@article{xiao_vitro_2022,
	title = {In {Vitro} {ADME} and {Preclinical} {Pharmacokinetics} of {Ulotaront}, a {TAAR1}/5-{HT1A} {Receptor} {Agonist} for the {Treatment} of {Schizophrenia}},
	volume = {39},
	issn = {1573-904X},
	doi = {10.1007/s11095-022-03267-1},
	abstract = {PURPOSE: Ulotaront (SEP-363856) is a TAAR1 agonist with 5-HT1A agonist activity currently in clinical development for the treatment of schizophrenia. The objectives of the current study were to characterize the in vitro ADME properties, preclinical PK, and to evaluate the DDI potential of ulotaront and its major metabolite SEP-383103.
METHODS: Solubility, permeability, plasma protein binding, CYP inhibition and induction, transporter inhibition and uptake studies were conducted in vitro. Phenotyping studies were conducted using recombinant human CYPs and FMOs, human liver microsomes and human liver homogenates. Preclinical plasma and brain pharmacokinetics were determined after a single intraperitoneal, intravenous, and oral administration of ulotaront.
RESULTS: Ulotaront is a compound of high solubility, high permeability, and low binding to plasma proteins. Ulotaront metabolism is mediated via both NADPH-dependent and NADPH-independent pathways, with CYP2D6 as the major metabolizing enzyme. Ulotaront is an inducer of CYP2B6, and an inhibitor of CYP2D6, OCT1 and OCT2, while SEP-383103 is neither a CYP inducer nor a potent inhibitor of CYPs and human transporters. Ulotaront exhibits rapid absorption, greater than 70\% bioavailability, approximately 3.5 L/kg volume of distribution, 1.5-4 h half-life, 12-43 ml/min/kg clearance, and good penetration across the blood-brain barrier in preclinical species.
CONCLUSIONS: Ulotaront has been designated as a BCS1 compound by US FDA. The ability of ulotaront to penetrate the blood-brain barrier for CNS targeting has been demonstrated in mice and rats. The potential for ulotaront and SEP-383103 to act as perpetrators of CYP and transporter-mediated DDIs is predicted to be remote.},
	language = {eng},
	number = {5},
	journal = {Pharmaceutical Research},
	author = {Xiao, Guangqing and Chen, Yu-Luan and Dedic, Nina and Xie, Linghong and Koblan, Kenneth S. and Galluppi, Gerald R.},
	month = may,
	year = {2022},
	pmid = {35484370},
	keywords = {Animals, CYP2D6, Cytochrome P-450 CYP2D6, Cytochrome P-450 Enzyme System, Mice, Microsomes, Liver, NADP, Pharmaceutical Preparations, Rats, Receptor, Serotonin, 5-HT1A, Schizophrenia, TAAR1, blood–brain barrier, drug-drug interactions, phenotyping, ulotaront},
	pages = {837--850},
}

@article{raina_synthetic_2020,
	title = {Synthetic hydroxyapatite: a recruiting platform for biologically active molecules.},
	volume = {91},
	issn = {1745-3682 1745-3674 1745-3674},
	doi = {10.1080/17453674.2019.1686865},
	abstract = {Background and purpose - Targeted delivery of drugs is important to achieve  efficient local concentrations and reduce systemic side effects. We hypothesized  that locally implanted synthetic hydroxyapatite (HA) particles can act as a  recruiting moiety for systemically administered drugs, leading to targeted drug  accretion.Methods - Synthetic HA particles were implanted ectopically in a muscle  pouch in rats, and the binding of systemically circulating drugs such as zoledronic  acid (ZA), tetracycline and (18)F-fluoride ((18)F) was studied. The local biological  effect was verified in an implant integration model in rats, wherein a hollow  implant was filled with synthetic HA particles and the animals were given systemic  ZA, 2-weeks post-implantation. The effect of HA particle size on drug binding and  the possibility of reloading HA particles were also evaluated in the muscle  pouch.Results - The systemically administered biomolecules (ZA, tetracycline and  (18)F) all sought the HA moiety placed in the muscle pouch. Statistically  significant higher peri-implant bone volume and peak force were observed in the  implant containing HA particles compared with the empty implant. After a single  injection of ZA at 2 weeks, micro HA particles showed a tendency to accumulate more  (14)C-zoledronic acid ((14)C-ZA) than nano-HA particles in the muscle pouch. HA  particles could be reloaded when ZA was given again at 4 weeks, showing increased  (14)C-ZA accretion by 73\% in microparticles and 77\% in nanoparticles.Interpretation  - We describe a novel method of systemic drug loading resulting in targeted  accretion in locally implanted particulate HA, thereby biologically activating the  material.},
	language = {eng},
	number = {2},
	journal = {Acta orthopaedica},
	author = {Raina, Deepak Bushan and Liu, Yang and Isaksson, Hanna and Tägil, Magnus and Lidgren, Lars},
	month = apr,
	year = {2020},
	pmid = {31680611},
	pmcid = {PMC7144254},
	keywords = {*Drug Delivery Systems, Animals, Anti-Bacterial Agents/administration \& dosage/pharmacokinetics, Bone Density Conservation Agents/*administration \& dosage/pharmacokinetics, Coated Materials, Biocompatible, Drug Carriers, Durapatite/*metabolism, Fluorides/administration \& dosage/pharmacokinetics, Implants, Experimental, Male, Particle Size, Positron Emission Tomography Computed Tomography, Rats, Sprague-Dawley, Tetracycline/administration \& dosage/pharmacokinetics, Zoledronic Acid/*administration \& dosage/pharmacokinetics},
	pages = {126--132},
}

@article{raina_gelatin-_2018,
	title = {Gelatin- hydroxyapatite- calcium sulphate based biomaterial for long term sustained delivery of bone morphogenic protein-2 and zoledronic acid for increased bone formation: {In}-vitro and in-vivo carrier properties},
	volume = {272},
	issn = {1873-4995},
	doi = {10.1016/j.jconrel.2018.01.006},
	abstract = {In this study, a novel macroporous composite biomaterial consisting of gelatin-hydroxyapatite-calcium sulphate for delivery of bone morphogenic protein-2 (rhBMP-2) and zoledronic acid (ZA) has been developed. The biomaterial scaffold has a porous structure and functionalization of the scaffold with rhBMP-2 induces osteogenic differentiation of MC3T3-e1 cells seen by a significant increase in biochemical and genetic markers of osteoblastic differentiation. In-vivo muscle pouch experiments showed higher mineralization using scaffold+rhBMP-2 when compared to an approved absorbable collagen sponge (ACS)+rhBMP-2 as verified by micro-CT. Co-delivery of rhBMP-2+ZA via the novel scaffold enabled a reduction in the effective rhBMP-2 doses. The presence of tartrate resistant acid phosphatase staining in the rhBMP-2 group indicates osteoclastic resorption, which could be stalled by adding ZA, which by speculation could explain the net increase in mineralization. The new scaffold allowed for slow release of rhBMP-2 in-vitro (3.3±0.1\%) after 4weeks. Using single photon emission computed tomography (SPECT), the release kinetics of 125I-rhBMP-2 in-vivo was followed for 4weeks and a total of 65.3±15.2\% 125I-rhBMP-2 was released from the scaffolds. In-vitro 14C-ZA release curve shows an initial burst release on day 1 (8.8±0.7\%) followed by a slow release during the following 4weeks (13±0.1\%). In-vivo, an initial release of 43.2±7.6\% of 14C-ZA was detected after 1day, after which the scaffold retained the remaining ZA during 4-weeks. Taken together, our results show that the developed biomaterial is an efficient carrier for spatio-temporal delivery of rhBMP-2 and ZA leading to increased bone formation compared to commercially available carrier for rhBMP-2.},
	language = {eng},
	journal = {Journal of Controlled Release: Official Journal of the Controlled Release Society},
	author = {Raina, Deepak Bushan and Larsson, David and Mrkonjic, Filip and Isaksson, Hanna and Kumar, Ashok and Lidgren, Lars and Tägil, Magnus},
	year = {2018},
	pmid = {29329716},
	keywords = {Animals, Biocompatible Materials, Bone Density Conservation Agents, Bone Morphogenetic Protein 2, Bone morphogenic protein (BMP), Calcium Sulfate, Cell Line, Cell Survival, Cryogels, Delayed-Action Preparations, Durapatite, Gelatin, Hydroxyapatite, In-vivo BMP release, In-vivo ZA release, Male, Mice, Osteogenesis, Rats, Sprague-Dawley, Recombinant Proteins, Transforming Growth Factor beta, Zoledronic Acid, Zoledronic acid (ZA)},
	pages = {83--96},
}

@article{dujardin_different_2018,
	title = {Different tau species lead to heterogeneous tau pathology propagation and misfolding},
	volume = {6},
	issn = {2051-5960},
	doi = {10.1186/s40478-018-0637-7},
	abstract = {Tauopathies are a heterogeneous group of pathologies characterized by tau aggregation inside neurons. Most of them are sporadic but certain tauopathies rely on tau gene (MAPT) mutations. They particularly differ from one to another by their different neuropathological signatures e.g. lesion shapes, regions affected and molecular composition of aggregates. Six isoforms of tau exist, but they do not all co-aggregate in each tauopathy but rather have a unique signature for each one. In some tauopathies such as Alzheimer's disease (AD), tau protein aggregation follows stereotypical anatomical stages. Recent data suggest that this progression is due to an active process of tau protein propagation from neuron-to-neuron. We wondered how tau isoforms or mutations could influence the process of tau aggregation and tau propagation. In human neuropathological material, we found that MAPT mutations induce a faster misfolding compared to tau found in sporadic AD patients. In the rat brain, we observed cell-to-cell transfer of non-pathological tau species irrespective of the tested isoform or presence of a mutation. By contrast, we found that the species of tau impact the propagation of tau pathology markers such as hyperphosphorylation and misfolding. Indeed, misfolding and hyperphosphorylated tau proteins do not spread at the same rate when tau is mutated, or the isoform composition is modified. These results clearly argue for the existence of specific folding properties of tau depending on isoforms or mutations impacting the behavior of pathological tau species.},
	language = {eng},
	number = {1},
	journal = {Acta Neuropathologica Communications},
	author = {Dujardin, Simon and Bégard, Séverine and Caillierez, Raphaëlle and Lachaud, Cédrick and Carrier, Sébastien and Lieger, Sarah and Gonzalez, Jose A. and Deramecourt, Vincent and Déglon, Nicole and Maurage, Claude-Alain and Frosch, Matthew P. and Hyman, Bradley T. and Colin, Morvane and Buée, Luc},
	month = nov,
	year = {2018},
	pmid = {30497516},
	pmcid = {PMC6263555},
	keywords = {Aged, Humans, Female, Male, Middle Aged, Brain, Alzheimer’s disease, Adult, Disease Progression, tau Proteins, Aged, 80 and over, Animals, Protein Isoforms, Rats, Severity of Illness Index, Mutation, Tauopathies, Disease Models, Animal, Phosphorylation, Rats, Wistar, Propagation, Tau, Heterogeneity, Injections, Intraventricular, Isoforms, Misfolding, Proteostasis Deficiencies},
	pages = {132}
}

Paper  doi  abstract   bibtex   

@article{devaux_proteomic_2016,
	title = {Proteomic {Analysis} of the {Spatio}-temporal {Based} {Molecular} {Kinetics} of {Acute} {Spinal} {Cord} {Injury} {Identifies} a {Time}- and {Segment}-specific {Window} for {Effective} {Tissue} {Repair}},
	volume = {15},
	issn = {1535-9484 (Electronic) 1535-9476 (Linking)},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/27250205},
	doi = {10.1074/mcp.M115.057794},
	abstract = {Spinal cord injury (SCI) represents a major debilitating health issue with a direct socioeconomic burden on the public and private sectors worldwide. Although several studies have been conducted to identify the molecular progression of injury sequel due from the lesion site, still the exact underlying mechanisms and pathways of injury development have not been fully elucidated. In this work, based on OMICs, 3D matrix-assisted laser desorption ionization (MALDI) imaging, cytokines arrays, confocal imaging we established for the first time that molecular and cellular processes occurring after SCI are altered between the lesion proximity, i.e. rostral and caudal segments nearby the lesion (R1-C1) whereas segments distant from R1-C1, i.e. R2-C2 and R3-C3 levels coexpressed factors implicated in neurogenesis. Delay in T regulators recruitment between R1 and C1 favor discrepancies between the two segments. This is also reinforced by presence of neurites outgrowth inhibitors in C1, absent in R1. Moreover, the presence of immunoglobulins (IgGs) in neurons at the lesion site at 3 days, validated by mass spectrometry, may present additional factor that contributes to limited regeneration. Treatment in vivo with anti-CD20 one hour after SCI did not improve locomotor function and decrease IgG expression. These results open the door of a novel view of the SCI treatment by considering the C1 as the therapeutic target.},
	number = {8},
	journal = {Mol Cell Proteomics},
	author = {Devaux, S. and Cizkova, D. and Quanico, J. and Franck, J. and Nataf, S. and Pays, L. and Hauberg-Lotte, L. and Maass, P. and Kobarg, J. H. and Kobeissy, F. and Meriaux, C. and Wisztorski, M. and Slovinska, L. and Blasko, J. and Cigankova, V. and Fournier, I. and Salzet, M.},
	year = {2016},
	keywords = {Animal, Animals, Biomarkers/*metabolism, Cytokines/*metabolism, Disease Models, Humans, Mass, Matrix-Assisted Laser Desorption-Ionization/methods, Protein Array Analysis, Protein Interaction Maps, Proteomics/*methods, Rats, Spectrometry, Spinal Cord Injuries/*metabolism, Time Factors},
	pages = {2641--70},
}

@article{rancan_mri_2016,
	title = {{MRI} {CEST} at {1T} with large µeff {Ln}(3+) complexes {T} m(3+)-{HPDO3A}: {An} efficient {MRI} {pH} reporter},
	volume = {75},
	issn = {1522-2594},
	shorttitle = {{MRI} {CEST} at {1T} with large µeff {Ln}(3+) complexes {T} m(3+)-{HPDO3A}},
	doi = {10.1002/mrm.25589},
	abstract = {PURPOSE: Chemical exchange saturation transfer (CEST) sensitivity relies on the prototropic exchange rate kex between the agent and the "bulk" water protons. To exploit large kex, a large frequency separation (Δω) between the pools of exchanging protons is necessary. For this reason, high magnetic fields are preferred. Herein it is shown that the use of paramagnetic CEST agents based on lanthanide (III) ions with large effective magnetic moments allows the carrying out of CEST experiments at the relatively low field strength of 1 tesla (T).
METHODS: Measurements were performed on a 1T MR-scanner using continuous wave (cw)-presaturation with a spin echo sequence. ParaCEST complexes have been synthetized by mixing the ligand and Ln(III)Cl3 in a stoichiometric ratio at room temperature and pH 7.
RESULTS: Different lanthanide chelates were investigated (Tm-, Dy-, Yb-, Eu-HPDO3A, and Eu-DOTAMGly). Ratiometric (Tm-HPDO3A) and selective detection (Eu-DOTAMGly and Tm-HPDO3A) experiments have been proven feasible in vivo.
CONCLUSION: In vitro experiments demonstrated the feasibility of the CEST methodology at 1T for nearly every paraCEST candidate under investigation, except for Eu-HPDO3A. Among the studied compounds, Tm-HPDO3A proved suitable for the application of a ratiometric method for assessing pH both in vitro and in vivo.},
	language = {eng},
	number = {1},
	journal = {Magnetic Resonance in Medicine},
	author = {Rancan, Giaime and Delli Castelli, Daniela and Aime, Silvio},
	month = jan,
	year = {2016},
	pmid = {25651986},
	keywords = {Animals, CEST, Contrast Media, Feasibility Studies, HPDO3A, Heterocyclic Compounds, 1-Ring, Hydrogen-Ion Concentration, Lanthanoid Series Elements, Magnetic Resonance Imaging, Phantoms, Imaging, Rats, Reproducibility of Results, Sensitivity and Specificity, Urinary Bladder, low-field CEST, pH mapping, paraCEST},
	pages = {329--336},
}

@article{ding_assessment_2015,
	title = {Assessment of {In} {Vivo} {Clinical} {Product} {Performance} of a {Weak} {Basic} {Drug} by {Integration} of {In} {Vitro} {Dissolution} {Tests} and {Physiologically} {Based} {Absorption} {Modeling}},
	volume = {17},
	issn = {1550-7416 (Electronic) 1550-7416 (Linking)},
	doi = {10.1208/s12248-015-9797-6},
	abstract = {Effective integration of in vitro tests and absorption modeling can greatly improve our capability in understanding, comparing, and predicting in vivo performances of clinical drug products. In this case, we used a proprietary drug candidate galunisertib to describe the procedures of designing key in vitro tests, analyzing relevant experimental and trial data, and integrating them into physiologically based absorption models to evaluate the performances of its clinical products. By simulating the preclinical study result, we estimated high in vivo permeability for the drug. Given the high sensitivity of its solubility to pH, supersaturation may play an important role in the absorption of galunisertib. Using the dynamic dissolution test, i.e., artificial stomach-duodenum (ASD) model and simulation, we concluded galunisertib in solution or tablet products could maintain supersaturation during the transit in the gastrointestinal tract (GIT). A physiologically based absorption model was established by incorporating these key inputs in the simulation of Trial 1 results of galunisertib solution. To predict the performance of three tablet products, we developed z-factor dissolution models from the multi-pH USP dissolution results and integrate them into the absorption model. The resultant biopharmaceutical models provided good prediction of the extent of absorption of all three products, but underestimated the rate of absorption of one tablet product. Leveraging the ASD result and optimization with the dissolution model, we identified the limitation of the model due to complexity of estimating the dissolution parameter z and its in vitro-in vivo correlation.},
	number = {6},
	journal = {AAPS J},
	author = {Ding, X. and Gueorguieva, I. and Wesley, J. A. and Burns, L. J. and Coutant, C. A.},
	month = nov,
	year = {2015},
	pmcid = {PMC4627443},
	keywords = {*Models, Biological, Administration, Oral, Adult, Animals, Female, Humans, Intestinal Absorption/*drug effects/*physiology, Male, Middle Aged, Permeability, Pyrazoles/*administration \& dosage/*blood, Quinolines/*administration \& dosage/*blood, Rats, Rats, Inbred F344, Solubility, absorption, dissolution, physiologically based model, z-factor},
	pages = {1395--406},
}

@article{jang_rutin_2014,
	title = {Rutin improves functional outcome via reducing the elevated matrix metalloproteinase-9 level in a photothrombotic focal ischemic model of rats},
	volume = {339},
	issn = {1878-5883},
	doi = {10.1016/j.jns.2014.01.024},
	abstract = {BACKGROUND: Blood-brain barrier (BBB) disruption mediated by proteases plays a pivotal role in neural tissue damage after acute ischemic stroke. In an animal stroke model, the activation of matrix metalloproteinases (MMPs), especially MMP-9, was significantly increased and it showed potential association with blood-brain barrier (BBB) disruption and cerebral edema. Theoretically, it is expected that early blockade of expression and activation of MMP-9 after ischemic stroke provides neuroprotective effects from secondary neural tissue damage. This study was aimed to determine the ability of rutin to influence MMP-9 expression, activity and BBB disruption using a photothrombotic focal ischemic model in rats.
METHODS: Adult male Sprague-Dawley rats, weighing between 250 and 300 g (aged 8 weeks) received focal cerebral ischemia by photothrombosis using Rose Bengal (RB) and cold light. Injured animals were divided into two groups; one group received 50mg/kg of rutin intraperitoneally, starting 1h after injury and at 12h intervals for 3 days, while animals in the control group received weight-adjusted doses of saline vehicle over the same period. In each group, the expressions and activities of MMP-9 were assessed by Western blot and gelatin zymography at 6, 24, 48, and 72 h after photothrombotic insult. The effects of rutin on BBB disruption and functional outcomes were also determined.
RESULTS: Western blot and zymographic analysis showed up-regulated MMP-9 expression and activity in the ischemic cortex. The expression and activity of MMP-9 were significantly elevated at 6h after photothrombotic insult, which remained up-regulated for at least until 72 h after injury. In the rutin-treated group, MMP-9 expression and activity were significantly attenuated at 6, 24, and 48 h compared to the control group. Relative to the control group, BBB permeability was significantly reduced in the rutin-treated group. The results of the rotarod test revealed that rutin treatment significantly improved functional outcomes.
CONCLUSIONS: Rutin treatment starting 1h after injury attenuated BBB disruption during photothrombotic focal ischemia, which was partly, at least, achieved through inhibitory effects on MMP-9 expression and activity. The results of this study suggest that rutin might be useful in clinical trials aimed to improve the outcome of patients suffering from acute ischemic stroke.},
	language = {eng},
	number = {1-2},
	journal = {Journal of the Neurological Sciences},
	author = {Jang, Jae-Won and Lee, Jung-Kil and Hur, Hyuk and Kim, Tae-Wan and Joo, Sung-Pil and Piao, Min-Sheng},
	month = apr,
	year = {2014},
	pmid = {24507948},
	note = {00016 },
	keywords = {Animals, Blood-Brain Barrier, Brain Ischemia, Cerebral ischemia, Disease Models, Animal, Enzyme Inhibitors, Funcional outcome, Intracranial Thrombosis, Male, Matrix Metalloproteinase 9, Matrix metalloproteinases, Photic Stimulation, Photothrombosis, Rat, Rats, Rats, Sprague-Dawley, Recovery of Function, Rose Bengal, Rutin, Treatment Outcome},
	pages = {75--80}
}

@article{chiang_vitro_2013,
	title = {In vitro and in vivo evaluation of amorphous solid dispersions generated by different bench-scale processes, using griseofulvin as a model compound},
	volume = {15},
	issn = {1550-7416 (Electronic) 1550-7416 (Linking)},
	doi = {10.1208/s12248-013-9469-3},
	abstract = {Drug polymer-based amorphous solid dispersions (ASD) are widely used in the pharmaceutical industry to improve bioavailability for poorly water-soluble compounds. Spray-drying is the most common process involved in the manufacturing of ASD material. However, spray-drying involves a high investment of material quantity and time. Lower investment manufacturing processes such as fast evaporation and freeze-drying (lyophilization) have been developed to manufacture ASD at the bench level. The general belief is that the overall performance of ASD material is thermodynamically driven and should be independent of the manufacturing process. However, no formal comparison has been made to assess the in vivo performance of material generated by different processes. This study compares the in vitro and in vivo properties of ASD material generated by fast evaporation, lyophilization, and spray-drying methods using griseofulvin as a model compound and hydroxypropyl methylcellulose acetate succinate as the polymer matrix. Our data suggest that despite minor differences in the formulation release properties and stability of the ASD materials, the overall exposure is comparable between the three manufacturing processes under the conditions examined. These results suggest that fast evaporation and lyophilization may be suitable to generate ASD material for oral evaluation. However, caution should be exercised since the general applicability of the present findings will need to be further evaluated.},
	number = {2},
	journal = {AAPS J},
	author = {Chiang, P. C. and Cui, Y. and Ran, Y. and Lubach, J. and Chou, K. J. and Bao, L. and Jia, W. and La, H. and Hau, J. and Sambrone, A. and Qin, A. and Deng, Y. and Wong, H.},
	month = apr,
	year = {2013},
	pmcid = {PMC3675757},
	keywords = {Administration, Oral, Animals, Biological Availability, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Crystallography, X-Ray, Drug Compounding, Drug Stability, Freeze Drying, Griseofulvin/administration \& dosage/*chemistry/pharmacokinetics, Magnetic Resonance Spectroscopy, Male, Methylcellulose/*analogs \& derivatives/chemistry, Powder Diffraction, Rats, Rats, Sprague-Dawley, Solubility, Technology, Pharmaceutical/*methods, Thermogravimetry},
	pages = {608--17},
}

@article{volkova_electrophysiological_2013,
	title = {Electrophysiological correlations of morphological restructuring in experimental local ischemia of different severity in the rat sensorimotor cortex},
	volume = {155},
	issn = {1573-8221},
	abstract = {Local cerebrovascular disorders were modeled by reversible photochemical clotting of hemispheric cortical vessels. Mild ischemia led to reversible edema in the surface layers of the cortex: cytotoxic edema of the neuropile, primarily of the distal dendrites. This status led to an increase in the lower delta rhythm frequency band power. After administration of systemic anesthetic, delta rhythm appeared sooner in the ischemic foci than in intact cortical areas. More severe ischemia led to the appearance of dark and pyknotic neurons and reduction of oscillation power in all EEG spectrum bands. Restructuring of primarily dendrites caused by local moderate ischemia of the surface cortical layers at the early stage of neurodegenerative processes stimulated the inhibitory recovery processes.},
	language = {eng},
	number = {2},
	journal = {Bulletin of Experimental Biology and Medicine},
	author = {Volkova, D. A. and Kositzyn, N. S. and Goloborodko, E. V. and Loginova, N. A. and Svinov, M. M.},
	month = jun,
	year = {2013},
	pmid = {24131005},
	note = {00000 },
	keywords = {Anesthetics, Animals, Brain, Cerebral Cortex, Cerebral Infarction, Delta Rhythm, Dendrites, Electroencephalography, Hypoxia-Ischemia, Brain, Male, Neuropil, Rats, Rats, Wistar, Rose Bengal},
	pages = {264--267}
}

Paper  doi  abstract   bibtex   

@article{Jones2013,
	title = {Different {Calcium} {Sources} {Control} {Somatic} versus {Dendritic} {SK} {Channel} {Activation} during {Action} {Potentials}},
	volume = {33},
	issn = {0270-6474},
	url = {http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2073-13.2013},
	doi = {10.1523/JNEUROSCI.2073-13.2013},
	abstract = {Small-conductance calcium-activated potassium (SK) channels play an important role in regulating neuronal excitability. While SK channels at the soma have long been known to contribute to the medium afterhyperpolarization (mAHP), recent evidence indicates they also regulate NMDA receptor activation in dendritic spines. Here we investigate the activation of SK channels in spines and dendrites of rat cortical pyramidal neurons during action potentials (APs), and compare this to SK channel activation at the soma. Using confocal calcium imaging, we demonstrate that the inhibition of SK channels with apamin results in a location-dependent increase in calcium influx into dendrites and spines during backpropagating APs (average increase, {\textasciitilde}40\%). This effect was occluded by block of R-type voltage-dependent calcium channels (VDCCs), but not by inhibition of N- or P/Q-type VDCCs, or block of calcium release from intracellular stores. During these experiments, we noticed that the calcium indicator (Oregon Green BAPTA-1) blocked the mAHP. Subsequent experiments using low concentrations of EGTA (1 mm) produced the same result, suggesting that somatic SK channels are not tightly colocalized with their calcium source. Consistent with this idea, all known subtypes of VDCCs except R-type were calcium sources for the apamin-sensitive mAHP at the soma. We conclude that SK channels in spines and dendrites of cortical pyramidal neurons regulate calcium influx during backpropagating APs in a distance-dependent manner, and are tightly coupled to R-type VDCCs. In contrast, SK channels activated by APs at the soma of these neurons are weakly coupled to a variety of VDCCs.},
	number = {50},
	urldate = {2013-12-12},
	journal = {Journal of Neuroscience},
	author = {Jones, Scott L. and Stuart, Greg J.},
	month = dec,
	year = {2013},
	pmid = {24336706},
	note = {Number: 50},
	keywords = {Action Potentials, Action Potentials: physiology, Animals, Calcium, Calcium Channels, Calcium: metabolism, Cerebral Cortex, Cerebral Cortex: cytology, Cerebral Cortex: drug effects, Cerebral Cortex: physiology, Dendrites, Dendrites: drug effects, Dendrites: physiology, Egtazic Acid, Egtazic Acid: pharmacology, Organic Chemicals, Organic Chemicals: pharmacology, Pyramidal Cells, Pyramidal Cells: cytology, Pyramidal Cells: drug effects, Pyramidal Cells: physiology, R-Type, R-Type: physiology, Rats, Small-Conductance Calcium-Activated Potassium Chan},
	pages = {19396--19405},
}

Paper  doi  abstract   bibtex   

@article{Arthuis2013,
abstract = {OBJECTIVE: To monitor and quantify uteroplacental perfusion in rat pregnancies by Doppler ultrasound (DUS) and contrast-enhanced ultrasound (CEUS).

METHODS: Fourteen rats were randomized in two groups (the CEUS group and the control group). On days 8, 11, 14, 17, 19 and 20 of gestation, we used DUS to measure the resistance index (RI), pulsatility index and blood velocity in the uterine, arcuate and umbilical arteries in both groups. On days 14, 17 and 20, one group was also examined by CEUS. Quantitative perfusion parameters were calculated in 4 compartments (mesometrial triangle, placenta, umbilical cord and fetus) and compared.

RESULTS: The DUS measurement showed that the RI of the uterine and arcuate arteries decreased (p < 0.01) from day 14 to day 17, while velocity increased each of these arteries (p < 0.01 and p < 0.05, respectively). Quantification of uteroplacental perfusion by CEUS in bolus mode revealed that blood volume and local blood flow increased from day 14 to day 20 in the mesometrial triangle (p < 0.01) and the placenta (p < 0.05). In the CEUS destruction-replenishment mode, the perfusion parameters showed trends similar to those observed in bolus mode. No microbubbles were detected in the umbilical vein or fetal compartments. The weights of pups in the two groups did not differ significantly.

CONCLUSIONS: CEUS estimates of placental perfusion complement the data provided by DUS.},
author = {Arthuis, C J and Novell, Anthony and Escoffre, Jean-Michel and Patat, Fr\'{e}d\'{e}ric and Bouakaz, Ayache and Perrotin, F},
doi = {10.1016/j.placenta.2013.01.019},
file = {:C$\backslash$:/Users/emnicolas/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Arthuis et al. - 2013 - New insights into uteroplacental perfusion quantitative analysis using Doppler and contrast-enhanced ultrasound.pdf:pdf},
issn = {1532-3102},
journal = {Placenta},
keywords = {Animals,Blood Flow Velocity,Contrast Media,Female,Gestational Age,Microbubbles,Placenta,Placenta: blood supply,Pregnancy,Pulsatile Flow,Rats,Rats, Sprague-Dawley,Ultrasonography,Ultrasonography, Doppler,Ultrasonography, Prenatal,Ultrasonography: methods,Umbilical Arteries,Uterine Artery,Uterine Artery: ultrasonography,Uterus,Uterus: blood supply,Vascular Resistance},
month = may,
number = {5},
pages = {424--31},
pmid = {23518453},
publisher = {Elsevier Ltd},
title = {{New insights into uteroplacental perfusion: quantitative analysis using Doppler and contrast-enhanced ultrasound imaging.}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/23518453},
volume = {34},
year = {2013}
}

Paper  Website  abstract   bibtex   

@article{
 title = {MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3.},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 keywords = {biophysics,cell biology},
 pages = {4765-4782},
 volume = {41},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3643581&tool=pmcentrez&rendertype=abstract},
 month = {5},
 id = {927991cb-de76-37b6-acde-cfb915a7fa69},
 created = {2016-04-27T11:42:56.000Z},
 file_attached = {true},
 profile_id = {9b1c14de-b75a-3e23-a406-ef006d6fed26},
 last_modified = {2017-03-25T02:42:51.878Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {Gooding2013},
 source_type = {article},
 folder_uuids = {6e034f54-5623-437a-811f-80d304e37fd9},
 abstract = {Exon 3 of the rat $α$-tropomyosin (Tpm1) gene is repressed in smooth muscle cells, allowing inclusion of the mutually exclusive partner exon 2. Two key types of elements affect repression of exon 3 splicing: binding sites for polypyrimidine tract-binding protein (PTB) and additional negative regulatory elements consisting of clusters of UGC or CUG motifs. Here, we show that the UGC clusters are bound by muscleblind-like proteins (MBNL), which act as repressors of Tpm1 exon 3. We show that the N-terminal region of MBNL1, containing its four CCCH zinc-finger domains, is sufficient to mediate repression. The same region of MBNL1 can make a direct protein-to-protein interaction with PTB, and RNA binding by MBNL promotes this interaction, apparently by inducing a conformational change in MBNL. Moreover, single molecule analysis showed that MBNL-binding sites increase the binding of PTB to its own sites. Our data suggest that the smooth muscle splicing of Tpm1 is mediated by allosteric assembly of an RNA-protein complex minimally comprising PTB, MBNL and their cognate RNA-binding sites.},
 bibtype = {article},
 author = {Gooding, Clare and Edge, Christopher and Lorenz, Mike and Coelho, Miguel B and Winters, Mikael and Kaminski, Clemens F and Cherny, Dmitry and Eperon, Ian C and Smith, Christopher W J},
 journal = {Nucleic acids research},
 number = {9}
}

Paper  abstract   bibtex   

@article{
 id = {c833f827-d0f9-33bf-86c2-b8903285f617},
 title = {Structural features of aquaporin 4 supporting the formation of arrays and junctions in biomembranes.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Animals,Aquaporin 4,Aquaporin 4: chemistry,Biophysics,Biophysics: methods,Cattle,Cell Membrane,Cell Membrane: metabolism,Lipids,Lipids: chemistry,Models, Molecular,Molecular Conformation,Molecular Dynamics Simulation,Protein Binding,Protein Interaction Mapping,Protein Interaction Mapping: methods,Protein Structure, Tertiary,Proteins,Proteins: chemistry,Rats,Thermodynamics,Water,Water: chemistry},
 created = {2014-12-10T04:09:01.000Z},
 pages = {2234-43},
 volume = {1818},
 websites = {http://www.sciencedirect.com/science/article/pii/S0005273612001319},
 month = {9},
 accessed = {2014-06-23},
 file_attached = {true},
 profile_id = {6708b05a-e661-38c6-9bb8-cf4f304b6385},
 group_id = {424eb3e1-9b50-35ed-91d3-65c78c3164d7},
 last_modified = {2014-12-10T09:11:31.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Hofinger2012a},
 abstract = {A limited class of aquaporins has been described to form regular arrays and junctions in membranes. The biological significance of these structures, however, remains uncertain. Here we analyze the underlying physical principles with the help of a computational procedure that takes into account protein-protein as well as protein-membrane interactions. Experimentally observed array/junction structures are systematically (dis)assembled and major driving forces identified. Aquaporin 4 was found to be markedly different from the non-junction forming aquaporin 1. The environmental stabilization resulting from embedding into the biomembrane was identified as the main driving force. This highlights the role of protein-membrane interactions in aquaporin 4. Analysis of the type presented here can help to decipher the biological role of membrane arrays and junctions formed by aquaporin.},
 bibtype = {article},
 author = {Höfinger, Siegfried and Yamamoto, Eiji and Hirano, Yoshinori and Zerbetto, Francesco and Narumi, Tetsu and Yasuoka, Kenji and Yasui, Masato},
 journal = {Biochim. Biophys. Acta},
 number = {9}
}

Paper  doi  abstract   bibtex   

@article{Goutman2012,
	title = {Transmitter release from cochlear hair cells is phase locked to cyclic stimuli of different intensities and frequencies.},
	volume = {32},
	issn = {1529-2401},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3705563&tool=pmcentrez&rendertype=abstract},
	doi = {10.1523/JNEUROSCI.0457-12.2012},
	abstract = {The auditory system processes time and intensity through separate brainstem pathways to derive spatial location as well as other salient features of sound. The independent coding of time and intensity begins in the cochlea, where afferent neurons can fire action potentials at constant phase throughout a wide range of stimulus intensities. We have investigated time and intensity coding by simultaneous presynaptic and postsynaptic recording at the hair cell-afferent synapse from rats. Trains of depolarizing steps to the hair cell were used to elicit postsynaptic currents that occurred at constant phase for a range of membrane potentials over which release probability varied significantly. To probe the underlying mechanisms, release was examined using single steps to various command voltages. As expected for vesicular release, first synaptic events occurred earlier as presynaptic calcium influx grew larger. However, synaptic depression produced smaller responses with longer first latencies. Thus, during repetitive hair cell stimulation, as the hair cell is more strongly depolarized, increased calcium channel gating hurries transmitter release, but the resulting vesicular depletion produces a compensatory slowing. Quantitative simulation of ribbon function shows that these two factors varied reciprocally with hair cell depolarization (stimulus intensity) to produce constant synaptic phase. Finally, we propose that the observed rapid vesicle replenishment would help maintain the vesicle pool, which in turn would equilibrate with the stimulus intensity (and therefore the number of open Ca(2+) channels), so that for trains of different levels the average phase will be conserved.},
	number = {47},
	journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
	author = {Goutman, Juan D},
	year = {2012},
	pmid = {23175853},
	note = {Number: 47
ISBN: 1529-2401 (Electronic){\textbackslash}r0270-6474 (Linking)},
	keywords = {Acoustic Stimulation, Analysis of Variance, Animals, Calcium Channels, Calcium Channels: metabolism, Calcium Signaling, Calcium Signaling: physiology, Cochlea, Cochlea: cytology, Cochlea: metabolism, Excitatory Postsynaptic Potentials, Excitatory Postsynaptic Potentials: physiology, Female, Hair Cells, Auditory, Inner, Hair Cells, Auditory, Inner: metabolism, Ion Channel Gating, Ion Channel Gating: physiology, Kinetics, Male, Membrane Potentials, Membrane Potentials: physiology, Neurons, Afferent, Neurons, Afferent: metabolism, Neurotransmitter Agents, Neurotransmitter Agents: metabolism, Presynaptic Terminals, Presynaptic Terminals: metabolism, Rats, Rats, Sprague-Dawley, Synaptic Vesicles, Synaptic Vesicles: metabolism, Synaptic Vesicles: physiology},
	pages = {17025--35a},
}

Website  abstract   bibtex   

@article{
 title = {Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity},
 type = {article},
 year = {2011},
 identifiers = {[object Object]},
 keywords = {Analysis of Variance,Animals,Astrocytes,Astrocytes: drug effects,Astrocytes: metabolism,Blotting,Brain,Brain: drug effects,Brain: metabolism,Cell Survival,Cell Survival: drug effects,Cells,Cultured,Glutathione,Glutathione: metabolism,Heme Oxygenase-1,Heme Oxygenase-1: genetics,Heme Oxygenase-1: metabolism,Immunohistochemistry,Messenger,Messenger: genetics,Messenger: metabolism,Methylmercury Compounds,Methylmercury Compounds: metabolism,Methylmercury Compounds: pharmacology,Microglia,Microglia: drug effects,Microglia: metabolism,NF-E2-Related Factor 2,NF-E2-Related Factor 2: genetics,NF-E2-Related Factor 2: metabolism,Newborn,Oxidative Stress,Oxidative Stress: drug effects,RNA,Rats,Reactive Oxygen Species,Reactive Oxygen Species: metabolism,Small Interfering,Sprague-Dawley,Western},
 pages = {810-820},
 volume = {59},
 websites = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3080116&tool=pmcentrez&rendertype=abstract},
 month = {5},
 id = {96d57e03-080d-328b-9894-60a295f16b47},
 created = {2012-02-06T18:35:34.000Z},
 accessed = {2012-01-30},
 file_attached = {true},
 profile_id = {1f6a330f-f6a3-36e6-abae-0954f070a071},
 group_id = {3addd0f7-d578-34d3-be80-24022cc062a1},
 last_modified = {2017-03-14T12:29:49.371Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Ni2011},
 folder_uuids = {ef0eef76-72e0-41f4-97ad-0a486454f68c,ed1ada3f-9f8b-434b-9c9d-6416858928c5},
 private_publication = {false},
 abstract = {As the two major glial cell types in the brain, astrocytes and microglia play pivotal but different roles in maintaining optimal brain function. Although both cell types have been implicated as major targets of methylmercury (MeHg), their sensitivities and adaptive responses to this metal can vary given their distinctive properties and physiological functions. This study was carried out to compare the responses of astrocytes and microglia following MeHg treatment, specifically addressing the effects of MeHg on cell viability, reactive oxygen species (ROS) generation and glutathione (GSH) levels, as well as mercury (Hg) uptake and the expression of NF-E2-related factor 2 (Nrf2). Results showed that microglia are more sensitive to MeHg than astrocytes, a finding that is consistent with their higher Hg uptake and lower basal GSH levels. Microglia also demonstrated higher ROS generation compared with astrocytes. Nrf2 and its downstream genes were upregulated in both cell types, but with different kinetics (much faster in microglia). In summary, microglia and astrocytes each exhibit a distinct sensitivity to MeHg, resulting in their differential temporal adaptive responses. These unique sensitivities appear to be dependent on the cellular thiol status of the particular cell type.},
 bibtype = {article},
 author = {Ni, Mingwei and Li, Xin and Yin, Zhaobao and Sidoryk-Węgrzynowicz, Marta and Jiang, Haiyan and Farina, Marcelo and Rocha, Joao B. T. and Syversen, Tore and Aschner, Michael},
 journal = {GLIA},
 number = {5}
}

Paper  doi  abstract   bibtex   

@article{kim_para-_2011,
	title = {Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity.},
	volume = {119},
	issn = {1552-9924},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3080935&tool=pmcentrez&rendertype=abstract},
	doi = {10.1289/ehp.1002728},
	abstract = {Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+))signaling; however, specific mechanisms have yet to be defined.},
	number = {4},
	journal = {Environmental health perspectives},
	author = {Kim, Kyung Ho and Bose, Diptiman D and Ghogha, Atefeh and Riehl, Joyce and Zhang, Rui and Barnhart, Christopher D and Lein, Pamela J and Pessah, Isaac N},
	month = apr,
	year = {2011},
	pmid = {21106467},
	keywords = {Animals, Calcium, Calcium Signaling, Calcium Signaling: drug effects, Calcium: metabolism, Environmental Pollutants, Environmental Pollutants: chemistry, Environmental Pollutants: metabolism, Environmental Pollutants: toxicity, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: chemistry, Halogenated Diphenyl Ethers: metabolism, Halogenated Diphenyl Ethers: toxicity, Humans, Nervous System, Nervous System: drug effects, Nervous System: metabolism, Rats, Ryanodine Receptor Calcium Release Channel, Ryanodine Receptor Calcium Release Channel: metabo, Sprague-Dawley, Structure-Activity Relationship, cell line},
	pages = {519--26},
}

Paper  doi  abstract   bibtex   

@article{bondy_brominated_2011,
	title = {Brominated diphenyl ether ({BDE}) levels in liver, adipose, and milk from adult and juvenile rats exposed by gavage to the {DE}-71 technical mixture.},
	volume = {26},
	issn = {1522-7278},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/20549633},
	doi = {10.1002/tox.20603},
	abstract = {Brominated diphenyl ethers (BDEs) are used as flame retardants in consumer products. Rodent studies indicate that the liver, thyroid, and nervous system of developing animals are targets of BDEs. To explore the relationship between exposure and health in developing animals, BDE accumulation in adult and juvenile rats was examined in conjunction with changes in liver weight and serum thyroxine (T4). Adult (F0) rats received the commercial BDE mixture DE-71 by gavage at doses of 0.5, 5, and 25 mg kg(-1) body weight (bw)/day for 21 weeks. F0 rats were mated and exposure continued throughout breeding, pregnancy, lactation, and postweaning until the pups (F1 generation) reached postnatal day (PND) 42. Milk was collected from lactating dams. Adipose and liver samples were collected from F0 and F1 males and females for BDE congener analysis. Congener prevalence in rat tissues mimicked congener prevalence in wildlife and humans. Tissue concentrations of all congeners except BDE-153 were lower than would be expected based on dose proportionality, confirming that BDE-153 has a high capacity for bioaccumulation. BDEs were transferred from maternal tissues to milk during lactation. Milk congener profiles differed from maternal tissue profiles indicating that degree of bromination and maternal sequestration influenced BDE transfer to milk. Female F1 rats accumulated more BDEs than F1 males, indicating that female rats were less able to metabolize and/or excrete BDEs. Significant effects on liver weight and serum T4 levels were observed in adults and juveniles in the middle and high dose groups, corresponding to BDE levels in the μg g(-1) range. Although it remains to be determined how human liver and thyroid are affected by exposure to much lower BDE levels, the present study confirmed that gender and reproductive status influence BDE accumulation in tissues and BDE transfer to the neonate via milk.},
	number = {6},
	journal = {Environmental toxicology},
	author = {Bondy, G S and Gaertner, D and Cherry, W and MacLellan, E and Coady, L and Arnold, D L and Doucet, J and Rowsell, P R},
	month = nov,
	year = {2011},
	pmid = {20549633},
	keywords = {Adipose Tissue, Adipose Tissue: metabolism, Animals, Female, Flame Retardants: metabolism, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: metabolism, Halogenated Diphenyl Ethers: toxicity, Liver, Liver: metabolism, Male, Milk, Milk: metabolism, Polybrominated Biphenyls, Polybrominated Biphenyls: metabolism, Pregnancy, Pregnancy Complications, Rats, Sprague-Dawley, Thyroid Gland, Thyroid Gland: metabolism},
	pages = {677--90},
}

Paper  doi  abstract   bibtex   

@article{taliaz_resilience_2011,
	title = {Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor.},
	volume = {31},
	issn = {1529-2401},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21430148},
	doi = {10.1523/JNEUROSCI.5725-10.2011},
	abstract = {Chronic stress is a trigger for several psychiatric disorders, including depression; however, critical individual differences in resilience to both the behavioral and the neurochemical effects of stress have been reported. A prominent mechanism by which the brain reacts to acute and chronic stress is activation of the hypothalamic-pituitary-adrenal (HPA) axis, which is inhibited by the hippocampus via a polysynaptic circuit. Alterations in secretion of stress hormones and levels of brain-derived neurotrophic factor (BDNF) in the hippocampus were implicated in depression and the effects of antidepressant medications. However, the potential role of hippocampal BDNF in behavioral resilience to chronic stress and in the regulation of the HPA axis has not been evaluated. In the present study, Sprague Dawley rats were subjected to 4 weeks of chronic mild stress (CMS) to induce depressive-like behaviors after lentiviral vectors were used to induce localized BDNF overexpression or knockdown in the hippocampus. The behavioral outcome was measured during 3 weeks after the CMS procedure, then plasma samples were taken for measurements of corticosterone levels, and finally hippocampal tissue was taken for BDNF measurements. We found that hippocampal BDNF expression plays a critical role in resilience to chronic stress and that reduction of hippocampal BDNF expression in young, but not adult, rats induces prolonged elevations in corticosterone secretion. The present study describes a mechanism for individual differences in responses to chronic stress and implicates hippocampal BDNF in the development of neural circuits that control adequate stress adaptations.},
	number = {12},
	urldate = {2012-03-11},
	journal = {Journal of Neuroscience},
	author = {Taliaz, Dekel and Loya, Assaf and Gersner, Roman and Haramati, Sharon and Chen, Alon and Zangen, Abraham},
	month = mar,
	year = {2011},
	pmid = {21430148},
	keywords = {Aging, Aging: metabolism, Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: genetics, Brain-Derived Neurotrophic Factor: physiology, Chronic Disease, Corticosterone, Corticosterone: blood, Environment, Enzyme-Linked Immunosorbent Assay, Exploratory Behavior, Exploratory Behavior: physiology, Gene Knockdown Techniques, Hippocampus, Hippocampus: metabolism, Hippocampus: physiology, Hydrocortisone, Hydrocortisone: metabolism, Hypothalamo-Hypophyseal System, Hypothalamo-Hypophyseal System: physiology, Locomotion, Locomotion: physiology, Male, Microinjections, Molecular Sequence Data, Pituitary-Adrenal System, Pituitary-Adrenal System: physiology, Psychological, Psychological: psychology, Rats, Resilience, Reverse Transcriptase Polymerase Chain Reaction, Sprague-Dawley, Stress, Swimming, Swimming: psychology},
	pages = {4475--83},
}

Paper  doi  abstract   bibtex   

@article{ibhazehiebo_disruption_2011,
	title = {Disruption of thyroid hormone receptor-mediated transcription and thyroid hormone-induced {Purkinje} cell dendrite arborization by polybrominated diphenyl ethers.},
	volume = {119},
	issn = {1552-9924},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3040602&tool=pmcentrez&rendertype=abstract},
	doi = {10.1289/ehp.1002065},
	abstract = {Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants and are becoming a ubiquitous environmental contaminant. Adverse effects in the developing brain are of great health concern.},
	number = {2},
	journal = {Environmental health perspectives},
	author = {Ibhazehiebo, Kingsley and Iwasaki, Toshiharu and Kimura-Kuroda, Junko and Miyazaki, Wataru and Shimokawa, Noriaki and Koibuchi, Noriyuki},
	month = feb,
	year = {2011},
	pmid = {20870570},
	keywords = {Animals, Cells, Cultured, Female, Flame retardants, Genetic, Genetic: drug effects, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: pharmacology, Haplorhini, Immunohistochemistry, Pregnancy, Purkinje Cells, Purkinje Cells: drug effects, Purkinje Cells: metabolism, Rats, Receptors, Thyroid Hormone, Thyroid Hormone: genetics, Thyroid Hormone: metabolism, Thyroid Hormones, Thyroid Hormones: pharmacology, Transcription, Wistar, cell line},
	pages = {168--75},
}

@article{ dufour-rainfray_behavior_2010,
  title = {Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism},
  volume = {470},
  issn = {1872-7972},
  shorttitle = {Behavior and serotonergic disorders in rats exposed prenatally to valproate},
  doi = {10.1016/j.neulet.2009.12.054},
  abstract = {In order to explore whether some aspects of the autistic phenotype could be related to impairment of the serotonergic system, we chose an animal model which mimics a potential cause of autism, i.e. rats exposed to valproate ({VPA}) on the 9th embryonic day (E9). Previous studies have suggested that {VPA} exposure in rats at E9 caused a dramatic shift in the distribution of serotonergic neurons on postnatal day 50 ({PND}50). Behavioral studies have also been performed but on rats that were exposed to {VPA} later (E12.5). Our aim was to test whether {VPA} exposure at E9 induces comparable behavioral impairments than at E12.5 and causes serotonergic impairments which could be related to behavioral modifications. The results showed significant behavioral impairments such as a lower tendency to initiate social interactions and hyperlocomotor activity in juvenile male rats. The serotonin levels of these animals at {PND}50 were decreased (-46%) in the hippocampus, a structure involved in social behavior. This study suggests that {VPA} could have a direct or indirect action on the serotonergic system as early as the progenitor cell stage. Early embryonic exposure to {VPA} in rats provides a good model for several specific aspects of autism and should help to continue to explore pathophysiological hypotheses.},
  language = {eng},
  number = {1},
  journal = {Neuroscience Letters},
  author = {Dufour-Rainfray, Diane and Vourc'h, Patrick and Le Guisquet, Anne-Marie and Garreau, Lucette and Ternant, David and Bodard, Sylvie and Jaumain, Emilie and Gulhan, Zuhal and Belzung, Catherine and Andres, Christian R. and Chalon, Sylvie and Guilloteau, Denis},
  month = {February},
  year = {2010},
  pmid = {20036713},
  keywords = {Animals, Autistic Disorder, Behavior, Animal, Brain, Disease Models, Animal, Female, {GABA} Agents, Hippocampus, Hydroxyindoleacetic Acid, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, {RNA}-Binding Proteins, Rats, Rats, Wistar, Serotonin, Social Behavior, Time Factors, Valproic Acid},
  pages = {55--59}
}

Paper  doi  abstract   bibtex   

@article{Piatkevich2010,
	title = {Monomeric red fluorescent proteins with a large {Stokes} shift.},
	volume = {107},
	issn = {1091-6490},
	url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2851791&tool=pmcentrez&rendertype=abstract},
	doi = {10.1073/pnas.0914365107},
	abstract = {Two-photon microscopy has advanced fluorescence imaging of cellular processes in living animals. Fluorescent proteins in the blue-green wavelength range are widely used in two-photon microscopy; however, the use of red fluorescent proteins is limited by the low power output of Ti-Sapphire lasers above 1,000 nm. To overcome this limitation we have developed two red fluorescent proteins, LSS-mKate1 and LSS-mKate2, which possess large Stokes shifts with excitation/emission maxima at 463/624 and 460/605 nm, respectively. These LSS-mKates are characterized by high pH stability, photostability, rapid chromophore maturation, and monomeric behavior. They lack absorbance in the green region, providing an additional red color to the commonly used red fluorescent proteins. Substantial overlap between the two-photon excitation spectra of the LSS-mKates and blue-green fluorophores enables multicolor imaging using a single laser. We applied this approach to a mouse xenograft model of breast cancer to intravitally study the motility and Golgi-nucleus alignment of tumor cells as a function of their distance from blood vessels. Our data indicate that within 40 mum the breast cancer cells show significant polarization towards vessels in living mice.},
	number = {12},
	urldate = {2013-08-09},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	author = {Piatkevich, Kiryl D and Hulit, James and Subach, Oksana M and Wu, Bin and Abdulla, Arian and Segall, Jeffrey E and Verkhusha, Vladislav V},
	month = mar,
	year = {2010},
	pmid = {20212155},
	keywords = {\#nosource, Amino Acid Substitution, Animals, Cell Line, Tumor, Cell Nucleus, Cell Nucleus: metabolism, Female, Golgi Apparatus, Golgi Apparatus: metabolism, HeLa Cells, Humans, Luminescent Proteins, Luminescent Proteins: chemistry, Luminescent Proteins: genetics, Luminescent Proteins: metabolism, Mammary Neoplasms, Experimental, Mammary Neoplasms, Experimental: blood supply, Mammary Neoplasms, Experimental: genetics, Mammary Neoplasms, Experimental: metabolism, Mice, Microscopy, Fluorescence, Multiphoton, Mutagenesis, Neoplasm Transplantation, Photochemical Processes, Rats, Recombinant Fusion Proteins, Recombinant Fusion Proteins: chemistry, Recombinant Fusion Proteins: genetics, Recombinant Fusion Proteins: metabolism, Transplantation, Heterologous},
	pages = {5369--74},
}

Paper  doi  abstract   bibtex   

@article{dingemans_hexabromocyclododecane_2009,
	title = {Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in {PC12} cells.},
	volume = {107},
	issn = {1096-0929},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19056936},
	doi = {10.1093/toxsci/kfn249},
	abstract = {Environmental levels of the brominated flame retardant (BFR) hexabromocyclododecane (HBCD) have been increasing. HBCD has been shown to cause adverse effects on learning and behavior in mice, as well as on dopamine uptake in rat synaptosomes and synaptic vesicles. For other BFRs, alterations in the intracellular Ca(2+) homeostasis have been observed. Therefore, the aim of this study was to investigate whether the technical HBCD mixture and individual stereoisomers affect the intracellular Ca(2+) concentration ([Ca(2+)](i)) in a neuroendocrine in vitro model (PC12 cells). [Ca(2+)](i) and vesicular catecholamine release were measured using respectively single-cell Fura-2 imaging and amperometry. Exposure of PC12 cells to the technical HBCD mixture or individual stereoisomers did neither affect basal [Ca(2+)](i), nor the frequency of basal neurotransmitter release. However, exposure to HBCD (0-20 microM) did cause a dose-dependent reduction of a subsequent depolarization-evoked increase in [Ca(2+)](i). This effect was apparent only when HBCD was applied at least 5 min before depolarization (maximum effect after 20 min exposure). The effects of alpha- and beta-HBCD were comparable to that of the technical mixture, whereas the inhibitory effect of gamma-HBCD was larger. Using specific blockers of L-, N- or P/Q-type voltage-gated Ca(2+) channels (VGCCs) it was shown that the inhibitory effect of HBCD is not VGCC-specific. Additionally, the number of cells showing depolarization-evoked neurotransmitter release was markedly reduced following HBCD exposure. Summarizing, HBCD inhibits depolarization-evoked [Ca(2+)](i) and neurotransmitter release. As increasing HBCD levels should be anticipated, these findings justify additional efforts to establish an adequate exposure, hazard and risk assessment.},
	number = {2},
	journal = {Toxicological sciences},
	author = {Dingemans, Milou M L and Heusinkveld, Harm J and de Groot, Aart and Bergman, Ake and van Den Berg, Martin and Westerink, Remco H S},
	month = feb,
	year = {2009},
	pmid = {19056936},
	keywords = {Animals, Brominated, Brominated: toxicity, Calcium, Calcium Channel Blockers, Calcium Channel Blockers: pharmacology, Calcium: metabolism, Catecholamines, Catecholamines: metabolism, Cell Polarity, Cell Polarity: drug effects, Cell Polarity: physiology, Cell Survival, Cell Survival: drug effects, Cytoplasmic Vesicles, Cytoplasmic Vesicles: drug effects, Cytoplasmic Vesicles: metabolism, Cytosol, Cytosol: drug effects, Cytosol: metabolism, Data Interpretation, Dose-Response Relationship, Drug, Electrophysiology, Flame Retardants: toxicity, Flame retardants, Fluorescent Dyes, Fura-2, Hydrocarbons, Neurotransmitter Agents, Neurotransmitter Agents: metabolism, PC12 Cells, Rats, Statistical, Stereoisomerism, frbldg, tox},
	pages = {490--7},
}

Paper  doi  abstract   bibtex   

@article{Degerman2009,
	title = {An automatic system for in vitro cell migration studies.},
	volume = {233},
	issn = {1365-2818},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19196424},
	doi = {10.1111/j.1365-2818.2008.03108.x},
	abstract = {This paper describes a system for in vitro cell migration analysis. Adult neural stem/progenitor cells are studied using time-lapse bright-field microscopy and thereafter stained immunohistochemically to find and distinguish undifferentiated glial progenitor cells and cells having differentiated into type-1 or type-2 astrocytes. The cells are automatically segmented and tracked through the time-lapse sequence. An extension to the Chan-Vese Level Set segmentation algorithm, including two new terms for specialized growing and pruning, made it possible to resolve clustered cells, and reduced the tracking error by 65\%. We used a custom-built manual correction module to form a ground truth used as a reference for tracked cells that could be identified from the fluorescence staining. On average, the tracks were correct 95\% of the time, using our new segmentation. The tracking, or association of segmented cells, was performed using a 2-state Hidden Markov Model describing the random behaviour of the cells. By re-estimating the motion model to conform with the segmented data we managed to reduce the number of tracking parameters to essentially only one. Upon characterization of the cell migration by the HMM state occupation function, it was found that glial progenitor cells were moving randomly 2/3 of the time, while the type-2 astrocytes showed a directed movement 2/3 of the time. This finding indicates possibilities for cell-type specific identification and cell sorting of live cells based on specific movement patterns in individual cell populations, which would have valuable applications in neurobiological research.},
	number = {1},
	urldate = {2013-09-06},
	journal = {Journal of microscopy},
	author = {Degerman, J and Thorlin, T and Faijerson, J and Althoff, K and Eriksson, P S and Put, R V D and Gustavsson, T},
	month = jan,
	year = {2009},
	pmid = {19196424},
	keywords = {\#nosource, Animals, Cell Movement, Cells, Cultured, Microscopy, Video, Microscopy, Video: methods, Rats, Stem Cells, Stem Cells: physiology},
	pages = {178--91},
}

Paper  doi  bibtex   

@article{Tang2009,
	title = {Faithful expression of multiple proteins via {2A}-peptide self-processing: a versatile and reliable method for manipulating brain circuits.},
	volume = {29},
	issn = {1529-2401},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/19587267},
	doi = {10.1523/JNEUROSCI.0359-09.2009},
	number = {27},
	urldate = {2013-08-09},
	journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
	author = {Tang, Wannan and Ehrlich, Ingrid and Wolff, Steffen B E and Michalski, Ann-Marie and Wölfl, Stefan and Hasan, Mazahir T and Lüthi, Andreas and Sprengel, Rolf},
	month = jul,
	year = {2009},
	pmid = {19587267},
	keywords = {\#nosource, Amino Acid Sequence, Animals, Archaeal Proteins, Archaeal Proteins: biosynthesis, Archaeal Proteins: genetics, Archaeal Proteins: metabolism, Cell Line, Cells, Cultured, Cytomegalovirus, Cytomegalovirus: chemistry, Cytomegalovirus: genetics, Dependovirus, Dependovirus: chemistry, Dependovirus: genetics, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Bacterial: physiology, Gene Expression Regulation, Viral, Gene Expression Regulation, Viral: physiology, Hippocampus, Hippocampus: metabolism, Hippocampus: microbiology, Hippocampus: physiology, Hippocampus: virology, Humans, Mice, Molecular Sequence Data, Nerve Net, Nerve Net: metabolism, Nerve Net: microbiology, Nerve Net: physiology, Nerve Net: virology, Nerve Tissue Proteins, Nerve Tissue Proteins: biosynthesis, Nerve Tissue Proteins: genetics, Nerve Tissue Proteins: metabolism, Neurons, Neurons: metabolism, Neurons: microbiology, Neurons: virology, Protein Processing, Post-Translational, Protein Processing, Post-Translational: genetics, Rats, Viral Proteins, Viral Proteins: biosynthesis, Viral Proteins: genetics, Viral Proteins: metabolism},
	pages = {8621--9},
}

Paper  doi  abstract   bibtex   

@article{goldbaum_expression_2008,
	title = {The expression of tubulin polymerization promoting protein {TPPP}/p25α is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress},
	volume = {56},
	copyright = {Copyright © 2008 Wiley‐Liss, Inc.},
	issn = {1098-1136},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.20720},
	doi = {10.1002/glia.20720},
	abstract = {The tubulin polymerization-promoting protein (TPPP)/p25α was identified as a brain specific protein, is associated with microtubules (MTs) in vitro and can promote abnormal MT assembly. Furthermore it has aggregation promoting properties and is a constituent in pathological protein deposits of neurodegenerative diseases. In the brain, TPPP/p25α is present in myelinating oligodendrocytes. Here we show, using cultured rat brain oligodendrocytes, that TPPP/p25α expression is increasing during development in culture, and particularly in immature cells is associated with the centrosome. MT binding properties in oligodendrocytes are rather low, however, when MTs are disassembled by nocodazole, TPPP/p25α accumulates in the perinuclear region. Treatment of oligodendrocytes with the proteasomal inhibitor MG-132 (1 μM; 18 h) caused an increase in the amount of TPPP/p25α by about 40\%, a decrease in its solubility, and led to the appearance of TPPP/p25α-positive cytoplasmic inclusions, which stained with thioflavin S and resembled inclusion bodies. Hence, it might be speculated that acute or chronic malfunction of the proteasomal degradation system, leading to the accumulation of aggregation prone proteins and the pro-aggregatory protein TPPP/p25α or to the aggregation of TPPP/p25α on its own, is causally related to the protein aggregation process in a variety of neurodegenerative diseases. © 2008 Wiley-Liss, Inc.},
	language = {en},
	number = {16},
	urldate = {2018-05-21},
	journal = {Glia},
	author = {Goldbaum, Olaf and Jensen, Poul Henning and Richter‐Landsberg, Christiane},
	month = dec,
	year = {2008},
	keywords = {Animals, Brain, Carrier Proteins, Cell Differentiation, Cells, Centrosome, Cultured, Developmental, Enzyme Inhibitors, Gene Expression Regulation, Inclusion Bodies, Leupeptins, MSA, Nerve Tissue Proteins, Nocodazole, Oligodendroglia, Peptide Hydrolases, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Rats, Tubulin, Tubulin Modulators, Up-Regulation, Wistar, glial inclusion body, microtubules, proteolytic stress, α-synuclein},
	pages = {1736--1746},
}

@article{barbour_d_l_excitatory_2008,
	title = {Excitatory {Local} {Connections} of {Superficial} {Neurons} in {Rat} {Auditory} {Cortex}},
	volume = {28},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.2093-08.2008},
	abstract = {The mammalian cerebral cortex consists of multiple areas specialized for processing information for many different sensory modalities. Although the basic structure is similar for each cortical area, specialized neural connections likely mediate unique information processing requirements. Relative to primary visual (V1) and somatosensory (S1) cortices, little is known about the intrinsic connectivity of primary auditory cortex (A1). To better understand the flow of information from the thalamus to and through rat A1, we made use of a rapid, high-throughput screening method exploiting laser-induced uncaging of glutamate to construct excitatory input maps of individual neurons. We found that excitatory inputs to layer 2/3 pyramidal neurons were similar to those in V1 and S1; these cells received strong excitation primarily from layers 2-4. Both anatomical and physiological observations, however, indicate that inputs and outputs of layer 4 excitatory neurons in A1 contrast with those in V1 and S1. Layer 2/3 pyramids in A1 have substantial axonal arbors in layer 4, and photostimulation demonstrates that these pyramids can connect to layer 4 excitatory neurons. Furthermore, most or all of these layer 4 excitatory neurons project out of the local cortical circuit. Unlike S1 and V1, where feedback to layer 4 is mediated exclusively by indirect local circuits involving layer 2/3 projections to deep layers and deep feedback to layer 4, layer 4 of A1 integrates thalamic and strong layer 4 recurrent excitatory input with relatively direct feedback from layer 2/3 and provides direct cortical output.},
	language = {eng},
	number = {44},
	journal = {The Journal of Neuroscience: The Official Journal of the Society for Neuroscience},
	author = {{Barbour, D. L.} and Callaway, Edward M.},
	month = oct,
	year = {2008},
	pmid = {18971460},
	pmcid = {PMC2610470},
	keywords = {Animals, Auditory Cortex, Excitatory Postsynaptic Potentials, Neurons, Photic Stimulation, Pyramidal Cells, Rats, Rats, Long-Evans},
	pages = {11174--11185},
}

@article{vibet_sensitization_2008,
	title = {Sensitization by docosahexaenoic acid ({DHA}) of breast cancer cells to anthracyclines through loss of glutathione peroxidase ({GPx}1) response},
	volume = {44},
	issn = {0891-5849},
	doi = {10.1016/j.freeradbiomed.2008.01.009},
	abstract = {Docosahexaenoic acid (DHA, a lipid of marine origin) has been found to enhance the activity of several anticancer drugs through an oxidative mechanism. To examine the relation between chemosensitization by DHA and tumor cells antioxidant status, we used two breast cancer cell lines: MDA-MB-231, in which DHA increases sensitivity to doxorubicin, and MCF-7, which does not respond to DHA. Under these conditions, reactive oxygen species (ROS) level increased on anthracycline treatment only in MDA-MB-231. This was concomitant with a decreased cytosolic glutathione peroxidase (GPx1) activity, a crucial enzyme for protection against hydrogen and lipid peroxides, while major antioxidant enzyme activities increased in both cell lines in response to ROS. GPx-decreased activity was accompanied by an accumulation of glutathione, the GPx cosubstrate, and resulted from a decreased amount of GPx protein. In rat mammary tumors, when a DHA dietary supplementation led to an increased tumor sensitivity to anthracyclines, GPx1 activity was similarly decreased. Furthermore, vitamin E abolished both DHA effects on chemotherapy efficacy enhancement and on GPx1 inhibition. Thus, loss of GPx response to an oxidative stress in transformed cells may account for the ability of peroxidizable targets such as DHA to enhance tumor sensitivity to ROS-generating anticancer drugs.},
	number = {7},
	journal = {Free radical biology \& medicine},
	author = {Vibet, Sophie and Goupille, Caroline and Bougnoux, Philippe and Steghens, Jean-Paul and Goré, Jacques and Mahéo, Karine},
	month = apr,
	year = {2008},
	pmid = {18267129},
	keywords = {Animals, Anthracyclines, Antineoplastic Agents, Breast Neoplasms, Cell Line, Tumor, Docosahexaenoic Acids, Female, Gene Expression Regulation, Neoplastic, Glutathione, Glutathione Peroxidase, Humans, Mammary Neoplasms, Animal, Oxidative Stress, Rats, Reactive Oxygen Species},
	pages = {1483--1491}
}

@article{haglund_proteomic_2008,
	title = {Proteomic analysis of the {LPS}-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage},
	volume = {27},
	issn = {0945-053X},
	doi = {10.1016/j.matbio.2007.09.009},
	abstract = {Activation of toll-like receptors (TLR) in articular chondrocytes has been reported to increase the catabolic compartment, leading to matrix degradation, while the main consequence of TLR activation in monocytic cells is the expression and secretion of components of the innate immune response, particularly that of inflammatory cytokines. The objective of the work reported here was to obtain a more complete picture of the response repertoire of articular chondrocytes to TLR activation. Mass spectrometry was used to analyse the secretome of stimulated and unstimulated cells. Characterization of TLR expression in rat articular chondrocytes by RT/PCR indicated that TLR4 was the major receptor form. Exposure of these cells to lipopolysaccharide (LPS), the well-characterized TLR4 ligand, induced production not only of the matrix metalloproteinases MMP3 and 13, but also of components traditionally associated with the innate immune response, such as the complement components C1r, C3 and complement factor B, long pentraxin-3 and osteoglycin. Neither TNF-alpha nor IL-1 was detectable in culture media following exposure to LPS. One of the most prominently-induced proteins was the chitinase-like protein, Chi3L1, linking its expression to the innate immune response repertoire of articular chondrocytes. In intact femoral heads, LPS induced expression of Chi3L1 in chondrocytes close to the articular surface, suggesting that only these cells mount a stress response to LPS. Thus articular chondrocytes have a capacity to respond to TLR activation, which results in the expression of matrix metalloproteases as well as subsets of components of the innate immune response without significant increases in the production of inflammatory cytokines. This could influence the erosive processes leading to cartilage degeneration as well as the repair of damaged matrix.},
	language = {eng},
	number = {2},
	journal = {Matrix Biology: Journal of the International Society for Matrix Biology},
	author = {Haglund, Lisbet and Bernier, Suzanne M. and Önnerfjord, Patrik and Recklies, Anneliese D.},
	month = mar,
	year = {2008},
	pmid = {18023983},
	keywords = {Animals, Animals, Newborn, Cartilage, Articular, Cell Line, Cells, Cultured, Chitinase-3-Like Protein 1, Chondrocytes, Complement C3, Culture Media, Conditioned, Cytokines, Extracellular Matrix Proteins, Femur Head, Gene Expression, Glycoproteins, Humans, Immunity, Innate, Lipopolysaccharides, Matrix Metalloproteinases, Secreted, Monocytes, Peptide Hydrolases, Protease Inhibitors, Proteomics, Rats, Rats, Sprague-Dawley, Reverse Transcriptase Polymerase Chain Reaction, Toll-Like Receptors},
	pages = {107--118},
}

Paper  doi  abstract   bibtex   

@article{olsman_relative_2007,
	title = {Relative differences in aryl hydrocarbon receptor-mediated response for 18 polybrominated and mixed halogenated dibenzo-p-dioxins and -furans in cell lines from four different species.},
	volume = {26},
	issn = {0730-7268},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/17941736},
	doi = {10.1897/07-004R.1},
	abstract = {As a consequence of ubiquitous use of brominated organic chemicals, there is a concern for persistent or increasing environmental levels of polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) and mixed polychlorinated and polybrominated dibenzo-p-dioxins/furans (PXDD/Fs). Hence, there is a need to broaden the toxicological and environmental knowledge about these compounds, as a basis for risk assessment. In the study presented here, the relative potencies (REPs) for 18 PBDD/F and PXDD/ F congeners were determined in four dioxin-specific bioassays from different species: dioxin receptor chemically activated luciferase expression assay (DR-CALUX, rat hepatoma cells), TV101L (human hepatoma cells), and GPC.2D (guinea pig adenoma cells), as well as ethoxyresorufin-O-deethylase induction in the fish cell line RTL-W1 (rainbow trout liver cells). The bioassay specific REP factors presented here enable the assessment of the contribution from PBDD/Fs and PXDD/Fs to total 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents (TEQs: toxic equivalents), using bioassay analysis. The PBDD/Fs were found to be equally potent as their chlorinated analogues in the three mammalian assays, whereas the PXDD/Fs showed relatively higher potencies. Of special concern were the 2,3,7,8-substituted penta- and tetrahalogenated congeners, for which mean REPs were {\textbackslash}textgreater or =1. The 2-B-1,3,7,8-CDD (2-bromo-1,3,7,8-tetrachlorodibenzo-p-dioxin) was up to three times more potent than TCDD in individual experiments (on weight basis). The RTL-W1 was less sensitive to the tested compounds with overall 10-fold lower REPs than the mammalian cell lines. Although the REP factors exhibited species-specific differences, overall resembling rank orders of dioxin-like potency were obtained.},
	number = {11},
	journal = {Environmental toxicology and chemistry / SETAC},
	author = {Olsman, Helena and Engwall, Magnus and Kammann, Ulrike and Klempt, Martin and Otte, Jens and van Bavel, Bert and Hollert, Henner},
	month = nov,
	year = {2007},
	pmid = {17941736},
	keywords = {Adenoma, Adenoma: pathology, Animals, Aryl Hydrocarbon, Aryl Hydrocarbon: metabolism, Biological Assay, Brominated, Brominated: toxicity, Dioxins, Dioxins: toxicity, Environmental Pollutants, Environmental Pollutants: toxicity, Flame retardants, Furans, Furans: toxicity, Guinea Pigs, Halogenated, Halogenated: toxicity, Humans, Hydrocarbons, Liver, Liver: drug effects, Liver: pathology, Oncorhynchus mykiss, Rats, Receptors, Risk Assessment, Tetrachlorodibenzodioxin, Tetrachlorodibenzodioxin: toxicity, cell line, unsure},
	pages = {2448--54},
}

Paper  abstract   bibtex   

@article{
 title = {New Analysis of a Rat Feeding Study with a Genetically Modified Maize Reveals Signs of Hepatorenal Toxicity},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 keywords = {ANALYSIS of variance,CORN,EUROPE,EVALUATION,FEMALES,GENETICALLY modified foods,HEALTH risk assessment,HEPATOTOXICOLOGY,MONSANTO Co.,RATS,URINE},
 pages = {596-602},
 volume = {52},
 websites = {10.1007/s00244-006-0149-5,http://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,cookie,url,uid&db=eih&AN=24731977&loginpage=Login.asp&site=ehost-live&scope=site},
 publisher = {Springer Science & Business Media B.V.},
 id = {f5f80385-b335-382c-9f38-4583cca86edb},
 created = {2012-01-05T13:09:04.000Z},
 file_attached = {true},
 profile_id = {1a467167-0a41-3583-a6a3-034c31031332},
 group_id = {0e532975-1a47-38a4-ace8-4fe5968bcd72},
 last_modified = {2012-10-26T12:52:02.000Z},
 tags = {GMO Foods},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 abstract = {Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals. One of these studies performed under the responsibility of Monsanto Company with a transgenic corn MON863 has been subjected to questions from regulatory reviewers in Europe, where it was finally approved in 2005. This necessitated a new assessment of kidney pathological findings, and the results remained controversial. An Appeal Court action in Germany (Münster) allowed public access in June 2005 to all the crude data from this 90-day rat-feeding study. We independently re-analyzed these data. Appropriate statistics were added, such as a multivariate analysis of the growth curves, and for biochemical parameters comparisons between GMO-treated rats and the controls fed with an equivalent normal diet, and separately with six reference diets with different compositions. We observed that after the consumption of MON863, rats showed slight but dose-related significant variations in growth for both sexes, resulting in 3.3% decrease in weight for males and 3.7% increase for females. Chemistry measurements reveal signs of hepatorenal toxicity, marked also by differential sensitivities in males and females. Triglycerides increased by 24–40% in females (either at week 14, dose 11% or at week 5, dose 33%, respectively); urine phosphorus and sodium excretions diminished in males by 31–35% (week 14, dose 33%) for the most important results significantly linked to the treatment in comparison to seven diets tested. Longer experiments are essential in order to indicate the real nature and extent of the possible pathology; with the present data it cannot be concluded that GM corn MON863 is a safe product. [ABSTRACT FROM AUTHOR] Copyright of Archives of Environmental Contamination & Toxicology is the property of Springer Science & Business Media B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)},
 bibtype = {article},
 author = {Séralini, Gilles-Eric and Cellier, Dominique and Vendomois, Joël},
 journal = {Archives of Environmental Contamination & Toxicology},
 number = {4}
}

Paper  abstract   bibtex   

@article{
 title = {Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats},
 type = {article},
 year = {2007},
 keywords = {B.t. Gene,Bacillus thuringiensis (B.t.),Cotton,Rats,Subchronic toxicity,WIDESTRIKE(TM)},
 pages = {1994-2004},
 volume = {45},
 websites = {http://www.sciencedirect.com/science/article/B6T6P-4NNYJDK-1/2/b92516b58958f3d4944e0f5f323d19a1},
 id = {08dde840-b9a6-3b74-9680-4b9c4c0a1c71},
 created = {2012-01-04T21:42:15.000Z},
 file_attached = {true},
 profile_id = {1a467167-0a41-3583-a6a3-034c31031332},
 group_id = {0e532975-1a47-38a4-ace8-4fe5968bcd72},
 last_modified = {2012-02-08T16:13:28.000Z},
 tags = {GMO Foods},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 abstract = {Meal prepared from Cry1F/Cry1Ac transgenic/genetically modified cottonseed (WIDESTRIKE(TM) Insect Protection, hereafter referred to as WIDESTRIKE(TM)) was compared to cottonseed meal prepared from four conventionally bred lines of cotton (three commercial non-transgenic line controls (PHY72, PHY78 and 98M-2983), and a near isoline non-transgenic control (PSC355) in a 90-day dietary study to evaluate safety and nutritional equivalence. Diets were formulated with 10% WIDESTRIKE(TM) cottonseed meal equivalent to 7235 mg/kg/day for males and 7935 mg/kg/day for females. Animals were evaluated by cage-side and hand-held detailed clinical observations, body weight, and feed consumption. Functional tests, motor activity and ophthalmic examinations were conducted pre-exposure and prior to study termination. Standard hematology, clinical chemistry, prothrombin time and urinalysis parameters were evaluated. All rats had a complete necropsy and selected organs were weighed. Histopathologic examinations were performed on all rats fed the diets containing the near isoline non-transgenic control or WIDESTRIKE(TM). Following 90 days of feeding, no adverse effects were observed during the conduct of clinical observations or in any of the parameters measured in this study. This study demonstrated that rodent diets prepared with 10% cottonseed meal from WIDESTRIKE(TM) cottonseeds do not produce any untoward effects and are nutritionally equivalent to cottonseed meals prepared from other, non-transgenic cottonseeds.},
 bibtype = {article},
 author = {Dryzga, M D and Yano, B L and Andrus, A K and Mattsson, J L},
 journal = {Food and Chemical Toxicology},
 number = {10}
}

Paper  doi  bibtex   

@article{grande_dose-response_2006,
	title = {A {Dose}-{Response} {Study} {Following} {In} {Utero} and {Lactational} {Exposure} to {Di}(2-ethylhexyl)phthalate: {Effects} on {Female} {Rat} {Reproductive} {Development}},
	volume = {91},
	issn = {1096-6080},
	url = {http://academic.oup.com/toxsci/article/91/1/247/1672636/A-DoseResponse-Study-Following-In-Utero-and},
	doi = {10.1093/toxsci/kfj128},
	number = {1},
	urldate = {2019-08-29},
	journal = {Toxicological Sciences},
	author = {Grande, Simone Wichert and Andrade, Anderson J. M. and Talsness, Chris E. and Grote, Konstanze and Chahoud, Ibrahim},
	month = may,
	year = {2006},
	note = {Publisher: Narnia},
	keywords = {diethylhexyl phthalate, hepatomegaly, mothers, no-observed-adverse-effect level, offspring, phthalates, plasticizers, pregnancy, rats, rats, wistar, reproductive physiological process, toxic effect, vagina},
	pages = {247--254},
}

Paper  abstract   bibtex   

@article{vaynman_exercise_2006,
	title = {Exercise differentially regulates synaptic proteins associated to the function of {BDNF}.},
	volume = {1070},
	issn = {0006-8993},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/16413508},
	abstract = {We explored the capacity of exercise to impact select events comprising synaptic transmission under the direction of brain-derived neurotrophic factor (BDNF), which may be central to the events by which exercise potentiates synaptic function. We used a specific immunoadhesin chimera (TrkB-IgG) that mimics the BDNF receptor, TrkB, to selectively block BDNF in the hippocampus during 3 days of voluntary wheel running. We measured resultant synapsin I, synaptophysin, and syntaxin levels involved in vesicular pool formation, endocytosis, and exocytosis, respectively. Synapsin I is involved in vesicle pool formation and neurotransmitter release, synaptophysin, in the biogenesis of synaptic vesicles and budding, and syntaxin, in vesicle docking and fusion. Exercise preferentially increased synapsin I and synaptophysin levels, without affecting syntaxin. There was a positive correlation between synapsin I and synaptophysin in exercising rats and synapsin I with the amount of exercise. Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF.},
	number = {1},
	urldate = {2014-02-03},
	journal = {Brain research},
	author = {Vaynman, Shoshanna S and Ying, Zhe and Yin, Dali and Gomez-Pinilla, Fernando},
	month = jan,
	year = {2006},
	pmid = {16413508},
	keywords = {Animals, Brain-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor: antagonists \& i, Brain-Derived Neurotrophic Factor: physiology, Hippocampus, Hippocampus: metabolism, Immunoglobulin G, Immunoglobulin G: genetics, Male, Motor Activity, Motor Activity: physiology, Nerve Tissue Proteins, Nerve Tissue Proteins: metabolism, Rats, Receptor, Recombinant Fusion Proteins, Recombinant Fusion Proteins: pharmacology, Sprague-Dawley, Synapses, Synapses: metabolism, Synapsins, Synapsins: metabolism, Synaptic Transmission, Synaptic Transmission: physiology, Synaptic Vesicles, Synaptic Vesicles: metabolism, Synaptophysin, Synaptophysin: metabolism, trkB, trkB: genetics},
	pages = {124--30},
}

Paper  doi  abstract   bibtex   

@article{kitamura_anti-thyroid_2005,
	title = {Anti-thyroid hormonal activity of tetrabromobisphenol {A}, a flame retardant, and related compounds: {Affinity} to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis.},
	volume = {76},
	issn = {0024-3205},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/15680168},
	doi = {10.1016/j.lfs.2004.08.030},
	abstract = {The thyroid hormone-disrupting activity of tetrabromobisphenol A (TBBPA), a flame retardant, and related compounds was examined. TBBPA, tetrachlorobisphenol A (TCBPA), tetramethylbisphenol A (TMBPA) and 3,3'-dimethylbisphenol A (DMBPA) markedly inhibited the binding of triiodothyronine (T3; 1 x 10(-10) M) to thyroid hormone receptor in the concentration range of 1 x 10(-7)-1 x 10(-4) M, while bisphenol A and 2,2-diphenylpropane were inactive. TBBPA, TCBPA, TMBPA and DMBPA did not exhibit thyroid hormonal activity in a thyroid hormone-responsive reporter assay using a Chinese hamster ovary cell line (CHO-K1) transfected with thyroid hormone receptor alpha1 or beta1, but TBBPA and TCBPA showed significant anti-thyroid hormone effects on the activity of T3 (1 x 10(-8) M) in the concentration range of 3 x 10(-6) - 5 x 10(-5) M. The thyroid hormone-disrupting activity of TBBPA was also examined in terms of the effect on amphibian metamorphosis stimulated by thyroid hormone. TBBPA in the concentration range of 1 x 10(-8) to 1 x 10(-6) M showed suppressive action on T3 (5 x 10(-8) M)-enhancement of Rana rugosa tadpole tail shortening. These facts suggest that TBBPA, TCBPA, TMBPA and DMBPA can act as thyroid hormone-disrupting agents.},
	number = {14},
	journal = {Life sciences},
	author = {Kitamura, Shigeyuki and Kato, Teruhisa and Iida, Mitsuru and Jinno, Norimasa and Suzuki, Tomoharu and Ohta, Shigeru and Fujimoto, Nariaki and Hanada, Hideki and Kashiwagi, Keiko and Kashiwagi, Akihiko},
	month = feb,
	year = {2005},
	pmid = {15680168},
	keywords = {Animals, Antithyroid Agents, Antithyroid Agents: pharmacology, Biological, Biological: drug effects, CHO Cells, Chlorophenols, Chlorophenols: pharmacology, Cricetinae, Female, Flame Retardants: pharmacology, Flame retardants, Genes, Larva, Metamorphosis, Pituitary Gland, Pituitary Gland: drug effects, Pituitary Gland: metabolism, Plasmids, Plasmids: genetics, Polybrominated Biphenyls, Polybrominated Biphenyls: pharmacology, Ranidae, Rats, Receptors, Reporter, Reporter: genetics, Thyroid Hormone, Thyroid Hormone: drug effects, Thyroid Hormone: genetics, Thyroid Hormones, Thyroid Hormones: metabolism, Thyroid Hormones: pharmacology, Triiodothyronine, Triiodothyronine: pharmacology, frelec, tox},
	pages = {1589--601},
}

@article{lindersson_p25alpha_2005,
	title = {p25alpha {Stimulates} alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies},
	volume = {280},
	issn = {0021-9258},
	doi = {10.1074/jbc.M410409200},
	abstract = {Aggregation of the nerve cell protein alpha-synuclein is a characteristic of the common neurodegenerative alpha-synucleinopathies like Parkinson's disease and Lewy body dementia, and it plays a direct pathogenic role as demonstrated by early onset diseases caused by mis-sense mutations and multiplication of the alpha-synuclein gene. We investigated the existence of alpha-synuclein pro-aggregatory brain proteins whose dysregulation may contribute to disease progression, and we identified the brain-specific p25alpha as a candidate that preferentially binds to alpha-synuclein in its aggregated state. Functionally, purified recombinant human p25alpha strongly stimulates the aggregation of alpha-synuclein in vitro as demonstrated by thioflavin-T fluorescence and quantitative electron microscopy. p25alpha is normally only expressed in oligodendrocytes in contrast to alpha-synuclein, which is normally only expressed in neurons. This expression pattern is changed in alpha-synucleinopathies. In multiple systems atrophy, degenerating oligodendrocytes displayed accumulation of p25alpha and dystopically expressed alpha-synuclein in the glial cytoplasmic inclusions. In Parkinson's disease and Lewy body dementia, p25alpha was detectable in the neuronal Lewy body inclusions along with alpha-synuclein. The localization in alpha-synuclein-containing inclusions was verified biochemically by immunological detection in Lewy body inclusions purified from Lewy body dementia tissue and glial cytoplasmic inclusions purified from tissue from multiple systems atrophy. We suggest that p25alpha plays a pro-aggregatory role in the common neurodegenerative disorders hall-marked by alpha-synuclein aggregates.},
	language = {eng},
	number = {7},
	journal = {The Journal of Biological Chemistry},
	author = {Lindersson, Evo and Lundvig, Ditte and Petersen, Christine and Madsen, Peder and Nyengaard, Jens R. and Højrup, Peter and Moos, Torben and Otzen, Daniel and Gai, Wei-Ping and Blumbergs, Peter C. and Jensen, Poul Henning},
	month = feb,
	year = {2005},
	pmid = {15590652},
	keywords = {Amino Acid Sequence, Animals, Brain, Cattle, Cells, Cloning, Cultured, Cytoplasm, Dementia, Humans, Lewy Bodies, Molecular, Molecular Sequence Data, Nerve Tissue Proteins, Neurites, Neurodegenerative Diseases, Neuroglia, Peptide Fragments, Protein Binding, Rats, Synucleins, Trypsin, alpha-Synuclein},
	pages = {5703--5715},
}

@Article{Backwell2004,
  author   = {Patricia R Y Backwell and Michael D Jennions},
  journal  = {Nature},
  title    = {Animal behaviour: {C}oalition among male fiddler crabs.},
  year     = {2004},
  number   = {6998},
  pages    = {417},
  volume   = {430},
  abstract = {Until now, no compelling evidence has emerged from studies of animal
	territoriality to indicate that a resident will strategically help
	a neighbour to defend its territory against an intruder. We show
	here that territory-owning Australian fiddler crabs will judiciously
	assist other crabs in defending their neighbouring territories. This
	cooperation supports the prediction that it is sometimes less costly
	to assist a familiar neighbour than to renegotiate boundaries with
	a new, and possibly stronger, neighbour.},
  doi      = {10.1038/430417a},
  keywords = {Animals, Attention, Brain, Decision Making, Face, Female, Haplorhini, Housing, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Pattern Recognition, Visual, Photic Stimulation, Prefrontal Cortex, Research Support, Non-U.S. Gov't, U.S. Gov't, P.H.S., Visual Perception, Choice Behavior, Cognition, Dopamine, Learning, Schizophrenia, Substance-Related Disorders, Generalization (Psychology), Motor Skills, Non-P.H.S., Nerve Net, Neuronal Plasticity, Perception, Cerebral Cortex, Memory, Neurons, Sound Localization, Synapses, Synaptic Transmission, Neural Pathways, Non-, Acoustic Stimulation, Adult, Age of Onset, Aging, Blindness, Child, Preschool, Infant, Newborn, Pitch Perception, Analysis of Variance, Animal Welfare, Laboratory, Behavior, Animal, Hybridization, Genetic, Maze Learning, Mice, Inbred C57BL, Inbred DBA, Phenotype, Reproducibility of Results, Darkness, Deafness, Finches, Sleep, Sound, Sunlight, Time Factors, Vocalization, Energy Metabolism, Evolution, Fossils, History, Ancient, Hominidae, Biological, Physical Endurance, Running, Skeleton, Walking, Acoustics, Auditory Perception, Cues, Discrimination Learning, Pair Bond, Social Behavior, Songbirds, Adolescent, England, Habituation (Psychophysiology), Korea, Language, Semantics, Vocabulary, Action Potentials, Hippocampus, Pyramidal Cells, Rats, Rotation, Australia, Brachyura, Cooperative Behavior, Logistic Models, Territoriality, 15269757},
}

Paper  doi  abstract   bibtex   

@article{ Barb_2004_277,
  abstract = {Neural spike train decoding algorithms and techniques to compute Shannon
	mutual information are important methods for analyzing how neural
	systems represent biological signals. Decoding algorithms are also
	one of several strategies being used to design controls for brain-machine
	interfaces. Developing optimal strategies to design decoding algorithms
	and compute mutual information are therefore important problems in
	computational neuroscience. We present a general recursive filter
	decoding algorithm based on a point process model of individual neuron
	spiking activity and a linear stochastic state-space model of the
	biological signal. We derive from the algorithm new instantaneous
	estimates of the entropy, entropy rate, and the mutual information
	between the signal and the ensemble spiking activity. We assess the
	accuracy of the algorithm by computing, along with the decoding error,
	the true coverage probability of the approximate 0.95 confidence
	regions for the individual signal estimates. We illustrate the new
	algorithm by reanalyzing the position and ensemble neural spiking
	activity of CA1 hippocampal neurons from two rats foraging in an
	open circular environment. We compare the performance of this algorithm
	with a linear filter constructed by the widely used reverse correlation
	method. The median decoding error for Animal 1 (2) during 10 minutes
	of open foraging was 5.9 (5.5) cm, the median entropy was 6.9 (7.0)
	bits, the median information was 9.4 (9.4) bits, and the true coverage
	probability for 0.95 confidence regions was 0.67 (0.75) using 34
	(32) neurons. These findings improve significantly on our previous
	results and suggest an integrated approach to dynamically reading
	neural codes, measuring their properties, and quantifying the accuracy
	with which encoded information is extracted.},
  added-at = {2009-06-03T11:20:58.000+0200},
  author = {Barbieri, Riccardo and Frank, Loren M and Nguyen, David P and Quirk, Michael C and Solo, Victor and Wilson, Matthew A and Brown, Emery N},
  biburl = {http://www.bibsonomy.org/bibtex/255b36022e10a07e42f0339963a3ba074/hake},
  description = {The whole bibliography file I use.},
  doi = {10.1162/089976604322742038},
  file = {Barb_2004_277.pdf:Barb_2004_277.pdf:PDF},
  interhash = {068c5ef6cfc1453132764740b244f6a5},
  intrahash = {55b36022e10a07e42f0339963a3ba074},
  journal = {Neural Comput.},
  keywords = {(Computer), 15006097 Action Algorithms, Animals, Behavior, Comparative Computer-Assisted, Exploratory Gov't, Hippocampus, Long-Evans, Nerve Net, Networks Neural Neurons, Non-P.H.S., Non-U.S. P.H.S., Potentials, Processes, Processing, Rats, Reaction Reproducibility Research Results, Signal Stochastic Study, Support, Synaptic Time, Transmission, U.S. of},
  month = {February},
  number = {2},
  pages = {277--307},
  pmid = {15006097},
  timestamp = {2006.07.05},
  title = {Dynamic analyses of information encoding in neural ensembles.},
  url = {http://dx.doi.org/10.1162/089976604322742038},
  volume = {16},
  year = {2004}
}

@article{karai_deletion_2004,
	title = {Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control},
	volume = {113},
	issn = {0021-9738},
	doi = {10.1172/JCI20449},
	abstract = {Control of cancer, neuropathic, and postoperative pain is frequently inadequate or compromised by debilitating side effects. Inhibition or removal of certain nociceptive neurons, while retaining all other sensory modalities and motor function, would represent a new therapeutic approach to control severe pain. The enriched expression of transient receptor potential cation channel, subfamily V, member 1 (TRPV1; also known as the vanilloid receptor, VR1) in nociceptive neurons of the dorsal root and trigeminal ganglia allowed us to test this concept. Administration of the potent TRPV1 agonist resiniferatoxin (RTX) to neuronal perikarya induces calcium cytotoxicity by opening the TRPV1 ion channel and selectively ablates nociceptive neurons. This treatment blocks experimental inflammatory hyperalgesia and neurogenic inflammation in rats and naturally occurring cancer and debilitating arthritic pain in dogs. Sensations of touch, proprioception, and high-threshold mechanosensitive nociception, as well as locomotor function, remained intact in both species. In separate experiments directed at postoperative pain control, subcutaneous administration of RTX transiently disrupted nociceptive nerve endings, yielding reversible analgesia. In human dorsal root ganglion cultures, RTX induced a prolonged increase in intracellular calcium in vanilloid-sensitive neurons, while leaving other, adjacent neurons unaffected. The results suggest that nociceptive neuronal or nerve terminal deletion will be effective and broadly applicable as strategies for pain management.},
	language = {eng},
	number = {9},
	journal = {The Journal of Clinical Investigation},
	author = {Karai, Laszlo and Brown, Dorothy C. and Mannes, Andrew J. and Connelly, Stephen T. and Brown, Jacob and Gandal, Michael and Wellisch, Ofer M. and Neubert, John K. and Olah, Zoltan and Iadarola, Michael J.},
	month = may,
	year = {2004},
	pmid = {15124026},
	pmcid = {PMC398431},
	note = {00000 },
	keywords = {Adult, Analgesia, Animals, Calcium, Cells, Cultured, Diterpenes, Dogs, Dose-Response Relationship, Drug, Extravasation of Diagnostic and Therapeutic Materials, Ganglia, Spinal, Humans, Male, Microinjections, Neurons, Afferent, Nociceptors, Pain Management, Pain Measurement, Rats, Rats, Sprague-Dawley, Receptors, Drug, Stereotaxic Techniques, Time Factors, Trigeminal Ganglion},
	pages = {1344--1352}
}

@Article{Polley2004,
  author   = {Daniel B Polley and Marc A Heiser and David T Blake and Christoph E Schreiner and Michael M Merzenich},
  journal  = {Proc Natl Acad Sci U S A},
  title    = {Associative learning shapes the neural code for stimulus magnitude in primary auditory cortex.},
  year     = {2004},
  number   = {46},
  pages    = {16351-6},
  volume   = {101},
  abstract = {Since the dawn of experimental psychology, researchers have sought
	an understanding of the fundamental relationship between the amplitude
	of sensory stimuli and the magnitudes of their perceptual representations.
	Contemporary theories support the view that magnitude is encoded
	by a linear increase in firing rate established in the primary afferent
	pathways. In the present study, we have investigated sound intensity
	coding in the rat primary auditory cortex (AI) and describe its plasticity
	by following paired stimulus reinforcement and instrumental conditioning
	paradigms. In trained animals, population-response strengths in AI
	became more strongly nonlinear with increasing stimulus intensity.
	Individual AI responses became selective to more restricted ranges
	of sound intensities and, as a population, represented a broader
	range of preferred sound levels. These experiments demonstrate that
	the representation of stimulus magnitude can be powerfully reshaped
	by associative learning processes and suggest that the code for sound
	intensity within AI can be derived from intensity-tuned neurons that
	change, rather than simply increase, their firing rates in proportion
	to increases in sound intensity.},
  doi      = {10.1073/pnas.0407586101},
  keywords = {Acoustic Stimulation, Animals, Association Learning, Auditory Cortex, Auditory Threshold, Conditioning (Psychology), Electrophysiology, Loudness Perception, Neuronal Plasticity, Rats, Sprague-Dawley, Reinforcement (Psychology), Research Support, Non-U.S. Gov't, U.S. Gov't, P.H.S., Reward, 15534214},
}

Paper  abstract   bibtex   

@article{reep_rodent_2004,
	title = {A rodent model for investigating the neurobiology of contralateral neglect},
	volume = {17},
	url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15622013},
	abstract = {BACKGROUND: Contralateral neglect is a common and disabling sequela of right hemisphere strokes. Neglect involves attentional and cognitive deficits, including distortions of contralateral spatial and personal awareness. There are no established successful therapies for neglect, and treatment is often complicated by anosognosia. The disturbances associated with neglect are debilitating to patients and their families, and presence of neglect is a strong predictor of poor prognosis for recovery. OBJECTIVE: The present report reviews findings from 20 years of research using a rat model of neglect. In the rat, 2 cortical areas that are linked by corticocortical connections have been identified as having a major role in neglect, and these correspond to frontal and parietal fields in primates. These 2 cortical areas also have convergent projections to the dorsocentral striatum, which has been implicated as a crucial subcortical component of the cortical-striatal-thalamic circuitry involved in directed attention and neglect. We discuss the role of the dorsocentral striatum in neglect and recovery and present evidence that induced axonal sprouting may promote functional recovery following cortical lesions that produce neglect. CONCLUSIONS: The rodent model of neglect captures some of the essential behavioral and anatomic features of neglect in humans. This model has helped reveal the pathophysiology of neglect, has suggested a crucial role of the striatum in recovery from neglect, and is being used to investigate potential therapeutic approaches.},
	number = {4},
	journal = {Cognitive and Behavioral Neurology},
	author = {Reep, R.L. and Corwin, J.V. and Cheatwood, J.L. and Van Vleet, T.M. and Heilman, K.M. and Watson, R.T.},
	year = {2004},
	keywords = {\#nosource, *Disease Models, Animal, *Laterality, Agnosia/physiopathology, Animals, Brain Damage, Chronic/physiopathology, Frontal Lobe/*physiopathology, Neostriatum/physiopathology, Parietal Lobe/*physiopathology, Perceptual Disorders/*physiopathology, Rats, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., ⛔ No DOI found},
	pages = {191--194},
}

@Article{Mellars2004,
  author   = {Paul Mellars},
  journal  = {Nature},
  title    = {Neanderthals and the modern human colonization of {E}urope.},
  year     = {2004},
  number   = {7016},
  pages    = {461-5},
  volume   = {432},
  abstract = {The fate of the Neanderthal populations of Europe and western Asia
	has gripped the popular and scientific imaginations for the past
	century. Following at least 200,000 years of successful adaptation
	to the glacial climates of northwestern Eurasia, they disappeared
	abruptly between 30,000 and 40,000 years ago, to be replaced by populations
	all but identical to modern humans. Recent research suggests that
	the roots of this dramatic population replacement can be traced far
	back to events on another continent, with the appearance of distinctively
	modern human remains and artefacts in eastern and southern Africa.},
  doi      = {10.1038/nature03103},
  keywords = {Animals, Attention, Brain, Decision Making, Face, Female, Haplorhini, Housing, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Pattern Recognition, Visual, Photic Stimulation, Prefrontal Cortex, Research Support, Non-U.S. Gov't, U.S. Gov't, P.H.S., Visual Perception, Choice Behavior, Cognition, Dopamine, Learning, Schizophrenia, Substance-Related Disorders, Generalization (Psychology), Motor Skills, Non-P.H.S., Nerve Net, Neuronal Plasticity, Perception, Cerebral Cortex, Memory, Neurons, Sound Localization, Synapses, Synaptic Transmission, Neural Pathways, Non-, Acoustic Stimulation, Adult, Age of Onset, Aging, Blindness, Child, Preschool, Infant, Newborn, Pitch Perception, Analysis of Variance, Animal Welfare, Laboratory, Behavior, Animal, Hybridization, Genetic, Maze Learning, Mice, Inbred C57BL, Inbred DBA, Phenotype, Reproducibility of Results, Darkness, Deafness, Finches, Sleep, Sound, Sunlight, Time Factors, Vocalization, Energy Metabolism, Evolution, Fossils, History, Ancient, Hominidae, Biological, Physical Endurance, Running, Skeleton, Walking, Acoustics, Auditory Perception, Cues, Discrimination Learning, Pair Bond, Social Behavior, Songbirds, Adolescent, England, Habituation (Psychophysiology), Korea, Language, Semantics, Vocabulary, Action Potentials, Hippocampus, Pyramidal Cells, Rats, Rotation, Australia, Brachyura, Cooperative Behavior, Logistic Models, Territoriality, Africa, Archaeology, Emigration and Immigration, Europe, Geography, Phylogeny, Population Dynamics, 15565144},
}

@Article{Antonov2003,
  author   = {Igor Antonov and Irina Antonova and Eric R Kandel and Robert D Hawkins},
  journal  = {Neuron},
  title    = {Activity-dependent presynaptic facilitation and hebbian {LTP} are both required and interact during classical conditioning in {A}plysia.},
  year     = {2003},
  number   = {1},
  pages    = {135-47},
  volume   = {37},
  abstract = {Using a simplified preparation of the Aplysia siphon-withdrawal reflex,
	we previously found that associative plasticity at synapses between
	sensory neurons and motor neurons contributes importantly to classical
	conditioning of the reflex. We have now tested the roles in that
	plasticity of two associative cellular mechanisms: activity-dependent
	enhancement of presynaptic facilitation and postsynaptically induced
	long-term potentiation. By perturbing molecular signaling pathways
	in individual neurons, we have provided the most direct evidence
	to date that each of these mechanisms contributes to behavioral learning.
	In addition, our results suggest that the two mechanisms are not
	independent but rather interact through retrograde signaling.},
  keywords = {Amygdala, Animals, Evaluation Studies, Hippocampus, Human, Learning, Long-Term Potentiation, Memory, Models, Neurological, Neural Pathways, Neuronal Plasticity, Support, Non-U.S. Gov't, Synapses, 2-Amino-5-phosphonovalerate, Electric Stimulation, Isomerism, Rats, Receptors, N-Methyl-D-Aspartate, Neurotransmitter, Valine, Visual Perception, Action Potentials, Calcium Signaling, Central Nervous System, Chelating Agents, Conditioning (Psychology), Cyclic AMP-Dependent Protein Kinases, Enzyme Inhibitors, Excitatory Amino Acid Antagonists, Motor Neurons, Neurons, Afferent, Reaction Time, Reflex, Signal Transduction, U.S. Gov't, P.H.S., Synaptic Transmission, 12526779},
}

@article{svensson_hyperpolarized_2003,
	title = {Hyperpolarized {13C} {MR} angiography using {trueFISP}},
	volume = {50},
	issn = {0740-3194},
	doi = {10.1002/mrm.10530},
	abstract = {A (13)C-enriched water-soluble compound (bis-1,1-(hydroxymethyl)-1-(13)C-cyclopropane-D(8)), with a (13)C-concentration of approximately 200 mM, was hyperpolarized to approximately 15\% using dynamic nuclear polarization, and then used as a contrast medium (CM) for contrast-enhanced magnetic resonance angiography (CE-MRA). The long relaxation times (in vitro: T(1) approximately 82 s, T(2) approximately 18 s; in vivo: T(1) approximately 38 s, T(2) approximately 1.3 s) are ideal for steady-state free precession (SSFP) imaging with a true fast imaging and steady precession (trueFISP) pulse sequence. It was shown both theoretically and experimentally that the optimal flip angle was 180 degrees. CE-MRA was performed in four anesthetized live rats after intravenous injection of 3 ml CM. The angiograms covered the thoracic/abdominal region in two of the animals, and the head-neck region in the other two. Fifteen consecutive images were acquired in each experiment, with a flip-back pulse at the end of each image acquisition. In the angiograms, the vena cava (SNR approximately 240), aorta, renal arteries, carotid arteries (SNR approximately 75), jugular veins, and several other vessels were visible. The SNR in the cardiac region was 500. Magnetization was preserved from one image acquisition to the next using the flip-back technique (SNR(cardiac) approximately 10 in the 15th image).},
	language = {eng},
	number = {2},
	journal = {Magnetic Resonance in Medicine},
	author = {Svensson, Jonas and Månsson, Sven and Johansson, Edvin and Petersson, J. Stefan and Olsson, Lars E.},
	month = aug,
	year = {2003},
	pmid = {12876701},
	keywords = {Animals, Carbon Isotopes, Contrast Media, Injections, Intravenous, Magnetic Resonance Angiography, Male, Rats, Rats, Wistar},
	pages = {256--262},
}

@article{chetkovich_postsynaptic_2002,
	title = {Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms},
	volume = {22},
	issn = {1529-2401},
	doi = {20026598},
	abstract = {Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs including PDZ (postsynaptic density-95/Discs large/zona occludens-1), Src homology 3, and guanylate kinase domains, which regulate signaling and plasticity at excitatory synapses. We report that N-terminal alternative splicing of PSD95 generates an isoform, PSD95beta that contains an additional "L27" motif, which is also present in SAP97. Using yeast two hybrid and coimmunoprecipitation assays, we demonstrate that this N-terminal L27 domain of PSD-95beta, binds to an L27 domain in the membrane-associated guanylate kinase calcium/calmodulin-dependent serine kinase, and to Hrs, an endosomal ATPase that regulates vesicular trafficking. By transfecting heterologous cells and hippocampal neurons, we find that interactions with the L27 domain regulate synaptic clustering of PSD95beta. Disrupting Hrs-regulated early endosomal sorting in hippocampal neurons selectively blocks synaptic clustering of PSD95beta but does not interfere with trafficking of the palmitoylated isoform, PSD95alpha. These studies identify molecular and functional heterogeneity in synaptic PSD95 complexes and reveal critical roles for L27 domain interactions and Hrs regulated vesicular trafficking in postsynaptic protein clustering.},
	language = {eng},
	number = {15},
	journal = {The Journal of Neuroscience: The Official Journal of the Society for Neuroscience},
	author = {Chetkovich, Dane M. and Bunn, Robert C. and Kuo, Sheng-Han and Kawasaki, Yoshimi and Kohwi, Minoree and Bredt, David S.},
	month = aug,
	year = {2002},
	pmid = {12151521},
	pmcid = {PMC6758133},
	keywords = {Adaptor Proteins, Signal Transducing, Alternative Splicing, Amino Acid Motifs, Animals, COS Cells, Calcium-Calmodulin-Dependent Protein Kinases, Cells, Cultured, Disks Large Homolog 4 Protein, Endosomal Sorting Complexes Required for Transport, Guanylate Kinases, Humans, Intracellular Signaling Peptides and Proteins, Macromolecular Substances, Membrane Proteins, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Nucleoside-Phosphate Kinase, Phosphoproteins, Precipitin Tests, Protein Isoforms, Protein Structure, Tertiary, Protein Transport, Rats, Rodentia, Sequence Homology, Amino Acid, Synapses, Two-Hybrid System Techniques},
	pages = {6415--6425},
}

@Article{Sparre_2002_1402,
  author = {Sparre, T. and Christensen, U. B. and Mose Larsen, P. and Fey, S. J. and Wrzesinski, K. and Roepstorff, P. and Mandrup-Poulsen, T. and Pociot, F. and Karlsen, A. E. and Nerup, J.},
 journal = {Diabetologia},
 note = {Comparative Study Journal Article Research Support, Non-U.S. Gov't Germany},
 number = {11},
 pages = {1550-61},
 title = {Il-1beta induced protein changes in diabetes prone BB rat islets of langerhans identified by proteome analysis},
 volume = {45},
 year = {2002},
 keywords = {Animals, Animals, Newborn, Cells, Cultured, Diabetes, Mellitus, Type, 1/*genetics, Electrophoresis, Gel, Two-Dimensional, Enzymes/genetics, Interleukin-1/*pharmacology, Islets, of, Langerhans/cytology/drug, effects/*physiology, Proteins/*genetics/isolation, &, purification, *Proteome, Rats, Rats, Inbred, BB, Rats, Inbred, WF},
 title_with_no_special_chars = {IL1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis}
}

@article{ clement_genetic_2002,
  title = {Genetic basis of anxiety-like behaviour: a critical review},
  volume = {57},
  issn = {0361-9230},
  shorttitle = {Genetic basis of anxiety-like behaviour},
  abstract = {The way genetic and/or environmental factors influence psychiatric disorders is an enduring question in the field of human psychiatric diseases. Anxiety-related disorders provide a relevant example of how such an interaction is involved in the aetiology of a psychiatric disease. In this paper we review the literature on that subject, reporting data derived from human and rodent studies. We present in a critical way the animal models used in the studies aimed at investigating the genetic basis of anxiety, including inbred mice, selected lines, multiple marker strains, or knockout mice and review data reporting environmental components influencing anxiety-related behaviours. We conclude that anxiety is a complex behaviour, underlined not only by genetic or environmental factors but also by multiple interactions between these two factors.},
  language = {eng},
  number = {1},
  journal = {Brain Research Bulletin},
  author = {Clément, Yan and Calatayud, François and Belzung, Catherine},
  month = {January},
  year = {2002},
  pmid = {11827738},
  keywords = {Animals, Anxiety, Chromosome Mapping, Disease Models, Animal, Environment, Gene Targeting, Genetic Predisposition to Disease, Humans, Mice, Mice, Inbred Strains, Neurotransmitter Agents, Rats},
  pages = {57--71}
}

@Article{Gawne2002,
  author   = {Timothy J Gawne and Julie M Martin},
  journal  = {J Neurophysiol},
  title    = {Responses of primate visual cortical {V}4 neurons to simultaneously presented stimuli.},
  year     = {2002},
  number   = {3},
  pages    = {1128-35},
  volume   = {88},
  abstract = {We report here results from 45 primate V4 visual cortical neurons
	to the preattentive presentations of seven different patterns located
	in two separate areas of the same receptive field and to combinations
	of the patterns in the two locations. For many neurons, we could
	not determine any clear relationship for the responses to two simultaneous
	stimuli. However, for a substantial fraction of the neurons we found
	that the firing rate was well modeled as the maximum firing rate
	of each stimulus presented separately. It has previously been proposed
	that taking the maximum of the inputs ("MAX" operator) could be a
	useful operation for neurons in visual cortex, although there has
	until now been little direct physiological evidence for this hypothesis.
	Our results here provide direct support for the hypothesis that the
	MAX operator plays a significant (although certainly not exclusive)
	role in generating the receptive field properties of visual cortical
	neurons.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, 12205134},
}

@Article{Pinker2002a,
  author   = {Steven Pinker and Michael T Ullman},
  journal  = {Trends Cogn Sci},
  title    = {The past and future of the past tense.},
  year     = {2002},
  number   = {11},
  pages    = {456-463},
  volume   = {6},
  abstract = {What is the interaction between storage and computation in language
	processing? What is the psychological status of grammatical rules?
	What are the relative strengths of connectionist and symbolic models
	of cognition? How are the components of language implemented in the
	brain? The English past tense has served as an arena for debates
	on these issues. We defend the theory that irregular past-tense forms
	are stored in the lexicon, a division of declarative memory, whereas
	regular forms can be computed by a concatenation rule, which requires
	the procedural system. Irregulars have the psychological, linguistic
	and neuropsychological signatures of lexical memory, whereas regulars
	often have the signatures of grammatical processing. Furthermore,
	because regular inflection is rule-driven, speakers can apply it
	whenever memory fails.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, 12457895},
}

@Article{Freedman2002,
  author   = {David J Freedman and Maximilian Riesenhuber and Tomaso Poggio and Earl K Miller},
  journal  = {J Neurophysiol},
  title    = {Visual categorization and the primate prefrontal cortex: {N}europhysiology and behavior.},
  year     = {2002},
  number   = {2},
  pages    = {929-41},
  volume   = {88},
  abstract = {The ability to group stimuli into meaningful categories is a fundamental
	cognitive process. To explore its neuronal basis, we trained monkeys
	to categorize computer-generated stimuli as "cats" and "dogs." A
	morphing system was used to systematically vary stimulus shape and
	precisely define a category boundary. Psychophysical testing and
	analysis of eye movements suggest that the monkeys categorized the
	stimuli by attending to multiple stimulus features. Neuronal activity
	in the lateral prefrontal cortex reflected the category of visual
	stimuli and changed with learning when a monkey was retrained with
	the same stimuli assigned to new categories. Further, many neurons
	showed activity that appeared to reflect the monkey's decision about
	whether two stimuli were from the same category or not. These results
	suggest that the lateral prefrontal cortex is an important part of
	the neuronal circuitry underlying category learning and category-based
	behaviors.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, 12163542},
}

Paper  doi  abstract   bibtex   

@article{steiniger_perifollicular_2001,
	title = {The perifollicular and marginal zones of the human splenic white pulp : do fibroblasts guide lymphocyte immigration?},
	volume = {159},
	issn = {0002-9440},
	shorttitle = {The perifollicular and marginal zones of the human splenic white pulp},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11485909},
	doi = {10.1016/S0002-9440(10)61722-1},
	abstract = {We investigate the white pulp compartments of 73 human spleens and demonstrate that there are several microanatomical peculiarities in man that do not occur in rats or mice. Humans lack a marginal sinus separating the marginal zone (MZ) from the follicles or the follicular mantle zone. The MZ is divided into an inner and an outer compartment by a special type of fibroblasts. An additional compartment, termed the perifollicular zone, is present between the follicular MZ and the red pulp. The perifollicular zone contains sheathed capillaries and blood-filled spaces without endothelial lining. In the perifollicular zone, in the outer MZ, and in the T cell zone fibroblasts of an unusual phenotype occur. These cells stain for the adhesion molecules MAdCAM-1, VCAM-1 (CD106), and VAP-1; the Thy-1 (CD90) molecule; smooth muscle alpha-actin and smooth muscle myosin; cytokeratin 18; and thrombomodulin (CD141). They are, however, negative for the peripheral node addressin, the cutaneous lymphocyte antigen, CD34, PECAM-1 (CD31), and P- and E-selectin (CD62P and CD62E). In the MZ the fibroblasts are often tightly associated with CD4-positive T lymphocytes, whereas CD8-positive cells are almost absent. Our findings lead to the hypothesis, that recirculating CD4-positive T lymphocytes enter the human splenic white pulp from the open circulation of the perifollicular zone without crossing an endothelium. Specialized fibroblasts may attract these T cells and guide them into the periarteriolar T cell area.},
	number = {2},
	urldate = {2012-03-26},
	journal = {The American Journal of Pathology},
	author = {Steiniger, B and Barth, P and Hellinger, A},
	month = aug,
	year = {2001},
	pmid = {11485909},
	keywords = {Actins, Adult, Animals, Antigens, CD, Biological Markers, Cell Adhesion Molecules, Female, Fibroblasts, Humans, Keratins, Lymphocytes, Male, Mice, Myosins, Rats, Spleen, Splenectomy},
	pages = {501--512},
}

@Article{Wolff2001,
  author   = {C Wolff and E Schr\"oger},
  journal  = {Brain Res Cogn Brain Res},
  title    = {Activation of the auditory pre-attentive change detection system by tone repetitions with fast stimulation rate.},
  year     = {2001},
  number   = {3},
  pages    = {323-7},
  volume   = {10},
  abstract = {The human automatic pre-attentive change detection system indexed
	by the mismatch negativity (MMN) component of the auditory event-related
	brain potential is known to be highly adaptive. The present study
	showed that even infrequent repetitions of tones can elicit MMN,
	independently of attention, when tones of varying frequency are rapidly
	presented in an isochronous rhythm. This demonstrates that frequency
	variation can be extracted as an invariant feature of the acoustic
	environment revealing the capacity for adaptation of the auditory
	pre-attentive change detection system. It is argued that this capacity
	is related to the temporal-window of integration.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, Broca, Encephalitis, Herpes Simplex, Infarction, Middle Cerebral Artery, X-Ray Computed, 11167055},
}

@Article{Fiser2001,
  author   = {J Fiser and Richard N Aslin},
  journal  = {Psychol Sci},
  title    = {Unsupervised statistical learning of higher-order spatial structures from visual scenes.},
  year     = {2001},
  number   = {6},
  pages    = {499-504},
  volume   = {12},
  abstract = {Three experiments investigated the ability of human observers to extract
	the joint and conditional probabilities of shape co-occurrences during
	passive viewing of complex visual scenes. Results indicated that
	statistical learning of shape conjunctions was both rapid and automatic,
	as subjects were not instructed to attend to any particularfeatures
	of the displays. Moreover, in addition to single-shape frequency,
	subjects acquired in parallel several different higher-order aspects
	of the statistical structure of the displays, including absolute
	shape-position relations in an array, shape-pair arrangements independent
	of position, and conditional probabilities of shape co-occurrences.
	Unsupervised learning of these higher-order statistics provides support
	for Barlow's theory of visual recognition, which posits that detecting
	"suspicious coincidences" of elements during recognition is a necessary
	prerequisite for efficient learning of new visual features.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, 11760138},
}

@Article{Scholl2001b,
  author   = {B. J. Scholl},
  journal  = {Cognition},
  title    = {Objects and attention: {T}he state of the art.},
  year     = {2001},
  number   = {1-2},
  pages    = {1-46},
  volume   = {80},
  abstract = {What are the units of attention? In addition to standard models holding
	that attention can select spatial regions and visual features, recent
	work suggests that in some cases attention can directly select discrete
	objects. This paper reviews the state of the art with regard to such
	'object-based' attention, and explores how objects of attention relate
	to locations, reference frames, perceptual groups, surfaces, parts,
	and features. Also discussed are the dynamic aspects of objecthood,
	including the question of how attended objects are individuated in
	time, and the possibility of attending to simple dynamic motions
	and events. The final sections of this review generalize these issues
	beyond vision science, to other modalities and fields such as auditory
	objects of attention and the infant's 'object concept'.},
  keywords = {80 and over, Adenoviridae, Adolescent, Adult, Aged, Analysis of Variance, Animals, Attention, Auditory Perception, Biopsy, Bone Nails, Bone Neoplasms, Bone Screws, Bone Transplantation, Breast Neoplasms, Carcinoma, Child, Child Development, Cognition, Cohort Studies, Comparative Study, Concept Formation, Constriction, Esophageal Neoplasms, Female, Femoral Neck Fractures, Femoral Neoplasms, Femur Head, Femur Neck, Fibula, Follow-Up Studies, Fracture Fixation, Fractures, Gene Expression, Gene Transfer Techniques, Green Fluorescent Proteins, Hepatitis, Homologous, Humans, Inbred Strains, Infant, Injections, Internal, Intramedullary, Intravenous, Judgment, Knee Joint, Liver, Luminescent Proteins, Male, Meta-Analysis, Middle Aged, Models, Motion, Motion Perception, Needle, Neoplasms, Non-P.H.S., Non-U.S. Gov't, P.H.S., Perceptual Distortion, Portal Vein, Preschool, Problem Solving, Psychological, Radiation-Induced, Rats, Research Support, Retrospective Studies, Second Primary, Self Concept, Sensitivity and Specificity, Social Perception, Space Perception, Spontaneous, Squamous Cell, Students, Time Factors, Tomography, Transplantation, Treatment Outcome, U.S. Gov't, Visual Perception, X-Ray Computed, 11245838},
}

Paper  Website  abstract   bibtex   

@article{
 title = {Understanding human disease mutations through the use of interspecific genetic variation},
 type = {article},
 year = {2001},
 identifiers = {[object Object]},
 keywords = {*Evolution, Molecular,Amino Acids/genetics,Animals,Cattle,Cricetinae,Cystic Fibrosis Transmembrane Conductance Regulato,Databases, Nucleic Acid,Eye Proteins/genetics,Gene Frequency,Genetic Predisposition to Disease/*genetics,Glucosephosphate Dehydrogenase/genetics,Homeodomain Proteins/genetics,Humans,Leukocyte L1 Antigen Complex,Membrane Glycoproteins/genetics,Mice,Mutation,Neural Cell Adhesion Molecules/genetics,Paired Box Transcription Factors,Phenylalanine Hydroxylase/genetics,Phylogeny,Polymorphism, Single Nucleotide,Rats,Repressor Proteins/genetics,Research Support, Non-U.S. Gov't,Research Support, U.S. Gov't, Non-P.H.S.,Research Support, U.S. Gov't, P.H.S.,Species Specificity,Tumor Suppressor Proteins,Variation (Genetics)},
 pages = {2319-2328},
 volume = {10},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11689479},
 id = {615db8bf-ae06-347d-a726-890771c0ab9a},
 created = {2017-06-19T13:46:04.109Z},
 file_attached = {true},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:46:04.233Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 notes = {<m:note>0964-6906 (Print)<m:linebreak/>Journal Article</m:note>},
 abstract = {Data on replacement mutations in genes of disease patients exist in a variety of online resources. In addition, genome sequencing projects and individual gene sequencing efforts have led to the identification of disease gene homologs in diverse metazoan species. The availability of these two types of information provides unique opportunities to investigate factors that are important in the development of genetically based disease by contrasting long and short-term molecular evolutionary patterns. Therefore, we conducted an analysis of disease-associated human genetic variation for seven disease genes: the cystic fibrosis transmembrane conductance regulator, glucose-6-phosphate dehydrogenase, the neural cell adhesion molecule L1, phenylalanine hydroxylase, paired box 6, the X-linked retinoschisis gene and TSC2/tuberin. Our analyses indicate that disease mutations show definite patterns when examined from an evolutionary perspective. Human replacement mutations resulting in disease are overabundant at amino acid positions most conserved throughout the long-term history of metazoans. In contrast, human polymorphic replacement mutations and silent mutations are randomly distributed across sites with respect to the level of conservation of amino acid sites within genes. Furthermore, disease-causing amino acid changes are of types usually not observed among species. Using Grantham's chemical difference matrix, we find that amino acid changes observed in disease patients are far more radical than the variation found among species and in non-diseased humans. Overall, our results demonstrate the usefulness of evolutionary analyses for understanding patterns of human disease mutations and underscore the biomedical significance of sequence data currently being generated from various model organism genome sequencing projects.},
 bibtype = {article},
 author = {Miller, M P and Kumar, S},
 journal = {Hum Mol Genet},
 number = {21}
}

@Article{Blankenberg_2001_1510,
  author = {Blankenberg, F. G. and Tait, J. F. and Blankenberg, T. A. and Post, A. M. and Strauss, H. W.},
 journal = {Eur J Nucl Med},
 note = {Hl-61717/hl/nhlbi Journal Article Research Support, U.S. Gov't, P.H.S. Germany},
 number = {9},
 pages = {1384-93},
 title = {Imaging macrophages and the apoptosis of granulocytes in a rodent model of subacute and chronic abscesses with radiolabeled monocyte chemotactic peptide-1 and annexin V},
 volume = {28},
 year = {2001},
 keywords = {Abscess/pathology/*radionuclide, imaging, Animals, Annexin, A5/*diagnostic, use, *Apoptosis, Autoradiography, Chemokine, CCL2/*diagnostic, use/pharmacokinetics, Chronic, Disease, Granulocytes/*radionuclide, imaging, Hindlimb, Macrophages/*radionuclide, imaging, Male, Monocytes/radionuclide, imaging, Rats, Rats, Sprague-Dawley, Recombinant, Proteins/diagnostic, use, Scintillation, Counting, Serum, Albumin, Bovine/diagnostic, use, Serum, Albumin, Radio-Iodinated/diagnostic, use, Technetium/*diagnostic, use/pharmacokinetics, Tissue, Distribution},
 title_with_no_special_chars = {Imaging macrophages and the apoptosis of granulocytes in a rodent model of subacute and chronic abscesses with radiolabeled monocyte chemotactic peptide1 and annexin V}
}

@Article{Thoroughman2000,
  author   = {KA Thoroughman and R Shadmehr},
  journal  = {Nature},
  title    = {Learning of action through adaptive combination of motor primitives.},
  year     = {2000},
  number   = {6805},
  pages    = {742-7},
  volume   = {407},
  abstract = {Understanding how the brain constructs movements remains a fundamental
	challenge in neuroscience. The brain may control complex movements
	through flexible combination of motor primitives, where each primitive
	is an element of computation in the sensorimotor map that transforms
	desired limb trajectories into motor commands. Theoretical studies
	have shown that a system's ability to learn action depends on the
	shape of its primitives. Using a time-series analysis of error patterns,
	here we show that humans learn the dynamics of reaching movements
	through a flexible combination of primitives that have gaussian-like
	tuning functions encoding hand velocity. The wide tuning of the inferred
	primitives predicts limitations on the brain's ability to represent
	viscous dynamics. We find close agreement between the predicted limitations
	and the subjects' adaptation to new force fields. The mathematical
	properties of the derived primitives resemble the tuning curves of
	Purkinje cells in the cerebellum. The activity of these cells may
	encode primitives that underlie the learning of dynamics.},
  doi      = {10.1038/35037588},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, Sensory Thresholds, Sound, Language Disorders, Preschool, Generalization (Psychology), Vocabulary, Biophysics, Nerve Net, Potassium Channels, Sodium Channels, Cues, Differential Threshold, Arousal, Newborn, Sucking Behavior, Ferrets, Microelectrodes, Gestalt Theory, Mathematical Computing, Perceptual Closure, Vestibulocochlear Nerve, Brain Damage, Chronic, Regional Blood Flow, Thinking, Tomography, Emission-Computed, Case-Control Studies, Multivariate Analysis, Artificial Intelligence, Depth Perception, 11048700},
}

Website  abstract   bibtex   

@article{
 title = {Dynamic seeding and in vitro culture of hepatocytes in a flow perfusion system.},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Albumins,Albumins: secretion,Animals,Biocompatible Materials,Biomedical Engineering,Cell Culture Techniques,Cell Culture Techniques: methods,Cell Survival,Cell Transplantation,Electron,Liver,Liver Transplantation,Liver: cytology,Liver: physiology,Microscopy,Perfusion,Polyglycolic Acid,Rats,Scanning},
 pages = {39-44},
 volume = {6},
 websites = {http://online.liebertpub.com/doi/abs/10.1089/107632700320874},
 month = {2},
 publisher = {Mary Ann Liebert, Inc.},
 day = {9},
 id = {db57a436-04ea-3e50-83e2-1cad83b9dd51},
 created = {2016-06-24T20:49:55.000Z},
 accessed = {2015-12-07},
 file_attached = {false},
 profile_id = {954a987f-819f-3985-95a4-2991e0cf0552},
 group_id = {8440dcff-74cc-3783-aef7-fe2749cfc7ef},
 last_modified = {2016-06-24T20:49:55.000Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 citation_key = {Kim2000},
 language = {en},
 abstract = {Our laboratory has investigated hepatocyte transplantation using biodegradable polymer matrices as an alternative treatment to end-stage liver disease. One of the major limitations has been the insufficient survival of an adequate mass of transplanted cells. This study investigates a novel method of dynamic seeding and culture of hepatocytes in a flow perfusion system. In experiment I, hepatocytes were flow-seeded onto PGA scaffolds and cultured in a flow perfusion system for 24 h. Overall metabolic activity and distribution of cells were assessed by their ability to reduce MTT. DNA quantification was used to determine the number of cells attached. Culture medium was analyzed for albumin content. In Experiment II, hepatocyte/polymer constructs were cultured in a perfusion system for 2 and 7 days. The constructs were examined by SEM and histology. Culture medium was analyzed for albumin. In experiment I, an average of 4.4 X 10(6) cells attached to the scaffolds by DNA quantification. Cells maintained a high metabolic activity and secreted albumin at a rate of 13 pg/cell/day. In experiment II, SEM demonstrated successful attachment of hepatocytes on the scaffolds after 2 and 7 days. Cells appeared healthy on histology and maintained a high rate of albumin secretion through day 7. Hepatocytes can be dynamically seeded onto biodegradable polymers and survive with a high rate of albumin synthesis in the flow perfusion culture system.},
 bibtype = {article},
 author = {Kim, S S and Sundback, C A and Kaihara, S and Benvenuto, M S and Kim, B S and Mooney, D J and Vacanti, J P},
 journal = {Tissue engineering},
 number = {1}
}

Paper  abstract   bibtex   

@article{fleshner_exercise_2000,
	title = {Exercise and neuroendocrine regulation of antibody production: protective effect of physical activity on stress-induced suppression of the specific antibody response.},
	volume = {21 Suppl 1},
	issn = {0172-4622},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/10893019},
	abstract = {It has been convincingly demonstrated that the in vivo immune response is not fully autonomous. Clearly, functional interactions exist between the neuroendocrine system and the immune system that operate during the generation of normal in vivo immune responses. In addition to playing an important regulatory role in the absence of perturbation, the same neuroendocrine signals that facilitate immune function in a nonstressed organism may suppress immune function in a physiologically or psychologically stressed organism. Given the complexity of these interactions, the current paper will focus on neuroendocrine modulation of one important dimension of acquired immunity, the in vivo antibody response to a benign protein (keyhole limpet hemocyanin, KLH). In addition, only the hypothalamic-pituitary-adrenal (corticosterone) response and the sympathetic nervous system (norepinephrine and epinephrine) response will be discussed. The current paper will 1) examine the cellular steps involved in the antibody response to KLH; 2) describe the specific cellular consequences of acute stressor exposure on this response; 3) describe the evidence for corticosterone and catecholamine modulation of the in vivo antibody response during quiescent and stressed states; and 4) present data that support the hypothesis that regular, moderate, physical activity can prevent the neuroendocrine and detrimental immunological effects of stress.},
	urldate = {2014-03-19},
	journal = {International journal of sports medicine},
	author = {Fleshner, M},
	month = may,
	year = {2000},
	pmid = {10893019},
	keywords = {Adolescent, Animals, Antibody Formation, Antibody Formation: physiology, Corticosterone, Corticosterone: blood, Corticosterone: immunology, Exercise, Exercise: physiology, Female, Hemocyanin, Hemocyanin: immunology, Humans, Neuroimmunomodulation, Neuroimmunomodulation: physiology, Neurosecretory Systems, Neurosecretory Systems: immunology, Neurosecretory Systems: physiology, Norepinephrine, Norepinephrine: blood, Norepinephrine: immunology, Rats, Stress, Physiological, Stress, Physiological: immunology, Stress, Physiological: pathology},
	pages = {S14--9},
}

@Article{Hahn2000,
  author   = {U Hahn and RC Nakisa},
  journal  = {Cognit Psychol},
  title    = {German inflection: {S}ingle route or dual route?},
  year     = {2000},
  number   = {4},
  pages    = {313-60},
  volume   = {41},
  abstract = {The German plural system has recently become a focal point for conflicting
	theories of language, both linguistic and cognitive. Marcus et al.
	(1995) highlight the German plural as support for the dual-route
	account of inflectional morphology first proposed by Pinker and colleagues
	(Pinker & Prince, 1988). On the dual-route account, inflectional
	morphology is universally subserved by a symbolic rule route which
	deals with regular inflection and an associative memory component
	which deals with irregular inflection. This contrasts with single-route
	connectionist systems. We seek to counter supposed evidence for the
	dual-route account through large-scale simulations as well as through
	experimental data. We argue that, in its current form, the dual-route
	account is incapable of generating experimental data provided by
	Marcus et al. (1995) as support. Finally, we provide direct quantitative
	comparisons between single-route and dual-route models of German
	plural inflection and find single-route performance superior on these
	tests.},
  doi      = {10.1006/cogp.2000.0737},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, 11121259},
}

@article{
 title = {Norway rats (Rattus norvegicus) on Fregate Island, Seychelles: The invasion; subsequent eradication attempts and implications for the island's fauna},
 type = {article},
 year = {2000},
 identifiers = {[object Object]},
 keywords = {Conservation,Eradication,Invasion,Island management,Rats,Rattus norvegicus,Seychelles},
 pages = {133-138},
 volume = {96},
 id = {52715239-e09c-3ed2-ab8e-efae0de30a21},
 created = {2014-11-12T15:37:26.000Z},
 file_attached = {false},
 profile_id = {e77fd8b5-61ed-3cb6-9a8d-ead8c87a9123},
 group_id = {886a50df-fbf3-30e6-9d6b-6771e376eacf},
 last_modified = {2015-08-21T02:37:45.000Z},
 tags = {Rattus norvegicus},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 abstract = {In July 1995 Fregate Island in the Seychelles was colonised by Norway rats (Rattus norvegicus). Prior to this date, Fregate was the largest rat-free island in the inner, granitic, group of the Seychelles archipelago. An eradication attempt was made in June 1996 to protect the unique fauna of the island, including the critically endangered Seychelles magpie-robin (Copsychus sechellarum). This was the first time an attempt had been made to eradicate a newly arrived and rapidly expanding rat population. The attempt was abandoned after several Seychelles magpie-robins died through secondary rodenticide poisoning. Possible biological consequences of continued rat presence on Fregate Island are discussed and recommendations made that are relevant to other invasions of islands by rats. This is the first time that a rat invasion of a biologically important conservation island has been documented in any depth. (C) 2000 Elsevier Science Ltd.},
 bibtype = {article},
 author = {Thorsen, M. and Shorten, R. and Lucking, R. and Lucking, V.},
 journal = {Biological Conservation},
 number = {2}
}

@Article{Eimas1999,
  author   = {PD Eimas},
  journal  = {Science},
  title    = {Do infants learn grammar with algebra or statistics?},
  year     = {1999},
  number   = {5413},
  pages    = {435-6; author reply 436-7},
  volume   = {284},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, 9872745},
}

@Article{Krebs1999,
  author   = {HI Krebs and ML Aisen and BT Volpe and N Hogan},
  journal  = {Proc Natl Acad Sci U S A},
  title    = {Quantization of continuous arm movements in humans with brain injury.},
  year     = {1999},
  number   = {8},
  pages    = {4645-9},
  volume   = {96},
  abstract = {Segmentation of apparently continuous movement has been reported for
	over a century by human movement researchers, but the existence of
	primitive submovements has never been proved. In 20 patients recovering
	from a single cerebral vascular accident (stroke), we identified
	the apparent submovements that composed a continuous arm motion in
	an unloaded task. Kinematic analysis demonstrated a submovement speed
	profile that was invariant across patients with different brain lesions
	and provided experimental verification of the detailed shape of primitive
	submovements. The submovement shape was unaffected by its peak speed,
	and to test further the invariance of shape with speed, we analyzed
	movement behavior in a patient with myoclonus. This patient occasionally
	made involuntary shock-like arm movements, which occurred near the
	maximum capacity of the neuromuscular system, exhibited speed profiles
	that were comparable to those identified in stroke patients, and
	were also independent of speed.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, 10200316},
}

Paper  abstract   bibtex   

@article{sun_altered_1997,
	title = {Altered phospholipid metabolism in sodium butyrate-induced differentiation of {C6} glioma cells},
	volume = {32},
	issn = {0024-4201},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/9076664},
	abstract = {We examined the changes in phospholipid metabolisms in sodium butyrate-treated C6 glioma cells. Treatment of 2.5 mM sodium butyrate for 24 h induced an increase in the activity of glutamine synthetase, suggesting that these cells were under differentiation. Similar treatment was associated with (i) increased arachidonic acid incorporation into phosphatidylcholine, and (ii) decreased arachidonic acid incorporation into phosphatidylinositol and (iii) phosphatidylethanolamine. These effects were subsequently investigated by examining the acylation process, de novo biosynthesis, and the agonist-stimulated phosphoinositides hydrolysis in these cells. Our results indicated that sodium butyrate stimulated the acylation of arachidonic acid into lysophosphatidylcholine, lysophosphatidylethanolamine, and lysophosphatidylinositol. The glycerol incorporation into these lipids was not affected, but the inositol incorporation into total chloroform extracts and Pl and phosphatidylinositol 4-phosphate was decreased in the sodium butyrate-treated cells. Moreover, the accumulation of the rapid histamine-stimulated phosphoinositide metabolites, i.e., inositol monophosphate, inositol diphosphate, and inositol triphosphate (IP3) was decreased in these cells. To elucidate whether the decreased inositol phosphates were due to a decrease in the phosphoinositides hydrolysis, we measured the transient IP3 production directly by a receptor-binding assay. Our results indicated that histamine-stimulated transient IP3 formations were decreased. Taken together, these results indicated that multiple changes by multiple mechanisms of phospholipid metabolisms were found in sodium butyrate-treated C6 glioma cells. The decreased IP3 formation and its subsequent action, i.e., Ca2+ mobilization, may play an early but pivotal role by which sodium butyrate induces C6 glioma cell differentiation.},
	number = {3},
	urldate = {2012-01-04},
	journal = {Lipids},
	author = {Sun, S H and Ou, H C and Jang, T H and Lin, L B and Huang, H M},
	month = mar,
	year = {1997},
	pmid = {9076664},
	keywords = {Acylation, Animals, Arachidonic Acid, Butyric Acid, Butyric Acids, Calcium, Chloroform, Glioma, Glutamate-Ammonia Ligase, Glycerol, Histamine, Hydrolysis, Inositol, Inositol 1,4,5-Trisphosphate, Inositol Phosphates, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol Phosphates, Phosphatidylinositols, Phospholipids, Proteins, Rats, Thymidine, Tritium, Tumor Cells, Cultured},
	pages = {273--282},
}

Paper  abstract   bibtex   

@article{vartak_polyunsaturated_1997,
	title = {Polyunsaturated fatty acids increase the sensitivity of {36B10} rat astrocytoma cells to radiation-induced cell kill},
	volume = {32},
	issn = {0024-4201},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/9076665},
	abstract = {Polyunsaturated fatty acids (PUFA) such as gamma-linolenic acid (GLA, 18:3n-6), eicosapentaenoic acid (EPA, 20:5n-3), and docosahexaenoic acid (DHA, 22:6n-3) have been shown to be cytotoxic to tumor cells. The objective of this work was to study the effects of PUFA on the radiation response of a 36B10 rat astrocytoma cell line. Supplementation of the astrocytoma cells with 15-45 microM GLA, EPA, or DHA produced marked changes in the fatty acid profiles of their phospholipids and neutral lipids. The methylene bridge index of these lipids increased significantly. These PUFA also exerted cytotoxic effects, as determined using the clonogenic cell survival assay. While GLA and DHA produced a moderate cell-killing effect, EPA was extremely cytotoxic, especially at a concentration of 45 microM. The monounsaturated oleic acid (OA, 18:1n-9) did not affect cell survival. Further, all three PUFA, and particularly GLA, increased the radiation-induced cell kill; OA did not enhance the effect of radiation. alpha-Tocopherol acetate blocked the enhanced radiation sensitivity of GLA- and DHA-supplemented cells. In conclusion, GLA, EPA, and DHA supplementation prior to, during, and after irradiation can enhance the radiation-induced cytotoxicity of rat astrocytoma cells. GLA and DHA supplementation post-irradiation also enhanced the radiation response of the 36B10 cells. Because GLA maximally increases the radioresponsiveness of a rat astrocytoma, this PUFA might prove useful in increasing the therapeutic efficacy of radiation in the treatment of certain gliomas.},
	number = {3},
	urldate = {2012-01-03},
	journal = {Lipids},
	author = {Vartak, S and Robbins, M E and Spector, A A},
	month = mar,
	year = {1997},
	pmid = {9076665},
	keywords = {Animals, Astrocytoma, Cell Survival, Docosahexaenoic Acids, Dose-Response Relationship, Drug, Eicosapentaenoic Acid, Fatty Acids, Fatty Acids, Unsaturated, Lipid Metabolism, Oleic Acid, Phospholipids, Radiation-Sensitizing Agents, Rats, Time Factors, Tocopherols, Tumor Cells, Cultured, Vitamin E, alpha-Tocopherol, gamma-Linolenic Acid},
	pages = {283--292},
}

@Article{Kitzes1996,
  author   = {LM Kitzes and GS Hollrigel},
  journal  = {Hear Res},
  title    = {Response properties of units in the posterior auditory field deprived of input from the ipsilateral primary auditory cortex.},
  year     = {1996},
  note     = {as cited in \citeNP{Heil1998}},
  number   = {1-2},
  pages    = {120-30},
  volume   = {100},
  abstract = {The influence of the ipsilateral primary auditory field (AI) on the
	response properties of neurons in the posterior auditory field (Field
	P) was examined in three cats anesthetized with sodium pentobarbital.
	Rate/level functions were obtained, by extracellular recording, from
	single units in Field P before (n = 38) and after (n = 50) subpial
	aspiration of AI. The ablations were primarily confined to the medial
	ectosylvian gyrus, although in one case extended into the high-frequency
	portion of the anterior auditory field. Comparisons between the behavior
	of units isolated before and after AI ablation failed to demonstrate
	any changes in the response properties of neurons in Field P attributable
	to the ablation. Nonmonotonic response profiles, first spike latency,
	variability in latency, threshold and maximal discharge rates of
	the units to acoustic stimuli were not significantly altered by the
	AI ablation. These results indicate that the basic response properties
	of neurons in Field P do not depend on input from the ipsilateral
	AI. This suggests that these properties are most likely determined
	by thalamic input or by circuitry within Field P.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, 8922986},
}

@Article{Hermer1996,
  author   = {L. Hermer and E. Spelke},
  journal  = {Cognition},
  title    = {Modularity and development: the case of spatial reorientation.},
  year     = {1996},
  number   = {3},
  pages    = {195-232},
  volume   = {61},
  abstract = {In a series of experiments, young children who were disoriented in
	a novel environment reoriented themselves in accord with the large-scale
	shape of the environment but not in accord with nongeometric properties
	of the environment such as the color of a wall, the patterning on
	a box, or the categorical identity of an object. Because children's
	failure to reorient by nongeometric information cannot be attributed
	to limits on their ability to detect, remember, or use that information
	for other purposes, this failure suggests that children's reorientation,
	at least in relatively novel environments, depends on a mechanism
	that is informationally encapsulated and task-specific: two hallmarks
	of modular cognitive processes. Parallel studies with rats suggest
	that children share this mechanism with at least some adult nonhuman
	mammals. In contrast, our own studies of human adults, who readily
	solved our tasks by conjoining nongeometric and geometric information,
	indicated that the most striking limitations of this mechanism are
	overcome during human development. These findings support broader
	proposals concerning the domain specificity of humans' core cognitive
	abilities, the conservation of cognitive abilities across related
	species and over the course of human development, and the developmental
	processes by which core abilities are extended to permit more flexible,
	uniquely human kinds of problem solving.},
  keywords = {Adult, Animals, Attention, Child, Child Development, Color Perception, Female, Humans, Infant, Male, Mental Recall, Orientation, Preschool, Problem Solving, Rats, Social Environment, Species Specificity, 8990972},
}

@Article{Kanwisher1995,
  author   = {N Kanwisher and J Driver and L Machado},
  journal  = {Cognit Psychol},
  title    = {Spatial repetition blindness is modulated by selective attention to color or shape.},
  year     = {1995},
  number   = {3},
  pages    = {303-37},
  volume   = {29},
  abstract = {Subjects reported either the colors or shapes of two simultaneous
	masked letters. Our first study found that they were less accurate
	when the reported features were identical ("repetition blindness,"
	or RB), while repetition along the unreported dimension had no effect.
	Three follow-up studies confirmed that when the same dimension was
	judged (overtly or covertly) for both stimuli, performance was only
	affected by repetition along that dimension. However, when different
	dimensions were judged for the two stimuli, performance was affected
	by repetition on both dimensions. These findings support new conclusions
	about both RB and visual attention. First, RB depends critically
	on visual attention, rather than simply on the stimulus presented
	or the overt response required. Second, while attention can be restricted
	to a single visual dimension, this is efficient only when the same
	dimension is selected for both objects. Selecting the color of one
	object and the shape of another simultaneous object results in both
	dimensions being accessed for both objects.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, 8556848},
}

@article{yamamoto_ubiquitous_1992,
	title = {Ubiquitous presence in mammalian cells of enzymatic activity specifically cleaving 8-hydroxyguanine-containing {DNA}},
	volume = {83},
	issn = {0910-5050},
	doi = {10.1111/j.1349-7006.1992.tb00114.x},
	abstract = {Here we report the finding of enzymatic activity that specifically cleaves DNA containing 8-hydroxyguanine (oh8Gua) residues in various mammalian cells. To detect this activity, we used a synthetic double-stranded DNA containing a single oh8Gua at a defined position as the substrate, and analyzed the products of enzymatic digestion by polyacrylamide gel electrophoresis. Two cleavage sites near the oh8Gua residue were detected with partially purified fractions from cow brain and rat liver, and also with preparations from all mammalian tissues examined. These results suggest that enzymatic activity for the removal of oh8Gua from DNA is widely distributed in mammalian cells.},
	language = {eng},
	number = {4},
	journal = {Japanese Journal of Cancer Research: Gann},
	author = {Yamamoto, F. and Kasai, H. and Bessho, T. and Chung, M. H. and Inoue, H. and Ohtsuka, E. and Hori, T. and Nishimura, S.},
	month = apr,
	year = {1992},
	pmid = {1506269},
	pmcid = {PMC5918833},
	keywords = {Animals, Base Sequence, Brain, Cattle, DNA, DNA Repair, DNA-Formamidopyrimidine Glycosylase, Escherichia coli, Escherichia coli Proteins, Liver, Mammals, Molecular Sequence Data, N-Glycosyl Hydrolases, Oligodeoxyribonucleotides, Organ Specificity, Rats, Species Specificity, Substrate Specificity},
	pages = {351--357},
}

Website  bibtex   

@article{
 title = {DNA binding study of isophorone in rats and mice},
 type = {article},
 year = {1990},
 identifiers = {[object Object]},
 keywords = {Animals,Cyclohexanones/*metabolism,DNA/*metabolism,Female,Male,Mice,Rats,Rats, Inbred F344},
 pages = {684-685},
 volume = {64},
 websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2090039},
 edition = {1990/01/01},
 id = {be1a97a7-cc9c-3bef-a0c9-625b8898ee26},
 created = {2017-06-19T13:43:15.318Z},
 file_attached = {false},
 profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
 group_id = {b2078731-0913-33b9-8902-a53629a24e83},
 last_modified = {2017-06-19T13:43:15.427Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {Journal Article},
 language = {eng},
 notes = {<m:note>Thier, R<m:linebreak/>Peter, H<m:linebreak/>Wiegand, H J<m:linebreak/>Bolt, H M<m:linebreak/>Letter<m:linebreak/>Germany<m:linebreak/>Archives of toxicology<m:linebreak/>Arch Toxicol. 1990;64(8):684-5.</m:note>},
 bibtype = {article},
 author = {Thier, R and Peter, H and Wiegand, H J and Bolt, H M},
 journal = {Arch Toxicol},
 number = {8}
}

@Article{McLean1989,
  author   = {J McLean and LA Palmer},
  journal  = {Vision Res},
  title    = {Contribution of linear spatiotemporal receptive field structure to velocity selectivity of simple cells in area 17 of cat.},
  year     = {1989},
  number   = {6},
  pages    = {675-9},
  volume   = {29},
  abstract = {We have examined the spatiotemporal structure of simple receptive
	fields in the cat's striate cortex by cross-correlating their spike
	trains with an ensemble of stimuli consisting of stationary bright
	and dark spots whose position was randomized on each 50 msec frame.
	Receptive fields were found to be either separable or inseparable
	in space-time and responses to moving stimuli were predicted from
	the spatiotemporal structure of the cell under study. Most simple
	cells with separable spatiotemporal receptive fields were not direction
	selective. All simple cells with inseparable spatiotemporal receptive
	fields were found to prefer movement in one direction. The optimal
	speed and direction were estimable from the slope of individual subregions
	observed in the space-time plane. The results are consistent with
	a linear model for direction selectivity.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, 2626824},
}

@Article{Morris1986,
  author   = {RG Morris and E Anderson and GS Lynch and M Baudry},
  journal  = {Nature},
  title    = {Selective impairment of learning and blockade of long-term potentiation by an {N}-methyl-{D}-aspartate receptor antagonist, {AP}5.},
  year     = {1986},
  number   = {6056},
  pages    = {774-6},
  volume   = {319},
  abstract = {Recent work has shown that the hippocampus contains a class of receptors
	for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate
	(NMDA) and that exhibit a peculiar dependency on membrane voltage
	in becoming active only on depolarization. Blockade of these sites
	with the drug aminophosphonovaleric acid (AP5) does not detectably
	affect synaptic transmission in the hippocampus, but prevents the
	induction of hippocampal long-term potentiation (LTP) following brief
	high-frequency stimulation. We now report that chronic intraventricular
	infusion of D,L-AP5 causes a selective impairment of place learning,
	which is highly sensitive to hippocampal damage, without affecting
	visual discrimination learning, which is not. The L-isomer of AP5
	did not produce behavioural effects. AP5 treatment also suppressed
	LTP in vivo. These results suggest that NMDA receptors are involved
	in spatial learning, and add support to the hypothesis that LTP is
	involved in some, but not all, forms of learning.},
  keywords = {Amygdala, Animals, Evaluation Studies, Hippocampus, Human, Learning, Long-Term Potentiation, Memory, Models, Neurological, Neural Pathways, Neuronal Plasticity, Support, Non-U.S. Gov't, Synapses, 2-Amino-5-phosphonovalerate, Electric Stimulation, Isomerism, Rats, Receptors, N-Methyl-D-Aspartate, Neurotransmitter, Valine, Visual Perception, 2869411},
}

@Article{Phillips1985,
  author   = {DP Phillips and JR Mendelson and MS Cynader and RM Douglas},
  journal  = {Exp Brain Res},
  title    = {Responses of single neurones in cat auditory cortex to time-varying stimuli: {F}requency-modulated tones of narrow excursion.},
  year     = {1985},
  number   = {3},
  pages    = {443-54},
  volume   = {58},
  abstract = {In the primary auditory cortex of cats anaesthetized with nitrous
	oxide, single neurones were examined with respect to their responses
	to tone bursts and linear modulations of the frequency of an on-going
	continuous tone. Using FM ramps of 2.0 kHz excursion and varying
	centre frequency, each of 39 neurones was examined for its preference
	for the direction of frequency change of a ramp whose centre frequency
	was varied in and around the neurone's response area. Direction preference
	was strictly associated with the slopes of the cell's spike count-versus-frequency
	function over the frequency range covered by the ramp. Preferences
	for upward- and downward-directed ramps were associated with the
	low- and high-frequency slopes of the spike count function, respectively.
	The strength of the cell's direction preference was associated with
	the relative steepness of the spike count function over the frequency
	range covered by the ramp. The timing of discharges elicited by the
	frequency modulations was found to be the sum of the cell's latent
	period for tone bursts plus the time after ramp onset that the stimulus
	frequency fell within the neurone's response area. The implications
	of these data for the processing of narrow and broad frequency-modulated
	ramps are discussed.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, Neural Conduction, 4007088},
}

@Article{Phillips1984,
  author   = {DP Phillips and SS Orman},
  journal  = {J Neurophysiol},
  title    = {Responses of single neurons in posterior field of cat auditory cortex to tonal stimulation.},
  year     = {1984},
  note     = {as cited by \citeNP{Heil1998}},
  number   = {1},
  pages    = {147-63},
  volume   = {51},
  abstract = {In the auditory cortex of barbiturate-anesthetized cats, the posterior
	auditory field (field P) was identified by its tonotopic organization,
	and single neurons in that field were studied quantitatively for
	their sensitivity to the frequency and intensity of tonal stimuli
	presented via calibrated, sealed stimulating systems. Field P neurons
	had narrow, V-shaped, threshold frequency tuning curves. At suprathreshold
	levels, spike counts were generally greatest at frequencies at or
	close to the neuron's threshold best frequency (BF). Eighty-six percent
	of posterior-field neurons displayed spike counts that were a nonmonotonic
	function of the intensity of a BF tone. Of these, over 90\% showed
	at least a 50\% reduction in spike count at high stimulus levels,
	and almost 20\% of nonmonotonic cells ceased responding entirely
	at high stimulus intensities. The nonmonotonic shape of spike count-versus-intensity
	profiles was typically preserved across the range of frequencies
	to which any given neuron was responsive. For some neurons, this
	had the consequence of generating a completely circumscribed frequency-intensity
	response area. That is, these neurons responded to a tonal stimulus
	only if the stimulus was within a restricted range of both frequency
	and intensity. These response areas showed internal organizations
	that appeared to reflect one or both of two processes. For some neurons,
	the optimal sound pressure level for spike counts varied with tone
	frequency, roughly paralleling the threshold tuning curve. For other
	neurons, the optimal sound pressure level tended to be constant across
	frequency despite threshold variations of up to 20 dB. The minimum
	response latencies of posterior-field neurons were generally in the
	range of 20-50 ms, while cells in the primary auditory cortex (AI)
	in the same animals generally had minimum latent periods of less
	than 20 ms. Comparison of these data with those previously presented
	for neurons in two other cortical auditory fields suggests that the
	cat's auditory cortex might show an interfield segregation of neurons
	according to their coding properties.},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, Intelligence, Macaca fascicularis, Adoption, Critical Period (Psychology), France, Korea, Magnetic Resonance Imaging, Multilingualism, Auditory Pathways, Cochlear Nerve, Loudness Perception, 6693932},
}

@article{anbalagan_influence_1981,
	title = {Influence of an {Indian} medicine ({Ashwagandha}) on acute-phase reactants in inflammation},
	volume = {19},
	issn = {0019-5189},
	language = {eng},
	number = {3},
	journal = {Indian Journal of Experimental Biology},
	author = {Anbalagan, K. and Sadique, J.},
	month = mar,
	year = {1981},
	pmid = {7251069},
	keywords = {Acute Disease, Animals, Anti-Inflammatory Agents, Arthritis, Arthritis, Experimental, Plant Extracts, Plants, Medicinal, Rats, Withania},
	pages = {245--249},
}

@article{mathur_influence_1979,
	title = {Influence of zinc on onset and progression of oral carcinogenesis in rats},
	volume = {37},
	issn = {0001-6357},
	doi = {10.3109/00016357909004697},
	abstract = {Three-week-old female rats were fed 0.09 (zinc-deficient), 0.77 (zinc-adequate) or 3.98 (zinc-supplemented) mmol zinc/kg diet in three experimental groups and the palatal mucosa was painted with the water-soluble carcinogen 4-nitroquinoline N-oxide (4NQO) three times a week for 20 weeks. The zinc-supplemented diet seemed to retard the induction of carcinogenesis, whereas a low-zinc diet had the opposite effect. Once initial cellular changes had been induced the supplementary zinc seemed to accelerate their further advancement. Zinc-deficiency in animals fed a copper/zinc low-zinc diet was reflected in the plasma and liver zinc levels as well as in the copper/zinc ratio. The development of cancer was accompanied by a decrease in plasma zinc and an increase in the plasma copper/zinc ratio as well as in the liver zinc. These changes were most remarkable in the zinc-supplemented group.},
	language = {eng},
	number = {5},
	journal = {Acta Odontologica Scandinavica},
	author = {Mathur, A. and Wallenius, K. and Abdulla, M.},
	year = {1979},
	pmid = {118633},
	keywords = {4-Nitroquinoline-1-oxide, Animals, Copper, Female, Male, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Experimental, Palate, Soft, Rats, Zinc},
	pages = {277--284},
}

@Article{MMN-Original,
  author   = {N\"{a}\"{a}t\"{a}nen, R and Gaillard, AW and M\"{a}ntysalo, S},
  journal  = {Acta Psychol (Amst)},
  title    = {Early selective-attention effect on evoked potential reinterpreted.},
  year     = {1978},
  number   = {4},
  pages    = {313-29},
  volume   = {42},
  keywords = {Computing Methodologies, Human, Language, Learning, Mental Processes, Models, Theoretical, Stochastic Processes, Support, U.S. Gov't, Non-P.H.S., Cognition, Linguistics, Neural Networks (Computer), Practice (Psychology), Non-U.S. Gov't, Memory, Psychological, Task Performance and Analysis, Time Factors, Visual Perception, Adult, Attention, Discrimination Learning, Female, Male, Short-Term, Mental Recall, Orientation, Pattern Recognition, Visual, Perceptual Masking, Reading, Concept Formation, Form Perception, Animals, Corpus Striatum, Shrews, P.H.S., Visual Cortex, Visual Pathways, Acoustic Stimulation, Auditory Cortex, Auditory Perception, Cochlea, Ear, Gerbillinae, Glycine, Hearing, Neurons, Space Perception, Strychnine, Adolescent, Decision Making, Reaction Time, Astrocytoma, Brain Mapping, Brain Neoplasms, Cerebral Cortex, Electric Stimulation, Electrophysiology, Epilepsy, Temporal Lobe, Evoked Potentials, Frontal Lobe, Noise, Parietal Lobe, Scalp, Child, Language Development, Psycholinguistics, Brain, Perception, Speech, Vocalization, Animal, Discrimination (Psychology), Hippocampus, Rats, Calcium, Chelating Agents, Excitatory Postsynaptic Potentials, Glutamic Acid, Guanosine Diphosphate, In Vitro, Neuronal Plasticity, Pyramidal Cells, Receptors, AMPA, Metabotropic Glutamate, N-Methyl-D-Aspartate, Somatosensory Cortex, Synapses, Synaptic Transmission, Thionucleotides, Action Potentials, Calcium Channels, L-Type, Electric Conductivity, Entorhinal Cortex, Neurological, Long-Evans, Infant, Mathematics, Statistics, Probability Learning, Problem Solving, Psychophysics, Association Learning, Child Psychology, Habituation (Psychophysiology), Probability Theory, Analysis of Variance, Semantics, Symbolism, Behavior, Eye Movements, Macaca mulatta, Prefrontal Cortex, Cats, Dogs, Haplorhini, Photic Stimulation, Electroencephalography, Nervous System Physiology, Darkness, Grasshoppers, Light, Membrane Potentials, Neural Inhibition, Afferent, Picrotoxin, Vision, Deoxyglucose, Injections, Microspheres, Neural Pathways, Rhodamines, Choice Behavior, Speech Perception, Verbal Learning, Dominance, Cerebral, Fixation, Ocular, Language Tests, Random Allocation, Comparative Study, Saguinus, Sound Spectrography, Species Specificity, Audiometry, Auditory Threshold, Calibration, Data Interpretation, Statistical, Anesthesia, General, Electrodes, Implanted, Pitch Perception, Sound Localization, Paired-Associate Learning, Serial Learning, Auditory, Age Factors, Motion Perception, Brain Injuries, Computer Simulation, Blindness, Psychomotor Performance, Color Perception, Signal Detection (Psychology), Judgment, ROC Curve, Regression Analysis, Music, Probability, Arm, Cerebrovascular Disorders, Hemiplegia, Movement, Muscle, Skeletal, Myoclonus, Robotics, Magnetoencephalography, Phonetics, Software, Speech Production Measurement, Epilepsies, Partial, Laterality, Stereotaxic Techniques, Germany, Speech Acoustics, Verbal Behavior, Child Development, Instinct, Brain Stem, Coma, Diagnosis, Differential, Hearing Disorders, Hearing Loss, Central, Neuroma, Acoustic, Dendrites, Down-Regulation, Patch-Clamp Techniques, Wistar, Up-Regulation, Aged, Aphasia, Middle Aged, Cones (Retina), Primates, Retina, Retinal Ganglion Cells, Tympanic Membrane, Cell Communication, Extremities, Biological, Motor Activity, Rana catesbeiana, Spinal Cord, Central Nervous System, Motion, Motor Cortex, 685709},
}

@article{halaris_antidepressant_1975,
	title = {Antidepressant drugs affect dopamine uptake},
	volume = {24},
	issn = {0006-2952},
	language = {eng},
	number = {20},
	journal = {Biochemical pharmacology},
	author = {Halaris, A E and Belendiuk, K T and Freedman, D X},
	month = oct,
	year = {1975},
	note = {00096 PMID: 19},
	keywords = {Animals, Antidepressive Agents, Brain, Central Nervous System Stimulants, Depression, Chemical, Dopamine, Male, Rats},
	pages = {1896--1897}
}

@article{gmaj_effects_1975,
	title = {Effects of maleate on renal reabsorption of bicarbonate},
	volume = {4},
	issn = {0300-1725},
	language = {ENG},
	journal = {Current Problems in Clinical Biochemistry},
	author = {Gmaj, P. and Hoppe, A. and Angielski, S. and Rogulski, J. and Metler, M.},
	year = {1975},
	pmid = {211},
	keywords = {Acetazolamide, Adenosine Triphosphate, Animals, Arsenic, Bicarbonates, Chlorides, Glomerular Filtration Rate, Hydrogen-Ion Concentration, Ketoglutaric Acids, Kidney, Maleates, Potassium, Rats, Sodium},
	pages = {101--105}
}

@article{akamatsu_increase_1975,
	title = {Increase in acetyl {CoA} synthetase activity after phenobarbital treatment},
	volume = {24},
	issn = {0006-2952},
	doi = {10.1016/0006-2952(75)90013-1},
	language = {eng},
	number = {18},
	journal = {Biochemical Pharmacology},
	author = {Akamatsu, N. and Nakajima, H. and Ono, M. and Miura, Y.},
	month = sep,
	year = {1975},
	pmid = {15},
	keywords = {Acetate-CoA Ligase, Acetylesterase, Acetylglucosamine, Animals, Coenzyme A Ligases, Cycloheximide, Glucosamine, Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing), Liver, Male, Phenobarbital, Phosphotransferases, Proteins, Rats, Stimulation, Chemical},
	pages = {1725--1727},
}

Paper  doi  abstract   bibtex   

@article{driscoll_acute_nodate,
	title = {Acute postnatal exposure to the {pentaBDE} commercial mixture {DE}-71 at 5 or 15 mg/kg/day does not produce learning or attention deficits in rats.},
	volume = {34},
	issn = {1872-9738},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22024237},
	doi = {10.1016/j.ntt.2011.10.002},
	abstract = {Polybrominated diphenyl ethers (PBDEs), flame retardant chemicals added to polymer products, have become ubiquitous in the environment, and they are bioaccumulating in humans and wildlife. Therefore, understanding their biological effects is important for public health. We have previously observed learning deficits in rats exposed to DE-71, a commercial PBDE mixture consisting primarily of pentabrominated diphenyl ethers, at a dose of 30 mg/kg/day from postnatal day (PND) 6 to 12. The purpose of the current study was to determine if this effect could be seen with lower doses of DE-71. Long-Evans rats were administered daily oral doses of corn oil alone or DE-71, 5 or 15 mg/kg/day, dissolved in corn oil, from PND 6 to 12. As young adults, the rats were administered a series of five-choice visual learning and attention tasks. No effects of DE-71 were found on learning, attention, or inhibitory control. Given that developmental DE-71 exposure at similar doses and for shorter time periods has been shown in other laboratories to affect locomotion and hyperactivity, the current results suggest that cognitive functions may not be as sensitive as neuromotor functions to the effects of acute DE-71 exposure.},
	number = {1},
	journal = {Neurotoxicology and teratology},
	author = {Driscoll, Lori L and Kaplan, Joshua and Bucuvalas, Eleni and Allen, Hunter and Kraut, Joshua and Fitzpatrick, Jesse},
	pmid = {22024237},
	keywords = {Acute Disease, Animal, Animals, Attention Deficit Disorder with Hyperactivity, Attention Deficit Disorder with Hyperactivity: che, Attention Deficit Disorder with Hyperactivity: dia, Attention Deficit Disorder with Hyperactivity: phy, Cognition Disorders, Cognition Disorders: chemically induced, Cognition Disorders: diagnosis, Cognition Disorders: physiopathology, Disease Models, Environmental Exposure, Environmental Exposure: adverse effects, Female, Flame Retardants: toxicity, Flame retardants, Halogenated Diphenyl Ethers, Halogenated Diphenyl Ethers: toxicity, Learning Disorders, Learning Disorders: chemically induced, Learning Disorders: diagnosis, Learning Disorders: physiopathology, Long-Evans, Male, Newborn, Rats},
	pages = {20--6},
}