {Eur J Clin Nutr},
number = {6}
}Has UK guidance affected general practitioner antibiotic prescribing for otitis media in children?. Thompson, P. L., Gilbert, R. E., Long, P. F., Saxena, S., Sharland, M., & Wong, I. C. K. Journal of Public Health (Oxford, England), 30(4):479--486, December, 2008.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Since 1997, UK guidance has advocated limiting antibiotic prescribing for otitis media. It is not known whether this has influenced general practitioner prescribing practice. Aims and objectives To investigate the trends in diagnoses and antibiotic prescribing for otitis media in children in relation to guidance. METHODS: We used the General Practice Research Database to conduct time-trend analyses of diagnoses and antibiotic prescribing for otitis media in 3 months to 15 years old, between 1990 and 2006. RESULTS: A total of 1 210 237 otitis media episodes were identified in 464 845 children; two-thirds (68%; 818 006) received antibiotics. Twenty-two percent (267 335) were classified as acute, 85% (227 335) of which received antibiotics. Overall, antibiotic prescribing for otitis media declined by 51% between 1995 and 2000. Much of this reduction predated guidance. During this period, prescribing for otitis media coded as acute increased by 22%. Children diagnosed with acute otitis media were more likely to receive antibiotics than otitis media not coded as acute (P \textless 0.05). From 2000 prescribing plateaued, despite publication of further guidance. Otitis media diagnoses consistently paralleled prescribing. CONCLUSIONS: The reduction in antibiotic prescribing for otitis media predated guidance. The simultaneous decrease in prescribing for non-acute otitis media and increase for acute otitis media suggest diagnostic transfer, possibly to justify the decision to treat.
@article{thompson_has_2008,
title = {Has {UK} guidance affected general practitioner antibiotic prescribing for otitis media in children?},
volume = {30},
issn = {1741-3850},
doi = {10.1093/pubmed/fdn072},
abstract = {BACKGROUND: Since 1997, UK guidance has advocated limiting antibiotic prescribing for otitis media. It is not known whether this has influenced general practitioner prescribing practice. Aims and objectives To investigate the trends in diagnoses and antibiotic prescribing for otitis media in children in relation to guidance.
METHODS: We used the General Practice Research Database to conduct time-trend analyses of diagnoses and antibiotic prescribing for otitis media in 3 months to 15 years old, between 1990 and 2006.
RESULTS: A total of 1 210 237 otitis media episodes were identified in 464 845 children; two-thirds (68\%; 818 006) received antibiotics. Twenty-two percent (267 335) were classified as acute, 85\% (227 335) of which received antibiotics. Overall, antibiotic prescribing for otitis media declined by 51\% between 1995 and 2000. Much of this reduction predated guidance. During this period, prescribing for otitis media coded as acute increased by 22\%. Children diagnosed with acute otitis media were more likely to receive antibiotics than otitis media not coded as acute (P {\textless} 0.05). From 2000 prescribing plateaued, despite publication of further guidance. Otitis media diagnoses consistently paralleled prescribing.
CONCLUSIONS: The reduction in antibiotic prescribing for otitis media predated guidance. The simultaneous decrease in prescribing for non-acute otitis media and increase for acute otitis media suggest diagnostic transfer, possibly to justify the decision to treat.},
language = {eng},
number = {4},
journal = {Journal of Public Health (Oxford, England)},
author = {Thompson, P. L. and Gilbert, R. E. and Long, P. F. and Saxena, S. and Sharland, M. and Wong, I. C. K.},
month = dec,
year = {2008},
pmid = {18765405},
keywords = {Adolescent, Amoxicillin, Anti-Bacterial Agents, Child, Child, Preschool, Confidence Intervals, Erythromycin, Family Practice, Female, Great Britain, Guideline Adherence, Humans, Infant, Male, Otitis Media, Physician's Practice Patterns, Practice Guidelines as Topic, databases as topic},
pages = {479--486}
}Assessment of children for acute respiratory infections in hospital outpatients in Tanzania: what drives good practice?. Chandler, C., I., R., Nadjm, B., Boniface, G., Juma, K., Reyburn, H., & Whitty, C., J., M. The American journal of tropical medicine and hygiene, 79(6):925-32, 12, 2008.
Paper abstract bibtex
Paper abstract bibtex Respiratory infections cause significant mortality in developing countries but are frequently undiagnosed. Reasons for this are unclear. We observed 1,081 outpatient consultations with patients less than five years of age in Tanzania. In 554 patients with cough or difficulty breathing, the absolute percentages examined were 5% for respiratory rate counted, 14% chest exposed, and 25% stethoscope used. Decisions to conduct particular examinations did appear to follow clinical logic, with odds ratios of 4.28 for counting respiratory rate (95% confidence interval [CI]=1.75-10.47), 2.57 for exposing the chest (95% CI=1.67-3.95), and 18.91 for using a stethoscope (95% CI=9.52-37.57) in patients with cough or difficulty breathing. Non-clinical variables, including salary level, were also associated with examinations, and history taking was more common among clinicians originating outside the hospital area. Although respiratory examinations are relatively more common in those with cough or difficulty breathing, the absolute rates are low and related to non-clinical and clinical factors.
@article{
id = {2a81e749-ad05-3a4c-a113-bff2d3dc91b1},
title = {Assessment of children for acute respiratory infections in hospital outpatients in Tanzania: what drives good practice?},
type = {article},
year = {2008},
identifiers = {[object Object]},
keywords = {Acute Disease,Child,Female,Hospital,Hospital: standards,Humans,Infant,Male,Odds Ratio,Outpatient Clinics,Preschool,Respiratory Tract Infections,Respiratory Tract Infections: diagnosis,Tanzania},
created = {2010-05-18T05:27:29.000Z},
pages = {925-32},
volume = {79},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/19052307},
month = {12},
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abstract = {Respiratory infections cause significant mortality in developing countries but are frequently undiagnosed. Reasons for this are unclear. We observed 1,081 outpatient consultations with patients less than five years of age in Tanzania. In 554 patients with cough or difficulty breathing, the absolute percentages examined were 5% for respiratory rate counted, 14% chest exposed, and 25% stethoscope used. Decisions to conduct particular examinations did appear to follow clinical logic, with odds ratios of 4.28 for counting respiratory rate (95% confidence interval [CI]=1.75-10.47), 2.57 for exposing the chest (95% CI=1.67-3.95), and 18.91 for using a stethoscope (95% CI=9.52-37.57) in patients with cough or difficulty breathing. Non-clinical variables, including salary level, were also associated with examinations, and history taking was more common among clinicians originating outside the hospital area. Although respiratory examinations are relatively more common in those with cough or difficulty breathing, the absolute rates are low and related to non-clinical and clinical factors.},
bibtype = {article},
author = {Chandler, Clare I R and Nadjm, Behzad and Boniface, Gloria and Juma, Kaseem and Reyburn, Hugh and Whitty, Christopher J M},
journal = {The American journal of tropical medicine and hygiene},
number = {6}
}Congenital fibrosarcoma simulating congenital hemangioma. Requena, C., Miranda, L., Cañete, A., Almenar, S., Nagore, E., Llombart, B., Sanmartín, O., Botella, R., & Guillén, C. Pediatric Dermatology, 25(1):141--144, February, 2008.
doi bibtex
doi bibtex
@article{requena_congenital_2008,
title = {Congenital fibrosarcoma simulating congenital hemangioma},
volume = {25},
issn = {1525-1470},
doi = {10.1111/j.1525-1470.2007.00616.x},
language = {eng},
number = {1},
journal = {Pediatric Dermatology},
author = {Requena, Celia and Miranda, Luis and Cañete, Adela and Almenar, Sergio and Nagore, Eduardo and Llombart, Beatriz and Sanmartín, Onofre and Botella, Rafael and Guillén, Carlos},
month = feb,
year = {2008},
pmid = {18304187},
keywords = {Antineoplastic Combined Chemotherapy Protocols, Arm, Biopsy, Needle, Combined Modality Therapy, Diagnosis, Differential, Female, Fibrosarcoma, Follow-Up Studies, Hemangioma, Humans, Immunohistochemistry, Infant, Newborn, Skin Neoplasms, Surgical Procedures, Operative, Treatment Outcome},
pages = {141--144}
}2007 (2)
Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Chao, H., Wang, S., Lee, W., Wang, Y., & Päpke, O. Environment international, 33(2):239--45, February, 2007.
Paper doi abstract bibtex
Paper doi abstract bibtex In utero exposure to polybrominated diphenyl ethers (PBDEs) reduces the number of ovarian follicles in rat females and causes permanent effects on rat males. Little data have been gathered on the associations between PBDEs exposure and birth outcome and female menstruation characteristics in both epidemiological and animal studies. The aim of this study was to examine how PBDEs in breast milk are associated with infant birth outcome and maternal menstruation characteristics. Study participants were healthy women recruited from central Taiwan between December 2000 and November 2001. Twelve congener levels of PBDEs (BDE-17, 28, 47, 66, 85, 99, 100, 138, 153, 154, 183, 209) in 20 breast milk samples were measured by gas chromatography with high resolution mass spectrometer. The mean level of PBDEs in breast milk was 3.93+/-1.74 ng/g lipid. The estimated PBDE daily intake for a breastfed infant was 20.6 ng/kg b.w./day after delivery. After maternal age, pre-pregnant BMI, and parity were adjusted, increased PBDEs in breast milk was related with decreased birth outcome, particularly for birth weight and length, chest circumference, and Quetelet's index of infants. No significant differences in PBDEs were found between the two groups of menstrual cycle length higher and lower than 30 days after we adjusted for maternal age, pre-pregnant BMI, and parity. In utero exposure to low doses of PBDEs may result in lower birth weight and short or birth length. Our findings are limited based on the low doses of PBDEs and the small sampling size.
@article{chao_levels_2007,
title = {Levels of polybrominated diphenyl ethers ({PBDEs}) in breast milk from central {Taiwan} and their relation to infant birth outcome and maternal menstruation effects.},
volume = {33},
issn = {0160-4120},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17079016},
doi = {10.1016/j.envint.2006.09.013},
abstract = {In utero exposure to polybrominated diphenyl ethers (PBDEs) reduces the number of ovarian follicles in rat females and causes permanent effects on rat males. Little data have been gathered on the associations between PBDEs exposure and birth outcome and female menstruation characteristics in both epidemiological and animal studies. The aim of this study was to examine how PBDEs in breast milk are associated with infant birth outcome and maternal menstruation characteristics. Study participants were healthy women recruited from central Taiwan between December 2000 and November 2001. Twelve congener levels of PBDEs (BDE-17, 28, 47, 66, 85, 99, 100, 138, 153, 154, 183, 209) in 20 breast milk samples were measured by gas chromatography with high resolution mass spectrometer. The mean level of PBDEs in breast milk was 3.93+/-1.74 ng/g lipid. The estimated PBDE daily intake for a breastfed infant was 20.6 ng/kg b.w./day after delivery. After maternal age, pre-pregnant BMI, and parity were adjusted, increased PBDEs in breast milk was related with decreased birth outcome, particularly for birth weight and length, chest circumference, and Quetelet's index of infants. No significant differences in PBDEs were found between the two groups of menstrual cycle length higher and lower than 30 days after we adjusted for maternal age, pre-pregnant BMI, and parity. In utero exposure to low doses of PBDEs may result in lower birth weight and short or birth length. Our findings are limited based on the low doses of PBDEs and the small sampling size.},
number = {2},
journal = {Environment international},
author = {Chao, How-Ran and Wang, Shu-Li and Lee, Wen-Jhy and Wang, Ya-Fen and Päpke, Olaf},
month = feb,
year = {2007},
pmid = {17079016},
keywords = {Cohort Studies, Ethers, Female, Flame retardants, Gas Chromatography-Mass Spectrometry, Human, Human: chemistry, Humans, Infant, Menstruation, Milk, Polybrominated Biphenyls, Polybrominated Biphenyls: analysis, Pregnancy, Pregnancy Outcome, ffr, hum},
pages = {239--45}
}The utility of the general practice research database to examine selected congenital heart defects: a validation study. Wurst, K. E., Ephross, S. A., Loehr, J., Clark, D. W., & Guess, H. A. Pharmacoepidemiology and Drug Safety, 16(8):867--877, August, 2007.
doi abstract bibtex
doi abstract bibtex
OBJECTIVE: The purpose of this research was (1) to validate that ventricular septal defect (VSD), tetralogy of Fallot (TOF), and coarctation of the aorta (COA) can be studied in the UK General practice research database (GPRD) and (2) to understand which of the available GPRD components (computerized medical records, questionnaires, and maternal/infant free text) provide maximal information about these heart defects. METHODS: Using a practitioner questionnaire, the positive predictive value (PPV) of the computerized medical record for VSD, TOF, and COA were determined. Both infant and maternal free text was examined. Concordance between the infant free text information and questionnaires was calculated. The proportion of infant information captured in the maternal free text was determined. RESULTS: A 93% response rate was achieved. Based on questionnaire responses, an overall PPV of 93.5% was achieved (VSD = 95%, TOF = 90%, COA = 100%). Approximately half of the records contained infant free text information including information on the type and size of VSD, echocardiogram findings, and surgery. Concordance between the infant's free text and questionnaire information occurred in most of the cases (92-100%). The proportion of infant information in the maternal free text was low (4-19%). CONCLUSION: The GPRD computerized medical records are sufficient to assess VSD, TOF, and COA. This study confirms that maternal free text provides a low yield of limited information pertaining to the infants' defect, while the infant free text may provide an additional information usually obtainable from practitioner questionnaires. The information provided by an infant free text may limit the need for practitioner questionnaire validation.
@article{wurst_utility_2007,
title = {The utility of the general practice research database to examine selected congenital heart defects: a validation study},
volume = {16},
issn = {1053-8569},
shorttitle = {The utility of the general practice research database to examine selected congenital heart defects},
doi = {10.1002/pds.1431},
abstract = {OBJECTIVE: The purpose of this research was (1) to validate that ventricular septal defect (VSD), tetralogy of Fallot (TOF), and coarctation of the aorta (COA) can be studied in the UK General practice research database (GPRD) and (2) to understand which of the available GPRD components (computerized medical records, questionnaires, and maternal/infant free text) provide maximal information about these heart defects.
METHODS: Using a practitioner questionnaire, the positive predictive value (PPV) of the computerized medical record for VSD, TOF, and COA were determined. Both infant and maternal free text was examined. Concordance between the infant free text information and questionnaires was calculated. The proportion of infant information captured in the maternal free text was determined.
RESULTS: A 93\% response rate was achieved. Based on questionnaire responses, an overall PPV of 93.5\% was achieved (VSD = 95\%, TOF = 90\%, COA = 100\%). Approximately half of the records contained infant free text information including information on the type and size of VSD, echocardiogram findings, and surgery. Concordance between the infant's free text and questionnaire information occurred in most of the cases (92-100\%). The proportion of infant information in the maternal free text was low (4-19\%).
CONCLUSION: The GPRD computerized medical records are sufficient to assess VSD, TOF, and COA. This study confirms that maternal free text provides a low yield of limited information pertaining to the infants' defect, while the infant free text may provide an additional information usually obtainable from practitioner questionnaires. The information provided by an infant free text may limit the need for practitioner questionnaire validation.},
language = {eng},
number = {8},
journal = {Pharmacoepidemiology and Drug Safety},
author = {Wurst, K. E. and Ephross, S. A. and Loehr, J. and Clark, D. W. and Guess, H. A.},
month = aug,
year = {2007},
pmid = {17563909},
keywords = {Aortic Coarctation, Data Collection, Databases, Factual, Epidemiologic Methods, Great Britain, Heart Septal Defects, Ventricular, Humans, Infant, Newborn, Medical Records Systems, Computerized, Physicians, Family, Questionnaires, Reproducibility of Results, Tetralogy of Fallot},
pages = {867--877}
}2006 (4)
Child passenger safety for inner-city Latinos: new approaches from the community. Martin, M., Holden, J., Chen, Z., & Quinlan, K. Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention, 12(2):99-104, 4, 2006.
Website abstract bibtex
Website abstract bibtex Motor vehicle crashes injuries, the leading cause of death for Latino children in the United States, can be reduced by the correct use of child safety seats. This study evaluated the ability of a community health worker education program to improve proper child safety seat usage in urban low income Latino families.
@article{
title = {Child passenger safety for inner-city Latinos: new approaches from the community.},
type = {article},
year = {2006},
identifiers = {[object Object]},
keywords = {Adolescent,Adult,Attitudes,Automobiles,Child,Community Health Services,Community Health Services: organization & administ,Female,Health Education,Health Education: methods,Health Knowledge,Hispanic Americans,Humans,Infant,Infant Equipment,Infant Equipment: utilization,Male,Middle Aged,Newborn,Parents,Practice,Preschool,Program Evaluation,United States,Urban Health Services,Urban Health Services: organization & administrati,Wounds and Injuries,Wounds and Injuries: ethnology,Wounds and Injuries: prevention & control},
pages = {99-104},
volume = {12},
websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2577363&tool=pmcentrez&rendertype=abstract},
month = {4},
id = {87fdea4a-6f0c-3a6b-86a9-61cad4b0a1b7},
created = {2016-09-13T00:48:25.000Z},
accessed = {2016-09-05},
file_attached = {false},
profile_id = {c7856f8a-4963-3e63-90cb-57986d91c9b0},
group_id = {1fd78437-06d9-37cf-b89d-417b03940b66},
last_modified = {2016-09-13T05:55:52.000Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {false},
hidden = {false},
abstract = {Motor vehicle crashes injuries, the leading cause of death for Latino children in the United States, can be reduced by the correct use of child safety seats. This study evaluated the ability of a community health worker education program to improve proper child safety seat usage in urban low income Latino families.},
bibtype = {article},
author = {Martin, M. and Holden, J. and Chen, Z. and Quinlan, K.},
journal = {Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention},
number = {2}
}Car seat safety for high-risk infants. Howard-Salsman, K., D. Neonatal network : NN, 25(2):117-29, 2006.
Website abstract bibtex
Website abstract bibtex Most neonates discharged from the hospital are able to go home in a standard car safety seat. Some infants, though, require special devices to ensure their safe travel. NICU nurses must have the knowledge and skills to comfortably and competently give vital information to parents preparing to take their infant home. This article is intended to increase awareness among NICU nurses of the potential dangers babies face when placed in a car seat. It provides a basic overview of car seat safety for infants being discharged home from an NICU and includes references for those who seek further information on this topic.
@article{
title = {Car seat safety for high-risk infants.},
type = {article},
year = {2006},
identifiers = {[object Object]},
keywords = {Accident Prevention,Body Size,Choice Behavior,Clinical Competence,Equipment Design,Equipment Failure,Guidelines as Topic,Humans,Infant,Infant Equipment,Infant Equipment: adverse effects,Infant Equipment: standards,Infant Equipment: supply & distribution,Information Services,Intensive Care,Internet,Neonatal,Neonatal Nursing,Neonatal Nursing: organization & administration,Newborn,Nurse's Role,Nursing Assessment,Parents,Parents: education,Parents: psychology,Patient Discharge,Posture,Premature,Safety Management,Safety Management: organization & administration},
pages = {117-29},
volume = {25},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/16610484},
id = {e7a39718-3128-3251-9c50-4cbba5e2c22a},
created = {2016-09-13T00:48:28.000Z},
accessed = {2016-09-05},
file_attached = {false},
profile_id = {c7856f8a-4963-3e63-90cb-57986d91c9b0},
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last_modified = {2016-09-13T05:55:55.000Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {false},
hidden = {false},
abstract = {Most neonates discharged from the hospital are able to go home in a standard car safety seat. Some infants, though, require special devices to ensure their safe travel. NICU nurses must have the knowledge and skills to comfortably and competently give vital information to parents preparing to take their infant home. This article is intended to increase awareness among NICU nurses of the potential dangers babies face when placed in a car seat. It provides a basic overview of car seat safety for infants being discharged home from an NICU and includes references for those who seek further information on this topic.},
bibtype = {article},
author = {Howard-Salsman, Kimberly D.},
journal = {Neonatal network : NN},
number = {2}
}Age-related changes in consultations and antibiotic prescribing for acute respiratory infections, 1995-2000. Data from the UK General Practice Research Database. Ashworth, M., Charlton, J., Latinovic, R., & Gulliford, M. Journal of Clinical Pharmacy and Therapeutics, 31(5):461--467, October, 2006.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: International studies using data aggregated for all ages have shown decreasing rates of general practice consultations for acute respiratory infections with fewer antibiotic prescriptions issued per consultation. The occurrence of different respiratory infections varies widely at different ages but we do not know whether prescribing has reduced equally in all age groups. OBJECTIVE: We aimed to determine how reductions in consultation rates and antibiotic prescribing varied with age for different respiratory infections. METHODS: Data were abstracted from the General Practice Research Database for 108 general practices in the UK (mean registered population 642 685). We estimated age-specific changes between 1995 and 2000 in consultation rates, and the proportion of consultations resulting in an antibiotic prescription for 'all respiratory infections' and for 'sore throat', 'ear infection', 'bronchitis' and 'chest infection'. RESULTS: Consultation rates for 'all respiratory infections' declined in all age groups with the greatest decreases in children aged 1-4 years (41%), 5-10 year olds (53%) and 11-16 year olds (54%), whereas at 75-84 years the reduction was 28%. The pattern of greater reductions in children held for each separate condition even though the age of peak incidence varied. The relative reduction in antibiotic prescribing was greatest at 1-4 years (18%), 5-10 years (17%) and 11-16 years (17%), compared with 5% at 75-84 years. Antibiotic prescribing decreased most for sore throat and this was observed at all ages particularly in 5-10 year olds (relative reduction, 32%). CONCLUSIONS: School age children account for the greatest reduction in consultations for acute respiratory infection. School age and preschool children account for the greatest reductions in antibiotic prescribing during the consultation. The rapid changes in consultation rates are unexplained.
@article{ashworth_age-related_2006,
title = {Age-related changes in consultations and antibiotic prescribing for acute respiratory infections, 1995-2000. {Data} from the {UK} {General} {Practice} {Research} {Database}},
volume = {31},
issn = {0269-4727},
doi = {10.1111/j.1365-2710.2006.00765.x},
abstract = {BACKGROUND: International studies using data aggregated for all ages have shown decreasing rates of general practice consultations for acute respiratory infections with fewer antibiotic prescriptions issued per consultation. The occurrence of different respiratory infections varies widely at different ages but we do not know whether prescribing has reduced equally in all age groups.
OBJECTIVE: We aimed to determine how reductions in consultation rates and antibiotic prescribing varied with age for different respiratory infections.
METHODS: Data were abstracted from the General Practice Research Database for 108 general practices in the UK (mean registered population 642 685). We estimated age-specific changes between 1995 and 2000 in consultation rates, and the proportion of consultations resulting in an antibiotic prescription for 'all respiratory infections' and for 'sore throat', 'ear infection', 'bronchitis' and 'chest infection'.
RESULTS: Consultation rates for 'all respiratory infections' declined in all age groups with the greatest decreases in children aged 1-4 years (41\%), 5-10 year olds (53\%) and 11-16 year olds (54\%), whereas at 75-84 years the reduction was 28\%. The pattern of greater reductions in children held for each separate condition even though the age of peak incidence varied. The relative reduction in antibiotic prescribing was greatest at 1-4 years (18\%), 5-10 years (17\%) and 11-16 years (17\%), compared with 5\% at 75-84 years. Antibiotic prescribing decreased most for sore throat and this was observed at all ages particularly in 5-10 year olds (relative reduction, 32\%).
CONCLUSIONS: School age children account for the greatest reduction in consultations for acute respiratory infection. School age and preschool children account for the greatest reductions in antibiotic prescribing during the consultation. The rapid changes in consultation rates are unexplained.},
language = {eng},
number = {5},
journal = {Journal of Clinical Pharmacy and Therapeutics},
author = {Ashworth, M. and Charlton, J. and Latinovic, R. and Gulliford, M.},
month = oct,
year = {2006},
pmid = {16958824},
keywords = {Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Anti-Bacterial Agents, Child, Child, Preschool, Confidence Intervals, Databases, Factual, Family Practice, Great Britain, Humans, Infant, Middle Aged, Physician's Practice Patterns, Respiratory Tract Infections},
pages = {461--467}
}A long-term population-based clinical and morbidity review of Prader-Willi syndrome in Western Australia. Thomson, A., K., Glasson, E., J., & Bittles, A., H. J Intellect Disabil Res, 50(Pt 1):69-78, 2006.
Website abstract bibtex
Website abstract bibtex BACKGROUND: An investigation of the clinical morbidity and genetic profiles of individuals with Prader-Willi syndrome (PWS) in Western Australia (WA) was undertaken as part of a wider study into the effects of intellectual disability (ID) on the life course of individuals. METHODS: All persons with a diagnosis of PWS were identified from the records of the Disability Services Commission of WA (DSC). The DSC client files formed the main data source, and were supplemented by information from other state health data sets. The analysis was retrospective and quantitative in nature. RESULTS: A total of 56 individuals were identified, 10 of whom exhibited normal methylation patterns and so were analysed separately (PWS-like). The ages of the PWS group ranged from 0.9 to 48.3 years, with six persons deceased. Most people with PWS (76%) had mild or moderate ID, and 70% lived in their family home. The birth prevalence of the disorder was 1 in 29 500 births. Respiratory disorders, dentistry and gastrointestinal disorders were common reasons for hospital admission, with epilepsy or convulsions also reported at moderate frequency. The PWS-like group shared many clinical features in common with PWS patients, the principal exceptions being hypotonia and feeding difficulties in infancy. CONCLUSIONS: The estimated birth prevalence of PWS was lower than expected; however, the case ascertainment method may have excluded some individuals. Older people with PWS were generally living in sheltered accommodation. As the cohort ages, demand for places in similar accommodation will increase, adding to the existing burden on service providers. Substantial future increases in the use of medical services and hospital-based care also are predicted with the onset of age-associated disorders.
@article{
title = {A long-term population-based clinical and morbidity review of Prader-Willi syndrome in Western Australia},
type = {article},
year = {2006},
identifiers = {[object Object]},
keywords = {Adolescent,Adult,Age of Onset,Child,Child, Preschool,Cohort Studies,Comorbidity,Female,Humans,Infant,Male,Middle Aged,Prader-Willi Syndrome/*epidemiology/genetics/*psyc,Prevalence,Residence Characteristics,Retrospective Studies,Time Factors,Western Australia/epidemiology},
pages = {69-78},
volume = {50},
websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16316432},
edition = {2005/12/01},
id = {6304b879-7510-31b5-b1d5-0e08d20fda12},
created = {2017-06-19T13:42:45.337Z},
file_attached = {false},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:42:45.433Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
source_type = {Journal Article},
language = {eng},
notes = {<m:note>Thomson, A K<m:linebreak/>Glasson, E J<m:linebreak/>Bittles, A H<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>England<m:linebreak/>Journal of intellectual disability research : JIDR<m:linebreak/>Jir770<m:linebreak/>J Intellect Disabil Res. 2006 Jan;50(Pt 1):69-78.</m:note>},
abstract = {BACKGROUND: An investigation of the clinical morbidity and genetic profiles of individuals with Prader-Willi syndrome (PWS) in Western Australia (WA) was undertaken as part of a wider study into the effects of intellectual disability (ID) on the life course of individuals. METHODS: All persons with a diagnosis of PWS were identified from the records of the Disability Services Commission of WA (DSC). The DSC client files formed the main data source, and were supplemented by information from other state health data sets. The analysis was retrospective and quantitative in nature. RESULTS: A total of 56 individuals were identified, 10 of whom exhibited normal methylation patterns and so were analysed separately (PWS-like). The ages of the PWS group ranged from 0.9 to 48.3 years, with six persons deceased. Most people with PWS (76%) had mild or moderate ID, and 70% lived in their family home. The birth prevalence of the disorder was 1 in 29 500 births. Respiratory disorders, dentistry and gastrointestinal disorders were common reasons for hospital admission, with epilepsy or convulsions also reported at moderate frequency. The PWS-like group shared many clinical features in common with PWS patients, the principal exceptions being hypotonia and feeding difficulties in infancy. CONCLUSIONS: The estimated birth prevalence of PWS was lower than expected; however, the case ascertainment method may have excluded some individuals. Older people with PWS were generally living in sheltered accommodation. As the cohort ages, demand for places in similar accommodation will increase, adding to the existing burden on service providers. Substantial future increases in the use of medical services and hospital-based care also are predicted with the onset of age-associated disorders.},
bibtype = {article},
author = {Thomson, A K and Glasson, E J and Bittles, A H},
journal = {J Intellect Disabil Res},
number = {Pt 1}
}2005 (3)
Utility of routinely acquired primary care data for paediatric disease epidemiology and pharmacoepidemiology. Helms, P. J., Ekins Daukes, S., Taylor, M. W., Simpson, C. R., & McLay, J. S. British Journal of Clinical Pharmacology, 59(6):684--690, June, 2005.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: The majority of medicines prescribed for children are prescribed in primary care for common acute and chronic conditions. This is in contrast to prescribing in secondary care where the population of children admitted is small but where a large number of different medicines are prescribed to treat more serious and less common conditions. METHODS: Data on prescribing was extracted from the General Practice Administration System for Scotland (GPASS) for the year November 1999 to October 2000 and prescribing patterns for children aged 0-16 years expressed as percentages. A comparison of age specific consultations for asthma, as an example of a common paediatric condition, was also made between two separate general practice data sets, the General Practice Research Database (GRPD) and the continuous morbidity recording (CMR) subset of GPASS. RESULTS: Of 214 medicines investigated for unlicensed and off-label prescribing no unlicensed prescribing was identified. Off-label prescribing due to age was most common among younger and older children. The most common reasons for off-label prescriptions were, in order of frequency, lower than recommended dose, higher than recommended dose, below the recommended age, and unlicensed formulation. Age and gender specific consultations for asthma were similar in the two representative databases, GPRD and CMR, both showing disappearance of the male predominance in the teenage years. CONCLUSIONS: Large primary care data sets available within a unified health care system such as the UK National Health Service (NHS) are likely to be broadly compatible and produce similar results. The prescribing of off-label medicines to children is common in primary care, most commonly due to prescribing out with the recommended dosage regimen.
@article{helms_utility_2005,
title = {Utility of routinely acquired primary care data for paediatric disease epidemiology and pharmacoepidemiology},
volume = {59},
issn = {0306-5251},
doi = {10.1111/j.1365-2125.2005.02404.x},
abstract = {BACKGROUND: The majority of medicines prescribed for children are prescribed in primary care for common acute and chronic conditions. This is in contrast to prescribing in secondary care where the population of children admitted is small but where a large number of different medicines are prescribed to treat more serious and less common conditions.
METHODS: Data on prescribing was extracted from the General Practice Administration System for Scotland (GPASS) for the year November 1999 to October 2000 and prescribing patterns for children aged 0-16 years expressed as percentages. A comparison of age specific consultations for asthma, as an example of a common paediatric condition, was also made between two separate general practice data sets, the General Practice Research Database (GRPD) and the continuous morbidity recording (CMR) subset of GPASS.
RESULTS: Of 214 medicines investigated for unlicensed and off-label prescribing no unlicensed prescribing was identified. Off-label prescribing due to age was most common among younger and older children. The most common reasons for off-label prescriptions were, in order of frequency, lower than recommended dose, higher than recommended dose, below the recommended age, and unlicensed formulation. Age and gender specific consultations for asthma were similar in the two representative databases, GPRD and CMR, both showing disappearance of the male predominance in the teenage years.
CONCLUSIONS: Large primary care data sets available within a unified health care system such as the UK National Health Service (NHS) are likely to be broadly compatible and produce similar results. The prescribing of off-label medicines to children is common in primary care, most commonly due to prescribing out with the recommended dosage regimen.},
language = {eng},
number = {6},
journal = {British Journal of Clinical Pharmacology},
author = {Helms, Peter J. and Ekins Daukes, Suzie and Taylor, Michael W. and Simpson, Colin R. and McLay, James S.},
month = jun,
year = {2005},
pmid = {15948933},
pmcid = {PMC1884863},
keywords = {Adolescent, Age Distribution, Asthma, Child, Child, Preschool, Databases, Factual, Drug Approval, Drug Prescriptions, Female, Humans, Infant, Infant, Newborn, Male, Medical Records Systems, Computerized, Pediatrics, Primary Health Care, Reproducibility of Results, Scotland, State Medicine, pharmacoepidemiology},
pages = {684--690}
}Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians. Roddier, K., Thomas, T., Marleau, G., Gagnon, A., M., Dicaire, M., J., St-Denis, A., Gosselin, I., Sarrazin, A., M., Larbrisseau, A., Lambert, M., Vanasse, M., Gaudet, D., Rouleau, G., A., & Brais, B. Neurology, 64(10):1762-7, 5, 2005.
Website abstract bibtex
Website abstract bibtex Hereditary sensory and autonomic neuropathy type 2 (HSAN2; MIM 201300) is a rare recessive neuropathy typically diagnosed in the first decade. The 1973 study of a French Canadian family led to the definition of HSAN2.
@article{
title = {Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians.},
type = {article},
year = {2005},
identifiers = {[object Object]},
keywords = {Adult,Aged,Base Sequence,Base Sequence: genetics,Child,Child, Preschool,Chromosome Mapping,Chromosomes, Human, Pair 12,Chromosomes, Human, Pair 12: genetics,Cohort Studies,DNA Mutational Analysis,Female,Genetic Predisposition to Disease,Genetic Predisposition to Disease: genetics,Genetic Testing,Genotype,Hereditary Sensory and Autonomic Neuropathies,Hereditary Sensory and Autonomic Neuropathies: epi,Hereditary Sensory and Autonomic Neuropathies: gen,Humans,Infant,Male,Middle Aged,Mutation,Mutation: genetics,Nerve Tissue Proteins,Nerve Tissue Proteins: genetics,Pedigree,Peripheral Nerves,Peripheral Nerves: pathology,Peripheral Nerves: physiopathology,Phenotype,Prevalence,Quebec,Quebec: epidemiology},
pages = {1762-7},
volume = {64},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/15911806},
month = {5},
day = {24},
id = {71758a4d-1534-3114-8245-28d8a8dcfda2},
created = {2017-06-19T13:46:38.335Z},
accessed = {2011-06-02},
file_attached = {false},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:46:38.523Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
abstract = {Hereditary sensory and autonomic neuropathy type 2 (HSAN2; MIM 201300) is a rare recessive neuropathy typically diagnosed in the first decade. The 1973 study of a French Canadian family led to the definition of HSAN2.},
bibtype = {article},
author = {Roddier, K and Thomas, T and Marleau, G and Gagnon, A M and Dicaire, M J and St-Denis, A and Gosselin, I and Sarrazin, A M and Larbrisseau, A and Lambert, M and Vanasse, M and Gaudet, D and Rouleau, G A and Brais, B},
journal = {Neurology},
number = {10}
}Antibiotic prescribing in general practice and hospital admissions for peritonsillar abscess, mastoiditis, and rheumatic fever in children: time trend analysis. Sharland, M., Kendall, H., Yeates, D., Randall, A., Hughes, G., Glasziou, P., & Mant, D. BMJ (Clinical research ed.), 331(7512):328--329, August, 2005.
doi bibtex
doi bibtex
@article{sharland_antibiotic_2005,
title = {Antibiotic prescribing in general practice and hospital admissions for peritonsillar abscess, mastoiditis, and rheumatic fever in children: time trend analysis},
volume = {331},
issn = {1756-1833},
shorttitle = {Antibiotic prescribing in general practice and hospital admissions for peritonsillar abscess, mastoiditis, and rheumatic fever in children},
doi = {10.1136/bmj.38503.706887.AE1},
language = {eng},
number = {7512},
journal = {BMJ (Clinical research ed.)},
author = {Sharland, M. and Kendall, H. and Yeates, D. and Randall, A. and Hughes, G. and Glasziou, P. and Mant, D.},
month = aug,
year = {2005},
pmid = {15967760},
pmcid = {PMC1183132},
keywords = {Adolescent, Anti-Bacterial Agents, Child, Child, Preschool, Drug Utilization, England, Family Practice, Hospitalization, Humans, Infant, Infant, Newborn, Mastoiditis, Peritonsillar Abscess, Physician's Practice Patterns, Referral and Consultation, Respiratory Tract Infections, Rheumatic Fever},
pages = {328--329}
}2004 (1)
Autism and DPT vaccination in the United Kingdom. Jick, H. & Kaye, J. A. The New England Journal of Medicine, 350(26):2722--2723, June, 2004.
doi bibtex
doi bibtex
@article{jick_autism_2004,
title = {Autism and {DPT} vaccination in the {United} {Kingdom}},
volume = {350},
issn = {1533-4406},
doi = {10.1056/NEJM200406243502623},
language = {eng},
number = {26},
journal = {The New England Journal of Medicine},
author = {Jick, Hershel and Kaye, James A.},
month = jun,
year = {2004},
pmid = {15215496},
keywords = {Autistic Disorder, Case-Control Studies, Child, Preschool, Diphtheria-Tetanus-Pertussis Vaccine, Great Britain, Humans, Infant, Male, Thimerosal},
pages = {2722--2723}
}2003 (4)
Medical outcome of pregnancy in women with psychotic disorders and their infants in the first year after birth. Howard, L. M., Goss, C., Leese, M., & Thornicroft, G. The British Journal of Psychiatry: The Journal of Mental Science, 182:63--67, January, 2003.
abstract bibtex
abstract bibtex
BACKGROUND: There has been little research into the health of infants of women with psychotic disorders. AIMS: To investigate the antenatal care of mothers with a history of psychotic disorders, obstetric outcomes and the subsequent health of their babies. METHOD: A matched, controlled cohort study was carried out using the General Practice Research Database. Women with a history of a psychotic disorder, who gave birth in 1996-1998, were compared with women matched for age and general practice (199 cases and 787 controls) and their infants. RESULTS: Cases had a higher proportion of stillbirths (OR=4.03, 95% CI 1.14-4.25, P=0.03) and neonatal deaths (P\textless0.001). There was no difference in gestational age at antenatal booking. Mothers with psychotic disorders were less likely than controls to attend for infant immunisations 90-270 days after birth (RR=0.94, 95% CI 0.88-0.99, P=0.03). There was no significant difference in the rates of accidents and hospital contacts for infants. CONCLUSIONS: There is an increased risk of stillbirth and neonatal death in women with a history of psychotic disorder, and it is therefore important for health care professionals to focus on optimal obstetric care. The physical health of babies who live with mothers with psychotic disorders is not significantly different from that of matched baby controls.
@article{howard_medical_2003,
title = {Medical outcome of pregnancy in women with psychotic disorders and their infants in the first year after birth},
volume = {182},
issn = {0007-1250},
abstract = {BACKGROUND: There has been little research into the health of infants of women with psychotic disorders.
AIMS: To investigate the antenatal care of mothers with a history of psychotic disorders, obstetric outcomes and the subsequent health of their babies.
METHOD: A matched, controlled cohort study was carried out using the General Practice Research Database. Women with a history of a psychotic disorder, who gave birth in 1996-1998, were compared with women matched for age and general practice (199 cases and 787 controls) and their infants.
RESULTS: Cases had a higher proportion of stillbirths (OR=4.03, 95\% CI 1.14-4.25, P=0.03) and neonatal deaths (P{\textless}0.001). There was no difference in gestational age at antenatal booking. Mothers with psychotic disorders were less likely than controls to attend for infant immunisations 90-270 days after birth (RR=0.94, 95\% CI 0.88-0.99, P=0.03). There was no significant difference in the rates of accidents and hospital contacts for infants.
CONCLUSIONS: There is an increased risk of stillbirth and neonatal death in women with a history of psychotic disorder, and it is therefore important for health care professionals to focus on optimal obstetric care. The physical health of babies who live with mothers with psychotic disorders is not significantly different from that of matched baby controls.},
language = {eng},
journal = {The British Journal of Psychiatry: The Journal of Mental Science},
author = {Howard, Louise M. and Goss, Claudia and Leese, Morven and Thornicroft, Graham},
month = jan,
year = {2003},
pmid = {12509320},
keywords = {Accidents, Adolescent, Adult, Alcohol Drinking, Case-Control Studies, Female, Fetal Death, Gestational Age, Hospitalization, Humans, Immunization, Infant, Newborn, Patient Acceptance of Health Care, Pregnancy Complications, Pregnancy Outcome, Prenatal Care, Psychotic Disorders, Smoking, pregnancy},
pages = {63--67}
}Population screening in the age of genomic medicine. Khoury, M., J., McCabe, L., L., & McCabe, E., R. N Engl J Med, 348(1):50-58, 2003.
Paper bibtex
Paper bibtex @article{
title = {Population screening in the age of genomic medicine},
type = {article},
year = {2003},
keywords = {*Genetic Screening/ethics/legislation & jurisprude,*Neonatal Screening/ethics/legislation & jurisprud,Adult,Child,Cystic Fibrosis/diagnosis/genetics,Factor V/genetics,Female,Genomics,Hemochromatosis/diagnosis/genetics,Heterozygote,Human,Infant, Newborn,Point Mutation,Tay-Sachs Disease/diagnosis/genetics},
pages = {50-58},
volume = {348},
id = {4a011104-dc6c-3027-acd0-5bcf83e843dd},
created = {2017-06-19T13:44:20.292Z},
file_attached = {true},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:44:20.533Z},
tags = {03/09/17},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
source_type = {Journal Article},
notes = {<m:note>Journal Article<m:linebreak/>Review<m:linebreak/>Review, Tutorial</m:note>},
bibtype = {article},
author = {Khoury, M J and McCabe, L L and McCabe, E R},
journal = {N Engl J Med},
number = {1}
}MMR vaccine and idiopathic thrombocytopaenic purpura. Black, C., Kaye, J. A., & Jick, H. British Journal of Clinical Pharmacology, 55(1):107--111, January, 2003.
abstract bibtex
abstract bibtex
AIMS: To estimate the relationship between idiopathic thrombocytopaenic purpura (ITP) and the measles, mumps and rubella (MMR) vaccination in children; calculating the relative risk estimate for ITP with in 6 weeks after MMR vaccination and the attributable risk of ITP within 6 weeks after MMR vaccination. METHODS: Using the General Practice Research Database we identified children with a first-time diagnosis of ITP from a base population of children aged less than 6 years between January 1988 and December 1999. After describing the characteristics of all the children identified with ITP, we focused on cases aged 13-24 months to perform a population-based, case-control analysis to estimate the relative risk of developing ITP within 6 weeks after MMR vaccination. We also calculated the risk of ITP attributable to the MMR vaccination. RESULTS: Sixty-three children with a first time diagnosis of ITP were identified; 23 cases were between 13 and 24 months old. The relative risk estimate for ITP within 6 weeks after MMR vaccination, compared to the combined group of unvaccinated children and children vaccinated with MMR more than 26 weeks previously was 6.3 (95% CI 1.3-30.1). The attributable risk of developing ITP within 6 weeks after MMR vaccination was estimated to be 1 in 25,000 vaccinations (95% confidence interval 21,300, 89,400). CONCLUSION: This study confirms the increased risk of ITP within 6 weeks after MMR vaccination. However, the attributable risk of ITP within 6 weeks after MMR vaccination is low.
@article{black_mmr_2003,
title = {{MMR} vaccine and idiopathic thrombocytopaenic purpura},
volume = {55},
issn = {0306-5251},
abstract = {AIMS: To estimate the relationship between idiopathic thrombocytopaenic purpura (ITP) and the measles, mumps and rubella (MMR) vaccination in children; calculating the relative risk estimate for ITP with in 6 weeks after MMR vaccination and the attributable risk of ITP within 6 weeks after MMR vaccination.
METHODS: Using the General Practice Research Database we identified children with a first-time diagnosis of ITP from a base population of children aged less than 6 years between January 1988 and December 1999. After describing the characteristics of all the children identified with ITP, we focused on cases aged 13-24 months to perform a population-based, case-control analysis to estimate the relative risk of developing ITP within 6 weeks after MMR vaccination. We also calculated the risk of ITP attributable to the MMR vaccination.
RESULTS: Sixty-three children with a first time diagnosis of ITP were identified; 23 cases were between 13 and 24 months old. The relative risk estimate for ITP within 6 weeks after MMR vaccination, compared to the combined group of unvaccinated children and children vaccinated with MMR more than 26 weeks previously was 6.3 (95\% CI 1.3-30.1). The attributable risk of developing ITP within 6 weeks after MMR vaccination was estimated to be 1 in 25,000 vaccinations (95\% confidence interval 21,300, 89,400).
CONCLUSION: This study confirms the increased risk of ITP within 6 weeks after MMR vaccination. However, the attributable risk of ITP within 6 weeks after MMR vaccination is low.},
language = {eng},
number = {1},
journal = {British Journal of Clinical Pharmacology},
author = {Black, Corri and Kaye, James A. and Jick, Hershel},
month = jan,
year = {2003},
pmid = {12534647},
pmcid = {PMC1884189},
keywords = {Case-Control Studies, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Measles-Mumps-Rubella Vaccine, Purpura, Thrombocytopenic, Idiopathic, Risk Factors},
pages = {107--111}
}Hereditary motor and sensory neuropathy with agenesis of the corpus callosum. Dupre, N., Howard, H., C., Mathieu, J., Karpati, G., Vanasse, M., Bouchard, J., P., Carpenter, S., & Rouleau, G., A. Ann Neurol, 54(1):9-18, 2003.
Paper abstract bibtex
Paper abstract bibtex Hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (OMIM 218000) is an autosomal recessive disease of early onset characterized by a delay in developmental milestones, a severe sensory-motor polyneuropathy with areflexia, a variable degree of agenesis of the corpus callosum, amyotrophy, hypotonia, and cognitive impairment. Although this disorder has rarely been reported worldwide, it has a high prevalence in the Saguenay-Lac-St-Jean region of the province of Quebec (Canada) predominantly because of a founder effect. The gene defect responsible for this disorder recently has been identified, and it is a protein-truncating mutation in the SLC12A6 gene, which codes for a cotransporter protein known as KCC3. Herein, we provide the first extensive review of this disorder, covering epidemiological, clinical, and molecular genetic studies.
@article{
title = {Hereditary motor and sensory neuropathy with agenesis of the corpus callosum},
type = {article},
year = {2003},
identifiers = {[object Object]},
keywords = {Adolescent,Adult,Atrophy/pathology,Brachial Plexus Neuritis/epidemiology,Brain/pathology,Child,Child, Preschool,Cognition Disorders/epidemiology,Comorbidity,Corpus Callosum/*abnormalities,Electromyography,Exons/genetics,Female,Gene Deletion,Genotype,Hereditary Motor and Sensory,Homozygote,Human,Infant,Infant, Newborn,Magnetic Resonance Imaging,Male,Median Nerve/physiopathology,Muscle Hypotonia/epidemiology,Neural Conduction/physiology,Neuropathies/epidemiology/*genetics/physiopatholog,Point Mutation/genetics,Quebec/epidemiology,Reflex, Abnormal/physiology,Support, Non-U.S. Gov't,Symporters/genetics},
pages = {9-18},
volume = {54},
id = {99285bba-7525-3fd4-81d8-6fb91fc4d581},
created = {2017-06-19T13:45:18.932Z},
file_attached = {true},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:45:19.076Z},
tags = {04/09/01},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
source_type = {Journal Article},
notes = {<m:note>Journal Article<m:linebreak/>Review<m:linebreak/>Review of Reported Cases</m:note>},
abstract = {Hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (OMIM 218000) is an autosomal recessive disease of early onset characterized by a delay in developmental milestones, a severe sensory-motor polyneuropathy with areflexia, a variable degree of agenesis of the corpus callosum, amyotrophy, hypotonia, and cognitive impairment. Although this disorder has rarely been reported worldwide, it has a high prevalence in the Saguenay-Lac-St-Jean region of the province of Quebec (Canada) predominantly because of a founder effect. The gene defect responsible for this disorder recently has been identified, and it is a protein-truncating mutation in the SLC12A6 gene, which codes for a cotransporter protein known as KCC3. Herein, we provide the first extensive review of this disorder, covering epidemiological, clinical, and molecular genetic studies.},
bibtype = {article},
author = {Dupre, N and Howard, H C and Mathieu, J and Karpati, G and Vanasse, M and Bouchard, J P and Carpenter, S and Rouleau, G A},
journal = {Ann Neurol},
number = {1}
}2002 (2)
What is the Birth Defect Risk Associated With Consanguineous Marriages ?. Zlotogora, J. American journal of medical genetics, 109(1):70-71, 2002.
Paper bibtex
Paper bibtex @article{
title = {What is the Birth Defect Risk Associated With Consanguineous Marriages ?},
type = {article},
year = {2002},
identifiers = {[object Object]},
keywords = {*Consanguinity,Abnormalities/*genetics,Child,Female,Human,Infant,Male,Preschool,Risk Factors},
pages = {70-71},
volume = {109},
id = {f8021355-3e47-3c4b-b4f4-b8bb58d6fc41},
created = {2017-06-19T13:42:00.462Z},
file_attached = {true},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:42:00.784Z},
tags = {04/11/22},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
source_type = {Journal Article},
notes = {<m:note> <m:bold>From Duplicate 1 ( </m:bold> <m:bold> </m:bold><m:bold><m:italic>What is the birth defect risk associated with consanguineous marriages?</m:italic></m:bold><m:bold> </m:bold> <m:bold> - Zlotogora, J )<m:linebreak/> </m:bold> <m:linebreak/>Case Reports<m:linebreak/>Letter<m:linebreak/> <m:linebreak/> </m:note>},
bibtype = {article},
author = {Zlotogora, Joël},
journal = {American journal of medical genetics},
number = {1}
}Efficacy and tolerance of gastrostomy feeding in pediatric forms of neuromuscular diseases. Seguy D, Michaud L, Guimber D, Cuisset JM, Devos P, Turck D, & Gottrand F J. Parenter. Enter. Nutr., 26:298-304, 2002.
Paper bibtex
Paper bibtex @article{seguy_d_EFFICACY_2002,
title = {Efficacy and tolerance of gastrostomy feeding in pediatric forms of neuromuscular diseases},
volume = {26},
issn = {0148-6071},
url = {http://www.ncbi.nlm.nih.gov/pubmed/12216710},
Language = {English},
Journal = {J. Parenter. Enter. Nutr.},
author = {{Seguy D} and {Michaud L} and {Guimber D} and {Cuisset JM} and {Devos P} and {Turck D} and {Gottrand F}},
year = {2002},
keywords = {Adolescent, Adult, Child, Child, Preschool, Enteral Nutrition*, Female, Follow-Up Studies, Gastroesophageal Reflux/complications, Gastrostomy*, Humans, Infant, Infant, Newborn, Male, Neuromuscular Diseases/complications, Neuromuscular Diseases/therapy*, Nutritional Status, Treatment Outcome, Weight Gain},
pages = {298-304}
}2001 (5)
Endemic stability--a veterinary idea applied to human public health. Coleman, P. G., Perry, B. D., & Woolhouse, M. E. Lancet (London, England), 357(9264):1284--1286, April, 2001.
abstract bibtex
abstract bibtex
Endemic stability is an epidemiological state of a population, in which clinical disease is scarce despite high level of infection. The notion was developed to describe patterns of tick-borne disease in cattle. However, we propose a general model of endemic stability that is applicable to a broader range of diseases that are important in public health, including malaria, rubella, and mumps. We postulate that endemic stability requires only that (1) the probability, or severity, of clinical disease after infection increases with age, and (2) after one infection, the probability that subsequent infections result in disease is reduced. We present these criteria in simple mathematical terms. Our hypothesis predicts that partial disease control activities might, under certain circumstances, lead to an increase in disease incidence. We discuss the implications for public health interventions.
@article{coleman_endemic_2001,
title = {Endemic stability--a veterinary idea applied to human public health.},
volume = {357},
issn = {0140-6736 0140-6736},
abstract = {Endemic stability is an epidemiological state of a population, in which clinical disease is scarce despite high level of infection. The notion was developed to describe patterns of tick-borne disease in cattle. However, we propose a general model of endemic stability that is applicable to a broader range of diseases that are important in public health, including malaria, rubella, and mumps. We postulate that endemic stability requires only that (1) the probability, or severity, of clinical disease after infection increases with age, and (2) after one infection, the probability that subsequent infections result in disease is reduced. We present these criteria in simple mathematical terms. Our hypothesis predicts that partial disease control activities might, under certain circumstances, lead to an increase in disease incidence. We discuss the implications for public health interventions.},
language = {eng},
number = {9264},
journal = {Lancet (London, England)},
author = {Coleman, P. G. and Perry, B. D. and Woolhouse, M. E.},
month = apr,
year = {2001},
pmid = {11418173},
keywords = {*Endemic Diseases, *Epidemiologic Methods, *Models, Theoretical, *Public Health, Age Distribution, Animals, Child, Preschool, Communicable Diseases/*epidemiology/etiology, Humans, Incidence, Infant, Infant, Newborn},
pages = {1284--1286}
}Lipoblastoma and lipoblastomatosis: a report of two cases and review of the literature. Harrer, J., Hammon, G., Wagner, T., & Bolkenius, M. European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie, 11(5):342--349, October, 2001.
doi abstract bibtex
doi abstract bibtex
Lipoblastoma and lipoblastomatosis are rare benign neoplasms of foetal white fat tissue that occur almost exclusively in infants and children. Two cases are reported and a review of the literature is given. An almost one-year-old girl and a full-term male infant were brought to our hospital with a solid mass in the right thigh. Nine months after total excision of the lipoblastoma, the little girl developed tumour recurrence, with unexpected histopathological maturation. In the case of the little boy, lipoblastomatosis with infiltration of the surrounding muscles, together with involvement of the sciatic and posterior femoral cutaneous nerves was found. Histologically, the tumour showed an unusual inflammatory reaction. The diagnosis of this tumour was made by the pathologist, but the histopathological picture bears a striking similarity to myxoid liposarcoma, and may be indistinguishable. Recent studies describe rearrangements of chromosome 8 q11-q13 region as a new discriminative marker that distinguishes lipoblastoma and lipoblastomatosis from myxoid liposarcoma.
@article{harrer_lipoblastoma_2001,
title = {Lipoblastoma and lipoblastomatosis: a report of two cases and review of the literature},
volume = {11},
issn = {0939-7248},
shorttitle = {Lipoblastoma and lipoblastomatosis},
doi = {10.1055/s-2001-18544},
abstract = {Lipoblastoma and lipoblastomatosis are rare benign neoplasms of foetal white fat tissue that occur almost exclusively in infants and children. Two cases are reported and a review of the literature is given. An almost one-year-old girl and a full-term male infant were brought to our hospital with a solid mass in the right thigh. Nine months after total excision of the lipoblastoma, the little girl developed tumour recurrence, with unexpected histopathological maturation. In the case of the little boy, lipoblastomatosis with infiltration of the surrounding muscles, together with involvement of the sciatic and posterior femoral cutaneous nerves was found. Histologically, the tumour showed an unusual inflammatory reaction. The diagnosis of this tumour was made by the pathologist, but the histopathological picture bears a striking similarity to myxoid liposarcoma, and may be indistinguishable. Recent studies describe rearrangements of chromosome 8 q11-q13 region as a new discriminative marker that distinguishes lipoblastoma and lipoblastomatosis from myxoid liposarcoma.},
language = {eng},
number = {5},
journal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie},
author = {Harrer, J. and Hammon, G. and Wagner, T. and Bolkenius, M.},
month = oct,
year = {2001},
pmid = {11719876},
keywords = {Biopsy, Buttocks, Diagnosis, Differential, Female, Humans, Infant, Infant, Newborn, Lipoma, Liposarcoma, Myxoid, Magnetic Resonance Imaging, Male, Recurrence, Retrospective Studies, Thigh, ultrasonography},
pages = {342--349}
}Molecular genetic alterations on chromosomes 11 and 22 in ependymomas. Lamszus, K., Lachenmayer, L., Heinemann, U., Kluwe, L., Finckh, U., Höppner, W., Stavrou, D., Fillbrandt, R., & Westphal, M. International journal of cancer, 91(6):803-8, 3, 2001.
Paper abstract bibtex
Paper abstract bibtex Ependymomas arise from the ependymal cells at different locations throughout the brain and spinal cord. These tumors have a broad age distribution with a range from less than 1 year to more than 80 years. In some intramedullary spinal ependymomas, mutations in the neurofibromatosis 2 (NF2) gene and loss of heterozygosity (LOH) on chromosome arm 22q have been described. Cytogenetic studies have also identified alterations involving chromosome arm 11q, including rearrangements at 11q13, in ependymomas. We analyzed 21 intramedullary spinal, 14 ventricular, 11 filum terminale and 6 intracerebral ependymomas for mutations in the MEN1 gene, which is located at 11q13, and mutations in the NF2 gene, which is located at 22q12, as well as for LOH on 11q and 22q. NF2 mutations were found in 6 tumors, all of which were intramedullary spinal and all of which displayed LOH 22q. Allelic loss on 22q was found in 20 cases and was significantly more frequent in intramedullary spinal ependymomas than in tumors in other locations. LOH 11q was found in 7 patients and exhibited a highly significant inverse association with LOH 22q (p<0.001). A hemizygous MEN1 mutation was identified in 3 tumors, all of which were recurrences from the same patient. Interestingly, the initial tumor corresponded to WHO grade II and displayed LOH 11q but not yet a MEN1 mutation. In 2 subsequent recurrences, the tumor had progressed to anaplastic ependymoma (WHO grade III) and exhibited a nonsense mutation in exon 10 of MEN1 (W471X) in conjunction with LOH 11q. This suggests that loss of wild-type MEN1 may be involved in the malignant progression of a subset of ependymomas. To conclude, our findings provide evidence for different genetic pathways involved in ependymoma formation and progression, which may allow to define genetically and clinically distinct tumor entities.
@article{
title = {Molecular genetic alterations on chromosomes 11 and 22 in ependymomas},
type = {article},
year = {2001},
identifiers = {[object Object]},
keywords = {Adolescent,Adult,Aged,Alleles,Base Sequence,Brain Neoplasms,Brain Neoplasms: genetics,Child,Chromosome Deletion,Chromosomes,DNA,DNA Primers,DNA Primers: chemistry,Ependymoma,Ependymoma: genetics,Ependymoma: pathology,Female,Genes,Human,Humans,Infant,Loss of Heterozygosity,Male,Microsatellite Repeats,Middle Aged,Mutation,Neoplasm Proteins,Neoplasm Proteins: genetics,Neurofibromatosis 2,Neurofibromatosis 2: genetics,Newborn,Pair 11,Pair 11: genetics,Pair 22,Pair 22: genetics,Polymerase Chain Reaction,Preschool,Proto-Oncogene Proteins,Sequence Analysis,Spinal Cord Neoplasms,Spinal Cord Neoplasms: genetics},
pages = {803-8},
volume = {91},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/11275983},
month = {3},
day = {15},
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abstract = {Ependymomas arise from the ependymal cells at different locations throughout the brain and spinal cord. These tumors have a broad age distribution with a range from less than 1 year to more than 80 years. In some intramedullary spinal ependymomas, mutations in the neurofibromatosis 2 (NF2) gene and loss of heterozygosity (LOH) on chromosome arm 22q have been described. Cytogenetic studies have also identified alterations involving chromosome arm 11q, including rearrangements at 11q13, in ependymomas. We analyzed 21 intramedullary spinal, 14 ventricular, 11 filum terminale and 6 intracerebral ependymomas for mutations in the MEN1 gene, which is located at 11q13, and mutations in the NF2 gene, which is located at 22q12, as well as for LOH on 11q and 22q. NF2 mutations were found in 6 tumors, all of which were intramedullary spinal and all of which displayed LOH 22q. Allelic loss on 22q was found in 20 cases and was significantly more frequent in intramedullary spinal ependymomas than in tumors in other locations. LOH 11q was found in 7 patients and exhibited a highly significant inverse association with LOH 22q (p<0.001). A hemizygous MEN1 mutation was identified in 3 tumors, all of which were recurrences from the same patient. Interestingly, the initial tumor corresponded to WHO grade II and displayed LOH 11q but not yet a MEN1 mutation. In 2 subsequent recurrences, the tumor had progressed to anaplastic ependymoma (WHO grade III) and exhibited a nonsense mutation in exon 10 of MEN1 (W471X) in conjunction with LOH 11q. This suggests that loss of wild-type MEN1 may be involved in the malignant progression of a subset of ependymomas. To conclude, our findings provide evidence for different genetic pathways involved in ependymoma formation and progression, which may allow to define genetically and clinically distinct tumor entities.},
bibtype = {article},
author = {Lamszus, K and Lachenmayer, L and Heinemann, U and Kluwe, L and Finckh, U and Höppner, W and Stavrou, D and Fillbrandt, R and Westphal, M},
journal = {International journal of cancer},
number = {6}
}Patterns of prescribing of nutritional supplements in the United Kingdom. Gale, C. R., Edington, J., Coles, S. J., & Martyn, C. N. Clinical Nutrition (Edinburgh, Scotland), 20(4):333--337, August, 2001.
doi abstract bibtex
doi abstract bibtex
BACKGROUND AND AIMS: A large number of prescriptions are issued for nutritional supplements under British National Formulary classifications 9.4.1 (foods for special diets) and 9.4.2 (enteral feeds), but little is known about the characteristics of the patients who receive them. We used the General Practice Research Database to examine patterns of prescribing of these supplements. METHODS: We selected patients who had been prescribed supplements under classifications 9.4.1 and 9.4.2 during 1996-1997. Descriptive statistics were used to examine how prescribing varied. RESULTS: 28644 patients received prescriptions during 1996-1997. Among the 27413 (96%) patients prescribed supplements for oral use, 14750 received supplements for enteral nutrition alone, 8122 received supplements for special diets alone and 4541 had both types of supplement. 51% of patients receiving supplements for special diets were \textless18 years. The commonest diagnoses among such children were milk intolerance (24%) and malnutrition (17%). 94% of patients receiving supplements for enteral nutrition were adult, 52% of whom had cancer or cardiovascular disease. Only 4% of patients had weight and height recorded prior to first prescription. CONCLUSIONS: The GPRD provides valuable information on the characteristics of patients prescribed nutritional supplements. But because only limited data are available on their nutritional status prior to supplementation, it is hard to assess whether general practitioners are prescribing these supplements appropriately.
@article{gale_patterns_2001,
title = {Patterns of prescribing of nutritional supplements in the {United} {Kingdom}},
volume = {20},
issn = {0261-5614},
doi = {10.1054/clnu.2001.0396},
abstract = {BACKGROUND AND AIMS: A large number of prescriptions are issued for nutritional supplements under British National Formulary classifications 9.4.1 (foods for special diets) and 9.4.2 (enteral feeds), but little is known about the characteristics of the patients who receive them. We used the General Practice Research Database to examine patterns of prescribing of these supplements.
METHODS: We selected patients who had been prescribed supplements under classifications 9.4.1 and 9.4.2 during 1996-1997. Descriptive statistics were used to examine how prescribing varied.
RESULTS: 28644 patients received prescriptions during 1996-1997. Among the 27413 (96\%) patients prescribed supplements for oral use, 14750 received supplements for enteral nutrition alone, 8122 received supplements for special diets alone and 4541 had both types of supplement. 51\% of patients receiving supplements for special diets were {\textless}18 years. The commonest diagnoses among such children were milk intolerance (24\%) and malnutrition (17\%). 94\% of patients receiving supplements for enteral nutrition were adult, 52\% of whom had cancer or cardiovascular disease. Only 4\% of patients had weight and height recorded prior to first prescription.
CONCLUSIONS: The GPRD provides valuable information on the characteristics of patients prescribed nutritional supplements. But because only limited data are available on their nutritional status prior to supplementation, it is hard to assess whether general practitioners are prescribing these supplements appropriately.},
language = {eng},
number = {4},
journal = {Clinical Nutrition (Edinburgh, Scotland)},
author = {Gale, C. R. and Edington, J. and Coles, S. J. and Martyn, C. N.},
month = aug,
year = {2001},
pmid = {11478831},
keywords = {Adolescent, Adult, Age Distribution, Aged, Child, Child, Preschool, Databases, Factual, Dietary Supplements, Drug Prescriptions, Enteral Nutrition, Family Practice, Female, Food, Formulated, Gastrointestinal Diseases, Great Britain, Humans, Infant, Infant, Newborn, Male, Middle Aged, Nutrition Disorders, Nutritional Status, Physician's Practice Patterns},
pages = {333--337}
}Trends in the prevalence and management of atrial fibrillation in general practice in England and Wales, 1994-1998: analysis of data from the general practice research database. Majeed, A., Moser, K., & Carroll, K. Heart (British Cardiac Society), 86(3):284--288, September, 2001.
abstract bibtex
abstract bibtex
OBJECTIVE: To determine the prevalence of atrial fibrillation in England and Wales, and examine trends in its treatment with warfarin and aspirin between 1994 and 1998. DESIGN: Analysis of data from the general practice research database. SETTING: England and Wales. PATIENTS: 1.4 million patients registered with 211 general practices. MAIN OUTCOME MEASURES: Age and sex specific prevalence rates of atrial fibrillation; percentage of patients with atrial fibrillation treated with oral anticoagulants or aspirin. RESULTS: The prevalence of atrial fibrillation in 1998 was 12.1/1000 in men and 12.7/1000 in women. Prevalence increased from less than 1/1000 in under 35 year olds to over 100/1000 in those aged 85 years and over. There was a 22% increase in the age standardised prevalence of atrial fibrillation in men and a 14% increase in women between 1994 and 1998. The percentage of patients prescribed oral anticoagulants increased from 20% to 34% in men and from 17% to 25% in women. The percentage of men with atrial fibrillation prescribed aspirin increased from 26% to 36%, and the percentage of women increased from 24% to 36%. Applying the age and sex specific prevalence and treatment rates to the population gives an estimate of around 650 000 cases of atrial fibrillation in England and Wales. The greatest number of cases occurs in the 75-84 year old age group. CONCLUSIONS: The number of patients in the community with identified atrial fibrillation is increasing. There has also been a pronounced increase in the percentage of patients with atrial fibrillation prescribed oral anticoagulants or aspirin.
@article{majeed_trends_2001,
title = {Trends in the prevalence and management of atrial fibrillation in general practice in {England} and {Wales}, 1994-1998: analysis of data from the general practice research database},
volume = {86},
issn = {1468-201X},
shorttitle = {Trends in the prevalence and management of atrial fibrillation in general practice in {England} and {Wales}, 1994-1998},
abstract = {OBJECTIVE: To determine the prevalence of atrial fibrillation in England and Wales, and examine trends in its treatment with warfarin and aspirin between 1994 and 1998.
DESIGN: Analysis of data from the general practice research database.
SETTING: England and Wales.
PATIENTS: 1.4 million patients registered with 211 general practices.
MAIN OUTCOME MEASURES: Age and sex specific prevalence rates of atrial fibrillation; percentage of patients with atrial fibrillation treated with oral anticoagulants or aspirin.
RESULTS: The prevalence of atrial fibrillation in 1998 was 12.1/1000 in men and 12.7/1000 in women. Prevalence increased from less than 1/1000 in under 35 year olds to over 100/1000 in those aged 85 years and over. There was a 22\% increase in the age standardised prevalence of atrial fibrillation in men and a 14\% increase in women between 1994 and 1998. The percentage of patients prescribed oral anticoagulants increased from 20\% to 34\% in men and from 17\% to 25\% in women. The percentage of men with atrial fibrillation prescribed aspirin increased from 26\% to 36\%, and the percentage of women increased from 24\% to 36\%. Applying the age and sex specific prevalence and treatment rates to the population gives an estimate of around 650 000 cases of atrial fibrillation in England and Wales. The greatest number of cases occurs in the 75-84 year old age group.
CONCLUSIONS: The number of patients in the community with identified atrial fibrillation is increasing. There has also been a pronounced increase in the percentage of patients with atrial fibrillation prescribed oral anticoagulants or aspirin.},
language = {eng},
number = {3},
journal = {Heart (British Cardiac Society)},
author = {Majeed, A. and Moser, K. and Carroll, K.},
month = sep,
year = {2001},
pmid = {11514479},
pmcid = {PMC1729916},
keywords = {Administration, Oral, Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Anticoagulants, Aspirin, Atrial Fibrillation, Child, Child, Preschool, England, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Platelet Aggregation Inhibitors, Prevalence, Sex Distribution, Wales, Warfarin},
pages = {284--288}
}2000 (6)
Multivariate frailty model with a major gene: application to genealogical data. Begun, A., Desjardins, B., Iachine, I., & Yashin, A. Stud Health Technol Inform, 77:412-416, 2000.
Website abstract bibtex
Website abstract bibtex Multivariate survival models are shown to be appropriate for the analysis of the genetic and the environmental nature of a human life-span. Models which involve continuously distributed individual frailty, play an important role in the genetic analysis of an individual's susceptibility to disease and death. These models, however, are not appropriate for the detection of the effects of separate genes on survival. For this purpose we developed a 'major gene' frailty model of multivariate survival and applied it to simulated and real pedigree data. The analysis shows that this model can be used for the detection of the presence of major genes in the population and for the evaluation of the effects of such genes on survival.
@article{
title = {Multivariate frailty model with a major gene: application to genealogical data},
type = {article},
year = {2000},
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keywords = {*Genetic Predisposition to Disease,*Models, Genetic,Adolescent,Adult,Alleles,Child,Child, Preschool,Female,Genotype,Humans,Infant,Infant, Newborn,Longevity/*genetics,Male,Mathematical Computing,Multivariate Analysis,Quebec,Risk,Software,Survival Analysis},
pages = {412-416},
volume = {77},
websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11187585},
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notes = {<m:note>0926-9630<m:linebreak/>Journal Article</m:note>},
abstract = {Multivariate survival models are shown to be appropriate for the analysis of the genetic and the environmental nature of a human life-span. Models which involve continuously distributed individual frailty, play an important role in the genetic analysis of an individual's susceptibility to disease and death. These models, however, are not appropriate for the detection of the effects of separate genes on survival. For this purpose we developed a 'major gene' frailty model of multivariate survival and applied it to simulated and real pedigree data. The analysis shows that this model can be used for the detection of the presence of major genes in the population and for the evaluation of the effects of such genes on survival.},
bibtype = {article},
author = {Begun, A and Desjardins, B and Iachine, I and Yashin, A},
journal = {Stud Health Technol Inform}
}Combined treatment of fourth ventricle ependymomas: report of 26 cases. Spagnoli, D., Tomei, G., Ceccarelli, G., Grimoldi, N., Lanterna, A., Bello, L., Sinisi, M., M., De Santis, A., & Villani, R., M. Surgical Neurology, 54(1):19-26; discussion 26, 7, 2000.
Paper abstract bibtex
Paper abstract bibtex This study investigated the relevance of prognostic factors and the impact of histological features in posterior fossa ependymoma.
@article{
title = {Combined treatment of fourth ventricle ependymomas: report of 26 cases},
type = {article},
year = {2000},
identifiers = {[object Object]},
keywords = {Adolescent,Adult,Antineoplastic Combined Chemotherapy Protocols,Antineoplastic Combined Chemotherapy Protocols: th,Brain Neoplasms,Brain Neoplasms: mortality,Brain Neoplasms: pathology,Brain Neoplasms: therapy,Child,Combined Modality Therapy,Cranial Fossa,Ependymoma,Ependymoma: mortality,Ependymoma: pathology,Ependymoma: therapy,Female,Follow-Up Studies,Fourth Ventricle,Fourth Ventricle: radiation effects,Fourth Ventricle: surgery,Humans,Infant,Male,Middle Aged,Posterior,Posterior: radiation effects,Posterior: surgery,Preschool,Radiotherapy Dosage,Retrospective Studies,Survival Rate,Treatment Outcome},
pages = {19-26; discussion 26},
volume = {54},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/11024503},
month = {7},
id = {7cd94e64-54ff-3d5c-8cac-190b02d239a4},
created = {2013-08-05T21:04:27.000Z},
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last_modified = {2014-11-22T16:36:55.000Z},
read = {false},
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abstract = {This study investigated the relevance of prognostic factors and the impact of histological features in posterior fossa ependymoma.},
bibtype = {article},
author = {Spagnoli, D and Tomei, G and Ceccarelli, G and Grimoldi, N and Lanterna, A and Bello, L and Sinisi, M M and De Santis, A and Villani, R M},
journal = {Surgical Neurology},
number = {1}
}Familial cancer risks to offspring from mothers with 2 primary breast cancers: leads to cancer syndromes. Hemminki, K., Vaittinen, P., & Easton, D. Int J Cancer, 88(1):87-91., 2000.
abstract bibtex
abstract bibtex
The nationwide Swedish Family-Cancer Database was used to analyse the risk of cancer among the offspring of bilateral breast cancer patients. We studied 4,734 such mothers who had 9,391 offspring, of whom 328 presented with a primary cancer in the years 1958-1996. Standardised incidence ratios (SIRs) were increased for breast [SIR 3.05, 95% confidence interval (CI) 2.57-3.59], ovarian (SIR 1.84, 95% CI 1.03-3.05) and anogenital (SIR 1.75, 95% CI 1.11-2.63) cancers and childhood sarcomas (SIR 9.39, 95% CI 1.93-29.13). Additionally, squamous-cell skin cancer was increased among sons and all childhood cancers among daughters. When analysed by histological type, adenocarcinomas of the breast and ovary, all squamous-cell carcinomas and tumours at glandular epithelium (seminomas and intestinal carcinoids) were increased. Mothers with bilateral breast cancer had an excess of 2 or more children with cancer. The increased risk of ovarian cancer is consistent with germline mutations in the BRCA1 and BRCA2 genes, while the risk of soft tissue and bone sarcomas may reflect the association of these tumours with Li-Fraumeni syndrome. The increases in squamous-cell carcinomas at many sites may reflect a new susceptibility syndrome.
@article{
title = {Familial cancer risks to offspring from mothers with 2 primary breast cancers: leads to cancer syndromes},
type = {article},
year = {2000},
identifiers = {[object Object]},
keywords = {Adolescence,Adult,Breast Neoplasms/epidemiology/*genetics,Child,Child, Preschool,Databases, Factual,Family Health,Female,Human,Incidence,Infant,Infant, Newborn,Male,Middle Age,Mothers,Neoplasms, Second Primary/epidemiology/*genetics,Neoplasms/epidemiology/*genetics,Risk Factors,Socioeconomic Factors,Support, Non-U.S. Gov't,Sweden/epidemiology},
pages = {87-91.},
volume = {88},
id = {588e6ac8-7072-3509-b985-6895b25455d2},
created = {2017-06-19T13:44:44.036Z},
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read = {false},
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confirmed = {true},
hidden = {false},
source_type = {Journal Article},
notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>},
abstract = {The nationwide Swedish Family-Cancer Database was used to analyse the risk of cancer among the offspring of bilateral breast cancer patients. We studied 4,734 such mothers who had 9,391 offspring, of whom 328 presented with a primary cancer in the years 1958-1996. Standardised incidence ratios (SIRs) were increased for breast [SIR 3.05, 95% confidence interval (CI) 2.57-3.59], ovarian (SIR 1.84, 95% CI 1.03-3.05) and anogenital (SIR 1.75, 95% CI 1.11-2.63) cancers and childhood sarcomas (SIR 9.39, 95% CI 1.93-29.13). Additionally, squamous-cell skin cancer was increased among sons and all childhood cancers among daughters. When analysed by histological type, adenocarcinomas of the breast and ovary, all squamous-cell carcinomas and tumours at glandular epithelium (seminomas and intestinal carcinoids) were increased. Mothers with bilateral breast cancer had an excess of 2 or more children with cancer. The increased risk of ovarian cancer is consistent with germline mutations in the BRCA1 and BRCA2 genes, while the risk of soft tissue and bone sarcomas may reflect the association of these tumours with Li-Fraumeni syndrome. The increases in squamous-cell carcinomas at many sites may reflect a new susceptibility syndrome.},
bibtype = {article},
author = {Hemminki, K and Vaittinen, P and Easton, D},
journal = {Int J Cancer},
number = {1}
}Natural selection and sex differences in morbidity and mortality in early life. Wells, J., C. Journal of theoretical biology, 202(1):65-76, 1, 2000.
Paper Website abstract bibtex
Paper Website abstract bibtex Both morbidity and mortality are consistently reported to be higher in males than in females in early life, but no explanation for these findings has been offered. This paper argues that the sex difference in early vulnerability can be attributed to the natural selection of optimal maternal strategies for maximizing lifetime reproductive success, as modelled previously by Trivers and Willard. These authors theorized that males and females offer different returns on parental investment depending on the state of the environment. Natural selection has therefore favoured maternal ability to manipulate offspring sex in response to environmental conditions in early life, as shown in variation in the sex ratio at birth. This argument can be extended to the whole period of parental investment until weaning. Male vulnerability in response to environmental stress in early life is predicted to have been favoured by natural selection. This vulnerability is most evident in the harsh conditions resulting from pre-term birth, but can also be seen in term infants, and manifests as greater morbidity and mortality persisting into early childhood. Malnutrition, interacting with infection after birth, is suggested as the fundamental trigger mechanism. The model suggests that whatever improvements are made in medical care, any environmental stress will always affect males more severely than females in early life.
@article{
title = {Natural selection and sex differences in morbidity and mortality in early life.},
type = {article},
year = {2000},
identifiers = {[object Object]},
keywords = {Bacterial Infections,Bacterial Infections: mortality,Environment,Female,Humans,Infant Mortality,Infant, Newborn,Infant, Premature,Male,Morbidity,Nutrition Disorders,Nutrition Disorders: mortality,Selection, Genetic,Sex Ratio},
pages = {65-76},
volume = {202},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/10623500},
month = {1},
day = {7},
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abstract = {Both morbidity and mortality are consistently reported to be higher in males than in females in early life, but no explanation for these findings has been offered. This paper argues that the sex difference in early vulnerability can be attributed to the natural selection of optimal maternal strategies for maximizing lifetime reproductive success, as modelled previously by Trivers and Willard. These authors theorized that males and females offer different returns on parental investment depending on the state of the environment. Natural selection has therefore favoured maternal ability to manipulate offspring sex in response to environmental conditions in early life, as shown in variation in the sex ratio at birth. This argument can be extended to the whole period of parental investment until weaning. Male vulnerability in response to environmental stress in early life is predicted to have been favoured by natural selection. This vulnerability is most evident in the harsh conditions resulting from pre-term birth, but can also be seen in term infants, and manifests as greater morbidity and mortality persisting into early childhood. Malnutrition, interacting with infection after birth, is suggested as the fundamental trigger mechanism. The model suggests that whatever improvements are made in medical care, any environmental stress will always affect males more severely than females in early life.},
bibtype = {article},
author = {Wells, J C},
journal = {Journal of theoretical biology},
number = {1}
}Data mining applied to linkage disequilibrium mapping. Toivonen, H., T., Onkamo, P., Vasko, K., Ollikainen, V., Sevon, P., Mannila, H., Herr, M., & Kere, J. Am J Hum Genet, 67(1):133-45., 2000.
abstract bibtex
abstract bibtex
We introduce a new method for linkage disequilibrium mapping: haplotype pattern mining (HPM). The method, inspired by data mining methods, is based on discovery of recurrent patterns. We define a class of useful haplotype patterns in genetic case-control data and use the algorithm for finding disease-associated haplotypes. The haplotypes are ordered by their strength of association with the phenotype, and all haplotypes exceeding a given threshold level are used for prediction of disease susceptibility-gene location. The method is model-free, in the sense that it does not require (and is unable to utilize) any assumptions about the inheritance model of the disease. The statistical model is nonparametric. The haplotypes are allowed to contain gaps, which improves the method's robustness to mutations and to missing and erroneous data. Experimental studies with simulated microsatellite and SNP data show that the method has good localization power in data sets with large degrees of phenocopies and with lots of missing and erroneous data. The power of HPM is roughly identical for marker maps at a density of 3 single-nucleotide polymorphisms/cM or 1 microsatellite/cM. The capacity to handle high proportions of phenocopies makes the method promising for complex disease mapping. An example of correct disease susceptibility-gene localization with HPM is given with real marker data from families from the United Kingdom affected by type 1 diabetes. The method is extendable to include environmental covariates or phenotype measurements or to find several genes simultaneously.
@article{
title = {Data mining applied to linkage disequilibrium mapping},
type = {article},
year = {2000},
identifiers = {[object Object]},
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pages = {133-45.},
volume = {67},
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source_type = {Journal Article},
notes = {<m:note>eng<m:linebreak/>Journal Article</m:note>},
abstract = {We introduce a new method for linkage disequilibrium mapping: haplotype pattern mining (HPM). The method, inspired by data mining methods, is based on discovery of recurrent patterns. We define a class of useful haplotype patterns in genetic case-control data and use the algorithm for finding disease-associated haplotypes. The haplotypes are ordered by their strength of association with the phenotype, and all haplotypes exceeding a given threshold level are used for prediction of disease susceptibility-gene location. The method is model-free, in the sense that it does not require (and is unable to utilize) any assumptions about the inheritance model of the disease. The statistical model is nonparametric. The haplotypes are allowed to contain gaps, which improves the method's robustness to mutations and to missing and erroneous data. Experimental studies with simulated microsatellite and SNP data show that the method has good localization power in data sets with large degrees of phenocopies and with lots of missing and erroneous data. The power of HPM is roughly identical for marker maps at a density of 3 single-nucleotide polymorphisms/cM or 1 microsatellite/cM. The capacity to handle high proportions of phenocopies makes the method promising for complex disease mapping. An example of correct disease susceptibility-gene localization with HPM is given with real marker data from families from the United Kingdom affected by type 1 diabetes. The method is extendable to include environmental covariates or phenotype measurements or to find several genes simultaneously.},
bibtype = {article},
author = {Toivonen, H T and Onkamo, P and Vasko, K and Ollikainen, V and Sevon, P and Mannila, H and Herr, M and Kere, J},
journal = {Am J Hum Genet},
number = {1}
}Experience with gastro-intestinal duplications in childhood. Schalamon, J., Schleef, J., & Höllwarth, M. E. Langenbeck's Archives of Surgery, 385(6):402--405, October, 2000.
abstract bibtex
abstract bibtex
BACKGROUND: Intestinal duplications are rare congenital malformations. The different locations and sizes of these duplications require a specific diagnostic and surgical approach. This study reviews our paediatric patients with intestinal duplications in order to analyse the influence of prenatal sonography and laparoscopy on the clinical course. PATIENTS AND METHODS: Thirteen duplications of the alimentary tract in 12 patients have been treated over a 10-year period from 1989 to 1999. Six of our patients were diagnosed prenatally by ultrasound and were free of symptoms until surgery, except for one patient who had meconium-ileus owing to cystic fibrosis. In another five patients, the diagnosis was made on the basis of symptoms with signs of obstruction. In one child, the duplication was found incidentally during an operation for an anorectal malformation. The location of the 13 duplications was the stomach in three cases, the duodenum in one case, the jejunum in two cases, the ileum in six cases and the rectum in one case. Laparotomy was performed in ten patients. Two cases were treated by laparoscopic-assisted resection. CONCLUSION: Early diagnosis and treatment of uncomplicated intestinal duplications by means of prenatal sonographic screening and laparoscopic-assisted resection, respectively, are desirable in this congenital malformation. Resection of the duplication with or without minimal resection of the adjacent normal intestine should be mandatory.
@article{schalamon_experience_2000,
title = {Experience with gastro-intestinal duplications in childhood},
volume = {385},
issn = {1435-2443},
abstract = {BACKGROUND: Intestinal duplications are rare congenital malformations. The different locations and sizes of these duplications require a specific diagnostic and surgical approach. This study reviews our paediatric patients with intestinal duplications in order to analyse the influence of prenatal sonography and laparoscopy on the clinical course.
PATIENTS AND METHODS: Thirteen duplications of the alimentary tract in 12 patients have been treated over a 10-year period from 1989 to 1999. Six of our patients were diagnosed prenatally by ultrasound and were free of symptoms until surgery, except for one patient who had meconium-ileus owing to cystic fibrosis. In another five patients, the diagnosis was made on the basis of symptoms with signs of obstruction. In one child, the duplication was found incidentally during an operation for an anorectal malformation. The location of the 13 duplications was the stomach in three cases, the duodenum in one case, the jejunum in two cases, the ileum in six cases and the rectum in one case. Laparotomy was performed in ten patients. Two cases were treated by laparoscopic-assisted resection.
CONCLUSION: Early diagnosis and treatment of uncomplicated intestinal duplications by means of prenatal sonographic screening and laparoscopic-assisted resection, respectively, are desirable in this congenital malformation. Resection of the duplication with or without minimal resection of the adjacent normal intestine should be mandatory.},
language = {eng},
number = {6},
journal = {Langenbeck's Archives of Surgery},
author = {Schalamon, J. and Schleef, J. and Höllwarth, M. E.},
month = oct,
year = {2000},
pmid = {11127525},
keywords = {Adolescent, Child, Child, Preschool, Duodenum, Female, Humans, Ileum, Infant, Infant, Newborn, Intestine, Small, Jejunum, Male, Pregnancy, Rectum, Retrospective Studies, Stomach, Ultrasonography, Prenatal},
pages = {402--405}
}1999 (1)
Soft-tissue malignancies in infancy. McCarville, M. B., Kaste, S. C., & Pappo, A. S. American Journal of Roentgenology, 173(4):973--977, 1999.
Paper doi bibtex
Paper doi bibtex @article{mccarville_soft-tissue_1999,
title = {Soft-tissue malignancies in infancy},
volume = {173},
issn = {0361-803X},
url = {http://www.ajronline.org/doi/pdf/10.2214/ajr.173.4.10511160},
doi = {10.2214/ajr.173.4.10511160},
language = {eng},
number = {4},
urldate = {2016-06-22TZ},
journal = {American Journal of Roentgenology},
author = {McCarville, M. B. and Kaste, S. C. and Pappo, A. S.},
year = {1999},
pmid = {10511160},
keywords = {Diagnostic Imaging, Female, Fibrosarcoma, Hemangiopericytoma, Humans, Infant, Infant, Newborn, Male, Nerve Sheath Neoplasms, Rhabdomyosarcoma, Soft Tissue Neoplasms},
pages = {973--977}
}1998 (1)
The value of sonography, CT and air enema for detection of complicated Meckel diverticulum in children with nonspecific clinical presentation. Daneman, A., Lobo, E., Alton, D. J., & Shuckett, B. Pediatric Radiology, 28(12):928--932, December, 1998.
doi abstract bibtex
doi abstract bibtex
BACKGROUND: Complicated Meckel diverticulum (MD) in children does not always present with painless rectal bleeding and its presentation can then produce a difficult diagnostic dilemma. In this clinical setting, sonography (US), CT or even air enema may be the first modality chosen to evaluate these children rather than the radionuclide Meckel scan (RNMS). PURPOSE: To assess the value of US, CT and air enema for detection of complicated MD. MATERIALS AND METHODS: Review of clinical, imaging, surgical and pathological findings in 64 children (55 males, 9 females) aged 4 days -14 years (mean = 3.7 years) with MD seen during an 8-year period, 1990-1997. RESULTS: (a) In 33 patients with rectal bleeding, MD was detected on RNMS in 32. Ten of these 32 had other imaging studies, all of which were negative. (b) The other 31 patients, with varied clinical presentations, did not undergo RNMS. In these 31 and the 1 with a negative RNMS, 14 (44 %) had imaging features highly suggestive for the diagnosis of MD on US in all 14, on CT in 1, and on air enema in 3. The radiological spectrum of the inflamed, hemorrhagic MD is illustrated. CONCLUSION: The inflamed, hemorrhagic and the inverted, intussuscepted MD have a spectrum of features recognizable on US, CT and air enema. Some of these appearances are specific, others are not. Knowledge of and recognition of these features will facilitate detection of complicated MD in larger numbers of children presenting with symptoms other than the classic history of painless rectal bleeding and also in those with normal RNMS.
@article{daneman_value_1998,
title = {The value of sonography, {CT} and air enema for detection of complicated {Meckel} diverticulum in children with nonspecific clinical presentation},
volume = {28},
issn = {0301-0449},
doi = {10.1007/s002470050502},
abstract = {BACKGROUND: Complicated Meckel diverticulum (MD) in children does not always present with painless rectal bleeding and its presentation can then produce a difficult diagnostic dilemma. In this clinical setting, sonography (US), CT or even air enema may be the first modality chosen to evaluate these children rather than the radionuclide Meckel scan (RNMS).
PURPOSE: To assess the value of US, CT and air enema for detection of complicated MD.
MATERIALS AND METHODS: Review of clinical, imaging, surgical and pathological findings in 64 children (55 males, 9 females) aged 4 days -14 years (mean = 3.7 years) with MD seen during an 8-year period, 1990-1997.
RESULTS: (a) In 33 patients with rectal bleeding, MD was detected on RNMS in 32. Ten of these 32 had other imaging studies, all of which were negative. (b) The other 31 patients, with varied clinical presentations, did not undergo RNMS. In these 31 and the 1 with a negative RNMS, 14 (44 \%) had imaging features highly suggestive for the diagnosis of MD on US in all 14, on CT in 1, and on air enema in 3. The radiological spectrum of the inflamed, hemorrhagic MD is illustrated.
CONCLUSION: The inflamed, hemorrhagic and the inverted, intussuscepted MD have a spectrum of features recognizable on US, CT and air enema. Some of these appearances are specific, others are not. Knowledge of and recognition of these features will facilitate detection of complicated MD in larger numbers of children presenting with symptoms other than the classic history of painless rectal bleeding and also in those with normal RNMS.},
language = {eng},
number = {12},
journal = {Pediatric Radiology},
author = {Daneman, A. and Lobo, E. and Alton, D. J. and Shuckett, B.},
month = dec,
year = {1998},
pmid = {9880634},
keywords = {Adolescent, Child, Child, Preschool, Enema, Female, Humans, Infant, Infant, Newborn, Male, Meckel Diverticulum, Pneumoradiography, Retrospective Studies, Tomography, X-Ray Computed, ultrasonography},
pages = {928--932}
}1997 (1)
Postoperative radiotherapy of spinal and intracranial ependymomas: analysis of prognostic factors. Stüben, G., Stuschke, M., Kroll, M., Havers, W., & Sack, H. Radiotherapy and Oncology, 45(1):3-10, 10, 1997.
Paper abstract bibtex
Paper abstract bibtex Postoperative radiation therapy adds significantly to disease control and survival of patients with ependymoma. However, much controversy exists about the radiation treatment policy. We report the long-term results of a cohort of 56 patients with primary intracranial and spinal ependymomas. Special effort has been taken to define prognostic indicators as a basis for future treatment strategies.
@article{
title = {Postoperative radiotherapy of spinal and intracranial ependymomas: analysis of prognostic factors},
type = {article},
year = {1997},
identifiers = {[object Object]},
keywords = {Adjuvant,Adolescent,Adult,Aged,Child,Disease-Free Survival,Ependymoma,Ependymoma: mortality,Ependymoma: radiotherapy,Ependymoma: surgery,Female,Follow-Up Studies,Humans,Infant,Infratentorial Neoplasms,Infratentorial Neoplasms: mortality,Infratentorial Neoplasms: radiotherapy,Infratentorial Neoplasms: surgery,Male,Middle Aged,Multivariate Analysis,Preschool,Prognosis,Radiotherapy,Spinal Cord Neoplasms,Spinal Cord Neoplasms: mortality,Spinal Cord Neoplasms: radiotherapy,Spinal Cord Neoplasms: surgery,Supratentorial Neoplasms,Supratentorial Neoplasms: mortality,Supratentorial Neoplasms: radiotherapy,Supratentorial Neoplasms: surgery,Survival Rate,Treatment Outcome},
pages = {3-10},
volume = {45},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/9364625},
month = {10},
id = {87860b46-5742-39ca-a2b8-956b96b23280},
created = {2013-08-05T21:04:27.000Z},
file_attached = {true},
profile_id = {8c4ca2d5-86de-3b5d-86be-8408415f34e0},
group_id = {a484ae4c-fcac-3c7e-9ac3-3fad0df719a2},
last_modified = {2014-12-29T19:36:50.000Z},
read = {true},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
abstract = {Postoperative radiation therapy adds significantly to disease control and survival of patients with ependymoma. However, much controversy exists about the radiation treatment policy. We report the long-term results of a cohort of 56 patients with primary intracranial and spinal ependymomas. Special effort has been taken to define prognostic indicators as a basis for future treatment strategies.},
bibtype = {article},
author = {Stüben, G and Stuschke, M and Kroll, M and Havers, W and Sack, H},
journal = {Radiotherapy and Oncology},
number = {1}
}1995 (2)
Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. Boon, L. M., Fishman, S. J., Lund, D. P., & Mulliken, J. B. Journal of Pediatric Surgery, 30(9):1378--1381, September, 1995.
abstract bibtex
abstract bibtex
The authors report on two infants who had large congenital fibrosarcomas that initially were believed to be hemangiomas. Although hemangioma and congenital fibrosarcoma can have a similar presentation, their treatment is dissimilar. The authors review the anatomic findings, hematologic differences, and radiological clues that can help to differentiate congenital fibrosarcoma from congenital hemangioma.
@article{boon_congenital_1995,
title = {Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases},
volume = {30},
issn = {0022-3468},
shorttitle = {Congenital fibrosarcoma masquerading as congenital hemangioma},
abstract = {The authors report on two infants who had large congenital fibrosarcomas that initially were believed to be hemangiomas. Although hemangioma and congenital fibrosarcoma can have a similar presentation, their treatment is dissimilar. The authors review the anatomic findings, hematologic differences, and radiological clues that can help to differentiate congenital fibrosarcoma from congenital hemangioma.},
language = {eng},
number = {9},
journal = {Journal of Pediatric Surgery},
author = {Boon, L. M. and Fishman, S. J. and Lund, D. P. and Mulliken, J. B.},
month = sep,
year = {1995},
pmid = {8523253},
keywords = {Diagnosis, Differential, Female, Fibrosarcoma, Hemangioma, Humans, Infant, Newborn, Male, Neck, Shoulder, Skin Neoplasms},
pages = {1378--1381}
}The risk of sulfasalazine- and mesalazine-associated blood disorders. Jick, H., Myers, M. W., & Dean, A. D. Pharmacotherapy, 15(2):176--181, April, 1995.
abstract bibtex
abstract bibtex
Sulfasalazine (SASP) has often been reported to cause serious blood disorders, particularly agranulocytosis; however, little quantitative information is available to estimate the risk or to identify possible modifiers of the risk. We used comprehensive clinical information recorded on office computers by selected general practitioners in Britain to conduct a follow-up study of some 10,000 users of SASP and some 4000 users of mesalazine to estimate the risk of blood disorders associated with these drugs. Overall, the frequency of blood disorders attributable to SASP was 27/10,332 (2.6/1000 users). The risk for SASP users who were treated for arthritic disorders (6.1/1000 users) was some 10 times higher than that for users who were treated for inflammatory bowel disease (0.6/1000 users). There were no cases of blood disorders in users of mesalazine.
@article{jick_risk_1995,
title = {The risk of sulfasalazine- and mesalazine-associated blood disorders},
volume = {15},
issn = {0277-0008},
abstract = {Sulfasalazine (SASP) has often been reported to cause serious blood disorders, particularly agranulocytosis; however, little quantitative information is available to estimate the risk or to identify possible modifiers of the risk. We used comprehensive clinical information recorded on office computers by selected general practitioners in Britain to conduct a follow-up study of some 10,000 users of SASP and some 4000 users of mesalazine to estimate the risk of blood disorders associated with these drugs. Overall, the frequency of blood disorders attributable to SASP was 27/10,332 (2.6/1000 users). The risk for SASP users who were treated for arthritic disorders (6.1/1000 users) was some 10 times higher than that for users who were treated for inflammatory bowel disease (0.6/1000 users). There were no cases of blood disorders in users of mesalazine.},
language = {eng},
number = {2},
journal = {Pharmacotherapy},
author = {Jick, H. and Myers, M. W. and Dean, A. D.},
month = apr,
year = {1995},
pmid = {7624265},
keywords = {Adolescent, Adult, Aged, Agranulocytosis, Aminosalicylic Acids, Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Child, Child, Preschool, Female, Follow-Up Studies, Great Britain, Hematologic Diseases, Humans, Infant, Inflammatory Bowel Diseases, Male, Mesalamine, Middle Aged, Product Surveillance, Postmarketing, Risk Factors, Sulfasalazine},
pages = {176--181}
}1989 (2)
Diagnostic arthroscopy of the knee in children and adolescents. Harvell, J., Fu, F H, & Stanitski, C L Orthopedics, 12(12):1555--1560, December, 1989. 00000
abstract bibtex
abstract bibtex
There is a definite role for arthroscopy in the diagnosis and treatment of problem knees in children and adolescents. In this series, the largest reported to date, significant intraarticular pathology frequently existed in both preadolescent and adolescent groups. Three hundred ten knee arthroscopies in 285 children were reviewed. Preoperative clinical diagnoses were correlated with arthroscopic findings. In preadolescents (12 years old and younger), only 55% of preoperative clinical diagnoses were confirmed at surgery. Thirty-five percent of this group were found to have additional pathology not anticipated preoperatively. In adolescents (13 to 18 years old), 70% of clinical diagnoses were confirmed arthroscopically. Additional pathology was also found on arthroscopic examination in 25% of this group.
@article{harvell_diagnostic_1989,
title = {Diagnostic arthroscopy of the knee in children and adolescents},
volume = {12},
issn = {0147-7447},
abstract = {There is a definite role for arthroscopy in the diagnosis and treatment of problem knees in children and adolescents. In this series, the largest reported to date, significant intraarticular pathology frequently existed in both preadolescent and adolescent groups. Three hundred ten knee arthroscopies in 285 children were reviewed. Preoperative clinical diagnoses were correlated with arthroscopic findings. In preadolescents (12 years old and younger), only 55\% of preoperative clinical diagnoses were confirmed at surgery. Thirty-five percent of this group were found to have additional pathology not anticipated preoperatively. In adolescents (13 to 18 years old), 70\% of clinical diagnoses were confirmed arthroscopically. Additional pathology was also found on arthroscopic examination in 25\% of this group.},
language = {eng},
number = {12},
journal = {Orthopedics},
author = {Harvell, Jr, J C and Fu, F H and Stanitski, C L},
month = dec,
year = {1989},
pmid = {2594588},
note = {00000 },
keywords = {Adolescent, Arthroscopy, Cartilage Diseases, Child, Child, Preschool, Female, Humans, Infant, Joint Diseases, Knee Joint, Male, Retrospective Studies, knee injuries},
pages = {1555--1560}
}Hyperkalaemia in patients in hospital. Moore, M. L. & Bailey, R. R. The New Zealand Medical Journal, 102(878):557–558, October, 1989.
abstract bibtex
abstract bibtex
A survey of all laboratory blood specimens with a plasma potassium concentration greater than or equal to 5.5 mmol/L was conducted over a three month period. Of 331 specimens with hyperkalaemia, 71 were excluded because the specimens was haemolysed, old or contaminated. The laboratory served a population of 348,561 and during this time measured the plasma potassium on 25,016 occasions. Sixty-six outpatients and 20 neonates were not evaluated. The survey was undertaken on 86 of 102 inpatients (46 males), 48 of whom were over 66 years of age. Fifty-seven patients were admitted under a medical service and 29 under a surgical service. Fifty-nine had a single episode of hyperkalaemia. Thirty-two underwent a surgical procedure. The commonest contributing factor was impaired renal function which was present in 71 (83%) patients. Although a definitive causative role for drugs could be identified in only five patients, in 52 (60%) patients drugs were a contributing factor (potassium supplements 24, ACE inhibitors 16, nonsteroidal antiinflammatory drugs 12). Thirty-five of the 86 (41%) patients died during their hospital admission. Nineteen of the 35 deaths occurred within three days of the hyperkalaemia being recorded. A normal plasma potassium was eventually documented in 50 of the 86 patients. Of the remaining 36 patients, 25 (69%) subsequently died. In general the treatment of patients with hyperkalaemia focused on identifying and treating the underlying cause. Hyperkalaemia must always be considered seriously and regard given to the overall clinical status of the patient, with particular attention to drug therapy, renal and cardiac function, acid base status and the possibility of sepsis.
@article{moore_hyperkalaemia_1989,
title = {Hyperkalaemia in patients in hospital},
volume = {102},
issn = {0028-8446},
abstract = {A survey of all laboratory blood specimens with a plasma potassium concentration greater than or equal to 5.5 mmol/L was conducted over a three month period. Of 331 specimens with hyperkalaemia, 71 were excluded because the specimens was haemolysed, old or contaminated. The laboratory served a population of 348,561 and during this time measured the plasma potassium on 25,016 occasions. Sixty-six outpatients and 20 neonates were not evaluated. The survey was undertaken on 86 of 102 inpatients (46 males), 48 of whom were over 66 years of age. Fifty-seven patients were admitted under a medical service and 29 under a surgical service. Fifty-nine had a single episode of hyperkalaemia. Thirty-two underwent a surgical procedure. The commonest contributing factor was impaired renal function which was present in 71 (83\%) patients. Although a definitive causative role for drugs could be identified in only five patients, in 52 (60\%) patients drugs were a contributing factor (potassium supplements 24, ACE inhibitors 16, nonsteroidal antiinflammatory drugs 12). Thirty-five of the 86 (41\%) patients died during their hospital admission. Nineteen of the 35 deaths occurred within three days of the hyperkalaemia being recorded. A normal plasma potassium was eventually documented in 50 of the 86 patients. Of the remaining 36 patients, 25 (69\%) subsequently died. In general the treatment of patients with hyperkalaemia focused on identifying and treating the underlying cause. Hyperkalaemia must always be considered seriously and regard given to the overall clinical status of the patient, with particular attention to drug therapy, renal and cardiac function, acid base status and the possibility of sepsis.},
language = {eng},
number = {878},
journal = {The New Zealand Medical Journal},
author = {Moore, M. L. and Bailey, R. R.},
month = oct,
year = {1989},
pmid = {2812582},
keywords = {Adolescent, Aged, Aged, 80 and over, Female, Follow-Up Studies, Hospitalization, Humans, Hyperkalemia, Infant, Male, Medical Audit, Middle Aged, New Zealand, Retrospective Studies, Sampling Studies, Time Factors},
pages = {557--558}
}1988 (1)
The Intergroup Rhabdomyosarcoma Study-I. A final report. Maurer, H. M., Beltangady, M., Gehan, E. A., Crist, W., Hammond, D., Hays, D. M., Heyn, R., Lawrence, W., Newton, W., & Ortega, J. Cancer, 61(2):209--220, January, 1988.
abstract bibtex
abstract bibtex
The results of treatment of 686, previously untreated patients younger than 21 years with rhabdomyosarcoma or undifferentiated sarcoma, who were entered on Intergroup Rhabdomyosarcoma Study-I (IRS-I) were analyzed after a minimum potential follow-up time of 7 years. Patients in Clinical Group I (localized disease, completely resected) were randomized to receive either vincristine, dactinomycin, and cyclophosphamide (VAC) or VAC + radiation. At 5 years, approximately 80% of patients given either treatment were still disease-free and there was no significant difference between treatments in the overall percentages of patients surviving of 93% and 81%, respectively (P = 0.67). Patients in Clinical Group II (regional disease, grossly resected) were randomized to receive either vincristine and dactinomycin (VA) + radiation or VAC + radiation. At 5 years, 72% and 65% of the patients, respectively, were disease-free and there was no evidence of a difference between treatments (P = 0.46). The overall survival percentage at 5 years was approximately 72% for both treatments. Patients in Clinical Groups III (gross residual disease after surgery) and IV (metastatic disease) were randomized to receive either "pulse" VAC + radiation or "pulse" VAC + Adriamycin (doxorubicin) + radiation. The complete remission (CR) rate was 69% in Clinical Group III and 50% in IV, with no statistically significant difference in CR rates between treatments in either group. Those who achieved a CR had a nearly 60% chance of staying in remission for 5 years in Clinical Group III compared with approximately 30% in Clinical Group IV. The overall survival percentage at 5 years was 52% in Clinical Group III compared to 20% in Clinical Group IV (P less than 0.0001). The 5-year survival percentage for the entire cohort of 686 patients was 55%. Survival after relapse was poor, being 32% at 1 year and 17% at 2 years. The risk of distant metastasis was much greater than the risk of local recurrence within each clinical group, and there was no evidence of differing types of relapses between treatments. Primary tumors of the orbit and genitourinary tract carried the best prognosis, whereas tumors of the retroperitoneum had the worst prognosis. The authors conclude that for the therapeutic regimens evaluated there was no therapeutic advantage to including radiation in the treatment of Clinical Group I disease, or cyclophosphamide given as a daily low-dose oral regimen in the treatment of Clinical Group II disease or Adriamycin in the treatment of Clinical Groups III and IV diseases.
@article{maurer_intergroup_1988,
title = {The {Intergroup} {Rhabdomyosarcoma} {Study}-{I}. {A} final report},
volume = {61},
issn = {0008-543X},
abstract = {The results of treatment of 686, previously untreated patients younger than 21 years with rhabdomyosarcoma or undifferentiated sarcoma, who were entered on Intergroup Rhabdomyosarcoma Study-I (IRS-I) were analyzed after a minimum potential follow-up time of 7 years. Patients in Clinical Group I (localized disease, completely resected) were randomized to receive either vincristine, dactinomycin, and cyclophosphamide (VAC) or VAC + radiation. At 5 years, approximately 80\% of patients given either treatment were still disease-free and there was no significant difference between treatments in the overall percentages of patients surviving of 93\% and 81\%, respectively (P = 0.67). Patients in Clinical Group II (regional disease, grossly resected) were randomized to receive either vincristine and dactinomycin (VA) + radiation or VAC + radiation. At 5 years, 72\% and 65\% of the patients, respectively, were disease-free and there was no evidence of a difference between treatments (P = 0.46). The overall survival percentage at 5 years was approximately 72\% for both treatments. Patients in Clinical Groups III (gross residual disease after surgery) and IV (metastatic disease) were randomized to receive either "pulse" VAC + radiation or "pulse" VAC + Adriamycin (doxorubicin) + radiation. The complete remission (CR) rate was 69\% in Clinical Group III and 50\% in IV, with no statistically significant difference in CR rates between treatments in either group. Those who achieved a CR had a nearly 60\% chance of staying in remission for 5 years in Clinical Group III compared with approximately 30\% in Clinical Group IV. The overall survival percentage at 5 years was 52\% in Clinical Group III compared to 20\% in Clinical Group IV (P less than 0.0001). The 5-year survival percentage for the entire cohort of 686 patients was 55\%. Survival after relapse was poor, being 32\% at 1 year and 17\% at 2 years. The risk of distant metastasis was much greater than the risk of local recurrence within each clinical group, and there was no evidence of differing types of relapses between treatments. Primary tumors of the orbit and genitourinary tract carried the best prognosis, whereas tumors of the retroperitoneum had the worst prognosis. The authors conclude that for the therapeutic regimens evaluated there was no therapeutic advantage to including radiation in the treatment of Clinical Group I disease, or cyclophosphamide given as a daily low-dose oral regimen in the treatment of Clinical Group II disease or Adriamycin in the treatment of Clinical Groups III and IV diseases.},
language = {eng},
number = {2},
journal = {Cancer},
author = {Maurer, H. M. and Beltangady, M. and Gehan, E. A. and Crist, W. and Hammond, D. and Hays, D. M. and Heyn, R. and Lawrence, W. and Newton, W. and Ortega, J.},
month = jan,
year = {1988},
pmid = {3275486},
keywords = {Adolescent, Antineoplastic Combined Chemotherapy Protocols, Child, Child, Preschool, Clinical Trials as Topic, Combined Modality Therapy, Cyclophosphamide, Dactinomycin, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Female, Follow-Up Studies, Humans, Infant, Male, Prognosis, Random Allocation, Rhabdomyosarcoma, Vincristine},
pages = {209--220}
}1985 (1)
Perinatal (Congenital and Neonatal) Neoplasms: A Report of 110 Cases. Isaacs, H. Pediatric Pathology, 3(2-4):165--216, January, 1985.
Paper doi abstract bibtex
Paper doi abstract bibtex One hundred ten congenital and neonatal tumors encompassing a 25-year period are described and compared with similar published cases. Forty percent are classified as histologically malignant, and 65% of neonates with malignancies died. The types, frequency, and clinical features of neoplasms encountered in the perinatal period are markedly different from those observed in older children and adolescents. Their biological behavior and response to therapy are also dissimilar. Leukemia was responsible for the largest number of deaths followed by neuroblastoma and brain tumors.
@article{isaacs_perinatal_1985,
title = {Perinatal ({Congenital} and {Neonatal}) {Neoplasms}: {A} {Report} of 110 {Cases}},
volume = {3},
issn = {0277-0938},
shorttitle = {Perinatal ({Congenital} and {Neonatal}) {Neoplasms}},
url = {http://proxy.library.upenn.edu:2340/doi/abs/10.3109/15513818509078782},
doi = {10.3109/15513818509078782},
abstract = {One hundred ten congenital and neonatal tumors encompassing a 25-year period are described and compared with similar published cases. Forty percent are classified as histologically malignant, and 65\% of neonates with malignancies died. The types, frequency, and clinical features of neoplasms encountered in the perinatal period are markedly different from those observed in older children and adolescents. Their biological behavior and response to therapy are also dissimilar. Leukemia was responsible for the largest number of deaths followed by neuroblastoma and brain tumors.},
language = {eng},
number = {2-4},
urldate = {2016-02-10TZ},
journal = {Pediatric Pathology},
author = {Isaacs, Hart},
month = jan,
year = {1985},
pmid = {3879355},
keywords = {Brain Neoplasms, Carcinoma, Eye Neoplasms, Female, Fibrosarcoma, Hemangiopericytoma, Histiocytosis, Langerhans-Cell, Humans, Infant, Newborn, Kidney Neoplasms, Leukemia, Liver Neoplasms, Male, Neoplasms, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Soft Tissue Neoplasms, Teratoma},
pages = {165--216}
}1980 (1)
Emergency room care of the poisoned child. Greensher, J. & Mofenson, H. C. Issues in Comprehensive Pediatric Nursing, 4(3):1--21, June, 1980.
bibtex
bibtex
@article{greensher_emergency_1980,
title = {Emergency room care of the poisoned child},
volume = {4},
issn = {0146-0862},
language = {eng},
number = {3},
journal = {Issues in Comprehensive Pediatric Nursing},
author = {Greensher, J. and Mofenson, H. C.},
month = jun,
year = {1980},
pmid = {6900625},
keywords = {Antidotes, Child, Child, Preschool, Emergency Medical Services, Emergency Service, Hospital, Household Products, Humans, Infant, Plant Poisoning, Poisoning},
pages = {1--21}
}1978 (1)
The treatment of poisoning. Arena, J. M. Clinical Symposia (Summit, N.J.: 1957), 30(2):1--47, 1978.
bibtex
bibtex
@article{arena_treatment_1978,
title = {The treatment of poisoning},
volume = {30},
issn = {0009-9295},
language = {eng},
number = {2},
journal = {Clinical Symposia (Summit, N.J.: 1957)},
author = {Arena, J. M.},
year = {1978},
pmid = {753572},
keywords = {Acetaminophen, Acids, Antidotes, Aspirin, Barbiturates, Carbon Tetrachloride Poisoning, Child, Child, Preschool, Digitalis Glycosides, Emetics, Gastric Lavage, Household Products, Humans, Hypnotics and Sedatives, Infant, Insecticides, Lye, Metals, Morphine, Oxalates, Plant Poisoning, Poisoning, Renal Dialysis, Rodenticides, Tranquilizing Agents},
pages = {1--47}
}1977 (1)
Fibrosarcoma in infants and children: a review of 110 cases. Soule, E. H. & Pritchard, D. J. Cancer, 40(4):1711--1721, October, 1977.
abstract bibtex
abstract bibtex
This retrospective study summarizes the clinicopathologic findings in 110 children with fibrosarcoma. Seventy cases were selected from previous reports and 40 were from our files. The histologic criteria used for diagnosis are the same as those used for adults. Sixty-eight patients were in the first quinquennium of life, 13 in the second, and 29 in the third. Eleven patients died of their tumor, three in the first quinquennium and eight in ght third. Our findings indicate that children who are less than 5 years old have a 7.3% chance of developing metastatic spread even though the local recurrence rate is 43%. Children who are 10 years old or older had a metastatic rate of 50% at 5-year follow-up, a figure closely approximating that for adults. We believe that infants and children less than 5 years old may be treated initially by local excision of the lesion, without sacrificing significant function of the part. Recurrent tumor does not seem to predispose to metastatic disease.
@article{soule_fibrosarcoma_1977,
title = {Fibrosarcoma in infants and children: a review of 110 cases},
volume = {40},
issn = {0008-543X},
shorttitle = {Fibrosarcoma in infants and children},
abstract = {This retrospective study summarizes the clinicopathologic findings in 110 children with fibrosarcoma. Seventy cases were selected from previous reports and 40 were from our files. The histologic criteria used for diagnosis are the same as those used for adults. Sixty-eight patients were in the first quinquennium of life, 13 in the second, and 29 in the third. Eleven patients died of their tumor, three in the first quinquennium and eight in ght third. Our findings indicate that children who are less than 5 years old have a 7.3\% chance of developing metastatic spread even though the local recurrence rate is 43\%. Children who are 10 years old or older had a metastatic rate of 50\% at 5-year follow-up, a figure closely approximating that for adults. We believe that infants and children less than 5 years old may be treated initially by local excision of the lesion, without sacrificing significant function of the part. Recurrent tumor does not seem to predispose to metastatic disease.},
language = {eng},
number = {4},
journal = {Cancer},
author = {Soule, E. H. and Pritchard, D. J.},
month = oct,
year = {1977},
pmid = {561651},
keywords = {Adolescent, Age Factors, Child, Child, Preschool, Fibrosarcoma, Humans, Infant, Infant, Newborn, Neoplasm Metastasis, Neoplasm Recurrence, Local, Retrospective Studies},
pages = {1711--1721}
}1976 (2)
Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth: a controlled, prospective trial. Bland, R. D., Clarke, T. L., & Harden, L. B. American Journal of Obstetrics and Gynecology, 124(3):263–267, February, 1976.
abstract bibtex
abstract bibtex
We conducted a controlled, prospective trial to evaluate the effectiveness of rapidly infusing sodium bicarbonate (NaHCO3) and salt-poor albumin into high-risk, premature infants in the first 2 hours of life. Fifty-three infants, randomized into one of four treatment groups, received 8 ml. per kilogram of a solution containing either (A) glucose in water, (B) salt-poor albumin, (C) NaHCO3, or (D) a combination of albumin and NaHCO3. After the initial infusion, the babies received no colloid or alkali solutions until 4 hours of age. We managed them supportively with warmth, appropriate oxygen administration, isotonic fluid infusion, and close monitoring. Among the infants who received alkali, 14 of 26 acquired the respiratory distress syndrome (RDS), 11 died, and four had intracranial hemorrhage. Among babies who received no alkali, RDS occurred in 11 of 27, 5 died, and none had intracranial hemorrhage. These results do not support the common practice of rapidly infusing NaHCO3 into high-risk, premature infants, and they suggest that the early management of such infants needs renewed critical evaluation.
@article{bland_rapid_1976,
title = {Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth: a controlled, prospective trial},
volume = {124},
issn = {0002-9378},
shorttitle = {Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth},
abstract = {We conducted a controlled, prospective trial to evaluate the effectiveness of rapidly infusing sodium bicarbonate (NaHCO3) and salt-poor albumin into high-risk, premature infants in the first 2 hours of life. Fifty-three infants, randomized into one of four treatment groups, received 8 ml. per kilogram of a solution containing either (A) glucose in water, (B) salt-poor albumin, (C) NaHCO3, or (D) a combination of albumin and NaHCO3. After the initial infusion, the babies received no colloid or alkali solutions until 4 hours of age. We managed them supportively with warmth, appropriate oxygen administration, isotonic fluid infusion, and close monitoring. Among the infants who received alkali, 14 of 26 acquired the respiratory distress syndrome (RDS), 11 died, and four had intracranial hemorrhage. Among babies who received no alkali, RDS occurred in 11 of 27, 5 died, and none had intracranial hemorrhage. These results do not support the common practice of rapidly infusing NaHCO3 into high-risk, premature infants, and they suggest that the early management of such infants needs renewed critical evaluation.},
language = {eng},
number = {3},
journal = {American Journal of Obstetrics and Gynecology},
author = {Bland, R. D. and Clarke, T. L. and Harden, L. B.},
month = feb,
year = {1976},
pmid = {2013},
keywords = {Acidosis, Albumins, Bicarbonates, Carbon Dioxide, Cerebral Hemorrhage, Female, Hawaii, Humans, Hydrogen-Ion Concentration, Infant, Newborn, Infant, Premature, Diseases, Infusions, Parenteral, Male, Prospective Studies, Respiratory Distress Syndrome, Newborn, Sodium, Time Factors},
pages = {263--267}
}Infantile fibrosarcoma. Chung, E. B. & Enzinger, F. M. Cancer, 38(2):729--739, August, 1976.
abstract bibtex
abstract bibtex
The pathologic features and the behavior of 53 cases of infantile fibrosarcoma are presented. The tumor nearly always occurred during the first 2 years of life; 41 of the 53 cases occurred during the first, six during the second, and three each during the third and fourth year of life, respectively. Twenty of the 53 cases were present at birth. The tumor was more common in boys (60%) and affected chiefly the distal portions of the lower and upper extremities (72%). Most of the tumors grew rapidly and reached a large size within a few weeks or months. They were generally poorly circumscribed and infiltrated variously subcutaneous fat, muscle, fascia and tendons. Microscopically, they were composed of immature-appearing spindle-shaped cells and were marked by their high cellularity and prominent mitotic activity. Despite these features, follow-up information revealed a favorable clinical course, particularly as compared with the adult form of fibrosarcoma. Of the 48 patients with follow-up data, 31 were alive and well with no evidence of recurrence, eight were alive with recurrence, and one was alive following lobectomy for metastatic tumor. Of the living patients, 12 were treated with amputation, nine with radical or wide local excision, and 15 with simple excision. In two cases surgery was followed by chemotherapy, and in one, by radiotherapy. Eight of the 48 patients with follow-up had died, four of metastatic tumor (8.3%) and four of miscellaneous causes. Wide local excision appears to be the treatment of choice unless the size of the tumor and its anatomic location require amputation. Since late recurrent and metastatic lesions were encountered, long-term followup is necessary before one can safely assume that the patient has been cured.
@article{chung_infantile_1976,
title = {Infantile fibrosarcoma},
volume = {38},
issn = {0008-543X},
abstract = {The pathologic features and the behavior of 53 cases of infantile fibrosarcoma are presented. The tumor nearly always occurred during the first 2 years of life; 41 of the 53 cases occurred during the first, six during the second, and three each during the third and fourth year of life, respectively. Twenty of the 53 cases were present at birth. The tumor was more common in boys (60\%) and affected chiefly the distal portions of the lower and upper extremities (72\%). Most of the tumors grew rapidly and reached a large size within a few weeks or months. They were generally poorly circumscribed and infiltrated variously subcutaneous fat, muscle, fascia and tendons. Microscopically, they were composed of immature-appearing spindle-shaped cells and were marked by their high cellularity and prominent mitotic activity. Despite these features, follow-up information revealed a favorable clinical course, particularly as compared with the adult form of fibrosarcoma. Of the 48 patients with follow-up data, 31 were alive and well with no evidence of recurrence, eight were alive with recurrence, and one was alive following lobectomy for metastatic tumor. Of the living patients, 12 were treated with amputation, nine with radical or wide local excision, and 15 with simple excision. In two cases surgery was followed by chemotherapy, and in one, by radiotherapy. Eight of the 48 patients with follow-up had died, four of metastatic tumor (8.3\%) and four of miscellaneous causes. Wide local excision appears to be the treatment of choice unless the size of the tumor and its anatomic location require amputation. Since late recurrent and metastatic lesions were encountered, long-term followup is necessary before one can safely assume that the patient has been cured.},
language = {eng},
number = {2},
journal = {Cancer},
author = {Chung, E. B. and Enzinger, F. M.},
month = aug,
year = {1976},
pmid = {974993},
keywords = {Child, Preschool, Extremities, Female, Fibrosarcoma, Follow-Up Studies, Head and Neck Neoplasms, Humans, Infant, Infant, Newborn, Infant, Newborn, Diseases, Male, Neoplasm Metastasis, Neoplasm Recurrence, Local, Remission, Spontaneous},
pages = {729--739}
}1971 (1)
Enteric duplications. Thirty-seven cases: a vascular theory of pathogenesis. Favara, B. E., Franciosi, R. A., & Akers, D. R. American Journal of Diseases of Children (1960), 122(6):501--506, December, 1971.
bibtex
bibtex
@article{favara_enteric_1971,
title = {Enteric duplications. {Thirty}-seven cases: a vascular theory of pathogenesis},
volume = {122},
issn = {0002-922X},
shorttitle = {Enteric duplications. {Thirty}-seven cases},
language = {eng},
number = {6},
journal = {American Journal of Diseases of Children (1960)},
author = {Favara, B. E. and Franciosi, R. A. and Akers, D. R.},
month = dec,
year = {1971},
pmid = {5145872},
keywords = {Child, Child, Preschool, Female, Humans, Ileum, Infant, Infant, Newborn, Intestinal Atresia, Intestinal Mucosa, Intestine, Small, Male, Mesenteric Vascular Occlusion, Pregnancy, Vomiting},
pages = {501--506}
}